Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	GATA6 SP8 POU3F1 MAFB SOX21 PRDM4 GLI3 MEIS1 MEIS2 SKOR2 ESRRB	1.74e-05	1244	39	11	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	GATA6 SP8 POU3F1 MAFB SOX21 PRDM4 GLI3 MEIS1 MEIS2 SKOR2 ESRRB	2.13e-05	1271	39	11	GO:0000987
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	GATA6 SP8 POU3F1 MAFB SOX21 PRDM4 GLI3 MEIS1 MEIS2 SKOR2 ESRRB	5.62e-05	1412	39	11	GO:0000981
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	GATA6 SP8 POU3F1 MAFB SOX21 PRDM4 GLI3 MEIS1 MEIS2 SKOR2 ESRRB	7.57e-05	1459	39	11	GO:0000977
GeneOntologyMolecularFunction	DNA-binding transcription activator activity, RNA polymerase II-specific	MAFB SOX21 PRDM4 MEIS1 MEIS2 ESRRB	7.03e-04	560	39	6	GO:0001228
GeneOntologyMolecularFunction	DNA-binding transcription activator activity	MAFB SOX21 PRDM4 MEIS1 MEIS2 ESRRB	7.43e-04	566	39	6	GO:0001216
GeneOntologyBiologicalProcess	skin development	GATA6 FLG POU3F1 MAFB HRNR SOX21 FLG2 AHDC1	4.00e-07	373	39	8	GO:0043588
GeneOntologyBiologicalProcess	skin epidermis development	GATA6 FLG HRNR SOX21 FLG2	1.47e-05	166	39	5	GO:0098773
GeneOntologyBiologicalProcess	positive regulation of cardiac muscle myoblast proliferation	GATA6 MEIS2	2.09e-05	4	39	2	GO:0110024
GeneOntologyBiologicalProcess	epidermis development	GATA6 FLG POU3F1 MAFB HRNR SOX21 FLG2	2.20e-05	461	39	7	GO:0008544
GeneOntologyBiologicalProcess	pattern specification process	SP8 MAFB ANKS6 GLI3 MEIS1 MEIS2 RNF111	5.11e-05	526	39	7	GO:0007389
GeneOntologyBiologicalProcess	establishment of skin barrier	FLG HRNR FLG2	6.34e-05	41	39	3	GO:0061436
GeneOntologyBiologicalProcess	regulation of cardiac muscle myoblast proliferation	GATA6 MEIS2	7.27e-05	7	39	2	GO:0110022
GeneOntologyBiologicalProcess	cardiac muscle myoblast proliferation	GATA6 MEIS2	7.27e-05	7	39	2	GO:0110021
GeneOntologyBiologicalProcess	negative regulation of transcription by RNA polymerase II	GATA6 POU3F1 MAFB ZNF469 SOX21 TRIM37 GLI3 MEIS2 SKOR2	1.20e-04	1053	39	9	GO:0000122
GeneOntologyBiologicalProcess	epidermal cell differentiation	GATA6 FLG POU3F1 MAFB HRNR	1.87e-04	284	39	5	GO:0009913
GeneOntologyBiologicalProcess	negative regulation of DNA-templated transcription	GATA6 POU3F1 MAFB ZNF469 SOX21 TRIM37 GLI3 MEIS2 SKOR2 ESRRB	2.06e-04	1399	39	10	GO:0045892
GeneOntologyBiologicalProcess	negative regulation of RNA biosynthetic process	GATA6 POU3F1 MAFB ZNF469 SOX21 TRIM37 GLI3 MEIS2 SKOR2 ESRRB	2.24e-04	1413	39	10	GO:1902679
GeneOntologyBiologicalProcess	embryo development	GATA6 SP8 MAFB ANKS6 AHDC1 GLI3 MEIS1 KIAA1217 MEIS2 ESRRB	2.57e-04	1437	39	10	GO:0009790
GeneOntologyBiologicalProcess	keratinocyte differentiation	FLG POU3F1 MAFB HRNR	4.37e-04	189	39	4	GO:0030216
GeneOntologyCellularComponent	keratohyalin granule	FLG HRNR FLG2	5.99e-08	5	39	3	GO:0036457
GeneOntologyCellularComponent	cornified envelope	FLG HRNR FLG2	2.89e-04	69	39	3	GO:0001533
GeneOntologyCellularComponent	chromatin	GATA6 SP8 POU3F1 MAFB SOX21 SLF2 SLX4 MEIS1 MEIS2 ESRRB	2.92e-04	1480	39	10	GO:0000785
GeneOntologyCellularComponent	transcription regulator complex	GATA6 POU3F1 MAFB GLI3 MEIS1 SKOR2	7.67e-04	596	39	6	GO:0005667
Domain	Filaggrin	FLG FLG2	4.47e-06	2	40	2	IPR003303
Domain	S100_CABP	FLG HRNR FLG2	2.57e-05	27	40	3	PS00303
Domain	S_100	FLG HRNR FLG2	2.57e-05	27	40	3	PF01023
Domain	S100_Ca-bd_sub	FLG HRNR FLG2	2.87e-05	28	40	3	IPR013787
Domain	S100/CaBP-9k_CS	FLG HRNR FLG2	2.87e-05	28	40	3	IPR001751
Domain	S_100	FLG HRNR FLG2	2.87e-05	28	40	3	SM01394
Domain	Meis_PKNOX_N	MEIS1 MEIS2	4.45e-05	5	40	2	PF16493
Domain	PKNOX/Meis_N	MEIS1 MEIS2	4.45e-05	5	40	2	IPR032453
Domain	-	FLG PLCB3 HRNR FLG2 DTNB	2.26e-04	261	40	5	1.10.238.10
Domain	EF-hand-dom_pair	FLG PLCB3 HRNR FLG2 DTNB	3.51e-04	287	40	5	IPR011992
Domain	Homeobox_KN	MEIS1 MEIS2	5.96e-04	17	40	2	PF05920
Domain	Homeobox_KN_domain	MEIS1 MEIS2	5.96e-04	17	40	2	IPR008422
Domain	C2	PLCB3 HECW1 PCLO	2.76e-03	131	40	3	PF00168
Domain	C2	PLCB3 HECW1 PCLO	3.13e-03	137	40	3	SM00239
Domain	C2	PLCB3 HECW1 PCLO	3.46e-03	142	40	3	PS50004
Domain	-	PLCB3 HECW1 PCLO	3.89e-03	148	40	3	2.60.40.150
Domain	C2_dom	PLCB3 HECW1 PCLO	5.18e-03	164	40	3	IPR000008
Domain	EF_Hand_1_Ca_BS	FLG HRNR FLG2	6.19e-03	175	40	3	IPR018247
Domain	-	GATA6 ESRRB	6.63e-03	57	40	2	3.30.50.10
Domain	Znf_NHR/GATA	GATA6 ESRRB	6.85e-03	58	40	2	IPR013088
Domain	SAM_1	ANKS6 PPFIA1	9.32e-03	68	40	2	PF00536
Domain	EF_HAND_1	FLG HRNR FLG2	9.43e-03	204	40	3	PS00018
Domain	EF_HAND_2	FLG HRNR FLG2	1.32e-02	231	40	3	PS50222
Domain	EF_hand_dom	FLG HRNR FLG2	1.33e-02	232	40	3	IPR002048
Domain	Homeobox	POU3F1 MEIS1 MEIS2	1.36e-02	234	40	3	PF00046
Domain	HOMEOBOX_1	POU3F1 MEIS1 MEIS2	1.40e-02	236	40	3	PS00027
Domain	HOX	POU3F1 MEIS1 MEIS2	1.41e-02	237	40	3	SM00389
Domain	Homeobox_dom	POU3F1 MEIS1 MEIS2	1.44e-02	239	40	3	IPR001356
Domain	HOMEOBOX_2	POU3F1 MEIS1 MEIS2	1.44e-02	239	40	3	PS50071
Pubmed	Defects of filaggrin-like proteins in both lesional and nonlesional atopic skin.	FLG HRNR FLG2	1.64e-09	3	42	3	23403047
Pubmed	A census of human transcription factors: function, expression and evolution.	GATA6 POU3F1 MAFB SOX21 PRDM4 GLI3 MEIS1 MEIS2 SKOR2 ESRRB	9.66e-08	908	42	10	19274049
Pubmed	The AERO system: a 3D-like approach for recording gene expression patterns in the whole mouse embryo.	GATA6 SP8 POU3F1 GLI3 MEIS1 MEIS2	1.13e-07	191	42	6	24146773
