Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioncatalytic activity, acting on DNA

PMS1 BPTF ERCC4 SMUG1

7.67e-05262184GO:0140097
GeneOntologyMolecularFunctionhistone kinase activity

HIPK4 ATR

2.86e-0428182GO:0035173
GeneOntologyMolecularFunctioncatalytic activity, acting on a nucleic acid

PMS1 BPTF ERCC4 SMUG1

2.30e-03645184GO:0140640
GeneOntologyMolecularFunctioncargo receptor activity

ASGR2 CUBN

2.62e-0385182GO:0038024
GeneOntologyMolecularFunctionprotein serine kinase activity

HIPK4 ATR HIPK2

3.97e-03363183GO:0106310
GeneOntologyMolecularFunctionATP-dependent activity, acting on DNA

PMS1 BPTF

5.74e-03127182GO:0008094
GeneOntologyMolecularFunctionsingle-stranded DNA binding

ERCC4 SMUG1

6.37e-03134182GO:0003697
GeneOntologyMolecularFunctionenzyme inhibitor activity

MAPK8IP1 SERPINB8 ERCC4

6.57e-03435183GO:0004857
GeneOntologyMolecularFunctionprotein serine/threonine kinase activity

HIPK4 ATR HIPK2

7.04e-03446183GO:0004674
GeneOntologyMolecularFunctionprotein tyrosine kinase activity

HIPK4 HIPK2

7.42e-03145182GO:0004713
GeneOntologyMolecularFunctiontetrapyrrole binding

FECH CUBN

9.41e-03164182GO:0046906
MousePhenoincreased cellular sensitivity to alkylating agents

ATR ERCC4

1.28e-0416152MP:0008402
MousePhenoabnormal induced cell death

ATR HIPK2 ERCC4 SMUG1

1.28e-04256154MP:0008942
MousePhenoabsent chorion

BPTF CUBN

2.02e-0420152MP:0009593
MousePhenoincreased cellular sensitivity to DNA damaging agents

ATR ERCC4

3.44e-0426152MP:0014040
MousePhenoincreased cellular sensitivity to ultraviolet irradiation

ATR ERCC4

3.44e-0426152MP:0008410
DomainLectin_C

DGCR2 ASGR2

2.92e-0384182PF00059
DomainCLECT

DGCR2 ASGR2

2.92e-0384182SM00034
DomainC_TYPE_LECTIN_2

DGCR2 ASGR2

2.99e-0385182PS50041
DomainC-type_lectin-like

DGCR2 ASGR2

3.06e-0386182IPR001304
Domain-

DGCR2 ASGR2

3.87e-03971823.10.100.10
DomainC-type_lectin-like/link

DGCR2 ASGR2

4.03e-0399182IPR016186
DomainCTDL_fold

DGCR2 ASGR2

4.69e-03107182IPR016187
DomainKinase-like_dom

HIPK4 ATR HIPK2

1.43e-02542183IPR011009
Pubmed

Effect of tyrosine autophosphorylation on catalytic activity and subcellular localisation of homeodomain-interacting protein kinases (HIPK).

HIPK4 HIPK2

1.52e-06418225630557
Pubmed

Control of HIPK2 stability by ubiquitin ligase Siah-1 and checkpoint kinases ATM and ATR.

ATR HIPK2

2.53e-06518218536714
Pubmed

Comprehensive screen of genetic variation in DNA repair pathway genes and postmenopausal breast cancer risk.

ATR PMS1 ERCC4

5.71e-066818320496165
Pubmed

DNA damage repair machinery and HIV escape from innate immune sensing.

ATR ERCC4

7.07e-06818224795708
Pubmed

Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.

HIPK2 FARP1 ERCC4 FECH CUBN ERP44

1.22e-05108418611544199
Pubmed

Aging and chronic DNA damage response activate a regulatory pathway involving miR-29 and p53.

ATR ERCC4

1.66e-051218221522133
Pubmed

Polymorphisms of DNA repair genes and risk of non-small cell lung cancer.

ATR ERCC4

4.78e-052018216195237
Pubmed

Exploring the link between MORF4L1 and risk of breast cancer.

ATR ERCC4

6.94e-052418221466675
Pubmed

Comprehensive analysis of DNA repair gene polymorphisms and survival in patients with early stage non-small-cell lung cancer.

ATR ERCC4

8.16e-052618220731661
Pubmed

Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women.

ATR PMS1 ERCC4

8.87e-0517018319064572
Pubmed

Quality control by DNA repair.

