Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	epoxide hydrolase activity	EPHX4 AKR7A2	4.33e-04	11	57	2	GO:0004301
GeneOntologyMolecularFunction	hydrolase activity, acting on ether bonds	EPHX4 AKR7A2	6.12e-04	13	57	2	GO:0016801
GeneOntologyMolecularFunction	ether hydrolase activity	EPHX4 AKR7A2	6.12e-04	13	57	2	GO:0016803
GeneOntologyBiologicalProcess	type 2 immune response	TRAF3IP2 IL25 HLX ECM1	1.30e-05	55	54	4	GO:0042092
Domain	IL-17_fam	IL17A IL25	1.13e-04	6	52	2	IPR010345
Domain	IL17	IL17A IL25	1.13e-04	6	52	2	PF06083
Domain	VDCC_gsu	CACNG7 CACNG5	2.11e-04	8	52	2	IPR008368
Domain	PLAC	ADAMTS7 ADAMTS17	1.26e-03	19	52	2	IPR010909
Domain	PLAC	ADAMTS7 ADAMTS17	1.26e-03	19	52	2	PS50900
Domain	Homeobox_CS	HOXC5 HLX ZFHX3 NKX2-6	1.78e-03	186	52	4	IPR017970
Domain	ADAM_spacer1	ADAMTS7 ADAMTS17	1.85e-03	23	52	2	IPR010294
Domain	ADAM_spacer1	ADAMTS7 ADAMTS17	1.85e-03	23	52	2	PF05986
Domain	Homeobox_metazoa	HOXC5 HLX NKX2-6	2.02e-03	90	52	3	IPR020479
Domain	Peptidase_M12B_ADAM-TS	ADAMTS7 ADAMTS17	2.02e-03	24	52	2	IPR013273
Domain	Homeobox	HOXC5 HLX ZFHX3 NKX2-6	4.06e-03	234	52	4	PF00046
Domain	HOMEOBOX_1	HOXC5 HLX ZFHX3 NKX2-6	4.18e-03	236	52	4	PS00027
Domain	HOX	HOXC5 HLX ZFHX3 NKX2-6	4.25e-03	237	52	4	SM00389
Domain	Homeobox_dom	HOXC5 HLX ZFHX3 NKX2-6	4.38e-03	239	52	4	IPR001356
Domain	HOMEOBOX_2	HOXC5 HLX ZFHX3 NKX2-6	4.38e-03	239	52	4	PS50071
Domain	Peptidase_M12B_N	ADAMTS7 ADAMTS17	5.27e-03	39	52	2	IPR002870
Domain	Pep_M12B_propep	ADAMTS7 ADAMTS17	5.27e-03	39	52	2	PF01562
Domain	DISINTEGRIN_1	ADAMTS7 ADAMTS17	5.54e-03	40	52	2	PS00427
Domain	PMP22_Claudin	CACNG7 CACNG5	5.54e-03	40	52	2	PF00822
Domain	ADAM_MEPRO	ADAMTS7 ADAMTS17	5.54e-03	40	52	2	PS50215
Domain	DISINTEGRIN_2	ADAMTS7 ADAMTS17	5.54e-03	40	52	2	PS50214
Domain	Reprolysin	ADAMTS7 ADAMTS17	5.54e-03	40	52	2	PF01421
Domain	Peptidase_M12B	ADAMTS7 ADAMTS17	5.54e-03	40	52	2	IPR001590
Domain	CYSTEINE_SWITCH	ADAMTS7 ADAMTS17	5.82e-03	41	52	2	PS00546
Domain	Disintegrin_dom	ADAMTS7 ADAMTS17	5.82e-03	41	52	2	IPR001762
Domain	Pept_M10_metallopeptidase	ADAMTS7 ADAMTS17	6.38e-03	43	52	2	IPR001818
Domain	UBA	LATS2 SQSTM1	6.67e-03	44	52	2	IPR015940
Domain	PMP22/EMP/MP20/Claudin	CACNG7 CACNG5	6.97e-03	45	52	2	IPR004031
Domain	UBA	LATS2 SQSTM1	7.59e-03	47	52	2	PS50030
Domain	-	HOXC5 HLX ZFHX3 NKX2-6	7.90e-03	283	52	4	1.10.10.60
Pathway	WP_IL17_SIGNALING	TRAF3IP2 IL17A IL25	6.62e-05	32	35	3	M39560
Pubmed	Epithelial cell-specific Act1 adaptor mediates interleukin-25-dependent helminth expulsion through expansion of Lin(-)c-Kit(+) innate cell population.	TRAF3IP2 IL17A IL25	4.17e-09	3	57	3	22608496
Pubmed	The critical role of epithelial-derived Act1 in IL-17- and IL-25-mediated pulmonary inflammation.	TRAF3IP2 IL17A IL25	1.67e-08	4	57	3	19155512
Pubmed	IL-17 metabolically reprograms activated fibroblastic reticular cells for proliferation and survival.	TRAF3IP2 ZC3H12A IL17A	4.16e-08	5	57	3	30962593
Pubmed	Astrocyte-restricted ablation of interleukin-17-induced Act1-mediated signaling ameliorates autoimmune encephalomyelitis.	TRAF3IP2 IL17A	2.64e-06	2	57	2	20303295
Pubmed	The novel product of a five-exon stargazin-related gene abolishes Ca(V)2.2 calcium channel expression.	CACNG7 CACNG5	2.64e-06	2	57	2	11927536
Pubmed	IL-17E (IL-25) and IL-17A Differentially Affect the Functions of Human Keratinocytes.	IL17A IL25	2.64e-06	2	57	2	31958433
Pubmed	Phosphorylation-dependent Regnase-1 release from endoplasmic reticulum is critical in IL-17 response.	ZC3H12A IL17A	2.64e-06	2	57	2	31072819