Pubmed	Efficient conditional and promoter-specific in vivo expression of cDNAs of choice by taking advantage of recombinase-mediated cassette exchange using FlEx gene traps.	NUP42 AHDC1 KIAA1217	1.37e-07	9	42	3	20139417
Pubmed	A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.	GATA6 POU3F1 SOX21 PRDM4 GLI3 MEIS1 MEIS2 ESRRB RNF111	1.41e-07	709	42	9	22988430
Pubmed	Impact of cytosine methylation on DNA binding specificities of human transcription factors.	GATA6 SP8 POU3F1 PRDM4 GLI3 MEIS2 SKOR2 ESRRB	2.52e-07	544	42	8	28473536
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	GATA6 POU3F1 NUP42 SOX21 PRDM4 GLI3 MEIS1 MEIS2 ESRRB	4.23e-07	808	42	9	20412781
Pubmed	Dlx1&2 and Mash1 transcription factors control MGE and CGE patterning and differentiation through parallel and overlapping pathways.	SP8 POU3F1 MAFB MEIS1 MEIS2	5.14e-07	130	42	5	19386638
Pubmed	Development of the Proximal-Anterior Skeletal Elements in the Mouse Hindlimb Is Regulated by a Transcriptional and Signaling Network Controlled by Sall4.	GLI3 MEIS1 MEIS2	5.91e-07	14	42	3	32156750
Pubmed	Dlx1&2 and Mash1 transcription factors control striatal patterning and differentiation through parallel and overlapping pathways.	SP8 POU3F1 MAFB MEIS1 MEIS2	5.98e-07	134	42	5	19030180
Pubmed	Pitx1 and Pitx2 are required for development of hindlimb buds.	GLI3 MEIS1 MEIS2	1.32e-06	18	42	3	12441290
Pubmed	Hox Proteins Coordinate Motor Neuron Differentiation and Connectivity Programs through Ret/Gfrα Genes.	POU3F1 MEIS1 MEIS2	1.32e-06	18	42	3	26904955
Pubmed	Myeloid ecotropic viral integration site 1 (MEIS) 1 involvement in embryonic implantation.	MEIS1 MEIS2	1.42e-06	2	42	2	18408019
Pubmed	Atopic Dermatitis Susceptibility Variants in Filaggrin Hitchhike Hornerin Selective Sweep.	FLG HRNR	1.42e-06	2	42	2	27678121
Pubmed	Control of mouse limb initiation and antero-posterior patterning by Meis transcription factors.	MEIS1 MEIS2	1.42e-06	2	42	2	34035267
Pubmed	MEIS1 and MEIS2 Expression and Prostate Cancer Progression: A Role For HOXB13 Binding Partners in Metastatic Disease.	MEIS1 MEIS2	1.42e-06	2	42	2	29716922
Pubmed	Expression of filaggrin-2 protein in the epidermis of human skin diseases: a comparative analysis with filaggrin.	FLG FLG2	1.42e-06	2	42	2	24813994
Pubmed	Variation in genes of the epidermal differentiation complex in German atopic dermatitis patients.	FLG HRNR FLG2	2.15e-06	21	42	3	19601998
Pubmed	Pbx1/Pbx2 requirement for distal limb patterning is mediated by the hierarchical control of Hox gene spatial distribution and Shh expression.	CD44 GLI3 MEIS2	2.85e-06	23	42	3	16672333
Pubmed	A novel Gli3 enhancer controls the Gli3 spatiotemporal expression pattern through a TALE homeodomain protein binding site.	GLI3 MEIS1	4.27e-06	3	42	2	21262763
Pubmed	Evidence for an evolutionary conserved role of homothorax/Meis1/2 during vertebrate retina development.	MEIS1 MEIS2	4.27e-06	3	42	2	18216174
Pubmed	DNA-dependent formation of transcription factor pairs alters their binding specificity.	MEIS1 MEIS2	4.27e-06	3	42	2	26550823
Pubmed	Conserved regulation of proximodistal limb axis development by Meis1/Hth.	MEIS1 MEIS2	4.27e-06	3	42	2	10586884
Pubmed	GATA3 regulates FLG and FLG2 expression in human primary keratinocytes.	FLG FLG2	4.27e-06	3	42	2	28928464
Pubmed	Filaggrin and filaggrin 2 processing are linked together through skin aspartic acid protease activation.	FLG FLG2	4.27e-06	3	42	2	32437351
Pubmed	Senescence is a developmental mechanism that contributes to embryonic growth and patterning.	CD44 GLI3 MEIS1	6.50e-06	30	42	3	24238961
Pubmed	Molecular profiling of the vestibular lamina highlights a key role for Hedgehog signalling.	CD44 MEIS1 MEIS2	7.19e-06	31	42	3	36971701
Pubmed	Molecular mechanism of synovial joint site specification and induction in developing vertebrate limbs.	MEIS1 MEIS2	8.53e-06	4	42	2	37272420
Pubmed	Expression patterns of homeobox genes in the mouse vomeronasal organ at postnatal stages.	MEIS1 MEIS2	8.53e-06	4	42	2	27521061
Pubmed	Esrrb directly binds to Gata6 promoter and regulates its expression with Dax1 and Ncoa3.	GATA6 ESRRB	8.53e-06	4	42	2	27601327
Pubmed	IGF2BP2 promotes the progression of ovarian endometriosis by regulating m6A-modified MEIS2 and GATA6.	GATA6 MEIS2	8.53e-06	4	42	2	36113831
Pubmed	Identification of a conserved family of Meis1-related homeobox genes.	MEIS1 MEIS2	8.53e-06	4	42	2	9049632
Pubmed	The nuclear oncoprotein TLX1/HOX11 associates with pericentromeric satellite 2 DNA in leukemic T-cells.	MEIS1 MEIS2	8.53e-06	4	42	2	16357834
Pubmed	An atlas of combinatorial transcriptional regulation in mouse and man.	GATA6 SP8 MAFB SUGP2 PRDM4 GLI3 MEIS1 MEIS2	8.74e-06	877	42	8	20211142
Pubmed	Global control of motor neuron topography mediated by the repressive actions of a single hox gene.	POU3F1 MEIS1 MEIS2	1.14e-05	36	42	3	20826310
Pubmed	Expression of Meis and Pbx genes and their protein products in the developing telencephalon: implications for regional differentiation.	MEIS1 MEIS2	1.42e-05	5	42	2	10842069
Pubmed	Hoxa2 selectively enhances Meis binding to change a branchial arch ground state.	MEIS1 MEIS2	1.42e-05	5	42	2	25640223
Pubmed	HOX cofactors expression and regulation in the human ovary.	MEIS1 MEIS2	1.42e-05	5	42	2	18973687
Pubmed	Dental Epithelial Stem Cells Express the Developmental Regulator Meis1.	MEIS1 MEIS2	1.42e-05	5	42	2	30914971