ERCC4 SMUG1

9.49e-052818210583946
Pubmed

A field synopsis on low-penetrance variants in DNA repair genes and cancer susceptibility.

ATR ERCC4

1.67e-043718219116388
Pubmed

Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease.

FARP1 CUBN

2.26e-044318221116278
Pubmed

Comprehensive analysis of DNA repair gene variants and risk of meningioma.

ERCC4 SMUG1

3.97e-045718218270339
CoexpressionKAUFFMANN_DNA_REPAIR_GENES

ATR PMS1 ERCC4 SMUG1

1.60e-05230184M11563
CoexpressionCYCLIN_D1_UP.V1_DN

ATR ASGR2 ERCC4

2.82e-04190183M2652
CoexpressionGSE22601_DOUBLE_NEGATIVE_VS_IMMATURE_CD4_SP_THYMOCYTE_DN

DGCR2 FARP1 FECH

3.19e-04198183M6228
CoexpressionGSE25087_FETAL_VS_ADULT_TREG_UP

FARP1 UQCRH ERP44

3.19e-04198183M4641
CoexpressionMCBRYAN_PUBERTAL_BREAST_6_7WK_UP

ZBTB7B HIPK2 MAPK8IP1

3.23e-04199183MM991
CoexpressionGSE29949_MICROGLIA_VS_DC_BRAIN_DN

ZBTB7B HIPK2 SERPINB8

3.23e-04199183M8405
CoexpressionMCBRYAN_PUBERTAL_BREAST_6_7WK_UP

ZBTB7B HIPK2 MAPK8IP1

3.23e-04199183M2155
CoexpressionGSE17721_LPS_VS_CPG_2H_BMDC_DN

ZBTB7B ASGR2 ERP44

3.28e-04200183M3991
CoexpressionGSE3039_ALPHAALPHA_CD8_TCELL_VS_B2_BCELL_DN

FARP1 SERPINB8 ERP44

3.28e-04200183M6439
CoexpressionGSE22886_CD8_VS_CD4_NAIVE_TCELL_UP

ATR PMS1 FECH

3.28e-04200183M4402
CoexpressionGSE17721_POLYIC_VS_PAM3CSK4_8H_BMDC_UP

ZBTB7B HIPK2 ASGR2

3.28e-04200183M3838
CoexpressionULE_SPLICING_VIA_NOVA2

MAPK8IP1 BPTF

3.96e-0443182M1551
CoexpressionULE_SPLICING_VIA_NOVA2

MAPK8IP1 BPTF

3.96e-0443182MM666
DrugAC1L92T5

ATR ERCC4 SMUG1

1.12e-0556183CID000412123
Drugriccardin D

ATR PMS1 ERCC4

2.81e-0576183ctd:C547185
DrugN-(N-acetyl-L-prolyl)-N-nitrosoglycine

PMS1 SMUG1

3.88e-0512182CID000107959
DrugTlCl

FECH SMUG1

7.04e-0516182CID000024642
DrugHeptachlor

HIPK2 FECH UQCRH

8.72e-05111183ctd:D006533
DrugO(6)-benzylguanine

PMS1 FECH

8.96e-0518182ctd:C064976
Drugiodine

DGCR2 CUBN SMUG1

1.24e-04125183CID000000807
Drug8-oxyguanine

DGCR2 BPTF SMUG1

1.39e-04130183CID000119315
Drugangelicin

ERCC4 SMUG1

1.75e-0425182CID000010658
DrugAC1L2HGV

DGCR2 SMUG1

2.37e-0429182CID000072127
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; PC3; HT_HG-U133A

HIPK2 BPTF SERPINB8

3.57e-041791834483_DN
DrugNSC668281

DGCR2 ERCC4

3.66e-0436182CID000126592
Druggeldanamycin; Up 200; 1uM; MCF7; HT_HG-U133A_EA

HIPK2 DGCR2 ERP44

3.75e-041821831008_UP
Drug0179445-0000 [211246-22-9]; Down 200; 10uM; MCF7; HT_HG-U133A

PMS1 BPTF SMUG1

3.94e-041851834755_DN
DrugChelidonine monohydrate (+) [476-32-4]; Up 200; 10.8uM; MCF7; HT_HG-U133A