Pubmed	IL-17 drives psoriatic inflammation via distinct, target cell-specific mechanisms.	TRAF3IP2 IL17A	2.64e-06	2	57	2	25092341
Pubmed	T cell-derived Act1 is necessary for IL-25-mediated Th2 responses and allergic airway inflammation.	TRAF3IP2 IL25	2.64e-06	2	57	2	21856933
Pubmed	New transmembrane AMPA receptor regulatory protein isoform, gamma-7, differentially regulates AMPA receptors.	CACNG7 CACNG5	2.64e-06	2	57	2	17475805
Pubmed	IL-17 enhances chemokine gene expression through mRNA stabilization.	TRAF3IP2 IL17A	2.64e-06	2	57	2	17785852
Pubmed	The expression of the receptor for advanced glycation end-products (RAGE) in RA-FLS is induced by IL-17 via Act-1.	TRAF3IP2 IL17A	7.91e-06	3	57	2	21749686
Pubmed	MCPIP1 Endoribonuclease Activity Negatively Regulates Interleukin-17-Mediated Signaling and Inflammation.	ZC3H12A IL17A	7.91e-06	3	57	2	26320658
Pubmed	Zyxin-Siah2-Lats2 axis mediates cooperation between Hippo and TGF-β signalling pathways.	LATS2 ZYX	7.91e-06	3	57	2	27030211
Pubmed	The adaptor protein CIKS/Act1 is essential for IL-25-mediated allergic airway inflammation.	TRAF3IP2 IL25	7.91e-06	3	57	2	19155511
Pubmed	Expression of IL-17A, E, and F and their receptors in non-small-cell lung cancer.	IL17A IL25	7.91e-06	3	57	2	30334403
Pubmed	IL-17A, IL-17E and IL-17F as Potential Biomarkers for the Intensity of Low-Grade Inflammation and the Risk of Cardiovascular Diseases in Obese People.	IL17A IL25	7.91e-06	3	57	2	35277002
Pubmed	Reciprocal expression of IL-25 and IL-17A is important for allergic airways hyperreactivity.	IL17A IL25	7.91e-06	3	57	2	21722219
Pubmed	Macrophages participate in IL-17-mediated inflammation.	TRAF3IP2 IL17A	7.91e-06	3	57	2	22161142
Pubmed	Opposing roles of IL-17A and IL-25 in the regulation of TSLP production in human nasal epithelial cells.	IL17A IL25	7.91e-06	3	57	2	19968632
Pubmed	Sputum cytokine mapping reveals an 'IL-5, IL-17A, IL-25-high' pattern associated with poorly controlled asthma.	IL17A IL25	7.91e-06	3	57	2	23957336
Pubmed	ORF8 contributes to cytokine storm during SARS-CoV-2 infection by activating IL-17 pathway.	TRAF3IP2 IL17A	7.91e-06	3	57	2	33723527
Pubmed	MCPIP1 RNase Is Aberrantly Distributed in Psoriatic Epidermis and Rapidly Induced by IL-17A.	ZC3H12A IL17A	7.91e-06	3	57	2	27180111
Pubmed	Regnase-1 degradation is crucial for IL-33- and IL-25-mediated ILC2 activation.	ZC3H12A IL25	7.91e-06	3	57	2	31990689
Pubmed	MCPIP1/Regnase-1 Restricts IL-17A- and IL-17C-Dependent Skin Inflammation.	ZC3H12A IL17A	1.58e-05	4	57	2	27920272
Pubmed	IL-17-producing ST2+ group 2 innate lymphoid cells play a pathogenic role in lung inflammation.	IL17A IL25	1.58e-05	4	57	2	29625134
Pubmed	Act1 mediates IL-17-induced EAE pathogenesis selectively in NG2+ glial cells.	TRAF3IP2 IL17A	1.58e-05	4	57	2	23995070
Pubmed	Extracellular matrix protein 1, a direct targeting molecule of parathyroid hormone-related peptide, negatively regulates chondrogenesis and endochondral ossification via associating with progranulin growth factor.	ADAMTS7 ECM1	1.58e-05	4	57	2	27075243
Pubmed	RECK suppresses interleukin-17/TRAF3IP2-mediated MMP-13 activation and human aortic smooth muscle cell migration and proliferation.	TRAF3IP2 IL17A	1.58e-05	4	57	2	31074012
Pubmed	A multi-method assessment of bone maintenance and loss in an Imperial Roman population: Implications for future studies of age-related bone loss in the past.	TRAF3IP2 IL17A	1.58e-05	4	57	2	28581022
Pubmed	Commensal-dependent expression of IL-25 regulates the IL-23-IL-17 axis in the intestine.	IL17A IL25	1.58e-05	4	57	2	18762568