Pubmed	Transcriptional network orchestrating regional patterning of cortical progenitors.	SP8 POU3F1 MEIS2	1.45e-05	39	42	3	34921112
Pubmed	Molecular architecture of the developing mouse brain.	SP8 POU3F1 MAFB GLI3	1.98e-05	132	42	4	34321664
Pubmed	Expression of Cornified Envelope Proteins in Skin and Its Relationship with Atopic Dermatitis Phenotype.	FLG FLG2	2.13e-05	6	42	2	27304082
Pubmed	A conserved non-homeodomain Hoxa9 isoform interacting with CBP is co-expressed with the 'typical' Hoxa9 protein during embryogenesis.	MEIS1 MEIS2	2.13e-05	6	42	2	15161102
Pubmed	Early developmental arrest of mammalian limbs lacking HoxA/HoxD gene function.	GLI3 MEIS1	2.13e-05	6	42	2	15973411
Pubmed	MEIS proteins as partners of the TLX1/HOX11 oncoprotein.	MEIS1 MEIS2	2.13e-05	6	42	2	19559479
Pubmed	Inhibition of myeloid differentiation by Hoxa9, Hoxb8, and Meis homeobox genes.	MEIS1 MEIS2	2.13e-05	6	42	2	11438208
Pubmed	Heterogeneity in Oct4 and Sox2 Targets Biases Cell Fate in 4-Cell Mouse Embryos.	SOX21 ESRRB	2.13e-05	6	42	2	27015307
Pubmed	Hox/Pbx and Brn binding sites mediate Pax3 expression in vitro and in vivo.	MEIS1 MEIS2	2.13e-05	6	42	2	15465489
Pubmed	NANOG initiates epiblast fate through the coordination of pluripotency genes expression.	GATA6 SOX21 ESRRB	2.40e-05	46	42	3	35729116
Pubmed	Regulation of EphA8 gene expression by TALE homeobox transcription factors during development of the mesencephalon.	MEIS1 MEIS2	2.98e-05	7	42	2	17178831
Pubmed	Precise temporal control of the eye regulatory gene Pax6 via enhancer-binding site affinity.	MEIS1 MEIS2	2.98e-05	7	42	2	20413611
Pubmed	PBX, MEIS, and IGF-I are potential mediators of retinoic acid-induced proximodistal limb reduction defects.	MEIS1 MEIS2	2.98e-05	7	42	2	12397630
Pubmed	Interactions between HOXD and Gli3 genes control the limb apical ectodermal ridge via Fgf10.	GLI3 MEIS1	2.98e-05	7	42	2	17467687
Pubmed	An interactome perturbation framework prioritizes damaging missense mutations for developmental disorders.	SCLY DTNB SLX4 KIAA1217 PPFIA1 RNF111	3.38e-05	514	42	6	29892012
Pubmed	Genome-wide association study of the rate of cognitive decline in Alzheimer's disease.	LIPC HECW1 PDE7B	3.68e-05	53	42	3	23535033
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	CD44 ANKS6 HRNR FLG2 SUGP2 GLI3 PPFIA1	3.69e-05	777	42	7	35844135
Pubmed	Antagonism between retinoic acid and fibroblast growth factor signaling during limb development.	MEIS1 MEIS2	3.97e-05	8	42	2	23623500
Pubmed	Patterning events and specification signals in the developing hippocampus.	POU3F1 GLI3	3.97e-05	8	42	2	10498273
Pubmed	A tissue-specific, Gata6-driven transcriptional program instructs remodeling of the mature arterial tree.	GATA6 MEIS1	3.97e-05	8	42	2	28952437
Pubmed	Discovery of genes required for body axis and limb formation by global identification of retinoic acid-regulated epigenetic marks.	MEIS1 MEIS2	3.97e-05	8	42	2	32421711
Pubmed	Meis homeoproteins directly regulate Pax6 during vertebrate lens morphogenesis.	MEIS1 MEIS2	5.10e-05	9	42	2	12183364
Pubmed	Proximo-distal positional information encoded by an Fgf-regulated gradient of homeodomain transcription factors in the vertebrate limb.	MEIS1 MEIS2	5.10e-05	9	42	2	32537491
Pubmed	Temporally Distinct Roles for the Zinc Finger Transcription Factor Sp8 in the Generation and Migration of Dorsal Lateral Ganglionic Eminence (dLGE)-Derived Neuronal Subtypes in the Mouse.	SP8 MEIS2	5.10e-05	9	42	2	33230547
Pubmed	Molecular markers of neuronal progenitors in the embryonic cerebellar anlage.	MEIS1 MEIS2	5.10e-05	9	42	2	17122047
Pubmed	Macrophages restrict the nephrogenic field and promote endothelial connections during kidney development.	MEIS1 MEIS2	5.10e-05	9	42	2	30758286
Pubmed	The doublesex homolog Dmrt5 is required for the development of the caudomedial cerebral cortex in mammals.	SP8 POU3F1 GLI3	6.18e-05	63	42	3	22923088
Pubmed	Variant PRC1 competes with retinoic acid-related signals to repress Meis2 in the mouse distal forelimb bud.	MEIS1 MEIS2	6.37e-05	10	42	2	30190278
Pubmed	Spinal Inhibitory Interneuron Diversity Delineates Variant Motor Microcircuits.	SP8 MAFB	6.37e-05	10	42	2	26949184
Pubmed	A unique stylopod patterning mechanism by Shox2-controlled osteogenesis.	MEIS1 MEIS2	6.37e-05	10	42	2	27287812
Pubmed	Identification of a new family of Pbx-related homeobox genes.	MEIS1 MEIS2	6.37e-05	10	42	2	8950991
Pubmed	Genome-scale study of transcription factor expression in the branching mouse lung.	GATA6 POU3F1 MEIS1	7.43e-05	67	42	3	22711520
Pubmed	Lens morphogenesis is dependent on Pax6-mediated inhibition of the canonical Wnt/beta-catenin signaling in the lens surface ectoderm.	MEIS1 MEIS2	7.78e-05	11	42	2	20027618
Pubmed	Congenital diaphragmatic hernia candidate genes derived from embryonic transcriptomes.	GATA6 MEIS2	7.78e-05	11	42	2	22315423
Pubmed	Rostral hindbrain patterning involves the direct activation of a Krox20 transcriptional enhancer by Hox/Pbx and Meis factors.	MEIS1 MEIS2	7.78e-05	11	42	2	18787068
Pubmed	In vitro capture and characterization of embryonic rosette-stage pluripotency between naive and primed states.	POU3F1 ESRRB	7.78e-05	11	42	2	32367046
Pubmed	The role of sonic hedgehog-Gli2 pathway in the masculinization of external genitalia.	MAFB GLI3	7.78e-05	11	42	2	21586556
Pubmed	Nr5a2 is dispensable for zygotic genome activation but essential for morula development.	GATA6 ESRRB	7.78e-05	11	42	2	39361745
