Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	Fc receptor signaling pathway	BTK RAPGEF1 PLCG1 KIT VAV1	7.94e-06	62	91	5	GO:0038093
GeneOntologyBiologicalProcess	neural tube closure	CELSR1 CECR2 PRKACA PRKACB KDM2B ZEB2	1.08e-05	113	91	6	GO:0001843
GeneOntologyBiologicalProcess	tube closure	CELSR1 CECR2 PRKACA PRKACB KDM2B ZEB2	1.14e-05	114	91	6	GO:0060606
GeneOntologyBiologicalProcess	primary neural tube formation	CELSR1 CECR2 PRKACA PRKACB KDM2B ZEB2	1.52e-05	120	91	6	GO:0014020
GeneOntologyBiologicalProcess	neural tube formation	CELSR1 CECR2 PRKACA PRKACB KDM2B ZEB2	2.85e-05	134	91	6	GO:0001841
GeneOntologyBiologicalProcess	neural tube development	CELSR1 ATP6AP2 CECR2 PRKACA PRKACB KDM2B ZEB2	3.14e-05	202	91	7	GO:0021915
GeneOntologyBiologicalProcess	chordate embryonic development	CELSR1 ZBED6 ATP6AP2 EIF4A3 CECR2 PRKACA PRKACB KDM2B POLR1B PLCG1 THOC2 MMP16 ZEB2 USP17L15	4.12e-05	906	91	14	GO:0043009
GeneOntologyBiologicalProcess	embryo development	CELSR1 ZBED6 ATP6AP2 EIF4A3 ATP8A2 CECR2 MYO3B PRKACA PRKACB KDM2B LRP5 POLR1B PLCG1 THOC2 MMP16 KIT ZEB2 USP17L15	4.81e-05	1437	91	18	GO:0009790
GeneOntologyBiologicalProcess	embryo development ending in birth or egg hatching	CELSR1 ZBED6 ATP6AP2 EIF4A3 CECR2 PRKACA PRKACB KDM2B POLR1B PLCG1 THOC2 MMP16 ZEB2 USP17L15	5.40e-05	929	91	14	GO:0009792
GeneOntologyBiologicalProcess	melanocyte migration	KIT ZEB2	5.76e-05	3	91	2	GO:0097324
GeneOntologyBiologicalProcess	embryonic epithelial tube formation	CELSR1 CECR2 PRKACA PRKACB KDM2B ZEB2	7.41e-05	159	91	6	GO:0001838
GeneOntologyBiologicalProcess	epithelial tube formation	CELSR1 CECR2 PRKACA PRKACB KDM2B ZEB2	1.18e-04	173	91	6	GO:0072175
GeneOntologyBiologicalProcess	Fc-epsilon receptor signaling pathway	BTK PLCG1 VAV1	1.78e-04	25	91	3	GO:0038095
GeneOntologyBiologicalProcess	tube formation	CELSR1 CECR2 PRKACA PRKACB KDM2B ZEB2	1.80e-04	187	91	6	GO:0035148
GeneOntologyBiologicalProcess	morphogenesis of embryonic epithelium	CELSR1 CECR2 PRKACA PRKACB KDM2B ZEB2	1.97e-04	190	91	6	GO:0016331
GeneOntologyBiologicalProcess	cilium disassembly	HDAC6 KIF19	2.85e-04	6	91	2	GO:0061523
GeneOntologyBiologicalProcess	embryonic morphogenesis	CELSR1 EIF4A3 ATP8A2 CECR2 MYO3B PRKACA PRKACB KDM2B LRP5 MMP16 ZEB2	2.99e-04	713	91	11	GO:0048598
GeneOntologyCellularComponent	perinuclear region of cytoplasm	NPC1 HDAC6 KCND3 EIF4A2 BTK PRKACA PRKACB ABCC5 RAPGEF1 SPIRE1 EML1 CDC5L RYR3 FBXL5	4.37e-05	934	90	14	GO:0048471
HumanPheno	Abnormality of the calf	GABRD TRAPPC11 IARS2 ANAPC1 EIF4A3 CYP19A1 PRKACA PRKACB POMGNT1 LRP5 NEB MMP13 ZEB2	3.82e-06	384	40	13	HP:0002981
HumanPheno	Iris atrophy	VWA8 LRP5 ZEB2	2.45e-05	8	40	3	HP:0001089
MousePheno	abnormal learning/memory/conditioning	NPC1 GABRD ZC3H14 HDAC6 KCNT2 NRDC KCND3 SRGAP3 CECR2 CYP19A1 EIF4A2 PRKACB SPIRE1 EML1 LHX8 THOC2 TOX2 RYR3	4.07e-05	1239	72	18	MP:0002063
MousePheno	abnormal cognition	NPC1 GABRD ZC3H14 HDAC6 KCNT2 NRDC KCND3 SRGAP3 CECR2 CYP19A1 EIF4A2 PRKACB SPIRE1 EML1 LHX8 THOC2 TOX2 RYR3	4.38e-05	1246	72	18	MP:0014114
Domain	SH3_1	ARHGAP4 SRGAP3 SRGAP1 BTK PACSIN3 SRGAP2 PLCG1 NEB UBASH3A VAV1	4.13e-09	164	86	10	PF00018
Domain	SH3	DOCK2 ARHGAP4 SRGAP3 SRGAP1 BTK PACSIN3 SRGAP2 PLCG1 NEB UBASH3A VAV1	4.39e-09	216	86	11	SM00326
Domain	SH3	DOCK2 ARHGAP4 SRGAP3 SRGAP1 BTK PACSIN3 SRGAP2 PLCG1 NEB UBASH3A VAV1	4.39e-09	216	86	11	PS50002
Domain	SH3_domain	DOCK2 ARHGAP4 SRGAP3 SRGAP1 BTK PACSIN3 SRGAP2 PLCG1 NEB UBASH3A VAV1	5.32e-09	220	86	11	IPR001452
Domain	FCH	ARHGAP4 SRGAP3 SRGAP1 PACSIN3 SRGAP2	4.56e-08	22	86	5	PF00611
Domain	FCH	ARHGAP4 SRGAP3 SRGAP1 PACSIN3 SRGAP2	4.56e-08	22	86	5	SM00055
Domain	FCH_dom	ARHGAP4 SRGAP3 SRGAP1 PACSIN3 SRGAP2	5.80e-08	23	86	5	IPR001060
Domain	F_BAR	ARHGAP4 SRGAP3 SRGAP1 PACSIN3 SRGAP2	9.09e-08	25	86	5	IPR031160
Domain	F_BAR	ARHGAP4 SRGAP3 SRGAP1 PACSIN3 SRGAP2	9.09e-08	25	86	5	PS51741
Domain	SH2	BTK SHB SHE PLCG1 VAV1	1.03e-04	101	86	5	PF00017
Domain	SH2	BTK SHB SHE PLCG1 VAV1	1.54e-04	110	86	5	SM00252
Domain	SH2	BTK SHB SHE PLCG1 VAV1	1.61e-04	111	86	5	PS50001
Domain	SH2	BTK SHB SHE PLCG1 VAV1	1.68e-04	112	86	5	IPR000980
Domain	-	BTK SHB SHE PLCG1 VAV1	1.68e-04	112	86	5	3.30.505.10
Domain	RhoGAP	ARHGAP4 SRGAP3 SRGAP1 SRGAP2	1.91e-04	62	86	4	SM00324
Domain	RhoGAP	ARHGAP4 SRGAP3 SRGAP1 SRGAP2	2.03e-04	63	86	4	PF00620
Domain	RhoGAP_dom	ARHGAP4 SRGAP3 SRGAP1 SRGAP2	2.16e-04	64	86	4	IPR000198
Domain	RHOGAP	ARHGAP4 SRGAP3 SRGAP1 SRGAP2	2.16e-04	64	86	4	PS50238
Domain	-	ARHGAP4 SRGAP3 SRGAP1 SRGAP2	2.16e-04	64	86	4	1.10.555.10
Domain	Rho_GTPase_activation_prot	ARHGAP4 SRGAP3 SRGAP1 SRGAP2	7.28e-04	88	86	4	IPR008936
Domain	VWF_A	CPNE2 VWA8 ANAPC1 ITIH2	1.13e-03	99	86	4	IPR002035
Domain	ATPase_dyneun-rel_AAA	VWA8 DNAH9	1.84e-03	14	86	2	IPR011704
Domain	AAA_5	VWA8 DNAH9	1.84e-03	14	86	2	PF07728
Domain	Pept_M10A_Zn_BS	MMP13 MMP16	2.12e-03	15	86	2	IPR021158
Domain	AGC-kinase_C	RPS6KA4 PRKACA PRKACB	2.19e-03	56	86	3	IPR000961
Domain	AGC_KINASE_CTER	RPS6KA4 PRKACA PRKACB	2.19e-03	56	86	3	PS51285
Domain	S_TK_X	RPS6KA4 PRKACA PRKACB	2.19e-03	56	86	3	SM00133
Domain	Hemopexin_CS	MMP13 MMP16	2.72e-03	17	86	2	IPR018486
Domain	Pept_M10A_stromelysin-type	MMP13 MMP16	3.06e-03	18	86	2	IPR016293
Domain	CH	CLMN ACTN1 VAV1	3.35e-03	65	86	3	SM00033
Domain	Leu-rich_rpt_Cys-con_subtyp	KDM2B FBXL5	3.41e-03	19	86	2	IPR006553
Domain	LRR_CC	KDM2B FBXL5	3.41e-03	19	86	2	SM00367
Domain	PG_binding_1	MMP13 MMP16	3.77e-03	20	86	2	PF01471
Domain	Peptidoglycan-bd-like	MMP13 MMP16	3.77e-03	20	86	2	IPR002477
Domain	CH	CLMN ACTN1 VAV1	4.13e-03	70	86	3	PF00307
Domain	EF_HAND_2	SDF4 PLCG1 ACTN1 TBC1D9 RYR3	4.28e-03	231	86	5	PS50222
Domain	-	CLMN ACTN1 VAV1	4.30e-03	71	86	3	1.10.418.10
Domain	EF_hand_dom	SDF4 PLCG1 ACTN1 TBC1D9 RYR3	4.36e-03	232	86	5	IPR002048
Pathway	REACTOME_INACTIVATION_OF_CDC42_AND_RAC1	SRGAP3 SRGAP1 SRGAP2	6.73e-06	8	71	3	M27349
Pathway	REACTOME_FCERI_MEDIATED_CA_2_MOBILIZATION	IGHV2-70 IGHV2-5 BTK PLCG1 VAV1	7.13e-05	86	71	5	M27206
Pathway	REACTOME_SIGNALING_BY_ROBO_RECEPTORS	PSMD6 SRGAP3 EIF4A3 SRGAP1 PRKACA PRKACB SRGAP2	1.10e-04	218	71	7	M2780
Pathway	REACTOME_LEISHMANIA_INFECTION	IGHV2-70 IGHV2-5 BTK PRKACA PRKACB PLCG1 VAV1	1.14e-04	219	71	7	M29836
Pathway	REACTOME_FCGR3A_MEDIATED_IL10_SYNTHESIS	IGHV2-70 IGHV2-5 PRKACA PRKACB PLCG1	1.15e-04	95	71	5	M29842
Pathway	REACTOME_SIGNALING_BY_VEGF	SHB PRKACA PRKACB PLCG1 VAV1	1.68e-04	103	71	5	MM14752
Pathway	PID_PDGFRA_PATHWAY	SHB RAPGEF1 PLCG1	1.76e-04	22	71	3	M206
Pathway	REACTOME_SIGNALING_BY_VEGF	SHB PRKACA PRKACB PLCG1 VAV1	1.92e-04	106	71	5	M27077
Pathway	WP_KIT_RECEPTOR_SIGNALING	BTK PLCG1 KIT VAV1	2.18e-04	59	71	4	M39350
Pathway	REACTOME_RAC1_GTPASE_CYCLE	DOCK2 ARHGAP4 SRGAP3 SRGAP1 SRGAP2 VAV1	2.47e-04	175	71	6	MM15599
Pathway	REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_KEY_METABOLIC_FACTORS	PRKACA PRKACB	2.48e-04	5	71	2	M26988
Pathway	REACTOME_SIGNALING_BY_ERYTHROPOIETIN	RAPGEF1 PLCG1 VAV1	2.60e-04	25	71	3	M27865
Pathway	REACTOME_RAC1_GTPASE_CYCLE	DOCK2 ARHGAP4 SRGAP3 SRGAP1 SRGAP2 VAV1	3.23e-04	184	71	6	M41809
