Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionATP hydrolysis activity

KIF1A ABCA13 DDX54 PSMC6 CHD3 HSPA2 DNAH7 HSPA6 HSPA7 NLRP3

3.03e-064417010GO:0016887
GeneOntologyMolecularFunctionATP-dependent activity

UBA5 KIF1A ABCA13 DDX54 PSMC6 CHD3 HSPA2 DNAH7 HSPA6 HSPA7 NLRP3

8.86e-066147011GO:0140657
GeneOntologyMolecularFunctionribonucleoside triphosphate phosphatase activity

KIF1A ABCA13 DDX54 PSMC6 CHD3 GNAS HSPA2 DNAH7 HSPA6 HSPA7 NLRP3

7.50e-057757011GO:0017111
GeneOntologyMolecularFunctionalpha-tocopherol omega-hydroxylase activity

CYP4F8 CYP4F12

1.20e-045702GO:0052871
GeneOntologyMolecularFunctionpyrophosphatase activity

KIF1A ABCA13 DDX54 PSMC6 CHD3 GNAS HSPA2 DNAH7 HSPA6 HSPA7 NLRP3

1.51e-048397011GO:0016462
GeneOntologyMolecularFunctionhydrolase activity, acting on acid anhydrides

KIF1A ABCA13 DDX54 PSMC6 CHD3 GNAS HSPA2 DNAH7 HSPA6 HSPA7 NLRP3

1.53e-048407011GO:0016817
GeneOntologyMolecularFunctionhydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

KIF1A ABCA13 DDX54 PSMC6 CHD3 GNAS HSPA2 DNAH7 HSPA6 HSPA7 NLRP3

1.53e-048407011GO:0016818
GeneOntologyMolecularFunctionleukotriene-B4 20-monooxygenase activity

CYP4F8 CYP4F12

2.52e-047702GO:0050051
GeneOntologyMolecularFunctionalkane 1-monooxygenase activity

CYP4F8 CYP4F12

2.52e-047702GO:0018685
GeneOntologyMolecularFunctionactin binding

CTNNAL1 TRPM7 CAMK2B SCNN1A SYN1 ANTXR1 TNS1 CNN3

2.65e-04479708GO:0003779
GeneOntologyMolecularFunctionATP-dependent protein folding chaperone

HSPA2 HSPA6 HSPA7

3.71e-0440703GO:0140662
GeneOntologyMolecularFunctioncytoskeletal protein binding

TPR CTNNAL1 KIF1A TRPM7 CAMK2B SCNN1A SYN1 ANTXR1 GNAS TNS1 HSPA2 CNN3

4.00e-0410997012GO:0008092
GeneOntologyMolecularFunctionarachidonate omega-hydroxylase activity

CYP4F8 CYP4F12

5.35e-0410702GO:0052869
GeneOntologyMolecularFunctionfatty acid omega-hydroxylase activity

CYP4F8 CYP4F12

5.35e-0410702GO:0120250
GeneOntologyMolecularFunctionlong-chain fatty acid omega-hydroxylase activity

CYP4F8 CYP4F12

5.35e-0410702GO:0102033
GeneOntologyMolecularFunctionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen

CYP4F8 CYP4F12

9.22e-0413702GO:0016713
GeneOntologyMolecularFunctionarachidonate binding

CYP4F8 CYP4F12

1.24e-0315702GO:0050544
GeneOntologyMolecularFunctionicosanoid binding

CYP4F8 CYP4F12

1.41e-0316702GO:0050542
GeneOntologyMolecularFunctionicosatetraenoic acid binding

CYP4F8 CYP4F12

1.41e-0316702GO:0050543
GeneOntologyMolecularFunctionprotein folding chaperone

HSPA2 HSPA6 HSPA7

2.15e-0373703GO:0044183
GeneOntologyMolecularFunctionphosphoric ester hydrolase activity

PTPN12 NT5E INPP5K PDP2 GNAS TNS1

2.32e-03386706GO:0042578
GeneOntologyMolecularFunctionheat shock protein binding

TPR HSPA2 HSPA6 HSPA7

2.58e-03163704GO:0031072
GeneOntologyMolecularFunctionarachidonate epoxygenase activity

CYP4F8 CYP4F12

3.18e-0324702GO:0008392
GeneOntologyMolecularFunctioncytoskeletal anchor activity

SYN1 NCK1

3.18e-0324702GO:0008093
GeneOntologyMolecularFunctionphosphatase activity

PTPN12 NT5E INPP5K PDP2 TNS1

3.35e-03287705GO:0016791
GeneOntologyCellularComponentCOP9 signalosome

GRB2 HSPA6 HSPA7

2.67e-0438693GO:0008180
GeneOntologyCellularComponentNLRP3 inflammasome complex

GSDMD NLRP3

2.97e-048692GO:0072559
DomainHSP70

HSPA2 HSPA6 HSPA7

2.73e-0516703PF00012
DomainHSP70_2

HSPA2 HSPA6 HSPA7

3.30e-0517703PS00329
DomainHSP70_3

HSPA2 HSPA6 HSPA7

3.30e-0517703PS01036
DomainHSP70_1

HSPA2 HSPA6 HSPA7

3.30e-0517703PS00297
DomainHsp_70_fam

HSPA2 HSPA6 HSPA7

3.95e-0518703IPR013126
Domain-

HSPA2 HSPA6

8.92e-04127022.60.34.10
DomainHSP70_peptide-bd

HSPA2 HSPA6

8.92e-0412702IPR029047
Domain-

HSPA2 HSPA6

1.05e-03137021.20.1270.10
DomainHeat_shock_70_CS

HSPA2 HSPA6

1.05e-0313702IPR018181
DomainHSP70_C

HSPA2 HSPA6

1.05e-0313702IPR029048
DomainQuino_amine_DH_bsu

WDR36 BRWD3

3.05e-0322702IPR011044
DomainSH2

GRB2 NCK1 TNS1

6.46e-03101703PF00017
Pubmed

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.

PTPN12 CTNNAL1 RPGRIP1L CD2BP2 INTS11 DDX54 GRB2 PDP2 PSMC6 PFAS TNS1 HSPA2 HSPA6

1.53e-071049701327880917
Pubmed

Expression and significance of effector proteins NLRP3 and gasdermin D N-terminal protein in the pyrolysis pathway in breast cancer.

GSDMD NLRP3

3.99e-06270237800794
Pubmed

The human heat-shock genes HSPA6 and HSPA7 are both expressed and localize to chromosome 1.

HSPA6 HSPA7

3.99e-0627021346391
Pubmed

NLRP3 inflammasome activation triggers gasdermin D-independent inflammation.

GSDMD NLRP3

3.99e-06270234678046
Pubmed

Nck1 and Grb2 localization patterns can distinguish invadopodia from podosomes.

GRB2 NCK1

3.99e-06270220850195
Pubmed

Oxygenation of polyunsaturated long chain fatty acids by recombinant CYP4F8 and CYP4F12 and catalytic importance of Tyr-125 and Gly-328 of CYP4F8.

