Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	structural constituent of skin epidermis	KRT81 KRT83 KRT86 KRT87P	3.17e-05	43	84	4	GO:0030280
GeneOntologyMolecularFunction	cysteine-type peptidase activity	CSTL1 USP24 CASP2 USP20 USP33 BAP1	1.59e-04	192	84	6	GO:0008234
GeneOntologyBiologicalProcess	siRNA-mediated heterochromatin formation	TDRD5 MOV10L1 TDRD12	1.01e-05	11	83	3	GO:0141194
GeneOntologyBiologicalProcess	transposable element silencing by siRNA-mediated heterochromatin formation	TDRD5 MOV10L1 TDRD12	1.01e-05	11	83	3	GO:0141007
GeneOntologyBiologicalProcess	transposable element silencing by heterochromatin formation	TDRD5 MOV10L1 TDRD12	4.91e-05	18	83	3	GO:0141005
GeneOntologyBiologicalProcess	ectopic germ cell programmed cell death	INSL6 CASP2 IL1B	7.93e-05	21	83	3	GO:0035234
GeneOntologyBiologicalProcess	piRNA processing	TDRD5 MOV10L1 TDRD12	9.16e-05	22	83	3	GO:0034587
GeneOntologyBiologicalProcess	regulatory ncRNA-mediated heterochromatin formation	TDRD5 MOV10L1 TDRD12	1.05e-04	23	83	3	GO:0031048
HumanPheno	Perifollicular hyperkeratosis	KRT81 KRT83 KRT86	1.08e-06	4	34	3	HP:0007468
HumanPheno	Abnormal perifollicular morphology	KRT81 KRT83 KRT86	5.36e-06	6	34	3	HP:0031285
MousePheno	abnormal Purkinje cell dendrite morphology	DAB2IP SACS ZNF212 ATM HERC2	1.17e-05	58	72	5	MP:0008572
Domain	TPR_REGION	NPHP3 TRANK1 TTC14 DNAH2 UNC45A ZC3H7B TTC4 FEM1A	7.03e-07	165	83	8	PS50293
Domain	TPR	NPHP3 TRANK1 TTC14 DNAH2 UNC45A ZC3H7B TTC4 FEM1A	7.03e-07	165	83	8	PS50005
Domain	Coatomer/calthrin_app_sub_C	AP4E1 AP1B1 AP2B1	4.66e-06	8	83	3	IPR009028
Domain	-	AP1B1 AP2B1	1.95e-05	2	83	2	2.60.40.1150
Domain	Clathrin_b-adaptin_app_Ig-like	AP1B1 AP2B1	1.95e-05	2	83	2	IPR013037
Domain	TPR	NPHP3 TRANK1 TTC14 UNC45A ZC3H7B TTC4	2.36e-05	129	83	6	SM00028
Domain	TPR_repeat	NPHP3 TRANK1 TTC14 UNC45A ZC3H7B TTC4	2.80e-05	133	83	6	IPR019734
Domain	Clathrin/coatomer_adapt-like_N	AP4E1 AP1B1 AP2B1	3.70e-05	15	83	3	IPR002553
Domain	Adaptin_N	AP4E1 AP1B1 AP2B1	3.70e-05	15	83	3	PF01602
Domain	-	NPHP3 TRANK1 TTC14 UNC45A ZC3H7B TTC4 FEM1A	3.78e-05	207	83	7	1.25.40.10
Domain	TPR_1	NPHP3 TTC14 UNC45A ZC3H7B TTC4	5.02e-05	90	83	5	PF00515
Domain	TPR_1	NPHP3 TTC14 UNC45A ZC3H7B TTC4	5.02e-05	90	83	5	IPR001440
Domain	TPR-contain_dom	NPHP3 TRANK1 TTC14 UNC45A ZC3H7B TTC4	5.51e-05	150	83	6	IPR013026
Domain	AP_complex_bsu_1_2_4	AP1B1 AP2B1	5.84e-05	3	83	2	IPR016342
Domain	B2-adapt-app_C	AP1B1 AP2B1	5.84e-05	3	83	2	PF09066
Domain	TPR-like_helical_dom	NPHP3 TRANK1 TTC14 UNC45A ZC3H7B TTC4 FEM1A	7.98e-05	233	83	7	IPR011990
Domain	B-adaptin_app_sub_C	AP1B1 AP2B1	1.16e-04	4	83	2	IPR015151
Domain	Taxilin	TXLNG TXLNGY	1.16e-04	4	83	2	PF09728
Domain	B2-adapt-app_C	AP1B1 AP2B1	1.16e-04	4	83	2	SM01020
Domain	ARM-type_fold	AP4E1 VAC14 AP1B1 AP2B1 PI4KA USP24 ATM UNC45A	1.31e-04	339	83	8	IPR016024
Domain	Keratin_2_head	KRT81 KRT83 KRT86	1.60e-04	24	83	3	IPR032444
Domain	Keratin_2_head	KRT81 KRT83 KRT86	1.60e-04	24	83	3	PF16208
Domain	AP_beta	AP1B1 AP2B1	1.93e-04	5	83	2	IPR026739
Domain	Keratin_II	KRT81 KRT83 KRT86	2.04e-04	26	83	3	IPR003054
Domain	DUSP	USP20 USP33	2.89e-04	6	83	2	SM00695
Domain	DUSP	USP20 USP33	2.89e-04	6	83	2	PF06337
Domain	Beta2_adaptin/TBP_C_dom	AP1B1 AP2B1	2.89e-04	6	83	2	IPR012295
Domain	-	AP1B1 AP2B1	2.89e-04	6	83	2	3.30.310.10
Domain	Tudor	TDRD5 ARID4B TDRD12	3.15e-04	30	83	3	IPR002999
Domain	-	USP20 USP33	4.04e-04	7	83	2	3.30.2230.10
Domain	DUSP	USP20 USP33	4.04e-04	7	83	2	PS51283
Domain	Pept_C19_DUSP	USP20 USP33	4.04e-04	7	83	2	IPR006615
Domain	Clathrin_a/b/g-adaptin_app_Ig	AP1B1 AP2B1	6.88e-04	9	83	2	IPR008152
Domain	Alpha_adaptinC2	AP1B1 AP2B1	6.88e-04	9	83	2	PF02883
Domain	Alpha_adaptinC2	AP1B1 AP2B1	6.88e-04	9	83	2	SM00809
Domain	Elongated_TPR_rpt_dom	UNC45A TTC4	1.05e-03	11	83	2	IPR023114
Domain	ZnF_UBP	USP20 USP33	1.05e-03	11	83	2	SM00290
Domain	Armadillo	AP1B1 AP2B1 UNC45A	1.19e-03	47	83	3	IPR000225
Domain	Coatomer/clathrin_app_Ig-like	AP1B1 AP2B1	1.25e-03	12	83	2	IPR013041
Domain	TPR_2	NPHP3 TTC14 UNC45A	1.43e-03	50	83	3	PF07719
Domain	TPR_2	NPHP3 TTC14 UNC45A	1.43e-03	50	83	3	IPR013105
Domain	TUDOR	TDRD5 TDRD12	1.72e-03	14	83	2	PF00567
Domain	Znf_UBP	USP20 USP33	1.72e-03	14	83	2	IPR001607
Domain	zf-UBP	USP20 USP33	1.72e-03	14	83	2	PF02148
Domain	ZF_UBP	USP20 USP33	1.72e-03	14	83	2	PS50271
Domain	PI3/4_kinase_CS	PI4KA ATM	1.97e-03	15	83	2	IPR018936
Domain	-	PI4KA ATM	2.25e-03	16	83	2	1.10.1070.11
Domain	PI3Kc	PI4KA ATM	2.25e-03	16	83	2	SM00146
Domain	Intermediate_filament_CS	KRT81 KRT83 KRT86	2.77e-03	63	83	3	IPR018039
Domain	PI3/4_kinase_cat_dom	PI4KA ATM	2.85e-03	18	83	2	IPR000403
Domain	PI3_PI4_kinase	PI4KA ATM	2.85e-03	18	83	2	PF00454
Domain	PI3_4_KINASE_3	PI4KA ATM	2.85e-03	18	83	2	PS50290
Domain	PI3_4_KINASE_1	PI4KA ATM	2.85e-03	18	83	2	PS00915