Pubmed	Expression of IL-17A, E, and F and their receptors in human prostatic cancer: Comparison with benign prostatic hyperplasia.	IL17A IL25	1.58e-05	4	57	2	26356122
Pubmed	Diabetes induces IL-17A-Act1-FADD-dependent retinal endothelial cell death and capillary degeneration.	TRAF3IP2 IL17A	1.58e-05	4	57	2	31239234
Pubmed	Interleukin-17B Antagonizes Interleukin-25-Mediated Mucosal Inflammation.	TRAF3IP2 IL25	2.63e-05	5	57	2	25888259
Pubmed	Interleukin-17 cytokines are critical in development of fatal lupus glomerulonephritis.	TRAF3IP2 IL17A	2.63e-05	5	57	2	23123062
Pubmed	IL-17 activates the canonical NF-kappaB signaling pathway in autoimmune B cells of BXD2 mice to upregulate the expression of regulators of G-protein signaling 16.	TRAF3IP2 IL17A	2.63e-05	5	57	2	20139273
Pubmed	The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation.	UBA1 SQSTM1	2.63e-05	5	57	2	22797925
Pubmed	Negative regulation of IL-17-mediated signaling and inflammation by the ubiquitin-specific protease USP25.	TRAF3IP2 IL17A	2.63e-05	5	57	2	23042150
Pubmed	Requirement for both JAK-mediated PI3K signaling and ACT1/TRAF6/TAK1-dependent NF-kappaB activation by IL-17A in enhancing cytokine expression in human airway epithelial cells.	TRAF3IP2 IL17A	2.63e-05	5	57	2	17982039
Pubmed	The H2.0-like homeobox transcription factor modulates yolk sac vascular remodeling in mouse embryos.	GJA5 HLX	2.63e-05	5	57	2	24764455
Pubmed	Oral epithelial cells orchestrate innate type 17 responses to Candida albicans through the virulence factor candidalysin.	TRAF3IP2 IL17A	3.94e-05	6	57	2	29101209
Pubmed	Act1, a U-box E3 ubiquitin ligase for IL-17 signaling.	TRAF3IP2 IL17A	3.94e-05	6	57	2	19825828
Pubmed	IL-17 induced NOTCH1 activation in oligodendrocyte progenitor cells enhances proliferation and inflammatory gene expression.	TRAF3IP2 IL17A	3.94e-05	6	57	2	28561022
Pubmed	Cutting Edge: IL-25 Targets Dendritic Cells To Attract IL-9-Producing T Cells in Acute Allergic Lung Inflammation.	TRAF3IP2 IL25	3.94e-05	6	57	2	26371249
Pubmed	Cutting edge: TNF receptor-associated factor 4 restricts IL-17-mediated pathology and signaling processes.	TRAF3IP2 IL17A	3.94e-05	6	57	2	22649194
Pubmed	IL-17RC is required for immune signaling via an extended SEF/IL-17R signaling domain in the cytoplasmic tail.	TRAF3IP2 IL17A	3.94e-05	6	57	2	20554964
Pubmed	Ubiquitylation of autophagy receptor Optineurin by HACE1 activates selective autophagy for tumor suppression.	UBA1 SQSTM1	3.94e-05	6	57	2	25026213
Pubmed	Epithelial cell-derived IL-25, but not Th17 cell-derived IL-17 or IL-17F, is crucial for murine asthma.	IL17A IL25	5.51e-05	7	57	2	22942422
Pubmed	Calcium channel gamma subunits provide insights into the evolution of this gene family.	CACNG7 CACNG5	5.51e-05	7	57	2	11738816
Pubmed	Screening large numbers of expression patterns of transcription factors in late stages of the mouse thymus.	FOXJ2 HOXC5 ZFHX3 NKX2-6 ZYX	7.23e-05	263	57	5	20932939
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	ITPRIPL2 LATS2 ADAMTS7 NFX1 SAC3D1 ZNF579 FAAP100 REPIN1 ADCY7	7.29e-05	1105	57	9	35748872
Pubmed	Calcium channel gamma subunits: a functionally diverse protein family.	CACNG7 CACNG5	7.34e-05	8	57	2	17652770
Pubmed	Essential role of Hand2 in interventricular septum formation and trabeculation during cardiac development.	GJA5 HAND1	7.34e-05	8	57	2	16530167
Pubmed	Interleukin-23-Independent IL-17 Production Regulates Intestinal Epithelial Permeability.	TRAF3IP2 IL17A	7.34e-05	8	57	2	26431948
