Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionsnRNP binding

SNRPB SNRPN

1.64e-0416242GO:0070990
GeneOntologyMolecularFunctionmannosyltransferase activity

GTDC1 ALG8

5.13e-0428242GO:0000030
GeneOntologyBiologicalProcessendonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

UTP20 RCL1

3.62e-058242GO:0000480
GeneOntologyBiologicalProcessendonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

UTP20 RCL1

5.81e-0510242GO:0000447
GeneOntologyBiologicalProcessendonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

UTP20 RCL1

1.96e-0418242GO:0000479
GeneOntologyCellularComponentU4 snRNP

SNRPB SNRPN

8.97e-0513232GO:0005687
GeneOntologyCellularComponentU2-type prespliceosome

SNRPB SNRPN

1.75e-0418232GO:0071004
GeneOntologyCellularComponentprespliceosome

SNRPB SNRPN

1.75e-0418232GO:0071010
GeneOntologyCellularComponentU5 snRNP

SNRPB SNRPN

3.42e-0425232GO:0005682
GeneOntologyCellularComponentU2 snRNP

SNRPB SNRPN

4.30e-0428232GO:0005686
GeneOntologyCellularComponentU1 snRNP

SNRPB SNRPN

5.99e-0433232GO:0005685
GeneOntologyCellularComponentU4/U6 x U5 tri-snRNP complex

SNRPB SNRPN

1.21e-0347232GO:0046540
GeneOntologyCellularComponentspliceosomal tri-snRNP complex

SNRPB SNRPN

1.27e-0348232GO:0097526
GeneOntologyCellularComponentsmall-subunit processome

UTP20 RCL1

3.14e-0376232GO:0032040
HumanPhenoAbnormal tongue morphology

OFD1 SNRPB RTL1 ALG8 SNRPN

4.50e-0538675HP:0030809
HumanPhenoAbnormal morphology of the great vessels

OFD1 SNRPB RTL1 ALG8 SNRPN DNAH1

5.49e-0573676HP:0030962
HumanPhenoAbnormality of the tongue

OFD1 SNRPB RTL1 ALG8 SNRPN

1.38e-0448675HP:0000157
HumanPhenoAbnormality of the amniotic fluid

OFD1 SNRPB RTL1 ALG8 SNRPN

1.65e-0450475HP:0001560
HumanPhenoAlveolar ridge overgrowth

OFD1 SNRPN

1.69e-041572HP:0009085
HumanPhenoCongenital malformation of the great arteries

OFD1 SNRPB ALG8 SNRPN DNAH1

2.08e-0452975HP:0011603
DomainsnRNP-assoc_SmB/SmN

SNRPB SNRPN

1.45e-062232IPR017131
DomainSm

SNRPB SNRPN

2.45e-0419232SM00651
DomainLSM

SNRPB SNRPN

2.45e-0419232PF01423
DomainLSM_dom_euk/arc

SNRPB SNRPN

2.45e-0419232IPR001163
DomainLSM_dom

SNRPB SNRPN

3.30e-0422232IPR010920
DomainRhoGEF

FGD6 VAV3

3.15e-0368232SM00325
DomainDH_2

FGD6 VAV3

3.33e-0370232PS50010
DomainRhoGEF

FGD6 VAV3

3.33e-0370232PF00621
DomainDH-domain

FGD6 VAV3

3.42e-0371232IPR000219
Domain-

FGD6 VAV3

3.42e-03712321.20.900.10
PathwayREACTOME_METABOLISM_OF_RNA

SNRPB UTP20 SNRPN POLR2B RCL1

1.46e-04612135MM15547
PathwayREACTOME_METABOLISM_OF_RNA

SNRPB UTP20 SNRPN POLR2B RCL1

3.21e-04724135M16843
PathwayREACTOME_MRNA_SPLICING

SNRPB SNRPN POLR2B

7.35e-04201133MM15411
PathwayREACTOME_MRNA_SPLICING

SNRPB SNRPN POLR2B

8.58e-04212133M14033
PathwayREACTOME_MRNA_SPLICING_MINOR_PATHWAY

SNRPB POLR2B

8.65e-0448132MM15410
PathwayREACTOME_MRNA_SPLICING_MINOR_PATHWAY

SNRPB POLR2B

9.38e-0450132M5583
Pubmed

The cardiac form of the tissue-specific SmN protein is identical to the brain and embryonic forms of the protein.

SNRPB SNRPN

4.56e-0722428510173
Pubmed

Concerted regulation and molecular evolution of the duplicated SNRPB'/B and SNRPN loci.

SNRPB SNRPN

4.56e-07224210556313
Pubmed

A comparison of snRNP-associated Sm-autoantigens: human N, rat N and human B/B'.

SNRPB SNRPN

1.37e-0632422522186
Pubmed

Sm and Sm-like proteins belong to a large family: identification of proteins of the U6 as well as the U1, U2, U4 and U5 snRNPs.

SNRPB SNRPN

1.37e-0632427744014
Pubmed

The editing enzyme ADAR1 and the mRNA surveillance protein hUpf1 interact in the cell nucleus.

SNRPB SNRPN

4.56e-06524218362360
Pubmed

A novel function for human factor C1 (HCF-1), a host protein required for herpes simplex virus infection, in pre-mRNA splicing.