Pathway	REACTOME_FC_EPSILON_RECEPTOR_FCERI_SIGNALING	PSMD6 IGHV2-70 IGHV2-5 BTK PLCG1 VAV1	3.42e-04	186	71	6	M27175
Pathway	REACTOME_GLUCAGON_SIGNALING_IN_METABOLIC_REGULATION	PRKACA PRKACB	3.70e-04	6	71	2	MM14628
Pathway	PID_VEGFR1_2_PATHWAY	MYOF SHB PRKACA PLCG1	3.99e-04	69	71	4	M237
Pathway	REACTOME_ISG15_ANTIVIRAL_MECHANISM	EIF4A3 EIF4A2 PLCG1	4.07e-04	29	71	3	MM17065
Pathway	WP_KIT_RECEPTOR_SIGNALING_PATHWAY	BTK PLCG1 KIT VAV1	4.45e-04	71	71	4	MM15947
Pathway	KEGG_MEDICUS_REFERENCE_PKA_HOLOENZYME	PRKACA PRKACB	5.17e-04	7	71	2	M47896
Pathway	REACTOME_HDL_ASSEMBLY	PRKACA PRKACB	5.17e-04	7	71	2	MM15560
Pathway	BIOCARTA_BCR_PATHWAY	BTK PLCG1 VAV1	5.47e-04	32	71	3	MM1355
Pathway	REACTOME_ANTI_INFLAMMATORY_RESPONSE_FAVOURING_LEISHMANIA_PARASITE_INFECTION	IGHV2-70 IGHV2-5 PRKACA PRKACB PLCG1	5.67e-04	134	71	5	M29840
Pathway	PID_EPO_PATHWAY	BTK RAPGEF1 PLCG1	5.99e-04	33	71	3	M233
Pathway	BIOCARTA_BCR_PATHWAY	BTK PLCG1 VAV1	5.99e-04	33	71	3	M9494
Pathway	REACTOME_HDL_ASSEMBLY	PRKACA PRKACB	6.87e-04	8	71	2	M27840
Pathway	REACTOME_FCGAMMA_RECEPTOR_FCGR_DEPENDENT_PHAGOCYTOSIS	IGHV2-70 IGHV2-5 BTK PLCG1 VAV1	7.62e-04	143	71	5	M27107
Pathway	BIOCARTA_PLC_PATHWAY	PLCG1 VAV1	8.80e-04	9	71	2	M22029
Pathway	BIOCARTA_PLC_PATHWAY	PLCG1 VAV1	8.80e-04	9	71	2	MM1551
Pathway	REACTOME_ROBO_RECEPTORS_BIND_AKAP5	PRKACA PRKACB	8.80e-04	9	71	2	M27877
Pathway	REACTOME_RET_SIGNALING	PRKACA PRKACB PLCG1	9.10e-04	38	71	3	MM15493
Pathway	REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_BCR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS	IGHV2-70 IGHV2-5 BTK VAV1	9.19e-04	86	71	4	M601
Pathway	REACTOME_FCERI_MEDIATED_MAPK_ACTIVATION	IGHV2-70 IGHV2-5 PLCG1 VAV1	9.60e-04	87	71	4	M27205
Pathway	BIOCARTA_FCER1_PATHWAY	BTK PLCG1 VAV1	9.82e-04	39	71	3	MM1397
Pathway	BIOCARTA_FCER1_PATHWAY	BTK PLCG1 VAV1	9.82e-04	39	71	3	M1908
Pathway	REACTOME_RET_SIGNALING	PRKACA PRKACB PLCG1	1.06e-03	40	71	3	M27746
Pathway	KEGG_MEDICUS_REFERENCE_AVP_V2R_PKA_SIGNALING_PATHWAY	PRKACA PRKACB	1.10e-03	10	71	2	M47648
Pathway	REACTOME_ERYTHROPOIETIN_ACTIVATES_RAS	RAPGEF1 VAV1	1.10e-03	10	71	2	MM15624
Pathway	REACTOME_INTERLEUKIN_3_INTERLEUKIN_5_AND_GM_CSF_SIGNALING	PRKACA RAPGEF1 VAV1	1.14e-03	41	71	3	MM15162
Pathway	REACTOME_DAG_AND_IP3_SIGNALING	PRKACA PRKACB PLCG1	1.14e-03	41	71	3	M512
Pathway	REACTOME_CDC42_GTPASE_CYCLE	ARHGAP4 SRGAP3 SRGAP1 SRGAP2	1.28e-03	94	71	4	MM15598
Pathway	WP_B_CELL_RECEPTOR_SIGNALING	BTK RAPGEF1 PLCG1 VAV1	1.44e-03	97	71	4	M39323
Pathway	REACTOME_SIGNALING_BY_THE_B_CELL_RECEPTOR_BCR	PSMD6 IGHV2-70 IGHV2-5 BTK VAV1	1.48e-03	166	71	5	M608
Pathway	REACTOME_RHO_GTPASE_CYCLE	DOCK2 ARHGAP4 SRGAP3 SRGAP1 RAPGEF1 SRGAP2 ACTN1 VAV1	1.58e-03	439	71	8	MM15595
Pathway	WP_TRANSLATION_INHIBITORS_IN_CHRONICALLY_ACTIVATED_PDGFRA_CELLS	RPS6KA4 EIF4A2 PRKACA	1.59e-03	46	71	3	M39805
Pathway	PID_RHOA_REG_PATHWAY	ARHGAP4 SRGAP1 VAV1	1.59e-03	46	71	3	M68
Pathway	REACTOME_REGULATION_OF_GLYCOLYSIS_BY_FRUCTOSE_2_6_BISPHOSPHATE_METABOLISM	PRKACA PRKACB	1.60e-03	12	71	2	M27950
Pathway	REACTOME_Z_DECAY_DEGRADATION_OF_MATERNAL_MRNAS_BY_ZYGOTICALLY_EXPRESSED_FACTORS	EIF4A3 EIF4A2	1.60e-03	12	71	2	M48027
Pathway	REACTOME_CREB1_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_ADENYLATE_CYCLASE	PRKACA PRKACB	1.60e-03	12	71	2	M27363
Pathway	REACTOME_INTERLEUKIN_3_INTERLEUKIN_5_AND_GM_CSF_SIGNALING	PRKACA RAPGEF1 VAV1	1.80e-03	48	71	3	M914
Pathway	REACTOME_RHO_GTPASE_CYCLE	DOCK2 ARHGAP4 SRGAP3 SRGAP1 RAPGEF1 SRGAP2 ACTN1 VAV1	1.85e-03	450	71	8	M27078
Pathway	WP_MFAP5MEDIATED_OVARIAN_CANCER_CELL_MOTILITY_AND_INVASIVENESS	PLCG1 RYR3	1.88e-03	13	71	2	M39463
Pathway	WP_DOPAMINE_METABOLISM	PRKACA PRKACB	1.88e-03	13	71	2	M39622
Pathway	WP_IL3_SIGNALING	PRKACA RAPGEF1 VAV1	1.91e-03	49	71	3	M39722
Pubmed	FNBP2 gene on human chromosome 1q32.1 encodes ARHGAP family protein with FCH, FBH, RhoGAP and SH3 domains.	ARHGAP4 SRGAP3 SRGAP1 SRGAP2	6.85e-10	6	92	4	12736724
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	MED20 ZC3H14 MYOF GUF1 LARP4B CELSR1 CAD ANAPC1 ZBED6 ATP6AP2 PRKACA PACSIN3 KDM2B SPIRE1 POLR1B SRGAP2 ACTN1 LAS1L IK	1.13e-08	1497	92	19	31527615
Pubmed	Dynamic expression of the Slit-Robo GTPase activating protein genes during development of the murine nervous system.	SRGAP3 SRGAP1 SRGAP2	1.79e-08	3	92	3	19137586
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	CPNE2 ZC3H14 MYOF LARP4B IARS2 CAD RPS6KA4 EIF4A3 SRGAP1 PACSIN3 POLR1B ACTN1 CDC5L LAS1L IK THOC2 ITIH2	3.00e-08	1257	92	17	36526897
Pubmed	Enhanced prediction of Src homology 2 (SH2) domain binding potentials using a fluorescence polarization-derived c-Met, c-Kit, ErbB, and androgen receptor interactome.	BTK SHB SHE PLCG1 KIT VAV1	4.29e-08	73	92	6	24728074
Pubmed	Cytoplasmic Metadherin (MTDH) provides survival advantage under conditions of stress by acting as RNA-binding protein.	NPC1 DOCK2 CLMN LRP5 ACTN1 EML1 NEB WNK2	1.08e-07	214	92	8	22199357
Pubmed	SRGAP1 Controls Small Rho GTPases To Regulate Podocyte Foot Process Maintenance.	SRGAP3 SRGAP1 SRGAP2	3.56e-07	6	92	3	33514561
Pubmed	Signal transduction in neuronal migration: roles of GTPase activating proteins and the small GTPase Cdc42 in the Slit-Robo pathway.	SRGAP3 SRGAP1 SRGAP2	3.56e-07	6	92	3	11672528
Pubmed	Evidence for a role of srGAP3 in the positioning of commissural axons within the ventrolateral funiculus of the mouse spinal cord.	SRGAP3 SRGAP1 SRGAP2	6.22e-07	7	92	3	21655271
Pubmed	Shb links SLP-76 and Vav with the CD3 complex in Jurkat T cells.	SHB PLCG1 VAV1	6.22e-07	7	92	3	12084069
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	NPC1 ZNF487 LARP4B HDAC6 NRDC CLMN EIF4A2 SPIRE1 SDF4 SRGAP2 PLCG1 IK THOC2 KIF13A	9.86e-07	1084	92	14	11544199
Pubmed	Transcriptional activation of the NF-kappaB p65 subunit by mitogen- and stress-activated protein kinase-1 (MSK1).	RPS6KA4 PRKACA PRKACB	9.94e-07	8	92	3	12628924
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	NPC1 MYOF CELSR1 VWA8 RNPEPL1 POMGNT1 RAPGEF1 LRP5 SPIRE1 SDF4 SRGAP2 PLCG1 WNK2 TBC1D9	1.24e-06	1105	92	14	35748872
Pubmed	ZZW-115-dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents.	MYOF CAD EIF4A3 EIF4A2 PACSIN3 POLR1B SRGAP2 ACTN1 CDC5L IK THOC2	1.41e-06	660	92	11	32780723
Pubmed	Comprehensive binary interaction mapping of SH2 domains via fluorescence polarization reveals novel functional diversification of ErbB receptors.	BTK SHB SHE PLCG1 VAV1	1.97e-06	77	92	5	22973453
Pubmed	Evidence for a second isoform of the catalytic subunit of cAMP-dependent protein kinase.	PRKACA PRKACB	6.92e-06	2	92	2	3023318
Pubmed	Identification of SRGAP2 as a potential oncogene and a prognostic biomarker in hepatocellular carcinoma.	SRGAP1 SRGAP2	6.92e-06	2	92	2	33984363
Pubmed	Expression of Kit and Etv1 in restricted brain regions supports a brain-cell progenitor as an origin for cranial germinomas.	ETV1 KIT	6.92e-06	2	92	2	25736805
Pubmed	Vav1 oncogenic mutation inhibits T cell receptor-induced calcium mobilization through inhibition of phospholipase Cγ1 activation.	PLCG1 VAV1	6.92e-06	2	92	2	22474331
