Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	JUN kinase activity	MAPK8 MAPK9 MAPK10	4.13e-08	3	70	3	GO:0004705
GeneOntologyMolecularFunction	MAP kinase activity	MAPK8 MAPK9 MAPK10	2.24e-05	16	70	3	GO:0004707
GeneOntologyMolecularFunction	olfactory receptor activity	OR8H2 OR4C3 OR6C1 OR6C3 OR1F2P OR5A2 OR51G1 OR8G2P	1.29e-04	431	70	8	GO:0004984
GeneOntologyMolecularFunction	protein serine/threonine/tyrosine kinase activity	MAPK8 MAPK9 MAPK10	5.99e-04	47	70	3	GO:0004712
MousePheno	abnormal choroid pigmentation	HPS4 VPS33A LYST	1.82e-05	14	53	3	MP:0005100
MousePheno	abnormal melanosome morphology	HPS4 VPS33A KIT LYST	2.23e-05	44	53	4	MP:0005075
MousePheno	abnormal melanosome size	VPS33A LYST	4.22e-05	3	53	2	MP:0030916
MousePheno	abnormal melanocyte morphology	HPS4 VPS33A KIT LYST	8.19e-05	61	53	4	MP:0002877
MousePheno	diluted coat color	HPS4 VPS33A KIT LYST	9.89e-05	64	53	4	MP:0000371
MousePheno	abnormal ear pigmentation	HPS4 KIT LYST	1.26e-04	26	53	3	MP:0000015
MousePheno	abnormal outer ear skin morphology	HPS4 KIT LYST	1.41e-04	27	53	3	MP:0030530
MousePheno	abnormal head skin morphology	HPS4 KIT LYST	2.83e-04	34	53	3	MP:0030529
MousePheno	decreased lysosomal enzyme secretion	HPS4 LYST	2.93e-04	7	53	2	MP:0003173
MousePheno	increased bleeding time	HPS4 VPS33A KIT LYST	3.86e-04	91	53	4	MP:0005606
MousePheno	dilated sarcoplasmic reticulum	CACNA1S KLHL31	3.89e-04	8	53	2	MP:0004089
MousePheno	decreased cardiomyocyte apoptosis	MAPK8 MAPK9	3.89e-04	8	53	2	MP:0003223
MousePheno	enhanced coordination	ABCA2 FOLH1 LRRK2	3.95e-04	38	53	3	MP:0003858
Domain	MAPK_JNK	MAPK8 MAPK9 MAPK10	5.24e-07	5	71	3	IPR008351
Domain	ARM-type_fold	MROH9 KIFAP3 ZYG11A DOHH NBEAL1 LRRK2 MROH5 ARMH1 LYST	5.32e-06	339	71	9	IPR016024
Domain	MAP_kinase_CS	MAPK8 MAPK9 MAPK10	1.13e-05	12	71	3	IPR003527
Domain	MAPK	MAPK8 MAPK9 MAPK10	1.13e-05	12	71	3	PS01351
Domain	-	MROH9 KIFAP3 ZYG11A DOHH LRRK2 MROH5 ARMH1	2.13e-05	222	71	7	1.25.10.10
Domain	ARM-like	MROH9 KIFAP3 ZYG11A DOHH LRRK2 MROH5 ARMH1	7.37e-05	270	71	7	IPR011989
Domain	Olfact_rcpt	OR8H2 OR4C3 OR6C1 OR6C3 OR1F2P OR5A2 OR51G1 OR8G2P	1.20e-04	393	71	8	IPR000725
Domain	PH_BEACH	NBEAL1 LYST	2.12e-04	6	71	2	PF14844
Domain	SWIM	ZSWIM2 ZSWIM7	2.96e-04	7	71	2	PF04434
Domain	PH-BEACH_dom	NBEAL1 LYST	3.93e-04	8	71	2	IPR023362
Domain	-	NBEAL1 LYST	3.93e-04	8	71	2	2.30.29.40
Domain	PH_BEACH	NBEAL1 LYST	3.93e-04	8	71	2	PS51783
Domain	BEACH_dom	NBEAL1 LYST	5.04e-04	9	71	2	IPR000409
Domain	BEACH	NBEAL1 LYST	5.04e-04	9	71	2	PS50197
Domain	Beach	NBEAL1 LYST	5.04e-04	9	71	2	PF02138
Domain	-	NBEAL1 LYST	5.04e-04	9	71	2	1.10.1540.10
Domain	Znf_SWIM	ZSWIM2 ZSWIM7	5.04e-04	9	71	2	IPR007527
Domain	Beach	NBEAL1 LYST	5.04e-04	9	71	2	SM01026
Domain	ZF_SWIM	ZSWIM2 ZSWIM7	5.04e-04	9	71	2	PS50966
Domain	BTB-kelch_protein	ENC1 KLHL31 KLHL22	5.83e-04	43	71	3	IPR017096
Domain	6PGD_dom_2	HADHA PGD	6.29e-04	10	71	2	IPR013328
Domain	Amidohydro_1	GDA DPYS	6.29e-04	10	71	2	PF01979
Domain	Metal-dep_hydrolase_composite	GDA DPYS	6.29e-04	10	71	2	IPR011059
Domain	-	HADHA PGD	6.29e-04	10	71	2	1.10.1040.10
Domain	Amidohydro-rel	GDA DPYS	7.66e-04	11	71	2	IPR006680
Domain	7tm_1	OR8H2 OR4C3 MAS1L OR6C1 OR6C3 OR1F2P OR5A2 OR51G1 OR8G2P	1.02e-03	677	71	9	PF00001
Domain	G_PROTEIN_RECEP_F1_1	OR8H2 OR4C3 MAS1L OR6C1 OR6C3 OR1F2P OR5A2 OR51G1 OR8G2P	1.11e-03	685	71	9	PS00237
Domain	G_PROTEIN_RECEP_F1_2	OR8H2 OR4C3 MAS1L OR6C1 OR6C3 OR1F2P OR5A2 OR51G1 OR8G2P	1.18e-03	691	71	9	PS50262
Domain	GPCR_Rhodpsn	OR8H2 OR4C3 MAS1L OR6C1 OR6C3 OR1F2P OR5A2 OR51G1 OR8G2P	1.19e-03	692	71	9	IPR000276
Domain	Kelch	ENC1 KLHL31 KLHL22	1.40e-03	58	71	3	SM00612
Domain	Gal_Oxase/kelch_b-propeller	ENC1 KLHL31 KLHL22	1.47e-03	59	71	3	IPR011043
Domain	BACK	ENC1 KLHL31 KLHL22	1.54e-03	60	71	3	SM00875
Domain	BACK	ENC1 KLHL31 KLHL22	1.62e-03	61	71	3	PF07707
Domain	BACK	ENC1 KLHL31 KLHL22	1.62e-03	61	71	3	IPR011705
Domain	PROTEIN_KINASE_ATP	CDK20 BMPR1B LRRK2 MAPK8 MAPK9 MAPK10 KIT	1.77e-03	459	71	7	PS00107
Domain	6-PGluconate_DH_C-like	HADHA PGD	2.34e-03	19	71	2	IPR008927
Domain	Ser/Thr_kinase_AS	CDK20 BMPR1B LRRK2 MAPK8 MAPK9 MAPK10	2.36e-03	357	71	6	IPR008271
Domain	Kelch_1	ENC1 KLHL31 KLHL22	2.40e-03	70	71	3	PF01344
Domain	Kelch_1	ENC1 KLHL31 KLHL22	2.40e-03	70	71	3	IPR006652
Domain	S_TKc	CDK20 BMPR1B LRRK2 MAPK8 MAPK9 MAPK10	2.42e-03	359	71	6	SM00220
Domain	PROTEIN_KINASE_ST	CDK20 BMPR1B LRRK2 MAPK8 MAPK9 MAPK10	2.53e-03	362	71	6	PS00108
Domain	Prot_kinase_dom	CDK20 BMPR1B LRRK2 MAPK8 MAPK9 MAPK10 KIT	2.53e-03	489	71	7	IPR000719
Domain	PROTEIN_KINASE_DOM	CDK20 BMPR1B LRRK2 MAPK8 MAPK9 MAPK10 KIT	2.65e-03	493	71	7	PS50011
Domain	Pkinase	CDK20 BMPR1B LRRK2 MAPK8 MAPK9 MAPK10	3.25e-03	381	71	6	PF00069
Domain	TPR_REGION	MAU2 CABIN1 INTS8 IFIT1	3.60e-03	165	71	4	PS50293
Domain	TPR	MAU2 CABIN1 INTS8 IFIT1	3.60e-03	165	71	4	PS50005
Domain	Metal_Hydrolase	GDA DPYS	3.73e-03	24	71	2	IPR032466
Pathway	KEGG_MEDICUS_PATHOGEN_HIV_VPR_TAT_TO_TNF_JNK_SIGNALING_PATHWAY	MAPK8 MAPK9 MAPK10	5.28e-07	5	54	3	M47570
Pathway	KEGG_MEDICUS_ENV_FACTOR_PARAQUAT_TO_FAS_JNK_SIGNALING_PATHWAY	MAPK8 MAPK9 MAPK10	5.28e-07	5	54	3	M49021
Pathway	KEGG_MEDICUS_PATHOGEN_HTLV_1_TAX_TO_TNF_JNK_SIGNALING_PATHWAY	MAPK8 MAPK9 MAPK10	5.28e-07	5	54	3	M49005
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_HTT_TO_TNF_JNK_SIGNALING_PATHWAY	MAPK8 MAPK9 MAPK10	1.05e-06	6	54	3	M47680
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_IRE1A_JNK_SIGNALING_PATHWAY	MAPK8 MAPK9 MAPK10	1.05e-06	6	54	3	M47698
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_DJ1_TO_FAS_JNK_SIGNALING_PATWHAY	MAPK8 MAPK9 MAPK10	1.05e-06	6	54	3	M47712
Pathway	KEGG_MEDICUS_REFERENCE_IRE1A_JNK_SIGNALING_PATHWAY	MAPK8 MAPK9 MAPK10	1.84e-06	7	54	3	M47697
Pathway	KEGG_MEDICUS_REFERENCE_FAS_JNK_SIGNALING_PATHWAY	MAPK8 MAPK9 MAPK10	1.84e-06	7	54	3	M47711
Pathway	KEGG_MEDICUS_ENV_FACTOR_METALS_TO_JNK_SIGNALING_PATHWAY	MAPK8 MAPK9 MAPK10	2.94e-06	8	54	3	M47814
Pathway	WP_CANNABINOID_RECEPTOR_SIGNALING	DAGLB MAPK8 MAPK9 MAPK10	4.25e-06	29	54	4	M39676
Pathway	REACTOME_ACTIVATION_OF_THE_AP_1_FAMILY_OF_TRANSCRIPTION_FACTORS	MAPK8 MAPK9 MAPK10	6.26e-06	10	54	3	MM15135
Pathway	REACTOME_ACTIVATION_OF_THE_AP_1_FAMILY_OF_TRANSCRIPTION_FACTORS	MAPK8 MAPK9 MAPK10	6.26e-06	10	54	3	M13962
Pathway	KEGG_MEDICUS_REFERENCE_MLK_JNK_SIGNALING_PATHWAY	MAPK8 MAPK9 MAPK10	1.14e-05	12	54	3	M47929
Pathway	KEGG_MEDICUS_REFERENCE_EGF_EGFR_RAS_JNK_SIGNALING_PATHWAY	MAPK8 MAPK9 MAPK10	1.48e-05	13	54	3	M47594
Pathway	KEGG_MEDICUS_REFERENCE_TNF_JNK_SIGNALING_PATHWAY	MAPK8 MAPK9 MAPK10	2.87e-05	16	54	3	M47569
Pathway	KEGG_MEDICUS_REFERENCE_IL1_IL1R_JNK_SIGNALING_PATHWAY	MAPK8 MAPK9 MAPK10	4.93e-05	19	54	3	M47471
Pathway	KEGG_MEDICUS_REFERENCE_REGULATION_OF_GF_RTK_RAS_ERK_SIGNALING_PTP	MAPK8 MAPK9 MAPK10	5.78e-05	20	54	3	M47928
Pathway	REACTOME_JNK_C_JUN_KINASES_PHOSPHORYLATION_AND_ACTIVATION_MEDIATED_BY_ACTIVATED_HUMAN_TAK1	MAPK8 MAPK9 MAPK10	7.77e-05	22	54	3	M859
Pathway	REACTOME_JNK_C_JUN_KINASES_PHOSPHORYLATION_AND_ACTIVATION_MEDIATED_BY_ACTIVATED_HUMAN_TAK1	MAPK8 MAPK9 MAPK10	8.91e-05	23	54	3	MM15134