Domain	PI3_4_KINASE_2	PI4KA ATM	2.85e-03	18	83	2	PS00916
Domain	-	AP4E1 VAC14 AP1B1 AP2B1 UNC45A	3.11e-03	222	83	5	1.25.10.10
Domain	USP_CS	USP24 USP20 USP33	3.17e-03	66	83	3	IPR018200
Domain	LIM	LMX1A PDLIM7 FHL5	3.59e-03	69	83	3	PF00412
Domain	-	LMX1A PDLIM7 FHL5	3.74e-03	70	83	3	2.10.110.10
Domain	USP_1	USP24 USP20 USP33	3.74e-03	70	83	3	PS00972
Domain	Znf_LIM	LMX1A PDLIM7 FHL5	3.89e-03	71	83	3	IPR001781
Domain	LIM_DOMAIN_1	LMX1A PDLIM7 FHL5	3.89e-03	71	83	3	PS00478
Domain	UCH	USP24 USP20 USP33	3.89e-03	71	83	3	PF00443
Domain	USP_2	USP24 USP20 USP33	3.89e-03	71	83	3	PS00973
Domain	LIM_DOMAIN_2	LMX1A PDLIM7 FHL5	3.89e-03	71	83	3	PS50023
Domain	Filament	KRT81 KRT83 KRT86	3.89e-03	71	83	3	SM01391
Domain	LIM	LMX1A PDLIM7 FHL5	3.89e-03	71	83	3	SM00132
Domain	IF	KRT81 KRT83 KRT86	4.05e-03	72	83	3	PS00226
Domain	USP_3	USP24 USP20 USP33	4.05e-03	72	83	3	PS50235
Domain	USP_dom	USP24 USP20 USP33	4.05e-03	72	83	3	IPR028889
Domain	Peptidase_C19_UCH	USP24 USP20 USP33	4.05e-03	72	83	3	IPR001394
Domain	Filament	KRT81 KRT83 KRT86	4.21e-03	73	83	3	PF00038
Pubmed	Novel KRT83 and KRT86 mutations associated with monilethrix.	KRT81 KRT83 KRT86	1.41e-08	3	85	3	25557232
Pubmed	Structure and site of expression of a murine type II hair keratin.	KRT81 KRT83 KRT86	1.41e-08	3	85	3	1372089
Pubmed	Transient expression of mouse hair keratins in transfected HeLa cells: interactions between "hard" and "soft" keratins.	KRT81 KRT83 KRT86	1.41e-08	3	85	3	1712823
Pubmed	Characterization of a 300 kbp region of human DNA containing the type II hair keratin gene domain.	KRT81 KRT83 KRT86 KRT87P	1.62e-08	12	85	4	10692104
Pubmed	Keratins of the human hair follicle.	KRT81 KRT83 KRT86	5.63e-08	4	85	3	15797458
Pubmed	ATM binds to beta-adaptin in cytoplasmic vesicles.	AP1B1 AP2B1 ATM	5.63e-08	4	85	3	9707615
Pubmed	Comprehensive analysis of keratin gene clusters in humans and rodents.	KRT81 KRT83 KRT86 KRT87P	5.91e-08	16	85	4	15085952
Pubmed	PERP regulates enamel formation via effects on cell-cell adhesion and gene expression.	KRT81 KRT83 KRT86 KRT87P	1.25e-07	19	85	4	21285247
Pubmed	Caspase-2 deficiency prevents programmed germ cell death resulting from cytokine insufficiency but not meiotic defects caused by loss of ataxia telangiectasia-mutated (Atm) gene function.	CASP2 ATM IL1B	4.90e-07	7	85	3	11536012
Pubmed	A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies.	DAB2IP ARID4B GAPDH KRT81 CSTL1 KRT83 KRT86 KRT87P	5.00e-07	284	85	8	29459677
Pubmed	Charting the molecular network of the drug target Bcr-Abl.	AP1B1 AP2B1 GAPDH KRT81 KRT83 KRT86 PSTPIP2	4.20e-06	266	85	7	19380743
Pubmed	Macrophages regulates the transition of pericyte to peritoneal fibrosis through the GSDMD/IL-1β axis.	GSDMD IL1B	5.90e-06	2	85	2	34749292
Pubmed	A missense mutation in the type II hair keratin hHb3 is associated with monilethrix.	KRT83 KRT86	5.90e-06	2	85	2	15744029
Pubmed	Maternal Western diet mediates susceptibility of offspring to Crohn's-like colitis by deoxycholate generation.	GSDMD IL1B	5.90e-06	2	85	2	37131223
Pubmed	Expression of BAP1 and ATM proteins: Association with AJCC tumor category in uveal melanoma.	ATM BAP1	5.90e-06	2	85	2	31864162
Pubmed	Analysis of Association between MAP2K4 Gene Polymorphism rs3826392 and IL-1b Serum Level in Southern Chinese Han Ischemic Stroke Patients.	MAP2K4 IL1B	5.90e-06	2	85	2	26856463
Pubmed	Macrophages promote growth, migration and epithelial-mesenchymal transition of renal cell carcinoma by regulating GSDMD/IL-1β axis.	GSDMD IL1B	5.90e-06	2	85	2	36057231
Pubmed	A variable monilethrix phenotype associated with a novel mutation, Glu402Lys, in the helix termination motif of the type II hair keratin hHb1.	KRT81 KRT86	5.90e-06	2	85	2	9665406
Pubmed	Physical and functional interaction of the HECT ubiquitin-protein ligases E6AP and HERC2.	UBE3A HERC2	5.90e-06	2	85	2	21493713
Pubmed	ATM and Artemis promote homologous recombination of radiation-induced DNA double-strand breaks in G2.	DCLRE1C ATM	5.90e-06	2	85	2	19779458
Pubmed	A new mutation in the type II hair cortex keratin hHb1 involved in the inherited hair disorder monilethrix.	KRT81 KRT86	5.90e-06	2	85	2	9402962
Pubmed	Deubiquitinases USP20/33 promote the biogenesis of tail-anchored membrane proteins.	USP20 USP33	5.90e-06	2	85	2	33792613
Pubmed	Gasdermin D promotes development of intestinal tumors through regulating IL-1β release and gut microbiota composition.	GSDMD IL1B	5.90e-06	2	85	2	39434144
Pubmed	Loss of caspase-2 augments lymphomagenesis and enhances genomic instability in Atm-deficient mice.	CASP2 ATM	5.90e-06	2	85	2	24248351
Pubmed	Apoptosis signaling triggered by the marine alkaloid ascididemin is routed via caspase-2 and JNK to mitochondria.	MAP2K4 CASP2	5.90e-06	2	85	2	14716300
Pubmed	Artemis-dependent DNA double-strand break formation at stalled replication forks.	DCLRE1C ATM	5.90e-06	2	85	2	23465063