Pubmed	Loss of the Otx2-Binding Site in the Nanog Promoter Affects the Integrity of Embryonic Stem Cell Subtypes and Specification of Inner Cell Mass-Derived Epiblast.	GATA6 POU3F1	9.32e-05	12	42	2	27292645
Pubmed	Gli3 Regulates Vomeronasal Neurogenesis, Olfactory Ensheathing Cell Formation, and GnRH-1 Neuronal Migration.	GLI3 MEIS2	9.32e-05	12	42	2	31767679
Pubmed	Developmental origin of the neuronal subtypes that comprise the amygdalar fear circuit in the mouse.	SP8 MEIS2	9.32e-05	12	42	2	20484636
Pubmed	RNA Pol II pausing facilitates phased pluripotency transitions by buffering transcription.	GATA6 POU3F1	9.32e-05	12	42	2	35981753
Pubmed	Genome-wide association study and meta-analysis of intraocular pressure.	PDE7B MEIS2	9.32e-05	12	42	2	24002674
Pubmed	LncRNA SAMD12-AS1 promotes cell proliferation and inhibits apoptosis by interacting with NPM1.	FLG HRNR	9.32e-05	12	42	2	31406141
Pubmed	Hypomorphic mutation of the TALE gene Prep1 (pKnox1) causes a major reduction of Pbx and Meis proteins and a pleiotropic embryonic phenotype.	MEIS1 MEIS2	1.10e-04	13	42	2	16847320
Pubmed	Pax6 is regulated by Meis and Pbx homeoproteins during pancreatic development.	MEIS1 MEIS2	1.10e-04	13	42	2	17049510
Pubmed	mBtd is required to maintain signaling during murine limb development.	SP8 GLI3	1.10e-04	13	42	2	14597661
Pubmed	The Gene Regulatory Network of Lens Induction Is Wired through Meis-Dependent Shadow Enhancers of Pax6.	MEIS1 MEIS2	1.10e-04	13	42	2	27918583
Pubmed	Meis2 controls skeletal formation in the hyoid region.	MEIS1 MEIS2	1.10e-04	13	42	2	36247013
Pubmed	Loss of Gli3 and Shh function disrupts olfactory axon trajectories.	GLI3 MEIS1	1.28e-04	14	42	2	15065125
Pubmed	Genetic and physical delineation of the region overlapping the progressive motor neuropathy (pmn) locus on mouse chromosome 13.	HECW1 GLI3	1.28e-04	14	42	2	11472062
Pubmed	Range of HOX/TALE superclass associations and protein domain requirements for HOXA13:MEIS interaction.	MEIS1 MEIS2	1.28e-04	14	42	2	15617687
Pubmed	RING1 proteins contribute to early proximal-distal specification of the forelimb bud by restricting Meis2 expression.	MEIS1 MEIS2	1.28e-04	14	42	2	26674308
Pubmed	Reduced Abd-B Hox function during kidney development results in lineage infidelity.	MAFB MEIS1	1.28e-04	14	42	2	29596840
Pubmed	PRDM14 directly interacts with heat shock proteins HSP90α and glucose-regulated protein 78.	FLG HRNR	1.28e-04	14	42	2	29178343
Pubmed	Distinct temporal requirements for the homeobox gene Gsx2 in specifying striatal and olfactory bulb neuronal fates.	SP8 MEIS2	1.48e-04	15	42	2	19709628
Pubmed	Dynamic expression of MEIS1 homeoprotein in E14.5 forebrain and differentiated forebrain-derived neural stem cells.	MEIS1 MEIS2	1.48e-04	15	42	2	23756022
Pubmed	The apical ectodermal ridge is a timer for generating distal limb progenitors.	CD44 MEIS2	1.48e-04	15	42	2	18359901
Pubmed	Shox2 is required for chondrocyte proliferation and maturation in proximal limb skeleton.	MEIS1 MEIS2	1.48e-04	15	42	2	17481601
Pubmed	Embryonic retinoic acid synthesis is required for forelimb growth and anteroposterior patterning in the mouse.	GLI3 MEIS2	1.69e-04	16	42	2	12117807
Pubmed	TRIM30 modulates Interleukin-22-regulated papillary thyroid Cancer cell migration and invasion by targeting Sox17 for K48-linked Polyubiquitination.	HRNR FLG2	1.69e-04	16	42	2	31823782
Interaction	DSG1 interactions	PLEKHG4B FLG HRNR FLG2 TRIM37 SLX4	1.84e-06	184	41	6	int:DSG1
Interaction	DPRX interactions	HRNR FLG2 SLX4	6.24e-06	18	41	3	int:DPRX
Interaction	EMX1 interactions	GATA6 PRDM4 MEIS2	1.74e-05	25	41	3	int:EMX1
Cytoband	1q21.3	FLG HRNR FLG2	1.72e-04	117	42	3	1q21.3
Cytoband	7p13	HECW1 GLI3	5.93e-04	39	42	2	7p13
GeneFamily	EF-hand domain containing\|S100 fused type protein family	FLG HRNR FLG2	1.59e-07	7	31	3	1350
GeneFamily	TALE class homeoboxes and pseudogenes	MEIS1 MEIS2	9.01e-04	26	31	2	526
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	HECW1 PCLO	1.73e-03	36	31	2	823
GeneFamily	EF-hand domain containing	FLG HRNR FLG2	6.14e-03	219	31	3	863
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	GATA6 GLI3 MEIS1 KIAA1217 MEIS2	9.30e-07	189	42	5	71397e993a77d70b2eeede240bdfc7660b558987
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	GATA6 GLI3 MEIS1 KIAA1217 MEIS2	9.30e-07	189	42	5	4eea4759520c312bd17a681034d8074e47093d2b
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	GATA6 GLI3 MEIS1 KIAA1217 MEIS2	1.01e-06	192	42	5	5105e4b577408b4e1a62d0a44c23c2b830ccad88
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	GATA6 GLI3 MEIS1 KIAA1217 MEIS2	1.06e-06	194	42	5	81713e0409e8be695ba5dfdc67a997b33435dd9e
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	GATA6 GLI3 MEIS1 KIAA1217 MEIS2	1.06e-06	194	42	5	627cffe2d448e74fc5df92e74e5b922a73304137
ToppCell	5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SP8 POU3F1 FLG2 GLI3	1.97e-05	170	42	4	2d880223d01bde4bf777bd6f50b7d2768489075f
ToppCell	5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting-Basal_resting_L.0.0.0.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SP8 POU3F1 FLG2 GLI3	1.97e-05	170	42	4	0cc20322cb3e3e7bbd4daad8785c99f80e355c16
ToppCell	3'-Pediatric_IBD-SmallIntestine-Epithelial-neuro-epithelial-EC_cells_(TAC1+)\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SP8 HRNR STXBP5L PCLO	2.41e-05	179	42	4	f2e8fc975c30992611630197b79daaeef7c4211d
