Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	transition metal ion binding	LARGE2 CYP4Z2P EPRS1 CYP4Z1 TRIM26 UBR4 ZNF75D ZFHX3 TRIP12 CXXC1 LARGE1	2.85e-04	1189	54	11	GO:0046914
GeneOntologyMolecularFunction	UDP-xylosyltransferase activity	LARGE2 LARGE1	3.89e-04	11	54	2	GO:0035252
GeneOntologyMolecularFunction	xylosyltransferase activity	LARGE2 LARGE1	3.89e-04	11	54	2	GO:0042285
Domain	Ribosomal_L10e_CS	RPL10L RPL10	7.90e-06	2	53	2	IPR018255
Domain	Ribosomal_L10e	RPL10L RPL10	7.90e-06	2	53	2	IPR001197
Domain	RIBOSOMAL_L10E	RPL10L RPL10	7.90e-06	2	53	2	PS01257
Domain	Ribosomal_L10e/L16	RPL10L RPL10	2.37e-05	3	53	2	IPR016180
Domain	-	RPL10L RPL10	2.37e-05	3	53	2	3.90.1170.10
Domain	Ribosomal_L16	RPL10L RPL10	2.37e-05	3	53	2	PF00252
Domain	VWA_2	INTS6L INTS6	7.86e-05	5	53	2	PF13519
Domain	INT_SG_DDX_CT_C	INTS6L INTS6	2.19e-04	8	53	2	PF15300
Domain	INT_SG_DDX_CT_C	INTS6L INTS6	2.19e-04	8	53	2	IPR029307
Domain	Glyco_transf_8	LARGE2 LARGE1	3.50e-04	10	53	2	PF01501
Domain	Glyco_trans_8	LARGE2 LARGE1	3.50e-04	10	53	2	IPR002495
Domain	-	LARGE2 GALNT5 LARGE1	1.57e-03	81	53	3	3.90.550.10
Domain	Nucleotide-diphossugar_trans	LARGE2 GALNT5 LARGE1	2.00e-03	88	53	3	IPR029044
Domain	FERM_M	FRMD4A MYO15A	7.55e-03	46	53	2	PF00373
Domain	FERM_central	FRMD4A MYO15A	8.53e-03	49	53	2	IPR019748
Domain	FERM_domain	FRMD4A MYO15A	8.53e-03	49	53	2	IPR000299
Domain	FERM_1	FRMD4A MYO15A	8.87e-03	50	53	2	PS00660
Pathway	KEGG_MEDICUS_REFERENCE_MANNOSE_TYPE_O_GLYCAN_BIOSYNTHESIS_FKTN_TO_LARGE	LARGE2 LARGE1	1.05e-04	6	38	2	M47618
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	RPL10L PLEK2 EPRS1 LSG1 N4BP2 UBR4 U2AF2 METTL25 SRCAP TRIP12 CXXC1 RPL10 ZNF292	3.63e-07	1442	56	13	35575683
Pubmed	Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.	EPRS1 UBR4 RPS8 U2AF2 ZFHX3 CPT1A SRCAP MYO15A PCCB RPL10	5.81e-07	807	56	10	30575818
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	INTS6 RBM27 LSG1 RPS8 U2AF2 HIC2 SRCAP TRIP12 CXXC1 RPL10 ZNF292	1.04e-06	1082	56	11	38697112
Pubmed	Characterization of the LARGE family of putative glycosyltransferases associated with dystroglycanopathies.	LARGE2 LARGE1	2.55e-06	2	56	2	15958417
Pubmed	Localization and functional analysis of the LARGE family of glycosyltransferases: significance for muscular dystrophy.	LARGE2 LARGE1	2.55e-06	2	56	2	15661757
Pubmed	Genome-wide linkage scan for prostate cancer susceptibility from the University of Michigan Prostate Cancer Genetics Project: suggestive evidence for linkage at 16q23.	WWOX ZFHX3	2.55e-06	2	56	2	19035517
Pubmed	LARGE2 facilitates the maturation of alpha-dystroglycan more effectively than LARGE.	LARGE2 LARGE1	2.55e-06	2	56	2	15752776
Pubmed	The 3'UTR of the pseudogene CYP4Z2P promotes tumor angiogenesis in breast cancer by acting as a ceRNA for CYP4Z1.	CYP4Z2P CYP4Z1	2.55e-06	2	56	2	25701119
Pubmed	Mutation of Large, which encodes a putative glycosyltransferase, in an animal model of muscular dystrophy.	LARGE2 LARGE1	2.55e-06	2	56	2	12417403
Pubmed	The competing endogenous RNA network of CYP4Z1 and pseudogene CYP4Z2P exerts an anti-apoptotic function in breast cancer.	CYP4Z2P CYP4Z1	2.55e-06	2	56	2	28236635
Pubmed	Xylosyl- and glucuronyltransferase functions of LARGE in α-dystroglycan modification are conserved in LARGE2.	LARGE2 LARGE1	2.55e-06	2	56	2	23125099
Pubmed	Identification of a novel mammary-restricted cytochrome P450, CYP4Z1, with overexpression in breast carcinoma.	CYP4Z2P CYP4Z1	2.55e-06	2	56	2	15059886