Pathway	REACTOME_CELLULAR_SENESCENCE	MRE11 MAPK8 MAPK9 MAPK10 CABIN1	8.95e-05	119	54	5	MM14901
Pathway	KEGG_MEDICUS_REFERENCE_TLR2_4_MAPK_SIGNALING_PATHWAY	MAPK8 MAPK9 MAPK10	1.30e-04	26	54	3	M47565
Pathway	WP_NANOPARTICLEMEDIATED_ACTIVATION_OF_RECEPTOR_SIGNALING	MAPK8 MAPK9 MAPK10	1.63e-04	28	54	3	M39572
Pathway	REACTOME_MAPK_TARGETS_NUCLEAR_EVENTS_MEDIATED_BY_MAP_KINASES	MAPK8 MAPK9 MAPK10	1.63e-04	28	54	3	MM15132
Pathway	KEGG_MEDICUS_PATHOGEN_KSHV_VGPCR_TO_GNB_G_PI3K_JNK_SIGNALING_PATHWAY	MAPK8 MAPK9 MAPK10	1.81e-04	29	54	3	M47466
Pathway	REACTOME_MAPK_TARGETS_NUCLEAR_EVENTS_MEDIATED_BY_MAP_KINASES	MAPK8 MAPK9 MAPK10	2.21e-04	31	54	3	M15195
Pathway	PID_NEPHRIN_NEPH1_PATHWAY	MAPK8 MAPK9 MAPK10	2.21e-04	31	54	3	M193
Pathway	PID_CD40_PATHWAY	MAPK8 MAPK9 MAPK10	2.21e-04	31	54	3	M45
Pathway	PID_WNT_NONCANONICAL_PATHWAY	MAPK8 MAPK9 MAPK10	2.44e-04	32	54	3	M23
Pathway	WP_13Q1212_COPY_NUMBER_VARIATION	SACS MAPK8 MAPK9	2.92e-04	34	54	3	M48103
Pathway	SIG_CD40PATHWAYMAP	MAPK8 MAPK9 MAPK10	2.92e-04	34	54	3	M12705
Pathway	WP_WNT_SIGNALING_IN_KIDNEY_DISEASE	MAPK8 MAPK9 MAPK10	3.47e-04	36	54	3	M39699
Pathway	WP_HOSTPATHOGEN_INTERACTION_OF_HUMAN_CORONAVIRUSES_MAPK_SIGNALING	MAPK8 MAPK9 MAPK10	3.47e-04	36	54	3	M39908
Pathway	WP_NEOVASCULARIZATION_PROCESSES	MAPK8 MAPK9 KIT	3.76e-04	37	54	3	M39506
Pathway	REACTOME_OXIDATIVE_STRESS_INDUCED_SENESCENCE	MAPK8 MAPK9 MAPK10	3.76e-04	37	54	3	MM14899
Pathway	PID_FAS_PATHWAY	MAPK8 MAPK9 MAPK10	4.08e-04	38	54	3	M94
Pathway	KEGG_GNRH_SIGNALING_PATHWAY	CACNA1S MAPK8 MAPK9 MAPK10	5.96e-04	101	54	4	M1979
Pathway	PID_ERBB2_ERBB3_PATHWAY	MAPK8 MAPK9 MAPK10	6.30e-04	44	54	3	M175
Pathway	WP_WNT_SIGNALING_IN_KIDNEY_DISEASE	MAPK8 MAPK9 MAPK10	6.30e-04	44	54	3	MM15878
Pathway	KEGG_OLFACTORY_TRANSDUCTION	OR8H2 OR4C3 OR6C1 OR6C3 OR5A2 OR51G1 OR8G2P	6.68e-04	389	54	7	M14091
Pathway	WP_TRANSLATION_INHIBITORS_IN_CHRONICALLY_ACTIVATED_PDGFRA_CELLS	MAPK8 MAPK9 MAPK10	7.18e-04	46	54	3	M39805
Pathway	KEGG_TYPE_II_DIABETES_MELLITUS	MAPK8 MAPK9 MAPK10	7.65e-04	47	54	3	M19708
Pathway	WP_MECHANOREGULATION_AND_PATHOLOGY_OF_YAPTAZ_VIA_HIPPO_AND_NONHIPPO_MECHANISMS	MAPK8 MAPK9 MAPK10	7.65e-04	47	54	3	M39829
Pathway	WP_INTERLEUKIN1_IL1_STRUCTURAL_PATHWAY	MAPK8 MAPK9 MAPK10	8.64e-04	49	54	3	M39543
Pathway	PID_FOXO_PATHWAY	MAPK8 MAPK9 MAPK10	8.64e-04	49	54	3	M136
Pathway	REACTOME_CELLULAR_SENESCENCE	MRE11 MAPK8 MAPK9 MAPK10 CABIN1	9.19e-04	197	54	5	M27188
Pathway	WP_OSTEOBLAST_DIFFERENTIATION_AND_RELATED_DISEASES	BMPR1B MAPK8 MAPK9 MAPK10	1.07e-03	118	54	4	M39852
Pathway	PID_NFAT_3PATHWAY	MAPK8 MAPK9 CABIN1	1.09e-03	53	54	3	M113
Pathway	REACTOME_INTERLEUKIN_17_SIGNALING	MAPK8 MAPK9 MAPK10	1.48e-03	59	54	3	MM15128
Pathway	WP_NOVEL_INTRACELLULAR_COMPONENTS_OF_RIGILIKE_RECEPTOR_PATHWAY	MAPK8 MAPK9 MAPK10	1.56e-03	60	54	3	M39583
Pathway	REACTOME_FCERI_MEDIATED_MAPK_ACTIVATION	MAPK8 MAPK9 MAPK10	1.56e-03	60	54	3	MM14913
Pathway	KEGG_COLORECTAL_CANCER	MAPK8 MAPK9 MAPK10	1.71e-03	62	54	3	M14631
Pathway	KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY	MAPK8 MAPK9 MAPK10	1.71e-03	62	54	3	M15569
Pathway	WP_CANONICAL_AND_NONCANONICAL_TGFB_SIGNALING	MAPK8 MAPK9	1.89e-03	17	54	2	M39686
Pathway	WP_AGERAGE_PATHWAY	MAPK8 MAPK9 ALPL	2.05e-03	66	54	3	M39420
Pathway	KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY	MAPK8 MAPK9 MAPK10	2.14e-03	67	54	3	M10462
Pathway	WP_BRAINDERIVED_NEUROTROPHIC_FACTOR_BDNF_SIGNALING	MAPK8 MAPK9 MAPK10 ALPL	2.22e-03	144	54	4	M39691
Pathway	KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	MAPK8 MAPK9 MAPK10	2.23e-03	68	54	3	M16848
Pathway	PID_P75_NTR_PATHWAY	MAPK8 MAPK9 MAPK10	2.23e-03	68	54	3	M153
Pathway	BIOCARTA_ATM_PATHWAY	MRE11 MAPK8	2.36e-03	19	54	2	MM1351
Pathway	KEGG_PANCREATIC_CANCER	MAPK8 MAPK9 MAPK10	2.43e-03	70	54	3	M9726
Pathway	WP_MAPK_SIGNALING	CACNA1S LRRK2 MAPK8 MAPK9 MAPK10	2.45e-03	246	54	5	M39597
Pathway	REACTOME_INTERLEUKIN_17_SIGNALING	MAPK8 MAPK9 MAPK10	2.53e-03	71	54	3	M27382
Pathway	KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY	MAPK8 MAPK9 MAPK10	2.53e-03	71	54	3	M15913
Pathway	BIOCARTA_ATM_PATHWAY	MRE11 MAPK8	2.62e-03	20	54	2	M10628
Pathway	WP_CHROMOSOMAL_AND_MICROSATELLITE_INSTABILITY_IN_COLORECTAL_CANCER	MAPK8 MAPK9 MAPK10	2.73e-03	73	54	3	M39758
Pathway	BIOCARTA_MAPK_PATHWAY	MAPK8 MAPK9 MAPK10	3.07e-03	76	54	3	MM1433
Pathway	KEGG_BETA_ALANINE_METABOLISM	DPYS HADHA	3.17e-03	22	54	2	M2668
Pathway	WP_REGULATORY_CIRCUITS_OF_STAT3_SIGNALING	MAPK8 MAPK9 MAPK10	3.30e-03	78	54	3	M39824
Pathway	KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY	MAPK8 MAPK9 MAPK10	3.42e-03	79	54	3	M11816
Pathway	BIOCARTA_MAPK_PATHWAY	MAPK8 MAPK9 MAPK10	3.67e-03	81	54	3	M13863
Pathway	PID_REG_GR_PATHWAY	MAPK8 MAPK9 MAPK10	3.80e-03	82	54	3	M115
Pathway	REACTOME_MYD88_MAL_TIRAP_CASCADE_INITIATED_ON_PLASMA_MEMBRANE	MAPK8 MAPK9 MAPK10	4.20e-03	85	54	3	MM14645
Pathway	KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION	MAPK8 MAPK9 MAPK10	4.20e-03	85	54	3	M3578
Pathway	KEGG_ERBB_SIGNALING_PATHWAY	MAPK8 MAPK9 MAPK10	4.49e-03	87	54	3	M12467
Pathway	REACTOME_FCERI_MEDIATED_MAPK_ACTIVATION	MAPK8 MAPK9 MAPK10	4.49e-03	87	54	3	M27205
Pubmed	JNK Isoforms Are Involved in the Control of Adult Hippocampal Neurogenesis in Mice, Both in Physiological Conditions and in an Experimental Model of Temporal Lobe Epilepsy.	MAPK8 MAPK9 MAPK10	8.51e-09	3	72	3	30685843
Pubmed	JNK1 is required to preserve cardiac function in the early response to pressure overload.	MAPK8 MAPK9 MAPK10	8.51e-09	3	72	3	16579967
Pubmed	Specific pathophysiological functions of JNK isoforms in the brain.	MAPK8 MAPK9 MAPK10	8.51e-09	3	72	3	15673436
Pubmed	Activation of c-Jun N-terminal kinase mediates gp120IIIB- and nucleoside analogue-induced sensory neuron toxicity.	MAPK8 MAPK9 MAPK10	8.51e-09	3	72	3	15246824
Pubmed	Inhibition of c-Jun NH2-terminal kinase stimulates mu opioid receptor expression via p38 MAPK-mediated nuclear NF-κB activation in neuronal and non-neuronal cells.	MAPK8 MAPK9 MAPK10	8.51e-09	3	72	3	23485395
Pubmed	A critical role of neural-specific JNK3 for ischemic apoptosis.	MAPK8 MAPK9 MAPK10	8.51e-09	3	72	3	14657393
Pubmed	SAPKgamma/JNK1 and SAPKalpha/JNK2 mRNA transcripts are expressed in early gestation human placenta and mouse eggs, preimplantation embryos, and trophoblast stem cells.	MAPK8 MAPK9 MAPK10	8.51e-09	3	72	3	15474087
Pubmed	Disruption of JNK2 decreases the cytokine response to Plasmodium falciparum glycosylphosphatidylinositol in vitro and confers protection in a cerebral malaria model.	MAPK8 MAPK9 MAPK10	8.51e-09	3	72	3	17056565
Pubmed	The Roles of c-Jun N-Terminal Kinase (JNK) in Infectious Diseases.	MAPK8 MAPK9 MAPK10	8.51e-09	3	72	3	34502556
Pubmed	c-Jun N-terminal kinases (JNK) antagonize cardiac growth through cross-talk with calcineurin-NFAT signaling.	MAPK8 MAPK9 MAPK10	8.51e-09	3	72	3	14517246
Pubmed	Knockout of c-Jun N-terminal kinases 1, 2 or 3 isoforms induces behavioural changes.	MAPK8 MAPK9 MAPK10	8.51e-09	3	72	3	23428746