Pubmed	Radiation-induced double-strand breaks require ATM but not Artemis for homologous recombination during S-phase.	DCLRE1C ATM	5.90e-06	2	85	2	22730303
Pubmed	Endogenously induced DNA double strand breaks arise in heterochromatic DNA regions and require ataxia telangiectasia mutated and Artemis for their repair.	DCLRE1C ATM	5.90e-06	2	85	2	21596788
Pubmed	Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.	DAB2IP AP1B1 AP2B1 SACS PI4KA CNKSR2 EPB41L1	6.01e-06	281	85	7	28706196
Pubmed	Rapamycin Inhibited Pyroptosis and Reduced the Release of IL-1β and IL-18 in the Septic Response.	GSDMD IL1B	1.77e-05	3	85	2	32851082
Pubmed	Functional intersection of ATM and DNA-dependent protein kinase catalytic subunit in coding end joining during V(D)J recombination.	DCLRE1C ATM	1.77e-05	3	85	2	23836881
Pubmed	NLRP3-GSDMD-dependent IL-1β Secretion from Microglia Mediates Learning and Memory Impairment in a Chronic Intermittent Hypoxia-induced Mouse Model.	GSDMD IL1B	1.77e-05	3	85	2	38154620
Pubmed	TDRD5 binds piRNA precursors and selectively enhances pachytene piRNA processing in mice.	TDRD5 MOV10L1	1.77e-05	3	85	2	29317670
Pubmed	Identification of a deubiquitinating enzyme subfamily as substrates of the von Hippel-Lindau tumor suppressor.	USP20 USP33	1.77e-05	3	85	2	12056827
Pubmed	NudC-like protein 2 restrains centriole amplification by stabilizing HERC2.	HERC2 USP33	1.77e-05	3	85	2	31427565
Pubmed	Degradation of the deubiquitinating enzyme USP33 is mediated by p97 and the ubiquitin ligase HERC2.	HERC2 USP33	1.77e-05	3	85	2	24855649
Pubmed	Microparticulate P2X7 and GSDM-D mediated regulation of functional IL-1β release.	GSDMD IL1B	1.77e-05	3	85	2	30547277
Pubmed	Hydroxysafflor Yellow A Inhibits LPS-Induced NLRP3 Inflammasome Activation via Binding to Xanthine Oxidase in Mouse RAW264.7 Macrophages.	XDH IL1B	1.77e-05	3	85	2	27433030
Pubmed	A hypomorphic Artemis human disease allele causes aberrant chromosomal rearrangements and tumorigenesis.	DCLRE1C ATM	1.77e-05	3	85	2	21147755
Pubmed	Elucidating the mechanism of IL-1β-Mediated Piezo1 expression regulation of chondrocyte autophagy and apoptosis via the PI3K/AKT/mTOR signaling Pathway.	PIEZO1 IL1B	1.77e-05	3	85	2	38134572
Pubmed	The tumor suppressor, TAX1BP2, is a novel substrate of ATM kinase.	VAC14 ATM	1.77e-05	3	85	2	24240686
Pubmed	HERC2-USP20 axis regulates DNA damage checkpoint through Claspin.	HERC2 USP20	1.77e-05	3	85	2	25355518
Pubmed	Induction of apoptosis by the mouse Nedd2 gene, which encodes a protein similar to the product of the Caenorhabditis elegans cell death gene ced-3 and the mammalian IL-1 beta-converting enzyme.	GAPDH CASP2	1.77e-05	3	85	2	7958843
Pubmed	Sequence data and chromosomal localization of human type I and type II hair keratin genes.	KRT81 KRT86	1.77e-05	3	85	2	7556444
Pubmed	Mincle-GSDMD-mediated release of IL-1β small extracellular vesicles from hepatic macrophages in ethanol-induced liver injury.	GSDMD IL1B	1.77e-05	3	85	2	37185170
Pubmed	Deubiquitination of type 2 iodothyronine deiodinase by von Hippel-Lindau protein-interacting deubiquitinating enzymes regulates thyroid hormone activation.	USP20 USP33	1.77e-05	3	85	2	12865408
Pubmed	IL-1β turnover by the UBE2L3 ubiquitin conjugating enzyme and HECT E3 ligases limits inflammation.	UBE3A IL1B	1.77e-05	3	85	2	37474493
Pubmed	Sequences and differential expression of three novel human type-II hair keratins.	KRT83 KRT86	1.77e-05	3	85	2	9084137
Pubmed	Post-translational control of IL-1β via the human papillomavirus type 16 E6 oncoprotein: a novel mechanism of innate immune escape mediated by the E3-ubiquitin ligase E6-AP and p53.	UBE3A IL1B	1.77e-05	3	85	2	23935506
Pubmed	The colonic pathogen Entamoeba histolytica activates caspase-4/1 that cleaves the pore-forming protein gasdermin D to regulate IL-1β secretion.	GSDMD IL1B	1.77e-05	3	85	2	35303042
Pubmed	New consensus nomenclature for mammalian keratins.	KRT81 KRT83 KRT86 KRT87P	1.77e-05	63	85	4	16831889
Pubmed	ZFP628 Is a TAF4b-Interacting Transcription Factor Required for Mouse Spermiogenesis.	TDRD5 MOV10L1 FHL5	1.82e-05	21	85	3	31932482
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	AP4E1 GAPDH TRPM7 SLFN13 ZC3H4 PI4KA ADAMTS16 CNKSR2 MPHOSPH9 ADD3	2.02e-05	777	85	10	35844135
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	DAB2IP MAP2K4 AP1B1 AP2B1 UBE3A ZC3H4 PI4KA CNKSR2 HERC2 EPB41L1 WDR47	2.28e-05	963	85	11	28671696
Pubmed	DYRK1a mediates BAFF-induced noncanonical NF-κB activation to promote autoimmunity and B-cell leukemogenesis.	KRT81 KRT83 KRT86 KRT87P	2.69e-05	70	85	4	34255829
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	KNTC1 RIMKLB NPHP3 SACS TTC14 ADAMTS16 FGD6 USP20	2.85e-05	493	85	8	15368895