Pubmed	Slit-Robo GTPase-activating proteins are differentially expressed in murine dorsal root ganglia: modulation by peripheral nerve injury.	SRGAP3 SRGAP1	6.92e-06	2	92	2	22271578
Pubmed	Investigation of -PRKACA/-PRKACB fusion genes in oncocytic tumors of the pancreatobiliary and other systems.	PRKACA PRKACB	6.92e-06	2	92	2	36152045
Pubmed	PRKACA/PRKACB Fusions in Pancreatobiliary Intraductal Oncocytic Papillary Neoplasms Including Those With Atypical Morphology: An Analysis of 22 Cases Expanding Morphologic Spectrum.	PRKACA PRKACB	6.92e-06	2	92	2	38841868
Pubmed	The inverse F-BAR domain protein srGAP2 acts through srGAP3 to modulate neuronal differentiation and neurite outgrowth of mouse neuroblastoma cells.	SRGAP3 SRGAP2	6.92e-06	2	92	2	23505444
Pubmed	Molecular and behavioral effects of a null mutation in all PKA C beta isoforms.	PRKACA PRKACB	6.92e-06	2	92	2	12139926
Pubmed	Characterization of genomic clones coding for the C alpha and C beta subunits of mouse cAMP-dependent protein kinase.	PRKACA PRKACB	6.92e-06	2	92	2	2833513
Pubmed	ETV1 is a lineage survival factor that cooperates with KIT in gastrointestinal stromal tumours.	ETV1 KIT	6.92e-06	2	92	2	20927104
Pubmed	Global consequences of activation loop phosphorylation on protein kinase A.	PRKACA PRKACB	6.92e-06	2	92	2	19965870
Pubmed	AR-42, a novel HDAC inhibitor, exhibits biologic activity against malignant mast cell lines via down-regulation of constitutively activated Kit.	HDAC6 KIT	6.92e-06	2	92	2	20233974
Pubmed	Protein kinase A translocation and insulin secretion in pancreatic beta-cells: studies with adenylate cyclase toxin from Bordetella pertussis.	PRKACA PRKACB	6.92e-06	2	92	2	12180908
Pubmed	Autophosphorylation of the mammalian multifunctional protein that initiates de novo pyrimidine biosynthesis.	CAD PRKACA	6.92e-06	2	92	2	11986331
Pubmed	Recurrent Rearrangements in PRKACA and PRKACB in Intraductal Oncocytic Papillary Neoplasms of the Pancreas and Bile Duct.	PRKACA PRKACB	6.92e-06	2	92	2	31678302
Pubmed	Systems-level identification of PKA-dependent signaling in epithelial cells.	PRKACA PRKACB	6.92e-06	2	92	2	28973931
Pubmed	Signal transduction by normal isoforms and W mutant variants of the Kit receptor tyrosine kinase.	PLCG1 KIT	6.92e-06	2	92	2	1714377
Pubmed	Gene Rearrangement and Expression of PRKACA and PRKACB Govern Morphobiology of Pancreatobiliary Oncocytic Neoplasms.	PRKACA PRKACB	6.92e-06	2	92	2	37871652
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	ZC3H14 LARP4B IARS2 CAD ANAPC1 ACTN1 LAS1L IK ECPAS THOC2	9.20e-06	653	92	10	22586326
Pubmed	Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.	DOCK2 PSMD6 MYOF GUF1 IARS2 CAD EIF4A3 PRKACA ACTN1 EML1 ECPAS	9.56e-06	807	92	11	30575818
Pubmed	Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening.	SRGAP3 SRGAP1 BTK SRGAP2	9.62e-06	50	92	4	19807924
Pubmed	Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation.	PLCG1 KIT VAV1	9.78e-06	16	92	3	10022833
Pubmed	A Single Adaptable Cochaperone-Scaffold Complex Delivers Nascent Iron-Sulfur Clusters to Mammalian Respiratory Chain Complexes I-III.	NPC1 GUF1 IARS2 CELSR1 CAD VWA8 CLMN RTCA SDF4 PLCG1	1.41e-05	686	92	10	28380382
Pubmed	KAP1 facilitates reinstatement of heterochromatin after DNA replication.	TRAPPC11 IARS2 CAD EIF4A3 EIF4A2 RTCA POLR1B SDF4 PLCG1 IK	1.76e-05	704	92	10	29955894
Pubmed	Molecular cloning of a tissue-specific protein kinase (C gamma) from human testis--representing a third isoform for the catalytic subunit of cAMP-dependent protein kinase.	PRKACA PRKACB	2.07e-05	3	92	2	2342480
Pubmed	The WRP component of the WAVE-1 complex attenuates Rac-mediated signalling.	ARHGAP4 SRGAP3	2.07e-05	3	92	2	12447388
Pubmed	Substrate recognition of PLCγ1 via a specific docking surface on Itk.	BTK PLCG1	2.07e-05	3	92	2	23219468
Pubmed	Translocation of PKC[theta] in T cells is mediated by a nonconventional, PI3-K- and Vav-dependent pathway, but does not absolutely require phospholipase C.	PLCG1 VAV1	2.07e-05	3	92	2	11956228
Pubmed	A genetic test of the effects of mutations in PKA on mossy fiber LTP and its relation to spatial and contextual learning.	PRKACA PRKACB	2.07e-05	3	92	2	8548807
Pubmed	The Neuronal Migration Factor srGAP2 Achieves Specificity in Ligand Binding through a Two-Component Molecular Mechanism.	ARHGAP4 SRGAP2	2.07e-05	3	92	2	26365803
Pubmed	The paradoxical increase in cortisol secretion induced by dexamethasone in primary pigmented nodular adrenocortical disease involves a glucocorticoid receptor-mediated effect of dexamethasone on protein kinase A catalytic subunits.	PRKACA PRKACB	2.07e-05	3	92	2	19383776
Pubmed	The MATK tyrosine kinase interacts in a specific and SH2-dependent manner with c-Kit.	PLCG1 KIT	2.07e-05	3	92	2	7536744
Pubmed	DOCK5 functions as a key signaling adaptor that links FcεRI signals to microtubule dynamics during mast cell degranulation.	DOCK2 KIT	2.07e-05	3	92	2	24913231
Pubmed	Platelet-Derived Growth Factor Receptor-α Regulates Proliferation of Gastrointestinal Stromal Tumor Cells With Mutations in KIT by Stabilizing ETV1.	ETV1 KIT	2.07e-05	3	92	2	25865047
Pubmed	The Steel/W transduction pathway: kit autophosphorylation and its association with a unique subset of cytoplasmic signaling proteins is induced by the Steel factor.	PLCG1 KIT	2.07e-05	3	92	2	1710023
Pubmed	Mitochondrial biogenesis is transcriptionally repressed in lysosomal lipid storage diseases.	NPC1 ETV1	2.07e-05	3	92	2	30775969
Pubmed	Active cAMP-dependent protein kinase incorporated within highly purified HIV-1 particles is required for viral infectivity and interacts with viral capsid protein.	PRKACA PRKACB	2.07e-05	3	92	2	12842892
Pubmed	Combined inhibition of MAP kinase and KIT signaling synergistically destabilizes ETV1 and suppresses GIST tumor growth.	ETV1 KIT	2.07e-05	3	92	2	25572173
Pubmed	Involvement of the catalytic subunit of protein kinase A and of HA95 in pre-mRNA splicing.	PRKACA PRKACB	2.07e-05	3	92	2	17594903
Pubmed	Regulation of the ETS transcription factor ER81 by the 90-kDa ribosomal S6 kinase 1 and protein kinase A.	PRKACA ETV1	2.07e-05	3	92	2	12213813
Pubmed	Epidermal growth factor receptor levels are reduced in mice with targeted disruption of the protein kinase A catalytic subunit.	PRKACA PRKACB	2.07e-05	3	92	2	18380891
Pubmed	Bruton's Tyrosine Kinase (BTK) and Vav1 contribute to Dectin1-dependent phagocytosis of Candida albicans in macrophages.	BTK VAV1	2.07e-05	3	92	2	23825946
Pubmed	Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.	HDAC6 RAPGEF1 POLR1B PLCG1 THOC2 KIF13A WNK2	2.80e-05	329	92	7	17474147
Pubmed	HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease.	PRKACA PRKACB PLCG1	3.05e-05	23	92	3	9730685
Pubmed	The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications for HIV-1-associated neurological diseases.	PRKACA PRKACB PLCG1	3.05e-05	23	92	3	9278385
Pubmed	Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.	DOCK2 ARHGAP4 ZC3H14 SRGAP3 EIF4A3 SRGAP1 PRKACA PRKACB SRGAP2 ECPAS VAV1	3.07e-05	916	92	11	32203420