Pubmed	The induction and function of the anti-inflammatory fate of TH17 cells.	TRIM33 IL17A	7.34e-05	8	57	2	32620760
Pubmed	IL-17C/IL-17RE Augments T Cell Function in Autoimmune Hepatitis.	TRAF3IP2 IL17A	9.43e-05	9	57	2	27956525
Pubmed	A Conserved LIR Motif in Connexins Mediates Ubiquitin-Independent Binding to LC3/GABARAP Proteins.	GJA5 SQSTM1	9.43e-05	9	57	2	32272685
Pubmed	A cluster of three novel Ca2+ channel gamma subunit genes on chromosome 19q13.4: evolution and expression profile of the gamma subunit gene family.	CACNG7 CACNG5	9.43e-05	9	57	2	11170751
Pubmed	Treatment with IL-17 prolongs the half-life of chemokine CXCL1 mRNA via the adaptor TRAF5 and the splicing-regulatory factor SF2 (ASF).	TRAF3IP2 IL17A	9.43e-05	9	57	2	21822258
Pubmed	An ACT1 mutation selectively abolishes interleukin-17 responses in humans with chronic mucocutaneous candidiasis.	TRAF3IP2 IL17A	1.18e-04	10	57	2	24120361
Pubmed	Isolation of arterial-specific genes by subtractive hybridization reveals molecular heterogeneity among arterial endothelial cells.	GJA5 DEPP1	1.18e-04	10	57	2	15977181
Pubmed	The Hand1 and Hand2 transcription factors regulate expansion of the embryonic cardiac ventricles in a gene dosage-dependent manner.	GJA5 HAND1	1.44e-04	11	57	2	15576406
Pubmed	The Rho guanine nucleotide exchange factor AKAP13 (BRX) is essential for cardiac development in mice.	GJA5 HAND1	1.44e-04	11	57	2	20139090
Pubmed	Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.	TRIM33 HOXC5 ITPRIPL2 FAT3 NKX2-6 ZNF579 FAAP100 REPIN1 PCK2	1.50e-04	1215	57	9	15146197
Pubmed	A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.	FOXJ2 HOXC5 SQSTM1 NFX1 HAND1 ZFHX3 ZYX	1.55e-04	709	57	7	22988430
Pubmed	Hesr1 and Hesr2 regulate atrioventricular boundary formation in the developing heart through the repression of Tbx2.	GJA5 HAND1	1.72e-04	12	57	2	17259303
Pubmed	Hand1 regulates cardiomyocyte proliferation versus differentiation in the developing heart.	GJA5 HAND1	1.72e-04	12	57	2	17050624
Pubmed	Insights on ADAMTS proteases and ADAMTS-like proteins from mammalian genetics.	ADAMTS7 ADAMTS17	1.72e-04	12	57	2	25770910
Pubmed	Expression of Slit and Robo genes in the developing mouse heart.	ROBO1 HAND1	2.03e-04	13	57	2	20941780
Pubmed	Identification of downstream genetic pathways of Tbx1 in the second heart field.	HAND1 NKX2-6	2.03e-04	13	57	2	18328475
Pubmed	Dysregulated Lung Commensal Bacteria Drive Interleukin-17B Production to Promote Pulmonary Fibrosis through Their Outer Membrane Vesicles.	IL17A IL25	2.03e-04	13	57	2	30824326
Pubmed	Slit-roundabout signaling regulates the development of the cardiac systemic venous return and pericardium.	GJA5 ROBO1	2.73e-04	15	57	2	23255421
Pubmed	Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeability.	GJA5 ROBO1	2.73e-04	15	57	2	18345009
Pubmed	Variation in a Left Ventricle-Specific Hand1 Enhancer Impairs GATA Transcription Factor Binding and Disrupts Conduction System Development and Function.	GJA5 HAND1	2.73e-04	15	57	2	31366290
Pubmed	Hand factor ablation causes defective left ventricular chamber development and compromised adult cardiac function.	GJA5 HAND1	2.73e-04	15	57	2	28732025
Pubmed	Endothelin receptor type A expression defines a distinct cardiac subdomain within the heart field and is later implicated in chamber myocardium formation.	GJA5 HAND1	3.12e-04	16	57	2	20929948
Pubmed	Tbx2 is essential for patterning the atrioventricular canal and for morphogenesis of the outflow tract during heart development.	GJA5 HAND1	3.53e-04	17	57	2	15459098