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_3-Exc_L2-3_LINC00507_RPL9P17\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ZNF469 PDE7B MEIS2 CCDC144NL	2.63e-05	183	42	4	1645d4a55cd8c22d6eb47fc5c6b1e576c454f111
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_3\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ZNF469 PDE7B MEIS2 CCDC144NL	2.68e-05	184	42	4	34e316ad8e7b8667cd8ad61397281802a252744f
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_3\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	POU3F1 PDE7B MEIS2 CCDC144NL	2.68e-05	184	42	4	30fddbc9696476d4d7f08e53f84ea994a4ed873a
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_3-Exc_L2-3_LINC00507_RPL9P17\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	POU3F1 PDE7B MEIS2 CCDC144NL	2.68e-05	184	42	4	96926efa220f03d0787322c9519bb9e8f64f74d0
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-kidney_interstitial_fibroblast_5\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	GLI3 MEIS1 KIAA1217 MEIS2	2.68e-05	184	42	4	c5436a8e45f471b8d1301abbe9c7879204537f52
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	GLI3 MEIS1 KIAA1217 MEIS2	2.92e-05	188	42	4	ce85a56ac27a6432421dde93a1bafa8b943244b9
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	GLI3 MEIS1 KIAA1217 MEIS2	3.04e-05	190	42	4	1f83f7f24288a3b9ab33c2e113e845dba96adc8a
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	GLI3 MEIS1 KIAA1217 MEIS2	3.04e-05	190	42	4	2306aa9dbeaef3be8484a5b236605de23cd75d4c
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	GLI3 MEIS1 KIAA1217 MEIS2	3.04e-05	190	42	4	efb757f11c2809e66ddb48a5c84f5433f111cb7c
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	GATA6 SLF2 C16orf95 MEIS1	3.04e-05	190	42	4	445952b70abffadb6ccc1ed4bbf61a88b06b73b3
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	GATA6 SLF2 C16orf95 MEIS1	3.04e-05	190	42	4	2e592323085ba9c019d678ac2a784462ab470ed9
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	GLI3 MEIS1 KIAA1217 MEIS2	3.10e-05	191	42	4	39092a0aff8097617820c59f5fea9ee2bb4f63a2
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	GLI3 MEIS1 KIAA1217 MEIS2	3.10e-05	191	42	4	a58c75e9580139fb370b498d95660f10f3a2a27b
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	GATA6 GLI3 MEIS1 MEIS2	3.10e-05	191	42	4	a6c57627077fa980b7ec1d3894b5f31bfb11b738
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-2M-Neuronal-ventral_progenitors_and_neurons_2\|Organoid-2M / Sample Type, Dataset, Time_group, and Cell type.	POU3F1 MAFB MEIS1 MEIS2	3.10e-05	191	42	4	509d17d8ee0d028757ce0f2c9b97e5875f06f0ab
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	GATA6 GLI3 MEIS1 MEIS2	3.10e-05	191	42	4	8f6d592edc32fdb901af30501d4360512334e8c2
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	GLI3 MEIS1 KIAA1217 MEIS2	3.10e-05	191	42	4	ee5f1b1c59029c46cbb1a00935c03b9317bb9da9
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	GLI3 MEIS1 KIAA1217 MEIS2	3.17e-05	192	42	4	9093a9e94a25682d109a7f6edc256a25a61103a0
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	GATA6 MEIS1 KIAA1217 MEIS2	3.17e-05	192	42	4	bc84b9ce01b4d826a682842ab8a395dac9b91183
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	GLI3 MEIS1 KIAA1217 MEIS2	3.17e-05	192	42	4	d3c1ad4667a1e223a83ca0fcd5991a0b96f1199a
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	GLI3 MEIS1 KIAA1217 MEIS2	3.17e-05	192	42	4	9ed5d49621ec1aa01716dc369bba1450b5f015f5
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	GATA6 MEIS1 KIAA1217 MEIS2	3.17e-05	192	42	4	0ab1176cfbb0de8dd1f22c6e2c41265cf6c10ee1
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	GLI3 MEIS1 KIAA1217 MEIS2	3.30e-05	194	42	4	90efdbd7f1c85fd7fd622b10340250b1d8fc1197
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	GATA6 MEIS1 KIAA1217 MEIS2	3.30e-05	194	42	4	e03ba6caed59fa64d4d9b042593469d4a6a3dc10
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	GLI3 MEIS1 KIAA1217 MEIS2	3.30e-05	194	42	4	df82cce5ebeb73740b02cf816c6df82253cfd566
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	GATA6 MEIS1 KIAA1217 MEIS2	3.30e-05	194	42	4	ba7f971fb9a19423602da60770f23d9fead4a451
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	GATA6 MEIS1 KIAA1217 MEIS2	3.30e-05	194	42	4	cf0244a29934e515446ac917d3c30672b460fb04
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	GATA6 MEIS1 KIAA1217 MEIS2	3.43e-05	196	42	4	2b36b9a40fe415917afccff99ad9c3474e087d0d
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	GLI3 MEIS1 KIAA1217 MEIS2	3.50e-05	197	42	4	b349f8e96d61a4c296af64711e11fc44459a9413
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	CD44 GATA6 MEIS1 MEIS2	3.50e-05	197	42	4	9b480f9c799a244bfee64487abd8a1bf07c9a3a2
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	GLI3 MEIS1 KIAA1217 MEIS2	3.50e-05	197	42	4	c2e390653d5dee7e731c1840cfdab41987dede9b
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Meis2-Meis2_Adamts19\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	SP8 MEIS1 MEIS2	3.63e-05	68	42	3	3a61ea2b234829632fabede72761aa6664550e56
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Meis2\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	SP8 MEIS1 MEIS2	3.63e-05	68	42	3	3c5d0d35e4d1c5506a4a490e2f93e8024294207f
ToppCell	Skin\|World / Skin and Kidney Cells in Lupus Nephritis Patients.	CD44 FLG POU3F1 MAFB	3.64e-05	199	42	4	6be1340413ee868c610b6e3f58c65b493eb22bb5
