Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiontranscription coactivator activity

MED7 SMARCE1 HCFC1 BRD4 RERE

2.61e-05303245GO:0003713
GeneOntologyMolecularFunctiontranscription coregulator activity

MED7 SMARCE1 HCFC1 BRD4 RERE

4.73e-04562245GO:0003712
GeneOntologyCellularComponentmidbody

KIF20A SPART IL16 DCDC1

1.11e-04222244GO:0030496
PathwayREACTOME_RUNX1_INTERACTS_WITH_CO_FACTORS_WHOSE_PRECISE_EFFECT_ON_RUNX1_TARGETS_IS_NOT_KNOWN

AUTS2 SMARCE1

5.81e-0434152MM15531
PathwayREACTOME_RUNX1_INTERACTS_WITH_CO_FACTORS_WHOSE_PRECISE_EFFECT_ON_RUNX1_TARGETS_IS_NOT_KNOWN

AUTS2 SMARCE1

6.89e-0437152M27797
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

KIF20A ZFHX4 SMARCE1 IL16 BRD4 GIGYF1 RERE DCDC1

5.10e-07111624831753913
Pubmed

WW domains provide a platform for the assembly of multiprotein networks.

SPART SMARCE1 SF3A1 BRD4

3.67e-0615424416055720
Pubmed

Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.

KIF20A XIRP1 IL16 YARS1 GIGYF1 LPP

5.87e-0668924636543142
Pubmed

Spatiotemporal-resolved protein networks profiling with photoactivation dependent proximity labeling.

SPART SMARCE1 HCFC1 SF3A1 BRD4

6.88e-0639924535987950
Pubmed

Chromatin accessibility complex subunit 1 enhances tumor growth by regulating the oncogenic transcription of YAP in breast and cervical cancer.

HCFC1 SF3A1 BRD4

8.24e-065724338223760
Pubmed

A novel p53 regulator, C16ORF72/TAPR1, buffers against telomerase inhibition.

KIF20A ZFHX4 AUTS2 YARS1 RERE

9.99e-0643124533660365
Pubmed

ASXL3 bridges BRD4 to BAP1 complex and governs enhancer activity in small cell lung cancer.

HCFC1 BRD4

2.05e-051024232669118
Pubmed

Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.

SMARCE1 HCFC1 BRD4 RERE

3.24e-0526824433640491
Pubmed

N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.

C1orf52 SPART SMARCE1 HCFC1 SF3A1 LPP

3.28e-0593424633916271
Pubmed

Human transcription factor protein interaction networks.

ZFHX4 AUTS2 SMARCE1 HCFC1 MYL6B GIGYF1 RERE

3.64e-05142924735140242
Pubmed

A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening.

HCFC1 SF3A1

4.13e-051424210976766
Pubmed

Variant of TYR and autoimmunity susceptibility loci in generalized vitiligo.

RERE LPP

4.77e-051524220410501
Pubmed

Interaction network of human early embryonic transcription factors.

ZFHX4 AUTS2 SMARCE1 RERE

9.24e-0535124438297188
Pubmed

BioID identifies novel c-MYC interacting partners in cultured cells and xenograft tumors.

SMARCE1 HCFC1 BRD4

1.07e-0413424325452129
Pubmed

HIV-1 Vpr induces cell cycle arrest and enhances viral gene expression by depleting CCDC137.

HCFC1 SF3A1 BRD4

1.43e-0414824332538781
Pubmed

Glioma tumor suppressor candidate region gene 1 (GLTSCR1) and its paralog GLTSCR1-like form SWI/SNF chromatin remodeling subcomplexes.

SMARCE1 BRD4

1.59e-042724229374058
Pubmed

Transcription factor protein interactomes reveal genetic determinants in heart disease.

SMARCE1 HCFC1 SF3A1 BRD4

1.69e-0441124435182466
Pubmed

An Oct4-centered protein interaction network in embryonic stem cells.

MED7 SMARCE1 HCFC1

2.04e-0416724320362541
Pubmed

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.

ZFHX4 SMARCE1 HCFC1 SF3A1 YARS1

2.59e-0485724525609649
Pubmed

Direct recruitment of polycomb repressive complex 1 to chromatin by core binding transcription factors.

SMARCE1 HCFC1

2.68e-043524222325351
Pubmed

Gene expression profile of the human trabecular meshwork: NEIBank sequence tag analysis.

LAPTM4A RERE

2.99e-043724212766061
Pubmed

Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations.

LPP DCDC1

2.99e-043724222797727
Pubmed

An AUTS2-Polycomb complex activates gene expression in the CNS.

AUTS2 RERE

3.16e-043824225519132
Pubmed

Oct4 links multiple epigenetic pathways to the pluripotency network.

SMARCE1 HCFC1 BRD4

3.62e-0420324322083510
Pubmed

Impact of WIN site inhibitor on the WDR5 interactome.

HCFC1 RERE

4.05e-044324233472061
Pubmed

Characterizing WW domain interactions of tumor suppressor WWOX reveals its association with multiprotein networks.

