Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	structural constituent of skin epidermis	SPRR2A SPRR2B SPRR2E SPRR2F	8.81e-08	43	20	4	GO:0030280
GeneOntologyMolecularFunction	structural molecule activity	SPRR2A SPRR2B SPRR2E SPRR2F	1.08e-02	891	20	4	GO:0005198
GeneOntologyMolecularFunction	lipid binding	SPRR2A SPRR2B SPRR2E SPRR2F	1.53e-02	988	20	4	GO:0008289
GeneOntologyBiologicalProcess	keratinization	LCE1C LCE3D LCE1B LCE1E LCE1D SPRR2A SPRR2B LCE1A SPRR2D LCE2D SPRR2E LCE2C SPRR2F LCE3B SPRR2G LCE1F LCE2A LCE4A LCE3E LCE3C LCE5A LCE2B	3.13e-54	87	22	22	GO:0031424
GeneOntologyBiologicalProcess	keratinocyte differentiation	LCE1C LCE3D LCE1B LCE1E LCE1D SPRR2A SPRR2B LCE1A SPRR2D LCE2D SPRR2E LCE2C SPRR2F LCE3B SPRR2G LCE1F LCE2A LCE4A LCE3E LCE3C LCE5A LCE2B	4.15e-46	189	22	22	GO:0030216
GeneOntologyBiologicalProcess	epidermal cell differentiation	LCE1C LCE3D LCE1B LCE1E LCE1D SPRR2A SPRR2B LCE1A SPRR2D LCE2D SPRR2E LCE2C SPRR2F LCE3B SPRR2G LCE1F LCE2A LCE4A LCE3E LCE3C LCE5A LCE2B	4.99e-42	284	22	22	GO:0009913
GeneOntologyBiologicalProcess	skin development	LCE1C LCE3D LCE1B LCE1E LCE1D SPRR2A SPRR2B LCE1A SPRR2D LCE2D SPRR2E LCE2C SPRR2F LCE3B SPRR2G LCE1F LCE2A LCE4A LCE3E LCE3C LCE5A LCE2B	2.46e-39	373	22	22	GO:0043588
GeneOntologyBiologicalProcess	epidermis development	LCE1C LCE3D LCE1B LCE1E LCE1D SPRR2A SPRR2B LCE1A SPRR2D LCE2D SPRR2E LCE2C SPRR2F LCE3B SPRR2G LCE1F LCE2A LCE4A LCE3E LCE3C LCE5A LCE2B	2.94e-37	461	22	22	GO:0008544
GeneOntologyBiologicalProcess	epithelial cell differentiation	LCE1C LCE3D LCE1B LCE1E LCE1D SPRR2A SPRR2B LCE1A SPRR2D LCE2D SPRR2E LCE2C SPRR2F LCE3B SPRR2G LCE1F LCE2A LCE4A LCE3E LCE3C LCE5A LCE2B	4.37e-31	870	22	22	GO:0030855
GeneOntologyBiologicalProcess	epithelium development	LCE1C LCE3D LCE1B LCE1E LCE1D SPRR2A SPRR2B LCE1A SPRR2D LCE2D SPRR2E LCE2C SPRR2F LCE3B SPRR2G LCE1F LCE2A LCE4A LCE3E LCE3C LCE5A LCE2B	4.94e-26	1469	22	22	GO:0060429
GeneOntologyBiologicalProcess	response to estradiol	SPRR2A SPRR2B SPRR2E SPRR2F	9.49e-06	128	22	4	GO:0032355
GeneOntologyBiologicalProcess	defense response to Gram-positive bacterium	SPRR2A LCE3B LCE3C	5.25e-04	150	22	3	GO:0050830
GeneOntologyBiologicalProcess	defense response to Gram-negative bacterium	LCE3B LCE3C	7.07e-03	119	22	2	GO:0050829
GeneOntologyBiologicalProcess	disruption of cell in another organism	LCE3B LCE3C	8.26e-03	129	22	2	GO:0141061
GeneOntologyBiologicalProcess	killing of cells of another organism	LCE3B LCE3C	8.26e-03	129	22	2	GO:0031640
GeneOntologyBiologicalProcess	disruption of anatomical structure in another organism	LCE3B LCE3C	8.63e-03	132	22	2	GO:0141060
GeneOntologyBiologicalProcess	defense response to bacterium	SPRR2A LCE3B LCE3C	8.77e-03	405	22	3	GO:0042742
