Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	1-phosphatidylinositol-4-phosphate 5-kinase activity	PIP5K1C PIP5K1A PIP5K1B	4.73e-05	9	168	3	GO:0016308
GeneOntologyMolecularFunction	mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity	MAN2A2 MAN2A1	7.04e-05	2	168	2	GO:0004572
GeneOntologyMolecularFunction	adenylosuccinate synthase activity	ADSS2 ADSS1	7.04e-05	2	168	2	GO:0004019
GeneOntologyMolecularFunction	1-phosphatidylinositol-3-phosphate 5-kinase activity	PIP5K1A PIP5K1B	2.10e-04	3	168	2	GO:0000285
GeneOntologyMolecularFunction	1-phosphatidylinositol-5-kinase activity	PIP5K1A PIP5K1B	2.10e-04	3	168	2	GO:0052810
GeneOntologyMolecularFunction	complement component C4b binding	CR1 MASP2	2.10e-04	3	168	2	GO:0001855
GeneOntologyMolecularFunction	L-glutamate uniporter activity	SLC17A8 SLC17A6	2.10e-04	3	168	2	GO:0140788
GeneOntologyMolecularFunction	membrane potential driven uniporter activity	SLC17A8 SLC17A6	6.92e-04	5	168	2	GO:0022810
GeneOntologyMolecularFunction	neurotransmitter transmembrane transporter activity	GABRQ SLC17A8 SLC17A6	6.96e-04	21	168	3	GO:0005326
GeneOntologyCellularComponent	cluster of actin-based cell projections	FLII FLNA CORO2A CDHR2 ADGRV1 KCNK1 PCDH15 PRKCB SLC6A14	7.57e-05	223	166	9	GO:0098862
GeneOntologyCellularComponent	pericellular basket	SLC17A8 SLC17A6	1.87e-04	3	166	2	GO:1990030
GeneOntologyCellularComponent	brush border	FLII FLNA CORO2A CDHR2 KCNK1 PRKCB SLC6A14	2.16e-04	152	166	7	GO:0005903
Domain	PInositol-4-P-5-kinase	PIP5K1C PIP5K1A PIP5K1B	2.44e-05	7	168	3	IPR023610
Domain	PIPKc	PIP5K1C PIP5K1A PIP5K1B	3.87e-05	8	168	3	SM00330
Domain	-	PIP5K1C PIP5K1A PIP5K1B	3.87e-05	8	168	3	3.30.800.10
Domain	PIP5K	PIP5K1C PIP5K1A PIP5K1B	3.87e-05	8	168	3	PF01504
Domain	PIPK	PIP5K1C PIP5K1A PIP5K1B	3.87e-05	8	168	3	PS51455
Domain	PInositol-4-P-5-kinase_N	PIP5K1C PIP5K1A PIP5K1B	3.87e-05	8	168	3	IPR027484
Domain	PInositol-4-P-5-kinase_C	PIP5K1C PIP5K1A PIP5K1B	3.87e-05	8	168	3	IPR027483
Domain	-	PIP5K1C PIP5K1A PIP5K1B	3.87e-05	8	168	3	3.30.810.10
Domain	PInositol-4-P-5-kinase_core	PIP5K1C PIP5K1A PIP5K1B	3.87e-05	8	168	3	IPR002498
Domain	Adenylsucc_synt	ADSS2 ADSS1	8.04e-05	2	168	2	SM00788
Domain	ADENYLOSUCCIN_SYN_2	ADSS2 ADSS1	8.04e-05	2	168	2	PS00513
Domain	Adenylosuccin_syn_GTP-bd	ADSS2 ADSS1	8.04e-05	2	168	2	IPR018220
Domain	Adenylsucc_synt	ADSS2 ADSS1	8.04e-05	2	168	2	PF00709
Domain	Adenylosuccin_syn_Lys_AS	ADSS2 ADSS1	8.04e-05	2	168	2	IPR033128
Domain	Adenylosuccinate_synthetase	ADSS2 ADSS1	8.04e-05	2	168	2	IPR001114
Domain	ADENYLOSUCCIN_SYN_1	ADSS2 ADSS1	8.04e-05	2	168	2	PS01266
Domain	Pkinase_C	RPS6KA1 CDC42BPB SGK3 PRKCB	3.31e-04	37	168	4	IPR017892
Domain	Metaxin_GST	FAXC MTX1	4.77e-04	4	168	2	IPR033468
Domain	GST_C_6	FAXC MTX1	4.77e-04	4	168	2	PF17171
Domain	Pkinase_C	RPS6KA1 CDC42BPB SGK3 PRKCB	5.42e-04	42	168	4	PF00433
Domain	Glyco_hydro_38_C	MAN2A2 MAN2A1	7.90e-04	5	168	2	IPR011682
Domain	Alpha-mann_mid	MAN2A2 MAN2A1	7.90e-04	5	168	2	PF09261
Domain	Glyco_hydro_57/38_cen	MAN2A2 MAN2A1	7.90e-04	5	168	2	IPR028995
Domain	Glyco_hydro_38	MAN2A2 MAN2A1	7.90e-04	5	168	2	PF01074
Domain	-	MAN2A2 MAN2A1	7.90e-04	5	168	2	1.20.1270.50
Domain	-	MAN2A2 MAN2A1	7.90e-04	5	168	2	3.20.110.10
Domain	Alpha-mann_mid	MAN2A2 MAN2A1	7.90e-04	5	168	2	SM00872
Domain	Glyco_hydro_38_N	MAN2A2 MAN2A1	7.90e-04	5	168	2	IPR000602
Domain	Glyco_hydro_38/57_N	MAN2A2 MAN2A1	7.90e-04	5	168	2	IPR027291
Domain	Glyco_hydro_38_cen	MAN2A2 MAN2A1	7.90e-04	5	168	2	IPR015341
Domain	Glyco_hydro_38C	MAN2A2 MAN2A1	7.90e-04	5	168	2	PF07748
Domain	DAG/PE-bd	CDC42BPB PRKD3 PRKCB	8.44e-04	21	168	3	IPR020454
Domain	BRK	CHD8 SMARCA4	1.18e-03	6	168	2	SM00592
Domain	BRK_domain	CHD8 SMARCA4	1.18e-03	6	168	2	IPR006576
Domain	TFR_dimer	NAALAD2 FOLH1	1.18e-03	6	168	2	PF04253
Domain	BRK	CHD8 SMARCA4	1.18e-03	6	168	2	PF07533
Domain	-	NAALAD2 FOLH1	1.18e-03	6	168	2	1.20.930.40
Domain	MFS_dom	MFSD11 FLVCR2 SLC15A3 SLC17A8 SV2C SLC17A6	1.35e-03	134	168	6	IPR020846
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	ATMIN FLII FLNA SYNRG LZTR1 MAN2A2 AOC2 MYOM3 CHD8 RELB HUWE1 PIP5K1C BCR CDC42BPB REXO1 TBC1D9 JUN PLEKHM2 DOT1L PLXNA1 GAREM1	1.10e-07	1105	169	21	35748872
Pubmed	Activation of type I phosphatidylinositol 4-phosphate 5-kinase isoforms by the Rho GTPases, RhoA, Rac1, and Cdc42.	PIP5K1C PIP5K1A PIP5K1B	1.13e-07	3	169	3	14681219
Pubmed	PIP5KIβ selectively modulates apical endocytosis in polarized renal epithelial cells.	PIP5K1C PIP5K1A PIP5K1B	1.13e-07	3	169	3	23342003
Pubmed	Phosphatidylinositol-4-phosphate 5-kinase isoforms exhibit acyl chain selectivity for both substrate and lipid activator.	PIP5K1C PIP5K1A PIP5K1B	1.13e-07	3	169	3	22942276
Pubmed	Characterization of SARS-CoV-2 proteins reveals Orf6 pathogenicity, subcellular localization, host interactions and attenuation by Selinexor.	FLNA OGT ZMPSTE24 IPO8 FOLH1 LBR HUWE1 IVNS1ABP EEF2 EIF4B SMARCA4 NMT1 PLOD1	1.16e-07	408	169	13	33766124
Pubmed	Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.	FUT10 CORO2A RBBP4 RPS6KA1 PIP5K1C LRP1B CDC42BPB SGK3 KCNA3 KCNA4 ADSS2 SMARCA4 PIP5K1A PRKCB DNAH5 PLXNA1 ADSS1	1.17e-07	730	169	17	34857952
Pubmed	SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis.	FLNA OGT ZMPSTE24 IPO8 RBBP4 LBR HUWE1 TBC1D9 IVNS1ABP EEF2 EIF4B SMARCA4 QARS1 PLOD1 ILVBL IPO11	1.55e-07	657	169	16	36180527
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	FLII XRN2 OGT CORO2A FOLH1 ACO1 RIPPLY3 PSMD5 HUWE1 LRP1B CDC42BPB DDX27 SCYL2 EEF2 UBA7 TMEM168 NFE2L2 KCNJ6 SEC23IP SMARCA4 SPARCL1 QARS1	3.19e-07	1285	169	22	35914814
Pubmed	Loss of PIP5KIgamma, unlike other PIP5KI isoforms, impairs the integrity of the membrane cytoskeleton in murine megakaryocytes.	PIP5K1C PIP5K1A PIP5K1B	4.49e-07	4	169	3	18188447
Pubmed	Identification and characterization of a phosphoinositide phosphate kinase homolog.	PIP5K1C PIP5K1A PIP5K1B	4.49e-07	4	169	3	14701839
Pubmed	Type I phosphatidylinositol-4-phosphate 5-kinases. Cloning of the third isoform and deletion/substitution analysis of members of this novel lipid kinase family.	PIP5K1C PIP5K1A PIP5K1B	4.49e-07	4	169	3	9535851
Pubmed	BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.	FLNA XRN2 OGT RBBP4 DHX37 WRN HAT1 CHD8 LBR HUWE1 DDX27 RHEB EEF2 UBE2E1 FAM111A SMARCA4 PRKCB QARS1 PLOD1 ILVBL TOP2B IPO11	4.88e-07	1318	169	22	30463901
Pubmed	Tissue-Specific Regulation of the Wnt/β-Catenin Pathway by PAGE4 Inhibition of Tankyrase.	FLNA XRN2 OGT IPO8 LBR HUWE1 SCYL2 IVNS1ABP EEF2 EIF4B	5.61e-07	256	169	10	32698014
Pubmed	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.	FLNA XRN2 IPO8 RBBP4 HAT1 LBR HUWE1 SCYL2 USP5 EEF2 SEC23IP SMARCA4 QARS1 TOP2B IPO11	5.98e-07	638	169	15	33239621