SPART SMARCE1 SF3A1

4.58e-0422024324550385
Pubmed

TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation.

SMARCE1 HCFC1 RERE

4.58e-0422024335785414
Pubmed

SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.

SMARCE1 HCFC1 BRD4 LPP

5.08e-0454924438280479
Pubmed

KAP1 targets actively transcribed genomic loci to exert pleomorphic effects on RNA polymerase II activity.

SMARCE1 SF3A1

5.48e-045024232068487
InteractionSMARCB1 interactions

KIF20A SMARCE1 HCFC1 SF3A1 IL16 BRD4

2.59e-06364236int:SMARCB1
InteractionRNF2 interactions

KIF20A AUTS2 SMARCE1 SF3A1 MYL6B BRD4 LPP

3.54e-05866237int:RNF2
InteractionATN1 interactions

AUTS2 HCFC1 GIGYF1 RERE

5.54e-05187234int:ATN1
InteractionWWTR1 interactions

SMARCE1 HCFC1 IL16 BRD4 LPP

9.69e-05422235int:WWTR1
InteractionERG interactions

ZFHX4 SMARCE1 BRD4 RERE

1.10e-04223234int:ERG
InteractionSNRPC interactions

HCFC1 SF3A1 BRD4 GIGYF1 RERE

1.18e-04440235int:SNRPC
InteractionKANSL3 interactions

HCFC1 BRD4 RERE

1.25e-0486233int:KANSL3
InteractionGSC interactions

ZFHX4 AUTS2 RERE

1.29e-0487233int:GSC
InteractionMED25 interactions

MED7 HCFC1 BRD4

1.58e-0493233int:MED25
InteractionRERE interactions

AUTS2 HCFC1 RERE

1.58e-0493233int:RERE
InteractionZNF608 interactions

AUTS2 HCFC1 RERE

1.58e-0493233int:ZNF608
InteractionHDAC1 interactions

KIF20A ZFHX4 SMARCE1 HCFC1 SF3A1 BRD4 RERE

1.68e-041108237int:HDAC1
InteractionKAT8 interactions

HCFC1 BRD4 RERE

1.68e-0495233int:KAT8
InteractionKIFC3 interactions

KIF20A SMARCE1 IL16 GIGYF1

1.75e-04252234int:KIFC3
InteractionMAD2L1 interactions

KIF20A C1orf52 SF3A1 BRD4

1.75e-04252234int:MAD2L1
InteractionSNRPA interactions

HCFC1 SF3A1 BRD4 YARS1 GIGYF1

1.81e-04482235int:SNRPA
InteractionTFCP2L1 interactions

SMARCE1 HCFC1 BRD4

1.90e-0499233int:TFCP2L1
InteractionSNRPB interactions

KIF20A HCFC1 SF3A1 BRD4 GIGYF1

2.50e-04517235int:SNRPB
InteractionHAPSTR1 interactions

KIF20A ZFHX4 AUTS2 SF3A1 YARS1 RERE

2.63e-04829236int:HAPSTR1
InteractionRBFOX2 interactions

KIF20A MED7 SF3A1 RERE

2.77e-04284234int:RBFOX2
InteractionTBR1 interactions

KIF20A ZFHX4 BRD4

2.80e-04113233int:TBR1
InteractionRBBP5 interactions

SMARCE1 HCFC1 BRD4 RERE

2.88e-04287234int:RBBP5
InteractionACTL6A interactions

MED7 SMARCE1 SF3A1 BRD4

2.96e-04289234int:ACTL6A
InteractionHDAC2 interactions

KIF20A SMARCE1 HCFC1 BRD4 RERE LPP

3.31e-04865236int:HDAC2
InteractionRBM14 interactions

KIF20A AUTS2 SMARCE1 SF3A1 BRD4

3.41e-04553235int:RBM14
Diseaseautoimmune thyroid disease

GIGYF1 RERE LPP

1.44e-04126243EFO_0006812
Diseaseallergic rhinitis

SMARCE1 RERE LPP

1.69e-04133243EFO_0005854
Diseaserespiratory system disease

SMARCE1 RERE LPP

2.18e-04145243EFO_0000684
Diseaseblood pressure, chronic obstructive pulmonary disease

FAM13A RERE

3.10e-0432242EFO_0000341, EFO_0004325
Diseaseopen-angle glaucoma

FAM13A RERE LPP

4.89e-04191243EFO_0004190
DiseaseEczema, allergic rhinitis

SMARCE1 RERE LPP

6.90e-04215243EFO_0005854, HP_0000964
Diseaseeosinophil percentage of granulocytes

