Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionbenzodiazepine receptor binding

RIMBP3 RIMBP3C RIMBP3B

2.43e-0651263GO:0030156
GeneOntologyMolecularFunctionphosphorylase kinase activity

PHKA1 PHKA2

2.35e-0441262GO:0004689
GeneOntologyCellularComponentmicrotubule minus-end

CAMSAP3 SVIL ASPM

7.71e-0671283GO:0036449
GeneOntologyCellularComponentmicrotubule end

CAMSAP3 MISP SVIL ASPM

8.43e-05381284GO:1990752
GeneOntologyCellularComponentphosphorylase kinase complex

PHKA1 PHKA2

3.68e-0451282GO:0005964
MousePhenoabnormal CD4-positive, gamma-delta intraepithelial T cell morphology

BTNL8 BTNL3

4.77e-052972MP:0008357
MousePhenodecreased CD4-positive, gamma-delta intraepithelial T cell number

BTNL8 BTNL3

4.77e-052972MP:0008359
DomainNPIP

NPIPB15 NPIPB9 NPIPB8 NPIPB6

1.70e-06141234IPR009443
DomainHomeodomain-like

POU5F2 TLX3 RAX2 TLX1 TLX2 SIX6 ZZZ3 LPO PITX3 PAX7 CERS4

1.24e-0533212311IPR009057
Domain-

POU5F2 TLX3 RAX2 TLX1 TLX2 SIX6 ZZZ3 PITX3 PAX7 CERS4

1.81e-05283123101.10.10.60
DomainHomeobox

POU5F2 TLX3 RAX2 TLX1 TLX2 SIX6 PITX3 PAX7 CERS4

2.49e-052341239PF00046
DomainHOX

POU5F2 TLX3 RAX2 TLX1 TLX2 SIX6 PITX3 PAX7 CERS4

2.75e-052371239SM00389
DomainHOMEOBOX_2

POU5F2 TLX3 RAX2 TLX1 TLX2 SIX6 PITX3 PAX7 CERS4

2.94e-052391239PS50071
DomainHomeobox_dom

POU5F2 TLX3 RAX2 TLX1 TLX2 SIX6 PITX3 PAX7 CERS4

2.94e-052391239IPR001356
DomainNHL

NHLRC3 TENM3 TENM1

7.60e-05131233PS51125
DomainCCDC85

CCDC85A CCDC85B

1.29e-0431232IPR019359
DomainCCDC85

CCDC85A CCDC85B

1.29e-0431232PF10226
DomainGlyco_hydro_15/PHK

PHKA1 PHKA2

1.29e-0431232IPR011613
DomainPHK_A/B_su

PHKA1 PHKA2

1.29e-0431232IPR008734
DomainGlyco_hydro_15

PHKA1 PHKA2

1.29e-0431232PF00723
DomainHOMEOBOX_1

TLX3 RAX2 TLX1 TLX2 SIX6 PITX3 PAX7 CERS4

1.71e-042361238PS00027
DomainTox-GHH_dom

TENM3 TENM1

2.56e-0441232IPR028916
DomainTox-GHH

TENM3 TENM1

2.56e-0441232PF15636
DomainTen_N

TENM3 TENM1

2.56e-0441232IPR009471
DomainTen_N

TENM3 TENM1

2.56e-0441232PF06484
DomainTENEURIN_N

TENM3 TENM1

2.56e-0441232PS51361
DomainYD

TENM3 TENM1

4.25e-0451232IPR006530
DomainCAMSAP_CH

CAMSAP3 ASPM

8.84e-0471232PF11971
DomainCAMSAP_CH

CAMSAP3 ASPM

8.84e-0471232IPR022613
Domain6hp_glycosidase

PHKA1 PHKA2

1.17e-0381232IPR012341
Domain-

PHKA1 PHKA2

1.17e-03812321.50.10.10
DomainCH

CAMSAP3 SPTBN5 ASPM MACF1

1.17e-03701234PF00307
DomainCH

CAMSAP3 SPTBN5 ASPM MACF1

1.37e-03731234PS50021
DomainHomeobox_CS

TLX3 RAX2 TLX1 TLX2 PITX3 PAX7

1.46e-031861236IPR017970
DomainCH-domain

CAMSAP3 SPTBN5 ASPM MACF1

1.52e-03751234IPR001715
DomainSH3_9

PACSIN3 RIMBP3 RIMBP3C RIMBP3B

1.75e-03781234PF14604
DomainARM-type_fold

HEATR4 INTS1 FRYL NOP9 INSC NBEAL2 ASPM DAAM2

1.83e-033391238IPR016024
DomainARM-like

HEATR4 FRYL NOP9 INSC NBEAL2 ASPM DAAM2

2.09e-032701237IPR011989
Domain-

NHLRC3 TENM3 TENM1

2.14e-033912332.120.10.30
DomainIg-like_fold

PAPPA2 BTNL8 HLA-H RIMBP3 SEMA3A NPTN BTNL3 AGER ERMAP RIMBP3C RIMBP3B FCAMR

2.42e-0370612312IPR013783
DomainPRY

BTNL8 BTNL3 ERMAP

2.65e-03421233PF13765
Domain6-hairpin_glycosidase-like

PHKA1 PHKA2

3.20e-03131232IPR008928
DomainConA-like_dom

PAPPA2 PTX4 BTNL8 BTNL3 NBEAL2 ERMAP

3.31e-032191236IPR013320
Domain6-blade_b-propeller_TolB-like

NHLRC3 TENM3 TENM1

3.44e-03461233IPR011042
Domain-

HEATR4 FRYL NOP9 INSC ASPM DAAM2

3.53e-0322212361.25.10.10
DomainPRY

BTNL8 BTNL3 ERMAP

3.88e-03481233SM00589
DomainZnF_C3H1

MKRN3 RBM22 ZC3H7B

3.88e-03481233SM00356
DomainPRY

BTNL8 BTNL3 ERMAP

3.88e-03481233IPR006574
Domainzf-CCCH

MKRN3 RBM22 ZC3H7B

4.12e-03491233PF00642
DomainEF-hand_like

PLCH2 PLCD1

4.27e-03151232PF09279
DomainPI-PLC-Y

PLCH2 PLCD1

4.27e-03151232PF00387
DomainPLCYc

PLCH2 PLCD1

4.27e-03151232SM00149
DomainPLipase_C_Pinositol-sp_Y

PLCH2 PLCD1

4.27e-03151232IPR001711
DomainPIPLC_Y_DOMAIN

PLCH2 PLCD1

4.27e-03151232PS50008