Pubmed	Hippocampal c-Jun-N-terminal kinases serve as negative regulators of associative learning.	MAPK8 MAPK9 MAPK10	8.51e-09	3	72	3	20926661
Pubmed	JNK3 is abundant in insulin-secreting cells and protects against cytokine-induced apoptosis.	MAPK8 MAPK9 MAPK10	8.51e-09	3	72	3	19609503
Pubmed	Platelet storage pool deficiency in mouse pigment mutations associated with seven distinct genetic loci.	HPS4 VPS33A KIT LYST	2.26e-08	15	72	4	6696991
Pubmed	Phosphorylation of microtubule-associated protein tau by isoforms of c-Jun N-terminal kinase (JNK).	MAPK8 MAPK9 MAPK10	3.40e-08	4	72	3	15228592
Pubmed	JNK-mediated BIM phosphorylation potentiates BAX-dependent apoptosis.	MAPK8 MAPK9 MAPK10	3.40e-08	4	72	3	12818176
Pubmed	JNK1, JNK2, and JNK3 are involved in P-glycoprotein-mediated multidrug resistance of hepatocellular carcinoma cells.	MAPK8 MAPK9 MAPK10	3.40e-08	4	72	3	20525557
Pubmed	c-JUN N-terminal kinase-1 (JNK1) but not JNK2 or JNK3 is involved in UV signal transduction in human epidermis.	MAPK8 MAPK9 MAPK10	3.40e-08	4	72	3	16824735
Pubmed	Neuronal c-Jun is required for successful axonal regeneration, but the effects of phosphorylation of its N-terminus are moderate.	MAPK8 MAPK9 MAPK10	3.40e-08	4	72	3	22372722
Pubmed	JNK1, JNK2 and JNK3 are p53 N-terminal serine 34 kinases.	MAPK8 MAPK9 MAPK10	3.40e-08	4	72	3	9393873
Pubmed	Characterization of a novel human sperm-associated antigen 9 (SPAG9) having structural homology with c-Jun N-terminal kinase-interacting protein.	MAPK8 MAPK9 MAPK10	3.40e-08	4	72	3	15693750
Pubmed	A novel Jun N-terminal kinase (JNK)-binding protein that enhances the activation of JNK by MEK kinase 1 and TGF-beta-activated kinase 1.	MAPK8 MAPK9 MAPK10	3.40e-08	4	72	3	10471813
Pubmed	c-Jun N-terminal kinase 3 deficiency protects neurons from axotomy-induced death in vivo through mechanisms independent of c-Jun phosphorylation.	MAPK8 MAPK9 MAPK10	3.40e-08	4	72	3	15528206
Pubmed	A selective small-molecule inhibitor of c-Jun N-terminal kinase 1.	MAPK8 MAPK9 MAPK10	3.40e-08	4	72	3	19527717
Pubmed	APP upregulation contributes to retinal ganglion cell degeneration via JNK3.	MAPK8 MAPK9 MAPK10	3.40e-08	4	72	3	29238071
Pubmed	Cortical interneurons require Jnk1 to enter and navigate the developing cerebral cortex.	MAPK8 MAPK9 MAPK10	3.40e-08	4	72	3	24899703
Pubmed	JNK1 controls mast cell degranulation and IL-1{beta} production in inflammatory arthritis.	MAPK8 MAPK9 KIT	3.40e-08	4	72	3	21135226
Pubmed	JNK-mediated induction of cyclooxygenase 2 is required for neurodegeneration in a mouse model of Parkinson's disease.	MAPK8 MAPK9 MAPK10	8.48e-08	5	72	3	14704277
Pubmed	The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development.	MAPK8 MAPK9 MAPK10	8.48e-08	5	72	3	10230788
Pubmed	The lectin jacalin induces phosphorylation of ERK and JNK in CD4+ T cells.	MAPK8 MAPK9 MAPK10	8.48e-08	5	72	3	12714584
Pubmed	Human immunodeficiency virus type 1 and its coat protein gp120 induce apoptosis and activate JNK and ERK mitogen-activated protein kinases in human neurons.	MAPK8 MAPK9 MAPK10	8.48e-08	5	72	3	9403476
Pubmed	Distinct roles of c-Jun N-terminal kinase isoforms in neurite initiation and elongation during axonal regeneration.	MAPK8 MAPK9 MAPK10	8.48e-08	5	72	3	20534829
Pubmed	JNK regulates the photic response of the mammalian circadian clock.	MAPK8 MAPK9 MAPK10	8.48e-08	5	72	3	22441692
Pubmed	gp160 of HIV or anti-CD4 monoclonal antibody ligation of CD4 induces inhibition of JNK and ERK-2 activities in human peripheral CD4+ T lymphocytes.	MAPK8 MAPK9 MAPK10	8.48e-08	5	72	3	9045910
Pubmed	JNK signaling is required for proper tangential migration and laminar allocation of cortical interneurons.	MAPK8 MAPK9 MAPK10	1.69e-07	6	72	3	31915148
Pubmed	HMGB1 is phosphorylated by classical protein kinase C and is secreted by a calcium-dependent mechanism.	MAPK8 MAPK9 MAPK10	1.69e-07	6	72	3	19380828
Pubmed	HIV-1 gp120 and chemokine activation of Pyk2 and mitogen-activated protein kinases in primary macrophages mediated by calcium-dependent, pertussis toxin-insensitive chemokine receptor signaling.	MAPK8 MAPK9 MAPK10	1.69e-07	6	72	3	11698270
Pubmed	NGF controls APP cleavage by downregulating APP phosphorylation at Thr668: relevance for Alzheimer's disease.	MAPK8 MAPK9 MAPK10	1.69e-07	6	72	3	27076121
Pubmed	Neuroprotection by histone deacetylase-related protein.	MAPK8 MAPK9 MAPK10	1.69e-07	6	72	3	16611996
Pubmed	c-Jun N-terminal kinase 1 phosphorylates Myt1 to prevent UVA-induced skin cancer.	MAPK8 MAPK9 MAPK10	1.69e-07	6	72	3	19204086
Pubmed	A new c-Jun N-terminal kinase (JNK)-interacting protein, Sab (SH3BP5), associates with mitochondria.	MAPK8 MAPK9 MAPK10	1.69e-07	6	72	3	12167088
Pubmed	JNK-mediated phosphorylation of DLK suppresses its ubiquitination to promote neuronal apoptosis.	MAPK8 MAPK9 MAPK10	2.96e-07	7	72	3	23979718
Pubmed	Phosphorylation-dependent scaffolding role of JSAP1/JIP3 in the ASK1-JNK signaling pathway. A new mode of regulation of the MAP kinase cascade.	MAPK8 MAPK9 MAPK10	2.96e-07	7	72	3	12189133
Pubmed	Crosstalk of MAP3K1 and EGFR signaling mediates gene-environment interactions that block developmental tissue closure.	MAPK8 MAPK9 MAPK10	2.96e-07	7	72	3	38897570
Pubmed	Activation of mitogen activated protein kinases via complement receptor type 2.	MAPK8 MAPK9 MAPK10	2.96e-07	7	72	3	15603708
Pubmed	HIV-1 glycoprotein 120 induces the MMP-9 cytopathogenic factor production that is abolished by inhibition of the p38 mitogen-activated protein kinase signaling pathway.	MAPK8 MAPK9 MAPK10	2.96e-07	7	72	3	11468147
Pubmed	p38 MAPK signalling cascades: ancient roles and new functions.	MAPK8 MAPK9 MAPK10	2.96e-07	7	72	3	10878576
Pubmed	HIV-1 gp120 chemokine receptor-mediated signaling in human macrophages.	MAPK8 MAPK9 MAPK10	2.96e-07	7	72	3	12857973
Pubmed	Hyperphosphorylation of the retinoid X receptor alpha by activated c-Jun NH2-terminal kinases.	MAPK8 MAPK9 MAPK10	2.96e-07	7	72	3	10383391
Pubmed	Selective interaction of JNK protein kinase isoforms with transcription factors.	MAPK8 MAPK9 MAPK10	4.73e-07	8	72	3	8654373
Pubmed	JSAP1, a novel jun N-terminal protein kinase (JNK)-binding protein that functions as a Scaffold factor in the JNK signaling pathway.	MAPK8 MAPK9 MAPK10	7.08e-07	9	72	3	10523642
Pubmed	Suppression of ischemia in arterial occlusive disease by JNK-promoted native collateral artery development.	MAPK8 MAPK9 MAPK10	1.01e-06	10	72	3	27504807
Pubmed	IAP suppression of apoptosis involves distinct mechanisms: the TAK1/JNK1 signaling cascade and caspase inhibition.	MAPK8 MAPK9 MAPK10	1.01e-06	10	72	3	11865055
Pubmed	Interaction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3.	MAPK8 MAPK9 MAPK10	1.01e-06	10	72	3	10629060
Pubmed	A docking site in MKK4 mediates high affinity binding to JNK MAPKs and competes with similar docking sites in JNK substrates.	MAPK8 MAPK9 MAPK10	1.01e-06	10	72	3	12788955
Pubmed	JNK initiates a cytokine cascade that causes Pax2 expression and closure of the optic fissure.	MAPK8 MAPK9 MAPK10	1.01e-06	10	72	3	12756228