Pubmed	Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.	FLNA COL6A2 GALC MAN2A2 MAN2A1 DSC2 HAT1 CHD8 LBR CR1 RHEB GGH PLA2R1 EEF2 UBA7 NDUFAF1 GVINP1 SMARCA4 PIP5K1A GNB2 PLOD1 PLXNA1 ILVBL	6.40e-07	1451	169	23	30550785
Pubmed	A high-throughput approach for measuring temporal changes in the interactome.	FLII FLNA OGT RBBP4 ACO1 RPS6KA1 HAT1 PSMD5 HUWE1 IVNS1ABP GGH CDAN1 USP5 GDA EEF2 ADSS2 EIF4B SEC23IP QARS1 KIF13A NMT1 PLOD1 IPO11	6.71e-07	1455	169	23	22863883
Pubmed	HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.	FLII FLNA IPO8 IRF2BP1 DHX37 BCR IVNS1ABP USP5 EIF4B SMARCA4 SV2C FGD5 GNAL KIF13A PLOD1 ILVBL	9.56e-07	754	169	16	35906200
Pubmed	The lipid kinase PIP5K1C regulates pain signaling and sensitization.	PIP5K1C PIP5K1A PIP5K1B	1.12e-06	5	169	3	24853942
Pubmed	The Tumor Suppressor CIC Directly Regulates MAPK Pathway Genes via Histone Deacetylation.	FLII FLNA XRN2 IRF2BP1 RBBP4 DHX37 CHD8 HUWE1 IVNS1ABP HOXA11 JUN EEF2 EIF4B SMARCA4	1.12e-06	583	169	14	29844126
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	FLNA XRN2 IPO8 IRF2BP1 CORO2A RBBP4 HAT1 RELB LBR HUWE1 SLC15A3 DDX27 GGH USP5 EEF2 ADSS2 GNB2 QARS1 PLOD1 ILVBL TOP2B IPO11	2.09e-06	1440	169	22	30833792
Pubmed	Branches of the B cell antigen receptor pathway are directed by protein conduits Bam32 and Carma1.	PIP5K1C PIP5K1A PIP5K1B	2.23e-06	6	169	3	14614850
Pubmed	Rac controls PIP5K localisation and PtdIns(4,5)P₂ synthesis, which modulates vinculin localisation and neurite dynamics.	PIP5K1C PIP5K1A PIP5K1B	2.23e-06	6	169	3	20841379
Pubmed	Smurf1 regulates lung cancer cell growth and migration through interaction with and ubiquitination of PIPKIγ.	PIP5K1C PIP5K1A PIP5K1B	2.23e-06	6	169	3	28581524
Pubmed	Large-scale proteomics and phosphoproteomics of urinary exosomes.	FLNA MAN2A1 ZMPSTE24 DSC2 CDHR2 ACO1 ADGRV1 HUWE1 ACY1 CR1 BCR CDC42BPB NT5C RHEB GGH EEF2 PLOD1 MASP2	2.54e-06	1016	169	18	19056867
Pubmed	Proteomic analysis identifies novel binding partners of BAP1.	OGT RBBP4 HAT1 HUWE1 CPS1 EEF2	2.69e-06	80	169	6	34591877
Pubmed	STING-Mediated IFI16 Degradation Negatively Controls Type I Interferon Production.	FLNA XRN2 IPO8 RBBP4 DHX37 IVNS1ABP JUN EEF2 EIF4B QARS1	3.72e-06	316	169	10	31665637
Pubmed	Localization of mRNAs for phosphatidylinositol phosphate kinases in the mouse brain during development.	PIP5K1C PIP5K1A PIP5K1B	3.89e-06	7	169	3	15018809
Pubmed	Btk-dependent regulation of phosphoinositide synthesis.	PIP5K1C PIP5K1A PIP5K1B	6.20e-06	8	169	3	15046600
Pubmed	Glycogen synthase kinase-3: properties, functions, and regulation.	SGK3 PRKD3 PRKCB	6.20e-06	8	169	3	11749387
Pubmed	Phosphatidylinositol-4-phosphate 5-kinases and phosphatidylinositol 4,5-bisphosphate synthesis in the brain.	PIP5K1C PIP5K1A PIP5K1B	6.20e-06	8	169	3	20622009
Pubmed	Histone methyltransferase DOT1L coordinates AR and MYC stability in prostate cancer.	FLII XRN2 FOLH1 RPS6KA1 HUWE1 ACY1 EEF2 DOT1L GNB2	6.34e-06	264	169	9	32814769
Pubmed	Human serum and glucocorticoid-inducible kinase-like kinase (SGKL) phosphorylates glycogen syntheses kinase 3 beta (GSK-3beta) at serine-9 through direct interaction.	SGK3 PRKD3 PRKCB	9.27e-06	9	169	3	12054501
Pubmed	Comparative phenotypic analysis of the two major splice isoforms of phosphatidylinositol phosphate kinase type Iγ in vivo.	PIP5K1C PIP5K1A PIP5K1B	9.27e-06	9	169	3	22976293
Pubmed	Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	KIAA1549 ALS2 CHD8 HUWE1 DNAH5 PCDH18	1.04e-05	101	169	6	10997877
Pubmed	Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.	GABRQ ADGRV1 CR1 BCR LRP1B PLA2R1	1.04e-05	101	169	6	23382219
Pubmed	Convergence of multiple signaling cascades at glycogen synthase kinase 3: Edg receptor-mediated phosphorylation and inactivation by lysophosphatidic acid through a protein kinase C-dependent intracellular pathway.	SGK3 PRKD3 PRKCB	1.32e-05	10	169	3	11884598
Pubmed	Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A.	SGK3 PRKD3 PRKCB	1.32e-05	10	169	3	11035810
Pubmed	Ribosomal protein L12 uses a distinct nuclear import pathway mediated by importin 11.	HUWE1 UBE2E1 IPO11	1.81e-05	11	169	3	11809816
Pubmed	In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.	FLNA MAN2A1 DSC2 CDHR2 FOLH1 ACO1 ACY1 CR1 NT5C ABCB4 GGH EEF2 ADSS2 GNAL GNB2 MUC4 MASP2	2.00e-05	1070	169	17	23533145
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	FLNA XRN2 RBBP4 EEF2 SMARCA4 KIF13A DNAH5 TOP2B	2.05e-05	234	169	8	36243803
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	FLII OGT CHD8 HUWE1 BCR CDC42BPB RHEB GDA EEF2 KCNA3 KCNA4 P2RX7 SEC23IP SMARCA4 PRKCB GNB2	2.07e-05	963	169	16	28671696
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	FLII FLNA XRN2 IPO8 RBBP4 DHX37 HAT1 LBR HUWE1 DDX27 IVNS1ABP EEF2 ADSS2 SEC23IP SMARCA4 FGD5 QARS1 DNAH5 PLXNA1 TOP2B	2.15e-05	1425	169	20	30948266
Pubmed	Antioxidants for Healthy Skin: The Emerging Role of Aryl Hydrocarbon Receptors and Nuclear Factor-Erythroid 2-Related Factor-2.	NFE2L2 AHR	2.35e-05	2	169	2	28273792
Pubmed	Protein kinase Cbeta isoform down-regulates the expression of MDR3 P-glycoprotein in human Chang liver cells.	ABCB4 PRKCB	2.35e-05	2	169	2	16854530
Pubmed	PI4P5-kinase Ialpha is required for efficient HIV-1 entry and infection of T cells.	PIP5K1A PIP5K1B	2.35e-05	2	169	2	18981107
Pubmed	Early Transcriptomic Response to OxLDL in Human Retinal Pigment Epithelial Cells.	NFE2L2 AHR	2.35e-05	2	169	2	33233417
Pubmed	The beta- and gamma-isoforms of type I PIP5K regulate distinct stages of Ca2+ signaling in mast cells.	PIP5K1C PIP5K1B	2.35e-05	2	169	2	19549683
Pubmed	RABL2 Is Required for Hepatic Fatty Acid Homeostasis and Its Dysfunction Leads to Steatosis and a Diabetes-Like State.	RABL2B RABL2A	2.35e-05	2	169	2	27732084
Pubmed	A new cross-talk between the aryl hydrocarbon receptor and RelB, a member of the NF-kappaB family.	RELB AHR	2.35e-05	2	169	2	18955032
Pubmed	Introducing the "TCDD-inducible AhR-Nrf2 gene battery".	NFE2L2 AHR	2.35e-05	2	169	2	19474220
Pubmed	Air particulate matter induced oxidative stress and inflammation in cardiovascular disease and atherosclerosis: The role of Nrf2 and AhR-mediated pathways.	NFE2L2 AHR	2.35e-05	2	169	2	28189649
Pubmed	Acquisition of an immunosuppressive protumorigenic macrophage phenotype depending on c-Jun phosphorylation.	ABCB4 JUN	2.35e-05	2	169	2	25422452
Pubmed	HACE1 expression in heart failure patients might promote mitochondrial oxidative stress and ferroptosis by targeting NRF2.	NFE2L2 HACE1	2.35e-05	2	169	2	38070140
Pubmed	Involvement of RelB in aryl hydrocarbon receptor-mediated induction of chemokines.	RELB AHR	2.35e-05	2	169	2	17900530
Pubmed	Type Ialpha phosphatidylinositol-4-phosphate 5-kinase mediates Rac-dependent actin assembly.	PIP5K1A PIP5K1B	2.35e-05	2	169	2	10679324