DomainPI-PLC_fam

PLCH2 PLCD1

4.27e-03151232IPR001192
DomainPLC_EF-hand-like

PLCH2 PLCD1

4.27e-03151232IPR015359
Domain-

PAPPA2 BTNL8 RIMBP3 SEMA3A NPTN BTNL3 AGER ERMAP RIMBP3C RIMBP3B FCAMR

4.39e-03663123112.60.40.10
DomainOAR

PITX3 PAX7

4.86e-03161232PS50803
DomainOAR_dom

PITX3 PAX7

4.86e-03161232IPR003654
DomainRUN

DENND5B RUNDC3A

6.14e-03181232SM00593
DomainPI-PLC-X

PLCH2 PLCD1

6.14e-03181232PF00388
DomainPLCXc

PLCH2 PLCD1

6.14e-03181232SM00148
Pubmed

Integrative characterization of germ cell-specific genes from mouse spermatocyte UniGene library.

RIMBP3 RIMBP3C TDRD6 RIMBP3B IQCM

1.59e-0914135517662146
Pubmed

A new recurrent and specific cryptic translocation, t(5;14)(q35;q32), is associated with expression of the Hox11L2 gene in T acute lymphoblastic leukemia.

TLX3 TLX1 TLX2

5.72e-083135311587205
Pubmed

Development expression of Hox11 and specification of splenic cell fate.

TLX3 TLX1 TLX2

5.72e-08313537747804
Pubmed

The HOX11 gene encodes a DNA-binding nuclear transcription factor belonging to a distinct family of homeobox genes.

TLX3 TLX1 TLX2

2.28e-07413538099440
Pubmed

RIM-BP3 is a manchette-associated protein essential for spermiogenesis.

RIMBP3 RIMBP3C RIMBP3B

2.28e-074135319091768
Pubmed

Structure and evolution of RIM-BP genes: identification of a novel family member.

RIMBP3 RIMBP3C RIMBP3B

5.69e-075135317855024
Pubmed

Butyrophilin-like 1 encodes an enterocyte protein that selectively regulates functional interactions with T lymphocytes.

BTNL8 BTNL3

1.50e-052135221368163
Pubmed

X-linked liver glycogenosis type II (XLG II) is caused by mutations in PHKA2, the gene encoding the liver alpha subunit of phosphorylase kinase.

PHKA1 PHKA2

1.50e-05213528733133
Pubmed

Characterization and developmental expression of Tlx-1, the murine homolog of HOX11.

TLX1 TLX2

1.50e-05213527908826
Pubmed

The multiphosphorylation domain of the phosphorylase kinase alpha M and alpha L subunits is a hotspot of differential mRNA processing and of molecular evolution.

PHKA1 PHKA2

1.50e-05213528226841
Pubmed

A butyrophilin family member critically inhibits T cell activation.

BTNL8 BTNL3

1.50e-052135220944003
Pubmed

The ontogeny of Butyrophilin-like (Btnl) 1 and Btnl6 in murine small intestine.

BTNL8 BTNL3

1.50e-052135227528202
Pubmed

The CAMSAP3-ACF7 Complex Couples Noncentrosomal Microtubules with Actin Filaments to Coordinate Their Dynamics.

CAMSAP3 MACF1

1.50e-052135227693509
Pubmed

HOX11, a homeobox-containing T-cell oncogene on human chromosome 10q24.

TLX1 TLX2

1.50e-05213521681546
Pubmed

cDNA cloning of a liver isoform of the phosphorylase kinase alpha subunit and mapping of the gene to Xp22.2-p22.1, the region of human X-linked liver glycogenosis.

PHKA1 PHKA2

1.50e-05213521372435
Pubmed

Control of apico-basal epithelial polarity by the microtubule minus-end-binding protein CAMSAP3 and spectraplakin ACF7.

CAMSAP3 MACF1

1.50e-052135227802168
Pubmed

Uhrf1 governs the proliferation and differentiation of muscle satellite cells.

UHRF1 PAX7

1.50e-052135235243267
Pubmed

A novel phospholipase C, PLC(eta)2, is a neuron-specific isozyme.

PLCH2 PLCD1

1.50e-052135215899900
Pubmed

RAGE signaling deficiency in rhabdomyosarcoma cells causes upregulation of PAX7 and uncontrolled proliferation.

AGER PAX7

1.50e-052135224554430
Pubmed

Thymic adult T-cell acute lymphoblastic leukemia stratified in standard- and high-risk group by aberrant HOX11L2 expression: experience of the German multicenter ALL study group.

TLX3 TLX1

1.50e-052135218368072
Pubmed

Formation of brainstem (nor)adrenergic centers and first-order relay visceral sensory neurons is dependent on homeodomain protein Rnx/Tlx3.

TLX3 TLX1 TLX2

2.02e-0514135311581159
Pubmed

An integrated holo-enhancer unit defines tissue and gene specificity of the Fgf8 regulatory landscape.

