Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
MousePheno	short tooth root	SP6 ALPL	1.01e-05	2	45	2	MP:0030497
Domain	SPIN-2	SPIN2A SPIN2B	9.15e-06	2	57	2	IPR029564
Domain	Spin-Ssty	SPIN2A SPIN2B	9.10e-05	5	57	2	PF02513
Domain	SPIN/Ssty	SPIN2A SPIN2B	9.10e-05	5	57	2	IPR003671
Domain	-	AIPL1 LONRF3 COPS2 TTC38 SMYD2	4.18e-04	207	57	5	1.25.40.10
Domain	TPR-like_helical_dom	AIPL1 LONRF3 COPS2 TTC38 SMYD2	7.15e-04	233	57	5	IPR011990
Domain	ZINC_FINGER_C2H2_1	ZNF276 ZNF532 ZNF460 ZFP64 TUT7 ZNF184 SP6 ZNF625	2.35e-03	777	57	8	PS00028
Domain	Bromodomain_CS	SMARCA2 EP300	2.84e-03	26	57	2	IPR018359
Domain	Znf_C2H2	ZNF276 ZNF532 ZNF460 ZFP64 TUT7 ZNF184 SP6 ZNF625	2.93e-03	805	57	8	IPR007087
Domain	-	ZNF276 ZNF532 ZNF460 ZFP64 ZNF184 SP6 ZNF625	4.44e-03	679	57	7	3.30.160.60
Domain	Death	ANK3 EDARADD	4.55e-03	33	57	2	PF00531
Domain	Znf_C2H2/integrase_DNA-bd	ZNF276 ZNF532 ZNF460 ZFP64 ZNF184 SP6 ZNF625	5.00e-03	694	57	7	IPR013087
Domain	BROMODOMAIN_1	SMARCA2 EP300	5.69e-03	37	57	2	PS00633
Domain	Death_domain	ANK3 EDARADD	6.00e-03	38	57	2	IPR000488
Domain	Bromodomain	SMARCA2 EP300	6.00e-03	38	57	2	PF00439
Domain	DEATH_DOMAIN	ANK3 EDARADD	6.00e-03	38	57	2	PS50017
Domain	BROMODOMAIN_2	SMARCA2 EP300	6.95e-03	41	57	2	PS50014
Domain	BROMO	SMARCA2 EP300	7.29e-03	42	57	2	SM00297
Domain	Bromodomain	SMARCA2 EP300	7.29e-03	42	57	2	IPR001487
Domain	-	SMARCA2 EP300	7.29e-03	42	57	2	1.20.920.10
Domain	ZINC_FINGER_C2H2_2	ZNF276 ZNF532 ZNF460 ZFP64 ZNF184 SP6 ZNF625	8.98e-03	775	57	7	PS50157
Pubmed	Functional cloning of SPIN-2, a nuclear anti-apoptotic protein with roles in cell cycle progression.	SPIN2A SPIN2B	2.83e-06	2	59	2	12145692
Pubmed	Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.	ANK3 KALRN PI4KA PPFIA2 GRIA1 CIT	8.30e-06	281	59	6	28706196
Pubmed	Calnexin and the immunoglobulin binding protein (BiP) coimmunoprecipitate with AMPA receptors.	CANX GRIA1	8.48e-06	3	59	2	10461883
Pubmed	The effect of adrenocorticotropic hormone on alpha-2-macroglobulin in osteoblasts derived from human mesenchymal stem cells.	A2M ALPL	8.48e-06	3	59	2	32163666
Pubmed	Association of gonadotropin receptor precursors with the protein folding chaperone calnexin.	LHCGR CANX	8.48e-06	3	59	2	9528938
Pubmed	Hepatitis B Virus HBx Protein Mediates the Degradation of Host Restriction Factors through the Cullin 4 DDB1 E3 Ubiquitin Ligase Complex.	STRN3 ANK3 KALRN PI4KA CANX SMARCA2	1.30e-05	304	59	6	32235678
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	STRN3 SYN3 ANK3 KALRN PI4KA PPFIA2 CANX DNAJA2 GRIA1 CIT	1.99e-05	1139	59	10	36417873
Pubmed	ADAM10 hyperactivation acts on piccolo to deplete synaptic vesicle stores in Huntington's disease.	SYN3 PPFIA2 CANX DNAJA2 CIT	2.44e-05	202	59	5	33601422
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	DOCK5 PI4KA TUT7 SMARCA2 CIT	2.44e-05	202	59	5	33005030
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	STRN3 SYN3 ANK3 KALRN AMOT PI4KA PPFIA2 DNAJA2 RPS15A GRIA1 CIT	2.50e-05	1431	59	11	37142655
Pubmed	Prohibitin and the SWI/SNF ATPase subunit BRG1 are required for effective androgen antagonist-mediated transcriptional repression of androgen receptor-regulated genes.	SMARCA2 EP300	2.82e-05	5	59	2	18487222