CYP4F8 CYP4F12

3.99e-06270216112640
Pubmed

Grb2 and Nck act cooperatively to promote actin-based motility of vaccinia virus.

GRB2 NCK1

3.99e-06270212007418
Pubmed

Gasdermin-D activation promotes NLRP3 activation and host resistance to Leishmania infection.

GSDMD NLRP3

3.99e-06270236828815
Pubmed

Interaction of Grb2 via its Src homology 3 domains with synaptic proteins including synapsin I.

GRB2 SYN1

3.99e-0627028022809
Pubmed

Acinar cell NLRP3 inflammasome and gasdermin D (GSDMD) activation mediates pyroptosis and systemic inflammation in acute pancreatitis.

GSDMD NLRP3

3.99e-06270233871879
Pubmed

A proteomic investigation of ligand-dependent HSP90 complexes reveals CHORDC1 as a novel ADP-dependent HSP90-interacting protein.

HSPA2 HSPA6 HSPA7 FAM83H

7.20e-066170419875381
Pubmed

C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.

MAT2A CAMK2B TPP1 CD2BP2 GRB2 PSMC6 PFAS RDH13 GNAS HSPA2 HSPA6 GTF3C4

7.23e-061257701237317656
Pubmed

N-Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS-CoV-2 Main Protease.

UBA5 TPR GSDMD CD2BP2 TRIP11 CNN3 PGM1

8.23e-0636070733111431
Pubmed

The Inflammasome Drives GSDMD-Independent Secondary Pyroptosis and IL-1 Release in the Absence of Caspase-1 Protease Activity.

GSDMD NLRP3

1.20e-05370229281832
Pubmed

Deficiency of circadian clock gene Bmal1 exacerbates noncanonical inflammasome-mediated pyroptosis and lethality via Rev-erbα-C/EBPβ-SAA1 axis.

GSDMD NLRP3

1.20e-05370238297162
Pubmed

Chromosome locations of genes encoding human signal transduction adapter proteins, Nck (NCK), Shc (SHC1), and Grb2 (GRB2).

GRB2 NCK1

1.20e-0537027806213
Pubmed

Yersiniabactin-Producing E. coli Induces the Pyroptosis of Intestinal Epithelial Cells via the NLRP3 Pathway and Promotes Gut Inflammation.

GSDMD NLRP3

1.20e-05370237511208
Pubmed

Vitamin D/VDR attenuate cisplatin-induced AKI by down-regulating NLRP3/Caspase-1/GSDMD pyroptosis pathway.

GSDMD NLRP3

1.20e-05370233259938
Pubmed

NLRP3 inflammasome of microglia promotes A1 astrocyte transformation, neo-neuron decline and cognition impairment in endotoxemia.

GSDMD NLRP3

1.20e-05370235247698
Pubmed

Gasdermin D mediates the pathogenesis of neonatal-onset multisystem inflammatory disease in mice.

GSDMD NLRP3

1.20e-05370230388107
Pubmed

TLR4-NLRP3-GSDMD-Mediated Pyroptosis Plays an Important Role in Aggravated Liver Injury of CD38-/- Sepsis Mice.

GSDMD NLRP3

1.20e-05370233860064
Pubmed

Neutrophils Facilitate Prolonged Inflammasome Response in the DAMP-Rich Inflammatory Milieu.

GSDMD NLRP3

1.20e-05370234659244
Pubmed

IL-6 promotes M2 macrophage polarization by modulating purinergic signaling and regulates the lethal release of nitric oxide during Trypanosoma cruzi infection.

NT5E NLRP3

1.20e-05370228087471
Pubmed

Coupling of the murine protein tyrosine phosphatase PEST to the epidermal growth factor (EGF) receptor through a Src homology 3 (SH3) domain-mediated association with Grb2.

PTPN12 GRB2

1.20e-0537029135065
Pubmed

NLRP3-GSDMD-dependent IL-1β Secretion from Microglia Mediates Learning and Memory Impairment in a Chronic Intermittent Hypoxia-induced Mouse Model.

GSDMD NLRP3

1.20e-05370238154620
Pubmed

Pannexin-1 promotes NLRP3 activation during apoptosis but is dispensable for canonical or noncanonical inflammasome activation.

GSDMD NLRP3

1.20e-05370231411729
Pubmed

Binding of NCK to SOS and activation of ras-dependent gene expression.

GRB2 NCK1

1.20e-0537027862111
Pubmed

Post-phagocytosis activation of NLRP3 inflammasome by two novel T6SS effectors.

GSDMD NLRP3

1.20e-05370236155655
Pubmed

Emulsion and liposome-based adjuvanted R21 vaccine formulations mediate protection against malaria through distinct immune mechanisms.

GSDMD NLRP3

1.20e-05370237913775
Pubmed

Cigarette smoke-induced gasdermin D activation in bronchoalveolar macrophages and bronchial epithelial cells dependently on NLRP3.

GSDMD NLRP3

1.20e-05370236045672
Pubmed

[Expressions of NLRP3, Caspase-1, and GSDMD in nasopharyngeal carcinoma tissue and association with recurrence and metastasis].

GSDMD NLRP3

1.20e-05370238186096
Pubmed

High Glucose Induces the Loss of Retinal Pericytes Partly via NLRP3-Caspase-1-GSDMD-Mediated Pyroptosis.

GSDMD NLRP3

1.20e-05370232420343
Pubmed

PIK3CG Regulates NLRP3/GSDMD-Mediated Pyroptosis in Septic Myocardial Injury.

GSDMD NLRP3

1.20e-05370237676465
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

TPR PTPN12 WDR36 MAT2A TPP1 INTS11 DDX54 PSMC6 PFAS HSPA6 GTF3C4 FAM83H

1.51e-051353701229467282
Pubmed

Radiation causes tissue damage by dysregulating inflammasome-gasdermin D signaling in both host and transplanted cells.

GSDMD NLRP3

2.39e-05470232760056
Pubmed

c-ABL modulates MAP kinases activation downstream of VEGFR-2 signaling by direct phosphorylation of the adaptor proteins GRB2 and NCK1.

GRB2 NCK1

2.39e-05470222327338
Pubmed

Disruption of mouse cytochrome p450 4f14 (Cyp4f14 gene) causes severe perturbations in vitamin E metabolism.

CYP4F8 CYP4F12

2.39e-05470222665481
Pubmed

The Adjuvant Combination of dmLT and Monophosphoryl Lipid A Activates the Canonical, Nonpyroptotic NLRP3 Inflammasome in Dendritic Cells and Significantly Interacts to Expand Antigen-Specific CD4 T Cells.

GSDMD NLRP3

2.39e-05470237023458
Pubmed

IRAK-M suppresses the activation of microglial NLRP3 inflammasome and GSDMD-mediated pyroptosis through inhibiting IRAK1 phosphorylation during experimental autoimmune encephalomyelitis.

GSDMD NLRP3

2.39e-05470236765034
Pubmed

Francisella induced microparticulate caspase-1/gasdermin-D activation is regulated by NLRP3 independent of Pyrin.

GSDMD NLRP3

2.39e-05470230596757
Pubmed

Expression and catalytic activity of mouse leukotriene B4 omega-hydroxylase, CYP4F14.