Pubmed	Defining the human deubiquitinating enzyme interaction landscape.	CUL2 AP2B1 KRT81 CNKSR2 MPHOSPH9 UNC45A HERC2 FEM1A USP20 USP33 BAP1	3.37e-05	1005	85	11	19615732
Pubmed	Ubiquitin-specific peptidase 20 targets TRAF6 and human T cell leukemia virus type 1 tax to negatively regulate NF-kappaB signaling.	USP20 USP33	3.53e-05	4	85	2	21525354
Pubmed	Phosphorylation of USP20 on Ser334 by IRAK1 promotes IL-1β-evoked signaling in vascular smooth muscle cells and vascular inflammation.	IL1B USP20	3.53e-05	4	85	2	37311534
Pubmed	HERC2/USP20 coordinates CHK1 activation by modulating CLASPIN stability.	HERC2 USP20	3.53e-05	4	85	2	25326330
Pubmed	A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci.	DCLRE1C ATM	3.53e-05	4	85	2	15574327
Pubmed	Association of epidermal growth factor receptors with coated pit adaptins via a tyrosine phosphorylation-regulated mechanism.	AP1B1 AP2B1	3.53e-05	4	85	2	7534311
Pubmed	Nonredundancy of IL-1α and IL-1β is defined by distinct regulation of tissues orchestrating resistance versus tolerance to infection.	GSDMD IL1B	3.53e-05	4	85	2	35235356
Pubmed	Role of activation of PIP5Kgamma661 by AP-2 complex in synaptic vesicle endocytosis.	AP1B1 AP2B1	3.53e-05	4	85	2	17290217
Pubmed	Testicular expression of TDRD1, TDRD5, TDRD9 and TDRD12 in azoospermia.	TDRD5 TDRD12	3.53e-05	4	85	2	32059713
Pubmed	Role of the ubiquitin ligase E6AP/UBE3A in controlling levels of the synaptic protein Arc.	SACS UBE3A	3.53e-05	4	85	2	23671107
Pubmed	Artemis links ATM to G2/M checkpoint recovery via regulation of Cdk1-cyclin B.	DCLRE1C ATM	3.53e-05	4	85	2	17242184
Pubmed	Characterization and chromosomal localization of human hair-specific keratin genes and comparative expression during the hair growth cycle.	KRT81 KRT86	3.53e-05	4	85	2	9457912
Pubmed	The deubiquitinases USP33 and USP20 coordinate beta2 adrenergic receptor recycling and resensitization.	USP20 USP33	3.53e-05	4	85	2	19424180
Pubmed	Ribosomes guide pachytene piRNA formation on long intergenic piRNA precursors.	TDRD5 MOV10L1	3.53e-05	4	85	2	32015435
Pubmed	Gasdermin D pore structure reveals preferential release of mature interleukin-1.	GSDMD IL1B	3.53e-05	4	85	2	33883744
Pubmed	Genetic polymorphisms, their allele combinations and IFN-beta treatment response in Irish multiple sclerosis patients.	CASP2 ITGA4 IL1B	3.95e-05	27	85	3	19604093
Pubmed	TDRD5 is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis in mice.	TDRD5 GAPDH FHL5	4.92e-05	29	85	3	21383078
Pubmed	The receptor-type protein tyrosine phosphatase CD45 promotes onset and severity of IL-1β-mediated autoinflammatory osteomyelitis.	PSTPIP2 IL1B	5.87e-05	5	85	2	34461100
Pubmed	N-GSDMD trafficking to neutrophil organelles facilitates IL-1β release independently of plasma membrane pores and pyroptosis.	GSDMD IL1B	5.87e-05	5	85	2	32371889
Pubmed	PIDD death-domain phosphorylation by ATM controls prodeath versus prosurvival PIDDosome signaling.	CASP2 ATM	5.87e-05	5	85	2	22854598
Pubmed	Critical role for inflammasome-independent IL-1β production in osteomyelitis.	PSTPIP2 IL1B	5.87e-05	5	85	2	24395792
Pubmed	ROCK activity affects IL-1-induced signaling possibly through MKK4 and p38 MAPK in Caco-2 cells.	MAP2K4 IL1B	5.87e-05	5	85	2	27173611
Pubmed	NLRP3 selectively drives IL-1β secretion by Pseudomonas aeruginosa infected neutrophils and regulates corneal disease severity.	GSDMD IL1B	5.87e-05	5	85	2	37730693
Pubmed	DNA-PKcs and Artemis function in the end-joining phase of immunoglobulin heavy chain class switch recombination.	DCLRE1C ATM	5.87e-05	5	85	2	18316419
Pubmed	DNA double strand break repair enzymes function at multiple steps in retroviral infection.	DCLRE1C ATM	5.87e-05	5	85	2	20003485
Pubmed	Endocytosis of the glucose transporter GLUT8 is mediated by interaction of a dileucine motif with the beta2-adaptin subunit of the AP-2 adaptor complex.	AP1B1 AP2B1	5.87e-05	5	85	2	16723738
Pubmed	HERC2 Facilitates BLM and WRN Helicase Complex Interaction with RPA to Suppress G-Quadruplex DNA.	UBE3A HERC2 USP20	6.03e-05	31	85	3	30279242
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	AP2B1 SACS TRPM7 UBE3A KRT83 ZNF84 ATM HERC2 TXLNG ADD3 USP33 WDR47	6.71e-05	1285	85	12	35914814
Pubmed	Ubiquitin-specific peptidase 2a (USP2a) deubiquitinates and stabilizes β-catenin.	USP20 USP33 BAP1	7.29e-05	33	85	3	30323974
Pubmed	The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.	DAB2IP TRPM7 PI4KA TTC4 FGD6 TXLNG EPB41L1 ADD3	7.79e-05	569	85	8	30639242
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	DAB2IP VAC14 ZNF276 PI4KA PIEZO1 ARHGAP26 NPRL3 HERC2 ZC3H7B FEM1A BAP1	7.89e-05	1105	85	11	35748872
Pubmed	Expression of the Bcl-2 protein BAD promotes prostate cancer growth.	MAP2K4 CASP2 IL1B	7.98e-05	34	85	3	19593445
Pubmed	Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia.	DCLRE1C CASP2 ATM ITGA4 IL1B	8.03e-05	179	85	5	19074885