Pubmed	LARGE2 generates the same xylose- and glucuronic acid-containing glycan structures as LARGE.	LARGE2 LARGE1	2.55e-06	2	56	2	23135544
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	EPRS1 INTS6 RBM27 RPS8 U2AF2 CPT1A SRCAP UBN2 TRIP12 CXXC1 RPL10	5.79e-06	1294	56	11	30804502
Pubmed	Transcriptional factor six2 promotes the competitive endogenous RNA network between CYP4Z1 and pseudogene CYP4Z2P responsible for maintaining the stemness of breast cancer cells.	CYP4Z2P CYP4Z1	7.63e-06	3	56	2	30832689
Pubmed	IFR4/MUM1-positive lymphoma in Waldeyer ring with co-expression of CD5 and CD10.	CD5 IRF4	7.63e-06	3	56	2	27616053
Pubmed	Endogenous glucuronyltransferase activity of LARGE or LARGE2 required for functional modification of α-dystroglycan in cells and tissues.	LARGE2 LARGE1	7.63e-06	3	56	2	25138275
Pubmed	Increased FGF21 in brown adipose tissue of tyrosine hydroxylase heterozygous mice: implications for cold adaptation.	DIO2 CPT1A KLB	1.00e-05	26	56	3	30352954
Pubmed	Human transcription factor protein interaction networks.	RBM27 UBR4 RPS8 IRF4 HIC2 ZFHX3 SRCAP UBN2 PCCB CXXC1 RPL10	1.47e-05	1429	56	11	35140242
Pubmed	TRIM26 promotes non-small cell lung cancer survival by inducing PBX1 degradation.	TRIM26 UBR4	1.52e-05	4	56	2	37324936
Pubmed	The ZNF75 zinc finger gene subfamily: isolation and mapping of the four members in humans and great apes.	ZNF75D ZNF75A	1.52e-05	4	56	2	8661144
Pubmed	PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry.	RPL10L EPRS1 INTS6 RBM27 RPS8 TRIP12	1.80e-05	340	56	6	24332808
Pubmed	Tumor suppressor function of laminin-binding alpha-dystroglycan requires a distinct beta3-N-acetylglucosaminyltransferase.	LARGE2 LARGE1	2.54e-05	5	56	2	19587235
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	A2M PLEK2 EPRS1 RBM27 LSG1 TRIM26 RPS8 U2AF2 TRIP12 RPL10	2.88e-05	1257	56	10	36526897
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	CD5 LSG1 RPS8 U2AF2 ZFHX3 TRIP12 PCCB RPL10	3.30e-05	777	56	8	35844135
Pubmed	Immunomodulatory Functions of BTLA and HVEM Govern Induction of Extrathymic Regulatory T Cells and Tolerance by Dendritic Cells.	CD5 IRF4	3.80e-05	6	56	2	27793593
Pubmed	FBW7 suppresses ovarian cancer development by targeting the N6-methyladenosine binding protein YTHDF2.	EPRS1 TRIM26 UBR4 RPS8 U2AF2 TRIP12 RPL10	4.95e-05	601	56	7	33658012
Pubmed	Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.	EPRS1 RBM27 LSG1 RPS8 U2AF2 CPT1A TRIP12 RPL10	6.05e-05	847	56	8	35850772
Pubmed	The RNA-binding ubiquitin ligase MKRN1 functions in ribosome-associated quality control of poly(A) translation.	RPS8 U2AF2 RPL10	9.78e-05	55	56	3	31640799
Pubmed	Identification of intracellular proteins associated with the EBV-encoded nuclear antigen 5 using an efficient TAP procedure and FT-ICR mass spectrometry.	EPRS1 RPS8 PCCB RPL10	1.05e-04	151	56	4	18457437
Pubmed	Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.	FRMD4A RBM27 N4BP2 UBR4	1.11e-04	153	56	4	10718198
Pubmed	Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.	A2M INTS6 LSG1 MTIF2 UBR4 RPL10	1.15e-04	475	56	6	31040226
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	INTS6 WWOX TRIM26 ZDHHC14 CILK1 U2AF2 ZFHX3 TTC17 CPT1A UBN2	1.18e-04	1489	56	10	28611215
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	TACO1 GLMN WWOX LSG1 TRIM26 MTIF2 UBR4 RPS8 U2AF2 TTC17	1.23e-04	1496	56	10	32877691