Pubmed	A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease.	GJA5 HAND1	3.53e-04	17	57	2	11572777
Pubmed	Compartmentalized metabolism supports midgestation mammalian development.	GJA5 HAND1	3.53e-04	17	57	2	35388219
Pubmed	Chromatin remodelling complex dosage modulates transcription factor function in heart development.	GJA5 HAND1	3.53e-04	17	57	2	21304516
Pubmed	Neuregulin 1 sustains the gene regulatory network in both trabecular and nontrabecular myocardium.	GJA5 HAND1	4.43e-04	19	57	2	20651287
Pubmed	TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity.	SQSTM1 TRIM65	4.43e-04	19	57	2	26347139
Pubmed	Hand2 loss-of-function in Hand1-expressing cells reveals distinct roles in epicardial and coronary vessel development.	GJA5 HAND1	4.92e-04	20	57	2	21350214
Pubmed	The mouse PcG gene eed is required for Hox gene repression and extraembryonic development.	HOXC5 HAND1	4.92e-04	20	57	2	12370779
Pubmed	Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity.	TRIM33 UBA1 TRIM65	5.19e-04	95	57	3	29643511
Pubmed	HAND1 loss-of-function within the embryonic myocardium reveals survivable congenital cardiac defects and adult heart failure.	GJA5 HAND1	5.97e-04	22	57	2	31286141
Pubmed	Nrf2 signalling and autophagy are involved in diabetes mellitus-induced defects in the development of mouse placenta.	SQSTM1 HAND1	5.97e-04	22	57	2	27383629
Pubmed	Expanding the Interactome of TES by Exploiting TES Modules with Different Subcellular Localizations.	SQSTM1 TRIM65 ZYX PCK2	6.06e-04	235	57	4	28378594
Pubmed	Failure of extra-embryonic progenitor maintenance in the absence of dosage compensation.	UBA1 HAND1	6.53e-04	23	57	2	22573614
Pubmed	A census of human transcription factors: function, expression and evolution.	FOXJ2 HOXC5 NFX1 HLX HAND1 ZFHX3 NKX2-6	6.86e-04	908	57	7	19274049
Pubmed	WD40 repeat and FYVE domain containing 3 is essential for cardiac development.	SQSTM1 HAND1	7.73e-04	25	57	2	30428088
Pubmed	Myocardial Tbx20 regulates early atrioventricular canal formation and endocardial epithelial-mesenchymal transition via Bmp2.	GJA5 HAND1	9.02e-04	27	57	2	21983003
Pubmed	Tbx20 is essential for cardiac chamber differentiation and repression of Tbx2.	GJA5 HAND1	9.71e-04	28	57	2	15901664
Pubmed	Specification of jaw identity by the Hand2 transcription factor.	HAND1 ZFHX3	9.71e-04	28	57	2	27329940
Pubmed	Nrg1 Regulates Cardiomyocyte Migration and Cell Cycle in Ventricular Development.	GJA5 HAND1	9.71e-04	28	57	2	37846569
Pubmed	Murine T-box transcription factor Tbx20 acts as a repressor during heart development, and is essential for adult heart integrity, function and adaptation.	GJA5 HAND1	1.19e-03	31	57	2	15843414
Pubmed	The autophagy-inducing kinases, ULK1 and ULK2, regulate axon guidance in the developing mouse forebrain via a noncanonical pathway.	SQSTM1 ROBO1	1.19e-03	31	57	2	29099309
Pubmed	Splicing Regulator p54nrb /Non-POU Domain-Containing Octamer-Binding Protein Enhances Carcinogenesis Through Oncogenic Isoform Switch of MYC Box-Dependent Interacting Protein 1 in Hepatocellular Carcinoma.	REPIN1 PCK2	1.27e-03	32	57	2	31815296
Pubmed	NOTCH maintains developmental cardiac gene network through WNT5A.	GJA5 HAND1	1.27e-03	32	57	2	30347193
Pubmed	Semaphorin 3E/PlexinD1 signaling is required for cardiac ventricular compaction.	GJA5 ADAMTS7	1.27e-03	32	57	2	31434798
GeneFamily	ADAM metallopeptidases with thrombospondin type 1 motif	ADAMTS7 ADAMTS17	7.19e-04	19	38	2	50
GeneFamily	Calcium voltage-gated channel subunits	CACNG7 CACNG5	1.35e-03	26	38	2	253