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	CCDC88C STRN3 ANK3 KALRN PI4KA CANX DNAJA2 GRIA1 CIT	3.35e-05	963	59	9	28671696
Pubmed	HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.	A2M DOCK5 PI4KA EDARADD CANX DNAJA2 EP300 ALPL	3.93e-05	754	59	8	35906200
Pubmed	PIP3-Phldb2 is crucial for LTP regulating synaptic NMDA and AMPA receptor density and PSD95 turnover.	GRIA1 ALPL	4.23e-05	6	59	2	30867511
Pubmed	A transcriptional coregulator, SPIN·DOC, attenuates the coactivator activity of Spindlin1.	SPIN2A SPIN2B	4.23e-05	6	59	2	29061846
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	ANK3 ZNF532 KALRN SLF2 DNAJA2 CIT EP300 SMYD2 RYR3 ALPL	5.53e-05	1285	59	10	35914814
Pubmed	Requirement for SWI/SNF chromatin-remodeling complex in Tat-mediated activation of the HIV-1 promoter.	SMARCA2 EP300	5.91e-05	7	59	2	16601680
Pubmed	Regulation of estrogen receptor α by histone methyltransferase SMYD2-mediated protein methylation.	EP300 SMYD2	5.91e-05	7	59	2	24101509
Pubmed	A switch from hBrm to Brg1 at IFNγ-activated sequences mediates the activation of human genes.	SMARCA2 EP300	5.91e-05	7	59	2	21079652
Pubmed	The corepressor activity of Alien is controlled by CREB-binding protein/p300.	COPS2 EP300	5.91e-05	7	59	2	23441852
Pubmed	AnkG hemizygous mice present cognitive impairment and elevated anxiety/depressive-like traits associated with decreased expression of GABA receptors and postsynaptic density protein.	ANK3 GRIA1	7.87e-05	8	59	2	28821923
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	CCDC88C ZNF276 KALRN PI4KA SDF4 HERC1 CIT TTC38 EP300	9.63e-05	1105	59	9	35748872
Pubmed	Protein interactions regulating vesicle transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells.	CANX GOSR2	1.26e-04	10	59	2	9094723
Pubmed	Ephrin-A5 and EphA5 interaction induces synaptogenesis during early hippocampal development.	GRIA1 EPHA5	1.54e-04	11	59	2	20824214
Pubmed	Targeting HIV transcription: the quest for a functional cure.	SMARCA2 EP300	1.54e-04	11	59	2	25731772
Pubmed	A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.	ZNF276 ZNF532 ZFP64 TUT7 SP6 SMARCA2 COPS2	1.93e-04	709	59	7	22988430
Pubmed	Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development.	A2M DOCK5 CANX TUT7 SPIN2A LONRF3	1.94e-04	496	59	6	31343991
Pubmed	Identification of the hypoxia-inducible factor 2α nuclear interactome in melanoma cells reveals master proteins involved in melanoma development.	DNAJA2 SMARCA2 EP300	1.97e-04	66	59	3	23275444
Pubmed	FBXO42 facilitates Notch signaling activation and global chromatin relaxation by promoting K63-linked polyubiquitination of RBPJ.	RPS15A SMARCA2 COPS2 EP300	2.69e-04	183	59	4	36129980
Pubmed	Transcription factors and nuclear receptors interact with the SWI/SNF complex through the BAF60c subunit.	SMARCA2 EP300	2.93e-04	15	59	2	14701856
Pubmed	A comprehensive resource of interacting protein regions for refining human transcription factor networks.	ANK3 SLF2 LONRF3 RYR3	3.17e-04	191	59	4	20195357
Pubmed	A human RNA polymerase II complex containing factors that modify chromatin structure.	SMARCA2 EP300	3.34e-04	16	59	2	9710619