Pubmed	HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.	MED20 ZC3H14 MYOF CAD VWA8 EIF4A3 KDM2B EML1 ECPAS KIF13A	3.15e-05	754	92	10	35906200
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	NPC1 GABRD GUF1 HDAC6 EIF4A3 EIF4A2 ABCC5 SRGAP2 PLCG1 ACTN1 UBASH3A ZEB2 RYR3	3.34e-05	1285	92	13	35914814
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	PRUNE2 MAN2B2 KCND3 CLMN SHB PRKACB ETV1 LRP5 SPIRE1 SRGAP2 PLCG1 ECPAS MMP16 WNK2	3.61e-05	1489	92	14	28611215
Pubmed	Requirement of the Src homology 2 domain protein Shb for T cell receptor-dependent activation of the interleukin-2 gene nuclear factor for activation of T cells element in Jurkat T cells.	SHB PLCG1	4.14e-05	4	92	2	10488157
Pubmed	Dock2 generates characteristic spatiotemporal patterns of Rac activity to regulate neutrophil polarisation, migration and phagocytosis.	DOCK2 VAV1	4.14e-05	4	92	2	37383235
Pubmed	GPCR signaling inhibits mTORC1 via PKA phosphorylation of Raptor.	PRKACA PRKACB	4.14e-05	4	92	2	31112131
Pubmed	Tr-kit promotes the formation of a multimolecular complex composed by Fyn, PLCgamma1 and Sam68.	PLCG1 KIT	4.14e-05	4	92	2	14647465
Pubmed	DOCK2 associates with CrkL and regulates Rac1 in human leukemia cell lines.	DOCK2 VAV1	4.14e-05	4	92	2	12393632
Pubmed	Discrete control of TRPV4 channel function in the distal nephron by protein kinases A and C.	PRKACA PRKACB	4.14e-05	4	92	2	23709216
Pubmed	Germline and Mosaic Variants in PRKACA and PRKACB Cause a Multiple Congenital Malformation Syndrome.	PRKACA PRKACB	4.14e-05	4	92	2	33058759
Pubmed	Differential role of PKA catalytic subunits in mediating phenotypes caused by knockout of the Carney complex gene Prkar1a.	PRKACA PRKACB	4.14e-05	4	92	2	21852354
Pubmed	The SH3 domain of Bruton's tyrosine kinase interacts with Vav, Sam68 and EWS.	BTK VAV1	4.14e-05	4	92	2	9201297
Pubmed	An inhibitor of the acetyltransferases CBP/p300 exerts antineoplastic effects on gastrointestinal stromal tumor cells.	ETV1 KIT	4.14e-05	4	92	2	27633918
Pubmed	Btk plays a crucial role in the amplification of Fc epsilonRI-mediated mast cell activation by kit.	BTK KIT	4.14e-05	4	92	2	16176929
Pubmed	Phosphorylation and activation of hamster carbamyl phosphate synthetase II by cAMP-dependent protein kinase. A novel mechanism for regulation of pyrimidine nucleotide biosynthesis.	CAD PRKACA	4.14e-05	4	92	2	4092695
Pubmed	Protein kinase A-induced phosphorylation of the p65 subunit of nuclear factor-kappaB promotes Schwann cell differentiation into a myelinating phenotype.	PRKACA PRKACB	4.14e-05	4	92	2	18385332
Pubmed	Cloning of a mouse protein kinase A catalytic subunit pseudogene and chromosomal mapping of C subunit isoforms.	PRKACA PRKACB	4.14e-05	4	92	2	7873880
Pubmed	Glucose-dependent regulation of AMP-activated protein kinase in MIN6 beta cells is not affected by the protein kinase A pathway.	PRKACA PRKACB	4.14e-05	4	92	2	23116618
Pubmed	Role of caveolin-1 in the modulation of lipolysis and lipid droplet formation.	PRKACA PRKACB	4.14e-05	4	92	2	15111495
Pubmed	Tr-kit-induced resumption of the cell cycle in mouse eggs requires activation of a Src-like kinase.	PLCG1 KIT	4.14e-05	4	92	2	12374739
Pubmed	Formation of signal transfer complexes between stem cell and platelet-derived growth factor receptors and SH2 domain proteins in vitro.	PLCG1 KIT	4.14e-05	4	92	2	7537096
Pubmed	The Shb adaptor protein binds to tyrosine 766 in the FGFR-1 and regulates the Ras/MEK/MAPK pathway via FRS2 phosphorylation in endothelial cells.	SHB SHE	4.14e-05	4	92	2	12181353
Pubmed	Nuclear association of tyrosine-phosphorylated Vav to phospholipase C-gamma1 and phosphoinositide 3-kinase during granulocytic differentiation of HL-60 cells.	PLCG1 VAV1	4.14e-05	4	92	2	9891995
Pubmed	Molecular structure of the sarcomeric Z-disk: two types of titin interactions lead to an asymmetrical sorting of alpha-actinin.	ACTN1 NEB	4.14e-05	4	92	2	9501083
Pubmed	MKRN2 Physically Interacts with GLE1 to Regulate mRNA Export and Zebrafish Retinal Development.	ZC3H14 LARP4B CAD HDAC6 EIF4A3 EML1 CDC5L	4.78e-05	358	92	7	32460013
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	CAD ANAPC1 SRGAP3 EIF4A2 PRKACA PRKACB SRGAP2 EML1 CDC5L ZEB2 WNK2	4.83e-05	963	92	11	28671696
Pubmed	A high-resolution molecular atlas of the fetal mouse lower urogenital tract.	ETV1 LRP5 KIT ZEB2	4.83e-05	75	92	4	21905163
Pubmed	Binding of the proline-rich segment of myelin basic protein to SH3 domains: spectroscopic, microarray, and modeling studies of ligand conformation and effects of posttranslational modifications.	BTK NEB VAV1	5.59e-05	28	92	3	18067320
Pubmed	Wnt regulation: exploring Axin-Disheveled interactions and defining mechanisms by which the SCF E3 ubiquitin ligase is recruited to the destruction complex.	PSMD6 IARS2 CAD ANAPC1 EIF4A3 SDF4 PLCG1 CDC5L ECPAS THOC2	5.67e-05	809	92	10	32129710
Pubmed	Luzp4 defines a new mRNA export pathway in cancer cells.	EIF4A3 SRGAP2 ACTN1 THOC2	6.22e-05	80	92	4	25662211
Pubmed	Developmentally acquired PKA localisation in mouse oocytes and embryos.	PRKACA PRKACB	6.89e-05	5	92	2	18367160
Pubmed	Physical and functional characterization of the genetic locus of IBtk, an inhibitor of Bruton's tyrosine kinase: evidence for three protein isoforms of IBtk.	BTK PLCG1	6.89e-05	5	92	2	18596081
Pubmed	Btk is required for an efficient response to erythropoietin and for SCF-controlled protection against TRAIL in erythroid progenitors.	BTK KIT	6.89e-05	5	92	2	15007095
Pubmed	Involvement of protein kinase A in patterning of the mouse somatosensory cortex.	PRKACA PRKACB	6.89e-05	5	92	2	16707791
Pubmed	Histone demethylase KDM2B regulates lineage commitment in normal and malignant hematopoiesis.	KDM2B KIT	6.89e-05	5	92	2	26808549
Pubmed	HIV-1 Tat binds to SH3 domains: cellular and viral outcome of Tat/Grb2 interaction.	PRKACA PRKACB	6.89e-05	5	92	2	21745501
Pubmed	Protein kinases A and C in post-mortem prefrontal cortex from persons with major depression and normal controls.	PRKACA PRKACB	6.89e-05	5	92	2	19573263
Pubmed	Synergistic activation of PKD by the B cell antigen receptor and CD19 requires PI3K, Vav1 and PLCgamma.	PLCG1 VAV1	6.89e-05	5	92	2	16380231
Interaction	VAV1 interactions	DOCK2 CAD SRGAP1 BTK SHB SRGAP2 PLCG1 ECPAS KIT VAV1	5.27e-08	228	87	10	int:VAV1
Interaction	TOP3B interactions	NPC1 MYOF LARP4B CELSR1 CAD VWA8 ATP6AP2 RNPEPL1 EIF4A2 PRKACA POMGNT1 RAPGEF1 LRP5 SPIRE1 SDF4 SRGAP2 PLCG1 ACTN1 THOC2 WNK2 TBC1D9	8.18e-07	1470	87	21	int:TOP3B
Interaction	THOC2 interactions	MED20 ZC3H14 EIF4A3 SDF4 CDC5L IK ECPAS THOC2	4.79e-06	219	87	8	int:THOC2
Interaction	FYN interactions	NPC1 PRUNE2 CAD HDAC6 BTK PRKACA PRKACB PLCG1 KIT VAV1	1.66e-05	431	87	10	int:FYN
Interaction	KHDRBS1 interactions	DOCK2 PSMD6 HDAC6 BTK PACSIN3 PLCG1 CDC5L KIT VAV1	3.33e-05	373	87	9	int:KHDRBS1
Interaction	WAS interactions	BTK PACSIN3 SRGAP2 PLCG1 UBASH3A	4.17e-05	89	87	5	int:WAS