HIPK2 DGCR2 FECH

4.32e-041911836236_UP
Drugcarmustine; Up 200; 100uM; MCF7; HT_HG-U133A

ATR DGCR2 FECH

4.39e-041921836914_UP
Drugaspirin, USP; Down 200; 100uM; HL60; HT_HG-U133A

HIPK2 ASGR2 ERCC4

4.39e-041921836164_DN
DrugICI182,780; Up 200; 1uM; MCF7; HT_HG-U133A

HIPK2 DGCR2 ERCC4

4.46e-041931837490_UP
Drug(-)-Quinpirole hydrochloride [85760-74-3]; Down 200; 15.6uM; MCF7; HT_HG-U133A

HIPK2 ERCC4 ERP44

4.52e-041941833539_DN
DrugBuflomedil hydrochloride [35543-24-9]; Down 200; 11.6uM; MCF7; HT_HG-U133A

ERCC4 FECH ERP44

4.52e-041941833274_DN
DrugM-K-R

UQCRH ERP44

4.52e-0440182CID011662966
DrugO6-benzylguanine

ERCC4 FECH

4.52e-0440182CID000004578
DrugDiflunisal [22494-42-4]; Up 200; 16uM; HL60; HG-U133A

DGCR2 BPTF ERP44

4.66e-041961831990_UP
DrugICI 182,780; Down 200; 1uM; ssMCF7; HG-U133A

ATR DGCR2 ERCC4

4.66e-04196183523_DN
DrugTorsemide [56211-40-6]; Down 200; 11.4uM; MCF7; HT_HG-U133A

DGCR2 ERCC4 ERP44

4.66e-041961833517_DN
Drugoligomycin; Down 200; 1uM; MCF7; HG-U133A

DGCR2 ASGR2 SERPINB8

4.66e-04196183442_DN
DrugLisuride (S)(-) [18016-80-3]; Up 200; 11.8uM; HL60; HG-U133A

ATR DGCR2 ERCC4

4.66e-041961832046_UP
DrugMetyrapone [54-36-4]; Down 200; 17.6uM; HL60; HT_HG-U133A

HIPK2 FECH SMUG1

4.73e-041971833070_DN
DrugEthamsylate [2624-44-4]; Down 200; 15.2uM; HL60; HT_HG-U133A

HIPK2 FECH ERP44

4.73e-041971832915_DN
DrugThioridazine hydrochloride [130-61-0]; Down 200; 9.8uM; MCF7; HT_HG-U133A

ATR DGCR2 ERCC4

4.73e-041971831486_DN
DrugPropafenone hydrochloride [34183-22-7]; Down 200; 10.6uM; MCF7; HT_HG-U133A

HIPK2 FARP1 ERP44

4.73e-041971835437_DN
Drugtroglitazone; Up 200; 10uM; HL60; HT_HG-U133A

DGCR2 FECH SMUG1

4.73e-041971831173_UP
DrugDiprophylline [479-18-5]; Up 200; 15.8uM; HL60; HT_HG-U133A

HIPK2 ERP44 SMUG1

4.73e-041971831853_UP
Drugtetraethylenepentamine pentahydrochloride; Up 200; 100uM; ssMCF7; HG-U133A

DGCR2 FARP1 CUBN

4.73e-04197183498_UP
DrugChlorprothixene hydrochloride [6469-93-8]; Up 200; 11.4uM; HL60; HT_HG-U133A

HIPK2 DGCR2 ERP44

4.80e-041981831272_UP
DrugOxymetazoline hydrochloride [2315-02-8]; Up 200; 13.4uM; HL60; HG-U133A

HIPK2 ASGR2 ERCC4

4.80e-041981831431_UP
Drugcelecoxib; Up 200; 10uM; MCF7; HG-U133A

DGCR2 FARP1 ERCC4

4.80e-04198183206_UP
DrugCP-944629 [668990-94-1]; Up 200; 10uM; MCF7; HT_HG-U133A

HIPK2 FARP1 ERCC4

4.80e-041981837544_UP
DrugHexamethonium dibromide dihydrate [55-97-0]; Down 200; 10uM; MCF7; HT_HG-U133A

DGCR2 FARP1 FECH

4.80e-041981831482_DN
DrugThyroxine (L) [51-48-9]; Up 200; 5.2uM; HL60; HT_HG-U133A

ASGR2 ERP44 SMUG1

4.80e-041981831312_UP
DrugDiphemanil methylsulfate [62-97-5]; Down 200; 10.2uM; PC3; HG-U133A

HIPK2 PIGB FARP1

4.80e-041981831912_DN
DrugIsocarboxazid [59-63-2]; Down 200; 17.2uM; MCF7; HT_HG-U133A