GeneOntologyCellularComponent	cornified envelope	LCE1D SPRR2A SPRR2B SPRR2D SPRR2E SPRR2F SPRR2G	5.91e-14	69	17	7	GO:0001533
GeneOntologyCellularComponent	secretory granule	SPRR2A SPRR2B SPRR2E SPRR2F	7.89e-03	1014	17	4	GO:0030141
GeneOntologyCellularComponent	secretory vesicle	SPRR2A SPRR2B SPRR2E SPRR2F	1.60e-02	1246	17	4	GO:0099503
MousePheno	increased total body fat amount	LCE1C LCE1B LCE1E LCE1D LCE1A LCE2D LCE2C LCE5A	6.72e-13	424	8	8	MP:0010024
MousePheno	decreased bone mineral content	LCE1C LCE1B LCE1E LCE1D LCE1A LCE2D LCE2C LCE5A	1.41e-12	465	8	8	MP:0010124
MousePheno	abnormal bone mineral content	LCE1C LCE1B LCE1E LCE1D LCE1A LCE2D LCE2C LCE5A	4.41e-11	713	8	8	MP:0010122
MousePheno	abnormal adipose tissue amount	LCE1C LCE1B LCE1E LCE1D LCE1A LCE2D LCE2C LCE5A	1.21e-09	1077	8	8	MP:0005452
MousePheno	abnormal adipose tissue morphology	LCE1C LCE1B LCE1E LCE1D LCE1A LCE2D LCE2C LCE5A	7.92e-09	1361	8	8	MP:0000003
MousePheno	abnormal bone structure	LCE1C LCE1B LCE1E LCE1D LCE1A LCE2D LCE2C LCE5A	8.81e-09	1379	8	8	MP:0003795
MousePheno	adipose tissue phenotype	LCE1C LCE1B LCE1E LCE1D LCE1A LCE2D LCE2C LCE5A	9.01e-09	1383	8	8	MP:0005375
Domain	SPRR/LCE	LCE1C LCE1B LCE1E LCE1D SPRR2A SPRR2B LCE1A SPRR2D LCE2D SPRR2E LCE2C SPRR2F LCE3B LCE1F LCE2A LCE4A LCE3E LCE3C LCE5A LCE2B	6.61e-59	28	22	20	IPR026075
Domain	LCE	LCE1C LCE3D LCE1B LCE1E LCE1D LCE1A LCE2D LCE2C LCE3B LCE1F LCE2A LCE4A LCE3E LCE3C LCE5A LCE2B	1.22e-49	17	22	16	IPR028205
Domain	LCE	LCE1C LCE3D LCE1B LCE1E LCE1D LCE1A LCE2D LCE2C LCE3B LCE1F LCE2A LCE4A LCE3E LCE3C LCE5A LCE2B	1.22e-49	17	22	16	PF14672
Domain	SPRR2	SPRR2A SPRR2B SPRR2D SPRR2E SPRR2F SPRR2G	1.27e-18	6	22	6	PF14820
Domain	SPRR2	SPRR2A SPRR2B SPRR2D SPRR2E SPRR2F SPRR2G	1.27e-18	6	22	6	IPR029142
Pathway	REACTOME_FORMATION_OF_THE_CORNIFIED_ENVELOPE	LCE1C LCE3D LCE1B LCE1E LCE1D SPRR2A SPRR2B LCE1A SPRR2D LCE2D SPRR2E LCE2C SPRR2F LCE3B SPRR2G LCE1F LCE2A LCE4A LCE3E LCE3C LCE5A LCE2B	2.16e-46	129	22	22	M27649
Pathway	REACTOME_KERATINIZATION	LCE1C LCE3D LCE1B LCE1E LCE1D SPRR2A SPRR2B LCE1A SPRR2D LCE2D SPRR2E LCE2C SPRR2F LCE3B SPRR2G LCE1F LCE2A LCE4A LCE3E LCE3C LCE5A LCE2B	4.47e-41	217	22	22	M27640
Pathway	REACTOME_DEVELOPMENTAL_BIOLOGY	LCE1C LCE3D LCE1B LCE1E LCE1D SPRR2A SPRR2B LCE1A SPRR2D LCE2D SPRR2E LCE2C SPRR2F LCE3B SPRR2G LCE1F LCE2A LCE4A LCE3E LCE3C LCE5A LCE2B	1.22e-22	1432	22	22	M509
Pathway	WP_VITAMIN_D_RECEPTOR_PATHWAY	LCE1D LCE1F LCE2B	2.85e-03	185	22	3	M39718
Pubmed	Late cornified envelope family in differentiating epithelia--response to calcium and ultraviolet irradiation.	LCE1C LCE3D LCE1B LCE1E LCE1D LCE1A LCE2D LCE2C LCE3B LCE1F LCE2A LCE4A LCE3E LCE3C LCE5A LCE2B	8.37e-50	22	23	16	15854049