CYP4F8 CYP4F12

2.39e-05470211185557
Pubmed

A positive feedback cycle between the alarmin S100A8/A9 and NLRP3 inflammasome-GSDMD signalling reinforces the innate immune response in Candida albicans keratitis.

GSDMD NLRP3

2.39e-05470237335321
Pubmed

IL-1 and IL-1ra are key regulators of the inflammatory response to RNA vaccines.

GSDMD NLRP3

2.39e-05470235332327
Pubmed

P2X7R Modulates NEK7-NLRP3 Interaction to Exacerbate Experimental Autoimmune Prostatitis via GSDMD-mediated Prostate Epithelial Cell Pyroptosis.

GSDMD NLRP3

2.39e-05470238993566
Pubmed

Identification and characterization of a new family of guanine nucleotide exchange factors for the ras-related GTPase Ral.

GRB2 NCK1

2.39e-05470210747847
Pubmed

Orphan GPR110 (ADGRF1) targeted by N-docosahexaenoylethanolamine in development of neurons and cognitive function.

SYN1 GNAS

2.39e-05470227759003
Pubmed

TNF-ɑ induces mitochondrial dysfunction to drive NLRP3/Caspase-1/GSDMD-mediated pyroptosis in MCF-7 cells.

GSDMD NLRP3

2.39e-05470239468189
Pubmed

Association of Nck with tyrosine-phosphorylated SLP-76 in activated T lymphocytes.

GRB2 NCK1

2.39e-05470210229072
Pubmed

Characterization of interactions of Nck with Sos and dynamin.

GRB2 NCK1

2.39e-05470210206341
Pubmed

A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.

PTPN12 CTNNAL1 KIF1A MAT2A DDX54 GRB2 PSMC6 PFAS NCK1 GNAS

2.46e-05974701028675297
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

TPR WDR36 KIF1A MAT2A CAMK2B CHAF1A INTS11 DDX54 PSMC6 PFAS APOB GNAS

2.52e-051425701230948266
Pubmed

Abl protein-tyrosine kinase selects the Crk adapter as a substrate using SH3-binding sites.

GRB2 NCK1

3.98e-0557027926767
Pubmed

Disruption of P450-mediated vitamin E hydroxylase activities alters vitamin E status in tocopherol supplemented mice and reveals extra-hepatic vitamin E metabolism.

CYP4F8 CYP4F12

3.98e-05570222969154
Pubmed

Fibronectin-stimulated signaling from a focal adhesion kinase-c-Src complex: involvement of the Grb2, p130cas, and Nck adaptor proteins.

GRB2 NCK1

3.98e-0557029032297
Pubmed

Cbl functions downstream of Src kinases in Fc gamma RI signaling in primary human macrophages.

GRB2 NCK1

3.98e-05570210204582
Pubmed

Interaction of hematopoietic progenitor kinase 1 with adapter proteins Crk and CrkL leads to synergistic activation of c-Jun N-terminal kinase.

GRB2 NCK1

3.98e-0557029891069
Pubmed

Characterization of Cbl-Nck and Nck-Pak1 interactions in myeloid FcgammaRII signaling.

GRB2 NCK1

3.98e-0557029851874
Pubmed

The Mechanism of Osteoprotegerin-Induced Osteoclast Pyroptosis In Vitro.

GSDMD NLRP3

3.98e-05570236675029
Pubmed

NLRP3 selectively drives IL-1β secretion by Pseudomonas aeruginosa infected neutrophils and regulates corneal disease severity.

GSDMD NLRP3

3.98e-05570237730693
Pubmed

Cytochrome P4504f, a potential therapeutic target limiting neuroinflammation.

CYP4F8 CYP4F12

3.98e-05570221466787
Pubmed

Fine mapping of Ath6, a quantitative trait locus for atherosclerosis in mice.

KCNS3 APOB

3.98e-05570211420610
Pubmed

Phosphatidylinositol 4,5-biphosphate (PIP2)-induced vesicle movement depends on N-WASP and involves Nck, WIP, and Grb2.

GRB2 NCK1

3.98e-05570212147689
Pubmed

Novel Src homology 3 domain-binding motifs identified from proteomic screen of a Pro-rich region.

GRB2 NCK1

3.98e-05570215929943
Pubmed

FXR Inhibits Endoplasmic Reticulum Stress-Induced NLRP3 Inflammasome in Hepatocytes and Ameliorates Liver Injury.

NCK1 NLRP3

3.98e-05570230208322
Pubmed

Tyrosine phosphorylation of p62(Dok) induced by cell adhesion and insulin: possible role in cell migration.

GRB2 NCK1

3.98e-05570210202139
Pubmed

Neph1 cooperates with nephrin to transduce a signal that induces actin polymerization.

GRB2 NCK1

3.98e-05570217923684
Pubmed

Atypical mechanism of regulation of the Wrch-1 Rho family small GTPase.

GRB2 NCK1

3.98e-05570215556869
Pubmed

PrPC directly interacts with proteins involved in signaling pathways.

GRB2 SYN1

3.98e-05570211571277
Pubmed

Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion.

GSDMD NLRP3

3.98e-05570226611636
Pubmed

Differential expression and subcellular distribution of the mouse metastasis-associated proteins Mta1 and Mta3.

GRB2 NCK1

3.98e-05570211483358
Pubmed

Cutting Edge: The Heat Shock Protein gp96 Activates Inflammasome-Signaling Platforms in APCs.

GSDMD NLRP3

3.98e-05570230209191
Pubmed

A role of amphiphysin in synaptic vesicle endocytosis suggested by its binding to dynamin in nerve terminals.

GRB2 SYN1

3.98e-0557028552632
Pubmed

Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage.

TPR WDR36 MAT2A TPP1 GRB2 CHD3 HSPA2 HSPA6 HSPA7

4.84e-0584470925963833
Pubmed

Proteomic characterization of chromosomal common fragile site (CFS)-associated proteins uncovers ATRX as a regulator of CFS stability.

TPR WDR36 ABCA13 CHAF1A PSMC6 APOB GNAS HSPA6

4.96e-0565270831180492
Pubmed

T cell activation induces direct binding of the Crk adapter protein to the regulatory subunit of phosphatidylinositol 3-kinase (p85) via a complex mechanism involving the Cbl protein.

GRB2 NCK1

5.96e-05670211418612
Pubmed

Induced direct binding of the adapter protein Nck to the GTPase-activating protein-associated protein p62 by epidermal growth factor.

GRB2 NCK1

5.96e-0567029362449
Pubmed

NIK is a new Ste20-related kinase that binds NCK and MEKK1 and activates the SAPK/JNK cascade via a conserved regulatory domain.

GRB2 NCK1

5.96e-0567029135144
Pubmed

The cytochrome P450 4 (CYP4) family.

CYP4F8 CYP4F12

5.96e-0567029068972
Pubmed

APOL1 risk variants in individuals of African genetic ancestry drive endothelial cell defects that exacerbate sepsis.

GSDMD NLRP3

5.96e-05670234715018
Pubmed

Early endosome autoantigen 1 regulates IL-1β release upon caspase-1 activation independently of gasdermin D membrane permeabilization.