Pubmed	The ubiquitin-specific protease USP36 SUMOylates EXOSC10 and promotes the nucleolar RNA exosome function in rRNA processing.	A2M RPL10L RBM27 TRIM26 RPS8 RPL10	1.25e-04	483	56	6	36912080
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	RBM27 LSG1 U2AF2 UBN2 TRIP12 PCCB ZNF292	1.57e-04	724	56	7	36232890
Pubmed	A global genomic transcriptional code associated with CNS-expressed genes.	WWOX TRIM26 ARX ZFHX3 UBN2	1.61e-04	318	56	5	16919269
Pubmed	A neurogenomics approach to gene expression analysis in the developing brain.	CILK1 ZFHX3 UBN2 TRIP12	1.66e-04	170	56	4	15582152
Pubmed	Temperature dependence of the control of energy homeostasis requires CART signaling.	POMC CPT1A	1.66e-04	12	56	2	27080622
Pubmed	AGO61-dependent GlcNAc modification primes the formation of functional glycans on α-dystroglycan.	LARGE2 LARGE1	1.66e-04	12	56	2	24256719
Pubmed	Beads-free protein immunoprecipitation for a mass spectrometry-based interactome and posttranslational modifications analysis.	RPL10L RPS8 U2AF2 RPL10	1.74e-04	172	56	4	26336360
Pubmed	The necdin interactome: evaluating the effects of amino acid substitutions and cell stress using proximity-dependent biotinylation (BioID) and mass spectrometry.	A2M EPRS1 WWOX RPS8 RPL10	1.92e-04	330	56	5	32529326
Pubmed	Atbf1 is required for the Pit1 gene early activation.	POMC ZFHX3	1.96e-04	13	56	2	18272476
Pubmed	Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.	EPRS1 UBR4 U2AF2 SRCAP RPL10	1.97e-04	332	56	5	32786267
Pubmed	Lysosomal Signaling Licenses Embryonic Stem Cell Differentiation via Inactivation of Tfe3.	N4BP2 RPS8 ZFHX3 UBN2 ZNF292	1.97e-04	332	56	5	30595499
Pubmed	Proteomic analysis of human Nop56p-associated pre-ribosomal ribonucleoprotein complexes. Possible link between Nop56p and the nucleolar protein treacle responsible for Treacher Collins syndrome.	RPS8 U2AF2 RPL10	2.18e-04	72	56	3	12777385
Pubmed	Whole genome sequencing resource identifies 18 new candidate genes for autism spectrum disorder.	SRCAP UBN2	2.29e-04	14	56	2	28263302
Pubmed	The ubiquitin ligase TRIM25 targets ERG for degradation in prostate cancer.	UBR4 TRIP12	2.29e-04	14	56	2	27626314
Pubmed	RUFY1 binds Arl8b and mediates endosome-to-TGN CI-M6PR retrieval for cargo sorting to lysosomes.	EPRS1 HSP90AB4P RPS8 PCCB RPL10	2.32e-04	344	56	5	36282215
Pubmed	Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria.	TACO1 WWOX MTIF2 ZFHX3 CPT1A PCCB	2.34e-04	542	56	6	14651853
Pubmed	BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.	PLEK2 EPRS1 RBM27 UBR4 RPS8 U2AF2 TRIP12 PCCB RPL10	2.39e-04	1318	56	9	30463901
Pubmed	Localization of the muscle, liver, and brain glycogen phosphorylase genes on linkage maps of mouse chromosomes 19, 12, and 2, respectively.	CD5 POMC	2.64e-04	15	56	2	2575583
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	PLEK2 EPRS1 LSG1 UBR4 RPS8 U2AF2 SRCAP TRIP12 CXXC1	2.89e-04	1353	56	9	29467282
Pubmed	USP11 mediates repair of DNA-protein cross-links by deubiquitinating SPRTN metalloprotease.	RPL10L HSP90AB4P RPS8 CPT1A PCCB RPL10	2.92e-04	565	56	6	33567341
Pubmed	RBM4 dictates ESCC cell fate switch from cellular senescence to glutamine-addiction survival through inhibiting LKB1-AMPK-axis.	TRIM26 TRIP12	3.41e-04	17	56	2	37080995
Pubmed	Folate receptor α increases chemotherapy resistance through stabilizing MDM2 in cooperation with PHB2 that is overcome by MORAb-202 in gastric cancer.	HSP90AB4P RPS8 U2AF2 RPL10	3.45e-04	206	56	4	34185411