Pubmed	Targeting USP9X-AMPK Axis in ARID1A-Deficient Hepatocellular Carcinoma.	PRKAA2 SMARCA2	3.34e-04	16	59	2	35390516
Pubmed	Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis.	A2M CANX DNAJA2 RYR3	3.43e-04	195	59	4	17110338
Pubmed	Screening and association testing of common coding variation in steroid hormone receptor co-activator and co-repressor genes in relation to breast cancer risk: the Multiethnic Cohort.	SMARCA2 EP300	3.79e-04	17	59	2	19183483
Pubmed	Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation.	ZNF460 SMARCA2 ZNF625	3.87e-04	83	59	3	20562864
Pubmed	Systematic Affinity Purification Coupled to Mass Spectrometry Identified p62 as Part of the Cannabinoid Receptor CB2 Interactome.	PI4KA CANX DNAJA2	4.01e-04	84	59	3	31616248
Pubmed	Identification of FMRP target mRNAs in the developmental brain: FMRP might coordinate Ras/MAPK, Wnt/β-catenin, and mTOR signaling during corticogenesis.	ANK3 EP300	4.25e-04	18	59	2	33323119
Pubmed	TRIM28 interacts with EZH2 and SWI/SNF to activate genes that promote mammosphere formation.	SMARCA2 EP300	4.25e-04	18	59	2	28068325
Pubmed	Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence.	ADAMTS6 ZNF184 SPIN2B EP300	4.62e-04	211	59	4	7566098
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	FADS3 ANK3 AMOT PI4KA TUT7 SDF4 HERC1 COPS2	4.70e-04	1084	59	8	11544199
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	ZNF460 DNAJA2 SMARCA2 SDF4 BRMS1L LONRF3 EP300 ALPL	5.70e-04	1116	59	8	31753913
Pubmed	Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells.	A2M AMOT CANX DNAJA2 COPS2 ALPL	5.97e-04	613	59	6	22268729
Pubmed	Tip60- and sirtuin 2-regulated MARCKS acetylation and phosphorylation are required for diabetic embryopathy.	CANX EP300	7.00e-04	23	59	2	30655546
Pubmed	A UBE2O-AMPKα2 Axis that Promotes Tumor Initiation and Progression Offers Opportunities for Therapy.	CCNG2 PRKAA2	7.00e-04	23	59	2	28162974
Pubmed	Circular RNA FOXP1 promotes tumor progression and Warburg effect in gallbladder cancer by regulating PKLR expression.	RPS15A SMARCA2 HERC1	7.07e-04	102	59	3	31623628
Pubmed	Plasticity in the Glucagon Interactome Reveals Novel Proteins That Regulate Glucagon Secretion in α-TC1-6 Cells.	PPFIA2 CANX RPS15A GRIA1	8.32e-04	247	59	4	30713523
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	DOCK5 CCNG2 ANK3 ZNF532 PPFIA2 ZFP64 PRKAA2 SMARCA2 EP300	8.59e-04	1489	59	9	28611215
Pubmed	Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome.	ANK3 KALRN GRIA1 CIT	8.83e-04	251	59	4	27507650
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	STRN3 PI4KA CANX DNAJA2 TUT7 RPS15A BRMS1L HERC1 GOSR2	8.88e-04	1496	59	9	32877691
Pubmed	Deubiquitinating Enzyme USP9X Suppresses Tumor Growth via LATS Kinase and Core Components of the Hippo Pathway.	AMOT CIT	8.96e-04	26	59	2	28720576
Pubmed	Autism candidate gene DIP2A regulates spine morphogenesis via acetylation of cortactin.	GRIA1 EP300	1.04e-03	28	59	2	31600191
Pubmed	High glucose mediates the ChREBP/p300 transcriptional complex to activate proapoptotic genes Puma and BAX and contributes to intervertebral disc degeneration.	PRKAA2 EP300	1.12e-03	29	59	2	34461288
Pubmed	AMPK Interactome Reveals New Function in Non-homologous End Joining DNA Repair.	DOCK5 PRKAA2 SMYD2	1.16e-03	121	59	3	31900314