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	HECW1 STXBP5L PDE7B KIAA1217	3.64e-05	199	42	4	19a97e27a4758e794ce7246d295e112b47931a48
ToppCell	COVID-19-kidney-Fibroblast-1\|kidney / Disease (COVID-19 only), tissue and cell type	CD44 GATA6 MEIS1 MEIS2	3.64e-05	199	42	4	9503646ff1ad248181146ce767e9d12e882ec3bd
ToppCell	Neuronal-Excitatory-eA(LAMP5_LINC00507)-FREM3---L2-3\|Neuronal / cells hierarchy compared to all cells using T-Statistic	ZNF469 STXBP5L PDE7B MEIS2	3.72e-05	200	42	4	9c89e91bb630cc306a820927a36ea6fb3d13e9d7
ToppCell	control\|World / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	MEIS1 KIAA1217 MEIS2 PCLO	3.72e-05	200	42	4	97f36d2c197e03d93a1fc59949d77ae90f6e6a9a
ToppCell	Neuronal-Excitatory-eA(LAMP5_LINC00507)\|Neuronal / cells hierarchy compared to all cells using T-Statistic	ZNF469 STXBP5L PDE7B MEIS2	3.72e-05	200	42	4	0f23e72649a274043bf23e0952a9b5707c516acf
ToppCell	Tracheal\|World / Cell types per location group and 10X technology with lineage, and cell group designations	DTNB MEIS1 KIAA1217 MEIS2	3.72e-05	200	42	4	682960e28542a3d6c119047cd0131941932cfdea
ToppCell	Neuronal-Excitatory-eA(LAMP5_LINC00507)-FREM3--\|Neuronal / cells hierarchy compared to all cells using T-Statistic	ZNF469 STXBP5L PDE7B MEIS2	3.72e-05	200	42	4	96b1d2e70fbbba744fd4356a70efcf356aca9abc
ToppCell	NS-control\|NS / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	MEIS1 KIAA1217 MEIS2 PCLO	3.72e-05	200	42	4	ecbe89ff95d046155b984c8c150e0b9e7278f839
ToppCell	Neuronal-Excitatory-eA(LAMP5_LINC00507)-FREM3\|Neuronal / cells hierarchy compared to all cells using T-Statistic	ZNF469 STXBP5L PDE7B MEIS2	3.72e-05	200	42	4	ad6f1d4d7f5d7bab2ba2e4fff58c535290065c0e
ToppCell	Neuronal-Excitatory-eA(LAMP5_LINC00507)-FREM3-\|Neuronal / cells hierarchy compared to all cells using T-Statistic	ZNF469 STXBP5L PDE7B MEIS2	3.72e-05	200	42	4	8821574d17b55dfea3ca0204e6b4c0ca6b19588a
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L5_IT-L5_IT_ALM_Npw\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	POU3F1 PDE7B MEIS2	1.65e-04	113	42	3	165de4316059222f33d1e51aeff4554037c0b937
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L5_PT-L5_PT_ALM_Hpgd\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	POU3F1 LIPC MEIS2	2.27e-04	126	42	3	9b04ca8a46cc30119baf6ef27711a0b2a6b4a0c9
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L2/3_IT-L2/3_IT_ALM_Sla\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	POU3F1 PDE7B MEIS2	2.61e-04	132	42	3	ddebc0b233fdbb73ceb70187945bbed8fd273f2a
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L2/3_IT-L2/3_IT_ALM_Ptrf\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	POU3F1 PDE7B MEIS2	2.66e-04	133	42	3	a1bc34e5dda4ff4716b857931cc196f6770f58f4
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L5_PT-L5_PT_VISp_C1ql2_Cdh13\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	POU3F1 LIPC MEIS2	2.84e-04	136	42	3	1f3000d5f105c87c80f8ae1dd2264bcd7f757a9c
ToppCell	PND07-28-samps-Mesenchymal-Mesenchymal_stem_cell\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	SP8 POU3F1 AHDC1	2.91e-04	137	42	3	ed81624b9167255ce88dcf6ad7f1636376ea0525
ToppCell	PND07-28-samps-Mesenchymal-Mesenchymal_stem_cell-Mesenchymal_fibroblast\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	SP8 POU3F1 AHDC1	2.91e-04	137	42	3	47859aa25f32367461c1ec75ed9060bee430c6b7
ToppCell	facs-Thymus-nan-3m-Epithelial-epithelial_cell_of_thymus\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SP8 FLG2 C16orf95	3.10e-04	140	42	3	115bd770a9d5e6f007a9aa0eadf5dba46d500107
ToppCell	facs-Thymus-nan-3m-Epithelial\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SP8 FLG2 C16orf95	3.10e-04	140	42	3	22d126e80bf7d9c0ca6ec686b5cc66fa584a1ab6
ToppCell	facs-Thymus-nan-3m-Epithelial-TECs\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SP8 FLG2 C16orf95	3.10e-04	140	42	3	62d1ef8cb78618ed89cac7ec89d7f54de06a90c7
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L2/3_IT-L2/3_IT_ALM_Macc1_Lrg1\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	POU3F1 PDE7B MEIS2	3.23e-04	142	42	3	d08e1880425d285c4433014fe0242ac7ff7734af
ToppCell	mild_COVID-19-B_cell\|World / disease group, cell group and cell class (v2)	POU3F1 PRDM4 GLI3	3.30e-04	143	42	3	4698cc877dda9b1ef7d6f18c9adc869ef791b1d8
ToppCell	Thalamus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)\|Thalamus / BrainAtlas - Mouse McCarroll V32	SP8 CBLN3 MEIS2	3.64e-04	148	42	3	afebb64365c94b9476494bffe7c364677f19c8cf
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L2/3_IT\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	POU3F1 PDE7B MEIS2	3.64e-04	148	42	3	d5cace5605bff2bb8248fadb51f2dad7539930ba
ToppCell	Thalamus-Neuronal-Inhibitory\|Thalamus / BrainAtlas - Mouse McCarroll V32	SP8 CBLN3 MEIS2	3.64e-04	148	42	3	5f82e5ecacfd223020b8ee975c17d68c1fe6db38
ToppCell	facs-Skin-Anagen-24m-Epithelial-basal_cell_of_epidermis\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	POU3F1 MAFB SOX21	4.09e-04	154	42	3	89a94a36dfd3d75e411038f04adaf0bbab17db45
ToppCell	droplet-Liver-Npc-21m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD44 MAFB PDE7B	4.17e-04	155	42	3	5d600e159738231d0607ea1a1ebd8510fc241b36
ToppCell	Control-Epithelial_alveolar-AT_2-Differentiating_AT1\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PLEKHG4B SLX4 RNF111	4.33e-04	157	42	3	4766f7d545bf2d775390589460677519cb92f4d5