Pubmed	Analysis of relative gene dosage and expression differences of the paralogs RABL2A and RABL2B by Pyrosequencing.	RABL2B RABL2A	2.35e-05	2	169	2	20138207
Pubmed	The aryl hydrocarbon receptor interacts with nuclear factor erythroid 2-related factor 2 to mediate induction of NAD(P)H:quinoneoxidoreductase 1 by 2,3,7,8-tetrachlorodibenzo-p-dioxin.	NFE2L2 AHR	2.35e-05	2	169	2	23800876
Pubmed	Molecular cloning and expression of cDNAs encoding human alpha-mannosidase II and a previously unrecognized alpha-mannosidase IIx isozyme.	MAN2A2 MAN2A1	2.35e-05	2	169	2	8524845
Pubmed	Cloning of cDNAs encoding two isoforms of 68-kDa type I phosphatidylinositol-4-phosphate 5-kinase.	PIP5K1A PIP5K1B	2.35e-05	2	169	2	8798574
Pubmed	Perillaldehyde Inhibits AHR Signaling and Activates NRF2 Antioxidant Pathway in Human Keratinocytes.	NFE2L2 AHR	2.35e-05	2	169	2	29643980
Pubmed	Up-regulation of human CYP2J2 in HepG2 cells by butylated hydroxyanisole is mediated by c-Jun and Nrf2.	JUN NFE2L2	2.35e-05	2	169	2	20194533
Pubmed	A central kinase domain of type I phosphatidylinositol phosphate kinases is sufficient to prime exocytosis: isoform specificity and its underlying mechanism.	PIP5K1A PIP5K1B	2.35e-05	2	169	2	15728183
Pubmed	HACE1, an E3 Ubiquitin Protein Ligase, Mitigates Kaposi's Sarcoma-Associated Herpesvirus Infection-Induced Oxidative Stress by Promoting Nrf2 Activity.	NFE2L2 HACE1	2.35e-05	2	169	2	30787155
Pubmed	Phosphatidylinositol phosphate kinases, a multifaceted family of signaling enzymes.	PIP5K1A PIP5K1B	2.35e-05	2	169	2	10187762
Pubmed	Type I phosphotidylinosotol 4-phosphate 5-kinase γ regulates osteoclasts in a bifunctional manner.	PIP5K1C PIP5K1A	2.35e-05	2	169	2	23300084
Pubmed	Homocitrullination Is a Novel Histone H1 Epigenetic Mark Dependent on Aryl Hydrocarbon Receptor Recruitment of Carbamoyl Phosphate Synthase 1.	CPS1 AHR	2.35e-05	2	169	2	26424795
Pubmed	High glucose-ROS conditions enhance the progression in cholangiocarcinoma via upregulation of MAN2A2 and CHD8.	MAN2A2 CHD8	2.35e-05	2	169	2	33141432
Pubmed	Cloning and characterization of the cDNA encoding human adenylosuccinate synthetase.	ADSS2 ADSS1	2.35e-05	2	169	2	1592113
Pubmed	PIP5K-driven PtdIns(4,5)P2 synthesis: regulation and cellular functions.	PIP5K1C PIP5K1A	2.35e-05	2	169	2	19889969
Pubmed	Regulation of the Hippocampal Network by VGLUT3-Positive CCK- GABAergic Basket Cells.	SLC17A8 SLC17A6	2.35e-05	2	169	2	28559797
Pubmed	Semaphorin-6D and Plexin-A1 Act in a Non-Cell-Autonomous Manner to Position and Target Retinal Ganglion Cell Axons.	SEMA6D PLXNA1	2.35e-05	2	169	2	37344233
Pubmed	Type I phosphatidylinositol-4-phosphate 5-kinases are distinct members of this novel lipid kinase family.	PIP5K1A PIP5K1B	2.35e-05	2	169	2	8955136
Pubmed	Essential and mutually compensatory roles of {alpha}-mannosidase II and {alpha}-mannosidase IIx in N-glycan processing in vivo in mice.	MAN2A2 MAN2A1	2.35e-05	2	169	2	16754854
Pubmed	Regulation of aryl hydrocarbon receptor-mediated transcription in human retinal pigmented epithelial cells.	AHR SMARCA4	2.35e-05	2	169	2	26966070
Pubmed	Functional involvement of the Brahma/SWI2-related gene 1 protein in cytochrome P4501A1 transcription mediated by the aryl hydrocarbon receptor complex.	AHR SMARCA4	2.35e-05	2	169	2	11805098
Pubmed	Molecular cloning and expression of a mouse muscle cDNA encoding adenylosuccinate synthetase.	ADSS2 ADSS1	2.35e-05	2	169	2	1939273
Pubmed	Induction of the RelB NF-kappaB subunit by the cytomegalovirus IE1 protein is mediated via Jun kinase and c-Jun/Fra-2 AP-1 complexes.	RELB JUN	2.35e-05	2	169	2	15596805
Pubmed	Coenzyme Q0 regulates NFκB/AP-1 activation and enhances Nrf2 stabilization in attenuation of LPS-induced inflammation and redox imbalance: Evidence from in vitro and in vivo studies.	JUN NFE2L2	2.35e-05	2	169	2	26548719
Pubmed	PI5KI-dependent signals are critical regulators of the cytolytic secretory pathway.	PIP5K1C PIP5K1A	2.35e-05	2	169	2	18073347
Pubmed	Membrane ruffling requires coordination between type Ialpha phosphatidylinositol phosphate kinase and Rac signaling.	PIP5K1C PIP5K1A	2.35e-05	2	169	2	12682053
Pubmed	RelB attenuates cigarette smoke extract-induced apoptosis in association with transcriptional regulation of the aryl hydrocarbon receptor.	RELB AHR	2.35e-05	2	169	2	28254546
Pubmed	RelB, a new partner of aryl hydrocarbon receptor-mediated transcription.	RELB AHR	2.35e-05	2	169	2	17823304
Pubmed	Gene expression of detoxifying enzymes in AhR and Nrf2 compound null mutant mouse.	NFE2L2 AHR	2.35e-05	2	169	2	12646173
Pubmed	A role for PtdIns(4,5)P2 and PIP5Kalpha in regulating stress-induced apoptosis.	PIP5K1A PIP5K1B	2.35e-05	2	169	2	16979564
Pubmed	Transcriptional regulation of NF-E2 p45-related factor (NRF2) expression by the aryl hydrocarbon receptor-xenobiotic response element signaling pathway: direct cross-talk between phase I and II drug-metabolizing enzymes.	NFE2L2 AHR	2.35e-05	2	169	2	15790560
Pubmed	Type I Phosphatidylinositol-4-Phosphate 5-Kinases α and γ Play a Key Role in Targeting HIV-1 Pr55Gag to the Plasma Membrane.	PIP5K1C PIP5K1A	2.35e-05	2	169	2	32376619
Pubmed	Essential and unique roles of PIP5K-gamma and -alpha in Fcgamma receptor-mediated phagocytosis.	PIP5K1C PIP5K1A	2.35e-05	2	169	2	19153220
Pubmed	Variations in the response of mouse isozymes of adenylosuccinate synthetase to inhibitors of physiological relevance.	ADSS2 ADSS1	2.35e-05	2	169	2	12482871
Pubmed	Loss of PIP5KIbeta demonstrates that PIP5KI isoform-specific PIP2 synthesis is required for IP3 formation.	PIP5K1A PIP5K1B	2.35e-05	2	169	2	18772378
Pubmed	Indoxyl sulphate-initiated activation of cardiac fibroblasts is modulated by aryl hydrocarbon receptor and nuclear factor-erythroid-2-related factor 2.	NFE2L2 AHR	2.35e-05	2	169	2	38506079
Pubmed	Targeting the phospholipase A2 receptor ameliorates premature aging phenotypes.	ZMPSTE24 PLA2R1	2.35e-05	2	169	2	30216637
Pubmed	Two novel human RAB genes with near identical sequence each map to a telomere-associated region: the subtelomeric region of 22q13.3 and the ancestral telomere band 2q13.	RABL2B RABL2A	2.35e-05	2	169	2	10444334
Pubmed	Phosphatidylinositol-4-phosphate-5-kinase alpha deficiency alters dynamics of glucose-stimulated insulin release to improve glucohomeostasis and decrease obesity in mice.	PIP5K1A PIP5K1B	2.35e-05	2	169	2	21270258
Pubmed	Inhibition of AP-1 and MAPK signaling and activation of Nrf2/ARE pathway by quercitrin.	JUN NFE2L2	2.35e-05	2	169	2	19956833
Pubmed	Variants in RABL2A causing male infertility and ciliopathy.	RABL2B RABL2A	2.35e-05	2	169	2	33075816
Pubmed	Enhancement of the gut barrier integrity by a microbial metabolite through the Nrf2 pathway.	NFE2L2 AHR	2.35e-05	2	169	2	30626868