Pubmed	A male germ-cell-specific ribosome controls male fertility.	RPL10L RPS8 RPL10	3.56e-04	85	56	3	36517592
Pubmed	Functional proteomics mapping of a human signaling pathway.	A2M UBR4 CILK1 U2AF2 TRIP12 ZNF587B	3.71e-04	591	56	6	15231748
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	FRMD4A UBR4 ZNF292	3.81e-04	87	56	3	12465718
Pubmed	The contribution of de novo coding mutations to autism spectrum disorder.	SRCAP UBN2	3.83e-04	18	56	2	25363768
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	INTS6 LSG1 MTIF2 U2AF2 HIC2 ZFHX3 SRCAP SYT7	3.97e-04	1116	56	8	31753913
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	GLMN EPRS1 HSP90AB4P LSG1 UBR4 RPS8 U2AF2 GALNT5 RPL10	4.23e-04	1425	56	9	30948266
Pubmed	Inferring nonneutral evolution from human-chimp-mouse orthologous gene trios.	TACO1 PCCB	4.28e-04	19	56	2	14671302
Pubmed	WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage.	EPRS1 RBM27 U2AF2 SRCAP TRIP12	4.32e-04	394	56	5	27248496
Pubmed	Dysregulation of sonic hedgehog signaling causes hearing loss in ciliopathy mouse models.	A2M CILK1	4.75e-04	20	56	2	33382037
Pubmed	A New Cellular Interactome of SARS-CoV-2 Nucleocapsid Protein and Its Biological Implications.	LSG1 RPS8 RPL10	4.93e-04	95	56	3	37211047
Pubmed	Defining the membrane proteome of NK cells.	RPL10L EPRS1 LSG1 UBR4 RPS8 IRF4 CPT1A RPL10	5.37e-04	1168	56	8	19946888
Pubmed	LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells.	RPL10L EPRS1 N4BP2 UBR4 RPS8 RPL10	5.59e-04	639	56	6	23443559
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	WWOX N4BP2 UBR4 ZFHX3 PCCB	5.65e-04	418	56	5	34709266
Pubmed	Loss of TRIM31 promotes breast cancer progression through regulating K48- and K63-linked ubiquitination of p53.	EPRS1 SH2D4A RPS8 U2AF2 RPL10	5.84e-04	421	56	5	34650049
Pubmed	Perinatal deiodinase 2 expression in hepatocytes defines epigenetic susceptibility to liver steatosis and obesity.	DIO2 CPT1A	6.30e-04	23	56	2	26508642
Pubmed	The LIM homeodomain factor Lhx2 is required for hypothalamic tanycyte specification and differentiation.	POMC DIO2	6.30e-04	23	56	2	25505333
Pubmed	SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk.	EPRS1 INTS6 RPS8 U2AF2 CPT1A RPL10	6.37e-04	655	56	6	35819319
Pubmed	Heterozygous deletion of chromosome 17p renders prostate cancer vulnerable to inhibition of RNA polymerase II.	GLMN RPS8 PCCB RPL10	6.52e-04	244	56	4	30349055
Pubmed	Identification of proteins associated with ligand-activated estrogen receptor α in human breast cancer cell nuclei by tandem affinity purification and nano LC-MS/MS.	RPS8 U2AF2 TRIP12 RPL10	6.62e-04	245	56	4	21182205
Pubmed	Mitochondrial antiviral-signalling protein is a client of the BAG6 protein quality control complex.	RBM27 U2AF2	6.87e-04	24	56	2	35543156
Pubmed	Cascade diversification directs generation of neuronal diversity in the hypothalamus.	ARX POMC	6.87e-04	24	56	2	33887179
Pubmed	Proteomic analysis identifies the RNA helicase DDX3X as a host target against SARS-CoV-2 infection.	LSG1 RPS8	6.87e-04	24	56	2	33781803
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	EPRS1 WWOX RBM27 LSG1 RPS8 SRCAP RPL10	7.27e-04	934	56	7	33916271
Pubmed	TWIST1 and chromatin regulatory proteins interact to guide neural crest cell differentiation.	FRMD4A TRIP12 PCCB	7.36e-04	109	56	3	33554859