Interaction	RAC1 interactions	DOCK2 ARHGAP4 MYOF HDAC6 SRGAP3 ATP6AP2 SRGAP1 SHB PRKACA PACSIN3 ABCC5 RAPGEF1 LRP5 SRGAP2 VAV1	4.56e-05	1063	87	15	int:RAC1
Interaction	ZAP70 interactions	SHB PLCG1 UBASH3A KIT VAV1	4.89e-05	92	87	5	int:ZAP70
Interaction	BLNK interactions	BTK PLCG1 KIT VAV1	5.45e-05	48	87	4	int:BLNK
Interaction	MTDH interactions	NPC1 DOCK2 LARP4B CLMN LRP5 ACTN1 EML1 LAS1L NEB WNK2	6.35e-05	505	87	10	int:MTDH
Interaction	GLI2 interactions	HDAC6 SRGAP1 KDM2B SRGAP2 VAV1	6.94e-05	99	87	5	int:GLI2
Interaction	PLCG2 interactions	BTK PLCG1 LHX8 KIT VAV1	7.28e-05	100	87	5	int:PLCG2
Interaction	CBL interactions	CAD BTK PRKACA PRKACB RAPGEF1 PLCG1 ACTN1 UBASH3A KIT VAV1	7.60e-05	516	87	10	int:CBL
Interaction	POM121L1P interactions	MAN2B2 RNPEPL1	1.10e-04	4	87	2	int:POM121L1P
Interaction	DKKL1 interactions	CELSR1 VWA8 ATP6AP2 LRP5 ITIH2	1.19e-04	111	87	5	int:DKKL1
Interaction	SOS2 interactions	ZC3H14 PACSIN3 PLCG1 UBASH3A	1.23e-04	59	87	4	int:SOS2
Interaction	ABL1 interactions	BTK SHB RAPGEF1 SHE PLCG1 KIT VAV1	1.30e-04	259	87	7	int:ABL1
Interaction	CBLB interactions	PSMD6 BTK UBASH3A KIT VAV1	1.41e-04	115	87	5	int:CBLB
Interaction	B3GNT7 interactions	GHITM POMGNT1 ITIH2	1.47e-04	24	87	3	int:B3GNT7
Interaction	RAP1B interactions	HDAC6 ATP6AP2 GHITM PRKACA RAPGEF1 SDF4	1.50e-04	185	87	6	int:RAP1B
Interaction	NUPR1 interactions	MYOF CAD EIF4A3 EIF4A2 PACSIN3 POLR1B SRGAP2 ACTN1 CDC5L IK THOC2	1.69e-04	683	87	11	int:NUPR1
Interaction	RHOA interactions	PITPNM1 NPC1 MED20 MYOF CAD ATP6AP2 EIF4A3 SRGAP1 GHITM PRKACA PACSIN3 ABCC5 LRP5 PLCG1 VAV1	1.75e-04	1199	87	15	int:RHOA
Interaction	NEK3 interactions	CPNE2 HDAC6 VAV1	1.88e-04	26	87	3	int:NEK3
Interaction	HCK interactions	BTK RAPGEF1 PLCG1 KIT TOX2 VAV1	1.89e-04	193	87	6	int:HCK
Interaction	ALPI interactions	HDAC6 EIF4A2 RTCA GHITM	2.02e-04	67	87	4	int:ALPI
Interaction	KIT interactions	BTK SHB PLCG1 KIT VAV1	2.08e-04	125	87	5	int:KIT
Interaction	IBTK interactions	LARP4B EIF4A2 BTK PLCG1 ECPAS	2.16e-04	126	87	5	int:IBTK
Interaction	HSP90AB1 interactions	TRAPPC11 IARS2 RPS6KA4 HDAC6 BTK MYO3B PRKACA PRKACB PLCG1 ACTN1 CDC5L NEB THOC2	2.33e-04	960	87	13	int:HSP90AB1
GeneFamily	Rho GTPase activating proteins\|F-BAR domain containing	ARHGAP4 SRGAP3 SRGAP1 PACSIN3 SRGAP2	1.64e-08	23	65	5	1288
GeneFamily	Rho GTPase activating proteins\|BCH domain containing	ARHGAP4 SRGAP3 SRGAP1 SRGAP2	3.09e-05	50	65	4	721
GeneFamily	SH2 domain containing	BTK SHB SHE PLCG1 VAV1	3.12e-05	101	65	5	741
GeneFamily	F-box and leucine rich repeat proteins	KDM2B FBXL5	2.56e-03	21	65	2	558
GeneFamily	Endogenous ligands\|Matrix metallopeptidases	MMP13 MMP16	3.34e-03	24	65	2	891
GeneFamily	Immunoglobulin heavy locus at 14q32.33	IGHV2-70 IGHV2-26 IGHV2-5 IGHV2-70D	4.59e-03	187	65	4	349
GeneFamily	EF-hand domain containing	SDF4 PLCG1 TBC1D9 RYR3	7.97e-03	219	65	4	863
GeneFamily	DEAD-box helicases	EIF4A3 EIF4A2	9.99e-03	42	65	2	499
Coexpression	GSE3982_BASOPHIL_VS_TH1_UP	MAN2B2 VWA8 EIF4A2 PRKACB IK KIT FBXL5	5.74e-06	199	90	7	M5564
Coexpression	GSE33374_CD8_ALPHAALPHA_VS_ALPHABETA_CD161_HIGH_TCELL_DN	PITPNM1 CAD RPS6KA4 EIF4A3 PRKACB SRGAP2 VAV1	5.93e-06	200	90	7	M8533
Coexpression	NAKAYA_PBMC_FLUARIX_FLUVIRIN_AGE_18_50YO_CORRELATED_WITH_HAI_28DY_RESPONSE_AT_3DY_POSITIVE	LARP4B JAGN1 CLMN BTK PRKACA THOC2 ADA2 VAV1 FBXL5	1.61e-05	426	90	9	M41019
Coexpression	GSE32255_WT_UNSTIM_VS_JMJD2D_KNOCKDOWN_4H_LPS_STIM_DC_DN	PSMD6 ATP6AP2 SHE EML1 KIT FBXL5	2.98e-05	173	90	6	M8909
Coexpression	GSE4590_LARGE_PRE_BCELL_VS_VPREB_POS_LARGE_PRE_BCELL_UP	NPC1 CPNE2 MYOF KIT ZEB2 SLC27A2	3.08e-05	174	90	6	M6877
ToppCell	droplet-Lung-nan-3m-Myeloid-Alveolar_Macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NPC1 PRUNE2 MYOF CLMN ABCC5 ACTN1 TBC1D9	9.96e-08	183	91	7	ec3c05b9ce1e0fbb720e0dea41f1e28fd3fd878f
ToppCell	droplet-Lung-nan-3m-Myeloid-alveolar_macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NPC1 PRUNE2 MYOF CLMN ABCC5 ACTN1 TBC1D9	1.03e-07	184	91	7	3261d767d5e3d9e9fbac22ad73ca14e44beed89c
ToppCell	droplet-Lung-immune-endo-depleted-3m-Myeloid-alveolar_macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NPC1 PRUNE2 MYOF CLMN ABCC5 ACTN1 TBC1D9	1.07e-07	185	91	7	afbb88325e4a81c15ac1d0a004e3e1f4ba2ee87b
ToppCell	droplet-Liver-LIVER_HEP-30m-Myeloid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PITPNM1 MYOF BTK ZEB2 VAV1 TBC1D9	1.46e-06	172	91	6	3f784aed340b50ddbec3f7dc0a5279180d38a2bb
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MYOF CLMN SRGAP3 CECR2 ETV1 SPIRE1	2.15e-06	184	91	6	8fd8bd3d28d0ee6f0ef1f14e354d8eaf63a8081b
ToppCell	droplet-Lung-immune-endo-depleted-3m-Myeloid-Alveolar_Macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NPC1 PRUNE2 MYOF CLMN ACTN1 TBC1D9	2.22e-06	185	91	6	775b72319ef6acffd2c9a74293b9c1bccea33f42
ToppCell	Myeloid-B_(Activated_Macrophage)\|World / shred on cell class and cell subclass (v4)	MYOF BTK ABCC5 VAV1 TBC1D9 FBXL5	2.29e-06	186	91	6	33d731a7883d75e4e7db83b641cdb1e9a39938bf
ToppCell	droplet-Lung-nan-18m-Myeloid-alveolar_macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRUNE2 MYOF CLMN ABCC5 ACTN1 TBC1D9	2.37e-06	187	91	6	f0c6e53035b00772377c4d5f761b4d11026b911a
ToppCell	droplet-Lung-nan-18m-Myeloid-Alveolar_Macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRUNE2 MYOF CLMN ABCC5 ACTN1 TBC1D9	2.37e-06	187	91	6	f20e7a1751694390f535ffb27b97e887220f8695
ToppCell	droplet-Lung-LUNG-1m-Myeloid-alveolar_macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRUNE2 MYOF CLMN ABCC5 ACTN1 TBC1D9	2.52e-06	189	91	6	6d24414ac6bd4f03f7a5ad3a6eba51d549a7b112
ToppCell	LA-13._Vascular_Smooth_Muscle\|World / Chamber and Cluster_Paper	PRUNE2 MYOF KCNT2 ACTN1 KIF13A RYR3	2.52e-06	189	91	6	6b3e88751b95fc2173f2c3d5061ed632d0c5f01c
ToppCell	(07)_Brush\|World / shred by cell type and Timepoint	ARHGAP4 CLMN ETV1 KIT VAV1 WNK2	2.84e-06	193	91	6	9af9d22a130ff97a9c37142a65e841b056d08640
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Immune-Myeloid-Monocytic-Non-classical_Monocyte\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK2 BTK SRGAP2 ADA2 ZEB2 VAV1	3.01e-06	195	91	6	1d58585557bf8e9ce4d514e128d3a902b526331d
ToppCell	Parenchymal-NucSeq-Immune_Myeloid-Mast_cell\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DOCK2 BTK KIT ZEB2 VAV1 RYR3	3.48e-06	200	91	6	9156f8fd61a833891d2f7b7fadd693b81b1e2d5a
ToppCell	Parenchymal-NucSeq-Immune_Myeloid-Mast_cell-Mast_cell\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DOCK2 BTK KIT ZEB2 VAV1 RYR3	3.48e-06	200	91	6	566fe2e78e6f35399ec6aad5964f6d4d8ade82c6
ToppCell	Tracheal-NucSeq-Epithelial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CELSR1 CLMN SRGAP3 SRGAP1 LRP5 WNK2	3.48e-06	200	91	6	d3af0a706baf66e3f32e67b17dcfc31e5b32ce0e
ToppCell	Bronchial-NucSeq-Immune_Myeloid-Monocytic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DOCK2 BTK RAPGEF1 SRGAP2 ZEB2 VAV1	3.48e-06	200	91	6	8872d5fa101d413fb43b4231d476878678543035
ToppCell	COVID-19_Severe-dn_T\|COVID-19_Severe / Disease condition and Cell class	CPNE2 ATP8A2 ETV1 TOX2 SLC27A2	1.09e-05	142	91	5	2008033881b9e1b20926c3508d6ebdb6f1a1528f
