Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	AIR_synth_C_dom	PFAS SEPHS2	1.81e-05	4	33	2	IPR010918
Domain	AIRS_C	PFAS SEPHS2	1.81e-05	4	33	2	PF02769
Domain	AIRS	PFAS SEPHS2	1.81e-05	4	33	2	PF00586
Domain	-	PFAS SEPHS2	1.81e-05	4	33	2	3.30.1330.10
Domain	PurM-like_N	PFAS SEPHS2	1.81e-05	4	33	2	IPR016188
Domain	EGF_1	LAMC1 ADAM33 ITGB3 FBN3	1.02e-03	255	33	4	PS00022
Domain	EGF-like_CS	LAMC1 ADAM33 ITGB3 FBN3	1.11e-03	261	33	4	IPR013032
Domain	EGF_2	LAMC1 ADAM33 ITGB3 FBN3	1.17e-03	265	33	4	PS01186
Domain	Ntn_hydrolases_N	AGA PSMA7	1.54e-03	33	33	2	IPR029055
Domain	EGF_extracell	ADAM33 ITGB3	5.03e-03	60	33	2	IPR013111
Domain	EGF_2	ADAM33 ITGB3	5.03e-03	60	33	2	PF07974
Domain	EGF	LAMC1 ADAM33 FBN3	8.12e-03	235	33	3	SM00181
Domain	EGF-like_dom	LAMC1 ADAM33 FBN3	9.51e-03	249	33	3	IPR000742
Pubmed	Energy stress-induced lncRNA FILNC1 represses c-Myc-mediated energy metabolism and inhibits renal tumor development.	LAMC1 PFAS OGT AKAP8	1.62e-06	90	33	4	28978906
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	PEX19 LAMC1 DUSP28 PFAS OGT AKAP8 NAP1L5	2.99e-05	974	33	7	28675297
Pubmed	Understanding the cell fate and behavior of progenitors at the origin of the mouse cardiac mitral valve.	MSX1 ITGB3	3.13e-05	9	33	2	38198889
Pubmed	FBXO32 links ubiquitination to epigenetic reprograming of melanoma cells.	APPL1 OGT AKAP8 PC	4.78e-05	212	33	4	33462405
Pubmed	IKKα and alternative NF-κB regulate PGC-1β to promote oxidative muscle metabolism.	PPARGC1B NFKBIB	1.18e-04	17	33	2	22351927
Pubmed	Laminin and integrin expression in the ventral ectodermal ridge of the mouse embryo: implications for regulation of BMP signalling.	MSX1 LAMC1	1.64e-04	20	33	2	22911573
Pubmed	Bone morphogenetic protein receptor 1A signaling is dispensable for hematopoietic development but essential for vessel and atrioventricular endocardial cushion formation.	MSX1 ITGB3	2.58e-04	25	33	2	16887829
Pubmed	The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.	HELZ2 PEX19 LAMC1 KCNJ4	2.68e-04	332	33	4	37433992
Pubmed	Alterations in the brain interactome of the intrinsically disordered N-terminal domain of the cellular prion protein (PrPC) in Alzheimer's disease.	APPL1 PFAS NPTX1 PSMA7	2.97e-04	341	33	4	29791485
Pubmed	Genetic polymorphisms in adaptive immunity genes and childhood acute lymphoblastic leukemia.	ADAM33 NFKBIB	3.49e-04	29	33	2	20716621
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	HELZ2 PFAS SEPHS2 WDR90 PC SPEG	5.39e-04	1105	33	6	35748872