Pubmed	The c-Jun NH2-terminal kinase is essential for epidermal growth factor expression during epidermal morphogenesis.	MAPK8 MAPK9 MAPK10	1.01e-06	10	72	3	15375216
Pubmed	Genetic interactions between Brca1 and Gadd45a in centrosome duplication, genetic stability, and neural tube closure.	MAPK8 MAPK9 MAPK10	1.39e-06	11	72	3	15123655
Pubmed	Effects of SDF-1alpha and gp120IIIB on apoptotic pathways in SK-N-SH neuroblastoma cells.	MAPK8 MAPK9 MAPK10	1.39e-06	11	72	3	16481105
Pubmed	Phosphorylation of GSK-3beta by cGMP-dependent protein kinase II promotes hypertrophic differentiation of murine chondrocytes.	MAPK8 MAPK9 MAPK10	1.39e-06	11	72	3	18551195
Pubmed	Early construction of the thalamocortical axon pathway requires c-Jun N-terminal kinase signaling within the ventral forebrain.	MAPK8 MAPK9 MAPK10	1.39e-06	11	72	3	34494344
Pubmed	Wnt5a is a transcriptional target of Dlx homeogenes and promotes differentiation of interneuron progenitors in vitro and in vivo.	MAPK8 MAPK9 MAPK10	3.05e-06	14	72	3	21325536
Pubmed	Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability.	MAPK8 MAPK9 MAPK10	3.05e-06	14	72	3	19805353
Pubmed	gp120-mediated induction of the MAPK cascade is dependent on the activation state of CD4(+) lymphocytes.	MAPK8 MAPK9 MAPK10	3.05e-06	14	72	3	12239168
Pubmed	HIV envelope gp120 activates human arterial smooth muscle cells.	MAPK8 MAPK9 MAPK10	3.80e-06	15	72	3	11504923
Pubmed	JNK-dependent Stat3 phosphorylation contributes to Akt activation in response to arsenic exposure.	MAPK8 MAPK9	4.23e-06	2	72	2	22696236
Pubmed	C-Jun N-terminal kinase (JNK) isoforms play differing roles in otitis media.	MAPK8 MAPK9	4.23e-06	2	72	2	25311344
Pubmed	Genetic inhibition or activation of JNK1/2 protects the myocardium from ischemia-reperfusion-induced cell death in vivo.	MAPK8 MAPK9	4.23e-06	2	72	2	16043490
Pubmed	Combined Activities of JNK1 and JNK2 in Hepatocytes Protect Against Toxic Liver Injury.	MAPK8 MAPK9	4.23e-06	2	72	2	26708719
Pubmed	Ablation of the spindle assembly checkpoint by a compound targeting Mps1.	MAPK8 MAPK9	4.23e-06	2	72	2	16113653
Pubmed	c-Jun N-terminal kinase 1 is deleterious to the function and survival of murine pancreatic islets.	MAPK8 MAPK9	4.23e-06	2	72	2	18853132
Pubmed	Ultrafine particles from diesel engines induce vascular oxidative stress via JNK activation.	MAPK8 MAPK9	4.23e-06	2	72	2	19154785
Pubmed	Role of the MAPK/cJun NH2-terminal kinase signaling pathway in starvation-induced autophagy.	MAPK8 MAPK9	4.23e-06	2	72	2	29950132
Pubmed	Functional in vivo interactions between JNK1 and JNK2 isoforms in obesity and insulin resistance.	MAPK8 MAPK9	4.23e-06	2	72	2	16818881
Pubmed	Specific role of JNK in the maintenance of the tumor-initiating capacity of A549 human non-small cell lung cancer cells.	MAPK8 MAPK9	4.23e-06	2	72	2	23912840
Pubmed	Suppression of inflammatory cytokine production by carbon monoxide involves the JNK pathway and AP-1.	MAPK8 MAPK9	4.23e-06	2	72	2	12857751
Pubmed	JNK1, but not JNK2, is required in two mechanistically distinct models of inflammatory arthritis.	MAPK8 MAPK9	4.23e-06	2	72	2	21839715
Pubmed	JNK is required for maintaining the tumor-initiating cell-like properties of acquired chemoresistant human cancer cells.	MAPK8 MAPK9	4.23e-06	2	72	2	26235742
Pubmed	Prevention of steatosis by hepatic JNK1.	MAPK8 MAPK9	4.23e-06	2	72	2	19945406
Pubmed	C-Jun NH(2)-terminal kinase mediates proliferation and tumor growth of human prostate carcinoma.	MAPK8 MAPK9	4.23e-06	2	72	2	12538493
Pubmed	Hypothermia attenuates ischemia/reperfusion-induced endothelial cell apoptosis via alterations in apoptotic pathways and JNK signaling.	MAPK8 MAPK9	4.23e-06	2	72	2	19596001
Pubmed	Inhibition of Jun NH2-terminal kinases suppresses the growth of experimental head and neck squamous cell carcinoma.	MAPK8 MAPK9	4.23e-06	2	72	2	17908987
Pubmed	c-Jun N-terminal kinase 1/2 activation by tumor necrosis factor-alpha induces insulin resistance in human visceral but not subcutaneous adipocytes: reversal by liver X receptor agonists.	MAPK8 MAPK9	4.23e-06	2	72	2	19567513
Pubmed	Increased JNK in males compared with females in a rodent model of abdominal aortic aneurysm.	MAPK8 MAPK9	4.23e-06	2	72	2	22316675
Pubmed	Defective antiviral CD8 T-cell response and viral clearance in the absence of c-Jun N-terminal kinases.	MAPK8 MAPK9	4.23e-06	2	72	2	24673683
Pubmed	c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis.	MAPK8 MAPK9	4.23e-06	2	72	2	11435459
Pubmed	[Sodium butyrate do not induce the program of premature senescence in transformants with JNK1,2 knockout].	MAPK8 MAPK9	4.23e-06	2	72	2	19140343
Pubmed	Modulation of the response of prostate cancer cell lines to cisplatin treatment using small interfering RNA.	MAPK8 MAPK9	4.23e-06	2	72	2	23900581
Pubmed	Inhibition of c-Jun N-terminal kinase attenuates low shear stress-induced atherogenesis in apolipoprotein E-deficient mice.	MAPK8 MAPK9	4.23e-06	2	72	2	21629969
Pubmed	c-Jun N-terminal protein kinase 1 (JNK1), but not JNK2, is essential for tumor necrosis factor alpha-induced c-Jun kinase activation and apoptosis.	MAPK8 MAPK9	4.23e-06	2	72	2	15572687
Pubmed	Hepatotoxicity mediated by pyrazole (cytochrome P450 2E1) plus tumor necrosis factor alpha treatment occurs in c-Jun N-terminal kinase 2-/- but not in c-Jun N-terminal kinase 1-/- mice.	MAPK8 MAPK9	4.23e-06	2	72	2	21748763
Pubmed	Purinergic (ATP) signaling stimulates JNK1 but not JNK2 MAPK in osteoblast-like cells: contribution of intracellular Ca2+ release, stress activated and L-voltage-dependent calcium influx, PKC and Src kinases.	MAPK8 MAPK9	4.23e-06	2	72	2	18625195
Pubmed	The JNKs differentially regulate RNA polymerase III transcription by coordinately modulating the expression of all TFIIIB subunits.	MAPK8 MAPK9	4.23e-06	2	72	2	19620725
Pubmed	Tumor necrosis factor-induced toxic liver injury results from JNK2-dependent activation of caspase-8 and the mitochondrial death pathway.	MAPK8 MAPK9	4.23e-06	2	72	2	16571730
Pubmed	JNK inhibition reduces apoptosis and neovascularization in a murine model of age-related macular degeneration.	MAPK8 MAPK9	4.23e-06	2	72	2	23341606
Pubmed	c-Jun N-terminal kinase 2 promotes enterocyte survival and goblet cell differentiation in the inflamed intestine.	MAPK8 MAPK9	4.23e-06	2	72	2	28098247
Pubmed	c-Jun N-terminal kinase is upregulated in patients with hypospadias.	MAPK8 MAPK9	4.23e-06	2	72	2	23273084
Pubmed	An initial phase of JNK activation inhibits cell death early in the endoplasmic reticulum stress response.	MAPK8 MAPK9	4.23e-06	2	72	2	27122189
Pubmed	JNK2 up-regulates hypoxia-inducible factors and contributes to hypoxia-induced erythropoiesis and pulmonary hypertension.	MAPK8 MAPK9	4.23e-06	2	72	2	29118187
Pubmed	Jnk2 deficiency increases the rate of glaucomatous neurodegeneration in ocular hypertensive DBA/2J mice.	MAPK9 MAPK10	4.23e-06	2	72	2	29899326
GeneFamily	Mitogen-activated protein kinases	MAPK8 MAPK9 MAPK10	5.25e-06	13	49	3	651
GeneFamily	Kelch like\|BTB domain containing	ENC1 KLHL31 KLHL22	1.99e-04	42	49	3	617