Pubmed	Angelman syndrome-associated point mutations in the Zn2+-binding N-terminal (AZUL) domain of UBE3A ubiquitin ligase inhibit binding to the proteasome.	UBE3A PSMB1 HERC2	8.71e-05	35	85	3	30257870
Pubmed	The HERC2 ubiquitin ligase is essential for embryonic development and regulates motor coordination.	HERC2 USP33	8.80e-05	6	85	2	27528230
Pubmed	Gasdermin D-mediated release of IL-33 from senescent hepatic stellate cells promotes obesity-associated hepatocellular carcinoma.	GSDMD IL1B	8.80e-05	6	85	2	35749514
Pubmed	Gasdermin E permits interleukin-1 beta release in distinct sublytic and pyroptotic phases.	GSDMD IL1B	8.80e-05	6	85	2	33852854
Pubmed	Clathrin.	AP1B1 AP2B1	8.80e-05	6	85	2	10966473
Pubmed	Similar subunit interactions contribute to assembly of clathrin adaptor complexes and COPI complex: analysis using yeast three-hybrid system.	AP4E1 AP1B1	8.80e-05	6	85	2	11409905
Pubmed	Multiple sclerosis susceptibility genes: associations with relapse severity and recovery.	MPHOSPH9 RGS1	8.80e-05	6	85	2	24130709
Pubmed	Formation of dynamic gamma-H2AX domains along broken DNA strands is distinctly regulated by ATM and MDC1 and dependent upon H2AX densities in chromatin.	DCLRE1C ATM	8.80e-05	6	85	2	19450528
Pubmed	Dietary modulation of the microbiome affects autoinflammatory disease.	PSTPIP2 IL1B	8.80e-05	6	85	2	25274309
Pubmed	USP33 regulates centrosome biogenesis via deubiquitination of the centriolar protein CP110.	USP20 USP33	8.80e-05	6	85	2	23486064
Pubmed	Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant.	DAB2IP AP1B1 ARHGAP26 HERC2 EPB41L1 ADD3 WDR47	9.06e-05	430	85	7	32581705
Interaction	RASGEF1B interactions	DAB2IP PDLIM7 ARHGAP26 CHN2	7.43e-06	30	85	4	int:RASGEF1B
Interaction	LPXN interactions	DAB2IP PDLIM7 ARHGAP26 PSTPIP2 ITGA4 CHN2	9.18e-06	115	85	6	int:LPXN
Cytoband	12q13	KRT81 KRT83 KRT86 KRT87P	9.67e-06	71	85	4	12q13
GeneFamily	Tetratricopeptide repeat domain containing\|Bardet-Biedl syndrome associated\|BBSome	NPHP3 TRANK1 TTC14 ZC3H7B TTC4	3.07e-05	115	57	5	769
GeneFamily	Keratins, type II	KRT81 KRT83 KRT86	8.24e-05	27	57	3	609
GeneFamily	Ubiquitin specific peptidases	USP24 USP20 USP33	7.31e-04	56	57	3	366
CoexpressionAtlas	dev gonad_e13.5_F_MeioticGermCell_Oct_top-relative-expression-ranked_500	KNTC1 TDRD5 RIMKLB TRANK1 MOV10L1 CNKSR2 ATM FGD6 TXLNG TDRD12	2.56e-06	385	83	10	gudmap_dev gonad_e13.5_F_MeioticGermCell_Oct_500
CoexpressionAtlas	dev gonad_e12.5_F_GermCellOvary_Oct_top-relative-expression-ranked_500	CUL2 KNTC1 TDRD5 RIMKLB MOV10L1 ATM FGD6 TXLNG TDRD12	2.95e-05	406	83	9	gudmap_dev gonad_e12.5_F_GermCellOvary_Oct_500
CoexpressionAtlas	FacebaseRNAseq_e10.5_Medial Nasal Eminence_top-relative-expression-ranked_2500_k-means-cluster#4	ZNF276 ARID4B TRPM7 GSDMD ARHGAP26 TTC14 DNAH2 CNKSR2 MPHOSPH9 PSTPIP2 FGD6 EPB41L1	3.10e-05	744	83	12	Facebase_RNAseq_e10.5_Medial Nasal Eminence_2500_K4
CoexpressionAtlas	NK cells, NK.MCMV7.Sp, CD3-,NK1.1+, Spleen, avg-3	DAB2IP LRRC8C INSL6 XDH ITGA4 CHN2 RGS1 DENND4C ADD3	3.24e-05	411	83	9	GSM538312_500
CoexpressionAtlas	dev gonad_e13.5_F_MeioticGermCell_Oct_top-relative-expression-ranked_1000	CUL2 KNTC1 TDRD5 RIMKLB TRANK1 TAF9B MOV10L1 CNKSR2 ATM FGD6 TXLNG TDRD12	7.91e-05	820	83	12	gudmap_dev gonad_e13.5_F_MeioticGermCell_Oct_1000
CoexpressionAtlas	dev gonad_e12.5_M_GermCellTestis_Oct_top-relative-expression-ranked_500	CUL2 KNTC1 TDRD5 RIMKLB MOV10L1 ATM TXLNG TDRD12	1.36e-04	387	83	8	gudmap_dev gonad_e12.5_M_GermCellTestis_Oct_500
CoexpressionAtlas	dev gonad_e13.5_M_GermCell_Oct_top-relative-expression-ranked_500	CUL2 TDRD5 RIMKLB TAF9B MOV10L1 ATM TXLNG TDRD12	1.59e-04	396	83	8	gudmap_dev gonad_e13.5_M_GermCell_Oct_500
CoexpressionAtlas	FacebaseRNAseq_e10.5_Medial Nasal Eminence_top-relative-expression-ranked_1000_k-means-cluster#4	ARID4B TRPM7 ARHGAP26 MOV10L1 TTC14 MPHOSPH9 FGD6	1.67e-04	298	83	7	Facebase_RNAseq_e10.5_Medial Nasal Eminence_1000_K4
CoexpressionAtlas	DevelopingGonad_e14.5_ ovary_emap-6699_top-relative-expression-ranked_1000	SACS UBE3A ARHGAP26 MOV10L1 ADAMTS16 ATM THSD7B TXLNG ADD3 WDR47 TDRD12	2.12e-04	776	83	11	gudmap_developingGonad_e14.5_ ovary_1000
CoexpressionAtlas	dev gonad_e13.5_F_MeioticGermCell_Oct_top-relative-expression-ranked_200	RIMKLB TRANK1 MOV10L1 TXLNG TDRD12	2.46e-04	143	83	5	gudmap_dev gonad_e13.5_F_MeioticGermCell_Oct_200
ToppCell	T_cells-Resident_memory_CD8+_T_cells\|T_cells / Immune cells in Kidney/Urine in Lupus Nephritis	DAB2IP KRT81 KRT86 ARHGAP26 CHN2 USP20	1.35e-06	182	85	6	111d434b89902ec11fb07f41b8ee1a98f3991b61
ToppCell	T_cells-Resident_memory_CD8+_T_cells\|World / Immune cells in Kidney/Urine in Lupus Nephritis	DAB2IP KRT81 KRT86 ARHGAP26 CHN2 USP20	1.44e-06	184	85	6	e04cabff33a8e36967622ec3e5b37b89afa7e148