Pubmed	Differentially expressed late constituents of the epidermal cornified envelope.	LCE1C LCE3D LCE1B LCE1E LCE1D LCE1A LCE2D LCE2C LCE3B LCE1F LCE2A LCE4A LCE3E LCE3C LCE5A LCE2B	2.75e-49	23	23	16	11698679
Pubmed	Rodent Lce gene clusters; new nomenclature, gene organization, and divergence of human and rodent genes.	LCE1C LCE3D LCE1B LCE1E LCE1D LCE1A LCE2D LCE2C LCE3B LCE2A LCE3E LCE3C LCE5A LCE2B	2.26e-45	16	23	14	17410201
Pubmed	The DNA sequence and biological annotation of human chromosome 1.	LCE1C LCE3D LCE1B LCE1E LCE1D SPRR2A SPRR2B LCE1A SPRR2D LCE2D SPRR2E LCE2C SPRR2F LCE3B SPRR2G LCE1F LCE2A LCE4A LCE3E LCE3C LCE5A	1.60e-30	1031	23	21	16710414
Pubmed	Assessment of community efforts to advance network-based prediction of protein-protein interactions.	LCE1C LCE3D LCE1B LCE1E LCE1D LCE1A LCE2D LCE2C LCE3B LCE1F LCE2A LCE4A LCE3E LCE3C LCE5A LCE2B	2.43e-23	630	23	16	36949045
Pubmed	Estrogen regulates the expression of the small proline-rich 2 gene family in the mouse uterus.	SPRR2A SPRR2B SPRR2D SPRR2E SPRR2F SPRR2G	1.15e-18	8	23	6	15232223
Pubmed	Molecular characterization and evolution of the SPRR family of keratinocyte differentiation markers encoding small proline-rich proteins.	SPRR2A SPRR2B SPRR2D SPRR2E SPRR2F SPRR2G	8.61e-18	10	23	6	8325635
Pubmed	A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition, and activity.	LCE3D SPRR2A SPRR2B SPRR2E SPRR2F LCE3B LCE3E LCE3C	3.06e-17	62	23	8	26644517
Pubmed	Association of psoriasis to PGLYRP and SPRR genes at PSORS4 locus on 1q shows heterogeneity between Finnish, Swedish and Irish families.	SPRR2A SPRR2B SPRR2D SPRR2E SPRR2F SPRR2G	3.79e-17	12	23	6	18643845
Pubmed	Mouse Sprr2 genes: a clustered family of genes showing differential expression in epithelial tissues.	SPRR2A SPRR2B SPRR2D SPRR2E SPRR2F SPRR2G	3.79e-17	12	23	6	9888996
Pubmed	CYSRT1: An Antimicrobial Epidermal Protein that Can Interact with Late Cornified Envelope Proteins.	LCE1B LCE2C LCE4A LCE3C LCE5A	1.67e-15	7	23	5	36804407
Pubmed	Structural organization and regulation of the small proline-rich family of cornified envelope precursors suggest a role in adaptive barrier function.	SPRR2B SPRR2D SPRR2E SPRR2F SPRR2G	9.98e-15	9	23	5	11279051
Pubmed	Molecular cloning and characterization of a novel mouse epidermal differentiation gene and its promoter.	LCE3D LCE3B LCE3E LCE3C	1.45e-13	4	23	4	11350120
Pubmed	Liver repopulation and correction of metabolic liver disease by transplanted adult mouse pancreatic cells.	LCE3D LCE3B LCE3E LCE3C	7.26e-13	5	23	4	11159194
Pubmed	Keratin 5-Cre-driven deletion of Ncstn in an acne inversa-like mouse model leads to a markedly increased IL-36a and Sprr2 expression.	SPRR2A SPRR2B SPRR2E SPRR2F	5.08e-12	7	23	4	31884525