GSDMD NLRP3

5.96e-05670230962463
Pubmed

DNA hypomethylation promotes the expression of CASPASE-4 which exacerbates inflammation and amyloid-β deposition in Alzheimer's disease.

GSDMD NLRP3

5.96e-05670238326859
Pubmed

BLNK: a central linker protein in B cell activation.

GRB2 NCK1

5.96e-0567029697839
Pubmed

Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair.

CTNNAL1 MAT2A TPP1 GRB2 PSMC6 CHD3 GNAS HSPA2 HSPA6 GTF3C4 CNN3

6.92e-051335701129229926
Pubmed

Involvement of hematopoietic progenitor kinase 1 in T cell receptor signaling.

GRB2 NCK1

8.33e-05770211279207
Pubmed

Cullin1 binds and promotes NLRP3 ubiquitination to repress systematic inflammasome activation.

PGM1 NLRP3

8.33e-05770230653357
Pubmed

SNX9 as an adaptor for linking synaptojanin-1 to the Cdc42 effector ACK1.

GRB2 NCK1

8.33e-05770216137687
Pubmed

Protein tyrosine phosphatase-PEST regulates focal adhesion disassembly, migration, and cytokinesis in fibroblasts.

PTPN12 GRB2

8.33e-05770210085298
Pubmed

SH3 binding domains in the dopamine D4 receptor.

GRB2 NCK1

8.33e-0577029843378
Pubmed

Myeloid OTULIN deficiency couples RIPK3-dependent cell death to Nlrp3 inflammasome activation and IL-1β secretion.

GSDMD NLRP3

8.33e-05770238000038
Pubmed

The kinase-deficient Src acts as a suppressor of the Abl kinase for Cbl phosphorylation.

GRB2 NCK1

8.33e-05770210829062
Pubmed

Identification of a ten-amino acid proline-rich SH3 binding site.

GRB2 NCK1

8.33e-0577028438166
Pubmed

Phosphorylation of Tyr1214 within VEGFR-2 triggers the recruitment of Nck and activation of Fyn leading to SAPK2/p38 activation and endothelial cell migration in response to VEGF.

GRB2 NCK1

8.33e-05770216966330
Pubmed

Mycobacterial EST12 activates a RACK1-NLRP3-gasdermin D pyroptosis-IL-1β immune pathway.

GSDMD NLRP3

8.33e-05770233097533
Pubmed

Association of signaling proteins with a nonmitogenic heterodimeric complex composed of epidermal growth factor receptor and kinase-inactive p185c-neu.

GRB2 NCK1

8.33e-0577028561895
Pubmed

Use of signal specific receptor tyrosine kinase oncoproteins reveals that pathways downstream from Grb2 or Shc are sufficient for cell transformation and metastasis.

TPR GRB2

8.33e-05770211896612
Pubmed

Interaction of heterotrimeric G protein Galphao with Purkinje cell protein-2. Evidence for a novel nucleotide exchange factor.

PCP2 GNAS

8.33e-05770210196137
Pubmed

Interactions between Src homology (SH) 2/SH3 adapter proteins and the guanylnucleotide exchange factor SOS are differentially regulated by insulin and epidermal growth factor.

GRB2 NCK1

8.33e-0577028810325
Pubmed

Gab2, a new pleckstrin homology domain-containing adapter protein, acts to uncouple signaling from ERK kinase to Elk-1.

GRB2 NCK1

8.33e-05770210391903
Pubmed

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling.

GSDMD NLRP3

8.33e-05770226375259
Pubmed

Apaf-1 Pyroptosome Senses Mitochondrial Permeability Transition.

GSDMD NLRP3

8.33e-05770233308446
GeneFamilyHeat shock 70kDa proteins

HSPA2 HSPA6 HSPA7

1.57e-0517533583
ToppCellfacs-Lung-ENDOMUCIN-18m-Lymphocytic-CD4-positive,_alpha-beta_T_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCED1B CELSR1 NT5E GAN CHD3 PRKCQ BRWD3

7.12e-091637074af92b211d12c5b88b65bb746242cd702b545bd0
ToppCellfacs-Lung-ENDOMUCIN-18m-Lymphocytic-CD4+_T|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCED1B CELSR1 NT5E GAN CHD3 PRKCQ BRWD3

7.12e-09163707d24774e0aa612322c22fdb3b314aef275fa01d68
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ZHX3 ABCA13 PRKCQ CPM TNS1 DNAH7

4.85e-07186706f0c8de4f6ae9047b9108a47a2af8c5f42bc103b0
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Degenerative_Descending_Thin_Limb_Cell_Type_3|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ZHX3 ABCA13 PRKCQ CPM TNS1 DNAH7

5.00e-07187706c31130fc2f9f882944b2ba366a034a03f051c4b9
ToppCellBrain_organoid-organoid_Paulsen_bioRxiv-1_mon-Proliferating-Cycling_Progenitors|1_mon / Sample Type, Dataset, Time_group, and Cell type.

CELSR1 WDR36 MAT2A TPP1 ANTXR1 PGM1

7.19e-07199706358c4b3037f59378db8916a2fbe9ed4830cf1449
ToppCelldroplet-Lung-30m-Hematologic-lymphocytic-CD4-positive,_alpha-beta_T_cell-CD4-positive,_alpha-beta_T_cell_l5|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PCED1B NT5E CHD3 PRKCQ BBS9

8.52e-06176705218a072882d387adbbad6916d7214099c7354465
ToppCelldroplet-Heart-nan-3m|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IGSF10 TPR ZHX3 TRPM7 TRIP11

8.52e-06176705749b47eac5436fa34e0d243ffbc6f1897f4e431e
ToppCelldroplet-Kidney-KIDNEY-1m-Epithelial-Epcam_____kidney_distal_convoluted_tubule_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRPM7 ABCA13 SCNN1A ANTXR1 CPM

1.03e-05183705f3728b1a51951c7349f77a3e4d2671ca3a8d2a44
ToppCelldroplet-Kidney-KIDNEY-1m-Epithelial-kidney_distal_convoluted_tubule_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRPM7 ABCA13 SCNN1A ANTXR1 CPM

1.06e-051847058939b6d795992775df0ff58ed1ec9d421a00bcc4
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ZHX3 ABCA13 PRKCQ CPM DNAH7

1.17e-05188705af740fa78542438fdff627ea1f74f4eee43316be
ToppCellPND07|World / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PRSS35 IGSF10 ANTXR1 CPM CNN3

1.30e-051927058171a60df481195c39a7f740effcae8e4deb6ca7
ToppCellwk_20-22-Mesenchymal-Myofibro_&_SMC-Vascular_SMC_1|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

PRSS35 ANTXR1 KCNS3 HSPA2 CNN3

1.33e-05193705ba6eb29478d16589172f48f9992e5116328c81d6
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CABP1 TRPM7 SCNN1A GNAS HSPA2

1.40e-051957053123e02d2894c83962ba402085b5e6422ebf8c73
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PRSS35 CABP1 SCNN1A GNAS HSPA2