ToppCell	facs-Lung-EPCAM-3m-Lymphocytic-NK_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	INSL6 KRT81 KRT86 CHN2 RGS1	1.12e-05	153	85	5	2a94092937267cd2282452dfde3d328d763d4294
ToppCell	facs-Lung-EPCAM-3m-Lymphocytic-Natural_Killer\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	INSL6 KRT81 KRT86 CHN2 RGS1	1.12e-05	153	85	5	ad33c81fe6ac10e7c263d42541aae0d796923bad
ToppCell	facs-Brain_Myeloid-Cortex-24m-Myeloid-macrophage\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARHGAP26 XDH PSTPIP2 ITGA4 IL1B	1.16e-05	154	85	5	1e088b0d4a44267f46a9b643f46a1aba784686b1
ToppCell	facs-Brain_Myeloid-Striatum_-18m-Myeloid-macrophage\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDLIM7 KRT86 XDH ITGA4 IL1B	1.27e-05	157	85	5	9d4308312301cb922f156a7b6aededc9e1c62807
ToppCell	droplet-Limb_Muscle-nan-3m-Myeloid-unknown\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TDRD5 TRANK1 PI4KA CNKSR2 RGS1	1.66e-05	166	85	5	0a7992bc673fca546636563ec3fc17a4298ab6b1
ToppCell	Posterior_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Synpr-Inhibitory_Neuron.Gad1Gad2.Synpr-Nnat_(Neuron.Gad1Gad2.Synpr-Nnat)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	MYO3A MOV10L1 THSD7B TDRD12	2.14e-05	85	85	4	642755ed2b562dd5e599a04a2b9730e8d29aefe8
ToppCell	Posterior_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Synpr-Inhibitory_Neuron.Gad1Gad2.Synpr-Nnat_(Neuron.Gad1Gad2.Synpr-Nnat)-\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	MYO3A MOV10L1 THSD7B TDRD12	2.14e-05	85	85	4	2429bacccd103e5b2414264b4aff3103ed9d7cec
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-elicited_macrophage-Monocyte-derived_macrophage-Monocyte-derived_macrophage_L.1.2.3.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ARHGAP26 MPHOSPH9 PSTPIP2 IL1B RGS1	2.26e-05	177	85	5	f28243b51be104cb3adcde63f03fc2206ed3121e
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-CD4/CD8-CD8_NK_sig\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SLFN13 KRT81 ATM ITGA4 ADD3	2.87e-05	186	85	5	71e87c4c755ab607689cb050f5a363cb520a0f53
ToppCell	Nasal_Brush-Immune-Neutrophils\|Immune / Tissue, Lineage and Cell class of Lung Cells from 10X	ZNF354A TRPM7 PI4KA CFAP221 USP20	2.87e-05	186	85	5	f5aa91dbef29f7efa2b9a728c6539d7541340cd4
ToppCell	3'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_T/NK-CD8-positive,_alpha-beta_T_cell-CD8_T_cells-CD8_T_cells_L.1.1.5.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	KRT81 KRT83 KRT86 ITGA4 RGS1	3.18e-05	190	85	5	ce049630ed69d31f00acbc1b5b0896efc592121f
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_myocytic\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	MYO3A GAPDH PDLIM7 ITGA4 FHL5	3.51e-05	194	85	5	67f5e2f05a8de2213ab80d5ea16fdee121684633
ToppCell	distal-Hematologic-Natural_Killer_T-3\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	KRT81 KRT83 KRT86 ITGA4 RGS1	3.69e-05	196	85	5	05d2a15ba702b07ef59c55891a06da02cdd15f7f
ToppCell	distal-Hematologic-Natural_Killer_T\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	KRT81 KRT83 KRT86 ITGA4 RGS1	3.78e-05	197	85	5	5cb1b45f5dc8fbd9e54db9c943450ce2cc7000e4
ToppCell	Parenchymal-10x5prime-Immune_Lymphocytic-NK-ILC-T_NK-NK_CD56bright\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	SLFN13 KRT81 KRT86 ITGA4 RGS1	4.06e-05	200	85	5	580fbf9fcb78357a081e5f5af06113ca33d44581
Computational	Neighborhood of MLL	TAF9B ZNF212 TTC14 CASP2 ZNF84 USP33	7.96e-05	174	45	6	GCM_MLL
Computational	Neighborhood of PTK2	ARHGAP26 CNKSR2 ZNF84 HERC2 USP33	3.30e-04	145	45	5	GCM_PTK2
Drug	ATBI	GALK2 KRT81 KRT83 KRT86	4.83e-07	18	83	4	CID000505862
Drug	Cinnarizine [298-57-7]; Down 200; 10.8uM; PC3; HT_HG-U133A	VAC14 PDLIM7 ZNF84 ATM UNC45A ZC3H7B EPB41L1 BAP1	6.66e-07	199	83	8	5817_DN
Drug	Tiratricol, 3,3',5-triiodothyroacetic acid [51-24-1]; Down 200; 6.4uM; HL60; HG-U133A	ARID4B AP1B1 AP2B1 CASP2 ATM ITGA4 RGS1	6.80e-06	193	83	7	1412_DN
Drug	rottlerin; Down 200; 10uM; MCF7; HT_HG-U133A_EA	CUL2 ZNF276 PDLIM7 MPHOSPH9 ZC3H7B ADD3 USP33	8.03e-06	198	83	7	914_DN
Drug	Levocabastine hydrochloride [79547-78-7]; Up 200; 8.8uM; PC3; HT_HG-U133A	GALK2 UBE3A CEP112 MPHOSPH9 UNC45A ZC3H7B TXLNG	8.30e-06	199	83	7	7249_UP
Drug	melicopicine	KRT81 KRT83	1.31e-05	2	83	2	CID000101253
Drug	tebuquine	KRT81 KRT83	1.31e-05	2	83	2	CID000071991
Drug	3,5-di-O-galloylquinic acid	KRT81 KRT83	1.31e-05	2	83	2	CID000460896
Drug	sulfonamide-3	KRT81 KRT83	3.93e-05	3	83	2	CID009847197
Drug	Amitryptiline hydrochloride [549-18-8]; Down 200; 12.8uM; HL60; HT_HG-U133A	PDLIM7 ARHGAP26 CASP2 ATM UNC45A ZC3H7B	6.52e-05	188	83	6	1865_DN
Drug	ICI 182,780; Down 200; 0.01uM; MCF7; HT_HG-U133A	CUL2 VAC14 GALK2 MPHOSPH9 PSTPIP2 EPB41L1	6.71e-05	189	83	6	6997_DN
Drug	0179445-0000 [211246-22-9]; Down 200; 10uM; PC3; HT_HG-U133A	KNTC1 VAC14 ATM CHN2 USP20 BAP1	7.12e-05	191	83	6	4289_DN