ToppCell	droplet-Liver-Hepatocytes-24m-Myeloid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PITPNM1 DOCK2 GABRD SPIRE1 VAV1	1.77e-05	157	91	5	ec433d2fe827abdb647be4176c231b7052482b6f
ToppCell	facs-Kidney-nan-3m-Lymphocytic-T_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DOCK2 KIF19 UBASH3A VAV1 RYR3	2.12e-05	163	91	5	385b24e18df5ef92108483de312d6c85a1e6d145
ToppCell	facs-Kidney-nan-3m-Lymphocytic-T_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DOCK2 KIF19 UBASH3A VAV1 RYR3	2.12e-05	163	91	5	8004cc0b3428be08b89957b563cd8799f822d931
ToppCell	356C-Lymphocytic-ILC-ILC-3\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	TRAPPC11 CAD SRGAP3 TMEM161B SPIRE1	2.12e-05	163	91	5	2dbdcbc4c187aad3db837d191cc78662a75dd0b5
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Immune-Myeloid-Granulocytic-Mast_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK2 BTK KIT VAV1 RYR3	2.19e-05	164	91	5	2c48c6e4eeee845f0563982d0bfa2a176ca5ef61
ToppCell	368C-Fibroblasts-Fibroblast-C_(Myofibroblast)-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	ARHGAP4 CLMN ATP8A2 ABCC5 TOX2	2.45e-05	168	91	5	c66a61d3ec711796313a2c6d2dc39aedbfc20afd
ToppCell	facs-Liver-Hepatocytes-24m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRUNE2 BTK KIF19 SPIRE1 TBC1D9	2.45e-05	168	91	5	04e168fe1d6f5f9e3d3bf9d7c13e800e3594868a
ToppCell	368C-Fibroblasts-Fibroblast-C_(Myofibroblast)\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	ARHGAP4 CLMN ATP8A2 ABCC5 TOX2	2.45e-05	168	91	5	83b4f817d95daa15ae60668e789f97d8a3b2e6dd
ToppCell	E18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-PMP-PMP_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MAN2B2 HDAC6 SPIRE1 ACTN1 MMP16	2.52e-05	169	91	5	7cb1b87be66a22fe5731bb1b55bc515920fe3e8b
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Granulocytic-Mast_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PITPNM1 DOCK2 EIF4A3 BTK KIT	2.67e-05	171	91	5	ac37c80c832504986c7a201d84f4b6aff5e5f323
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Granulocytic\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PITPNM1 DOCK2 EIF4A3 BTK KIT	2.67e-05	171	91	5	b6502a81df4f25660f3ae4b7443a1d999df2d32b
ToppCell	Healthy_donor-Plasmablast\|World / disease group, cell group and cell class (v2)	IGHV2-5 PACSIN3 TOX2 WNK2 IGHV2-70D	2.98e-05	175	91	5	5293e00fda63a291aa393bdf82ebd4b80265049f
ToppCell	droplet-Heart-HEART_(LV+RV_ONLY)-30m-Endothelial-leukocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CPNE2 CELSR1 ATP8A2 ITIH2 RYR3	2.98e-05	175	91	5	f6e1d7297a4dbb38e1ab4f738d91f0e62abaee69
ToppCell	facs-MAT-Fat-3m-Lymphocytic-CD4-positive,_alpha-beta_T_cell\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DOCK2 ARHGAP4 CELSR1 ACTN1 UBASH3A	3.15e-05	177	91	5	b5c20c1247f11ebc97e9cb47482564cd74e36ca6
ToppCell	Healthy_donor-Plasmablast\|Healthy_donor / disease group, cell group and cell class (v2)	IGHV2-5 PACSIN3 TOX2 WNK2 IGHV2-70D	3.24e-05	178	91	5	388b8b4fa20dcc6e9ae4b06118e20b2c20c52bde
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Monocytic-Non-classical_Monocyte\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK2 BTK ADA2 ZEB2 VAV1	3.50e-05	181	91	5	8657d35cd3dff6c89d0fde67d7e7e81e1d6c8884
ToppCell	droplet-Lung-LUNG-30m-Myeloid-alveolar_macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRUNE2 MYOF CLMN ABCC5 TBC1D9	3.50e-05	181	91	5	8fcdab61fad2efd324d2b27c58f5a594f1dc15de
ToppCell	facs-Spleen-nan-3m-Lymphocytic-Cd3e_T_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CELSR1 PLCG1 ACTN1 UBASH3A NDRG3	3.50e-05	181	91	5	be7c7db6b99603759593e6f79cdcaa4bbf234cb7
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	MYOF CECR2 MYO3B ETV1 SPIRE1	3.60e-05	182	91	5	a8cc56f32efe180e8fb5d69dbe606a794b3db700
ToppCell	facs-Aorta-Heart-3m-Myeloid-macrophage\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DOCK2 BTK KIT VAV1 TBC1D9	3.60e-05	182	91	5	df26388c0c46d1c4775103c8e802937b4d4e7470
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c13-HAVCR2\|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)	CPNE2 ATP8A2 UBASH3A TOX2 SLC27A2	3.60e-05	182	91	5	6c9a48037fa002bc528875538bdaaf15696d68b6
ToppCell	droplet-Lung-LUNG-30m-Myeloid-Alveolar_Macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRUNE2 MYOF CLMN ABCC5 TBC1D9	3.60e-05	182	91	5	be48ce85991bceeff938ba080e6bf9cc62176b05
ToppCell	RA-13._Vascular_Smooth_Muscle\|RA / Chamber and Cluster_Paper	PRUNE2 MYOF CLMN ACTN1 KIF13A	3.69e-05	183	91	5	818fd886e0188091310825f9145fa53328f2c979
ToppCell	facs-Aorta-Heart-3m-Myeloid-leukocyte\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DOCK2 BTK KIT VAV1 TBC1D9	3.69e-05	183	91	5	062ec08d66c923f90fee771b1bf8d98bdc7e6c1b
ToppCell	droplet-Lung-immune-endo-depleted-3m-Myeloid-Proliferating_Alveolar_Macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRUNE2 CLMN ABCC5 ACTN1 TBC1D9	3.69e-05	183	91	5	42dc31d587fbb9724b2f0be5ee8ed77233f67b86
ToppCell	PND03-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MYOF ATP6AP2 ABCC5 VAV1 TBC1D9	3.79e-05	184	91	5	fe9ea4d0e0be820e95eaf9bb42a5560d0e177574
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CLMN SRGAP3 CECR2 MYO3B ETV1	3.79e-05	184	91	5	d33de57876817050b294f2ecb0a4eb0634cfa7f0
ToppCell	droplet-Lung-18m-Hematologic-myeloid-alveolar_macrophage\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PRUNE2 MYOF CLMN ABCC5 TBC1D9	3.79e-05	184	91	5	8fa30789c9d583188667cf375d2218e392dd40bc
ToppCell	facs-Spleen-nan-3m-Lymphocytic-CD4-positive,_alpha-beta_T_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CELSR1 ATP8A2 ACTN1 UBASH3A NDRG3	3.79e-05	184	91	5	c37c623c4a5ff1628486d8a6461fa355ad5c264c
ToppCell	droplet-Lung-18m-Hematologic-myeloid-alveolar_macrophage-alveolar_macrophage\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PRUNE2 MYOF CLMN ABCC5 TBC1D9	3.89e-05	185	91	5	4bee178ede12f56ba5f5bec44a03dc2a62c50137
ToppCell	Tuft\|World / Class top	CLMN ETV1 KIT VAV1 WNK2	3.99e-05	186	91	5	f4d83f15ab7b49c0920a322cd832413ece7c9948
ToppCell	LA-03._Atrial_Cardiomyocyte\|World / Chamber and Cluster_Paper	PRUNE2 KCND3 ACTN1 NEB WNK2	4.20e-05	188	91	5	6d249fe92d51a19da19ec14bb2262d394255d577
ToppCell	LA-13._Vascular_Smooth_Muscle\|LA / Chamber and Cluster_Paper	PRUNE2 MYOF ACTN1 KIF13A RYR3	4.20e-05	188	91	5	34e1b074a3995aa46ab194eb45115d76d1a5514d
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Monocytic-Non-classical_Monocyte\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK2 BTK ADA2 ZEB2 VAV1	4.20e-05	188	91	5	4e27ada1bda88811b73376c8a6136cbfc83bfdb9
ToppCell	droplet-Lung-30m-Hematologic-myeloid-alveolar_macrophage-alveolar_macrophage\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PRUNE2 MYOF CLMN ACTN1 TBC1D9	4.31e-05	189	91	5	98f517af255ef234eefc3ed7e6c1d63331ab8af0
ToppCell	droplet-Lung-LUNG-1m-Myeloid-Alveolar_Macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRUNE2 MYOF CLMN ABCC5 TBC1D9	4.31e-05	189	91	5	287e59104687fe1665232c52993889f0f2c97f17