ToppCell	COPD-Epithelial-PNEC\|COPD / Disease state, Lineage and Cell class	STXBP5L MEIS2 PCLO	4.49e-04	159	42	3	6018124980c55190928409f3bf41d846a118954a
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-high_Fibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	GLI3 MEIS1 MEIS2	4.49e-04	159	42	3	cbb331eb689d8cea9e1146ba85e0a05d23301c47
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-high_Fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	GLI3 MEIS1 MEIS2	4.49e-04	159	42	3	330ecbba97d47bc818a5e8d1d84b05d056bd831e
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L5_IT-L5_IT_ALM_Pld5\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	POU3F1 PDE7B MEIS2	4.49e-04	159	42	3	a082e770fa757c4a1d3ed13d53f83297e36faf05
ToppCell	COPD-Epithelial-PNEC\|World / Disease state, Lineage and Cell class	STXBP5L MEIS2 PCLO	4.58e-04	160	42	3	cdea93317b0ebb801ddbe73bca6149ce2c727f16
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PDE7B MEIS1 MEIS2	4.66e-04	161	42	3	1b805f77790aeb8a71b08bfac2fe2eed7343258f
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-high_Fibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	GATA6 MEIS1 MEIS2	4.75e-04	162	42	3	5f009b231f21861afee9cc0c569082e1135f929c
ToppCell	Control-Epithelial-Ionocyte\|World / Disease state, Lineage and Cell class	SP8 MEIS1 PCLO	4.75e-04	162	42	3	e3b9b46ce2faff7d099502df14bbf51e9f183f8c
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-high_Fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	GATA6 MEIS1 MEIS2	4.75e-04	162	42	3	b936f8040dcd4db621ccded19237af8df7d0ed6e
ToppCell	Control-Epithelial-Ionocyte\|Control / Disease state, Lineage and Cell class	SP8 MEIS1 PCLO	4.83e-04	163	42	3	bf09fa39bf3e6b3a776d5e79c30c96df572956a3
ToppCell	343B-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	POU3F1 ANKS6 MEIS1	4.83e-04	163	42	3	0ab043b68e8739adcedda01165a3758cd0d22728
ToppCell	normal_Lung-Fibroblasts-Myofibroblasts\|Fibroblasts / Location, Cell class and cell subclass	PLEKHG4B ZNF469 KIAA1217	4.92e-04	164	42	3	9b4a6007abae992db871d9f6f731d5af724de30d
ToppCell	356C-Myeloid-Macrophage-SPP1+_Macrophage\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	SCLY ANKS6 DTNB	4.92e-04	164	42	3	d6806deabf5f5c355934387be2baae125ac33fb8
ToppCell	3'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	POU3F1 MEIS2 PCLO	5.09e-04	166	42	3	9fd9de82f98b9acdaa59ac98fb9664161514aec0
ToppCell	facs-Heart-LV-18m-Mesenchymal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	POU3F1 GLI3 MEIS1	5.37e-04	169	42	3	849a8f8509c58d65462a09c84d58b6ecdc8934f5
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	CD44 GATA6 MEIS1	5.46e-04	170	42	3	fa753cc8fbd04e63c9a303da4dc17ee2ce907f92
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	CD44 GATA6 MEIS1	5.46e-04	170	42	3	03044e1436443b28dd39d5ef4fdb25c18e3a7546
ToppCell	3'-Airway_Nasal-Immune_Myeloid_mast-Myeloid_Mast/Baso-mast_cell-Mast_cells\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CD44 CRNKL1 SLX4	5.65e-04	172	42	3	13d7117f92a92d77d6b4335ed800c585dc8b4511
ToppCell	3'-Airway_Nasal-Immune_Myeloid_mast-Myeloid_Mast/Baso-mast_cell-Mast_cells-Mast_cells_L.1.4.0.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CD44 CRNKL1 SLX4	5.65e-04	172	42	3	3d83b2f03ad3af4dae3fe6cc0a0ef356872ca94f
ToppCell	3'-Airway_Nasal-Immune_Myeloid_mast-Myeloid_Mast/Baso\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CD44 CRNKL1 SLX4	5.65e-04	172	42	3	a3d431aed12c1192e8dca1dc85b8340fb7354f8d
ToppCell	3'-Airway_Nasal-Immune_Myeloid_mast\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CD44 CRNKL1 SLX4	5.65e-04	172	42	3	028a5441242b2cc760cafc1822120180619c63ae
ToppCell	3'-Airway_Nasal-Immune_Myeloid_mast-Myeloid_Mast/Baso-mast_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CD44 CRNKL1 SLX4	5.65e-04	172	42	3	9fc70b1a143a8ec910336c23b761d908bb6aecb2
ToppCell	droplet-Thymus-nan-21m-Lymphocytic-B_cell\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD44 LIPC SLF2	5.74e-04	173	42	3	0a0cd40bb5f61431fe34758626c8a63ec610a8a5
ToppCell	facs-Brain_Non-Myeloid-Cerebellum_-18m-Epithelial-neuronal_stem_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SP8 LIPC MEIS2	5.74e-04	173	42	3	f38bf7584e08d15a6e2c116b7c3551ba475a5e14
ToppCell	(6)_Endothelial_cells-(6)_Endothelial-E\|(6)_Endothelial_cells / Lung cell shreds - cell class (v4) and cell subclass (v4)	MEIS1 KIAA1217 MEIS2	5.84e-04	174	42	3	4a1b67ce5ea353b3f81f59fa57da07668146afca
ToppCell	COVID-19-kidney-REN+Pericyte\|COVID-19 / Disease (COVID-19 only), tissue and cell type	PDE7B MEIS1 MEIS2	5.84e-04	174	42	3	8393f0b43c767839c1630bcb952d62b42efc788d
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	CD44 GATA6 MEIS2	5.94e-04	175	42	3	f0c2eb82e17e8aec2cfa5d83169178f409cc1abc
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Neuronal-interneuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CBLN3 STXBP5L DTNB	5.94e-04	175	42	3	65571d775d26a40e979dbf290a8e4320c0d9fb3f
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-kidney_interstitial_fibroblast_5\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	CD44 GATA6 MEIS2	5.94e-04	175	42	3	910a075ccaf79de22338ecf321fa0a867f3d7d75
ToppCell	3'-Pediatric_IBD-SmallIntestine-Epithelial-neuro-epithelial\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HRNR STXBP5L PCLO	6.04e-04	176	42	3	fb718a6b07aa5d56600263280afa530bcb63db42