Pubmed	Long-range comparison of human and mouse Sprr loci to identify conserved noncoding sequences involved in coordinate regulation.	SPRR2A SPRR2B SPRR2E SPRR2F	1.02e-11	8	23	4	15574822
Pubmed	Lessons from loricrin-deficient mice: compensatory mechanisms maintaining skin barrier function in the absence of a major cornified envelope protein.	SPRR2A SPRR2B SPRR2E SPRR2F	1.02e-11	8	23	4	11038185
Pubmed	Mouse Sprr locus: a tandem array of coordinately regulated genes.	SPRR2A SPRR2B SPRR2E SPRR2F	1.02e-11	8	23	4	12584609
Pubmed	Fate and plasticity of the epidermis in response to congenital activation of BRAF.	LCE3D LCE3B LCE3E LCE3C	1.03e-10	13	23	4	25202828
Pubmed	The mineralocorticoid receptor plays a transient role in mouse skin development.	SPRR2A SPRR2B SPRR2E SPRR2F	1.03e-10	13	23	4	26268211
Pubmed	Novel markers of early ovarian pre-granulosa cells are expressed in an Sry-like pattern.	SPRR2A SPRR2B SPRR2E SPRR2F	1.45e-10	14	23	4	19301398
Pubmed	Amniotic fluid activates the nrf2/keap1 pathway to repair an epidermal barrier defect in utero.	SPRR2A SPRR2B SPRR2E SPRR2F	1.45e-10	14	23	4	23237955
Pubmed	Glucocorticoid receptor regulates overlapping and differential gene subsets in developing and adult skin.	SPRR2A SPRR2B SPRR2E SPRR2F	1.97e-10	15	23	4	20880987
Pubmed	p63 regulates Satb1 to control tissue-specific chromatin remodeling during development of the epidermis.	LCE3D LCE3B LCE3E LCE3C	2.63e-10	16	23	4	21930775
Pubmed	XY Sox9 embryonic loss-of-function mouse mutants show complete sex reversal and produce partially fertile XY oocytes.	SPRR2A SPRR2B SPRR2E SPRR2F	6.99e-10	20	23	4	21466799
Pubmed	Association between LCE gene polymorphisms and psoriasis vulgaris among Mongolians from Inner Mongolia.	LCE1C LCE3D LCE1B	1.01e-09	4	23	3	29397434
Pubmed	Expression and regulation of cornified envelope proteins in human corneal epithelium.	SPRR2A SPRR2B SPRR2D	1.01e-09	4	23	3	16639001
Pubmed	Simultaneous gene deletion of gata4 and gata6 leads to early disruption of follicular development and germ cell loss in the murine ovary.	SPRR2A SPRR2B SPRR2E SPRR2F	1.05e-09	22	23	4	24899573
Pubmed	The Grainyhead-like epithelial transactivator Get-1/Grhl3 regulates epidermal terminal differentiation and interacts functionally with LMO4.	SPRR2A SPRR2B SPRR2E SPRR2F	1.05e-09	22	23	4	16949565
Pubmed	Insulin/IGF-1 controls epidermal morphogenesis via regulation of FoxO-mediated p63 inhibition.	LCE3D LCE3B LCE3E LCE3C	1.82e-09	25	23	4	23906066
Pubmed	Keratin 1 maintains skin integrity and participates in an inflammatory network in skin through interleukin-18.	LCE3D LCE3B LCE3E LCE3C	1.82e-09	25	23	4	23132931