ToppCell	droplet-Lung-1m-Hematologic-myeloid-alveolar_macrophage-alveolar_macrophage\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PRUNE2 MYOF CLMN ABCC5 TBC1D9	4.31e-05	189	91	5	b2542b6fcf7bc10d29158d42b03182a939ff135a
ToppCell	droplet-Lung-30m-Hematologic-myeloid-alveolar_macrophage\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PRUNE2 MYOF CLMN ACTN1 TBC1D9	4.31e-05	189	91	5	f7e9b6e6a4de297b660a5b6c9a62f860c147185e
ToppCell	Children_(3_yrs)-Immune-interstitial_macrophage_(C1Q_positive)\|Children_(3_yrs) / Lineage, Cell type, age group and donor	DOCK2 SRGAP1 ABCC5 SRGAP2 ZEB2	4.41e-05	190	91	5	f573fef3762a30c38cf8fa7f45df0ffbb49dc873
ToppCell	droplet-Lung-1m-Hematologic-myeloid-alveolar_macrophage\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PRUNE2 MYOF CLMN ABCC5 TBC1D9	4.41e-05	190	91	5	da58227565ad6a690828dd8554dd3670222f8582
ToppCell	LPS-IL1RA-Endothelial-Endothelial-Alv_Gen_Intermediate\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SHE EML1 MMP16 KIT TOX2	4.41e-05	190	91	5	106ea0bb7b99c697ffc5443d72343df2484250c7
ToppCell	LV-08._Macrophage\|World / Chamber and Cluster_Paper	DOCK2 ARHGAP4 SRGAP2 ZEB2 VAV1	4.53e-05	191	91	5	e7a0bc46ba9ba772636a583f3387748418e18832
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Immune\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK2 BTK RAPGEF1 KIT ZEB2	4.53e-05	191	91	5	468b5149d1533f03521844d3cce8633d44eb6ed4
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Monocytic-Non-classical_Monocyte\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK2 ADA2 ZEB2 VAV1 FBXL5	4.53e-05	191	91	5	47a2afc4102199b4bc76bd01b2967c8016186462
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Immune-Myeloid-Macrophage_Dendritic\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK2 BTK SRGAP2 ZEB2 VAV1	4.64e-05	192	91	5	86d792682ba51696f503c79625dd20f87bcf651f
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK2 BTK SRGAP2 ZEB2 VAV1	4.64e-05	192	91	5	d0ad6a205ad50a3c523fa68676996b289eabc5de
ToppCell	Control-Myeloid-Monocyte-derived_macrophages\|Control / group, cell type (main and fine annotations)	DOCK2 SRGAP1 RAPGEF1 SRGAP2 ZEB2	4.76e-05	193	91	5	a6b3bd01e585e2e3fbe9bf693a2e385773123f8e
ToppCell	NS-moderate-d_0-4\|moderate / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	CELSR1 CLMN SRGAP3 KIF19 DNAH9	4.76e-05	193	91	5	ea345d34440b25f65358a53dc72831998d1c3620
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MYOF CLMN SRGAP3 MYO3B ACTN1	4.76e-05	193	91	5	263d185af6ed80e639f864e4966268e0862c61dc
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Immune-Myeloid\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK2 BTK SRGAP2 ZEB2 VAV1	4.76e-05	193	91	5	f597fefc54327a1ad136e2f66b6e81cc5c761eb7
ToppCell	COPD-Myeloid-Macrophage\|World / Disease state, Lineage and Cell class	SRGAP1 RAPGEF1 SRGAP2 ZEB2 TBC1D9	4.87e-05	194	91	5	7d682408e9a6239a4e47befc9376e760cc3d133a
ToppCell	nucseq-Epithelial-Epithelial_Alveolar-Secretory/RAS\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CELSR1 SRGAP3 ABCC5 LRP5 WNK2	4.87e-05	194	91	5	0cd4363627acd419e00d6d32f6dce10430aa6487
ToppCell	nucseq-Epithelial-Epithelial_Alveolar-Secretory/RAS-RAS\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CELSR1 SRGAP3 ABCC5 LRP5 WNK2	4.87e-05	194	91	5	a58841b34efe673671a9a059238e044a7254b279
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Monocytic\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK2 BTK ADA2 ZEB2 VAV1	4.87e-05	194	91	5	badefcec2af86cbcd97305f4843e84db0f3ebc66
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK2 SRGAP1 SRGAP2 ZEB2 VAV1	4.87e-05	194	91	5	c95d5c4ad0210ebd672926558cc8331e6396a854
ToppCell	Children_(3_yrs)-Immune-monocyte-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	DOCK2 SRGAP1 SRGAP2 ZEB2 VAV1	4.99e-05	195	91	5	81a28289eda1a8a1a31b7357106f64ac5000e172
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Monocytic-Monocyte-derived_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK2 RAPGEF1 SRGAP2 ZEB2 VAV1	4.99e-05	195	91	5	62dc745e1aa3e2e58afa16c7bb2cf9b03d4e8105
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK2 ARHGAP4 SRGAP2 ZEB2 VAV1	4.99e-05	195	91	5	42bfdff88da1d07828c0ad65d412fb1752f0cee4
ToppCell	human_hepatoblastoma-Inflammatory_Monocytes\|human_hepatoblastoma / Sample and Cell Type and Tumor Cluster (all cells)	DOCK2 SRGAP1 BTK SPIRE1 ZEB2	4.99e-05	195	91	5	ba7f85e5307d96ac5ad7c952f8d094db9ca1790c
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	KCNT2 ACTN1 MMP16 ZEB2 WNK2	5.12e-05	196	91	5	1522958a92e0126326a9f0d9fb1c5b5c50b001ea
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK2 BTK ADA2 ZEB2 VAV1	5.12e-05	196	91	5	4370473693d2dd4a8c451a4c477eb79baa33ae12
ToppCell	ILEUM-non-inflamed-(3)_moDC\|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	SRGAP3 SRGAP1 ADA2 ZEB2 TBC1D9	5.12e-05	196	91	5	e10f01172fd076d6892906853f9375d4c3058951
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Monocytic\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK2 SRGAP2 ADA2 ZEB2 VAV1	5.12e-05	196	91	5	291c59b609985167c98a40d4e2caeea2fad74941
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	KCNT2 ACTN1 MMP16 ZEB2 WNK2	5.12e-05	196	91	5	1c8294014713684b50885e638668f2ce75f357f0
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Immune-Myeloid-Macrophage_Dendritic\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK2 SRGAP1 SRGAP2 ZEB2 VAV1	5.12e-05	196	91	5	cbc727b55b6433a701b1a331028a49960fcee6ee
ToppCell	PBMC-Control-cDC_3\|Control / Compartment, Disease Groups and Clusters	ZBED6 KDM2B RAPGEF1 KIT TBC1D9	5.12e-05	196	91	5	09d197b321ff9f13c0672ea059c850845b0dbbd5
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK2 RAPGEF1 SRGAP2 ZEB2 VAV1	5.24e-05	197	91	5	8af4a1e35ce9fb4ea3d26ab619599efb7eac43a5
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Immune-Myeloid\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK2 SRGAP1 SRGAP2 ZEB2 VAV1	5.24e-05	197	91	5	6ca6e17b7cc5f7ea8d4b6ca1ff670969bee65a45
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Immune-Myeloid-Monocytic-Monocyte-derived_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK2 SRGAP1 SRGAP2 ADA2 ZEB2	5.24e-05	197	91	5	dea1d29154c585ab588e50b83c7c8de7fe24d2d4
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Monocytic-Monocyte-derived_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK2 SRGAP2 ADA2 ZEB2 VAV1	5.24e-05	197	91	5	826cc6baafab13e7ef5cfcf28cd79d0fbf3af38d
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Monocytic\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK2 RAPGEF1 ADA2 ZEB2 VAV1	5.24e-05	197	91	5	1eb9ff8467118b943b5d443cb996168e1e1206b5
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Immune-Myeloid-Monocytic\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK2 SRGAP2 ADA2 ZEB2 VAV1	5.24e-05	197	91	5	72cd61b868d57862ec9c230ea68913d3829b0f2b
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-2M-IPC_like\|Organoid-2M / Sample Type, Dataset, Time_group, and Cell type.	CECR2 KIF19 SHB SPIRE1 EML1	5.37e-05	198	91	5	6d12ecaa9532c134d9c4562534dcb59a6420b4d3