GeneFamily	Zinc fingers SWIM-type\|Mitogen-activated protein kinase kinase kinases	ZSWIM2 ZSWIM7	2.56e-04	9	49	2	90
GeneFamily	WD repeat domain containing\|BEACH domain containing	NBEAL1 LYST	2.56e-04	9	49	2	1230
GeneFamily	Maestro heat like repeat containing	MROH9 MROH5	3.90e-04	11	49	2	636
GeneFamily	Integrator complex	INTS2 INTS8	7.39e-04	15	49	2	1366
GeneFamily	Basic leucine zipper proteins\|BTB domain containing	ENC1 KLHL31 KLHL22	5.72e-03	134	49	3	861
GeneFamily	Olfactory receptors, family 8	OR8H2 OR8G2P	7.80e-03	49	49	2	155
GeneFamily	DNAJ (HSP40) heat shock proteins\|C2 tensin-type domain containing	SACS DNAJA2	7.80e-03	49	49	2	584
GeneFamily	Olfactory receptors, family 6	OR6C1 OR6C3	8.43e-03	51	49	2	153
ToppCell	Thalamus-Macroglia-CSF_related-EPENDYMAL-Ependymal.Ccdc153_(Ccdc153)-\|Thalamus / BrainAtlas - Mouse McCarroll V32	OTOA DYDC1 ZSWIM2 ARMH1 ZP3	1.63e-06	122	72	5	aca079f2f033cc1ac13c4ee02d490b6a514cbd5c
ToppCell	Thalamus-Macroglia-CSF_related-EPENDYMAL-Ependymal.Ccdc153_(Ccdc153)--\|Thalamus / BrainAtlas - Mouse McCarroll V32	OTOA DYDC1 ZSWIM2 ARMH1 ZP3	1.63e-06	122	72	5	ac38130010f76648757eac700a8039f3960ddde3
ToppCell	Thalamus-Macroglia-CSF_related-EPENDYMAL\|Thalamus / BrainAtlas - Mouse McCarroll V32	OTOA DYDC1 ZSWIM2 ARMH1 ZP3	1.63e-06	122	72	5	7ab0b63244116e74c5783c3293cf08224d094d0a
ToppCell	Thalamus-Macroglia-CSF_related\|Thalamus / BrainAtlas - Mouse McCarroll V32	OTOA DYDC1 ZSWIM2 ARMH1 ZP3	1.63e-06	122	72	5	eb944243424460bf5c66aced3ed7b7a1b6486ac7
ToppCell	Thalamus-Macroglia-CSF_related-EPENDYMAL-Ependymal.Ccdc153_(Ccdc153)\|Thalamus / BrainAtlas - Mouse McCarroll V32	OTOA DYDC1 ZSWIM2 ARMH1 ZP3	1.63e-06	122	72	5	9b0d6b0a394560ff5aadcd3b21519c2393e6def8
ToppCell	3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ZYG11A GDA BMPR1B RNF152 ALPL	8.04e-06	169	72	5	40b557549fe08c5dc9dba359af35993d68d1640a
ToppCell	droplet-Marrow-nan-3m-Hematologic-proerythroblast\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GDA LRRK2 ELP1 PGD LYST	8.76e-06	172	72	5	cfcfa7eeff1805bedf10a3c07826459914c3e872
ToppCell	droplet-Lung-nan-21m-Epithelial-Ciliated_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DYDC1 ARMH1 ZP3 DNAH6 FBXO15	9.53e-06	175	72	5	3ed22ea41810e73c02db4f2d03745e4ce7e43bb1
ToppCell	droplet-Lung-nan-21m-Epithelial-ciliated_columnar_cell_of_tracheobronchial_tree\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DYDC1 ARMH1 ZP3 DNAH6 FBXO15	9.53e-06	175	72	5	8fb1e5f6aa68274adf322401db8c7b80e8c554d7
ToppCell	Severe-B_intermediate-6\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	DUS2 SACS ENC1 LRRK2 FXYD1	1.73e-05	198	72	5	8402421dc060926e968efe39a4e907f1e8ae5b1f
ToppCell	Substantia_nigra-Macroglia-CSF_related\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	DYDC1 ARMH1 ZP3 DNAH6	7.01e-05	136	72	4	47663c5d81c766a333207a44fc5b58b07309ee76
ToppCell	Substantia_nigra-Macroglia-CSF_related-EPENDYMAL-Ependyma.Ccdc153_(Ccdc153)--\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	DYDC1 ARMH1 ZP3 DNAH6	7.01e-05	136	72	4	6d2e5b871f4cf8d64e6fe0be666fb3490797c635
ToppCell	Substantia_nigra-Macroglia-CSF_related-EPENDYMAL-Ependyma.Ccdc153_(Ccdc153)\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	DYDC1 ARMH1 ZP3 DNAH6	7.01e-05	136	72	4	fd4269d194c7c11c6ab4383393a01efab05cbace
ToppCell	Substantia_nigra-Macroglia-CSF_related-EPENDYMAL\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	DYDC1 ARMH1 ZP3 DNAH6	7.01e-05	136	72	4	3f6cec8d52c84191f7f6e2dd4dc47524dfd5b21b
ToppCell	Substantia_nigra-Macroglia-CSF_related-EPENDYMAL-Ependyma.Ccdc153_(Ccdc153)-\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	DYDC1 ARMH1 ZP3 DNAH6	7.01e-05	136	72	4	67d736096d6b6ddb4722809557f5e987063b8d23
ToppCell	Cerebellum-Macroglia-CSF_related\|Cerebellum / BrainAtlas - Mouse McCarroll V32	ZSWIM2 ARMH1 ZP3 KLHL31	7.21e-05	137	72	4	f004199b654143e9e766e5c5f56858089e98cf5f
ToppCell	Cerebellum-Macroglia-CSF_related-CHOROID_PLEXUS-Choroid_Plexus.Ttr_(Ttr)--\|Cerebellum / BrainAtlas - Mouse McCarroll V32	ZSWIM2 ARMH1 ZP3 KLHL31	7.21e-05	137	72	4	6a5599af9d0ee1be6cac17af09aa4cd50774c683
ToppCell	Cerebellum-Macroglia-CSF_related-CHOROID_PLEXUS-Choroid_Plexus.Ttr_(Ttr)-\|Cerebellum / BrainAtlas - Mouse McCarroll V32	ZSWIM2 ARMH1 ZP3 KLHL31	7.21e-05	137	72	4	01cbc9082e10ef51a1763a8b2d708eea0434490f
ToppCell	Cerebellum-Macroglia-CSF_related-CHOROID_PLEXUS-Choroid_Plexus.Ttr_(Ttr)\|Cerebellum / BrainAtlas - Mouse McCarroll V32	ZSWIM2 ARMH1 ZP3 KLHL31	7.21e-05	137	72	4	a22730b6f78b66bb3c46155af37c34e554672dee
ToppCell	Cerebellum-Macroglia-CSF_related-CHOROID_PLEXUS\|Cerebellum / BrainAtlas - Mouse McCarroll V32	ZSWIM2 ARMH1 ZP3 KLHL31	7.21e-05	137	72	4	ce7c57dad201bd2164fc8b1172aca709f3f7def2
ToppCell	Posterior_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_1\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	GDA ENC1 MROH5 TMPRSS7	8.51e-05	143	72	4	5fb5a4ea93e5cce55d427e3b4a50a979504fad3c
ToppCell	Hippocampus-Macroglia-CSF_related\|Hippocampus / BrainAtlas - Mouse McCarroll V32	DYDC1 ARMH1 ZP3 DNAH6	1.08e-04	152	72	4	c2b6cc41546cbd46b9ea5d28a7c66f6330a27df2
ToppCell	droplet-Lung-3m-Hematologic-myeloid-neutrophil-neutrophil\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	GDA ELP1 PGD LYST	1.11e-04	153	72	4	ce6e462ce4dbaf9d265f1f9e2f791efbba8c1dd0
ToppCell	droplet-Lung-3m-Hematologic-myeloid-neutrophil\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	GDA ELP1 PGD LYST	1.11e-04	153	72	4	9dba38574908f31a1194b8a339868f5e4be1be71
ToppCell	Control-Epithelial_airway-Ciliated_cells-Ciliated\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DYDC1 CATIP DNAH6 FBXO15	1.13e-04	154	72	4	4e3bc24043144143842627cacf6f90dda2228910
ToppCell	Control-Epithelial_airway-Ciliated_cells\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DYDC1 CATIP DNAH6 FBXO15	1.13e-04	154	72	4	7556a4b2b062da5ae7ec2bbb66e745e7662db628
ToppCell	PBMC-Control-Myeloid-Neutrophil-Neutrophil-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	BMPR1B SLC2A14 IFIT1 ALPL	1.31e-04	160	72	4	70f3637dd0bcfcef421aa114f946fff0048f192e
ToppCell	15-Distal-Epithelial-Multiciliated_precursor\|Distal / Age, Tissue, Lineage and Cell class	MROH9 DYDC1 CATIP FBXO15	1.55e-04	167	72	4	442ea71a581ed5a547a214132b9f1b0243fd0895
ToppCell	facs-Marrow-Granulocytes-3m-Myeloid-granulocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GDA LRRK2 PGD LYST	1.69e-04	171	72	4	ab21f20ec041cbaacccbd7da4dccdb77ec8bc5c6
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ZYG11A GDA DPYS RNF152	1.69e-04	171	72	4	f5014e3c387fe3118944af392abe10d6b9b0abab
ToppCell	facs-Marrow-Granulocytes-3m-Myeloid-granulocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GDA LRRK2 PGD LYST	1.69e-04	171	72	4	97ad2cfff568a9d006ab1d2e6e00946ee4e3beb3
ToppCell	droplet-Lung-21m-Epithelial-airway_epithelial\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DYDC1 CATIP ARMH1 DNAH6	1.77e-04	173	72	4	a809be2630d2b91b53b82b5e2bb99e05524597c1