Pubmed	Schwann cell O-GlcNAcylation promotes peripheral nerve remyelination via attenuation of the AP-1 transcription factor JUN.	OGT JUN	2.35e-05	2	169	2	30012597
Pubmed	Granule cell as a site of gene action in the weaver mouse cerebellum: evidence from heterozygous mutant chimeras.	LBR KCNJ6	2.35e-05	2	169	2	7119868
Pubmed	Angiotensin II stimulates KLF5 phosphorylation and its interaction with c-Jun leading to suppression of p21 expression in vascular smooth muscle cells.	JUN KLF5	2.35e-05	2	169	2	19628677
Pubmed	Molecular cloning and characterization of a novel muscle adenylosuccinate synthetase, AdSSL1, from human bone marrow stromal cells.	ADSS2 ADSS1	2.35e-05	2	169	2	15786719
GeneFamily	Cadherin related	CDHR2 CDHR3 PCDH15	1.44e-04	17	111	3	24
GeneFamily	Mannosidases alpha class 2	MAN2A2 MAN2A1	3.69e-04	5	111	2	1194
GeneFamily	RAB like GTPases	RABL2B RABL2A	3.69e-04	5	111	2	394
Coexpression	DIAZ_CHRONIC_MYELOGENOUS_LEUKEMIA_UP	FLII FLNA GALC MAN2A2 MAN2A1 ZMPSTE24 RBBP4 PPM1D ACO1 WRN HAT1 LBR ACY1 NT5C PRKD3 GGH UBE2E1 ADSS2 WDR11 NFE2L2 EIF4B SEC23IP AHR PIP5K1B GNB2 NMT1 NSMAF NPAT	8.98e-08	1399	169	28	M535
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FOLH1 ADGRV1 CPS1 LRP1B KCNA4 GUCY2F PCDH15 DNAH5	5.35e-07	184	169	8	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FOLH1 ADGRV1 CPS1 LRP1B KCNA4 GUCY2F PCDH15 DNAH5	5.35e-07	184	169	8	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FOLH1 ADGRV1 CPS1 LRP1B KCNA4 GUCY2F PCDH15 DNAH5	5.35e-07	184	169	8	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TRIM72 FLNA NAALAD2 ITGA7 KCNA4 SUSD5 PIP5K1B SPARCL1	6.55e-07	189	169	8	07208d32afca6f93207a2ac35b647b31a9f71b7c
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TRIM72 FLNA NAALAD2 ITGA7 KCNA4 SUSD5 PIP5K1B SPARCL1	6.55e-07	189	169	8	032f169e8ede653117919bf97c17f92043320b3c
ToppCell	facs-Lung-Endomucin-24m-Endothelial-Capillary_Type_1_Cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADGRV1 CPS1 LRP1B GUCY2F SUSD5 PCDH15 SLC17A6	1.39e-06	145	169	7	96712c68ab759d7ade0d912581a1a7c25dc6def8
ToppCell	Children_(3_yrs)-Immune-mast_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	TDRD15 AFF2 KIAA1549 LRP1B SYT10 UBA7 ST8SIA6	1.82e-06	151	169	7	bbf735c6433c3fc2feedb24ed6f48c51d545fb60
ToppCell	facs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CDHR2 ADGRV1 CPS1 LRP1B GUCY2F SUSD5 PCDH15	2.91e-06	162	169	7	bf886e22ff2a20353499004b53f25fb9e6574896
ToppCell	facs-MAT-Fat-18m-Myeloid-macrophage\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLBD1 CORO2A RPS6KA1 SLC15A3 SGK3 AHR ADSS1	3.56e-06	167	169	7	c2952d8ba763374c5678b92825c8956fc3e3ecd2
ToppCell	Fetal_29-31_weeks-Epithelial-ciliated_cell-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CDHR3 PPIL6 RABL2B RABL2A CABCOCO1 DNAH5 MUC4	6.04e-06	181	169	7	dfce05bd472f67e6e2bb60ebd6fd34f0a9aeeca6
ToppCell	IPF-Myeloid-Mast\|Myeloid / Disease state, Lineage and Cell class	GALC AFF2 KIAA1549 ALS2 TSEN54 LCN6 ST8SIA6	6.73e-06	184	169	7	7326a16d7d3ae41b8c9d2beaec7f977b374f3469
ToppCell	Mesenchymal_cells-Smooth_muscle\|Mesenchymal_cells / Lineage and Cell class	FLNA MYOM3 ITGA7 BCR PIP5K1B SPARCL1 ADSS1	6.73e-06	184	169	7	83987abaedc26e6da477bc70d65e10b1ab1aea60
ToppCell	(5)_Pericytes-(50)_Pericytes\|World / Cell class and subclass of bone marrow stroma cells in homeostatis	FLNA NAALAD2 ITGA7 PLA2R1 PIP5K1B SPARCL1 ARAP2	7.22e-06	186	169	7	67b59defdd1ed3608229cc5e2a3b480d92312afa
ToppCell	(5)_Pericytes\|World / Cell class and subclass of bone marrow stroma cells in homeostatis	FLNA NAALAD2 ITGA7 PLA2R1 PIP5K1B SPARCL1 ARAP2	7.22e-06	186	169	7	acbca8cc048d87faf859b3e77bdb38d0a3dad71c
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FLNA COL6A2 NAALAD2 ITGA7 SUSD5 PIP5K1B SPARCL1	8.02e-06	189	169	7	127ad2ba3e794df8cce2eee3e4171bccb5aad51b
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FLNA COL6A2 NAALAD2 ITGA7 SUSD5 PIP5K1B SPARCL1	8.02e-06	189	169	7	2cfb4d12f75678d1619f4743838a0e954bd57761
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FMO1 AFF2 CDHR3 MYOM3 KIAA1549 FLVCR2 GDA	8.30e-06	190	169	7	989d4eefd22d66ecb857836f8fdbcf41e3047f84
ToppCell	COVID-19-lung-Secretory\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CORO2A ADGRV1 KLF5 AHR TNS4 DNAH5 MUC4	8.89e-06	192	169	7	59261098ccb52306f837f632ebaea45b90ad30fe
ToppCell	IPF-Epithelial-Ciliated\|Epithelial / Disease state, Lineage and Cell class	CDHR3 PPIL6 BBS9 RABL2B RABL2A CABCOCO1 DNAH5	9.19e-06	193	169	7	ad58f5080e0ba65c845056ea6b79037b636e9c64
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FLNA COL6A2 NAALAD2 ITGA7 SUSD5 PIP5K1B SPARCL1	9.51e-06	194	169	7	5c3b2b05d1e4f146551fe4c920263d8e6ca34de3
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FLNA COL6A2 NAALAD2 ITGA7 SUSD5 PIP5K1B SPARCL1	9.51e-06	194	169	7	ab9cad697f9209d2889bc02b43b502dfeb2ebfef
ToppCell	COVID-19-lung-Pericytes/_Smooth_Muscle\|lung / Disease (COVID-19 only), tissue and cell type	COL6A2 AFF2 ITGA7 SEMA6D SUSD5 SPARCL1 PCDH18	9.51e-06	194	169	7	5e1e0513a54ec4cf0b247ec85c9fbc68dfac1da3
ToppCell	PND10-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FMO1 RIPPLY3 JUN SEMA6D AHR FGD5 SPARCL1	9.51e-06	194	169	7	1b382508453c5b08fb617f626b230adf3b6cff99
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CORO2A KIAA1549 TBC1D9 KLF5 KCNK1 AHR GAREM1	9.83e-06	195	169	7	3d6d3de8ada6dce3dc789c15b50cc066e7100496
ToppCell	mild-HLA-DR-_S100A+_Monocyte\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	PLBD1 DSC2 SLC15A3 CR1 TBC1D9 AHR KIF13A	1.12e-05	199	169	7	d0d286eafe935f9b3aaba5b783e8911251121b4a
ToppCell	LPS_IL1RA_TNF-Mesenchymal_myocytic\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	FLNA COL6A2 AFF2 SYT10 SUSD5 SPARCL1 PCDH18	1.16e-05	200	169	7	f599e4b051ac3dad11ad437e98dc8ea6754cca53
ToppCell	LPS_IL1RA-Mesenchymal_myocytic-Pericyte\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	FLNA COL6A2 AFF2 SEMA6D SUSD5 SPARCL1 PCDH18	1.16e-05	200	169	7	b22cae282591d8dead9869c2adbb9632615f50f7
ToppCell	distal-2-Epithelial\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CDHR3 PPIL6 KLF5 KCNK1 DNAH5 MUC4 SLC6A14	1.16e-05	200	169	7	2fc1e95706f212bf18ecdf6eb5b3182ac98c9b52
ToppCell	Control_saline-Mesenchymal_myocytic-Pericyte\|Control_saline / Treatment groups by lineage, cell group, cell type	FLNA COL6A2 AFF2 SEMA6D SUSD5 SPARCL1 PCDH18	1.16e-05	200	169	7	cb7ef774b6d300f8019c5b16a04e3ebd165e4f1c
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Lamp5-Lamp5_Ntn1_Npy2r\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	FMO1 CPS1 PRKD3 PIP5K1B SV2C PCDH18	2.18e-05	148	169	6	5e738522d4ad35e08bc4ff8c41b7bea38ec6ef95
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D175\|Adult / Lineage, Cell type, age group and donor	RIPPLY3 TSEN54 KLF5 CENPI DNAH5 MUC4	2.18e-05	148	169	6	012845b10850bbc67814da247ee5a69f6d631eaa