DGCR2 ERCC4 ERP44

4.80e-041981833424_DN
DrugPhenethicillin potassium salt [132-93-4]; Down 200; 10uM; MCF7; HT_HG-U133A

DGCR2 FARP1 ERCC4

4.80e-041981836239_DN
DrugSulfasalazine [599-79-1]; Down 200; 10uM; MCF7; HT_HG-U133A

ERCC4 FECH ERP44

4.80e-041981832882_DN
DrugMeptazinol hydrochloride [59263-76-2]; Down 200; 14.8uM; MCF7; HT_HG-U133A

DGCR2 FECH SMUG1

4.87e-041991837326_DN
DrugIobenguane sulfate; Up 200; 10.8uM; HL60; HG-U133A

DGCR2 ASGR2 CUBN

4.87e-041991831729_UP
Druggenistein; Up 200; 10uM; MCF7; HG-U133A

HIPK2 FECH ERP44

4.87e-04199183638_UP
Drugmonastrol; Down 200; 100uM; PC3; HG-U133A

HIPK2 DGCR2 FARP1

4.87e-04199183668_DN
DrugAmrinone [60719-84-8]; Down 200; 21.4uM; MCF7; HT_HG-U133A

DGCR2 FARP1 FECH

4.94e-042001833465_DN
DrugOncol

MAPK8IP1 SMUG1

4.99e-0442182CID000054886
DrugAC1L1HZ7

DGCR2 BPTF

4.99e-0442182CID000004355
DiseaseNeoplasm of uncertain or unknown behavior of ovary

ATR PMS1 ERCC4

6.90e-0729183C0496920
DiseaseOvarian Carcinoma

ATR PMS1 ERCC4

7.66e-0730183C0029925
DiseaseCarcinoma in situ of endometrium

ATR PMS1

5.35e-0518182C0346191
DiseaseMalignant neoplasm of endometrium

ATR PMS1

5.35e-0518182C0007103
Diseaseovarian neoplasm

ATR PMS1 ERCC4

7.11e-05134183C0919267
DiseaseMalignant neoplasm of ovary

ATR PMS1 ERCC4

7.59e-05137183C1140680
Diseaseprimary dental caries

ERCC4 CUBN

1.95e-0434182EFO_0600095
DiseaseHypermetropia, Myopia

BPTF ERCC4 CUBN

1.97e-04189183HP_0000540, HP_0000545
DiseaseEndometrial Carcinoma

ATR PMS1

8.76e-0472182C0476089
Diseasepancreatic cancer (is_implicated_in)

ATR ERCC4

2.10e-03112182DOID:1793 (is_implicated_in)
Diseaseferritin measurement

PMS1 ASGR2

2.37e-03119182EFO_0004459
DiseaseBladder Neoplasm

BPTF ERCC4

3.25e-03140182C0005695
DiseaseMalignant neoplasm of urinary bladder

BPTF ERCC4

3.30e-03141182C0005684
Diseasebipolar I disorder

MAPK8IP1 CUBN

3.30e-03141182EFO_0009963

Protein segments in the cluster

PeptideGeneStartEntry
ADHDALLFHLKHFPV

ASGR2

141

P07307
HDKRRHLAHKFCLTP

BPTF

871

Q12830
LFDFLHARDHCVAHK

UQCRH

71

P07919
HLLDFPHSTHVKSCF

HIPK2

531

Q9H2X6
PHLLHAACKAHHFFK

HIPK4

236

Q8NE63
TKHPADHRFACHVFV

MAPK8IP1

661

Q9UQF2
EFKDFHLEHHPNCTL

CUBN

1206

O60494
AFIDNLHHLCKHLDF

ATR

781

Q13535
LERLCKHHPPSHADF

FARP1

696

Q9Y4F1
LQCFHFPTLRHHDLH

DGCR2

236

P98153
FLHADCDKFRHPLLH

ERP44

296

Q9BS26
CFADHILKELDHFPL

FECH

236

P22830
EIKECVHGRPFFHHL

PMS1

911

P54277
HFCQEPRKLDLILHH

PIGB

246

Q92521
HPFLFFIRHHKTNCI

SERPINB8

351

P50452
HCPARFLHSYDLKNH

ZBTB7B

406

O15156
FHHCFVHNLCPLLFL

SMUG1

156

Q53HV7
ADRLLYHFLQLHCHP

ERCC4

41

Q92889