GeneFamily	Endogenous ligands\|Interleukins	IL17A IL25	3.68e-03	43	38	2	601
Coexpression	THAKAR_PBMC_INACTIVATED_INFLUENZA_AGE_21_30YO_RESPONDERS_28DY_DN	FOXJ2 CIDEB ZC3H12A PPP1R3E ZFHX3 FAAP100 SLC4A5 REPIN1 ZYX BTN2A1 ADCY7	3.38e-06	905	57	11	M40865
Coexpression	THAKAR_PBMC_INACTIVATED_INFLUENZA_AGE_21_30YO_RESPONDERS_7DY_DN	FOXJ2 CIDEB ZC3H12A PPP1R3E ZFHX3 REPIN1 ZYX BTN2A1 ADCY7	8.55e-06	634	57	9	M40866
CoexpressionAtlas	dev lower uro neuro_e14.5_PelvicGanglion_Sox10_k-means-cluster#3_top-relative-expression-ranked_200	GJA5 CACNG7 FAT3 ADAMTS17	2.36e-05	67	53	4	gudmap_dev lower uro neuro_e14.5_PelvicGanglion_Sox10_k3_200
ToppCell	COPD-Stromal-Myofibroblast\|Stromal / Disease state, Lineage and Cell class	FAT3 DEPP1 ADAMTS17 ROBO1 ZYX	4.70e-06	192	57	5	62904f94dfce430456f05066522cbf9bd29f4d7e
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DENND2A FAT3 ADAMTS17 KIAA1755 ROBO1	4.94e-06	194	57	5	89b706af2b25991fc2707eb24f49ba6ff3ae01f7
ToppCell	TCGA-Mesothelium-Primary_Tumor-Mesothelioma-Biphasic-3\|TCGA-Mesothelium / Sample_Type by Project: Shred V9	HOXC5 ADAMTS17 NKX2-6 TMEM88B	2.13e-05	127	57	4	df2854bcb2708ddc13b3ca48c03887380e827790
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_atypical\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	GJA5 UBA1 ADAMTS7 ROBO1	3.88e-05	148	57	4	b7b5521162effc1024e7c399f690cd86d0b2f750
ToppCell	TCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Rectal_Adenocarcinoma-3\|TCGA-Colorectal / Sample_Type by Project: Shred V9	ADAMTS7 SAC3D1 ZNF579 FAAP100	4.76e-05	156	57	4	b464871ad7c8ce0d58013a27996639eac1e526d8
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Mesenchymal-myocytic-SMC_(PART1/CAPN3+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HOXC5 KLF14 HAND1 ZYX	5.65e-05	163	57	4	e526104a3a574ee860078ce7c049e7fec9443f37
ToppCell	Entopeduncular-Macroglia-OLIGODENDROCYTE-O1-Trf-Oligodendrocyte.Trf.Serpinb1a_(Serpinb1a)\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	CCDC27 CCDC78 SLC4A5	6.27e-05	60	57	3	48adafeec1810bce5f118fa63d4a8ee7ab9ca0f7
ToppCell	Entopeduncular-Macroglia-OLIGODENDROCYTE-O1-Trf-Oligodendrocyte.Trf.Serpinb1a_(Serpinb1a)-\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	CCDC27 CCDC78 SLC4A5	6.27e-05	60	57	3	a83afb89dbfc2e1cdfce57320d89c980bd8fb820
ToppCell	P15-Mesenchymal-mesenchymal_fibroblast-mesenchymal_progenitor_cell\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	CIDEB ADAMTS7 FAT3 ZYX	6.65e-05	170	57	4	ba4ba66b624089ed50a9083176386c7941b4c7a3
ToppCell	droplet-Fat-Bat-18m-Endothelial-nan\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GJA5 DEPP1 TRIM65 FAAP100	8.12e-05	179	57	4	9863ab3ceb160a4b1d9790033a4ac48845863d65
ToppCell	droplet-Fat-Bat-18m-Endothelial\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GJA5 DEPP1 TRIM65 FAAP100	8.12e-05	179	57	4	dfe110add7228cd834b35916cbcc849769a01bb9
ToppCell	droplet-Fat-Bat-18m-Endothelial-endothelial_cell\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GJA5 DEPP1 TRIM65 FAAP100	8.12e-05	179	57	4	e6224864eb76a2e9c1fc0c61513d9e936bb5c72c
ToppCell	droplet-Kidney-KIDNEY-1m-Epithelial-Pecam____kidney_capillary_endothelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DENND2A GJA5 ADAMTS7 ROBO1	9.03e-05	184	57	4	1c857126c0ea0671f0d60b048efca288d348d653
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro2_(5)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	ADAMTS17 KIAA1755 ROBO1 ZFHX3	9.22e-05	185	57	4	9f19f04fc4d97dfc2dd78cde77b515f1cb5d51ec