Disease	cholesteryl esters:total lipids ratio, high density lipoprotein cholesterol measurement	GATA6 MAFB PLCB3 LIPC RNF111	1.67e-05	243	39	5	EFO_0004612, EFO_0020944
Disease	restless legs syndrome (implicated_via_orthology)	MEIS1 MEIS2	4.74e-05	8	39	2	DOID:0050425 (implicated_via_orthology)
Disease	level of Phosphatidylcholine (16:0_18:3) in blood serum	LIPC RNF111	1.32e-04	13	39	2	OBA_2045072
Disease	level of Phosphatidylethanolamine (18:1_18:1) in blood serum	LIPC RNF111	1.53e-04	14	39	2	OBA_2045142
Disease	free cholesterol measurement, very low density lipoprotein cholesterol measurement	MAFB PLCB3 LIPC RNF111	1.85e-04	215	39	4	EFO_0008317, EFO_0008591
Disease	very low density lipoprotein cholesterol measurement, lipid measurement	MAFB PLCB3 LIPC RNF111	2.02e-04	220	39	4	EFO_0004529, EFO_0008317
Disease	level of Phosphatidylethanolamine (16:0_20:4) in blood serum	LIPC RNF111	2.02e-04	16	39	2	OBA_2045137
Disease	total cholesterol measurement, very low density lipoprotein cholesterol measurement	MAFB PLCB3 LIPC RNF111	2.16e-04	224	39	4	EFO_0004574, EFO_0008317
Disease	very low density lipoprotein cholesterol measurement, phospholipid measurement	MAFB PLCB3 LIPC RNF111	2.35e-04	229	39	4	EFO_0004639, EFO_0008317
Disease	diverticular disease	SP8 HECW1 KIAA1217 PPFIA1	2.63e-04	236	39	4	EFO_0009959
Disease	level of Phosphatidylethanolamine (18:0_20:4) in blood serum	LIPC RNF111	2.87e-04	19	39	2	OBA_2045140
Disease	leukemia (implicated_via_orthology)	MEIS1 MEIS2	2.87e-04	19	39	2	DOID:1240 (implicated_via_orthology)
Disease	phospholipid measurement, intermediate density lipoprotein measurement	MAFB LIPC RNF111	3.07e-04	99	39	3	EFO_0004639, EFO_0008595
Disease	familial hyperlipidemia	MAFB LIPC SUGP2	3.75e-04	106	39	3	MONDO_0001336
Disease	very low density lipoprotein cholesterol measurement	MAFB PLCB3 LIPC RNF111	3.80e-04	260	39	4	EFO_0008317
Disease	level of Phosphatidylethanolamine (16:0_18:2) in blood serum	LIPC RNF111	4.61e-04	24	39	2	OBA_2045136
Disease	cholesterol:total lipids ratio, high density lipoprotein cholesterol measurement	GATA6 MAFB PLCB3 LIPC	4.76e-04	276	39	4	EFO_0004612, EFO_0020943
Disease	hippocampal volume	SP8 GLI3 KIAA1217 MEIS2	6.27e-04	297	39	4	EFO_0005035
Disease	level of Phosphatidylethanolamine (18:0_18:2) in blood serum	LIPC RNF111	6.30e-04	28	39	2	OBA_2045139
Disease	triglycerides:total lipids ratio, intermediate density lipoprotein measurement	GATA6 PLCB3 LIPC	6.35e-04	127	39	3	EFO_0008595, EFO_0020947
Disease	cholesterol:total lipids ratio, low density lipoprotein cholesterol measurement	MAFB PLCB3 LIPC	9.15e-04	144	39	3	EFO_0004611, EFO_0020943
Disease	colorectal adenocarcinoma (is_implicated_in)	CD44 GATA6	9.85e-04	35	39	2	DOID:0050861 (is_implicated_in)
Disease	vitamin D measurement	FLG MAFB LIPC HRNR	9.92e-04	336	39	4	EFO_0004631
Disease	triglycerides:total lipids ratio, low density lipoprotein cholesterol measurement	GATA6 PLCB3 LIPC	1.03e-03	150	39	3	EFO_0004611, EFO_0020947

Protein segments in the cluster

Peptide	Gene	Start	Entry
SSQGLGGSPGSHSHT	BARGIN	176	Q6ZT62
PHAVGGGDGDHSSTG	CCDC144NL	166	Q6NUI1
TIHGHPGSSSGGRQG	FLG	2461	P20930
GQGHSPGATAAATGL	AHDC1	211	Q5TGY3
TGSGEHGAFPVHSQG	RBAKDN	66	A6NC62
GGTPGPSSGGHTSHS	MEIS1	226	O00470
HGSGSGQSSGFGQHE	FLG2	596	Q5D862
HRSGSGQSSGFGQHG	FLG2	951	Q5D862
HGSGSDQSSGFGQHG	FLG2	1041	Q5D862
GEATGHGHSGHGQST	FLG2	1396	Q5D862
SRHGQSGSSGHGRQG	FLG2	2206	Q5D862
SGSSGHGRQGTTHGQ	FLG2	2211	Q5D862
LHNSPGSGTSGNAFH	GLI3	1231	P10071
GPHATASATAAGGNG	MAFB	191	Q9Y5Q3
GHSGGHFPSLANGAA	HECW1	631	Q76N89
STHSAGTPGPSSGGH	MEIS2	226	O14770
AAGGGASGAGSPSHT	PCLO	21	Q9Y6V0
SSGSGPDHDHAGQGT	PDE7B	426	Q9NP56
HSSGSGQSPGHGQRG	HRNR	416	Q86YZ3
GHSSGHGQHGSRSGQ	HRNR	486	Q86YZ3
HGSVSGQSSGFGHKS	HRNR	691	Q86YZ3
GSGSHQSSGHGRQGS	HRNR	756	Q86YZ3
QSSGHGRQGSGSGHS	HRNR	761	Q86YZ3
HASGRGRHGSGSGQS	HRNR	876	Q86YZ3
GSGSGHSPSRGRHGS	HRNR	1236	Q86YZ3
GRHGSGLGHSSSHGQ	HRNR	1246	Q86YZ3
GSGSGHFCSQGQHGS	HRNR	1301	Q86YZ3
GRHGSGLGHSSSHGQ	HRNR	1716	Q86YZ3
GSGSGHFCSQGQHGS	HRNR	1771	Q86YZ3
GSGSGHSPSRGRHGS	HRNR	2176	Q86YZ3
GSGSGHFCSQGQHGS	HRNR	2241	Q86YZ3
GRHGSGLGHSSSHGQ	HRNR	2656	Q86YZ3
GSGSGHFCSQGQHGS	HRNR	2711	Q86YZ3
SGQSLSHGRHGSGSG	HRNR	2766	Q86YZ3
AAAHLHPGAGGGGSS	POU3F1	226	Q03052
AHVSGFAGSSIGGTH	LIPC	171	P11150
GHGSGSPSQPDADSH	PPFIA1	21	Q13136
SVAGFGSPGSHSHTA	NUP42	341	O15504
ACASNGHAPGSSGHL	PLCB3	1206	Q01970
GHAPGSSGHLSGADS	PLCB3	1211	Q01970
AAGPGGAGSAAAHVS	GATA6	246	Q92908
AQPGHHGNGAASVTA	CRNKL1	96	Q9BZJ0
QDTFHPSGGSHTTHG	CD44	606	P16070
PSGGSHTTHGSESDG	CD44	611	P16070
AQATGSPHTSPTHGG	DTNB	526	O60941
ANSGNFNHSPHSSGG	ANKS6	626	Q68DC2
FNHSPHSSGGSSGVG	ANKS6	631	Q68DC2
HSSGGSSGVGVSRHG	ANKS6	636	Q68DC2
HHEPAGETGNGTSGA	CBLN3	81	Q6UW01
SQHHGASPGAGTSAG	ARRDC1-AS1	86	Q9H2J1
HHEATGAASGAAAGG	C16orf95	16	Q9H693
SHHSPSGSSDASGGF	ESRRB	31	O95718
LPTQGHSGSHGPSHS	PRDM4	571	Q9UKN5
AGPAGSSHGYVGSSS	TRIM37	581	O94972
AAAAGGHTHSHPSPG	SOX21	216	Q9Y651
AHTSGQPFHSTGAPG	KIAA1217	856	Q5T5P2
GLAPSNSGNSGHHST	SLF2	406	Q8IX21
SNSGGGAGSGSVHPA	STXBP5L	26	Q9Y2K9
GGSSAHSQDGSHQPV	SP8	146	Q8IXZ3
QGGSPRGSHHTSGSS	SLX4	1041	Q8IY92
ANQTSKGHTGGHHSP	SCLY	116	Q96I15
NSGGRSPDTHSGGHS	RBMXL3	521	Q8N7X1
SHGSGSFHGASAFDP	RNF111	576	Q6ZNA4
TSHHSAGSRPGGHLG	PLEKHG4B	101	Q96PX9
SPHNLHTGGGDTTGS	SUGP2	846	Q8IX01
GHGVASSHSPAGGIL	nan	161	A8MX80
ASGGGSSSPGSPVHH	SKOR2	846	Q2VWA4
GASPSHAAQGHSAGR	ZNF469	1796	Q96JG9
GHGVASSHSPAGGIL	nan	131	A8MV72
GHGVASSHSPAGGIL	nan	161	Q8N9G6
GHGVASSHSPAGGIL	nan	161	A8MUA0
SKGHGVASSHSPAGG	nan	196	Q5PR19