Pubmed	Characterization of Staufen 1 ribonucleoprotein complexes.	RPS8 RPL10	7.46e-04	25	56	2	15303970
Pubmed	Multi-omics profiling identifies a deregulated FUS-MAP1B axis in ALS/FTD-associated UBQLN2 mutants.	RPL10L EPRS1 CPT1A RPL10	7.80e-04	256	56	4	35777956
Pubmed	C1orf106 is a colitis risk gene that regulates stability of epithelial adherens junctions.	RPS8 RPL10	8.71e-04	27	56	2	29420262
Pubmed	Canonical Wnt signaling regulates patterning, differentiation and nucleogenesis in mouse hypothalamus and prethalamus.	ARX POMC	8.71e-04	27	56	2	30063881
Pubmed	MICALL2 as a substrate of ubiquitinase TRIM21 regulates tumorigenesis of colorectal cancer.	RPS8 U2AF2 RPL10	8.81e-04	116	56	3	36307841
Pubmed	Unbiased Profiling of the Human Proinsulin Biosynthetic Interaction Network Reveals a Role for Peroxiredoxin 4 in Proinsulin Folding.	TACO1 WWOX RPS8 CPT1A SYT7	9.03e-04	464	56	5	32457219
Pubmed	KAP1 facilitates reinstatement of heterochromatin after DNA replication.	TACO1 UBR4 RPS8 U2AF2 TRIP12 RPL10	9.26e-04	704	56	6	29955894
Pubmed	The cellular and molecular landscape of hypothalamic patterning and differentiation from embryonic to late postnatal development.	ARX ZFHX3	9.37e-04	28	56	2	32868762
Pubmed	Cul3-KLHL20 E3 ubiquitin ligase plays a key role in the arms race between HIV-1 Nef and host SERINC5 restriction.	UBR4 TRIP12	9.37e-04	28	56	2	35474067
Pubmed	Developmental gene expression profiling along the tonotopic axis of the mouse cochlea.	A2M MYO15A	9.37e-04	28	56	2	22808246
Pubmed	Insights into the ubiquitin-proteasome system of human embryonic stem cells.	A2M EPRS1 UBR4 U2AF2	9.37e-04	269	56	4	29511261
Pubmed	BPA modulates the WDR5/TET2 complex to regulate ERβ expression in eutopic endometrium and drives the development of endometriosis.	TACO1 EPRS1 UBR4 RPS8 U2AF2 RPL10	9.74e-04	711	56	6	33022573
Pubmed	Deep sequencing and proteomic analysis of the microRNA-induced silencing complex in human red blood cells.	A2M UBR4	1.01e-03	29	56	2	25681748
Pubmed	The phosphorylation status of T522 modulates tissue-specific functions of SIRT1 in energy metabolism in mice.	DIO2 CPT1A	1.01e-03	29	56	2	28364022
Pubmed	The neonatal ventromedial hypothalamus transcriptome reveals novel markers with spatially distinct patterning.	POMC LARGE1	1.01e-03	29	56	2	18077674
Pubmed	MYC multimers shield stalled replication forks from RNA polymerase.	RBM27 LSG1 RPS8 U2AF2 TRIP12 PCCB RPL10	1.01e-03	989	56	7	36424410
Pubmed	PINK1 Content in Mitochondria is Regulated by ER-Associated Degradation.	A2M EPRS1 RBM27 RPS8 RPL10	1.02e-03	477	56	5	31300519
Pubmed	Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.	GLMN HSP90AB4P UBR4 STARD7 TTC17 CPT1A TRIP12 RPL10	1.06e-03	1297	56	8	33545068
Pubmed	KAP1 Recruitment of the 7SK snRNP Complex to Promoters Enables Transcription Elongation by RNA Polymerase II.	EPRS1 TRIM26 UBR4 RPS8	1.10e-03	281	56	4	26725010
Pubmed	Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.	RBM27 U2AF2 ZFHX3 TRIP12	1.13e-03	283	56	4	30585729
Cytoband	1p33	CYP4Z2P CYP4Z1	8.47e-04	35	56	2	1p33
Cytoband	4p14	N4BP2 KLB	1.22e-03	42	56	2	4p14
Cytoband	Ensembl 112 genes in cytogenetic band chr1p33	CYP4Z2P CYP4Z1	2.55e-03	61	56	2	chr1p33
Cytoband	Ensembl 112 genes in cytogenetic band chr4p14	N4BP2 KLB	3.07e-03	67	56	2	chr4p14
Cytoband	Xq26.3	INTS6L ZNF75D	3.07e-03	67	56	2	Xq26.3
Cytoband	11p11.2	LARGE2 TTC17	4.67e-03	83	56	2	11p11.2