ToppCell	Control-Fibroblasts-Alveolar_FB\|Control / group, cell type (main and fine annotations)	DENND2A FAT3 ADAMTS17 ROBO1	9.61e-05	187	57	4	92d468dde81125d51daf7abd4703741abe1ab91c
ToppCell	droplet-Kidney-nan-3m-Epithelial-Pecam____Kidney_cortex_artery_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GJA5 DEPP1 CACNG5 EPHX4	9.81e-05	188	57	4	ec0e241de2c8310b4417b9d4e2420d7a1662f1c0
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DENND2A ADAMTS17 KIAA1755 ROBO1	1.02e-04	190	57	4	45df8fee00f8949937863159d7aa042e72748d9b
ToppCell	RV-01._Fibroblast_I\|World / Chamber and Cluster_Paper	DENND2A ADAMTS17 ROBO1 ZFHX3	1.04e-04	191	57	4	70c067c54084bfb02c29bab085f4defd477194fb
ToppCell	nucseq-Mesenchymal-Fibroblastic-Fibroblastic_2-AF1\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	DENND2A FAT3 ADAMTS17 ROBO1	1.04e-04	191	57	4	6688cee34beee4f151ac17fccbc9c26a9aad72e1
ToppCell	nucseq-Mesenchymal-Fibroblastic-Fibroblastic_2\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	DENND2A FAT3 ADAMTS17 ROBO1	1.06e-04	192	57	4	99ce9e3c4c50cf64ebb62145f2b5420efa0db309
ToppCell	RV-01._Fibroblast_I\|RV / Chamber and Cluster_Paper	DENND2A ADAMTS17 ROBO1 ZFHX3	1.06e-04	192	57	4	356160b113c3305a61ceeaff33ce3c9da0be2878
ToppCell	LPS_only-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DENND2A ADAMTS17 KIAA1755 ROBO1	1.06e-04	192	57	4	df1545670370fb1010c567cd059c2783eab315f7
ToppCell	PND28-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_mature\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	GJA5 FAT3 ADAMTS17 ZYX	1.09e-04	193	57	4	4c74a3f69b2cbdf139e7e66b44bd86869ac34dc0
ToppCell	Mesenchymal-matrix_fibroblast_1_cell\|World / Lineage, Cell type, age group and donor	DENND2A GJA5 FAT3 ROBO1	1.09e-04	193	57	4	acad568621ed677031797b8c2e34dafea798d681
ToppCell	PND28-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	GJA5 FAT3 ADAMTS17 ZYX	1.09e-04	193	57	4	ff8ceeb3cfd1bef7239df490c19d181091750833
ToppCell	COVID-19-Fibroblasts-Alveolar_FB\|COVID-19 / group, cell type (main and fine annotations)	DENND2A FAT3 ADAMTS17 ROBO1	1.13e-04	195	57	4	603050beeb33c331d4b2e3fa46cae3f3e0e4bdc7
ToppCell	367C-Fibroblasts-Fibroblast-C_(Myofibroblast)-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	GJA5 FAT3 DEPP1 ZYX	1.15e-04	196	57	4	6730743cf088c419ccc2d28765769fc09d3ba6a7
ToppCell	367C-Fibroblasts-Fibroblast-C_(Myofibroblast)\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	GJA5 FAT3 DEPP1 ZYX	1.15e-04	196	57	4	21dab89f3699037138a9c7a0e4dc98739a9fad9c
ToppCell	nucseq-Mesenchymal-Fibroblastic\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	DENND2A FAT3 ADAMTS17 ROBO1	1.15e-04	196	57	4	7d8505dac15fa59935ccf592afc54b04c4c6554f
ToppCell	proximal-mesenchymal-Alveolar_Fibroblast\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	GJA5 FAT3 ECM1 ZYX	1.22e-04	199	57	4	7f4840ae6a888380feca722543e5e52783f3e35d
ToppCell	proximal-3-mesenchymal-Alveolar_Fibroblast\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	GJA5 FAT3 ECM1 ZYX	1.22e-04	199	57	4	301d02bbb37e6f1d24b6e865bc3fe3e91260eb30
ToppCell	proximal-mesenchymal-Alveolar_Fibroblast-3\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	GJA5 FAT3 ECM1 ZYX	1.22e-04	199	57	4	9a16e519fb0651a7c4d8e05b931df4fb3b0eb3d1
ToppCell	LPS_anti-TNF-Hematopoietic_Erythro-Megakary-Erythro-Mega-Platelets\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	DENND2A TRIM65 ECM1 ZYX	1.24e-04	200	57	4	e4be88bcef2738915f711b32c95e9c613e7edf96