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ZYG11A GDA DPYS RNF152	1.77e-04	173	72	4	8888434641ea554a9b62c436e87920378eef29cd
ToppCell	PND07-28-samps-Epithelial-Epithelial-non_alveolar-Ciliated_cell_of_lung_parenchyma\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	DYDC1 CATIP ARMH1 DNAH6	1.81e-04	174	72	4	f41d05a3703d7092bd3c4a97c15ae13069aaa4ad
ToppCell	PND07-28-samps-Epithelial-Epithelial-non_alveolar\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	DYDC1 CATIP ARMH1 DNAH6	1.85e-04	175	72	4	c01a15b2084da4a18f8ff3623f44eb9dfe499f10
ToppCell	COVID-19-kidney-Distal_Epi_Doublet_(PCT)\|kidney / Disease (COVID-19 only), tissue and cell type	GDA DPYS BMPR1B MAPK10	1.89e-04	176	72	4	36f77d878a53b30465b0dea8333a3865dba75613
ToppCell	droplet-Lung-21m-Epithelial-airway_epithelial-lung_ciliated_cell\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DYDC1 CATIP ARMH1 DNAH6	1.93e-04	177	72	4	d947ba38db1772fc5fdcdc211f7511c4aa699dee
ToppCell	droplet-Lung-21m-Epithelial-airway_epithelial-lung_ciliated_cell-ciliated_cell\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DYDC1 CATIP ARMH1 DNAH6	1.93e-04	177	72	4	d5640f0097878f0dac671e51dc51310278bb2682
ToppCell	droplet-Limb_Muscle-MUSCLE-30m\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NBEAL1 VPS13C IFIT1 LYST	1.98e-04	178	72	4	01dafd19de04eff459253eaa9a35debf8f3deedf
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ZYG11A GDA DPYS RNF152	2.06e-04	180	72	4	f8bdfd7bf7b3d52c659a29d8f5f80858e79da83e
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ZYG11A GDA DPYS RNF152	2.06e-04	180	72	4	1363b3254470f6ff98630d1df83a1bdbacc137e0
ToppCell	COVID-19-Epithelial-Ionocytes\|Epithelial / Condition, Lineage and Cell class	RNF152 ENC1 URB2 KIT	2.11e-04	181	72	4	4a8d4f2709c1b25f908867f1b2fae1d2d0abf1d4
ToppCell	COVID-19-kidney-Stressed_PCT\|COVID-19 / Disease (COVID-19 only), tissue and cell type	ZYG11A GDA DPYS RNF152	2.11e-04	181	72	4	6980ea624151da32b7f537f263e40fcb87a02e81
ToppCell	RA-07._Pericyte\|World / Chamber and Cluster_Paper	RNF152 NBEAL1 MAPK10 ARHGEF17	2.15e-04	182	72	4	2075efeae633550fb2eb026d0dfd741c8252482e
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ZYG11A GDA DPYS RNF152	2.20e-04	183	72	4	facd6dbe0851b537d70a899ac7485714ab27d071
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ZYG11A GDA DPYS RNF152	2.20e-04	183	72	4	84b64cf728629c3af9a8d2ed15b93adf562c54b8
ToppCell	facs-Lung-EPCAM-24m-Epithelial-ciliated_columnar_cell_of_tracheobronchial_tree\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DYDC1 CATIP ARMH1 DNAH6	2.24e-04	184	72	4	afb11ab301ef9801333dbb53ccff4bd0d44f1677
ToppCell	facs-Lung-EPCAM-24m-Epithelial-Ciliated_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DYDC1 CATIP ARMH1 DNAH6	2.24e-04	184	72	4	a411c0bcb283534a1c15f22473c46b7d87e01294
ToppCell	Fetal_29-31_weeks-Epithelial-ciliated_cell-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	MROH9 CATIP DNAH6 FBXO15	2.29e-04	185	72	4	3e39a3cb534dfe2301930f3e2f7e8cefb522c158
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ZYG11A GDA DPYS RNF152	2.34e-04	186	72	4	8287146f0ba415ea04475588117d4668ae00f75c
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ZYG11A GDA DPYS RNF152	2.34e-04	186	72	4	5784d255e9ca449d375d81938d0fbbd8a7eb44f6
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ZYG11A GDA DPYS RNF152	2.38e-04	187	72	4	71eb26ebf60cb0848e5bf1cd01edccda621aecd8
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ZYG11A GDA DPYS RNF152	2.38e-04	187	72	4	dcf6475ece5b34d9d58a0d1f51c18acedb19c119
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ZYG11A GDA DPYS RNF152	2.38e-04	187	72	4	f1356273bd3587b6883295edf15cb9cdb706c057
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ZYG11A GDA DPYS RNF152	2.43e-04	188	72	4	f3edcefeef2ce19086032d98b243c02a6d542b38
ToppCell	Control-Epithelial_cells\|Control / group, cell type (main and fine annotations)	NBEAL1 LRRK2 MAPK10 ALPL	2.43e-04	188	72	4	707ebf76cc6fb600b2f07793cf4ea9482c0de79d
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ZYG11A GDA DPYS RNF152	2.43e-04	188	72	4	0792432cd4c564dea1102241ea9884f7ced7658c
ToppCell	COVID-19-lung-Ciliated\|COVID-19 / Disease (COVID-19 only), tissue and cell type	MROH9 DYDC1 DNAH6 FBXO15	2.48e-04	189	72	4	a2da5debd10f27b1280b40141ef0bfef007cc72c
ToppCell	Control-B_intermediate-6\|Control / disease group and sub_cluster of B and Plasma cells(res = 0.5)	DUS2 SACS ENC1 LRRK2	2.48e-04	189	72	4	11cb9a16f1de8f60af2073ed7ea6d4f41c02f299
ToppCell	3'-Parenchyma_lung-Immune_Myeloid_mast-Myeloid_Mast/Baso-mast_cell-Mast_cells-Mast_cells_L.1.4.1.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MAS1L SLC2A14 ARMH1 KIT	2.48e-04	189	72	4	d26af19fd7e0c7eb78a5a3a245ca5229c4e9e847
ToppCell	COVID-19-lung-Ciliated\|lung / Disease (COVID-19 only), tissue and cell type	MROH9 DYDC1 DNAH6 FBXO15	2.48e-04	189	72	4	27329c4661aebabd19fac7fe5dca263fe99d76f3
ToppCell	B_cell_maturation-CD34+_pre-plamsa\|B_cell_maturation / Lineage and Cell class	RNF152 HPS4 SARDH ANKRD50	2.58e-04	191	72	4	4ee160a863d4fb9c4c9449633b9f337db8871992
ToppCell	PBMC-Mild-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_1\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	LRRK2 SLC2A14 ARMH1 PGD	2.58e-04	191	72	4	c9f3bdb5c0a90268cab24a0fe4c3a8290fcedeb8
ToppCell	10x5'-Liver-Myeloid_Mac-Macrophage\|Liver / Manually curated celltypes from each tissue	OTOA GDA DPYS HPS4	2.58e-04	191	72	4	bd7fd445e3d6316d0336c109889e7e6dc394a55e
ToppCell	PBMC-Mild-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_1\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	LRRK2 SLC2A14 ARMH1 PGD	2.64e-04	192	72	4	b86476037ddf8904c1d8a6b3763af7242c031cf3
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro1_(4)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	MROH9 MAPK10 FXYD1 IFIT1	2.69e-04	193	72	4	9f69edc97b868d23998abc98928a2e89a885ef8a
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro1_(4)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	MROH9 MAPK10 FXYD1 IFIT1	2.74e-04	194	72	4	71d3c7448b1734de54187f902f65649f9283bd4c
ToppCell	IPF-Multiplet-Multiplet\|World / Disease state, Lineage and Cell class	MROH9 BMPR1B MAPK10 DNAH6	2.80e-04	195	72	4	21dbdc803c6947024dc2416e9e21c2ef0af9bc31
ToppCell	severe-Lymphocytic-CD4_T_cells_2\|Lymphocytic / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	LRRK2 IFIT1 PGD ALPL	2.91e-04	197	72	4	3b71e523d8a68f131def17233385df371db70db5
ToppCell	Tracheal-10x5prime-Epithelial-Epi_airway_ciliated-Deuterosomal\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	CDK20 MROH9 DYDC1 DNAH6	2.91e-04	197	72	4	6e4a411ef823ce9e16f420e185e21fa19d13af34
ToppCell	Epithelial_cells-Epithelial_cells\|World / Immune cells in Kidney/Urine in Lupus Nephritis	GDA DPYS RNF152 ALPL	2.96e-04	198	72	4	52e9d41a1726bc1140df6baec9f17a534448ac8b
ToppCell	systemic_lupus_erythematosus-flare-Myeloid\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	LRRK2 IFIT1 PGD LYST	2.96e-04	198	72	4	189346c5eb715f3be427bec3b8e067ababb5b475