FBXW4 TLX1 PITX3

2.02e-0514135323453598
Pubmed

Proper development of relay somatic sensory neurons and D2/D4 interneurons requires homeobox genes Rnx/Tlx-3 and Tlx-1.

TLX3 TLX1 SEMA3A

3.74e-0517135312023301
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

CDK12 KIF21A HECTD4 SPIRE1 SFI1 SMG7 NBEAL2 PLCH2 TTLL4 ZC3H7B

4.39e-055291351014621295
Pubmed

Reverse engineering of TLX oncogenic transcriptional networks identifies RUNX1 as tumor suppressor in T-ALL.

TLX3 TLX1

4.48e-053135222366949
Pubmed

Clinical significance of HOX11L2 expression linked to t(5;14)(q35;q32), of HOX11 expression, and of SIL-TAL fusion in childhood T-cell malignancies: results of EORTC studies 58881 and 58951.

TLX3 TLX1

4.48e-053135214504110
Pubmed

Glucoamylase-like domains in the alpha- and beta-subunits of phosphorylase kinase.

PHKA1 PHKA2

4.48e-053135212876330
Pubmed

Assessment of F-MuLV-induced tumorigenesis reveals new candidate tumor genes including Pecam1, St7, and Prim2.

ST7 PRIM2

4.48e-053135216307020
Pubmed

Ancestry and frequency of genetic variants in the general population are confounders in the characterization of germline variants linked to cancer.

BTNL8 BTNL3

4.48e-053135232375678
Pubmed

TLX homeodomain oncogenes mediate T cell maturation arrest in T-ALL via interaction with ETS1 and suppression of TCRα gene expression.

TLX3 TLX1

4.48e-053135222516263
Pubmed

Autocrine Semaphorin3A stimulates eukaryotic initiation factor 4E-dependent RhoA translation in breast tumor cells.

SEMA3A EIF4E

4.48e-053135220655307
Pubmed

Defective RAGE activity in embryonal rhabdomyosarcoma cells results in high PAX7 levels that sustain migration and invasiveness.

AGER PAX7

4.48e-053135225123133
Pubmed

HMGB1-RAGE regulates muscle satellite cell homeostasis through p38-MAPK- and myogenin-dependent repression of Pax7 transcription.

AGER PAX7

8.93e-054135222328527
Pubmed

Mouse ten-m/Odz is a new family of dimeric type II transmembrane proteins expressed in many tissues.

TENM3 TENM1

8.93e-054135210225957
Pubmed

Butyrophilin-like proteins display combinatorial diversity in selecting and maintaining signature intraepithelial γδ T cell compartments.

BTNL8 BTNL3

8.93e-054135232724083
Pubmed

Isolation of cDNA clones for the catalytic gamma subunit of mouse muscle phosphorylase kinase: expression of mRNA in normal and mutant Phk mice.

PHKA1 PHKA2

8.93e-05413523472241
Pubmed

Epithelia Use Butyrophilin-like Molecules to Shape Organ-Specific γδ T Cell Compartments.

BTNL8 BTNL3

8.93e-054135227641500
Pubmed

Inhibition of SUV39H1 methyltransferase activity by DBC1.

BRINP1 SUV39H1

8.93e-054135219218236
Pubmed

The SRA protein UHRF1 promotes epigenetic crosstalks and is involved in prostate cancer progression.

SUV39H1 UHRF1

8.93e-054135222330138
Pubmed

All four members of the Ten-m/Odz family of transmembrane proteins form dimers.

TENM3 TENM1

8.93e-054135212000766
Pubmed

Cleavage of phosphorylase kinase and calcium-free calmodulin by HIV-1 protease.

PHKA1 PHKA2

8.93e-05413521872871
Pubmed

Transcriptional activation by TLX1/HOX11 involves Gro/TLE corepressors.

TLX3 TLX1

8.93e-054135219250647
Pubmed

Phosphorylase Kinase Deficiency

PHKA1 PHKA2

8.93e-054135221634085
Pubmed

Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray.

VIPR1 NIPSNAP1 HLA-H ATF6B TENM3 SVIL EIF4E CSPP1

1.06e-04371135815747579
Pubmed

Location of phosphorylase kinase (Phk) in the mouse X chromosome.

PHKA1 PHKA2

1.48e-04513524726088
Pubmed

Heteromeric interactions regulate butyrophilin (BTN) and BTN-like molecules governing γδ T cell biology.

BTNL8 BTNL3

1.48e-045135229339503
Pubmed

Neurogenic decisions require a cell cycle independent function of the CDC25B phosphatase.

TLX3 PAX7

1.48e-045135229969095
Pubmed

Genetic mapping of two mouse homeobox genes Tlx-1 and Tlx-2 to murine chromosomes 19 and 6.

TLX1 TLX2

1.48e-04513527698766
Pubmed

The proline-rich homeodomain protein, PRH, is a tissue-specific inhibitor of eIF4E-dependent cyclin D1 mRNA transport and growth.

TLX1 EIF4E

1.48e-045135212554669
Pubmed

Cig30 and Pitx3 genes are arranged in a partially overlapping tail-to-tail array resulting in complementary transcripts.

TLX1 PITX3

1.48e-045135210473596
Pubmed

Role of the E3 ubiquitin-ligase Hakai in intestinal inflammation and cancer bowel disease.

NARS1 FASN RPL13

1.56e-0427135336266428
Pubmed

BTL-II: a polymorphic locus with homology to the butyrophilin gene family, located at the border of the major histocompatibility complex class II and class III regions in human and mouse.

BTNL8 BTNL3

2.22e-046135210803852
Pubmed

Improving GENCODE reference gene annotation using a high-stringency proteogenomics workflow.

CENPVL2 CENPVL1

2.22e-046135227250503
Pubmed

Sequential expression and redundancy of Pitx2 and Pitx3 genes during muscle development.