ToppCell	droplet-Kidney-nan-24m-Lymphocytic-CD45____macrophage\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLBD1 ADGRV1 ZNF710 GDA KLF5 ADSS1	2.35e-05	150	169	6	34774b015adecc2be56a471fda8994e89a6ad93e
ToppCell	COVID-19-Mast_cells-Mast_cells\|COVID-19 / group, cell type (main and fine annotations)	GALC AFF2 KIAA1549 ALS2 LRP1B ST8SIA6	2.93e-05	156	169	6	bc10b94673184ef384c6665b16a1209a8975a4f1
ToppCell	COVID-19-Mast_cells\|COVID-19 / group, cell type (main and fine annotations)	GALC AFF2 KIAA1549 ALS2 LRP1B ST8SIA6	2.93e-05	156	169	6	159504d43421ee83b9ab484816333ae549c9c2fd
ToppCell	PND03-Immune-Immune_Myeloid-DC-cDC1-cDC1_prolif\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PLBD1 CORO2A HAT1 TBC1D9 P2RX7 SV2C	2.93e-05	156	169	6	af47a4b17342bdb3cb62d7e2d52a81168e588629
ToppCell	droplet-Liver-Hepatocytes-24m-Myeloid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNA GALC ZNF710 PLEKHM2 PRKCB PLXNA1	3.04e-05	157	169	6	ec433d2fe827abdb647be4176c231b7052482b6f
ToppCell	TCGA-Uterus-Primary_Tumor-Uterine_Carcinoma-Uterine_Carcinosarcoma-3\|TCGA-Uterus / Sample_Type by Project: Shred V9	MAN2A1 TBC1D9 ST8SIA6 TMEM168 AHR SLC6A14	3.75e-05	163	169	6	d64dd39b077105c73e570ccef70f0e74a2c586ac
ToppCell	tumor_Lung-T/NK_cells-Cytotoxic_CD8+_T\|T/NK_cells / Location, Cell class and cell subclass	FLNA CDHR2 PRKCB GNAL DNAH5 KLRD1	3.88e-05	164	169	6	60fe6bb86afaebd92590135f08f5434ce0d8d73c
ToppCell	metastatic_Brain-Fibroblasts-Smooth_muscle_cells\|metastatic_Brain / Location, Cell class and cell subclass	FLNA LAYN ITGA7 SEMA6D SUSD5 SPARCL1	4.15e-05	166	169	6	0da2c6ea1e62f1aafabafbbfbbcc6f7011739346
ToppCell	Control-Mast_cells\|Control / group, cell type (main and fine annotations)	GALC KIAA1549 ALS2 LRP1B ST8SIA6 PRKCB	4.59e-05	169	169	6	fdb9abca1d0f4fdc32dd8ac6231651ef34aa5afb
ToppCell	facs-Lung-24m-Hematologic-myeloid-classical_monocyte-classical_monocyte_l2\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FLNA PLBD1 ZNF710 GDA FAM111A ADSS1	4.59e-05	169	169	6	907e4c7d0df6dd46664d69834251aebca8e1dd1e
ToppCell	Control-Mast_cells-Mast_cells\|Control / group, cell type (main and fine annotations)	GALC KIAA1549 ALS2 LRP1B ST8SIA6 PRKCB	4.74e-05	170	169	6	c80f6d29096c372da95a8407f402349ff1bb7018
ToppCell	facs-Lung-EPCAM-18m-Myeloid-Myeloid_Dendritic_Type_1\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLBD1 CORO2A TBC1D9 ST8SIA6 PRKCB KLRD1	4.90e-05	171	169	6	7c4362eeacbe52d7f4fdf93c841d7b59526328c1
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Hematopoietic-B_cells\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	LCN6 ABCB4 SGK3 PRKCB MUC4 TOP2B	4.90e-05	171	169	6	a350a5f840e0fb0ccd29bb29cacc23a89abd8404
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Hematopoietic-B_cells-Pro-B\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	LCN6 ABCB4 SGK3 PRKCB MUC4 TOP2B	4.90e-05	171	169	6	e0a99ca8d4c86b58f54af7755ffd8e0ffbfae5e1
ToppCell	facs-Large_Intestine-Proximal-3m-Epithelial\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DSC2 CORO2A CDHR2 JUN GDA NMT1	5.22e-05	173	169	6	e1378201b15ffb98e196ac39fe3ee4b4078953bd
ToppCell	facs-Large_Intestine-Proximal-3m\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DSC2 CORO2A CDHR2 JUN GDA NMT1	5.22e-05	173	169	6	99532bb768ee35fed939a377acb5215d3f8904bd
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Degenerative_Vascular_Smooth_Muscle_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FLNA COL6A2 GABRQ EEF2 SUSD5 SPARCL1	5.22e-05	173	169	6	ecbf7167d4bec685e3460d826318544946f5f5c2
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Degenerative_Vascular_Smooth_Muscle_Cell-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FLNA COL6A2 GABRQ EEF2 SUSD5 SPARCL1	5.22e-05	173	169	6	b8dc978c52de64afba21ff6cb32e79f07167448e
ToppCell	PND03-Epithelial-Epithelial_Airway-Neurosecretory-PNEC-PNEC_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DSC2 ABCB4 CACNA2D4 KCNJ6 CENPI PLXNA1	5.57e-05	175	169	6	8362a46f5804333baa84cd56d450bc147f372a7e
ToppCell	PND03-Epithelial-Epithelial_Airway-Neurosecretory-PNEC\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DSC2 ABCB4 CACNA2D4 KCNJ6 CENPI PLXNA1	5.57e-05	175	169	6	8b4c62e608f0ec84e563bbf0ebffe3ed44085298
ToppCell	343B-Fibroblasts-Fibroblast-A_(Fibroblast_progenitors)-\|343B / Donor, Lineage, Cell class and subclass (all cells)	COL6A2 NAALAD2 LRP1B NRXN2 SPARCL1 PCDH18	5.75e-05	176	169	6	2e94bbe17c0bb65dc58b4ebc0cb829258bd7373b
ToppCell	Frontal_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Nptxr-Excitatory_Neuron.Slc17a7.Nptxr-Drd1_(Deep_layer_pyramidal_cells)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	SYNRG UBE2E1 WDR11 QARS1 PLXNA1 NSMAF	5.75e-05	176	169	6	3c76a5c4ca2b378667cb155fbb9675519572b35d
ToppCell	COVID-19-lung-MAST\|COVID-19 / Disease (COVID-19 only), tissue and cell type	GALC KIAA1549 ALS2 TSEN54 ST8SIA6 PRKCB	5.75e-05	176	169	6	473c45a381ca109207d66ed1635668b391ea0e1f
ToppCell	343B-Fibroblasts-Fibroblast-A_(Fibroblast_progenitors)\|343B / Donor, Lineage, Cell class and subclass (all cells)	COL6A2 NAALAD2 LRP1B NRXN2 SPARCL1 PCDH18	5.75e-05	176	169	6	f33ab41d121b59d871ad7d48ca021524a027d2ef
ToppCell	PND10-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1-CAP1_prolif\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FMO1 RIPPLY3 JUN SEMA6D AHR SPARCL1	5.75e-05	176	169	6	269326c2bf44a9003d95bc6dbc839f08f25737ca
ToppCell	CV-Severe-7\|CV / Virus stimulation, Condition and Cluster	ENTPD7 MAN2A1 HUWE1 PARP14 TMEM168 ASMT	5.75e-05	176	169	6	3de0c7d77210049e5616db21eed1490a17a5ec2d
ToppCell	5'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell-Pericytes-Pericytes_L.2.3.3.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	COL6A2 AFF2 SEMA6D KCNJ6 SPARCL1 PCDH18	6.31e-05	179	169	6	dc6cd46fa652b296ddbc41855f6377946d0a4cdc
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_SST_CXCL14\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	AFF2 SYT10 SEMA6D ST8SIA6 GNAL PCDH18	6.31e-05	179	169	6	c7afbd10072d36a35cd20ae73670d76b9cefd22d
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_ILC-NK_cell\|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)	CORO2A FAXC ALS2 ADGRV1 ABCB4 PIP5K1B	6.51e-05	180	169	6	1bc01bb76d0d3f8db74f9244436d3e6d6015ed5d
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_ILC\|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)	CORO2A FAXC ALS2 ADGRV1 ABCB4 PIP5K1B	6.51e-05	180	169	6	2a28fbfe10a340c8662c2c8be33792f41fc09088
ToppCell	Children_(3_yrs)-Epithelial-club_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ADGRV1 JUN SEMA6D DNAH5 MUC4 GAREM1	6.51e-05	180	169	6	b509c7d6bdfba672065fb722874bdc68de72ba1c