ToppCell	Severe-B_intermediate-10\|Severe / disease group and sub_cluster of B and Plasma cells(res = 0.5)	VPS13C ENC1 LRRK2 FXYD1	2.96e-04	198	72	4	dfae26c3513a82bb7cb8dadbfcea2a1f420b1bab
ToppCell	severe-Myeloid\|severe / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	LRRK2 IFIT1 PGD ALPL	2.96e-04	198	72	4	d19902a6353445f9875dec59933b7553f5145b8b
ToppCell	LPS_only-Epithelial_airway-airway_epithelial-Ciliated\|LPS_only / Treatment groups by lineage, cell group, cell type	CATIP ARMH1 DNAH6 FBXO15	2.96e-04	198	72	4	6d90b541fde357fbb40f8f7d4e8628a48b679718
ToppCell	Epithelial_cells\|World / Immune cells in Kidney/Urine in Lupus Nephritis	GDA DPYS RNF152 ALPL	2.96e-04	198	72	4	eeec789d226171f30799577cc37c07bdced2e3cb
ToppCell	LPS_IL1RA_TNF-Hematopoietic_Myeloid-Granulocytic_cells-Neutrophils\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	LRRK2 PGD LYST ALPL	3.02e-04	199	72	4	8c2ab13b5fffbab3da37041a7000d6537fc4db09
ToppCell	Bronchial-NucSeq-Epithelial-Epi_airway_ciliated\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DYDC1 CATIP DNAH6 FBXO15	3.02e-04	199	72	4	2498237b9e895ca4826a3378d9d40989968df72b
ToppCell	Bronchial-NucSeq-Epithelial-Epi_airway_ciliated-Ciliated\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DYDC1 CATIP DNAH6 FBXO15	3.02e-04	199	72	4	542ec45c931b40738df1f3777b00c83be33a514a
ToppCell	Severe-B_intermediate-6\|Severe / disease group and sub_cluster of B and Plasma cells(res = 0.5)	DUS2 ENC1 LRRK2 FXYD1	3.02e-04	199	72	4	bf6ebb63ab361d9d1946225894d7be433e9befab
ToppCell	LPS_IL1RA_TNF-Hematopoietic_Myeloid-Granulocytic_cells\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	LRRK2 PGD LYST ALPL	3.08e-04	200	72	4	1592ca96c59eb053d0f0915afb337db9f3a40c91
ToppCell	Parenchymal-10x3prime_v2-Stromal-Pericyte\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	RNF152 NCKIPSD FXYD1 ARHGEF17	3.08e-04	200	72	4	d70bad979299615fcba707ba21296020918705e6
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_airway_ciliated-Ciliated\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	MROH9 DYDC1 CATIP DNAH6	3.08e-04	200	72	4	926a7ea94b5908aebf103893ea83ce9d25285b65
ToppCell	Tracheal-NucSeq-Epithelial-Epi_airway_ciliated-Ciliated\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DYDC1 CATIP DNAH6 FBXO15	3.08e-04	200	72	4	af6a551f83808c1c839df7ba7b1702ca28ea6e1b
ToppCell	Parenchymal-10x3prime_v2-Stromal-Pericyte-Muscle_pericyte_pulmonary\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	RNF152 NCKIPSD FXYD1 ARHGEF17	3.08e-04	200	72	4	38c21ec379005f688df33aea65237a063c476c2e
ToppCell	Tracheal-NucSeq-Epithelial-Epi_airway_ciliated\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DYDC1 CATIP DNAH6 FBXO15	3.08e-04	200	72	4	73ac1cf40ddd764be1100cbfaaa29563665457d8
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_airway_ciliated\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	MROH9 DYDC1 CATIP DNAH6	3.08e-04	200	72	4	06ce6e03498ba38ef6a06eaf2731e3b2eeda59eb
Drug	benzothiazol-2-ylacetonitrile	MAPK8 MAPK9 MAPK10	2.91e-08	3	71	3	CID000342465
Drug	AC1MJ5N7	MAPK8 MAPK9 MAPK10	2.89e-07	5	71	3	CID003086135
Drug	AC1L3ZTY	MAPK8 MAPK9 MAPK10	1.01e-06	7	71	3	CID000098120
Drug	fludelone	MAPK8 MAPK9 MAPK10	1.01e-06	7	71	3	CID006918712
Drug	methyldiazonium ion	MAPK8 MAPK9 MAPK10	1.61e-06	8	71	3	CID000115287
Drug	Suloctidil [54063-56-8]; Up 200; 11.8uM; PC3; HT_HG-U133A	BMPR1B ABCA2 MAU2 ARHGEF17 KIT IFIT1 KLHL22	1.86e-06	186	71	7	6675_UP
Drug	S 52	MAPK8 MAPK9 MAPK10	2.41e-06	9	71	3	CID000023681
Drug	AC1L6EKE	MAPK8 MAPK9 MAPK10	2.41e-06	9	71	3	CID000265720
Drug	D-JNKI-1	MAPK8 MAPK9 MAPK10	3.43e-06	10	71	3	ctd:C478085
Drug	irisolidone	MAPK8 MAPK9 MAPK10	3.43e-06	10	71	3	CID005281781
Drug	AC1NURR2	MAPK8 MAPK9 MAPK10	4.71e-06	11	71	3	CID005490351
Drug	9-CP-Ade	MAPK8 MAPK9 MAPK10	4.71e-06	11	71	3	CID000012852
Drug	anthrapyrazole	MAPK8 MAPK9 MAPK10	6.27e-06	12	71	3	CID000119330
Drug	Kinome_3024	MAPK9 MAPK10	9.59e-06	2	71	2	CID011539329
Drug	Kinome_3019	MAPK9 MAPK10	9.59e-06	2	71	2	CID011658882
Drug	Kinome_3027	MAPK9 MAPK10	9.59e-06	2	71	2	CID011640926
Drug	Kinome_3028	MAPK9 MAPK10	9.59e-06	2	71	2	CID011590363
Drug	Kinome_3025	MAPK9 MAPK10	9.59e-06	2	71	2	CID011715520
Drug	farnesylamine	MAPK8 MAPK9 MAPK10	1.03e-05	14	71	3	CID006449783
Drug	E-4IB	MAPK8 MAPK9 MAPK10	1.29e-05	15	71	3	CID000123372
Drug	Ambotz208527-57-5	MAPK8 MAPK9 MAPK10	1.92e-05	17	71	3	CID010258704
Drug	3-nonenal	MAPK8 MAPK9 MAPK10	2.29e-05	18	71	3	CID005283336
Drug	NSC363979	MAPK8 MAPK9 MAPK10	2.29e-05	18	71	3	CID000183413
Drug	Thr-Gly	MAPK8 MAPK9 MAPK10	2.72e-05	19	71	3	CID006427013
Drug	CGC 11093	MAPK8 MAPK9	2.87e-05	3	71	2	ctd:C515676
Drug	5,5-dimethylhydantoin	DPYS FOLH1	2.87e-05	3	71	2	CID000006491
Drug	Calebin-A	MAPK9 MAPK10	2.87e-05	3	71	2	CID000637429
Drug	N-glyceryl-2-hexyl-3-keto-capramide	MAPK9 MAPK10	2.87e-05	3	71	2	CID011645877
Drug	N,N-dimethyl-5H-purin-6-amine	MAPK8 MAPK9 MAPK10	3.19e-05	20	71	3	CID000436439
Drug	CGP7040	MAPK9 MAPK10 LYST	3.19e-05	20	71	3	CID006436259
Drug	estradiol, USP; Down 200; 0.01uM; MCF7; HT_HG-U133A	DUS2 DOHH VPS33A ENC1 IFIT1 KLHL22	3.49e-05	197	71	6	5238_DN
Drug	Cefuroxime sodium salt [56238-63-2]; Down 200; 9uM; HL60; HT_HG-U133A	CDK20 DOHH VPS33A MAPK8 IFIT1 KLHL22	3.49e-05	197	71	6	2526_DN
Drug	Kanamycin A sulfate [25389-94-0]; Down 200; 6.8uM; MCF7; HT_HG-U133A	CDK20 ABCA2 HPS4 CABIN1 LYST KLHL22	3.69e-05	199	71	6	3224_DN
Drug	AC1L4O4Q	FOLH1 ELP1 LYST	3.71e-05	21	71	3	CID000189139
Drug	fluphenazine dihydrochloride; Down 200; 10uM; MCF7; HT_HG-U133A	YIPF2 ABCA2 VPS33A URB2 LYST KLHL22	3.80e-05	200	71	6	6996_DN
Drug	Aroclor 1260	HADHA MAPK9 MAPK10	4.29e-05	22	71	3	CID000038018
Drug	octadec-9-en-1-amine	MAPK8 MAPK9 MAPK10	5.61e-05	24	71	3	CID000008219
Drug	GS-Hna	MAPK8 MAPK9 MAPK10	5.61e-05	24	71	3	CID000444455
Drug	JNK inhibitor VIII	MAPK9 MAPK10	5.73e-05	4	71	2	CID011624601
Drug	O(2)-(2,4-dinitrophenyl) 1-(4-(N,N-diethylcarboxamido)piperazin-1-yl)diazen-1-ium 1,2-diolate	MAPK8 MAPK9	5.73e-05	4	71	2	ctd:C495194
Drug	N1-Methyl-1,9-pyrazoloanthrone	MAPK9 MAPK10	5.73e-05	4	71	2	CID011665831
Drug	Ns102	MAPK8 MAPK9 MAPK10	6.36e-05	25	71	3	CID005311098
Drug	2,4,3',5'-tetramethoxystilbene	MAPK8 MAPK9 MAPK10	6.36e-05	25	71	3	ctd:C440850
Drug	dopamine quinone	CACNA1S LRRK2 MAPK9 MAPK10	6.44e-05	69	71	4	CID000162602
Drug	AC1NDZBN	MAPK8 MAPK9 MAPK10	8.06e-05	27	71	3	CID004634037
Drug	K00085	MAPK8 MAPK9 MAPK10	8.06e-05	27	71	3	CID009549283
Drug	AN-22	MAPK8 MAPK9 MAPK10	8.06e-05	27	71	3	CID000055769
Drug	AC1L1BHQ	NCKIPSD HADHA MAPK8 MAPK9 MAPK10 PGD	8.24e-05	230	71	6	CID000001444
Drug	SB225002	MAPK8 MAPK9 MAPK10	9.00e-05	28	71	3	CID003854666
Drug	AC1L9CMN	MAPK8 MAPK9	9.53e-05	5	71	2	CID000442339
Drug	betamethasone butyrate propionate	MAPK9 MAPK10	9.53e-05	5	71	2	CID000071470
Drug	ovatodiolide	MAPK8 MAPK9	9.53e-05	5	71	2	ctd:C432447
Drug	SB220025	MAPK8 MAPK9 MAPK10	1.00e-04	29	71	3	CID000005164
Drug	AC1NQZM2	MAPK8 MAPK9 MAPK10	1.00e-04	29	71	3	CID005282177