PITX3 PAX7

2.22e-046135217540357
Pubmed

A census of human transcription factors: function, expression and evolution.

SOX12 KLF11 ZNF268 TLX3 RAX2 ATF6B TLX1 TLX2 SIX6 ZZZ3 PITX3 PAX7

2.29e-049081351219274049
Pubmed

Embryonic forebrain transcriptome of mice with polyalanine expansion mutations in the ARX homeobox gene.

SIX6 ASPM TENM1

2.37e-0431135327798109
Pubmed

Tlx1/3 and Ptf1a control the expression of distinct sets of transmitter and peptide receptor genes in the developing dorsal spinal cord.

VIPR1 TLX3 SSTR4 TLX1

2.87e-0481135422723691
Pubmed

DIPA-family coiled-coils bind conserved isoform-specific head domain of p120-catenin family: potential roles in hydrocephalus and heterotopia.

CCDC85A CCDC85B

3.10e-047135225009281
Pubmed

Redox regulation by Pitx2 and Pitx3 is critical for fetal myogenesis.

PITX3 PAX7

3.10e-047135224871946
Pubmed

The murine Ten-m/Odz genes show distinct but overlapping expression patterns during development and in adult brain.

TENM3 TENM1

3.10e-047135212915301
Pubmed

Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.

DENND5B ST7 INTS1 PACSIN3 MRPS30 NPTN SMG7 CROCC2 SVIL RIMBP3C

3.74e-046891351036543142
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

CDK12 INTS1 HECTD4 SPIRE1 FRYL SFI1 FASN IL17RE NBEAL2 TTLL4 SURF6 BANP ZC3H7B

3.84e-0411051351335748872
Pubmed

Cognate antigen engagement on parenchymal cells stimulates CD8+ T cell proliferation in situ.

HLA-H IL2RA

4.12e-048135228401883
Pubmed

Mapping homologs of Drosophila odd Oz (odz): Doc4/Odz4 to mouse chromosome 7, Odz1 to mouse chromosome 11; and ODZ3 to human chromosome Xq25.

TENM3 TENM1

4.12e-048135210331952
Pubmed

Risk alleles for multiple sclerosis identified by a genomewide study.

BRINP1 IL2RA

4.12e-048135217660530
Pubmed

Identification of genes within the Krd deletion on mouse chromosome 19.

TLX1 PITX3

4.12e-048135210087301
Pubmed

Genome-wide association study of d-amphetamine response in healthy volunteers identifies putative associations, including cadherin 13 (CDH13).

TENM3 TENM1 PAX7

4.37e-0438135322952603
Pubmed

Proximity Mapping of CCP6 Reveals Its Association with Centrosome Organization and Cilium Assembly.

SMG7 DDRGK1 CSPP1

4.37e-0438135336674791
Pubmed

KAP1 facilitates reinstatement of heterochromatin after DNA replication.

DHX16 CDK12 NARS1 MRPS30 TMX1 FASN NOP9 PRIM2 SUV39H1 ZC3H7B

4.42e-047041351029955894
Pubmed

Inflammation-dependent overexpression of c-Myc enhances CRL4DCAF4 E3 ligase activity and promotes ubiquitination of ST7 in colitis-associated cancer.

LST1 NRBP1 ST7 KIF21A FBXW4 PHKA2

5.21e-04257135630945288
Pubmed

Genome-wide association study identifies five loci associated with lung function.

AGER DAAM2

5.29e-049135220010834
Pubmed

A novel Creb family gene telomeric of HLA-DRA in the HLA complex.

HLA-H ATF6B

5.29e-04913528586413
Pubmed

The role of Pitx2 and Pitx3 in muscle stem cells gives new insights into P38α MAP kinase and redox regulation of muscle regeneration.

PITX3 PAX7

5.29e-049135230106373
Pubmed

Elevation of hsa-miR-7-5p level mediated by CtBP1-p300-AP1 complex targets ATXN1 to trigger NF-κB-dependent inflammation response.

NARS1 NOL9 SURF6 UHRF1 CERS4

5.61e-04171135536629882
Pubmed

Hox cofactors in vertebrate development.

TLX3 TLX1

6.59e-0410135216515781
Pubmed

Cartography of teneurin and latrophilin expression reveals spatiotemporal axis heterogeneity in the mouse hippocampus during development.

TENM3 TENM1

6.59e-0410135238713721
Pubmed

HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.

MKRN3 NOL9 RAB11FIP1 TMX1 MISP FASN BTNL3 SURF6 TMEM109 RPL13

7.49e-047541351035906200
Pubmed

Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

DHX16 ZNF862 SFI1 NBEAL2

7.66e-0410513549628581
Pubmed

Tlx3 and Tlx1 are post-mitotic selector genes determining glutamatergic over GABAergic cell fates.

TLX3 TLX1

8.04e-0411135215064766
Pubmed

Ermap, a gene coding for a novel erythroid specific adhesion/receptor membrane protein.

ERMAP MACF1

8.04e-0411135210721728
Pubmed

Rab23 is an essential negative regulator of the mouse Sonic hedgehog signalling pathway.

PRIM2 PAX7

9.62e-0412135211449277
Pubmed

A mouse chromosome 19 genetic map including the Lvis1 viral insertion site.

TLX1 PITX3

9.62e-0412135210051411
Pubmed

Canonical BMP7 activity is required for the generation of discrete neuronal populations in the dorsal spinal cord.

TLX3 PAX7

1.13e-0313135222159578
Pubmed

Risk alleles for multiple sclerosis in multiplex families.

BRINP1 IL2RA

1.13e-0313135219506219
Pubmed

The intracellular domain of teneurin-1 induces the activity of microphthalmia-associated transcription factor (MITF) by binding to transcriptional repressor HINT1.

TENM1 MACF1

1.13e-0313135225648896
Pubmed

Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.