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_ILC-NK_cell-NK_c01-FCGR3A\|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)	CORO2A FAXC ALS2 ADGRV1 ABCB4 PIP5K1B	6.51e-05	180	169	6	12f3c4c4aa7fe03c0ef847bd4d4942c808015f5f
ToppCell	PND07-28-samps-Endothelial-Postnatal_endothelial-capillary_endothelial_Hpgd-CA4_high\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	FMO1 RIPPLY3 SEMA6D AHR FGD5 ARAP2	6.71e-05	181	169	6	9cd5e5c285c2b628db9d59709af053defd7c0aff
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	FMO1 CDHR3 MYOM3 KIAA1549 GDA PCDH15	6.71e-05	181	169	6	9542c19edc9bd2cba68c01c2a8407705398e3011
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	FMO1 CDHR3 MYOM3 KIAA1549 GDA PCDH15	6.71e-05	181	169	6	8f04f8cac5d705dc5f6cf6f4516d6e45b0aa4ae5
ToppCell	droplet-Lung-immune-endo-depleted-3m-Myeloid\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLVCR2 SLC15A3 TBC1D9 IVNS1ABP PLEKHM2 FHIP2B	6.92e-05	182	169	6	3dec003bad0f3716cf8163861a9d4302a7d6df8c
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	OGT TBC1D9 IVNS1ABP SEMA6D NFE2L2 TRPV5	7.13e-05	183	169	6	2f0ee40e69ad1259e56e8ee4b352736900eb8901
ToppCell	IPF-Myeloid-Mast\|World / Disease state, Lineage and Cell class	GALC AFF2 KIAA1549 ALS2 TSEN54 ST8SIA6	7.35e-05	184	169	6	7aefa182acad5a53c730945fec85329d7168606a
ToppCell	PND07-Immune-Immune_Myeloid-Monocytic-Macrophage-AM\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CORO2A FLVCR2 SLC15A3 TBC1D9 IVNS1ABP GDA	7.35e-05	184	169	6	8e5fc2bdd3071e782aa8c56b8a39f8ea8f03f623
ToppCell	IPF-Myeloid-Mast\|IPF / Disease state, Lineage and Cell class	GALC AFF2 KIAA1549 ALS2 TSEN54 ST8SIA6	7.35e-05	184	169	6	c3baf21f10b45cf91ac99997a59f353bcf3de8b7
ToppCell	droplet-Lung-immune-endo-depleted-3m-Myeloid-alveolar_macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLVCR2 SLC15A3 TBC1D9 IVNS1ABP PLEKHM2 FHIP2B	7.57e-05	185	169	6	afbb88325e4a81c15ac1d0a004e3e1f4ba2ee87b
ToppCell	COPD-Myeloid-Mast\|COPD / Disease state, Lineage and Cell class	GALC MAN2A1 KIAA1549 LCN6 ST8SIA6 AHR	7.80e-05	186	169	6	def6f0f284acc2154738574c8c5d3d2a5ef1f208
ToppCell	facs-Lung-EPCAM-3m-Epithelial-Ciliated_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDHR3 PPIL6 IL22RA1 SYT10 DNAH5 MUC4	8.03e-05	187	169	6	04dba2ed09ee4180830bdf0191921696697ea234
ToppCell	facs-Lung-EPCAM-3m-Epithelial-ciliated_columnar_cell_of_tracheobronchial_tree\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDHR3 PPIL6 IL22RA1 SYT10 DNAH5 MUC4	8.03e-05	187	169	6	805dafe22f835ece4dd091d8030d0a63b52a48dd
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FLNA COL6A2 AFF2 ITGA7 SUSD5 PIP5K1B	8.27e-05	188	169	6	b2d68a32314e9b099ed74d974079ad96359d1ae3
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FMO1 CDHR3 MYOM3 KIAA1549 GDA PCDH15	8.27e-05	188	169	6	f3edcefeef2ce19086032d98b243c02a6d542b38
ToppCell	facs-Lung-EPCAM-24m-Epithelial\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDHR3 PPIL6 KLF5 KCNK1 DNAH5 MUC4	8.27e-05	188	169	6	c2ef270f691d367b1621d48f0771267cefe1630d
ToppCell	Mast_cells\|World / lung cells shred on cell class, cell subclass, sample id	AFF2 KIAA1549 ALS2 TSEN54 LCN6 ST8SIA6	8.27e-05	188	169	6	229d24b87e945c4d543d11ac70761e45175ba0e5
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FMO1 CDHR3 MYOM3 KIAA1549 GDA PCDH15	8.27e-05	188	169	6	0792432cd4c564dea1102241ea9884f7ced7658c
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	LRP1B TBC1D9 IVNS1ABP SEMA6D PIP5K1B KLRD1	8.52e-05	189	169	6	975c0f079903ae36b0ffa54e86294d42ec7697de
ToppCell	COVID-19-lung-Secretory\|lung / Disease (COVID-19 only), tissue and cell type	ADGRV1 KLF5 TNS4 DNAH5 MUC4 GAREM1	8.52e-05	189	169	6	84d48e3ed25bebb8bb8074b3a2c5e2e88cff7f25
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	TBC1D9 IVNS1ABP SEMA6D NFE2L2 PIP5K1B KLRD1	8.52e-05	189	169	6	7eb8f5a951e80f1cfac4d7c9eb169f4eb100c917
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FLNA NAALAD2 ITGA7 SUSD5 PIP5K1B SPARCL1	8.52e-05	189	169	6	7fbe855bfdb47d35e040b04a80fe4b729a3764e8
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FLNA NAALAD2 ITGA7 SUSD5 PIP5K1B SPARCL1	8.52e-05	189	169	6	06b35abecd29f902cf251fcc1f6ad33db7ab08a2
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophage_CCL3+\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PLBD1 ACO1 SLC15A3 CR1 P2RX7 SUSD5	8.52e-05	189	169	6	1f4fe19e500bfedd48b1f34827a44e796f6db3e1
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	TRIM72 COL6A2 AFF2 ITGA7 SUSD5 PIP5K1B	8.52e-05	189	169	6	fac5c291a9a87418bb0878c3d624829bdbf1f428
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophage_CCL3+-Alveolar_macrophage_CCL3+_L.1.0.2.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PLBD1 ACO1 SLC15A3 CR1 P2RX7 SUSD5	8.52e-05	189	169	6	bfa1dfc93ad33a9dbef316c0591b950d062b35eb
ToppCell	3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PARP14 KLF5 KCNK1 MUC4 SLC6A14 GAREM1	8.77e-05	190	169	6	6ea9fa08bd97bedcb21d3654467e7f8dd74c8fd0
ToppCell	P03-Mesenchymal-developing_mesenchymal_cell-mesenchymal_myogenic_precursor_(Axin2+)\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	NAALAD2 AFF2 BCR PLA2R1 SPARCL1 PCDH18	8.77e-05	190	169	6	979b1476fd2692fde977ce56257315fcfc8a01d5
ToppCell	control-Myeloid-Immature_Neutrophils_1\|control / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	PLBD1 AFF2 CORO2A IVNS1ABP ADSS2 KLF5	8.77e-05	190	169	6	38e83337c70c8734b63f8589ba59e0f98603f94c
ToppCell	NS-critical-d_07-13-Epithelial-FOXN4+\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	FAXC SYT10 GGH SSX2IP CENPI GNAL	8.77e-05	190	169	6	7be0f2ff86ca8500a43e0d44e5e292530f9ba0bb
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FLNA COL6A2 AFF2 ITGA7 PIP5K1B SPARCL1	8.77e-05	190	169	6	5681c211baeed4af82a2bbc13420f6a7b487581c
ToppCell	COPD-Epithelial-Club\|COPD / Disease state, Lineage and Cell class	ADGRV1 KLF5 KCNK1 AHR DNAH5 MUC4	9.02e-05	191	169	6	c909cf5fa0e6519aa93a47d2c3fcd2ae2163cd8d
ToppCell	PND03-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP2-CAP2_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FMO1 RIPPLY3 JUN AHR FGD5 ARAP2	9.02e-05	191	169	6	718330bb97fe8a1ffd0c82e9af23311a32eacfe1
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	COL6A2 ITGA7 SYT10 SUSD5 SPARCL1 PCDH18	9.02e-05	191	169	6	7853ac7dff649150e6ff27cd4c8cf7c1fc034ed4
ToppCell	ILEUM-non-inflamed\|ILEUM / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	TSEN54 JUN SEMA6D KLF5 SPARCL1 KLRD1	9.02e-05	191	169	6	c4a78ef7b87ffadbb1b9b69cbfa7c164ca456f9a
ToppCell	PND07-Epithelial-Epithelial_Airway\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DSC2 CDHR3 PPIL6 SYT10 KLF5 DNAH5	9.02e-05	191	169	6	b55500eb416f4f339031acad16b2737e5b891d8e
