Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionnon-membrane spanning protein tyrosine kinase activity

TYK2 CLK1

7.76e-0446182GO:0004715
GeneOntologyMolecularFunctioncopper ion binding

F5 CP

2.21e-0378182GO:0005507
DomainCu-oxidase_3

F5 CP

7.79e-065172IPR011707
DomainCu_oxidase_CS

F5 CP

7.79e-065172IPR033138
DomainMULTICOPPER_OXIDASE1

F5 CP

7.79e-065172PS00079
DomainCu-oxidase_3

F5 CP

7.79e-065172PF07732
DomainCu_oxidase_Cu_BS

F5 CP

1.17e-056172IPR002355
Domain-

F5 CP

7.05e-05141722.60.40.420
DomainCupredoxin

F5 CP

1.78e-0422172IPR008972
DomainProtein_kinase_ATP_BS

TYK2 CLK1 LIMK1

4.56e-03379173IPR017441
DomainPkinase_Tyr

TYK2 LIMK1

6.02e-03129172PF07714
DomainSer-Thr/Tyr_kinase_cat_dom

TYK2 LIMK1

6.85e-03138172IPR001245
DomainPROTEIN_KINASE_ATP

TYK2 CLK1 LIMK1

7.76e-03459173PS00107
DomainProt_kinase_dom

TYK2 CLK1 LIMK1

9.23e-03489173IPR000719
DomainPROTEIN_KINASE_DOM

TYK2 CLK1 LIMK1

9.44e-03493173PS50011
DomainKinase-like_dom

TYK2 CLK1 LIMK1

1.22e-02542173IPR011009
PathwayREACTOME_INACTIVATION_OF_CSF3_G_CSF_SIGNALING

TYK2 CUL5

2.33e-0425132M41829
PathwayREACTOME_SIGNALING_BY_CSF3_G_CSF

TYK2 CUL5

3.37e-0430132M41825
PathwayREACTOME_EVASION_BY_RSV_OF_HOST_INTERFERON_RESPONSES

TYK2 CUL5

4.59e-0435132M48246
Pubmed

Suppressor of Cytokine Signaling (SOCS) 5 utilises distinct domains for regulation of JAK1 and interaction with the adaptor protein Shc-1.

TYK2 CUL5

1.97e-051318223990909
Pubmed

14-3-3-affinity purification of over 200 human phosphoproteins reveals new links to regulation of cellular metabolism, proliferation and trafficking.

CUL5 CARM1 DNPEP

1.16e-0418618314744259
Pubmed

Synergistic drug combinations for cancer identified in a CRISPR screen for pairwise genetic interactions.

TYK2 CUL5 CARM1

3.69e-0427618328319085
Pubmed

MBD5 and MBD6 stabilize the BAP1 complex and promote BAP1-dependent cancer.

CUL5 CARM1 DNPEP

4.14e-0428718336180891
InteractionASXL3 interactions

CUL5 CARM1 CLK1 DNPEP

9.49e-06165174int:ASXL3
Cytoband1q44

OR2T8 OR2T33

9.47e-041101921q44
CytobandEnsembl 112 genes in cytogenetic band chr1q44

OR2T8 OR2T33

1.28e-03128192chr1q44
Cytoband19p13.2

TYK2 CARM1

4.01e-0322919219p13.2
GeneFamilyOlfactory receptors, family 2

OR2T8 OR2T33

2.45e-03113122149
DiseasePsoriasis

TYK2 CARM1 CP

5.46e-0657183C0033860
DiseasePustulosis of Palms and Soles

TYK2 CARM1 CP

5.46e-0657183C0030246
Diseaseinflammatory bowel disease

TYK2 F5 DNPEP SIAH3

1.37e-04449184EFO_0003767
DiseaseDiabetes Mellitus

CYBB CP

1.72e-0432182C0011849
Diseasesystemic scleroderma, rheumatoid arthritis, myositis, systemic lupus erythematosus

TYK2 LIMK1

2.44e-0438182EFO_0000685, EFO_0000717, EFO_0000783, MONDO_0007915
DiseaseDiabetes Mellitus, Sudden-Onset

TYK2 CP

3.27e-0444182C4554117
DiseaseDiabetes Mellitus, Ketosis-Prone

TYK2 CP

3.27e-0444182C3837958
DiseaseDiabetes, Autoimmune

TYK2 CP

3.27e-0444182C0205734
DiseaseBrittle diabetes

TYK2 CP

3.27e-0444182C0342302
DiseaseDiabetes Mellitus, Insulin-Dependent

TYK2 CP

3.43e-0445182C0011854
DiseaseLiver Cirrhosis

F5 CP

1.78e-03103182C0023890
DiseaseFibrosis, Liver

F5 CP

1.85e-03105182C0239946
Diseaserheumatoid arthritis

TYK2 CUL5 DNPEP

2.61e-03462183EFO_0000685

Protein segments in the cluster

PeptideGeneStartEntry
LHWHHLMSNGIITFK

CUL5

571

Q93034
HHSVLMSLLCAHLGL

DNPEP

226

Q9ULA0
LHELMHVLGFWHEHT

ASTL

181

Q6HA08
QMLEWFEHHGHICIV

CLK1

226

P49759
WLLHCHVTDHIHAGM

CP

1036

P00450
FHMLHSGLVHGLAFW

CARM1

376

Q86X55
SLMILLIHWDHRLHT

OR2T8

41

A6NH00
SLMILLIHWDHRLHT

OR2T33

41

Q8NG76
EHLYHWIHICSALMK

EFCAB5

1456

A4FU69
WMIALHSAIHTIAHL

CYBB

106

P04839
WLHMHRLVLILEHDT

SZT2

576

Q5T011
LHWIFQISHMLLHFF

TMEM217B

121

A0A494BZU4
TVCAHDHISWHLLGM

F5

246

P12259
WIIMHSCLGHHFLLV

SIAH3

156

Q8IW03
QEHGHRMLLIWLHGV

ANKDD1A

456

Q495B1
ITHHVLSGKWLMHLA

C11orf68

161

Q9H3H3
LGHLLCFHIYLMWHK

ZDHHC1

261

Q8WTX9
MAFLHLCHLALRHGI

TYK2

186

P29597
EHWLETLRMHLAGHL

LIMK1

601

P53667