1.43e-051967051bfc3c85ce9501f52a912e53cbded7de74572b9d
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PRSS35 CABP1 SCNN1A GNAS HSPA2

1.43e-05196705e02301642243df483fd066d978317c113c04692b
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CABP1 TRPM7 SCNN1A CPM HSPA2

1.51e-05198705688b0eb5534dde40b8630ab8a3252c816711e02e
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PRSS35 CABP1 SCNN1A GNAS HSPA2

1.51e-051987054448d13511485a44fe7b549e4b8b6ad7637db624
ToppCellNS-control|NS / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

CELSR1 ABCA13 SCNN1A GAN CNN3

1.58e-05200705ecbe89ff95d046155b984c8c150e0b9e7278f839
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PRSS35 IGSF10 ABCA13 HSPA2

6.64e-051387042e46d546ad962aa0fde5b1c18c2a5370a4424e9f
ToppCellBasal_cells-IPF_04|World / lung cells shred on cell class, cell subclass, sample id

ABCA13 CAMK2B APOB HSPA2

1.26e-04163704679e25e5548d157d49a73057a3b5617dccda260f
ToppCellClub_cells-Donor_05|World / lung cells shred on cell class, cell subclass, sample id

CELSR1 KIF1A NT5E APOB

1.29e-041647044e25e6362ef793b08de2f4d1dccb6b1fc9c072a5
ToppCell356C-Myeloid-Macrophage-SPP1+_Macrophage|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

HDAC11 ZNF559 GTF3C4 CNN3

1.29e-04164704d6806deabf5f5c355934387be2baae125ac33fb8
ToppCellsaliva-Severe-critical_progression_d12-22_with-steroid-Myeloid-Macrophage|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

HSPB9 TNS1 DNAH7 HSPA6

1.32e-04165704436ce4bc75e1ba4351c439ccad19f84ad5bcb92f
ToppCellsaliva-Severe-critical_progression_d12-22_with-steroid-Myeloid-Macrophage-macrophage,_alveolar|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

HSPB9 TNS1 DNAH7 HSPA6

1.32e-04165704242bdb7654f415391fb8e9bdc06412c7eee9c97e
ToppCell343B-Myeloid-Macrophage-FABP4+_Macrophage|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

NT5E CAMK2B PCP2 TNS1

1.36e-04166704f62db9d9b6c9dd8f2afcaea0fc5f8c69f50205b2
ToppCellfacs-Lung-18m-Hematologic-lymphocytic-CD8-positive,_alpha-beta_T_cell-CD8-positive,_alpha-beta_T_cell_l21|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CELSR1 NT5E CHD3 PRKCQ

1.42e-041687046c758eb120faf06ff72d157b495e399191c79ec9
ToppCellfacs-Lung-18m-Hematologic-lymphocytic-CD4-positive,_alpha-beta_T_cell-CD4-positive,_alpha-beta_T_cell_l21|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PCED1B NT5E GAN PRKCQ

1.49e-04170704bda900c836e0f2c1d7b442beb50b672d025b2420
ToppCellMS-CD8-proli_CD4|MS / Condition, Cell_class and T cell subcluster

CTNNAL1 RPGRIP1L ELF4 GTF3C4

1.55e-041727040b6dd257110b3f17fa71ab18a165b091a9d5ae9a
ToppCellfacs-Spleen-nan-24m-Lymphocytic-Cd3e_T_cell|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CELSR1 NT5E CHD3 PRKCQ

1.59e-04173704f2eeff86e7dc7f4e3c36f775777d56685d7096cf
ToppCellPND28-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CABP1 CTNNAL1 PCP2 PRKCQ

1.59e-0417370403b50b2376d353748a32bf14a9fc8341ea61dbca
ToppCellPND28-Endothelial-Endothelial_lymphatic|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CABP1 CTNNAL1 PCP2 PRKCQ

1.59e-041737042978c744d3c8dcaa2b9bb225abf846f82e8f9176
ToppCellPND28-Endothelial-Endothelial_lymphatic-Lymphatic_EC|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CABP1 CTNNAL1 PCP2 PRKCQ

1.59e-0417370412da47b90aecedaa31764ff7ddb853ee39123e9d
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Degenerative_Medullary_Thick_Ascending_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CABP1 PRKCQ GNAS HSPA2

1.59e-041737047a3115e7cf7e2f345192cde0656a7f0193594a5f
ToppCellPND28-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CABP1 CTNNAL1 PCP2 PRKCQ

1.59e-0417370423d4a315a0ad5c6fc77bcfc18b6c1ff55be99e8f
ToppCellfacs-Spleen-nan-24m-Lymphocytic-CD4-positive,_alpha-beta_T_cell|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CELSR1 NT5E CHD3 PRKCQ

1.62e-04174704096bc6f1889f2bbadfe1e1a3eb6ae569aaa2ee7d
ToppCellfacs-Limb_Muscle-ForelimbandHindlimb-3m-Lymphocytic-T_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCED1B CELSR1 NT5E CPM

1.73e-041777049d2d70d53b919fed3328812889a55e5e1a0759de
ToppCelldroplet-Lung-nan-18m-Lymphocytic-CD4-positive,_alpha-beta_T_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CELSR1 NT5E CHD3 PRKCQ

1.77e-04178704730720598c530d2a413ef2a3354ecc66ebb4698c
ToppCelldroplet-Lung-nan-18m-Lymphocytic-CD4+_T|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CELSR1 NT5E CHD3 PRKCQ

1.77e-041787048fab75295780e18ee7b4556d66b641c20de10dd2
ToppCelldroplet-Lung-18m-Hematologic-lymphocytic-CD4-positive,_alpha-beta_T_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CELSR1 NT5E CHD3 PRKCQ

1.85e-0418070403e3067ee313e8c40b702b9bc9981f9859d045a2
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Degenerative_Medullary_Thick_Ascending_Limb_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CABP1 HSPB9 GNAS HSPA2

1.85e-0418070440f79b4455dbd1c2720dc32d9d77c70f835cecb3
ToppCelldroplet-Kidney-nan-3m-Mesenchymal-podocyte|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IGSF10 CAMK2B PCDHB14 SYN1

1.89e-041817040b1e7335648823b1d83bdfa878ccd44efe7bba9a
ToppCellfacs-Spleen-nan-18m-Lymphocytic-CD4-positive,_alpha-beta_T_cell|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CELSR1 NT5E CHD3 PRKCQ

1.93e-04182704fbe5bdd642b86010dbef0a567b25c69c7335688f
ToppCelldroplet-Marrow-nan-3m-Hematologic-nan|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TPR CHD3 PRKCQ TRIP11

1.93e-04182704e78ba2c5cae480c16a596ce7c3bf2d480becacf4
ToppCellfacs-Spleen-nan-18m-Lymphocytic-Cd3e_T_cell|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CELSR1 NT5E CHD3 PRKCQ

1.93e-04182704da3e9093cba791c7c282eb044656046252a32789
ToppCelldroplet-Marrow-nan-3m-Hematologic|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TPR CHD3 PRKCQ TRIP11