KLF11 COX18 ATF6B AGER MMP8

1.16e-03201135523535732
Pubmed

Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse.

LST1 ATF6B AGER

1.29e-0355135314656967
Pubmed

Replication of CD58 and CLEC16A as genome-wide significant risk genes for multiple sclerosis.

BRINP1 IL2RA

1.32e-0314135219834503
Pubmed

Mapping of a liver phosphorylase kinase alpha-subunit gene on the mouse X chromosome.

PHKA1 PHKA2

1.32e-031413528432533
Pubmed

Impact of cytosine methylation on DNA binding specificities of human transcription factors.

SOX12 KLF11 TLX3 ATF6B TLX2 SIX6 PITX3 PAX7

1.33e-03544135828473536
Pubmed

Homologs of genes expressed in Caenorhabditis elegans GABAergic neurons are also found in the developing mouse forebrain.

SUV39H1 PITX3 PAX7

1.44e-0357135321122108
Pubmed

Variant of TYR and autoimmunity susceptibility loci in generalized vitiligo.

C1QTNF6 IL2RA

1.52e-0315135220410501
Pubmed

Tlx1 and Tlx3 coordinate specification of dorsal horn pain-modulatory peptidergic neurons.

TLX3 TLX1

1.52e-0315135218400903
Pubmed

Positive autofeedback regulation of Ptf1a transcription generates the levels of PTF1A required to generate itch circuit neurons.

TLX3 TLX1

1.52e-0315135232241803
Pubmed

Nkx2.9 Contributes to Mid-Hindbrain Patterning by Regulation of mdDA Neuronal Cell-Fate and Repression of a Hindbrain-Specific Cell-Fate.

PITX3 PAX7

1.52e-0315135234884468
Pubmed

Missing self-recognition of Ocil/Clr-b by inhibitory NKR-P1 natural killer cell receptors.

HLA-H IL2RA

1.52e-0315135214990792
Pubmed

Ptf1a, Lbx1 and Pax2 coordinate glycinergic and peptidergic transmitter phenotypes in dorsal spinal inhibitory neurons.

TLX3 TLX1

1.52e-0315135218634777
Pubmed

Klf5 regulates muscle differentiation by directly targeting muscle-specific genes in cooperation with MyoD in mice.

KLF11 PAX7

1.52e-0315135227743478
Pubmed

dILA neurons in the dorsal spinal cord are the product of terminal and non-terminal asymmetric progenitor cell divisions, and require Mash1 for their development.

TLX3 PAX7

1.52e-0315135216690754
Pubmed

Ascl1 and Gsh1/2 control inhibitory and excitatory cell fate in spinal sensory interneurons.

TLX3 PAX7

1.52e-0315135216715081
InteractionSMARCD1 interactions

MKRN3 TLX3 PACSIN3 TLX1 FASN INSC SUV39H1 PLCD1 PAX7 RPL13 CCDC85B

1.44e-0534912811int:SMARCD1
InteractionPRR12 interactions

TLX3 TLX1 TLX2 FASN SMG7 PAX7

2.07e-05881286int:PRR12
InteractionTLE4 interactions

TLX3 TLX1 TLX2 SIX6 SMG7 PAX7

2.66e-05921286int:TLE4
InteractionMNX1 interactions

TLX3 TLX1 TLX2 PAX7

2.82e-05281284int:MNX1
GeneFamilyButyrophilins|V-set domain containing|C2-set domain containing

BTNL8 BTNL3 ERMAP

3.93e-0515823458
ToppCellLung_Parenchyma-Severe-Epithelial-Epithelial-AT1-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

RAB11FIP1 CCDC85A MISP IL17RE AGER NBEAL2 SNX22

2.56e-061991357f8846446ebbc4948cdc69640782db1358bbdc486
ToppCellParenchyma_COVID-19-Epithelial-TX-AT1|Parenchyma_COVID-19 / Sample group, Lineage and Cell type

RAB11FIP1 CCDC85A MISP IL17RE AGER NBEAL2 SNX22

2.56e-061991357fe9f5bc317be0c35bd96311bf0b3c7b91d98acc5
ToppCellLung_Parenchyma-Severe-Epithelial-Epithelial-AT1|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

RAB11FIP1 CCDC85A MISP IL17RE AGER NBEAL2 SNX22

2.56e-0619913573e35ee426ef06f9af568c37349b62dd1ee9b97ea
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Degenerative_Fibroblast-Degenerative_Fibroblast_104|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

NPIPB9 HEATR4 CYP46A1 FASN PRELP TDRD6

1.17e-051661356c11dcf9705b85ac3da6ae86358f5ffd64ae8327e
ToppCellP15-Epithelial-airway_epithelial_cell-ciliated_cell_of_airway|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

SOX12 SFI1 AGER NBEAL2 TTLL4 DAAM2

1.21e-0516713565c3d0763f73628c71c71f9883556bb4f1639f3cc
ToppCellPND28-Immune-Immune_Myeloid-Monocytic-Macrophage-iMON-iMON_prolif|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LST1 SPIRE1 FRAT2 SMG7 SUV39H1 MMP8

1.25e-05168135627cdf5cfa1d906868cfd60fdfab3cd51f3b3602f
ToppCell343B-Lymphocytic-NK_cells-Proliferating_NK_cell|NK_cells / Donor, Lineage, Cell class and subclass (all cells)

ZNF862 CYP46A1 SUV39H1 ASPM UHRF1 DAAM2

1.97e-051821356b1e66ccd5f33b4801f1cafddf97f5fc0c6dba8d1
ToppCellCOVID-19-lung-AT1|COVID-19 / Disease (COVID-19 only), tissue and cell type

RAB11FIP1 CCDC85A IL17RE AGER NBEAL2 SNX22

2.03e-0518313567b1a385ed54f93bfe85bf0c162e42d05d516b45c
ToppCell343B-Epithelial_cells-Epithelial-I_(AT1)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