Pubmed	Assessing the reproducibility of asthma candidate gene associations, using genome-wide data.	ADAM33 ITGB3	6.01e-04	38	33	2	19264973
Pubmed	Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells.	OGT AKAP8 PSMA7	6.32e-04	177	33	3	26206133
Pubmed	Oct4 links multiple epigenetic pathways to the pluripotency network.	LAMC1 OGT AKAP8	9.40e-04	203	33	3	22083510
Interaction	FILNC1 interactions	LAMC1 PFAS OGT AKAP8	1.32e-05	89	33	4	int:FILNC1
Cytoband	16p13.3	WDR90 PGP MSLNL	7.19e-04	244	33	3	16p13.3
Cytoband	20q13.33	HELZ2 PSMA7	1.49e-03	79	33	2	20q13.33
Cytoband	Ensembl 112 genes in cytogenetic band chr16p13	WDR90 PGP MSLNL	3.52e-03	426	33	3	chr16p13
Drug	Grgds	LAMC1 ITGB3 SPEG RNF112	6.20e-06	83	33	4	CID000123811
Drug	FR-3	IMPA1 AGA KCNJ4	2.08e-05	37	33	3	CID000447341
Drug	AC1NDS56	APPL1 NPTX1 RNF112	2.64e-05	40	33	3	CID004630712
Drug	dichloroacetyl chloride	APPL1 PPARGC1B	3.04e-05	6	33	2	CID000006593
Disease	colorectal carcinoma (is_marker_for)	SEPHS2 ITGB3	7.88e-04	37	33	2	DOID:0080199 (is_marker_for)
Disease	response to fenofibrate	PPARGC1B PSMA7	1.44e-03	50	33	2	GO_1901557
Disease	Malignant neoplasm of breast	APPL1 ADAM33 PPARGC1B AKAP8 GEN1	6.44e-03	1074	33	5	C0006142
Disease	chronic obstructive pulmonary disease	ASCC2 ADAM33 PPARGC1B SPEG	7.01e-03	688	33	4	EFO_0000341

Protein segments in the cluster

Peptide	Gene	Start	Entry
LDGAVDMGARGAAAC	ALDH16A1	336	Q8IZ83
AAEAGNGAETMAAEA	AKAP8	646	O43823
NSEEEECMGAAAAVG	ASCC2	446	Q9H1I8
CVEAAAESGGCVMAA	ADAM33	361	Q9BZ11
DGAMCRDVDECADGQ	FBN3	2201	Q75N90
CAAMEAAVRAGGACL	DUSP28	86	Q4G0W2
EMEEEAAAAAAVAAG	KCNJ4	386	P48050
PVDADMCAASVAAGG	NPTX1	36	Q15818
MCAASVAAGGAEELR	NPTX1	41	Q15818
DVAGGLAMDIDNCSV	APPL1	316	Q9UKG1
MAGVACLGKAADADE	NFKBIB	1	Q15653
MAAAEAGGDDARCVR	PGP	1	A6NDG6
ALVCDMDASSIGAAD	MSLNL	181	Q96KJ4
MAAAEEGCSVGAEAD	PEX19	1	P40855
METAAAGSAGLAAEV	KLHL11	26	Q9NVR0
ALGDSDDEACASAML	FNIP2	896	Q9P278
GSALDAVESGCAMCE	AGA	51	P20933
AAGEAEAMCAYLNAG	GEN1	131	Q17RS7
EGGFDAIMQATVCDE	ITGB3	246	P05106
AAAAAGCAQAAMDEC	LAMC1	26	P11047
LDCGMAFAGDEVLVQ	HELZ2	1161	Q9BYK8
AALVAAGDMEGAVQA	OGT	131	O15294
AAATAAAMGADEEGA	MSX1	36	P28360
AAVNMCLVATGGADA	IMPA1	196	P29218
AAAAEAAAEEVMAEG	NAP1L5	16	Q96NT1
MAGNDCGALLDEELS	PPARGC1B	1	Q86YN6
MAEASATGACGEAMA	SEPHS2	1	Q99611
ATGACGEAMAAAEGS	SEPHS2	6	Q99611
RLVDCAMGTAQDFAG	WDR90	1701	Q96KV7
MAAPSGGVNCEEFAE	MIX23	1	Q4VC31
AAAALAAEAGMVAAG	RNF112	571	Q9ULX5
DVDVGAGEMALFECL	SPEG	976	Q15772
GEGAALADACEAMVA	PFAS	776	O15067
DDNVCMAFAGLTADA	PSMA7	66	O14818
AAMLACAQAGADVVD	PC	781	P11498