1.93e-041827041710eab3037a87609d21838be2d2d29c3bc36651
ToppCellBasal|World / shred by cell class for mouse tongue

CELSR1 CTNNAL1 ANTXR1 TNS1

1.97e-04183704c6729a207526ff4aa48176207b9353176f631fea
ToppCellfacs-SCAT-Fat-3m-Lymphocytic-T_cell|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCED1B CELSR1 PRKCQ CPM

2.01e-04184704cdacb61878e0824b8416bf365d89965797208359
ToppCellCOPD-Stromal-Pericyte|COPD / Disease state, Lineage and Cell class

LZTS1 TNS1 HSPA2 CNN3

2.01e-04184704a56264a22dfc2d3672b20134ab7c3c7c23da5ae1
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ZHX3 TRPM7 PRKCQ CPM

2.05e-0418570403f64a7132b13a01ba47187e0e15c13ac88f7cb2
ToppCellMild_COVID-19-Epithelial-AT1/AT2|Mild_COVID-19 / Disease group,lineage and cell class （2021.01.30）

CAMK2B SCNN1A HSPA2 CNN3

2.05e-04185704c55fdba1e3818ec0404d7ab473bf18dd25f2bb0a
ToppCelldroplet-Spleen-nan-3m|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TPR CHD3 TRIP11 CNN3

2.10e-0418670426f1e9930adf2fe4af0819e56f69915bd8330e4a
ToppCellLPS-antiTNF-Epithelial_alveolar-AT_1-Differentiating_AT2|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CELSR1 PCP2 SCNN1A PRKCQ

2.14e-0418770458d48128547ee3513d0bf7f78e61b76b1c472ca9
ToppCellwk_08-11-Mesenchymal-Myofibro_&_SMC-Vascular_SMC_1|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

PRSS35 ANTXR1 KCNS3 HSPA2

2.14e-041877041aebf6fab40b96f2f5feb77a302bb805838fccf3
ToppCell11.5-Airway-Mesenchymal-Pericyte|Airway / Age, Tissue, Lineage and Cell class

PRSS35 LZTS1 KCNS3 HSPA2

2.18e-04188704916971d8660fd20f616346953874e89d2cd13e88
ToppCelldroplet-Kidney-KIDNEY-30m-Epithelial-kidney_distal_convoluted_tubule_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRPM7 ABCA13 SCNN1A ANTXR1

2.18e-04188704d2d2b6c49448da24f457cedcd213f68841834a99
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CABP1 TRPM7 SCNN1A PRKCQ

2.27e-04190704b94df372bc08de11585b2467dba8c8fffff5cd92
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ABCA13 SCNN1A PRKCQ DNAH7

2.27e-041907043fc9e18c7441c0ae8cda65753cc42d0520f4e116
ToppCellNS-moderate-d_16-33-Epithelial-FOXN4+|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

RPGRIP1L NT5E CHAF1A DNAH7

2.27e-04190704250ca4a605c1cccd77d23383e4fe6f91cf3609ba
ToppCellFetal_29-31_weeks-Mesenchymal-vascular_smooth_muscle_cell|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

PRSS35 CABP1 LZTS1 ANTXR1

2.27e-04190704d6b3a92119b210974a32af3fe9875d60eb02761e
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CABP1 ZHX3 PRKCQ CPM

2.27e-04190704cc17ab84a9328124f146951c06be3eff9650d9fd
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TPR APOB TRIP11 BRWD3

2.32e-0419170460c986d2dcbc19d9338c03da6cb5e1d92fd48f8e
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Degenerative_Medullary_Thick_Ascending_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CABP1 SCNN1A PRKCQ HSPA2

2.32e-04191704f631749ef1f2270133664cf5eb4cf545a8482bd3
ToppCelldroplet-Kidney-KIDNEY-30m-Epithelial-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CTNNAL1 ABCA13 SCNN1A TMEM151A

2.32e-041917045a5b5402a077b3189ca156f2bac5f47ad780aebf
ToppCelldroplet-Kidney-KIDNEY-30m-Epithelial-Epcam____thick_ascending_tube_S_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CTNNAL1 ABCA13 SCNN1A TMEM151A

2.32e-0419170478bcce497920cc5b3bef083eab50deb1cc82cd2e
ToppCellsevere-Lymphocytic-CD4_T_cells_3|Lymphocytic / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

PCED1B TPR TPP1 PRKCQ

2.32e-04191704afff6bfae9a2f1e17d2731315e7fe63c4601679f
ToppCellMesenchymal-vascular_smooth_muscle_cell|World / Lineage, Cell type, age group and donor

PRSS35 CABP1 LZTS1 ANTXR1

2.32e-04191704fd89fbc62aa1c73e0f659991e3bd726a0c97bd68
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TPR APOB TRIP11 BRWD3

2.32e-0419170409db184cb90fe282a14474d7217068c58092c6f8
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL-30m|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TPR APOB TRIP11 BRWD3

2.32e-04191704973117730d6ba5f127e7a0bfabfd0ff2ca7ac131
ToppCellPCW_07-8.5-Epithelial-Epithelial_neuroendo-epi_NE_progenitor_(7)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

CELSR1 SCNN1A CPM DNAH7

2.36e-04192704b99f8236ef4ccdc75c02abea381cae6453205f6f
ToppCelldroplet-Kidney-nan-18m-Epithelial-Epcam_____kidney_distal_convoluted_tubule_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRPM7 ABCA13 SCNN1A ANTXR1

2.36e-041927046fb56d062c35617b18b927704bf5fba894faed81
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CABP1 TRPM7 SCNN1A HSPA2

2.36e-0419270432e4a180037e516c5cc798cd9dada9385e0f43ae
ToppCelldroplet-Bladder-nan-3m|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRSS35 IGSF10 ANTXR1 GNAS

2.41e-04193704e55f79bad6888b84b0ad5fccded498b170e3c6dc
ToppCellNS-moderate-d_0-4|moderate / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

IGSF10 CELSR1 ABCA13 DNAH7

2.41e-04193704ea345d34440b25f65358a53dc72831998d1c3620
ToppCellfacs-Marrow-B-cells-3m|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DDX54 CPM HSPA2 CNN3

2.41e-0419370424c34c6635eb7fc2878282803c421b64320e77d8
ToppCellwk_15-18-Mesenchymal-Myofibro_&_SMC-Vascular_SMC_2|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

CABP1 ANTXR1 KCNS3 HSPA2

2.41e-04193704360079cbaa18b74e4a48c5de40844faca076e1a6
ToppCellwk_15-18-Epithelial-Airway_epithelial_progenitor-epi-airway_progenitor_early|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

CELSR1 SCNN1A CPM HSPA6

2.41e-04193704de569c6e507856fd3ac2311f246cb597074ed30c
ToppCelldroplet-Kidney-nan-18m-Epithelial-kidney_distal_convoluted_tubule_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRPM7 ABCA13 SCNN1A ANTXR1

2.41e-04193704fa8bcf2a5ab7b08fae98a1466a936995142b4309
ToppCellmoderate-Epithelial-FOXN4+|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