SMARCE1 RERE LPP

8.81e-04234243EFO_0007996
Diseaselymphocyte count

AUTS2 SMARCE1 IL16 GIGYF1 RERE LPP

9.18e-041464246EFO_0004587
Diseasebasophil count, eosinophil count

SMARCE1 RERE LPP

9.59e-04241243EFO_0004842, EFO_0005090
Diseaseallergic disease

SMARCE1 RERE LPP

1.17e-03258243MONDO_0005271
Diseasesynophrys measurement

ZFHX4 AUTS2

1.40e-0368242EFO_0007906
Diseaseallergic disease, age at onset

SMARCE1 LPP

1.52e-0371242EFO_0004847, MONDO_0005271
Diseasehypothyroidism

MED7 GIGYF1 LPP

1.54e-03284243EFO_0004705
Diseaseage of onset of asthma

RERE LPP

1.88e-0379242OBA_2001001
Diseaseasthma, allergic disease

SMARCE1 RERE

1.88e-0379242MONDO_0004979, MONDO_0005271
DiseaseEczema

SMARCE1 RERE LPP

1.97e-03310243HP_0000964
Diseasechildhood onset asthma

SMARCE1 RERE LPP

2.44e-03334243MONDO_0005405
DiseaseInhalant adrenergic use measurement

RERE LPP

2.76e-0396242EFO_0009941
Diseaseeosinophil percentage of leukocytes

SMARCE1 SF3A1 RERE LPP

2.88e-03746244EFO_0007991
Diseaseattention deficit hyperactivity disorder, unipolar depression, bipolar disorder, autism spectrum disorder, schizophrenia

CLEC17A RERE

3.05e-03101242EFO_0003756, EFO_0003761, EFO_0003888, MONDO_0004985, MONDO_0005090
DiseaseVitiligo

RERE LPP

3.05e-03101242EFO_0004208
Diseaseaspartate aminotransferase measurement, serum alanine aminotransferase measurement, low density lipoprotein triglyceride measurement, body fat percentage, high density lipoprotein cholesterol measurement, sex hormone-binding globulin measurement

FAM13A AUTS2 RERE

3.11e-03364243EFO_0004612, EFO_0004696, EFO_0004735, EFO_0004736, EFO_0007800, EFO_0009946
Diseaselymphocyte measurement

GIGYF1 RERE

4.06e-03117242EFO_0803546
Diseaseasthma, Eczema, allergic rhinitis

SMARCE1 LPP

4.34e-03121242EFO_0005854, HP_0000964, MONDO_0004979
DiseasePolyarthritis, Juvenile, Rheumatoid Factor Positive

RERE LPP

5.06e-03131242C4704862
DiseasePolyarthritis, Juvenile, Rheumatoid Factor Negative

RERE LPP

5.06e-03131242C4552091
DiseaseJuvenile arthritis

RERE LPP

5.06e-03131242C3495559
DiseaseJuvenile psoriatic arthritis

RERE LPP

5.06e-03131242C3714758
DiseaseJuvenile-Onset Still Disease

RERE LPP

5.37e-03135242C0087031
Diseasecardiovascular disease

SMARCE1 RERE DCDC1

5.87e-03457243EFO_0000319
Diseaseeosinophil count

SMARCE1 SF3A1 GIGYF1 RERE LPP

6.17e-031488245EFO_0004842

Protein segments in the cluster

PeptideGeneStartEntry
KEPAPMKSKPPPTYE

BRD4

586

O60885
YTTEKKPPPPELDMA

C1orf52

111

Q8N6N3
DLPPPPSKAPMKKEN

HCFC1

1796

P51610
PMKKPICKTTEPYAP

DCDC1

921

M0R2J8
PIKAKPQYKPPDDKM

MAP6

316

Q96JE9
SVASPPPSPAMPKYK

GIGYF1

21

O75420
EMAVKMPEKEPPPPY

LAPTM4A

216

Q15012
APKPPPPIKDSYMMF

MED7

31

O43513
KPMSSKPKPPPRKYF

IL16

591

Q14005
PPSPKPMKMKNYNKP

MT-ATP8

36

P03928
MPTPAPPMFDKYPTK

AUTS2

556

Q8WXX7
PPKKFAPVVAPKPKY

LPP

41

Q93052
RDMPKPPPKTKIPKS

FAM13A

271

O94988
YPDPSKQKPMAKGPA

YARS1

341

P54577
PTKKPNSDIYPKPKP

XG

36

P55808
KPPKPPDKPLMPYMR

SMARCE1

61

Q969G3
EKPVDPPPFMFKPVK

RERE

546

Q9P2R6
KDYDPKASKPLPPAP

SF3A1

391

Q15459
TPPYKDLPPKPGTME

CLEC17A

56

Q6ZS10
RIPYPDMEPKPATKK

ZNF624

121

Q9P2J8
PKLYPEFPPKDMCEK

SPART

111

Q8N0X7
KPEPEKTSPKPEYPA

ZFHX4

2351

Q86UP3
MPPKKDVPVKKPAGP

MYL6B

1

P14649
HKYQKMLEPPPSAKP

KIF20A

711

O95235
TPKLDPTMPPKKKPQ

XIRP1

1311

Q702N8
PEKKPPPKIAWPMKF

PIFO

136

Q8TCI5