Drug	Kaempferol [520-18-3]; Down 200; 14uM; PC3; HT_HG-U133A	DCLRE1C CEP112 ZNF212 CASP2 ATM UNC45A	7.54e-05	193	83	6	5839_DN
Drug	Heliotrine [303-33-3]; Down 200; 12.8uM; PC3; HT_HG-U133A	ZNF276 PDLIM7 ARHGAP26 ATM UNC45A ZC3H7B	7.75e-05	194	83	6	3717_DN
Drug	Tolfenamic acid [13710-19-5]; Down 200; 15.2uM; HL60; HG-U133A	AP1B1 NPRL3 CASP2 ITGA4 ZC3H7B RGS1	7.75e-05	194	83	6	1437_DN
Drug	phentolamine; Up 200; 11.5uM; MCF7; HT_HG-U133A_EA	DCLRE1C PDLIM7 NPRL3 MPHOSPH9 ATM PSTPIP2	7.75e-05	194	83	6	1138_UP
Drug	Lactupicrin	KRT81 KRT83	7.84e-05	4	83	2	CID000174880
Drug	lactucin	KRT81 KRT83	7.84e-05	4	83	2	CID000442266
Drug	pyriproxyfen	KRT81 KRT83 KRT86	7.85e-05	23	83	3	CID000091753
Drug	(-)-depudecin; Down 200; 1uM; MCF7; HT_HG-U133A_EA	CUL2 ZNF276 PDLIM7 USP24 CASP2 ATM	8.21e-05	196	83	6	874_DN
Drug	LY 294002; Down 200; 0.1uM; MCF7; HT_HG-U133A_EA	UBE3A ZNF268 NPRL3 ATM EPB41L1 USP33	8.21e-05	196	83	6	1054_DN
Drug	Alverine citrate salt [5560-59-8]; Down 200; 8.4uM; PC3; HT_HG-U133A	VAC14 GALK2 PDLIM7 NPRL3 ZNF84 ZC3H7B	8.21e-05	196	83	6	2110_DN
Drug	Yohimbine hydrochloride [65-19-0]; Down 200; 10.2uM; MCF7; HT_HG-U133A	GALK2 PDLIM7 ARHGAP26 CASP2 ATM EPB41L1	8.21e-05	196	83	6	2755_DN
Drug	Flunarizine dihydrochloride [30484-77-6]; Up 200; 8.4uM; PC3; HT_HG-U133A	GALK2 USP24 XDH ZNF84 UNC45A ZC3H7B	8.21e-05	196	83	6	7252_UP
Drug	Paroxetine maleate [64006-44-6]; Down 200; 1uM; PC3; HT_HG-U133A	ZNF276 GALK2 PIEZO1 USP24 CASP2 ATM	8.44e-05	197	83	6	4556_DN
Drug	Gemfibrozil [25812-30-0]; Down 200; 16uM; HL60; HG-U133A	USP24 ITGA4 ZC3H7B IL1B RGS1 ADD3	8.44e-05	197	83	6	1430_DN
Drug	Epiandrosterone [481-29-8]; Up 200; 13.8uM; HL60; HT_HG-U133A	AP4E1 PDLIM7 CASP2 XDH UNC45A CHN2	8.44e-05	197	83	6	2444_UP
Drug	Benzydamine hydrochloride [132-69-4]; Down 200; 11.6uM; PC3; HT_HG-U133A	ARHGAP26 CASP2 ATM UNC45A ZC3H7B WDR47	8.44e-05	197	83	6	5811_DN
Drug	Clindamycin hydrochloride [21462-39-5]; Down 200; 8.6uM; PC3; HT_HG-U133A	PDLIM7 CASP2 ZNF84 ATM UNC45A ZC3H7B	8.44e-05	197	83	6	5815_DN
Drug	Methiothepin maleate [19728-88-2]; Down 200; 8.4uM; MCF7; HT_HG-U133A	AP4E1 PDLIM7 CASP2 ZC3H7B USP20 EPB41L1	8.68e-05	198	83	6	5413_DN
Drug	Triamterene [396-01-0]; Up 200; 15.8uM; HL60; HT_HG-U133A	PDLIM7 ARHGAP26 XDH ZC3H7B CHN2 FHL5	8.68e-05	198	83	6	1861_UP
Drug	Epitiostanol [2363-58-8]; Down 200; 13uM; MCF7; HT_HG-U133A	VAC14 NPRL3 ATM UNC45A DENND4C EPB41L1	8.68e-05	198	83	6	4788_DN
Drug	quercetin dihydrate; Down 200; 1uM; MCF7; HT_HG-U133A_EA	CUL2 ZNF268 PDLIM7 ATM ZC3H7B EPB41L1	8.68e-05	198	83	6	917_DN
Drug	Heptaminol hydrochloride [543-15-7]; Up 200; 22uM; PC3; HT_HG-U133A	GALK2 PDLIM7 ARHGAP26 NPRL3 CASP2 UNC45A	8.68e-05	198	83	6	7313_UP
Drug	Xamoterol hemifumarate [73210-73-8]; Up 200; 5uM; MCF7; HT_HG-U133A	CUL2 AP2B1 PDLIM7 NPRL3 PSTPIP2 IL1B	8.68e-05	198	83	6	5363_UP
Drug	Practolol [6673-35-4]; Down 200; 15uM; PC3; HT_HG-U133A	GALK2 PDLIM7 USP24 CASP2 UNC45A EPB41L1	8.92e-05	199	83	6	4603_DN
Drug	Merbromin [129-16-8]; Down 200; 5uM; PC3; HT_HG-U133A	PDLIM7 PSMB1 CASP2 ZC3H7B TXLNG EPB41L1	8.92e-05	199	83	6	7398_DN
Drug	Lorglumide sodium salt [97964-56-2]; Down 200; 8.4uM; HL60; HT_HG-U133A	CUL2 AP4E1 GALK2 PDLIM7 PSMB1 NPRL3	8.92e-05	199	83	6	3079_DN
Drug	sulfur mustard	KRT81 KRT83 KRT86 CASP2 IL1B	1.14e-04	130	83	5	CID000010461
Drug	AC1NSBNC	GALK2 GAPDH	1.30e-04	5	83	2	CID005357915
Disease	MONILETHRIX	KRT81 KRT83 KRT86	1.92e-08	3	80	3	158000
Disease	Beaded hair	KRT81 KRT83 KRT86	1.92e-08	3	80	3	cv:C0546966
Disease	monilethrix (is_implicated_in)	KRT81 KRT83 KRT86	1.92e-08	3	80	3	DOID:0050472 (is_implicated_in)
Disease	Monilethrix	KRT81 KRT83 KRT86	7.66e-08	4	80	3	C0546966
Disease	hair disease (is_implicated_in)	KRT81 KRT86	7.26e-06	2	80	2	DOID:421 (is_implicated_in)
Disease	Ovarian Serous Adenocarcinoma	MYO3A MAP2K4 TRPM7	3.27e-05	23	80	3	C1335177
Disease	oral squamous cell carcinoma (biomarker_via_orthology)	GAPDH IL1B	4.34e-05	4	80	2	DOID:0050866 (biomarker_via_orthology)
Disease	Neoplasm of uncertain or unknown behavior of breast	MAP2K4 HERC2 BAP1	1.90e-04	41	80	3	C0496956
Disease	Breast adenocarcinoma	MAP2K4 HERC2 BAP1	1.90e-04	41	80	3	C0858252
Disease	pancreatic cancer (is_implicated_in)	MAP2K4 ATM ITGA4 IL1B	2.49e-04	112	80	4	DOID:1793 (is_implicated_in)
Disease	Gout	XDH IL1B	2.58e-04	9	80	2	C0018099
Disease	hair colour measurement	ZNF276 PIEZO1 KRT86 HERC2 KRT87P RGS1 EPB41L1 ADD3	2.64e-04	615	80	8	EFO_0007822
Disease	osteoarthritis	ZNF276 ZNF268 MPHOSPH9 THSD7B TDRD12	3.50e-04	222	80	5	MONDO_0005178
Disease	hypertension (implicated_via_orthology)	ADAMTS16 XDH IL1B ADD3	4.14e-04	128	80	4	DOID:10763 (implicated_via_orthology)
Disease	Pulmonary Thromboembolisms	DAB2IP XDH	4.71e-04	12	80	2	C0524702
Disease	Pulmonary Embolism	DAB2IP XDH	4.71e-04	12	80	2	C0034065