RAB11FIP1 IL17RE AGER NBEAL2 PLCD1 SNX22

2.09e-051841356c7073d1b2c4fdb154d87678b92a0629c02116972
ToppCell343B-Epithelial_cells-Epithelial-I_(AT1)|343B / Donor, Lineage, Cell class and subclass (all cells)

RAB11FIP1 MISP IL17RE AGER NBEAL2 SNX22

2.09e-051841356cb15d6bae52c5ec251c2235859dc7e65f630ae23
ToppCell343B-Epithelial_cells-Epithelial-I_(AT1)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

RAB11FIP1 IL17RE AGER NBEAL2 PLCD1 SNX22

2.09e-0518413561ed558a88215b248431c524ea16f13d9022ae98c
ToppCell343B-Epithelial_cells-Epithelial-I_(AT1)-|343B / Donor, Lineage, Cell class and subclass (all cells)

RAB11FIP1 MISP IL17RE AGER NBEAL2 SNX22

2.09e-051841356bde4eaabd3e9bdaed23867d23a919b9d84b52d4b
ToppCellAT1_cells-SSc-ILD_01|World / lung cells shred on cell class, cell subclass, sample id

RAB11FIP1 CCDC85A MISP AGER NBEAL2 SNX22

2.29e-051871356f1dda349335e08dbfc8395d373924037f5ad2fd6
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_1-D231|Adult / Lineage, Cell type, age group and donor

RAB11FIP1 CCDC85A IL17RE AGER NBEAL2 SNX22

2.43e-0518913565a04cb25f8f0447b2cecdb6c3695029281aca26d
ToppCell3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KIF21A ATP10B CRACR2B SEMA3A MISP PAX7

2.51e-0519013566ea9fa08bd97bedcb21d3654467e7f8dd74c8fd0
ToppCelldroplet-Lung-18m-Hematologic-myeloid-classical_monocyte-classical_monocyte_l15|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SOX12 SPIRE1 FASN PLCD1 CSPP1

2.55e-05114135584318a25a701331ccd5e68221239c543b9c0cc54
ToppCellP07-Epithelial-alveolar_epithelial_cell-type_I_pneumocyte|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

RAB11FIP1 SEMA3A IL17RE AGER DAAM2 KLC3

2.58e-0519113560f360766490bef3495c42f6421b22a988cfc68fb
ToppCelldroplet-Mammary_Gland-nan-21m-Epithelial-luminal_epithelial_cell_of_mammary_gland|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PACSIN3 ATP10B CRACR2B RAB11FIP1 IL17RE KLC3

2.74e-05193135622ebc3f586eb0aabc5785e468c88d7416c624ff4
ToppCellAT1_cells|World / lung cells shred on cell class, cell subclass, sample id

RAB11FIP1 CCDC85A MISP AGER NBEAL2 SNX22

2.90e-051951356792d6a49b0a875a00569071183d195287a9925c5
ToppCellAT1_cells-Donor_06|World / lung cells shred on cell class, cell subclass, sample id

RAB11FIP1 CCDC85A MISP AGER NBEAL2 SNX22

3.07e-05197135680d81be244c94c435accb643449b4ce6a3462c7f
ToppCellEpithelial_cells-AT1-AT2_cells|Epithelial_cells / lung cells shred on cell class, cell subclass, sample id

RAB11FIP1 CCDC85A MISP AGER NBEAL2 SNX22

3.16e-051981356fbc46b20bcd44f2083170aacbc6f5dd00fba685c
ToppCell(7)_Epithelial_cells-(7)_Epithelial-I_(AT1)|(7)_Epithelial_cells / Lung cell shreds - cell class (v4) and cell subclass (v4)

RAB11FIP1 CCDC85A MISP IL17RE AGER NBEAL2

3.25e-0519913565a002d49a8b84c158f7b4d7a3e78e6a937757bb7
ToppCellLPS_anti-TNF-Epithelial_alveolar-AT_1-Differentiating_AT1|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

MISP IL17RE AGER NBEAL2 FCAMR KLC3

3.25e-051991356d43c605a4ff221cf78d91678c15d2ad20f831c7f
ToppCellLPS_only-Epithelial_alveolar-AT_1-Differentiating_AT1|LPS_only / Treatment groups by lineage, cell group, cell type

KIF21A FAM83E PHKA2 MISP IL17RE AGER

3.34e-0520013562dadf317a42a7e27cc1fac74f91b806c93a57108
ToppCellParenchymal-10x3prime_v2-Epithelial-Epi_alveolar-AT1|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

RAB11FIP1 MISP IL17RE AGER NBEAL2 SNX22

3.34e-0520013563d51aebf626dd4656ab4aac8a20d761b8062c42d
ToppCellBiopsy_Other_PF-Epithelial-AT1|Biopsy_Other_PF / Sample group, Lineage and Cell type

RAB11FIP1 MISP IL17RE AGER SNX22 KLC3

3.34e-052001356b746dcc94814bcbca63c71e6451a9c5f084bcfaf
DiseaseGlycogen phosphorylase kinase deficiency

PHKA1 PHKA2

1.05e-0441242cv:C0268147
Diseaseglycogen storage disease (is_implicated_in)

PHKA1 PHKA2

6.19e-0491242DOID:2747 (is_implicated_in)
Diseasetonsillectomy risk measurement

LST1 NIPSNAP1 HECTD4 NPIPB8 IL2RA CSPP1

8.29e-042601246EFO_0007924
Diseaseglucose-dependent insulinotropic peptide measurement, glucose tolerance test

PAPPA2 BTNL3

1.54e-03141242EFO_0004307, EFO_0008464
DiseaseGlycogen storage disease

PHKA1 PHKA2

2.29e-03171242cv:C0017919
Diseaseproprotein convertase subtilisin/kexin type 7 measurement