Pubmed	Purification and identification of G protein-coupled receptor protein complexes under native conditions.	PI4KA CANX	1.27e-03	31	59	2	17215244
Pubmed	Placing the HIRA histone chaperone complex in the chromatin landscape.	SMARCA2 EP300	1.27e-03	31	59	2	23602572
Pubmed	The synaptic vesicle cycle.	SYN3 PPFIA2	1.27e-03	31	59	2	15217342
Pubmed	Dissection of behavior and psychiatric disorders using the mouse as a model.	GRIA1 RYR3	1.27e-03	31	59	2	10767319
Pubmed	The unfolded protein response: integrating stress signals through the stress sensor IRE1α.	CANX EP300	1.27e-03	31	59	2	22013210
Pubmed	Physiological and pathophysiological characteristics of ataxin-3 isoforms.	AMOT CANX DNAJA2 RPS15A	1.34e-03	281	59	4	30455355
Pubmed	Characterization of the human COP9 signalosome complex using affinity purification and mass spectrometry.	AMOT COPS2	1.36e-03	32	59	2	18850735
Pubmed	FGF11 induced by hypoxia interacts with HIF-1α and enhances its stability.	STRN3 DNAJA2 HERC1	1.36e-03	128	59	3	28027390
Pubmed	PAK4 promotes kinase-independent stabilization of RhoU to modulate cell adhesion.	ZFP64 RPS15A ZNF625	1.42e-03	130	59	3	26598620
Pubmed	Proteome-scale Binary Interactomics in Human Cells.	STRN3 SPIN2A	1.44e-03	33	59	2	27803151
Pubmed	Enhancer recruitment of transcription repressors RUNX1 and TLE3 by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemia.	A2M SMARCA2 EP300	1.46e-03	131	59	3	34551306
Pubmed	Mitochondrial Raf1 Regulates Glutamine Catabolism.	A2M ANK3 CANX CIT	1.47e-03	288	59	4	38496616
Pubmed	Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma.	A2M PI4KA CANX DNAJA2 TUT7 CIT	1.49e-03	732	59	6	34732716
Cytoband	Xp11.1	SPIN2A SPIN2B	9.73e-06	4	59	2	Xp11.1
Cytoband	12q24	HPD CIT	4.78e-04	25	59	2	12q24
GeneFamily	Tudor domain containing\|Spindlin family	SPIN2A SPIN2B	5.24e-05	5	42	2	1089
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF276 ZNF532 ZNF460 ZFP64 ZNF184 SP6 ZNF625	1.21e-03	718	42	7	28
GeneFamily	Tudor domain containing	SPIN2A SPIN2B	3.33e-03	37	42	2	780
ToppCell	Bronchial_Biopsy-Immune-Mast_cells\|Immune / Tissue, Lineage and Cell class of Lung Cells from 10X	KALRN ADAMTS6 ZNF460 RYR3 ARMH4	2.67e-06	168	58	5	45ccc0cb42d21f4853190e8e9ed9a54aefefe738
ToppCell	343B-Lymphocytic-NK_cells-NK_cell_E\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	TXNRD1 KALRN ZNF184 BRMS1L LONRF3	3.17e-06	174	58	5	a1f745962a104c6f4b86b7e482da8755384c773a
ToppCell	343B-Lymphocytic-NK_cells-NK_cell_E\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	TXNRD1 KALRN ZNF184 BRMS1L LONRF3	3.26e-06	175	58	5	78a86cac3e6c0d115c997d1c29ee0e24af54551f
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	A2M KALRN PPFIA2 RYR3 EPHA5	4.16e-06	184	58	5	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	A2M KALRN PPFIA2 RYR3 EPHA5	4.16e-06	184	58	5	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	A2M KALRN PPFIA2 RYR3 EPHA5	4.16e-06	184	58	5	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	368C-Myeloid-Dendritic-cDC_proliferating_1\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	AMOT EDARADD ZFP64 CIT TTC38	4.39e-06	186	58	5	799903b68bc6f6205d004b44c603424b0d5f7c32