Disease	chronic kidney disease (implicated_via_orthology)	XDH IL1B	4.71e-04	12	80	2	DOID:784 (implicated_via_orthology)
Disease	chronic kidney disease (is_implicated_in)	XDH IL1B	6.47e-04	14	80	2	DOID:784 (is_implicated_in)
Disease	Conventional (Clear Cell) Renal Cell Carcinoma	MYO3A CASP2 ATM BAP1	7.15e-04	148	80	4	C0279702
Disease	laryngeal squamous cell carcinoma (is_marker_for)	MAP2K4 XDH	1.20e-03	19	80	2	DOID:2876 (is_marker_for)
Disease	epilepsy (biomarker_via_orthology)	GAPDH IL1B	1.47e-03	21	80	2	DOID:1826 (biomarker_via_orthology)
Disease	proprotein convertase subtilisin/kexin type 9 measurement	USP24 CNKSR2	1.62e-03	22	80	2	EFO_0009312
Disease	portal hypertension (biomarker_via_orthology)	XDH IL1B	1.62e-03	22	80	2	DOID:10762 (biomarker_via_orthology)
Disease	Degenerative polyarthritis	GAPDH PSMB1 IL1B	2.09e-03	93	80	3	C0029408
Disease	Osteoarthrosis Deformans	GAPDH PSMB1 IL1B	2.09e-03	93	80	3	C0086743
Disease	Myocardial Infarction	DAB2IP ATM IL1B	2.22e-03	95	80	3	C0027051
Disease	diffusing capacity of the lung for carbon monoxide	LMX1A KRT86 KRT87P	2.29e-03	96	80	3	EFO_0009369
Disease	acute kidney failure (implicated_via_orthology)	XDH IL1B	2.44e-03	27	80	2	DOID:3021 (implicated_via_orthology)
Disease	status epilepticus (biomarker_via_orthology)	CASP2 ATM IL1B	2.57e-03	100	80	3	DOID:1824 (biomarker_via_orthology)
Disease	Pancreatic Neoplasm	MAP2K4 ATM BAP1	2.57e-03	100	80	3	C0030297
Disease	gastric adenocarcinoma (is_marker_for)	MAP2K4 IL1B	2.62e-03	28	80	2	DOID:3717 (is_marker_for)
Disease	prostate carcinoma in situ (is_marker_for)	MAP2K4 ATM	2.62e-03	28	80	2	DOID:8634 (is_marker_for)

Protein segments in the cluster

Peptide	Gene	Start	Entry
KSSLRFLKCCYTKLP	TDRD5	571	Q8NAT2
KDEKYSPKNCKLRRL	ARID4B	651	Q4LE39
LRKCLKDEDPYVRKT	AP2B1	126	P63010
VKGEKLTRCKLASLY	ADD3	131	Q9UEY8
KPRYKCVNLSIKDIL	GSDMD	51	P57764
KICEVYSKKSPVSLD	CEP112	186	Q8N8E3
KYSPKELLALLKCVE	BAP1	626	Q92560
LRKCLKDEDPYVRKT	AP1B1	126	Q10567
KYRELASKKCSHLPK	ADAMTS16	1086	Q8TE57
SIYPKSELLEKAAKC	AP4E1	326	Q9UPM8
LCLTKDESKRPKYKE	MAP2K4	346	P45985
RYGKDLLNLSRKKPC	PSTPIP2	51	Q9H939
YKKTESDLLPCKAEE	RGS1	121	Q08116
PAKKKYLCELCLDDV	DAB2IP	226	Q5VWQ8
SPSACYKLFREKQKE	PADI6	506	Q6TGC4
AKKYKSAICRVTLLD	EPB41L1	91	Q9H4G0
KNLYLSCVLKDDKPT	IL1B	181	P01584
KPLRYKRVDKVCISS	MOV10L1	176	Q9BXT6
LKLPRYSCKQVLEEK	HERC2	4766	O95714
RIKLEKLKCDYVSTS	KIAA2026	506	Q5HYC2
LKKDVDCAYLRKSDL	KRT86	211	O43790
KEPLETTCFYRDKKL	LMX1A	66	Q8TE12
KKLRKSLICESLIYT	CSTL1	106	Q9H114
PKCKLARDLKEAYDS	NPRL3	196	Q12980
ECRLAAKLLAKYKSL	GALK2	246	Q01415
CISELNLYKSKDPKE	MPHOSPH9	51	Q99550
YPKGDERKKACLSAL	PI4KA	1751	P42356
VALKKDVDCAYLRKS	KRT87P	41	A6NCN2
FKKPIEEVKSYLRCI	KNTC1	1906	P50748
EGKTFYSKKDRPLCK	PDLIM7	436	Q9NR12
RLEKLGCEPKLEKYL	PLA2G2E	71	Q9NZK7
PDLKRIKKVYCCDLT	CHN2	266	P52757
KYIQKETECLRIAKP	ATM	66	Q13315
ESSDYSVPCKRKKIE	ATM	376	Q13315
KPIESDSKDLCYKDR	FHL5	46	Q5TD97
ICPKDTYSDLKSRDK	DCLRE1C	596	Q96SD1
VTKKGKSYLALRDLC	FRMPD2	331	Q68DX3
CLAARALDKNKIPYK	FEM1A	641	Q9BSK4
KAPELLAKYCDNLLK	CUL2	386	Q13617
KSPELFLCYKRGRDK	DENND4C	81	Q5VZ89
PQLLDCDKVKSSLYK	GALNT17	536	Q6IS24
SALPQYKKKITDRCF	CLPSL2	21	Q6UWE3
SKTDKRLLYCIKADP	ITGA4	881	P13612
RCSKPAKYKKLLFSL	DNAH2	3971	Q9P225
QDDIKILKSLPCYKS	SACS	3401	Q9NZJ4
YRKAKTITQREKDCP	SLFN13	681	Q68D06
RDSPKCYKLTDKTVI	PSMB1	66	P20618
ESCPLYKKLRLSTDT	CASP2	146	P42575
LKKDVDCAYLRKSDL	KRT83	216	P78385
KACAKYKLDRGDPIL	CFAP221	401	Q4G0U5
CLTAPNYRLKSLIKK	TAF9B	121	Q9HBM6
LTAVLPCLAYDDRKK	VAC14	301	Q08AM6
PCLAYDDRKKSIKEV	VAC14	306	Q08AM6
LFLKDYSPKLKRMCE	NPHP3	316	Q7Z494
RAKKFSLYCTKPVTL	TDRD12	121	Q587J7
ACLPYIDFKRLKEKR	INSL6	191	Q9Y581
TCRLEKPAKYDDIKK	GAPDH	246	P04406
TPFRKAKALYACKAE	ARHGAP26	756	Q9UNA1
PEFKIDRASECRKKY	CNKSR2	621	Q8WXI2
QDTFKTCKEYLRPLK	C17orf64	46	Q86WR6
TCKEYLRPLKKFLRK	C17orf64	51	Q86WR6
KDDYSKLCLLLTLPR	WDR47	131	O94967
KALELYKINAKLCDP	UBE3A	71	Q05086
IKEKRETATLKCYPI	TRBV13	41	A0A0A6YYD4
KLCLLSTKYLSRQKP	ZNF268	186	Q14587
TYCSEKKIPFKILLL	TIGD1	286	Q96MW7
LTIKTRSKCDLYGEK	FGD6	151	Q6ZV73
KKLRCEREELPTIYK	ZNF276	421	Q8N554
PEEKLAALCKKYADL	TXLNGY	111	Q9BZA5
YEKTQIKEKDRCPLS	TTC14	566	Q96N46
RDCPNKKAIYASKAV	XDH	1246	P47989
YPQKEILRALKAKCC	RIMKLB	21	Q9ULI2
RTDKKPALCKSYQKL	USP20	181	Q9Y2K6
IELPKKRELCKFYIT	ZC3H4	416	Q9UPT8
LYECSECRKRFSKKP	ZNF84	206	P51523
KRSYIIKCIEDIKRP	USP24	591	Q9UPU5
LKLKKDTSRPYECSE	ZNF212	306	Q9UDV6
IFIIKCSRETEKKYP	PIEZO1	2146	Q92508
PKITADKRYKCSLCE	ZNF354A	206	O60765
SRKKEKCQDSDLYPL	THSD7B	901	Q9C0I4
AKTYLECKEPTLSLK	TRANK1	1761	O15050
TPEEKLAALCKKYAD	TXLNG	151	Q9NUQ3
SYTEGLKKKCADPDL	TTC4	101	O95801
LKKKCADPDLNAVLY	TTC4	106	O95801
CRKLKLPDLKRNDYT	TRPM7	1816	Q96QT4
LLKDLYKCSEKDSIR	UNC45A	481	Q9H3U1
RTDKKPAICKSYLKL	USP33	221	Q8TEY7
VVEPDKDLKYCSAKA	ZC3H7B	706	Q9UGR2
DAVRYLCKKDATKEP	nan	206	Q8N402
LKKDVDCAYLRKSDL	KRT81	211	Q14533
LPDELYFCKKLKTLK	LRRC8C	721	Q8TDW0
KCLTKDYEKRPTVSE	MYO3A	266	Q8NEV4