Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	vasopressin receptor activity	AVPR1A INPP5K	6.23e-05	7	35	2	GO:0005000
MousePheno	abnormal Sertoli cell morphology	ADGRG1 XKR8 FNDC3A ABHD5	1.42e-05	75	28	4	MP:0002784
MousePheno	abnormal seminiferous tubule epithelium morphology	ADGRG1 XKR8 FNDC3A ABHD5	9.02e-05	120	28	4	MP:0011750
Domain	SEMA	SEMA5A PLXNB1	1.36e-03	31	33	2	PS51004
Domain	Sema	SEMA5A PLXNB1	1.36e-03	31	33	2	SM00630
Domain	Semap_dom	SEMA5A PLXNB1	1.36e-03	31	33	2	IPR001627
Domain	Sema	SEMA5A PLXNB1	1.36e-03	31	33	2	PF01403
Domain	Plexin_repeat	SEMA5A PLXNB1	1.45e-03	32	33	2	IPR002165
Domain	PSI	SEMA5A PLXNB1	1.45e-03	32	33	2	PF01437
Domain	-	MKRN3 ZFP36	2.26e-03	40	33	2	4.10.1000.10
Domain	PSI	SEMA5A PLXNB1	2.73e-03	44	33	2	IPR016201
Domain	fn3	IL11RA FNDC3A AXL	2.89e-03	162	33	3	PF00041
Domain	PSI	SEMA5A PLXNB1	2.98e-03	46	33	2	SM00423
Domain	ZnF_C3H1	MKRN3 ZFP36	3.25e-03	48	33	2	SM00356
Domain	zf-CCCH	MKRN3 ZFP36	3.38e-03	49	33	2	PF00642
Domain	FN3	IL11RA FNDC3A AXL	4.19e-03	185	33	3	SM00060
Domain	Znf_CCCH	MKRN3 ZFP36	4.70e-03	58	33	2	IPR000571
Domain	ZF_C3H1	MKRN3 ZFP36	4.70e-03	58	33	2	PS50103
Domain	FN3	IL11RA FNDC3A AXL	5.14e-03	199	33	3	PS50853
Domain	TSP_1	SEMA5A ADAMTS14	5.53e-03	63	33	2	PF00090
Domain	TSP1	SEMA5A ADAMTS14	5.87e-03	65	33	2	SM00209
Domain	TSP1_rpt	SEMA5A ADAMTS14	5.87e-03	65	33	2	IPR000884
Domain	TSP1	SEMA5A ADAMTS14	5.87e-03	65	33	2	PS50092
Domain	FN3_dom	IL11RA FNDC3A AXL	5.89e-03	209	33	3	IPR003961
Pubmed	Expression and imprinting of MAGEL2 suggest a role in Prader-willi syndrome and the homologous murine imprinting phenotype.	MKRN3 MAGEL2	3.12e-06	3	36	2	10915770
Pubmed	Prader-Willi syndrome transcripts are expressed in phenotypically significant regions of the developing mouse brain.	MKRN3 MAGEL2	6.24e-06	4	36	2	12971993
Pubmed	Plexin-B3 is a functional receptor for semaphorin 5A.	SEMA5A PLXNB1	1.04e-05	5	36	2	15218527
Pubmed	Retrotransposed genes such as Frat3 in the mouse Chromosome 7C Prader-Willi syndrome region acquire the imprinted status of their insertion site.	MKRN3 MAGEL2	1.04e-05	5	36	2	11845283
Pubmed	Deletion of the MBII-85 snoRNA gene cluster in mice results in postnatal growth retardation.	MKRN3 MAGEL2	1.56e-05	6	36	2	18166085
Pubmed	Imprinting analysis of the mouse chromosome 7C region in DNMT1-null embryos.	MKRN3 MAGEL2	2.18e-05	7	36	2	25300248
Pubmed	Smchd1 regulates a subset of autosomal genes subject to monoallelic expression in addition to being critical for X inactivation.	MKRN3 MAGEL2	2.91e-05	8	36	2	23819640
Pubmed	Human lysophosphatidylcholine acyltransferases 1 and 2 are located in lipid droplets where they catalyze the formation of phosphatidylcholine.	PLIN4 ABHD5	3.73e-05	9	36	2	21498505
Pubmed	Prader-Willi Syndrome	MKRN3 MAGEL2	4.66e-05	10	36	2	20301505
Pubmed	DNA Sequence Recognition of Human CXXC Domains and Their Structural Determinants.	KDM2B TET3	4.66e-05	10	36	2	29276034