RPGRIP1L ABCA13 NT5E DNAH7

2.46e-041947045dffa578149104dda33774361e9e77b227b5f1ce
ToppCellTCGA-Adrenal-Primary_Tumor-Pheochromocytoma|TCGA-Adrenal / Sample_Type by Project: Shred V9

KIF1A CAMK2B SYN1 TMEM151A

2.46e-04194704b6488bc3a8905e926ad298332963e1bbaf010046
ToppCellTCGA-Adrenal-Primary_Tumor-Pheochromocytoma-Pheochromocytoma|TCGA-Adrenal / Sample_Type by Project: Shred V9

KIF1A CAMK2B SYN1 TMEM151A

2.46e-041947041e1f4139ad584f493d75a9b7f1568eca4653c5a2
ToppCellfacs-Marrow-B-cells-3m-Lymphocytic|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DDX54 CPM HSPA2 CNN3

2.46e-041947047ee8ac172c2dee7df7dc4eb222e0985a0089bda8
ToppCellfacs-Diaphragm-Limb_Muscle-3m-Mesenchymal|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZHX3 MAT2A GNAS CNN3

2.51e-041957044d63e0dca30ae57960459d2fbcba09122273e37b
ToppCell18-Distal-Mesenchymal-Pericyte|Distal / Age, Tissue, Lineage and Cell class

CABP1 ANTXR1 KCNS3 HSPA2

2.51e-04195704e0ee7905499ee1a1ca7b1184e2713028cf156985
ToppCellfacs-Diaphragm-Limb_Muscle-3m-Mesenchymal-nan|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZHX3 MAT2A GNAS CNN3

2.51e-04195704661af601a3561fe3aacf2444ad7b8927fa88b48a
ToppCell11.5-Distal-Epithelial-Neuroendocrine|Distal / Age, Tissue, Lineage and Cell class

KIF1A CAMK2B SCNN1A TMEM151A

2.51e-04195704eda6ebe52c48bd6a9044886e75f584f46c2556e7
ToppCelldroplet-Tongue-TONGUE-1m-Epithelial-basal_cell|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANTXR1 CHD3 GNAS TNS1

2.51e-04195704eaadc79f53b1cb208c6f7999925f318e1378197f
ToppCellwk_15-18-Mesenchymal-Myofibro_&_SMC-Vascular_SMC_1|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

PRSS35 ANTXR1 KCNS3 HSPA2

2.56e-0419670440cae477b3906623d1f2a4c630279e710499ce80
ToppCellfacs-Diaphragm-Limb_Muscle-3m-Mesenchymal-skeletal_muscle_satellite_cell|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZHX3 MAT2A GNAS CNN3

2.56e-0419670497ac47daf5bb07fa5dda3976e1ae402750f959b5
ToppCellNS-moderate-d_07-13-Epithelial-Secretory|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

ABCA13 SCNN1A CYP4F12 CNN3

2.56e-0419670447930de6b47b7bf22d8dae8b7419a9cd1d22f0ea
ToppCelldroplet-Tongue-TONGUE-1m-Epithelial-basal_cell_of_epidermis|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MAT2A ANTXR1 CHD3 TNS1

2.56e-04196704d4df86ce289835e76763213641989fde77935a16
ToppCellTracheal-10x3prime_v2-Stromal-Fibroblastic-Fibro_immune_recruiting|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

ZHX3 LZTS1 NT5E PFAS

2.61e-041977044edf043e8f586fd375f56485841fe992a18bf853
ToppCell(2)_Fibroblasts-(22)_Fibro-3|(2)_Fibroblasts / Cell class and subclass of bone marrow stroma cells in homeostatis

KIF1A LZTS1 BBS9 CNN3

2.61e-04197704d9021bab82403e566ec10f78acb227c0f80b88fe
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PRSS35 CABP1 SCNN1A HSPA2

2.61e-041977044ea3f57cd88b8a6bb7cb4b9e3545c0fa8f331886
ToppCelldistal-Hematologic-IGSF21+_Dendritic|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

CPM HSPA6 HSPA7 NLRP3

2.61e-04197704a357ee2ba9100dfaeba9ecae8138a2776bb54b0b
ToppCellwk_20-22-Mesenchymal-Myofibro_&_SMC-Pericyte|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

LZTS1 KCNS3 TNS1 HSPA2

2.61e-0419770444cd1ece3633a31e8c9b667cd3cbc2749c06f478
ToppCellCOVID-19-Epithelial|COVID-19 / Condition, Lineage and Cell class

ABCA13 SCNN1A DNAH7 CNN3

2.61e-0419770418fd7344628a87d5c7ef5efb66e260a4136245bf
ToppCell3'-Pediatric_IBD-SmallIntestine-Mesenchymal-Pericytes-Pericyte|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LZTS1 KCNS3 TNS1 CNN3

2.61e-04197704452be45f4aac8459dd860493171f5f715368d663
ToppCellControl_saline-Epithelial_alveolar-AT_1-Differentiating_AT1|Control_saline / Treatment groups by lineage, cell group, cell type

PRSS35 CELSR1 SCNN1A CPM

2.66e-0419870485f424cd9bb3117c9e322031024aabb87696ce47
ToppCelldistal-Hematologic-IGSF21+_Dendritic-2|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

CPM HSPA6 HSPA7 NLRP3

2.66e-04198704323b4e6c31e18227546bb30566c1d872fda45e36
ToppCellBL-critical-LOC-Epithelial-Secretory_LYPD2|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

ABCA13 SCNN1A CYP4F12 CNN3

2.66e-04198704484d16aaa601a1e11b871b0475dd01a2de1a29ce
DrugMercuric Chloride

TPR PTPN12 NT5E MAT2A TPP1 CD2BP2 SCNN1A ANTXR1 PSMC6 APOB CHD3 HSPA6 HSPA7 PGM1 NLRP3

1.80e-0611557015ctd:D008627
DrugCyanocobalamin [68-19-9]; Down 200; 3uM; PC3; HT_HG-U133A

CELSR1 TPP1 INPP5K ELF4 CHD3 BBS9 TRIP11

2.23e-061947074572_DN
DrugFlurandrenolide [1524-88-5]; Down 200; 9.2uM; MCF7; HT_HG-U133A

HDAC11 RPGRIP1L KIF1A GLRA1 GAN ELF4 TRIP11

2.47e-061977074702_DN
Drugisodonin

NT5E NLRP3

9.32e-062702CID000073075
Diseaseneuroblastoma (is_marker_for)

CHAF1A SCNN1A

1.54e-048702DOID:769 (is_marker_for)
DiseasePseudohypoaldosteronism

SCNN1A GNAS

2.47e-0410702C0033805
DiseaseHyperpotassemia and Hypertension, Familial

SCNN1A GNAS

2.47e-0410702C2713447
DiseasePseudohypoaldosteronism, Type I

SCNN1A GNAS

2.47e-0410702C0268436
DiseasePseudohypoaldosteronism, Type I, Autosomal Recessive