GeneFamily	Glycosyltransferase family 8	LARGE2 LARGE1	1.70e-04	9	40	2	436
GeneFamily	Integrator complex	INTS6L INTS6	4.92e-04	15	40	2	1366
GeneFamily	Cytochrome P450 family 4	CYP4Z2P CYP4Z1	2.87e-03	36	40	2	1003
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF75D ZNF75A HIC2 ZFHX3 ZNF587B ZNF292	4.66e-03	718	40	6	28
GeneFamily	Ankyrin repeat domain containing\|FERM domain containing	FRMD4A MYO15A	5.47e-03	50	40	2	1293
GeneFamily	L ribosomal proteins	RPL10L RPL10	5.68e-03	51	40	2	729
ToppCell	saliva-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	GLMN CD5 POMC IRF4 ZNF587B	1.99e-06	164	56	5	d8ecb3de6e34f5f574449e3d2f26fa0b2b7e84e8
ToppCell	TCGA-Head_and_Esophagus-Primary_Tumor-Head_and_Neck_Carcinoma-Squamous_Cell_Carcinoma-7\|TCGA-Head_and_Esophagus / Sample_Type by Project: Shred V9	POMC CILK1 STARD7 CCL26 PCCB	1.99e-06	164	56	5	81c41e1b5535b7969bcf6fa2456f828e8e8e2ff7
ToppCell	saliva-Severe-critical_progression_d28-40-Myeloid-Dendritic-conventional_dendritic_cell-DC_c1-CLEC9A\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	INTS6L PLEK2 CD5 ARX IRF4	2.05e-06	165	56	5	60b500eb2c10cccf309b8fb28a9119da22d6889c
ToppCell	NS-critical-d_0-4-Myeloid-Resident_Macrophage\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	RPS8 IRF4 C3orf49 RPL10	5.52e-05	165	56	4	6b1c29dcef5a945786806ddbddddcec0023bd66e
ToppCell	tumor_Lymph_Node_/_Brain-Fibroblasts-COL13A1+_matrix_FBs\|Fibroblasts / Location, Cell class and cell subclass	A2M RPS8 RPL10 ZNF292	6.06e-05	169	56	4	84b898a9fd8ced67c6a501d5cef6416f519902c4
ToppCell	343B-Myeloid-Dendritic-pDC\|Dendritic / Donor, Lineage, Cell class and subclass (all cells)	RPS8 IRF4 HIC2 ZNF587B	6.94e-05	175	56	4	b30589ff9dc18e745afe61f289e6d576c9c6c6b2
ToppCell	saliva-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	CD5 IRF4 CXXC1 ZNF587B	7.09e-05	176	56	4	6b1cf1e98b4509e87f9eea827fa7090ce1e504f1
ToppCell	lung\|World / shred on tissue and cell subclass	A2M RPS8 GALNT5 RPL10	7.41e-05	178	56	4	7b1e371272328d6b6c3994382d64281ffc737db2
ToppCell	IPF-Epithelial-ATI\|World / Disease state, Lineage and Cell class	CYP4Z2P CYP4Z1 GALNT5 SRCAP	8.25e-05	183	56	4	31fef35ecf30162662f24d335d8f0cceacc07039
ToppCell	IPF-Epithelial-ATI\|IPF / Disease state, Lineage and Cell class	CYP4Z2P CYP4Z1 GALNT5 SRCAP	8.25e-05	183	56	4	c0a3541c45bd0c587603521f392f42dd86c3c35b
ToppCell	CV-Moderate-7\|Moderate / Virus stimulation, Condition and Cluster	A2M EPRS1 TTC17 ZNF292	8.60e-05	185	56	4	a6c9203ce6c2892a4a369c9bcfb85720f01cbb3f
ToppCell	10x5'v1-week_17-19-Hematopoietic-erythroid-mid_erythroid\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	PLEK2 FRMD4A GALNT5 RFESD	8.60e-05	185	56	4	e9059cefcdf0972ec90793b1dd34c3292b17a061
ToppCell	CV-Moderate-7\|CV / Virus stimulation, Condition and Cluster	A2M EPRS1 TTC17 ZNF292	8.78e-05	186	56	4	8571956890fc9894d766ba294a28e376b4aba428
ToppCell	URO-Lymphocyte-B-B_naive\|URO / Disease, Lineage and Cell Type	LARGE2 RPS8 RPL10 LARGE1	8.96e-05	187	56	4	9ed6a39aae7126ddbd01aec3376113b6b4517383
ToppCell	Monocytes-Tissue-resident_macrophages\|World / Immune cells in Kidney/Urine in Lupus Nephritis	A2M PLEK2 FRMD4A ZFHX3	9.53e-05	190	56	4	07215e8f292cb54c670037aaf28393cddbe5548c
ToppCell	B_cell_maturation-Naive_B_cell\|World / Lineage and Cell class	LARGE2 RPS8 RPL10 LARGE1	9.92e-05	192	56	4	58267a11c938a380c6e26f4e4ce63f3b4be79fdc