ToppCell	Parenchymal-NucSeq-Stromal-Fibroblastic-Fibro_alveolar\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DENND2A FAT3 ADAMTS17 ROBO1	1.24e-04	200	57	4	34f52003988ce6329d8deeee1ab875fa77e01e9d
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW23-Neuronal-Intermediate\|GW23 / Sample Type, Dataset, Time_group, and Cell type.	TRIM33 DEPP1 TRIM65 ST3GAL2	1.24e-04	200	57	4	fe772d98c461c973dfc082e1fc50117c27ced804
Disease	smoking behavior, BMI-adjusted waist circumference	HOXC5 ADAMTS17 HLX NKX2-6	7.50e-05	122	54	4	EFO_0004318, EFO_0007789
Disease	familial atrial fibrillation (is_implicated_in)	GJA5 NKX2-6	2.95e-04	14	54	2	DOID:0050650 (is_implicated_in)
Disease	Tetralogy of Fallot	GJA5 NKX2-6	3.88e-04	16	54	2	C0039685
Disease	ATRIAL FIBRILLATION, FAMILIAL, 1 (disorder)	GJA5 NKX2-6	7.42e-04	22	54	2	C1843687
Disease	caudate nucleus volume	FAT3 ZFHX3	1.38e-03	30	54	2	EFO_0004830
Disease	cuneus cortex volume measurement	IL17A ADAMTS17	1.48e-03	31	54	2	EFO_0010301
Disease	atrial fibrillation (is_marker_for)	GJA5 ROBO1	1.57e-03	32	54	2	DOID:0060224 (is_marker_for)
Disease	atopic dermatitis (is_marker_for)	IL17A IL25	1.88e-03	35	54	2	DOID:3310 (is_marker_for)
Disease	response to glucocorticoid, osteonecrosis	KLF14 ZFHX3	2.33e-03	39	54	2	EFO_0004259, GO_0051384
Disease	BMI-adjusted waist-hip ratio, sex interaction measurement	KLF14 NKX2-6	2.83e-03	43	54	2	EFO_0007788, EFO_0008343
Disease	psoriasis (is_marker_for)	IL17A IL25	2.96e-03	44	54	2	DOID:8893 (is_marker_for)

Protein segments in the cluster

Peptide	Gene	Start	Entry
RAAVHCALRSPPPEA	AKR7A2	11	O43488
PHRPAQACRKGRPAV	DEPP1	66	Q9NTK1
VARPAEPAPFNKRHC	AJM1	36	C9J069
RLAPIPRARHDFACA	ADCY7	586	P51828
ASRPEPQVRRCNLHP	ADAMTS17	846	Q8TE56
DTRDLRPLRPFHCQP	ADAMTS7	1491	Q9UKP4
RVFPTHPDCPQFSTR	CCDC27	126	Q2M243
RERSCPAASPHPRVR	NKX2-6	21	A6NCS4
NPRAHPDRPACSAAA	HOXC5	66	Q00444
TRRPFVPQSCLPHEA	MKKS	516	Q9NPJ1
PHASFQAAARSPLRP	HLX	81	Q14774
LEAPPRAHVAFRPDC	LATS2	386	Q9NRM7
RAHVAFRPDCPVPSR	LATS2	391	Q9NRM7
FRRPAREHPPACLSD	EPHX4	51	Q8IUS5
SCPEAPAAHSARPER	KIAA1755	1056	Q5JYT7
PCAHPNSRFCAPARQ	PCK2	416	Q16822
APLPGRPDAFHRCIF	PDCD2	66	Q16342
NRIGRRNYSSPPPCH	NFX1	41	Q12986
PAPLRVHCPSFRADS	LRRC14B	181	A6NHZ5
PFLFGPASRCHQERP	HAND1	26	O96004
THRPPAPARIADSCA	FOXJ2	486	Q9P0K8
VLRREPPHCPNSFRL	IL17A	121	Q16552
QCLRFPGLAPPHTRA	FAAP100	651	Q0VG06
RPHPGFYRPRLSNCS	CACNG5	211	Q9UF02
PDPGRPAAYRRAHVC	DSCR9	41	P59020
PCPSARARPRHKSLN	DENND2A	31	Q9ULE3
RRSPCPHPVNCYVSR	GJA5	186	P36382
LSPDCRRRPQFHPSQ	FAT3	4446	Q8TDW7
CAVPVESDPRHPRAA	CCDC78	111	A2IDD5
RPHPAFYRPRLSDCS	CACNG7	211	P62955
RRCPFRHLGESVPDN	BTN2A1	351	Q7KYR7
RSVTPAAKRHQCPFP	KLF14	186	Q8TD94
PLEPARPNRHPESCR	IL25	61	Q9H293
HSFRIRVAACPQAPG	IGFN1	1031	Q86VF2
HPPSPTRDECFARRA	ECM1	386	Q16610
RPASRAFPQHCRPRD	SAC3D1	21	A6NKF1
AFPQHCRPRDAERPP	SAC3D1	26	A6NKF1
CRHAVRQRFLPGSPR	ITPRIPL2	66	Q3MIP1
RCDPVPAANGAIRFH	TRIM33	446	Q9UPN9
QRDALRHFAPCQPRA	PPP1R3E	121	Q9H7J1
RHFAPCQPRARGLQE	PPP1R3E	126	Q9H7J1
RARCPQSAHPAPTRG	PRR34	41	Q9NV39
PGENPYRFRDPHQCR	ST3GAL2	136	Q16842
RRDHRPPCAQEAPRN	SQSTM1	106	Q13501
PCPECGRRFRHAPFL	REPIN1	86	Q9BWE0
APPPQRPFRVCDHKR	CIDEB	31	Q9UHD4
PAQRDCSFPGLPRHQ	TRAF3IP2	336	O43734
CSSAPPRPTRRFHTV	C12orf42	331	Q96LP6
RHNKSCARNRCPRPP	SWI5	11	Q1ZZU3
FHPERPSCPQRSVAD	ZC3H12A	321	Q5D1E8
PSHRECFLPSVARTP	RP1L1	11	Q8IWN7
TNHRRRFPDQKECPP	SLC4A5	16	Q9BY07
AAGRRHFHASQCPRP	ROBO1	1426	Q9Y6N7
RVHPAPGPRCRALFS	TMEM88B	86	A6NKF7
LHQFCAQHGRPPRPR	UBA1	336	P22314
ADRPPANSHRRVCPF	ZNF843	131	Q8N446
RCHQPLARAQPAVRA	ZYX	386	Q15942
PAARCPRHGRPLELF	TRIM65	91	Q6PJ69
HPCPRCPRRFSRAYS	ZNF579	441	Q8NAF0
FRAVGPAQAHRRCPF	ZFHX3	2701	Q15911