SCNN1A GNAS

2.47e-0410702C1449843
DiseasePseudohypoaldosteronism, Type II

SCNN1A GNAS

2.47e-0410702C1449844
DiseasePseudohypoaldosteronism, Type I, Autosomal Dominant

SCNN1A GNAS

2.47e-0410702C1449842
DiseaseMacrocephaly

CHD3 BRWD3

3.01e-0411702C0221355
DiseaseSclerocystic Ovaries

DDX54 SCNN1A GNAS TMEM151A

3.88e-04144704C1136382
DiseasePolycystic Ovary Syndrome

DDX54 SCNN1A GNAS TMEM151A

3.88e-04144704C0032460
Diseasebilirubin measurement

ZHX3 SLCO1B3 NCK1 APOB CHD3 NLRP3

6.38e-04442706EFO_0004570
DiseaseIntellectual Disability

UBA5 CAMK2B TPP1 CHD3 GNAS BRWD3

6.76e-04447706C3714756
Diseasecorneal resistance factor

PCED1B ZHX3 HDAC11 ANTXR1 BBS9 TNS1

7.08e-04451706EFO_0010067
Diseaselow affinity immunoglobulin gamma Fc region receptor II-a measurement

HSPA6 HSPA7

7.37e-0417702EFO_0021969
Diseaseserum alanine aminotransferase measurement

TRPM7 LZTS1 GSDMD SLCO1B3 NCK1 APOB HSPA6 NLRP3

1.03e-03869708EFO_0004735
Diseaselow affinity immunoglobulin gamma Fc region receptor II-b measurement

HSPA6 HSPA7

1.61e-0325702EFO_0021970
DiseaseMental Retardation, X-Linked

BRWD3 DIPK2B

2.16e-0329702C1136249
DiseaseCiliopathies

RPGRIP1L SCNN1A BBS9

2.30e-03110703C4277690

Protein segments in the cluster

PeptideGeneStartEntry
GDTYMHEGFERASEQ

ANTXR1

116

Q9H6X2
HFYDAMDGQIQGSVE

GSDMD

81

P57764
DAHQGNGHERDFMDD

HDAC11

181

Q96DB2
GMGHSLEALRNQFEE

ABCA13

371

Q86UQ4
DEMFNHAGAGRFRFL

ABCA13

3406

Q86UQ4
QMGDELIYFRQGHEA

BRWD3

941

Q6RI45
GDMRHFFQLDLLNGD

CELSR1

1041

Q9NYQ6
RRHDGQIGAEDMDGF

CHAF1A

886

Q13111
MFGVFNNGHLFIRDA

DIPK2B

296

Q9H7Y0
NLGGHVDFDDFVELM

CABP1

276

Q9NZU7
HDFGAAFDGDGDRNM

PGM1

281

P36871
FFNLLSHVQGDRMEG

PCP2

26

Q8IVA1
MNEFETEGFFALHQR

PRKCQ

131

Q04759
LREERQGHDQMSSGF

LZTS1

511

Q9Y250
QAEMALNERGHEGDF

NCK1

291

P16333
GVAHVDLADMFQEGR

RPGRIP1L

1256

Q68CZ1
LDCGMHMGFNDDRRF

INTS11

31

Q5TA45
IFEFASNGMDDDIHQ

ELF4

11

Q99607
DNDHARDGFQMKLDA

HSPB9

46

Q9BQS6
MNGQLNGFHEAFIEE

MAT2A

1

P31153
LGGDRMEDQFAALHE

DDX54

201

Q8TDD1
AGDTHLGGEDFDNRM

HSPA2

226

P54652
LGGEDFDNRMVSHLA

HSPA2

231

P54652
FEQDELVDGGQRGHM

PCED1B

56

Q96HM7
MVFGEFFHRPGQDEE

KCNS3

1

Q9BQ31
GFRRGDFIHVMDNSD

GRB2

176

P62993
DDDQVNVMGFHFLGG

BBS9

571

Q3SYG4
GGEDFDNRLVNHFME

HSPA7

231

P48741
EDGFEMQFGVNHLGH

RDH13

136

Q8NBN7
VHDTGRNMGEIENFR

PCDHB14

776

Q9Y5E9
RHAIGNNEYGEMEAE

PDP2

476

Q9P2J9
NLQEEMEEGHFDADG

CD2BP2

91

O95400
MEAHVGINGEANLDF

APOB

3111

P04114
TEFQDSDQMGRGREH

IGSF10

901

Q6WRI0
QFGNEMVEFAHLSGD

CTNNAL1

196

Q9UBT7
AALDFNYHRQEGMEA

CPM

16

P14384
RFMFNIADGGFTELH

CHD3

1706

Q12873
NEARHNFGIVEIDGM

GAN

361

Q9H2C0
GDMNFRIEDFGLHFV

INPP5K

191

Q9BT40
NGFLMERRENFLHGD

GARRE1

616

O15063
EDIRAEADTFMFGGH

CYP4F8

316

P98187
EDIRAEADTFMFGGH

CYP4F12

316

Q9HCS2
HELFQRLDFDNDGMV

DNAH7

2246

Q8WXX0
KVNFHMFDVGGQRDE

GNAS

216

P63092
MFQRDRDNAIYGEHG

C1QTNF8

221

P60827
GGEDFDNRLVNHFME

HSPA6

231

P17066
AGARGFFQARHLEMD

FAM83H

391

Q6ZRV2
QDEPAFMDDGGFNLR

SCNN1A

356

P37088
DIGEEMLQHAFEGYN

KIF1A

76

Q12756
MDGFDELQGAFDEHI

NLRP3

301

Q96P20
HANGGFSVDMEVLRN

SYN1

156

P17600
EALGNLVEGMDFHRF

CAMK2B

571

Q13554
MLNLFQEDEAGEGRF

GLRA1

356

P23415
NFHMFDVGGQRDERR

GNAS

861

Q5JWF2
DHNGEDNFARDFMRL

PTPN12

21

Q05209
NEGLDDYLEAREGMH

TMEM151A

246

Q8N4L1
DAMALGNHEFDNGVE

NT5E

111

P21589
HDIFEANDLFENGNM

CNN3

101

Q15417
GMQQHFFDDEDRTVP

TPR

2121

P12270
NFQHFMDRISNGGLE

UBA5

156

Q9GZZ9
MIHFSGFDNDRADQL

PRSS35

306

Q8N3Z0
EGSNGDREMADAFHL

PFAS

1071

O15067
MDEANLEFLNNGEHF

SLCO1B3

666

Q9NPD5
NFSGHRDDGMEEVVG

TNS1

341

Q9HBL0
GNLGDFAEFQRRHSM

GTF3C4

231

Q9UKN8
AEDQDGLSEMQEGHF

ZNF264

126

O43296
EMEQLFHDDQGGVTR

TRIP11

1816

Q15643
GMFAIRADHDFVVQE

PSMC6

351

P62333
MERNHFGEELFDFNQ

ZNF559

81

Q9BR84
GEMEVREGDHSFING

ZHX3

221

Q9H4I2
EFGAFVGHRDSMDLQ

TRPM7

1436

Q96QT4
REFSGHQGQINDMAF

WDR36

616

Q8NI36
HDSDLAQFMRLFGGN

TPP1

236

O14773