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FLNA COL6A2 AFF2 ITGA7 PIP5K1B SPARCL1	9.29e-05	192	169	6	24e2f15f5767a97eb3b389922bcfd7b13805e1ce
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FLNA COL6A2 ITGA7 SYT10 SUSD5 PCDH18	9.29e-05	192	169	6	992d08092edbc68c47b945deb8708379738c239a
Drug	glutamate	NAALAD2 FOLH1 ACO1 GABRQ ALS2 RELB CPS1 SGK3 PRKD3 GGH JUN GDA EEF2 CACNA2D4 KCNA4 P2RX7 NFE2L2 KCNJ6 SLC17A8 PRKCB QARS1 PLOD1 TRPV5 SLC17A6	1.97e-07	962	169	24	CID000000611
Drug	Azacyclonol [115-46-8]; Down 200; 15uM; HL60; HG-U133A	IRF2BP1 JMJD4 PRKD3 JUN USP5 PLEKHM2 SEC23IP SMARCA4 NMT1 PLXNA1 ILVBL	2.84e-07	198	169	11	2020_DN
Drug	antibiotic from Streptomyces	GABRQ PRKD3 JUN ADSS2 PRKCB ADSS1	6.43e-07	42	169	6	CID000005153
Drug	tetraethylammonium	CPS1 SGK3 PRKD3 CACNA2D4 KCNA3 KCNA4 NRXN2 GUCY2F KCNJ6 KCNK1 PRKCB	1.61e-06	236	169	11	CID000005413
Drug	Ajmaline [4360-12-7]; Up 200; 12.2uM; MCF7; HT_HG-U133A	MAN2A2 IPO8 DSC2 JMJD4 PIP5K1C BBS9 JUN NRXN2 NMT1 MASP2	2.27e-06	197	169	10	7484_UP
Drug	indole alkaloid	LBR BCR TBC1D9 ABCB4 PRKD3 JUN PRKCB PLXNA1 TOP2B NSMAF	1.50e-05	244	169	10	CID000005978
Drug	Skimmianine [83-95-4]; Down 200; 15.4uM; HL60; HT_HG-U133A	FLII LZTR1 JMJD4 CPS1 ITGA7 BCR TBC1D9 KCNA3 ILVBL	1.52e-05	194	169	9	2504_DN
Drug	niguldipine	ABCB4 PRKD3 KCNA4 PRKCB TOP2B	2.04e-05	45	169	5	CID000001236
Drug	tBCEU	TBC1D9 ABCB4 TOP2B	2.19e-05	8	169	3	CID000164059
Drug	AC1L1B9H	TBC1D9 ABCB4 PRKD3 KCNA3 KCNA4 PRKCB	2.53e-05	78	169	6	CID000001341
Disease	dementia, Parkinson disease, disease progression measurement	BBS9 LRP1B	9.52e-05	3	167	2	EFO_0008336, MONDO_0001627, MONDO_0005180
Disease	sarcoma (biomarker_via_orthology)	ADSS2 ADSS1	9.52e-05	3	167	2	DOID:1115 (biomarker_via_orthology)
Disease	mucositis (biomarker_via_orthology)	MUC2 MUC4	3.15e-04	5	167	2	DOID:0080178 (biomarker_via_orthology)
Disease	mucinous adenocarcinoma (is_marker_for)	MUC2 MUC4	3.15e-04	5	167	2	DOID:3030 (is_marker_for)
Disease	ergothioneine measurement	CPS1 GDA DNAH5	4.21e-04	26	167	3	EFO_0021163
Disease	level of Sterol ester (27:1/18:2) in blood serum	TDRD15 RELB SMARCA4	4.21e-04	26	167	3	OBA_2045194
Disease	Liver Cirrhosis, Experimental	FLNA SYNRG COL6A2 GALC FMO1 CPS1 SLC15A3 BCR TBC1D9 GGH SEMA6D NFE2L2 PRKCB	4.87e-04	774	167	13	C0023893
Disease	Colorectal Carcinoma	FOLH1 WRN HAT1 ADAM29 NT5C RHEB ABCB4 GGH P2RX7 KLF5 PRKCB TNS4	6.88e-04	702	167	12	C0009402
Disease	esterified cholesterol measurement, intermediate density lipoprotein measurement	TDRD15 SMARCA4	8.72e-04	8	167	2	EFO_0008589, EFO_0008595
Disease	non-alcoholic fatty liver disease (implicated_via_orthology)	ZMPSTE24 ACO1 NFE2L2	1.11e-03	36	167	3	DOID:0080208 (implicated_via_orthology)
Disease	Silicosis	JUN AHR	1.12e-03	9	167	2	C0037116
Disease	Adenocarcinoma of lung (disorder)	SCYL2 GUCY2F KLF5 AHR DOT1L PSKH2	1.17e-03	206	167	6	C0152013
Disease	primary biliary cholangitis (is_implicated_in)	LBR ABCB4	1.39e-03	10	167	2	DOID:12236 (is_implicated_in)
Disease	allergic conjunctivitis (is_marker_for)	MUC2 MUC4	1.39e-03	10	167	2	DOID:11204 (is_marker_for)
Disease	rosacea severity measurement	RPS6KA1 SEMA6D KCNJ6 PCDH15 AHR	1.53e-03	147	167	5	EFO_0009180
Disease	craniosynostosis (is_implicated_in)	FLNA BBS9	2.02e-03	12	167	2	DOID:2340 (is_implicated_in)
Disease	Gastrointestinal Diseases	CHD8 NFE2L2	2.02e-03	12	167	2	C0017178
Disease	Functional Gastrointestinal Disorders	CHD8 NFE2L2	2.02e-03	12	167	2	C0559031
Disease	Cholera Infantum	CHD8 NFE2L2	2.02e-03	12	167	2	C1565321
Disease	phospholipid measurement, intermediate density lipoprotein measurement	TDRD15 IRF2BP1 RELB SMARCA4	2.45e-03	99	167	4	EFO_0004639, EFO_0008595
Disease	phoneme awareness	DDX27 KCNJ6	2.77e-03	14	167	2	EFO_0021812
Disease	insulin metabolic clearance rate measurement, glucose homeostasis measurement	RPS6KA1 ST8SIA6	2.77e-03	14	167	2	EFO_0006830, EFO_0006896
Disease	esterified cholesterol measurement, low density lipoprotein cholesterol measurement	TDRD15 SMARCA4	2.77e-03	14	167	2	EFO_0004611, EFO_0008589
Disease	free cholesterol measurement, intermediate density lipoprotein measurement	TDRD15 IRF2BP1 RELB SMARCA4	2.93e-03	104	167	4	EFO_0008591, EFO_0008595
Disease	type 2 diabetes mellitus (implicated_via_orthology)	OGT ZMPSTE24 AFF2 RHEB	3.04e-03	105	167	4	DOID:9352 (implicated_via_orthology)
Disease	response to trauma exposure	BBS9 KCNK1 ILVBL	3.04e-03	51	167	3	EFO_0008483
Disease	Hepatomegaly	NFE2L2 AHR CABCOCO1	3.57e-03	54	167	3	C0019209
Disease	Ciliopathies	ADGRV1 BBS9 PCDH15 DNAH5	3.59e-03	110	167	4	C4277690
Disease	level of Sterol ester (27:1/18:1) in blood serum	RELB SMARCA4	3.63e-03	16	167	2	OBA_2045195
Disease	Glioblastoma Multiforme	LZTR1 PRKD3 GUCY2F PRKCB	3.71e-03	111	167	4	C1621958
Disease	phenylalanine measurement	CPS1 PCDH15 KIF13A	3.76e-03	55	167	3	EFO_0005001
Disease	Necrosis	BCR NFE2L2 AHR	3.76e-03	55	167	3	C0027540
Disease	hepcidin:ferritin ratio	OTOL1 LRP1B SV2C	3.76e-03	55	167	3	EFO_0007901
Disease	lipoprotein A measurement	TDRD15 PNLDC1 CPS1 SMARCA4	3.83e-03	112	167	4	EFO_0006925
Disease	free cholesterol measurement	TDRD15 IRF2BP1 RELB SMARCA4	3.95e-03	113	167	4	EFO_0008591
Disease	essential hypertension, age at diagnosis	REXO1 FGD5 PCDH18	3.96e-03	56	167	3	EFO_0004918, MONDO_0001134
Disease	low density lipoprotein cholesterol measurement, lipid measurement	TDRD15 RELB SMARCA4 DMRT1	4.08e-03	114	167	4	EFO_0004529, EFO_0004611
Disease	conotruncal heart malformations	ADAM29 ADGRV1 SLC15A3 AHR	4.08e-03	114	167	4	MONDO_0016581
Disease	total cholesterol measurement, low density lipoprotein cholesterol measurement	TDRD15 RELB SMARCA4 DMRT1	4.08e-03	114	167	4	EFO_0004574, EFO_0004611
Disease	Drug habituation	PLA2R1 SEMA6D WDR11 PCDH15	4.20e-03	115	167	4	C0013170
Disease	Drug abuse	PLA2R1 SEMA6D WDR11 PCDH15	4.20e-03	115	167	4	C0013146
Disease	Prescription Drug Abuse	PLA2R1 SEMA6D WDR11 PCDH15	4.20e-03	115	167	4	C4316881
Disease	Substance-Related Disorders	PLA2R1 SEMA6D WDR11 PCDH15	4.20e-03	115	167	4	C0236969
Disease	Drug Use Disorders	PLA2R1 SEMA6D WDR11 PCDH15	4.20e-03	115	167	4	C0013222
Disease	Drug Dependence	PLA2R1 SEMA6D WDR11 PCDH15	4.20e-03	115	167	4	C1510472
Disease	Substance Dependence	PLA2R1 SEMA6D WDR11 PCDH15	4.20e-03	115	167	4	C0038580
Disease	Substance Use Disorders	PLA2R1 SEMA6D WDR11 PCDH15	4.20e-03	115	167	4	C0038586
Disease	Organic Mental Disorders, Substance-Induced	PLA2R1 SEMA6D WDR11 PCDH15	4.20e-03	115	167	4	C0029231
Disease	cancer (implicated_via_orthology)	ITGA7 PIP5K1C SMARCA4 PIP5K1A PIP5K1B TOP2B	4.33e-03	268	167	6	DOID:162 (implicated_via_orthology)
Disease	Substance abuse problem	PLA2R1 SEMA6D WDR11 PCDH15	4.33e-03	116	167	4	C0740858
Disease	pyroglutamine measurement	CPS1 UBE2E1 KCNK1	4.37e-03	58	167	3	EFO_0005408
Disease	congenital heart disease	ADAM29 LRP1B AHR	4.59e-03	59	167	3	EFO_0005207