CEP164 RNF214

2.29e-03171242EFO_0008270
DiseaseMuscle hypotonia

INTS1 PAX7

2.29e-03171242C0026827
Diseaseneuroticism measurement, cognitive function measurement

MYO1H NIPSNAP1 BRINP1 CCDC85A RUNDC3A ZZZ3 TENM3 UHRF1

2.75e-035661248EFO_0007660, EFO_0008354
Diseaseautoimmune thyroid disease, systemic lupus erythematosus, type 1 diabetes mellitus, ankylosing spondylitis, psoriasis, common variable immunodeficiency, celiac disease, ulcerative colitis, Crohn's disease, autoimmune disease, juvenile idiopathic arthritis

TENM3 NPIPB6 IL2RA

3.23e-03701243EFO_0000384, EFO_0000676, EFO_0000729, EFO_0001060, EFO_0002609, EFO_0003898, EFO_0005140, EFO_0006812, MONDO_0005147, MONDO_0007915, MONDO_0015517
DiseaseAnophthalmia-microphthalmia syndrome

SIX6 PITX3

3.49e-03211242cv:C5680330

Protein segments in the cluster

PeptideGeneStartEntry
RTAWRRKQRGQSLAV

BANP

316

Q8N9N5
TGKITRENRSETWRR

ERICH3

241

Q5RHP9
WRRKHGQAELRDARK

BTNL3

271

Q6UXE8
ATRVNRRKSALALRW

AKAP2

831

Q9Y2D5
RWLGVRDQTRRQVKP

CERS4

66

Q9HA82
ELWSKKRRRQRQSGV

CDK12

1041

Q9NYV4
AVRANQLGWSKRDAR

COX18

131

Q8N8Q8
SERQRGRRAARQWQL

CCDC85B

86

Q15834
ARWKVRNTAIERRDL

BRINP1

76

O60477
WRRKHGQAELRDARK

BTNL8

271

Q6UX41
LGAQRERWETFRKLR

CENPVL1

96

A0A0U1RR11
QRRWEEARLGAASLK

DHX16

326

O60231
QRRAEEARRRKQWQE

CAMSAP3

911

Q9P1Y5
GSRLQAQRRAQRVAW

DDRGK1

71

Q96HY6
RGWKVRKQIRREHQA

ASPM

1886

Q8IZT6
KRNLEIQSWRSRQRP

ATP10B

1341

O94823
NVQRELRRGGRRNWT

ALPK1

526

Q96QP1
RVTRVARGNKWLNCR

MMP8

451

P22894
ILWQRRQRRGEERKA

AGER

361

Q15109
QNRRAKWRRQERLES

RAX2

76

Q96IS3
RRLNVKWGRSQAARG

RBM22

296

Q9NW64
RRVKLQLWDTSGQGR

RAB40B

61

Q12829
NWREILDSKRGAAQR

NT5C

186

Q8TCD5
LRSKWEAQRSRELRQ

RIMBP3B

76

A6NNM3
LRSKWEAQRSRELRQ

RIMBP3C

76

A6NJZ7
RIRAKHLAANWNRIR

IQCH

431

Q86VS3
RRGLWRTRQILNLAE

IQCM

341

A0A1B0GVH7
ITKRKWEAARRAEQR

HLA-H

166

P01893
SNRRARWRKQAGANQ

PAX7

266

P23759
RERWQRQRKVLAAGS

DAAM2

1001

Q86T65
RERWAVIQGQAVRKS

MISP

141

Q8IVT2
RRLRWRLLQAQASGV

NOL9

46

Q5SY16
WEQQQGAVAKRRRAL

NOP9

616

Q86U38
RIWQGRDQRTPQKRR

INTS1

1706

Q8N201
SKDSRQGQWQRRRRL

PHKA1

1046

P46020
GRWLITLNKQQRRSD

EIF4E

111

P06730
SWGRLGARQRRQSRL

IL17RE

636

Q8NFR9
RAIGWQDRARKALAS

KDM5D

1271

Q9BY66
RNGQVWEESLKRLRQ

LPO

86

P22079
SARERRRNKWKGLDI

CSPP1

1126

Q1MSJ5
VSWKRPQLSQRRTRE

FRYL

2346

O94915
VQQRAWRSNRSRQKG

NPIPB8

121

E9PQR5
LQQSGKWRRASRERR

POU5F2

206

Q8N7G0
QSRWEKVVQRSIERG

MACF1

2656

O94854
RSQARRLAQENVWLR

KLC3

106

Q6P597
RAWRSNRSRQKGLRS

NPIPB7

106

O75200
QTRWRRGNTRKQALV

HECTD4

1186

Q9Y4D8
RKAREVWRRNARAKA

H1-7

166

Q75WM6
RAWRSNRSRQKGLRS

NPIPB15

106

A6NHN6
RWEKVVQRSIERGRS

MACF1

6531

Q9UPN3
CGRWQKRREEVNQRN

NRBP1

61

Q9UHY1
WARKRLNIRVISGQQ

PLCD1

626

P51178
GKRNRIRSSLPWRQN

PPM1E

711

Q8WY54
RKWRKLRLAGDQRNA

PRIM2

6

P49643
ETQRRGWAKSRQRRQ

PAPPA2

186

Q9BXP8
RQRRQVWKRRAEDGQ

PAPPA2

196

Q9BXP8
ATPGRRLWRQRSVNK

BTBD18

291

B2RXH4
QRKLWRRRTSQEAER

FCAMR

471

Q8WWV6
GDRVWVRLFKRQREN