ToppCell	LAM-Myeloid-DC\|Myeloid / Condition, Lineage and Cell class	A2M PLEK2 IRF4 RPL10	1.01e-04	193	56	4	f665cce40053ae5d6e28f9f70ddf78e8598c9514
ToppCell	IIH\|World / Condition, Cell_class and T cell subcluster	A2M FRMD4A RPS8 RPL10	1.01e-04	193	56	4	a9af5ccff108d51939ead130583f5b950d3092ed
ToppCell	10x_3'_v3-bone_marrow_(10x_3'_v3)-hematologic-erythrocytic-erythrocyte\|bone_marrow_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	PLEK2 FRMD4A GALNT5 RFESD	1.01e-04	193	56	4	305e15ee467826ee08b2617c69f250ad39c11b19
ToppCell	ASK454-Immune-T_cell\|Immune / Donor, Lineage and Cell class of Lung cells from Dropseq	CD5 RPS8 ZNF75A RPL10	1.01e-04	193	56	4	11e1db416dc9a0b99ddb72d6021fba6e25405b5c
ToppCell	10x_3'_v3-bone_marrow_(10x_3'_v3)-hematologic-erythrocytic\|bone_marrow_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	PLEK2 FRMD4A GALNT5 RFESD	1.01e-04	193	56	4	dd376664906caccc9c2065f8e7a364509e18a5cc
ToppCell	10x3'2.3-week_12-13-Hematopoietic-erythroid-mid_erythroid\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	PLEK2 FRMD4A GALNT5 RFESD	1.01e-04	193	56	4	1e19f80c52833fb21a8d597a3ba2c4ff464c4559
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d14-21-Lymphocytic-Lymphocytic_T\|Severe-critical_convalescent_d14-21 / Compartment, severity and other cell annotations on 10x 3' data (130k)	A2M CD5 RPS8 RPL10	1.03e-04	194	56	4	cb9f67366cfa39bd7dfd3b7a6e4672af93350958
ToppCell	healthy_donor-Lymphocytic-T_cell-Gamma_Delta_T_cell\|healthy_donor / Disease condition, Lineage, Cell class and subclass	A2M CD5 RPS8 RPL10	1.07e-04	196	56	4	6eabbac1625f715531bae562a28da27664572600
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-4M-Neuronal-ventral_progenitors_and_neurons_3\|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.	RPS8 ARX ZFHX3 RPL10	1.10e-04	197	56	4	d77bc37a77546a1f0a508486a38a45e571e4645b
ToppCell	Control-Myeloid-DC2\|Myeloid / Condition, Lineage and Cell class	A2M PLEK2 CD5 IRF4	1.10e-04	197	56	4	e0ee15188ff0d9df3c3b5ea523553ce18d223c33
ToppCell	normal_Lung-Myeloid_cells-CD1c+_DCs\|Myeloid_cells / Location, Cell class and cell subclass	PLEK2 RPS8 IRF4 RPL10	1.10e-04	197	56	4	d051617f7cf96485715c343cff72833c2124512d
ToppCell	COVID-19_Severe-B_naive\|COVID-19_Severe / disease group, cell group and cell class	LARGE2 RPS8 RPL10 LARGE1	1.10e-04	197	56	4	b8f18b39435e2229ba3bc07a25eb875d1ec11f6f
ToppCell	COVID_vent-Lymphocytic\|COVID_vent / Disease condition, Lineage, Cell class and subclass	CD5 RPS8 IRF4 RPL10	1.12e-04	198	56	4	ee80f647317377081b4bd194ee2801f556b3a53b
ToppCell	saliva-Severe-critical_progression_d28-40-Myeloid-Dendritic\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	A2M RPS8 IRF4 RPL10	1.14e-04	199	56	4	2d57afe29276995c500b74da4771b2572bc80587
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_T\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	A2M CD5 RPS8 RPL10	1.14e-04	199	56	4	accfdf22a2c9e9b926b8328efdadd24979477edf
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-10w\|organoid_Tanaka_cellReport / Sample Type, Dataset, Time_group, and Cell type.	RBM27 RPS8 RPL10 ZNF292	1.16e-04	200	56	4	ac0e023dbb383bbc46c5cc525431778be8f7ef46
Disease	T-cell acute lymphoblastic leukemia (implicated_via_orthology)	RPL10L RPL10	9.13e-06	3	52	2	DOID:5603 (implicated_via_orthology)
Disease	autistic disorder (implicated_via_orthology)	RPL10L RPL10	1.82e-05	4	52	2	DOID:12849 (implicated_via_orthology)