ToppCell	Control-Control-Lymphocyte-T/NK-NK_activated\|Control / Disease, condition lineage and cell class	CANX SMARCA2 PABPC1L HERC1 TTC38	5.95e-06	198	58	5	76d5fe4e5bbe6c73a6ca409b80b5c3924e07cab7
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ANK3 KALRN PPFIA2 GRIA1 HERC1	5.95e-06	198	58	5	0ff30edfd3c133a42e8cb96e1631a1143215f808
ToppCell	LPS-IL1RA+antiTNF-Endothelial-Epi-like-Gen_Cap\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ZNF460 AMOT GRIA1 MOCS1	3.53e-05	142	58	4	d52da766e031f7409eb5a7a9fa88f48e14a79d8b
ToppCell	LPS-IL1RA+antiTNF-Endothelial-Epi-like\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ZNF460 AMOT GRIA1 MOCS1	3.53e-05	142	58	4	a05b320cf182b2aaf18df7c40045dc65b659bf20
ToppCell	343B-Lymphocytic-NK_cells-NK_cell_E\|343B / Donor, Lineage, Cell class and subclass (all cells)	KALRN ZNF184 BRMS1L LONRF3	5.23e-05	157	58	4	0362c04b7b0b5017964b3a73ee678ae53e7238d7
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	A2M SYN3 ADAMTS6 ALPL	6.49e-05	166	58	4	ec719368295133da2f7ff587c5329ed6db1dd56d
ToppCell	facs-Lung-24m-Hematologic-lymphocytic-mature_NK_T_cell-mature_NK_T_cell_l22\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ANK3 KALRN PPFIA2 RYR3	6.49e-05	166	58	4	bcdaab49bde5beba750b76fdcc3781a3c12c4fff
ToppCell	facs-Lung-24m-Hematologic-lymphocytic-mature_NK_T_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ANK3 KALRN PPFIA2 RYR3	6.49e-05	166	58	4	5e3b998d740b24f790fad37350d704ca0ea10b77
ToppCell	Control-Mast_cells\|Control / group, cell type (main and fine annotations)	A2M EDARADD RYR3 EPHA5	6.96e-05	169	58	4	fdb9abca1d0f4fdc32dd8ac6231651ef34aa5afb
ToppCell	Control-Mast_cells-Mast_cells\|Control / group, cell type (main and fine annotations)	A2M EDARADD RYR3 EPHA5	7.12e-05	170	58	4	c80f6d29096c372da95a8407f402349ff1bb7018
ToppCell	droplet-Marrow-nan-3m-Myeloid-granulocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	A2M TUT7 PABPC1L EPHA5	7.45e-05	172	58	4	d354424c1f861b6607dfd63b9724f4c237b30275
ToppCell	COVID-19-Heart-Neuronal\|Heart / Disease (COVID-19 only), tissue and cell type	DOCK5 ANK3 GRIA1 CIT	7.62e-05	173	58	4	6fb5f9e6536a5d57fd8e6657b494047a2d0bc9c7
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	A2M SYN3 KALRN ADAMTS6	7.79e-05	174	58	4	3d4c05ea5719ca65e85d1f15198453034791087c
ToppCell	droplet-Heart-HEART_(LV+RV_ONLY)-30m-Endothelial-leukocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANK3 EDARADD GRIA1 RYR3	7.96e-05	175	58	4	f6e1d7297a4dbb38e1ab4f738d91f0e62abaee69
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	A2M SYN3 KALRN PPFIA2	8.14e-05	176	58	4	9bc87cd5cda2372e1bce94c9dfd408eb1dfd8d0c
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	A2M SYN3 KALRN PPFIA2	8.14e-05	176	58	4	3f8274a7ab67f9f8a8923193763a5543cfe4defa
ToppCell	LPS-antiTNF-Epithelial_alveolar-Mes-like-AT1_Progenitor\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	AMOT EDARADD GOSR2 ARMH4	8.32e-05	177	58	4	164ffbbf798defa3728197deb1a14b661490e525
ToppCell	368C-Myeloid-Dendritic-cDC_proliferating_1\|368C / Donor, Lineage, Cell class and subclass (all cells)	AMOT EDARADD CIT TTC38	8.69e-05	179	58	4	ec69e1dd897414033ba5b007aa82655a79adca6c