Pubmed	The imprinted gene Magel2 regulates normal circadian output.	MKRN3 MAGEL2	4.66e-05	10	36	2	17893678
Pubmed	Global deficits in development, function, and gene expression in the endocrine pancreas in a deletion mouse model of Prader-Willi syndrome.	MKRN3 MAGEL2	1.58e-04	18	36	2	21343540
Pubmed	Transcriptional regulatory network of SOX4 during myoblast differentiation.	LMNB2 PLXNB1	1.76e-04	19	36	2	25969425
Pubmed	Class 5 transmembrane semaphorins control selective Mammalian retinal lamination and function.	SEMA5A OPN4	2.16e-04	21	36	2	21835343
Pubmed	Microarray expression profiling of tissues from mice with uniparental duplications of chromosomes 7 and 11 to identify imprinted genes.	MKRN3 MAGEL2	2.83e-04	24	36	2	11668390
Pubmed	Expression of Robo/Slit and Semaphorin/Plexin/Neuropilin family members in the developing hypothalamic paraventricular and supraoptic nuclei.	SEMA5A PLXNB1	3.87e-04	28	36	2	18617019
Pubmed	Disruption of parental-specific expression of imprinted genes in uniparental fetuses.	MKRN3 MAGEL2	4.16e-04	29	36	2	16987518
Pubmed	Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism.	MKRN3 SEMA5A KANK2 AVPR1A	7.73e-04	402	36	4	24722188
Pubmed	Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.	MKRN3 ADGRG1 PRKCSH ABHD5 SYNE4	9.51e-04	742	36	5	26871637
Pubmed	HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.	MKRN3 KDM2B FNDC3A LMNB2 KANK2	1.02e-03	754	36	5	35906200
Interaction	PAN3 interactions	TNRC6C GLDC ZFP36 CPEB1	5.37e-06	65	36	4	int:PAN3
Cytoband	19q13.1	AXL ZFP36	8.65e-04	55	36	2	19q13.1
GeneFamily	Zinc fingers CXXC-type	KDM2B TET3	1.40e-04	12	27	2	136
Coexpression	GSE1448_CTRL_VS_ANTI_VALPHA2_DP_THYMOCYTE_UP	SEMA5A LMNB2 SYNE4 UBE2Z ZFP36	7.65e-06	200	36	5	M3425
ToppCell	primary_visual_cortex-Non-neuronal-smooth_muscle_cell-SMC\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	PLIN4 ADAMTS14 KANK2 AXL ZFP36	2.08e-07	164	36	5	9eed945e9b0c1ee5fc62724ac2bbbed4267b0678
ToppCell	primary_visual_cortex-Non-neuronal-smooth_muscle_cell-SMC-SMC_Acta2\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	PLIN4 ADAMTS14 KANK2 AXL ZFP36	2.08e-07	164	36	5	f510f20e37e31b486cdd0e3f597ce4ff00877c5d
ToppCell	primary_visual_cortex-Non-neuronal-smooth_muscle_cell\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	PLIN4 ADAMTS14 KANK2 AXL ZFP36	2.08e-07	164	36	5	5c932a462cbf81d029c8d11ec3aea3191529527b
ToppCell	10x_5'_v1-Non-neoplastic-Lymphoid-NK\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	MKRN3 ABHD5 KANK2 ZFP36 PLXNB1	4.55e-07	192	36	5	930319cbd82b9e54864147ffcdc8bd0ea7b937be
ToppCell	10x_5'_v1-Non-neoplastic-Lymphoid-NK-NK\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	MKRN3 ABHD5 KANK2 ZFP36 PLXNB1	4.55e-07	192	36	5	c7bcebcb88a25b2c97d798120efa9d5958e7f798
ToppCell	3'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_2_(NPY+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MAGEL2 ADAMTS14 AXL ZFP36	1.50e-05	186	36	4	d3509a579871ba6a8c4edd6137b28f271c9dbe70