C1QTNF6

241

Q9BXI9
LGAQRERWETFRKLR

CENPVL2

96

P0DPI3
SIRFLRQVGRDWVQR

CYP46A1

246

Q9Y6A2
RLQGELELRRWAQRQ

CROCC2

201

H7BZ55
NQRLLTALRERKWGV

FUT10

361

Q6P4F1
LGKQRAVRTLWARLQ

CRACR2B

151

Q8N4Y2
NERTARWIQSKRPRR

HEATR4

211

Q86WZ0
NRWVSRSATAQRRKE

DENND5B

671

Q6ZUT9
RQKGKRVSREWQRLG

CCDC85A

116

Q96PX6
LSGLTWQRRQRKSRR

IL2RA

256

P01589
RVKVSQNWRLGRCRE

FBXW4

96

P57775
RRIGQKLAQDRWARV

INSC

136

Q1MX18
SWGQRSQKGDLLRIR

KLF11

56

O14901
EREKQRALEQGRRAW

CCDC177

381

Q9NQR7
RVRRSALNKLRVGWA

FAM240C

46

A0A1B0GVR7
AKQVRRWRRQGVQVQ

FASN

1926

P49327
VQQRAWRSNRSRQKG

NPIPB6

121

E9PJ23
LTEARVRVWFKNRRA

PITX3

101

O75364
RERKIRNRAVANTWT

KIF28P

351

B7ZC32
RAWRSNRSRQKGLRS

NPIPB9

121

F8W1W9
RVATWFNQPARKIRR

RPL13

21

P26373
RRLQQRRWTQAGARA

FRAT2

156

O75474
QWLRRRRLDGAINRV

PHKA2

1066

P46019
AWVRKLQRRGRKVDT

PTX4

106

Q96A99
KLQGQDSERVRAWQR

PACSIN3

101

Q9UKS6
RRVKRLERSWAQGSS

LST1

36

O00453
QSREETRNAAWRKRG

NIPSNAP1

241

Q9BPW8
LKRAAANSGWRRARL

ERMAP

221

Q96PL5
ENISTARAKGRAWIR

RUNDC3A

116

Q59EK9
KAARLRRIERWQATV

MRPS30

56

Q9NP92
TWRQRLGQVRVSRAL

SFI1

226

A8K8P3
RQLLRGALRRWKENT

SFI1

681

A8K8P3
LRDLHRDQGRRKTQW

RAB11FIP1

111

Q6WKZ4
KRTVNRQWSRALISG

TDRD6

826

O60522
KSGEEDWRNRLSRRQ

SVIL

1136

O95425
QRVKVFGWVHRLRRQ

NARS1

126

O43776
RWRRQVSGTVREKFV

FAM83E

226

Q2M2I3
RRESVALKGRTRSWQ

NBPF5P

331

Q86XG9
LRSKWEAQRSRELRQ

RIMBP3

76

Q9UFD9
QQSLLRRWGEVTGRR

FBXL18

661

Q96ME1
SGQRRQWERAQSRRA

NBEAL2

1751

Q6ZNJ1
QRRIRQQRLISIGKW

SMG7

451

Q92540
VALRAGWQQRRRSEK

SSTR4

241

P31391
GWQQRRRSEKKITRL

SSTR4

246

P31391
QVGNWFKNRRQRDRA

SIX6

171

O95475
RQRAVAQAWTKEQRR

TENM1

2651

Q9UKZ4
TGLRWINLDNNRIRK

PRELP

126

P51888
AQRQRRWEKRTAGVV

SURF6

301

O75683
WKRDRKQRRQRPGHT

SEMA3A

726

Q14563
QKAWRERNPQARISA

ST7

191

Q9NRC1
RALRRWEQELNAKRS

SUV39H1

126

O43463
WTRLQGRSEQRRRQL

SPTBN5

1296

Q9NRC6
GIIEANRRWLERVKN

CEP164

1411

Q9UPV0
LSGWVQRHQRGRRKI

ATF6B

516

Q99941
VRSKQEWETRLNGVR

RNF214

391

Q8ND24
LNGEVQAELRRKWRR

VIPR1

391

P32241
QERNSSWDRIRKLQG

ZNF268

16

Q14587
RWRSARQFENRIVKS

MKRN3

346

Q13064
RVWVADRGNKRIQVF

NHLRC3

226

Q5JS37
RTVRIWKARNLQDGQ

KIF21A

1646

Q7Z4S6
HNAEISKRLGRRWQL

SOX12

66

O15370
DSLARRQRTRDQWLK

PLCH2

161

O75038
RVRSAAQIRVWRDGA

SPIRE1

81

Q08AE8
RQLWDGARKRRVTVN

NPTN

76

Q9Y639
RRWEEEGFRQISLNK

UAP1L1

91

Q3KQV9
QRALARAWAREQQRV

TENM3

2626

Q9P273
WRTRGLEQRRQGLEA

SNX22

71

Q96L94
NRRTKWRRQTAEERE

TLX3

216

O43711
LRWRQRRAAKGARSV

TMEM109

226

Q9BVC6
LKDLNAVRWVASRRR

ZNF862

781

O60290
NRRTKWRRQTAEERE

TLX1

251

P31314
SRDVRARARTIIKWQ

UHRF1

201

Q96T88
IRRRIKWLQDGSQSL

VWA3B

486

Q502W6
FQIGRKDRLWRNLSR

TTLL4

666

Q14679
GRRSNVRVITDENWR

TMX1

26

Q9H3N1
ESRRWQKIADELGNR

ZZZ3

676

Q8IYH5
LEAWENGERSRKRRA

TNFSF13

91

O75888
RFRWSGRNNREKIGV

USP44

576

Q9H0E7
QNRRTKWRRQTAEER

TLX2

206

O43763
GRLRSSEDQTWKRIR

ZC3H7B

456

Q9UGR2
TFERINRKDLWERGQ

NLRP12

76

P59046
ALARKAIQRRKWAVR

MYO1H

741

Q8N1T3