ToppCell	human_hepatoblastoma-Tumor_cells-T6\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	SYN3 AMOT SMARCA2 GRIA1	8.69e-05	179	58	4	14fc8ccb6b215063d747643f47d780d2b237eb67
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c07-TYROBP\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	A2M ZNF184 SPIN2B TTC38	8.88e-05	180	58	4	557453b74d4a9cc95ed1c7b9a9a58e45eb02ed6a
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	A2M DPYS SYN3 GRIA1	9.07e-05	181	58	4	9ede19228ba5c0668a9c06c915510b95585216ef
ToppCell	COVID-19-Epithelial_cells-ECM-high_epithelial\|COVID-19 / group, cell type (main and fine annotations)	A2M FADS3 ANK3 ALPL	9.47e-05	183	58	4	dc1d380bf7564f290256cb7108063d1bd2da732b
ToppCell	Posterior_cortex-Macroglia-ASTROCYTE-Gja1-Astrocyte.Gja1.Myoc_(Myoc)--\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	A2M PABPC1L SPAG16	1.00e-04	69	58	3	2fd6df70cdc7477e4a3ebdf4537279a727ab1214
ToppCell	Posterior_cortex-Macroglia-ASTROCYTE-Gja1-Astrocyte.Gja1.Myoc_(Myoc)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	A2M PABPC1L SPAG16	1.00e-04	69	58	3	8e14f411cbaea9cb9bcb9351b2421e71d5828ccc
ToppCell	Posterior_cortex-Macroglia-ASTROCYTE-Gja1-Astrocyte.Gja1.Myoc_(Myoc)-\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	A2M PABPC1L SPAG16	1.00e-04	69	58	3	bc3170409d107c39534581d2f0b8d75f93519113
ToppCell	LA-13._Vascular_Smooth_Muscle\|LA / Chamber and Cluster_Paper	A2M KALRN PPFIA2 RYR3	1.05e-04	188	58	4	34e1b074a3995aa46ab194eb45115d76d1a5514d
ToppCell	15-Distal-Mesenchymal-Pericyte\|Distal / Age, Tissue, Lineage and Cell class	SYN3 LINC-PINT PPFIA2 MOCS1	1.05e-04	188	58	4	4963382e54aac06bf5047c7d725393db70667ee7
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_myocytic-mes_ASM_(13)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	BTBD16 CCDC88C ADAMTS6 RYR3	1.05e-04	188	58	4	f54b063025d80de631382bf5326bc40aab7f7d00
ToppCell	LA-13._Vascular_Smooth_Muscle\|World / Chamber and Cluster_Paper	A2M KALRN PPFIA2 RYR3	1.07e-04	189	58	4	6b3e88751b95fc2173f2c3d5061ed632d0c5f01c
ToppCell	(1)_Osterolineage_cells-(10)_OLC-1\|World / Cell class and subclass of bone marrow stroma cells in homeostatis	FADS3 PPFIA2 SP6 ALPL	1.07e-04	189	58	4	46c5b975fb9d33017f2d9b7770d45a8bdf95baa2
ToppCell	ILEUM-non-inflamed-(7)_Endothelial_cell-(7)_Lymphatics\|(7)_Endothelial_cell / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	DOCK5 KALRN PRKAA2 SMYD2	1.09e-04	190	58	4	9ce301841ce9486701fa28eb2a9929e35d476878
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	A2M SYN3 ADAMTS6 RYR3	1.12e-04	191	58	4	b2c86cde341fe350143658c8a8a4a9edbce3f19b
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	A2M SYN3 ADAMTS6 ALPL	1.14e-04	192	58	4	3259cb89d6bcf0a3c6ff1f64d85e8a1f54124e91
ToppCell	IPF-Lymphoid-T\|World / Disease state, Lineage and Cell class	CCDC88C ANK3 LINC-PINT SMARCA2	1.14e-04	192	58	4	b25ba1f3bc842c22602b2aeed3b1b5082863e4fa
ToppCell	ILEUM-inflamed-(7)_Endothelial_cell-(7)_Lymphatics\|(7)_Endothelial_cell / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	DOCK5 KALRN AMOT SMYD2	1.14e-04	192	58	4	d43caf42ec744e895137f31ef65a990e250669d2