ToppCell	Immune\|World / Lineage, Cell type, age group and donor	DOCK2 RAPGEF1 ADA2 ZEB2 VAV1	5.37e-05	198	91	5	65681b54d13c6997bd90a1c2a12314a80e964fe3
ToppCell	Tracheal-NucSeq-Immune_Myeloid-Mast_cell-Mast_cell\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DOCK2 BTK KIT ZEB2 VAV1	5.37e-05	198	91	5	cc5ca64749e2f4f1d373d9472824df85741702b7
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-2M-IPC_like-IPs_and_early_cortical_neurons\|Organoid-2M / Sample Type, Dataset, Time_group, and Cell type.	CECR2 KIF19 SHB SPIRE1 EML1	5.37e-05	198	91	5	7943e4f67c3d6efb5c8b00aa0ff3cfe7be10c48d
ToppCell	Tracheal-NucSeq-Immune_Myeloid-Mast_cell\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DOCK2 BTK KIT ZEB2 VAV1	5.37e-05	198	91	5	d4d66f19df078bfc3a83d4664aaf9c7789bde1a5
ToppCell	Bronchial-NucSeq-Immune_Myeloid-Macrophage_other-Macrophage_intravascular\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DOCK2 SRGAP1 ABCC5 SRGAP2 ZEB2	5.37e-05	198	91	5	c7dbf24caae5c4ef285845d13055de9e07281bb3
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK2 SRGAP2 ADA2 ZEB2 VAV1	5.50e-05	199	91	5	04adf46975aa4194ea40c7480f8a517def5d929c
ToppCell	COPD-Myeloid-Macrophage\|COPD / Disease state, Lineage and Cell class	SRGAP1 RAPGEF1 SRGAP2 ZEB2 TBC1D9	5.50e-05	199	91	5	4b9c53fb4f44190d2f6ad4d52b13be01ebe4955e
ToppCell	Tracheal-NucSeq-Immune_Myeloid-Macrophage_other-Macrophage_intravascular\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DOCK2 ARHGAP4 BTK ZEB2 VAV1	5.50e-05	199	91	5	9545ac59c8d75f5747dff86cb511a149dc103b31
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_\|World / Primary Cells by Cluster	SRGAP1 EIF4A2 PRKACB EML1 ZEB2	5.50e-05	199	91	5	058373b4ac3cec2108cb24265628ff0a50646e33
Drug	methenamine silver	PITPNM1 ARHGAP4 CELSR1 SRGAP3 SRGAP1 SPIRE1 SRGAP2 CDC5L	1.03e-06	201	87	8	CID000004101
Drug	sulprostone	CYP19A1 SHB PRKACA PRKACB PLCG1	7.74e-06	71	87	5	CID005312153
Drug	17-DMAG; Down 200; 0.1uM; MCF7; HT_HG-U133A	MAN2B2 SHB PACSIN3 POLR1B PLCG1 ACTN1 CDC5L	9.62e-06	194	87	7	6933_DN
Disease	cysteine-rich with EGF-like domain protein 1 measurement	JAGN1 SRGAP3 SRGAP2	1.32e-04	32	91	3	EFO_0021870
Disease	polycystic liver disease (implicated_via_orthology)	HDAC6 LRP5	1.96e-04	7	91	2	DOID:0050770 (implicated_via_orthology)
Disease	Fibrosis	ATP6AP2 CYP19A1 SLC27A2	5.01e-04	50	91	3	C0016059
Disease	Cirrhosis	ATP6AP2 CYP19A1 SLC27A2	5.01e-04	50	91	3	C1623038
Disease	pneumococcal bacteremia	DOCK2 ETV1	5.08e-04	11	91	2	EFO_1001925
Disease	complement factor H-related protein 1 measurement	CPNE2 KCNT2 MYO3B	6.99e-04	56	91	3	EFO_0600054
Disease	Autosomal recessive limb-girdle muscular dystrophy	TRAPPC11 POMGNT1	8.36e-04	14	91	2	cv:C2931907
Disease	early cardiac repolarization measurement	KCND3 LRP5	8.36e-04	14	91	2	EFO_0004885
Disease	essential tremor	CPNE2 TMEM161B CDC5L WNK2	8.46e-04	136	91	4	EFO_0003108
Disease	Colorectal Carcinoma	CAD KCND3 RNPEPL1 ETV1 ABCC5 SDF4 LAS1L ZEB2	1.48e-03	702	91	8	C0009402
Disease	reading and spelling ability	SRGAP3 ETV1 SRGAP2 NEB	1.77e-03	166	91	4	EFO_0005301
Disease	complement factor H-like 1 protein measurement	KCNT2 ATP8A2	2.09e-03	22	91	2	EFO_0600092
Disease	Intrahepatic Cholangiocarcinoma	PRKACA PRKACB	2.48e-03	24	91	2	C0345905
Disease	Extrahepatic Cholangiocarcinoma	PRKACA PRKACB	2.48e-03	24	91	2	C3805278
Disease	severe acute respiratory syndrome, COVID-19	KCND3 SRGAP3 ATP8A2 CECR2 MYO3B SRGAP2	2.64e-03	447	91	6	EFO_0000694, MONDO_0100096
Disease	Limb-girdle muscular dystrophy	TRAPPC11 POMGNT1	2.91e-03	26	91	2	cv:C0686353
Disease	Cholangiocarcinoma	PRKACA PRKACB	2.91e-03	26	91	2	C0206698

Protein segments in the cluster

Peptide	Gene	Start	Entry
MADYSDPSYVKQMER	CDC5L	456	Q99459
DMEKPIQVMCYDYDN	CPNE2	221	Q96FN4
MDHYDSQQTNDYMQP	ACTN1	1	P12814
EELESYMDPMNEYNA	SDF4	301	Q9BRK5
ALYDYMPMNANDLQL	BTK	221	Q06187
TMMELDYENQVAYTL	CELSR1	846	Q9NYQ6
YYQIIKAPMDISSME	CECR2	471	Q9BXF3
DTDMYYIGNDTPAMA	ATP8A2	396	Q9NTI2
MVFAGMYPLDQSEYN	GUF1	356	Q8N442
MSDLNVPEQLYQYMV	ANAPC1	1316	Q9H1A4
TGYQYPTMDELAEML	NDRG3	106	Q9UGV2
FKDNSNLYMVMEYVP	PRKACA	111	P17612
AIMPYYIGLVMTNNE	KCND3	266	Q9UK17
IYGSMEMFPAAQQLY	JAGN1	116	Q8N5M9
EEMMEEVDQVTLYSY	ITIH2	61	P19823
DSTNEYMDMKPGVSY	KIT	716	P10721
QKYDPINSMLSIYMD	GHITM	311	Q9H3K2
LTMTNMDPVDTATYY	IGHV2-70D	101	A0A0C4DH43
SKMQMGIPDDTYYEN	MFI	281	Q8NCR3
MQSNDVDIYYYMDEP	KIAA1109	286	Q2LD37
TDPSLYNMDMFYSSN	LRP5	1506	O75197
YNMDMFYSSNIPATA	LRP5	1511	O75197
LTMTNMDPVDTATYY	IGHV2-26	101	A0A0B4J1V2
DIEQYYSTQIDEMPM	EIF4A3	391	P38919
DMYLISQMDSDQYVP	LARP4B	176	Q92615
SEQMPSFPEMVYYIQ	ECPAS	551	Q5VYK3
MNLTYRIVNYTPDMT	MMP13	116	P45452
MDGFYDQQVPYMVTN	ETV1	1	P50549
DPAELMLENYDTMYL	LAS1L	661	Q9Y4W2
MLENYDTMYLLDQPV	LAS1L	666	Q9Y4W2
MLEEMAYSAYVPQDG	LHX8	306	Q68G74
YPMDEQECMLDLESY	GABRD	171	O14764
SAMMQDSPFFQQYEL	RPS6KA4	396	O75676
LTMTNMDPVDTATYY	IGHV2-70	101	P01814
FPMVYYMVGSIDNLD	KCNT2	771	Q6UVM3
LTMTNMDPVDTATYY	IGHV2-5	101	P01817
DMEYEVSMSYLEIYN	KIF19	141	Q2TAC6
DQSLSMPDDSYMVDY	NPC1	861	O15118
VSDSMKDNPHMQYYA	ABCC5	901	O15440
MDPGYDSIIYRMTNQ	ATP6AP2	331	O75787
FKDNSNLYMVMEYVP	PRKACB	111	P22694
MSMSQFVRYYETPEA	KDM2B	151	Q8NHM5
EMSKDQPDYAMYSRI	DOCK2	201	Q92608
MENFIYESMRYQPVV	CYP19A1	356	P11511
PMNIYEEQKIMFLYS	DCST1	71	Q5T197
SMQEFYEDNVLYMEI	ADA2	231	Q9NZK5
FYNTTVEEMPMNVAD	EIF4A2	391	Q14240
IARNYYPMVQSAFME	MAN2B2	751	Q9Y2E5
VTMYMPKDQVDSYSL	EML1	196	O00423
EEVFQPMLMEYFTYE	FBXL5	131	Q9UKA1
IYFIDDMNMPEVDAY	DNAH9	2541	Q9NYC9
SLEYIDLMETTQYMN	HDAC6	146	Q9UBN7
LMAAVRDNNMAPYYE	PSMD6	41	Q15008
YTPRYMEDMEQAFET	PACSIN3	216	Q9UKS6
DAVYGPADTMVQYME	MED20	181	Q9H944
PDYNYEFAQMEVIMK	KIF13A	576	Q9H1H9
ESQMSRMYTIPLYED	RNPEPL1	626	Q9HAU8
AGYMEPYEAQRIMTE	SHB	266	Q15464
LSQYSDENMMDPYNL	SRGAP1	641	Q7Z6B7
QSSYDDPSMMQLYNE	PRUNE2	1076	Q8WUY3
TEVYYNFMKPTQEMN	TMEM161B	121	Q8NDZ6
MYVPMTEDIYNAISA	SLC27A2	601	O14975
QMITVFIDGYYEEPM	POMGNT1	331	Q8WZA1
SIPVNDMYVIDQYML	IARS2	746	Q9NSE4
HLAQYSDENMMDPYN	ARHGAP4	641	P98171
DSLTQLVQQPDMMYF	CLMN	966	Q96JQ2
PQSISEEMFYQLSNM	C12orf4	521	Q9NQ89
PMSLDEYQVAQLYMI	PITPNM1	11	O00562
YDETMEKYIPVLMAQ	TTC30B	416	Q8N4P2
AQNIMDQMPPYYAAS	THOC2	361	Q8NI27
GTEQEMLYNFYPLMA	TRAPPC11	1071	Q7Z392
TAIMAPFYQYMETDN	MMP16	261	P51512
LSQYSDENMMDPYNL	SRGAP3	641	O43295
MLAYMQLLEDYSEPQ	RAPGEF1	551	Q13905
LEDDPLYTSYSSMMA	RYR3	3571	Q15413
YQLTPYEMLMDDIRC	SPIRE1	301	Q08AE8
MEQFEMAISNIYPEN	VAV1	496	P15498
NAEMAPQIDYTVMVF	RTCA	126	O00442
LSQFSEENMMDPYNL	SRGAP2	626	O75044
MYNMFSEDPNEQELY	TBC1D9	1036	Q6ZT07
PVEYVENMCENMQLY	NRDC	561	O43847
AYEEVPTSMMYSEND	PLCG1	471	P19174
MSNSYAECYPATMDD	IK	441	Q13123
MVNYNPETVSTDYDM	CAD	971	P27708
QMIVEDMHPYNYFST	ZBED6	416	P86452
YDETMEKYIPVLMAQ	TTC30A	416	Q86WT1
AYSYQAMDLPAIMVS	TOX2	116	Q96NM4
MLEMATSEYPYSECQ	WNK2	386	Q9Y3S1
AYYAMNMEPNSDELL	ZEB2	661	O60315
ISYTGYDMEDAMIVN	POLR1B	746	Q9H9Y6
DGYMEPYDAQQMITE	SHE	226	Q5VZ18
YNIEPIMLYQDMTAR	VWA8	466	A3KMH1
QYPECLDMKLYMSQT	USP17L15	296	C9J2P7
PVMAETLQMSQDYYD	ZC3H14	441	Q6PJT7
SAQRTPYRDMMLENY	ZNF487	56	B1APH4
ALMPAESYQEYMDRC	UBASH3A	551	P57075
MLSSPEDTMYYNQLN	MYO3B	1266	Q8WXR4
FYNVNMTPSELMDEI	MYOF	246	Q9NZM1
DQIYFMQTETPEYKM	NEB	321	P20929