Drug	(2S)-2-amino-5-[[(2R)-3-[[(2R)-2-[[(4S)-4-amino-4-carboxybutanoyl]amino]-3-[[[(2R)-2-[[(4S)-4-amino-4-carboxybutanoyl]amino]-3-[[(2R)-2-[[(4S)-4-amino-4-carboxybutanoyl]amino]-3-(carboxymethylamino)-3-oxopropyl]disulfanyl]propanoyl]-(carboxymethyl)amino]selanyl-(carboxymethyl)amino]-3-oxopropyl]disulfanyl]-1-(carboxymethylamino)-1-oxopropan-2-yl]amino]-5-oxopentanoic acid	MAPK8 MAPK9 MAPK10	1.23e-04	31	71	3	CID009543188
Drug	K00039	MAPK8 MAPK9 MAPK10	1.35e-04	32	71	3	CID009549277
Drug	alpha-APP modulator	MAPK9 MAPK10	1.43e-04	6	71	2	CID009935767
Drug	indole-5-carboxamide	MAPK8 MAPK9	1.43e-04	6	71	2	ctd:C514526
Drug	Vinyl Compounds	MAPK8 MAPK9	1.43e-04	6	71	2	ctd:D014753
Drug	pramipexole	MAPK8 MAPK9	1.43e-04	6	71	2	ctd:C061333
Drug	Eosine I Bluish	MAPK8 MAPK9	1.43e-04	6	71	2	ctd:D010697
Drug	lapatinib	NCKIPSD MAPK8 MAPK9 MAPK10	1.52e-04	86	71	4	CID000208908
Drug	tofacitinib	MAPK8 MAPK9 IFIT1 KLHL31	1.52e-04	86	71	4	ctd:C479163
Drug	quinolone	HADHA MAPK9 FXYD1	1.62e-04	34	71	3	CID000006038
Drug	WR-1065	MAPK9 MAPK10 ALPL	1.62e-04	34	71	3	CID000104807
Drug	AG213	DAGLB MAPK9 MAPK10 ZP3	1.74e-04	89	71	4	CID005328803
Drug	Dicumarol	MAPK8 MAPK9 MAPK10	1.77e-04	35	71	3	ctd:D001728
Drug	pyridinyl imidazole	MAPK8 MAPK9 MAPK10	1.93e-04	36	71	3	CID000005171
Drug	LL Z1640-2	MAPK8 MAPK9	1.99e-04	7	71	2	ctd:C118715
Drug	vioxanthin	MAPK9 MAPK10	1.99e-04	7	71	2	CID000119072
Drug	2-(4-((dimethylamino)methyl)benzylidene)-5,6-dimethoxy-2,3-dihydroinden-1-one	MAPK8 MAPK9	1.99e-04	7	71	2	ctd:C543150
Drug	satratoxin H	MAPK9 MAPK10	1.99e-04	7	71	2	CID000434380
Drug	iomeprol	MAPK8 MAPK9	1.99e-04	7	71	2	ctd:C057937
Drug	poly(N-vinylpyrrolidine)	MAPK8 MAPK9	1.99e-04	7	71	2	ctd:C505150
Drug	AA100	MAPK9 MAPK10	1.99e-04	7	71	2	CID010490261
Drug	SB366791	MAPK9 MAPK10	1.99e-04	7	71	2	CID000667594
Drug	Laevuflex	GDA SLC2A14 MAPK8 MAPK9 MAPK10 PGD	2.06e-04	272	71	6	CID000003426
Drug	pifithrin	MAPK8 MAPK9 MAPK10 KIT	2.23e-04	95	71	4	ctd:C121565
Drug	hydroxytyrosol	MAPK8 MAPK9 MAPK10	2.45e-04	39	71	3	CID000082755
Drug	N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide	MAPK8 MAPK9 MAPK10	2.45e-04	39	71	3	ctd:C078131
Drug	diethylpyrocarbonate	HADHA MAPK8 MAPK9 MAPK10 ALPL	2.62e-04	182	71	5	CID000003051
Drug	procymidone	MAPK8 MAPK9 MAPK10	2.64e-04	40	71	3	CID000036242
Drug	p-XSC	MAPK8 MAPK9 MAPK10	2.64e-04	40	71	3	CID000005708
Drug	SDZ 62-434	MAPK9 MAPK10	2.65e-04	8	71	2	CID000130786
Drug	eupafolin	MAPK8 MAPK9	2.65e-04	8	71	2	ctd:C503624
Drug	Silicates	MAPK8 MAPK9	2.65e-04	8	71	2	ctd:D017640
Drug	I50 - 9	MAPK9 MAPK10	2.65e-04	8	71	2	CID000083651
Drug	caffeoylquinic acid	MAPK8 MAPK9	2.65e-04	8	71	2	ctd:C472707
Drug	tyrphostin A9	MAPK8 MAPK9	2.65e-04	8	71	2	ctd:C406122
Drug	desisobutyrylciclesonide	MAPK8 MAPK9	2.65e-04	8	71	2	ctd:C494355
Drug	piribedil	MAPK8 MAPK9 MAPK10	3.06e-04	42	71	3	CID000004850
Drug	AC1Q6X9N	MAPK8 MAPK9 MAPK10	3.06e-04	42	71	3	CID000072205
Drug	NF T	DPYS ABCA2 HPS4 MAPK8 MAPK9	3.20e-04	190	71	5	CID006436102
Drug	15d-PGJ2; Down 200; 10uM; HL60; HT_HG-U133A	DUS2 HPS4 URB2 CABIN1 LYST	3.20e-04	190	71	5	1172_DN
Drug	AC1LDMDX	MAPK8 MAPK9 MAPK10	3.28e-04	43	71	3	CID000621355
Drug	5-styrylbenzene-1,3-diol	FOLH1 LYST	3.40e-04	9	71	2	CID000100754
Drug	SC68376	MAPK9 MAPK10	3.40e-04	9	71	2	CID000005174
Drug	FK960	MAPK9 MAPK10	3.40e-04	9	71	2	CID000181428
Drug	2''-galloylhyperin	MAPK8 MAPK9	3.40e-04	9	71	2	ctd:C087939
Drug	pholedrine sulfuric acid ester	FOLH1 LYST	3.40e-04	9	71	2	CID003082701
Disease	Alzheimer disease, polygenic risk score	FSIP2 OR4C3 DNAJA2 LRRK2 NCKIPSD ZSWIM2 HADHA ALPL	6.65e-05	586	69	8	EFO_0030082, MONDO_0004975
Disease	Alzheimer's disease (is_marker_for)	MRE11 HADHA MAPK8 MAPK9 MAPK10	3.44e-04	257	69	5	DOID:10652 (is_marker_for)
Disease	Trigeminal Neuralgia	MAPK8 MAPK9	3.50e-04	12	69	2	C0040997
Disease	Secondary Trigeminal Neuralgia	MAPK8 MAPK9	3.50e-04	12	69	2	C0393787
Disease	Trigeminal Neuralgia, Idiopathic	MAPK8 MAPK9	3.50e-04	12	69	2	C0393786
Disease	Parkinson's disease (implicated_via_orthology)	VPS13C MAPK8 MAPK9 MAPK10	5.10e-04	157	69	4	DOID:14330 (implicated_via_orthology)
Disease	platelet storage pool deficiency (implicated_via_orthology)	HPS4 LYST	5.55e-04	15	69	2	DOID:2223 (implicated_via_orthology)
Disease	pancreatic adenocarcinoma (is_implicated_in)	MAPK9 MAPK10	5.55e-04	15	69	2	DOID:4074 (is_implicated_in)
Disease	tooth agenesis	CACNA1S NOL11	1.21e-03	22	69	2	EFO_0005410
Disease	lobe attachment	MROH9 CACNA1S SACS ANKRD50	1.42e-03	207	69	4	EFO_0007667
Disease	Parkinsonian Disorders	LRRK2 LYST	2.25e-03	30	69	2	C0242422

Protein segments in the cluster

Peptide	Gene	Start	Entry
HYFLVLLSMAVTKLG	URB2	916	Q14146
SYLQMLLKGVAFCHA	CDK20	106	Q8IZL9
CVLKVLGTMHLEVQY	ARMH1	226	Q6PIY5
QLICEAYHLMKDVLG	PGD	196	P52209
MLNQLHIKSSGCFLY	ANKRD50	291	Q9ULJ7
MLKLAYSSVSGLCHL	BMPR1B	301	O00238
SALLKHELAYCLGQM	DOHH	51	Q9BU89
LQLLTHILNYVMCKG	NBEAL1	1441	Q6ZS30
YVAICKPLHCLSIMN	OR6C1	121	Q96RD1
YILMAKGLHCSTVKD	INTS8	571	Q75QN2
IHTGFMLRLFLCKTN	OR8G2P	171	Q6IF36
LMQLIQTHVLSYSLC	NOL11	456	Q9H8H0
MKLQHAASVTCILYL	ARHGEF17	1766	Q96PE2
QVLLYQMIKCSHLRG	OTOA	361	Q7RTW8
LLYQMLCGIKHLHSA	MAPK9	131	P45984
HYTVIMSKRLCLALI	OR8H2	131	Q8N162
AAVYLQIHTLVKMCS	KLHL31	146	Q9H511
MESIYLQKHLGACLT	DYDC1	1	Q8WWB3
YQMLCGIKHLHSAGI	MAPK10	171	P53779
ALMSELKVLSYLGNH	KIT	636	P10721
NCPLYIVHVMSKSAA	DPYS	241	Q14117
CTPLMYSLVHNLTKE	FOLH1	466	Q04609
MNLYTHCVKGLVLSL	HPS4	541	Q9NQG7
LLCKILYAFSHNMLV	FSIP2	4956	Q5CZC0
LLYQMLCGIKHLHSA	MAPK8	131	P45983
IMKLACSSIIVNHIY	OR51G1	186	Q8NGK1
LLYTVLISHTLCLKM	OR5A2	131	Q8NGI9
LISHTLCLKMVVGAY	OR5A2	136	Q8NGI9
ITLHMLNGYLLASKA	INTS2	876	Q9H0H0
HILVFCVGLLTMAKA	FXYD1	6	O00168
HKMSYSGRVKTLCLQ	LRRK2	2406	Q5S007
VMESINPHKYCLSIL	ELP1	826	O95163
IVKQASLGMCHLLYI	MROH9	186	Q5TGP6
TLMTVSLLLKNHYNG	SLC2A14	371	Q8TDB8
KLSGLFHAILSLVMC	MAS1L	226	P35410
YTAKMIHQLCALLVT	OR1F2P	131	Q96R84
ALSQGCKDIAYQLMH	ALPL	196	P05186
DLHMTYKIGLVEALC	DNAJA2	266	O60884
LLKINELCYHLSFMG	DNAH6	316	Q9C0G6
VLIHGVSYNAMCQIL	KLHL22	91	Q53GT1
KCLGESLLAMYNHLT	CABIN1	271	Q9Y6J0
ALIMLNTICLGMQHY	CACNA1S	1126	Q13698
ILTLYLMHRGKLDCA	DAGLB	36	Q8NCG7
KYNLSHLTISTMIGC	FBXO15	271	Q8NCQ5
ALTAILKYGQVLMHS	ABCA2	766	Q9BZC7
QEKLGMLTYCLFVHA	CATIP	76	Q7Z7H3
CIHIISLGSKALMIQ	LYST	1536	Q99698
LLHHQIGLCYKAQMI	IFIT1	286	P09914
SKALMGLYHGQVLCK	HADHA	336	P40939
LTNKTVMAHGCYLSA	GDA	271	Q9Y2T3
GMLLLSDAHQCTKLY	ENC1	151	O14682
LTTQAYCKMVLHGAK	EMC8	6	O43402
MILNSLSLCYHNKLI	DUS2	1	Q9NX74
LSLCYHNKLILAPMV	DUS2	6	Q9NX74
QMLVDLSQCYLGKDH	SACS	3941	Q9NZJ4
LHTLLGLYCVSVNCM	MAU2	381	Q9Y6X3
LKLHCLQKLYMNSVS	PRAMEF26	171	H0Y7S4
HGLITHYKIGALCMN	KIFAP3	211	Q92845
YVAICKPLHNTTIMT	OR4C3	121	Q8NH37
YQLLMCHKTGEALQA	MROH5	661	Q6ZUA9
FLLGIVLHNMSCISK	RNF152	181	Q8N8N0
TLHTCLELLRKYCMG	MRE11	71	P49959
PLHYTSIMNRKLCTL	OR6C3	126	Q9NZP0
QDHQKLCYSALILAM	NCKIPSD	496	Q9NZQ3
SLGCQTLYHLAKLGM	SARDH	76	Q9UL12
ILCKHLLAVYLSQVM	ZSWIM7	101	Q19AV6
LMCHFKLVAIVGYLI	TMPRSS7	271	Q7RTY8
GCIQIVYLHKFLMSL	VPS13C	1186	Q709C8
SIHIKCMKILANYQS	ZSWIM2	171	Q8NEG5
SLYHAAKGLMTLQAL	VPS33A	171	Q96AX1
VVLLHALLAMGCKLY	YIPF2	266	Q9BWQ6
HYLKCLAMTKSQILA	ZYG11A	236	Q6WRX3
NMIYITCHLKVTLAE	ZP3	276	P21754
CMVGLHFLTNLILEK	LRRCC1	156	Q9C099