ToppCell	severe-low-quality_cells\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	A2M ANK3 PABPC1L HERC1	1.16e-04	193	58	4	9337bc93e3904c7fc7c93c328518bcd6453b1e8c
ToppCell	Adult-Mesenchymal-matrix_fibroblast_1_cell-D231\|Adult / Lineage, Cell type, age group and donor	A2M SYN3 GRIA1 MOCS1	1.16e-04	193	58	4	ef2f456c094e6e3c6ee81e0668c953cb8d0e1c0a
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	BTBD16 ANK3 CIT ALPL	1.19e-04	194	58	4	97534c8bba895a7913665e03ae4e5c4a6ad71daf
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	A2M SYN3 KALRN ADAMTS6	1.21e-04	195	58	4	6bdef651cf73d7381e5012d0eb3c809138fb6b92
ToppCell	IPF-Endothelial-Lymphatic\|Endothelial / Disease state, Lineage and Cell class	DOCK5 KALRN PRKAA2 SMYD2	1.21e-04	195	58	4	de88e9d22044b4b3e29676ad02b3e9299cc920ad
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	A2M KALRN ADAMTS6 RYR3	1.23e-04	196	58	4	8ad8efb631164b46f0c082572270188e5ead20bf
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	A2M KALRN ADAMTS6 RYR3	1.23e-04	196	58	4	9606ea7e42f707e69ea891b3521037613b9675f5
ToppCell	Epithelial_cells-Epithelial_cells\|World / Immune cells in Kidney/Urine in Lupus Nephritis	DPYS HPD PRKAA2 ALPL	1.28e-04	198	58	4	52e9d41a1726bc1140df6baec9f17a534448ac8b
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	A2M KALRN ADAMTS6 RYR3	1.28e-04	198	58	4	07701c73137947ed4a27e225975329235bbb8734
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	A2M KALRN ADAMTS6 RYR3	1.28e-04	198	58	4	fa84bf8533d1b91d2c2bcf06b710670605072b89
ToppCell	Epithelial_cells\|World / Immune cells in Kidney/Urine in Lupus Nephritis	DPYS HPD PRKAA2 ALPL	1.28e-04	198	58	4	eeec789d226171f30799577cc37c07bdced2e3cb
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW16-Neuronal\|GW16 / Sample Type, Dataset, Time_group, and Cell type.	ANK3 PPFIA2 GRIA1 EPHA5	1.33e-04	200	58	4	84e4565d28a02700bf7f6730d1b3a58744ca0aea
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW26-Neuronal-GABAergic_neurons\|GW26 / Sample Type, Dataset, Time_group, and Cell type.	ANK3 KALRN GRIA1 EPHA5	1.33e-04	200	58	4	bad32a95b759fad509401b07bc96a56687c2a592
ToppCell	Neuronal\|World / cells hierarchy compared to all cells using T-Statistic	ANK3 KALRN GRIA1 HERC1	1.33e-04	200	58	4	48d801219bc771d6c7e151dc88ca4c179988de85
Drug	thioridazine hydrochloride; Up 200; 10uM; MCF7; HT_HG-U133A	A2M DENND5B CCNG2 FADS3 FAXDC2 LONRF3	6.26e-06	179	58	6	5590_UP
Drug	lithium indium	SPIN2A SPIN2B	6.38e-06	2	58	2	CID011116062
Drug	scandium phosphate	SPIN2A SPIN2B	6.38e-06	2	58	2	CID006365269
Drug	rubidium nitrate	SPIN2A SPIN2B	6.38e-06	2	58	2	CID000025731
Drug	Promazine hydrochloride [53-60-1]; Down 200; 12.4uM; PC3; HT_HG-U133A	DOCK5 STRN3 SLF2 ZNF184 SMARCA2 COPS2	9.92e-06	194	58	6	4308_DN
Drug	Mevalonic-D, L acid lactone [674-26-0]; Down 200; 30.8uM; HL60; HT_HG-U133A	DENND5B CCNG2 STRN3 FADS3 SMARCA2 TTC38	1.05e-05	196	58	6	2718_DN
Drug	2-propylpentanoic acid; Down 200; 1000uM; HL60; HG-U133A	DOCK5 ADAMTS6 SLF2 ZFP64 COPS2 EP300	1.18e-05	200	58	6	409_DN
Disease	phosphate measurement	RYR3 ALPL	7.65e-05	7	57	2	EFO_0010968
Disease	BMI-adjusted leptin measurement	LINC-PINT SP6	3.79e-04	15	57	2	EFO_0007793