Pubmed	Cdc42 Deficiency Leads To Epidermal Barrier Dysfunction by Regulating Intercellular Junctions and Keratinization of Epidermal Cells during Mouse Skin Development.	SPRR2A SPRR2B SPRR2E SPRR2F	1.82e-09	25	23	4	31410202
Pubmed	Pax9 is required for filiform papilla development and suppresses skin-specific differentiation of the mammalian tongue epithelium.	LCE3D LCE3B LCE3E LCE3C	2.15e-09	26	23	4	15454262
Pubmed	Isolation, characterization, and UV-stimulated expression of two families of genes encoding polypeptides of related structure in human epidermal keratinocytes.	SPRR2B SPRR2D SPRR2E	2.52e-09	5	23	3	3133554
Pubmed	ZFP750 affects the cutaneous barrier through regulating lipid metabolism.	SPRR2A SPRR2B SPRR2E SPRR2F	4.52e-09	31	23	4	37115925
Pubmed	Ets1 blocks terminal differentiation of keratinocytes and induces expression of matrix metalloproteases and innate immune mediators.	LCE3D LCE3B LCE3E LCE3C	4.52e-09	31	23	4	20930145
Pubmed	Ovarian development in mice requires the GATA4-FOG2 transcription complex.	SPRR2A SPRR2B SPRR2E SPRR2F	8.44e-09	36	23	4	18927154
Pubmed	New candidate genes identified for controlling mouse gonadal sex determination and the early stages of granulosa and Sertoli cell differentiation.	SPRR2A SPRR2B SPRR2E SPRR2F	1.31e-08	40	23	4	19864314
Pubmed	Protein-protein interaction panel using mouse full-length cDNAs.	LCE2D LCE2C LCE2A LCE5A LCE2B	6.28e-08	161	23	5	11591653
Pubmed	Altered keratinocyte differentiation is an early driver of keratin mutation-based palmoplantar keratoderma.	SPRR2A SPRR2B SPRR2E SPRR2F	6.91e-08	60	23	4	31220272
Pubmed	Psoriasis risk genes of the late cornified envelope-3 group are distinctly expressed compared with genes of other LCE groups.	LCE3B LCE3C	4.18e-07	2	23	2	21435436
Pubmed	Deletion of the late cornified envelope genes, LCE3C and LCE3B, is associated with rheumatoid arthritis.	LCE3B LCE3C	4.18e-07	2	23	2	20213803
Pubmed	A replication study of the association between rheumatoid arthritis and deletion of the late cornified envelope genes LCE3B and LCE3C.	LCE3B LCE3C	4.18e-07	2	23	2	22384135
Pubmed	Deletion of LCE3C and LCE3B is a susceptibility factor for psoriatic arthritis: a study in Spanish and Italian populations and meta-analysis.	LCE3B LCE3C	4.18e-07	2	23	2	21400479
Pubmed	Deletion of late cornified envelope genes, LCE3C_LCE3B-del, is not associated with psoriatic arthritis in Tunisian patients.	LCE3B LCE3C	4.18e-07	2	23	2	24566688
Pubmed	Deletion of LCE3C_LCE3B is associated with rheumatoid arthritis and systemic lupus erythematosus in the Chinese Han population.	LCE3B LCE3C	4.18e-07	2	23	2	21628307