Disease	level of Phosphatidylcholine (18:0_20:4) in blood serum	CD5 CPT1A SYT7	2.24e-05	31	52	3	OBA_2045094
Disease	spondyloepiphyseal dysplasia congenita (implicated_via_orthology)	RPL10L RPL10	4.55e-05	6	52	2	DOID:14789 (implicated_via_orthology)
Disease	syndromic X-linked intellectual disability Najm type (implicated_via_orthology)	RPL10L RPL10	6.36e-05	7	52	2	DOID:0060807 (implicated_via_orthology)
Disease	10-undecenoate 11:1n1 measurement	CYP4Z2P CYP4Z1	6.36e-05	7	52	2	EFO_0021099
Disease	PARTINGTON X-LINKED MENTAL RETARDATION SYNDROME	ARX RPL10	8.47e-05	8	52	2	C0796250
Disease	response to ketamine	DIO2 ZFHX3 LARGE1	2.49e-04	69	52	3	EFO_0009748
Disease	level of Phosphatidylcholine (16:0_22:5) in blood serum	CPT1A SYT7	4.58e-04	18	52	2	OBA_2045079
Disease	Neurodevelopmental Disorders	SRCAP TRIP12 ZNF292	5.99e-04	93	52	3	C1535926
Disease	level of Phosphatidylcholine (16:0_20:4) in blood serum	CD5 SYT7	6.26e-04	21	52	2	OBA_2045076
Disease	Weight Gain	RPS8 POMC LARGE1	7.84e-04	102	52	3	C0043094
Disease	West Syndrome	ARX POMC	8.20e-04	24	52	2	C0037769
Disease	fatty acid measurement	CD5 CPT1A PCCB SYT7 KLB	1.01e-03	436	52	5	EFO_0005110
Disease	level of Sterol ester (27:1/20:4) in blood serum	CPT1A SYT7	1.37e-03	31	52	2	OBA_2045198
Disease	alcohol consumption measurement	FRMD4A RBM27 ZDHHC14 DIO2 IRF4 ZFHX3 MYO15A KLB	1.39e-03	1242	52	8	EFO_0007878
Disease	Diabetes Mellitus	POMC CPT1A	1.46e-03	32	52	2	C0011849

Protein segments in the cluster

Peptide	Gene	Start	Entry
SKWKKHRQIVKPGFN	CYP4Z2P	131	Q8N1L4
VKKFRQKKQRQWIGP	CD5	406	P06127
LHSWKKKFIRFKNGI	CPT1A	36	P50416
KKDNSVHWERPQKPK	A2M	1176	P01023
GPKFKDRRLQISWHK	RBM27	1001	Q9P2N5
FKVHKLKPNLKWRQA	INTS6L	401	Q5JSJ4
LFKVHKAKPTLKWRQ	INTS6	396	Q9UL03
KVIHWNSPKKLRVKN	LARGE2	336	Q8N3Y3
HWLEKNFSKRUKKTR	DIO2	256	Q92813
WNSPKKLRVKNKHVE	LARGE1	381	O95461
PWKKHGNRNKKEKSR	LSG1	636	Q9H089
QKKFKLTRNGHVIWK	MTIF2	656	P46199
EKSIFRIPWKHAGKQ	IRF4	46	Q15306
WGLHTGPQKTKRKRK	MYO15A	61	Q9UKN7
RWVKEVVKKHPQFIG	HSP90AB4P	171	Q58FF6
HGAEERNRKLKKHWK	METTL25	211	Q8N6Q8
RKKSGKWYHRRQAVK	KIAA2026	791	Q5HYC2
KAHRLQFWKKALPQK	CES2	531	O00748
MEHFRWGKPVGKKRR	POMC	141	P01189
AKPKWCSKGIKQRIH	RFESD	106	Q8TAC1
VLASKKVQRPWRKHA	PCCB	521	P05166
HDKVKPRKIFQWRQL	FRMD4A	246	Q9P2Q2
KQKHKDKWKHPERAD	CXXC1	351	Q9P0U4
KNGSFKRKGIERWHR	C3orf49	31	Q96BT1
VVPHGKEKEAERRWK	GALNT5	446	Q7Z7M9
AKWRKREKAGAQTHP	ARX	381	Q96QS3
KRRKFWKAKNLQHIP	KLB	1021	Q86Z14
DNWHKRRKTGGKRKP	RPS8	6	P62241
PKMIFNHGRKKRTWN	GLMN	256	Q92990
RHSTRKKEWGKKEPV	HIC2	331	Q96JB3
GRQKIHISKKWGFTK	RPL10L	161	Q96L21
KLETKVKRKNLNPHW	SYT7	186	O43581
EQLKQKKAPVHVKRW	EPRS1	136	P07814
KKAPVHVKRWFGFLE	EPRS1	141	P07814
GRQKIHISKKWGFTK	RPL10	161	P27635
NKWSKVRHIKGPKDV	TACO1	61	Q9BSH4
AQKERKLKRQGWTKP	SRCAP	701	Q6ZRS2
TKRGKKVCTHPRKKW	CCL26	66	Q9Y258
EHKNGEIKPKSRRRW	CILK1	391	Q9UPZ9
SKWKKHRQIVKPGFN	CYP4Z1	131	Q86W10
KQGHKRKNWKVRRFV	PLEK2	256	Q9NYT0
KPGKRVIGPRKKFHW	UBN2	591	Q6ZU65
RWKIKRIQFGFHKKD	STYXL2	546	Q5VZP5
NKRAKWPAIIRDGKF	ZNF292	1361	O60281
KTQWEHPKTGKRKRV	WWOX	41	Q9NZC7
PRPKKENGKSVHWKL	SH2D4A	56	Q9H788
RKKFWVGKPIARVVK	TRIM26	266	Q12899
EWITFQVKRVKKPKG	TTC17	836	Q96AE7
KKKIAARRKWEVFPG	ZDHHC14	31	Q8IZN3
GRPRWVDHKDRKEFK	ZNF587B	376	E7ETH6
VQKWHRAFPRKKRKK	ZNF75D	326	P51815
RHEKKKKVRKYWDVP	U2AF2	81	P26368
DKKHFKLWRRPITGT	STARD7	146	Q9NQZ5
RVGKWHQDFPVKKRK	ZNF75A	121	Q96N20
REKIKGWIKEQAHKF	TRIP12	1086	Q14669
KNKPARWHKAKKVQL	UBR4	3606	Q5T4S7
KSGLPQKVIKHWFRN	ZFHX3	2181	Q15911
WKFKPKELARRNIHG	N4BP2	546	Q86UW6