Disease	leptin measurement, type 2 diabetes mellitus	LINC-PINT SP6	4.32e-04	16	57	2	EFO_0005000, MONDO_0005148
Disease	body fat percentage, type 2 diabetes mellitus	LINC-PINT SP6	4.89e-04	17	57	2	EFO_0007800, MONDO_0005148
Disease	alcohol use disorder (implicated_via_orthology)	FADS3 SMARCA2 EP300 RYR3	5.56e-04	195	57	4	DOID:1574 (implicated_via_orthology)
Disease	metabolite measurement	DPYS SYN3 ANK3 HPD TTC38 ALPL	7.27e-04	560	57	6	EFO_0004725
Disease	triglyceride measurement, body fat percentage	LINC-PINT SP6	7.52e-04	21	57	2	EFO_0004530, EFO_0007800
Disease	obsolete_red blood cell distribution width	DOCK5 SYN3 KALRN TUT7 SMARCA2 HERC1 CIT EP300 ARMH4	1.04e-03	1347	57	9	EFO_0005192
Disease	body fat percentage, high density lipoprotein cholesterol measurement	LINC-PINT SP6	1.07e-03	25	57	2	EFO_0004612, EFO_0007800
Disease	response to corticosteroid	ANK3 SMARCA2	1.44e-03	29	57	2	GO_0031960
Disease	abdominal:gluteofemoral adipose tissue ratio measurement	LINC-PINT SP6	1.44e-03	29	57	2	EFO_0803320
Disease	antihyperlipidemic drug use measurement	LINC-PINT PRKAA2 SP6	1.45e-03	115	57	3	EFO_0803367

Protein segments in the cluster

Peptide	Gene	Start	Entry
HDHKMEKLGLGLDDE	EP300	1701	Q09472
KMHQDEGLRDLKQGH	AMOT	156	Q4VCS5
NHEKMKAVPVLHGEG	AIPL1	171	Q9NZN9
KLEMDGHLNRGFHQE	SDF4	66	Q9BRK5
GGKMHLREGEFEKAH	COPS2	241	P61201
HALENGGDMVHLKDL	BTBD16	361	Q32M84
MAEKQKHDGRVKIGH	PRKAA2	1	P54646
EIAHVHAEKGQSDKM	ARMH4	36	Q86TY3
EEEKMHFHNGHIKLP	EPHA5	631	P54756
MKDLGAEHLAGHEGV	CCNG2	1	Q16589
MQRHEEEAHEKGKIL	CIT	746	O14578
GTKGHEAAKLMAAHI	ADAMTS6	421	Q9UKP5
HGLLVKQEDMKGHFS	A2M	511	P01023
ENVHLEKMHNGAFRG	LHCGR	206	P22888
EKGVHSGKMDENRFV	DPYS	361	Q14117
GVHEDMGKQSTKRHE	HERC1	2401	Q15751
HKELGERHGDMLKRK	CCDC88C	1206	Q9P219
HDIMKQHCGEESIRG	LINC-PINT	66	A0A455ZAR2
EDMRGKDKIVFGNIH	KALRN	1966	O60229
KDRHNGNIMLDKKGH	PI4KA	1956	P42356
GNIMLDKKGHIIHID	PI4KA	1961	P42356
QKVHNGMDDLILDGH	GOSR2	131	O14653
HEEAQKAVVHMNGKE	PABPC1L	241	Q4VXU2
FHKVMEGIHKAIELG	MOCS1	196	Q9NZB8
HEGKAKQALHEAVEM	ALPL	341	P05186
ILEVHVDKGMKHGQR	DNAJA2	216	O60884
GHMLHNEKSKQEGHI	FAXDC2	6	Q96IV6
VRVGHMELKEGKKHT	DOCK5	301	Q9H7D0
GDKGLVLMSRAKHHA	CANX	116	P27824
LVEKMGHEAVELGHG	DENND5B	751	Q6ZUT9
MGVRPHEKHDFQKDN	ANK3	3771	Q12955
RGTKAPGHQEDHMVK	EDARADD	11	Q8WWZ3
RGDKKETNHHDEMEV	BRMS1L	6	Q5PSV4
HNEGHLKEVKMEGAR	nan	71	Q6ZN92
LHVIEMKHDGIRKIG	GRIA1	366	P42261
MNHIPKEIGHEKHRD	FADS3	341	Q9Y5Q0
KELGDHVHNLVKMGA	FTMT	206	Q8N4E7
HLEGMEPGQKVHEKR	PPFIA2	241	O75334
EMGDHLVKHGDGVKD	HPD	81	P32754
HAHAGMGKIKVENQL	SYN3	251	O14994
HRMNKHKIGNEGLAA	STRN3	276	Q13033
HQMHKPIDGIHDKGI	SMARCA2	71	P51531
KAVEHMFEGEHGSKD	SPIN2A	131	Q99865
IIEAFMKGVKEHHED	SLF2	111	Q8IX21
KHMKTHEGAKEEAAG	SP6	331	Q3SY56
DMANKIGEHMEEHGI	TXNRD1	381	Q16881
IGEHMEEHGIKFIRQ	TXNRD1	386	Q16881
MDHEEARRKHTGGKI	RPS15A	111	P62244
LLSHARGHKEKGVVM	ZNF532	661	Q9HCE3
EKLHGKMSLEHEGLA	ZNF460	116	Q14592
RKVILHQEGHMDDGL	RYR3	381	Q15413
KAVEHMFEGEHGSKD	SPIN2B	131	Q9BPZ2
LKSGEIHKLMGHENE	SPAG16	591	Q8N0X2
RGADGMKKHIKEHHE	ZNF276	446	Q8N554
DHQVKPGMDLDHQEK	RHPN2P1	281	A8MT19
AHIHEMKAEIKDGLE	TTC38	221	Q5R3I4
MGERLLESKKDHQHG	ZNF625	1	Q96I27
KKAIAIMEVAHGKDH	SMYD2	406	Q9NRG4
IDDHAKGHGSKMEKG	TUT7	36	Q5VYS8
DMERHLKIHTGDKPH	ZFP64	161	Q9NTW7
RGHFMEHQKIHTGEK	ZNF184	346	Q99676
LMDPAKVKGDGQQHH	LONRF3	376	Q496Y0