ToppCell	PND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC-VSMC_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PLIN4 IL11RA SEMA5A AXL	1.70e-05	192	36	4	26d9207e72bbef5e0046de511e2c9ff752b726f3
ToppCell	10x_5'_v1-Non-neoplastic-Lymphoid-NK-NK-Z\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	MKRN3 ABHD5 ZFP36 PLXNB1	1.77e-05	194	36	4	3211d89440a6f4a9b3d4cfb755890816944242ec
ToppCell	15-Airway\|15 / Age, Tissue, Lineage and Cell class	IL11RA SEMA5A AXL ZFP36	2.00e-05	200	36	4	ba4b8d5becf81351901c2ecac74ffa28e29586f3
ToppCell	Tracheal-NucSeq-Stromal-Pericyte-Muscle_pericyte_systemic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SEMA5A OPN4 AVPR1A AXL	2.00e-05	200	36	4	9d3ae9ea47b1017adb63aa02d10e98193d478458
ToppCell	Tracheal-NucSeq-Stromal-Pericyte\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SEMA5A OPN4 AVPR1A AXL	2.00e-05	200	36	4	78cd0b7d221ef855512ee9ac9a291f61622c2e24
Disease	Prader-Willi syndrome	MKRN3 MAGEL2	5.77e-05	10	34	2	cv:C0032897
Disease	PRADER-WILLI SYNDROME	MKRN3 MAGEL2	5.77e-05	10	34	2	176270
Disease	Royer Syndrome	MKRN3 MAGEL2	8.44e-05	12	34	2	C0265222
Disease	Prader-Willi Syndrome	MKRN3 MAGEL2	9.97e-05	13	34	2	C0032897
Disease	preterm premature rupture of the membranes, spontaneous preterm birth	FNDC3A ADAMTS14	4.78e-04	28	34	2	EFO_0006917, MONDO_0012511
Disease	Autistic Disorder	SEMA5A MAGEL2 AVPR1A	3.34e-03	261	34	3	C0004352
Disease	Autism Spectrum Disorders	AVPR1A TET3	4.33e-03	85	34	2	C1510586
Disease	carpal tunnel syndrome	ADAMTS14 KANK2	4.74e-03	89	34	2	EFO_0004143

Protein segments in the cluster

Peptide	Gene	Start	Entry
SWSISPTTPGGLPWG	ADAMTS14	1176	Q8WXS8
EPTAWLDSGTWGVPS	PTPN5	131	P54829
TWSPEAWGTPSTGTI	IL11RA	306	Q14626
PSASWALSAWEGPST	MAGEL2	961	Q9UJ55
GSPTSLGTWGSWIGP	PRKCSH	441	P14314
SPPSTLVWKGQSSWG	LMNB2	541	Q03252
WLPAGSTSGLLNSTW	FAM86C1P	106	Q9NVL1
SLLSPWGPWAGSGSI	PLXNB1	731	O43157
SVTSSWTSGAWSPPC	FAM214B	131	Q7L5A3
GTKSSPGWSWEAGPL	GGA2	446	Q9UJY4
CWVTGWGLISPSGTP	PRSS41	181	Q7RTY9
SPWTSPTWLKTNGAV	GBA	216	P04062
ATPAPPSWWDSSQSS	OPN4	21	Q9UHM6
PSDSSSWPKSGWPSA	ICE2	686	Q659A1
PLGSSLSPWWRSSLT	KDM2B	836	Q8NHM5
TWLSLQWSKPSGTPS	FNDC3A	481	Q9Y2H6
STSDFPSSPWDWIGL	INPP5K	351	Q9BT40
PVSTWGPSWAQLLDS	C20orf141	36	Q9NUB4
QGPPLLATSVTSWWS	ADGRG1	131	Q9Y653
SSLPRGPGSWWTSTE	KANK2	71	Q63ZY3
SPTSASKRWPGASVW	CPEB1	246	Q9BZB8
TLSQWSTPGSTPSRW	MENT	171	Q9BUN1
WLPSTPATSWGGLTS	PLIN4	1041	Q96Q06
LPSTSPGHWTQSTPW	HHLA1	246	C9JL84
PKPSSTWGASPLGWT	TNRC6C	1481	Q9HCJ0
GVWGPWAPSSLPTST	SYNE4	231	Q8N205
TSSASGQWSPTPEWV	HID1	671	Q8IV36
SPSATWLSPSSTPWM	SPATA31E1	51	Q6ZUB1
GGWTPWTSWSPCSTT	SEMA5A	596	Q13591
TGWLPTWCPTSISHL	ABHD5	21	Q8WTS1
SPSWSAWQLPSTGDE	TICRR	1806	Q7Z2Z1
GAWPSPLPSRSSGIW	MKRN3	81	Q13064
TESSPGWGSSGPWSL	ZFP36	26	P26651
GWGSSGPWSLSPSDS	ZFP36	31	P26651
CTSSQGPSSWTHWLP	AXL	311	P30530
AWGTDTPPATPRSSW	TET3	436	O43151
ILGTWTGPAWSPAQS	UBE2Z	191	Q9H832
PSGNSSPWWPLATGA	AVPR1A	11	P37288
ATWVTHSSWLPSGIP	XKR8	301	Q9H6D3
SAAPWGSSSILPISW	GLDC	801	P23378