Disease	very low density lipoprotein cholesterol measurement, esterified cholesterol measurement	TDRD15 SMARCA4	4.59e-03	18	167	2	EFO_0008317, EFO_0008589
Disease	cardiovascular disease	TDRD15 WRN REXO1 SMARCA4 FGD5 NMT1 CABCOCO1 PCDH18	4.65e-03	457	167	8	EFO_0000319
Disease	low density lipoprotein cholesterol measurement, phospholipid measurement	TDRD15 RELB SMARCA4 DMRT1	4.89e-03	120	167	4	EFO_0004611, EFO_0004639
Disease	cholesterol:total lipids ratio, intermediate density lipoprotein measurement	TDRD15 RELB CPS1 SMARCA4	5.03e-03	121	167	4	EFO_0008595, EFO_0020943
Disease	response to opioid	IPO8 CACNA2D4 SEC23IP	5.04e-03	61	167	3	EFO_0008541
Disease	blood arsenic measurement	FGD5 PLOD1	5.11e-03	19	167	2	EFO_0021527

Protein segments in the cluster

Peptide	Gene	Start	Entry
PYVQEAEEGSCFDSF	TMEM184C	316	Q9NVA4
PEYGATAAFFPVDEV	ACO1	301	P21399
FTTGEAVLYEATNPF	AHR	406	P35869
FTYTDQGAILEDQPF	ADAM29	81	Q9UKF5
ELPSGQYTEAEEFFV	CHD8	656	Q9HCK8
NPLEEGISFDIYSTF	CABCOCO1	111	Q8IVU9
DFGTSLPFIDIYFST	CATSPER3	341	Q86XQ3
YSLFLVDTEDFQPGL	ALS2	621	Q96Q42
TDEFYPNFAEGIALS	BCR	1141	P11274
ISYLDQELTTFGFPS	SSX2IP	66	Q9Y2D8
QELTTFGFPSLYEES	SSX2IP	71	Q9Y2D8
DDLFSSGFDLFGEPY	AFF2	41	P51816
FDPYENFFEDSDSPT	GVINP1	941	Q7Z2Y8
ASDDPYGIFIFSEKN	ADGRV1	1971	Q8WXG9
EASDDPYGLFGFQIT	ADGRV1	2226	Q8WXG9
ENSSSIFPYGETFLF	ARAP2	326	Q8WZ64
YLETFGVPAEELFTA	ASMT	131	P46597
FSPEVYGETSFDLVA	DOT1L	131	Q8TEK3
PFDTGYTFRNPEDIF	DNAJB8	86	Q8NHS0
DLFFLEEGPSYAFEV	CDAN1	761	Q8IWY9
DFNPDFVFTEKEGTY	DDX27	81	Q96GQ7
YESFEIIAFATTPDG	DSC2	206	Q02487
VASVYEAPGFFLDLE	NT5C	61	Q8TCD5
DDGFAYDPTAPTLFT	RELB	486	Q01201
LSPASSGNAVYDFFI	LBR	356	Q14739
ISYIFEGDPIDTFVA	PCDH18	366	Q9HCL0
YELFTDFTFLVTSGP	KIAA1549	991	Q9HCM3
SDPAFQALFDLFDYG	NPAT	321	Q14207
FSLPLYFVSAADGTN	RABL2A	151	Q9UBK7
FSLPLYFVSAADGTN	RABL2B	151	Q9UNT1
FFDEDPSIFSPGSVY	AOC2	706	O75106
YAQREDFEAAGSPFS	POU5F1B	291	Q06416
GSEEPFSFYGDIIAF	FAXC	31	Q5TGI0
DSLYFTDNGQIIFPE	MUC4	4356	Q99102
ITYALLSGFLPFDDE	PSKH2	251	Q96QS6
DYSEFFTEDVGQLPG	FLII	486	Q13045
GVDIDNPYFNFITAF	LRP1B	1586	Q9NZR2
DSVEYLTLNFGPFET	LZTR1	36	Q8N653
NGEVTDFLSFYTLPS	NMT1	391	P30419
FPVLSGDFFTYADRD	MAN2A1	486	Q16706
SPIDFNNSEFYGFSE	ENTPD7	406	Q9NQZ7
YLFEIFNSDSDPHGI	IVNS1ABP	56	Q9Y6Y0
ETTFYDDALNASFLP	JUN	6	P05412
FTPVLTLEDGFYEVD	KCNJ6	336	P48051
TEGFSFDLFNPDYVP	GABRQ	591	Q9UN88
SGFVTNDIYEFSPDQ	LAYN	351	Q6UX15
AVGLAAYELFDSVDF	IPO11	456	Q9UI26
SEAYFSAAEEFEPIS	KIAA1109	1391	Q2LD37
FGAVVFSSVELPYED	KCNK1	36	O00180
AGESFPGIYDALFDI	FOLH1	701	Q04609
FEFSPGTLQVYSDSL	PLXNA1	1226	Q9UIW2
DPYFTDSFLDSGFQT	FHIP2B	501	Q86V87
EDPGLEYSFSSFDLS	KIAA0232	1031	Q92628
QSYSEFLSDGVLFSP	MUC2	176	Q02817
DFYVVESVFLPSEGS	PIP5K1B	56	O14986
FGDEFYSAFIAEPSI	NFE2L2	281	Q16236
EDFVTSLTGSPYEFF	FGD5	336	Q6ZNL6
SDYLFPEASEESAGI	GAREM1	431	Q9H706
PDYALFTQSADGTTF	HACE1	611	Q8IYU2
FDSSLPPTDDEDFYT	NRXN2	1501	Q9P2S2
ASFPVQATIDFYDDE	RIPPLY3	101	P57055
LFSSAVYFAEADDPT	KCNA3	411	P22001
VYFAEADDPTSGFSS	KCNA3	416	P22001
FGDEPFNTVELYSLT	LCN6	126	P62502
IYVSLSGTFPFNEDE	PRKD3	766	O94806
ESDINAVAFFPNGYA	GNB2	226	P62879
EFAGFSYTNPEFVIN	PRKCB	656	P05771
YDFFSGEFVVSPEPD	PPM1D	281	O15297
LPQAFDQFFETAYGT	HOXA11	136	P31270
DQFFETAYGTPENLA	HOXA11	141	P31270
DFQDSIFEYFNTAPL	CDC42BPB	946	Q9Y5S2
LGFLYSEDSAPAFAI	MFSD11	376	O43934
ESIYGPTFEDENFSV	PPIL6	221	Q8IXY8
TTLHFEFYADPGAEV	HUWE1	196	Q7Z6Z7
QDFYVVESIFFPSEG	PIP5K1A	111	Q99755
SFSSYPGFLESLDDF	PLBD1	276	Q6P4A8
PGFLESLDDFYILSS	PLBD1	281	Q6P4A8
FSGSIPLQEYFELID	BBS9	636	Q3SYG4
FNPYSEFILATGSAD	RBBP4	281	Q09028
ILFADSYDVLFASGP	PLOD1	96	Q02809
YDPLAGTVFVDFGFQ	ABCB4	1086	P21439
IAPITDFEYSQEFFD	GNAL	121	P38405
FVEGQFVDSYDPTIE	RHEB	26	Q15382
DTEIFYQFTSFLSPG	PREP	391	P48147
VEYFPEESSALIEFF	PARP14	261	Q460N5
DYEAFPDQEASITFL	PCDH15	881	Q96QU1
SVFDTADYTFPLQGN	P2RX7	86	Q99572
TPGPIDTEYLFDSFF	CPS1	381	P31327
NPGIDFDIEEFFSAS	ATMIN	631	O43313
AYFVFPNGSALTLDE	CDHR2	1101	Q9BYE9
DGAFGYSLIEFDTFV	ILVBL	521	A1L0T0
FFPEYTHQLFGDDET	HAT1	51	O14929
INDFEFPVGTSLNYE	CR1	1411	P17927
NLSIQSFDDGDYFPV	GGH	116	Q92820
VENEDGTFDIFYTAP	FLNA	1701	P21333
YFFTDISDTPFSLGV	CACNA2D4	636	Q7Z3S7
GFIYQVEAFDPEDTS	CDHR3	151	Q6ZTQ4
AFLFYGTDFNIDSLP	FUT10	121	Q6P4F1
NPDVITYDTEFFFGA	FAM111A	526	Q96PZ2
VFATGYTFAFPFLDE	FMO1	326	Q01740
EPEGFDLVTLYFSDI	GUCY2F	876	P51841
VAFVSEPGAFSYADF	JMJD4	76	Q9H9V9
IGVFTDPAHTEEFAY	NDUFAF1	301	Q9Y375
DYDSLAQPGFFDRFI	COL6A2	1001	P12110
DLDGSSGVLFPFYDA	CORO2A	266	Q92828
LGFEFAVELTYPESE	FLVCR2	421	Q9UPI3
FPVLSGDFFSYADRE	MAN2A2	486	P49641
PFTGFEAFYAAEDID	MASP2	126	O00187
AFYTFLTPDEDGSPN	ITIH6	1026	Q6UXX5
YEFFGLTPDTEFLGT	IL22RA1	186	Q8N6P7
IPEFYGDDVSFLVNS	NSMAF	446	Q92636
DSPIDLFYGDFFGDI	GDA	406	Q9Y2T3
YFGLLFVTNIDSSDP	ITGA7	266	Q13683
AYLPVNESFGFTADL	EEF2	786	P13639
GFFFASLQDDALCPY	CENPI	186	Q92674
ELFAAFGFYDSQPTL	ZMPSTE24	371	O75844
TGVFEYFTNIEDPGE	GALC	511	P54803
PQFLYEAGFSSEDSI	DHX37	286	Q8IY37
SEIFASIPGLEFAYS	SLC15A3	471	Q8IY34
LEADDAFVGFSYAPP	SGK3	476	Q96BR1
AFVGFSYAPPSEDLF	SGK3	481	Q96BR1
QFFTFEDAPSYPEAR	DMRT1	306	Q9Y5R6
AFLSYSGPFNQEFRD	DNAH5	3526	Q8TE73
VFAFDATARPPGYEF	IRF2BP1	256	Q8IU81
AEDDSIFTGFLLYPE	OTOL1	456	A6NHN0
FEVFCYALSPDDGTN	OGT	586	O15294
YTAFLGNLPYDVTEE	EIF4B	96	P23588
AIAPSSEDYDFGDVF	PLEKHM2	211	Q8IWE5
SEDYDFGDVFPAVPS	PLEKHM2	216	Q8IWE5
FDIFEDYASPTTAAQ	IPO8	381	O15397
FGDAPASLDAFVFSY	MTX1	341	Q13505
PVEFADFSVYNASLE	KIF13A	1551	Q9H1H9
FQFERLGYFSVDPDS	QARS1	741	P47897
DEDAFPLAFDYSPGS	REXO1	141	Q8N1G1
DSFPYLLSEDFFGQE	SUSD5	531	O60279
NAALLDIDFGTYPFV	ADSS1	256	Q8N142
TFIDTVFDNTDFEPY	SV2C	536	Q496J9
SFYSFRDFTLPQDVG	TSEN54	511	Q7Z6J9
YAGPEDDAAITLAFS	TOP2B	661	Q02880
LADDFGEFSLFGEYS	SYNRG	666	Q9UMZ2
LDYGNTDSIPFFDVK	TDRD15	566	B5MCY1
DFYVVESIFFPSEGS	PIP5K1C	106	O60331
YLFPTTFGILDSEFS	PNLDC1	81	Q8NA58
TFNEPGSEYFIFLLS	SMARCA4	1141	P51532
EDIATYGDAFFLLPA	ST8SIA6	256	P61647
FFDDVGAVTLQYFDT	SCYL2	326	Q6P3W7
EDDLPFLEFTGSIVY	WRN	41	Q14191
AALLDIDFGTYPFVT	ADSS2	256	P30520
YNSLDFEPEIFFALG	SEC23IP	776	Q9Y6Y8
PVVSSFLDNTYFGED	PLA2R1	756	Q13018
GIANPTDAFTVFYSE	ACY1	176	Q03154
ISQPAYFEEVFGFEI	SLC17A6	331	Q9P2U8
ESDPDLGEYFLFTSH	ZCWPW1	336	Q9H0M4
LDPTTEHIYGDNFFS	UBA7	516	P41226
DEEPYFGSLSAFVCQ	TNS4	526	Q8IZW8
SASDDYFIPSQAFLE	SPARCL1	356	Q14515
FHYAPFASDFEGIAD	XRN2	566	Q9H0D6
PDSAFEATQYFFEDI	TBC1D9	946	Q6ZT07
NELFGATISAEAFYP	ZNF710	31	Q8N1W2
DPFLDIYFSGLSVTE	TMEM168	236	Q9H0V1
FYDASDADALVPLFA	TRIM72	426	Q6ZMU5
FDETFQFPVAYDQLS	SYT10	296	Q6XYQ8
EVANFGAYAFAPATV	NIPAL4	116	Q0D2K0
IIVGADSDPFSSFYL	PSMD5	256	Q16401
SYADNILSFSFDPFD	WDR11	156	Q9BZH6
YEGGVFFLDITFTPE	UBE2E1	91	P51965
SGFDLAFIAYPEALA	SLC6A14	386	Q9UN76
VPGDSFFYFDVLQSI	SEMA6D	286	Q8NFY4
AFSFDTPESEGGLYI	USP5	31	P45974
IFQTEDPTSLGQFYD	TRPV5	511	Q9NQA5
SQPAYFEEVFGFAIS	SLC17A8	336	Q8NDX2
LFSSAVYFAEADEPT	KCNA4	491	P22459
DQFFTDTEGLPYSIN	KLF5	121	Q13887
ENGSALSQYLFPSFE	KLRD1	131	Q13241
AVAQPDDTFYFDTEF	RPS6KA1	341	Q15418
AGESFPGIYDAIFDI	NAALAD2	691	Q9Y3Q0
YLAFEAPEAPDSSEF	MYOM3	916	Q5VTT5