SNRPB SNRPN

9.56e-06724212456665
Pubmed

Multiple protein: protein interactions between the snRNP common core proteins.

SNRPB SNRPN

1.27e-0582429417867
Pubmed

Recognition sequences for the GYF domain reveal a possible spliceosomal function of CD2BP2.

SNRPB SNRPN

2.05e-051024215105431
Pubmed

Genomic imprinting in Dicer1-hypomorphic mice.

RTL1 SNRPN

2.50e-051124216575173
Pubmed

The methylosome, a 20S complex containing JBP1 and pICln, produces dimethylarginine-modified Sm proteins.

SNRPB SNRPN

3.00e-051224211713266
Pubmed

A functional interaction between the survival motor neuron complex and RNA polymerase II.

SNRPB SNRPN

3.54e-051324211149922
Pubmed

Gemin4. A novel component of the SMN complex that is found in both gems and nucleoli.

SNRPB SNRPN

4.13e-051424210725331
Pubmed

Generalized disruption of inherited genomic imprints leads to wide-ranging placental defects and dysregulated fetal growth.

RTL1 SLC22A2

6.94e-051824223085235
Pubmed

An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs.

SNRPB SNRPN

1.05e-042224218984161
Pubmed

Nuclear Functions of Nucleolin through Global Proteomics and Interactomic Approaches.

SNRPN POLR2B RCL1

1.35e-0414524327049334
Pubmed

The Dual Estrogen Receptor α Inhibitory Effects of the Tissue-Selective Estrogen Complex for Endometrial and Breast Safety.

PRR12 SNRPN

4.05e-044324226487511
Pubmed

Aire's partners in the molecular control of immunological tolerance.

SNRPB POLR2B

4.44e-044524220085707
Pubmed

GRWD1 regulates ribosomal protein L23 levels via the ubiquitin-proteasome system.

SNRPB POLR2B RCL1

4.64e-0422124329991511
Pubmed

KAP1 targets actively transcribed genomic loci to exert pleomorphic effects on RNA polymerase II activity.

SNRPB RCL1

5.48e-045024232068487
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

FGD6 VAV3

8.46e-0466122722
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

FGD6 VAV3

7.91e-03206122682
Diseasetauopathy (implicated_via_orthology)

SNRPB SNRPN

2.84e-0510242DOID:680 (implicated_via_orthology)
DiseasePolynesian Bronchiectasis

OFD1 DNAH1

3.71e-0435242C4317124
DiseaseCiliary Dyskinesia, Primary, 1, With Or Without Situs Inversus

OFD1 DNAH1

3.71e-0435242C4551906
DiseaseKartagener Syndrome

OFD1 DNAH1

3.71e-0435242C0022521
DiseasePrimary Ciliary Dyskinesia

OFD1 DNAH1

6.70e-0447242C4551720
Diseasecholesterol:total lipids ratio, high density lipoprotein cholesterol measurement

BANF2 SLC22A2 DNAH1

1.42e-03276243EFO_0004612, EFO_0020943
Diseaseautoimmune thyroid disease

BANF2 VAV3

4.70e-03126242EFO_0006812
Diseasetriglyceride measurement, phospholipid measurement

SLC22A2 DNAH1

6.25e-03146242EFO_0004530, EFO_0004639
Diseasetriglycerides:total lipids ratio, low density lipoprotein cholesterol measurement

BANF2 SLC22A2

6.58e-03150242EFO_0004611, EFO_0020947
Diseaseautoimmune disease

BANF2 VAV3

8.67e-03173242EFO_0005140

Protein segments in the cluster

PeptideGeneStartEntry
MKFLIFAFFGGVHLL

CPQ

1

Q9Y646
MQKALFDFLKHRFDG

CACNB3

196

P54284
MKLLKLTGFIFFLFF

AFM

1

P43652
HGLLAFFKSEKLDMI

CAPN5

266

O15484
EFLRHLKSFFQIMFK

RCL1

326

Q9Y2P8
FLGKEMKLYFAQTLH

RCAN1

131

P53805
QKGFLMHFLKELAEY

OFD1

136

O75665
SLFEKHKLMFAFLLC

DNAH1

3516

Q9P2D7
LLGQFLLMHKNEAEF

BANF2

46

Q9H503
HSFKMAFVKHLLLFL

DSCR8

16

Q96T75
FFKVLMHLKDLGLNF

GTDC1

301

Q4AE62
HFFQKQMFFLLALLS

SLC22A2

16

O15244
IHFILKDMLGFFVLS

RTL1

716

A6NKG5
LFNLMFLDLDKHPEK

UTP20

206

O75691
IFIGTFKAFDKHMNL

SNRPN

26

P63162
AFLFRGMFKNLLKEV

POLR2B

401

P30876
IFIGTFKAFDKHMNL

SNRPB

26

P14678
FMASFLDFLKSGKRH

PRR12

1281

Q9ULL5
ELALFCEGFFLKHMK

ABTB2

966

Q8N961
MEGAFLFAVLLHFKH

ALG8

186

Q9BVK2
FILKFFFMGLKCLIL

RNFT1

256

Q5M7Z0
MKSAKLGFLLRFFIF

SPINT4

1

Q6UDR6
VFQLLHKNMLFYVFK

FGD6

1396

Q6ZV73
GFFHIAENRKFKSLM

VAV3

726

Q9UKW4