Pubmed	Deletion of the late cornified envelope genes LCE3C and LCE3B is associated with psoriasis in a Chinese population.	LCE3B LCE3C	4.18e-07	2	23	2	21509048
Pubmed	LCE3C_LCE3B-del genotype and psoriasis: a summative meta-analysis.	LCE3B LCE3C	4.18e-07	2	23	2	20624365
Pubmed	Association between the LCE3C_LCE3B deletion polymorphism and susceptibility to psoriasis: a meta-analysis of published studies.	LCE3B LCE3C	4.18e-07	2	23	2	23631431
Pubmed	Deletion of LCE3C and LCE3B genes is associated with psoriasis in a northern Chinese population.	LCE3B LCE3C	4.18e-07	2	23	2	21711330
Pubmed	Deletion of Late Cornified Envelope 3B and 3C genes is not associated with atopic dermatitis.	LCE3B LCE3C	4.18e-07	2	23	2	20376060
Pubmed	Failure to find evidence for deletion of LCE3C and LCE3B genes at PSORS4 contributing to psoriasis susceptibility in Tunisian families.	LCE3B LCE3C	4.18e-07	2	23	2	24485035
Pubmed	Deletion of the late cornified envelope genes LCE3B and LCE3C may promote chronic hand eczema with allergic contact dermatitis.	LCE3B LCE3C	4.18e-07	2	23	2	21995181
Pubmed	Koebner phenomenon in psoriasis is not associated with deletion of late cornified envelope genes LCE3B and LCE3C.	LCE3B LCE3C	4.18e-07	2	23	2	22048733
Pubmed	Mutation analysis of the LCE3B/LCE3C genes in Psoriasis.	LCE3B LCE3C	4.18e-07	2	23	2	20331852
Pubmed	Association analysis of LCE3C-LCE3B deletion in Tunisian psoriatic population.	LCE3B LCE3C	4.18e-07	2	23	2	22926764
Pubmed	Antimicrobial Late Cornified Envelope Proteins: The Psoriasis Risk Factor Deletion of LCE3B/C Genes Affects Microbiota Composition.	LCE3B LCE3C	4.18e-07	2	23	2	34942199
Pubmed	Structural and transglutaminase substrate properties of the small proline-rich 2 family of cornified cell envelope proteins.	SPRR2B SPRR2E	1.25e-06	3	23	2	9722562
Pubmed	Psoriasis-Associated Late Cornified Envelope (LCE) Proteins Have Antibacterial Activity.	LCE3B LCE3C	1.25e-06	3	23	2	28634035
Pubmed	Meta-analysis confirms the LCE3C_LCE3B deletion as a risk factor for psoriasis in several ethnic groups and finds interaction with HLA-Cw6.	LCE3B LCE3C	1.25e-06	3	23	2	21107349
Pubmed	Deletion of the late cornified envelope LCE3B and LCE3C genes as a susceptibility factor for psoriasis.	LCE3B LCE3C	1.25e-06	3	23	2	19169253
Pubmed	Replication of LCE3C-LCE3B CNV as a risk factor for psoriasis and analysis of interaction with other genetic risk factors.	LCE3B LCE3C	1.25e-06	3	23	2	20016497
Pubmed	Increased Risk of Psoriasis due to combined effect of HLA-Cw6 and LCE3 risk alleles in Indian population.	LCE3B LCE3C	2.51e-06	4	23	2	27048876
Pubmed	Paediatric-onset psoriasis is associated with ERAP1 and IL23R loci, LCE3C_LCE3B deletion and HLA-C*06.	LCE3B LCE3C	4.18e-06	5	23	2	22512642
Pubmed	Cdh1-APC Regulates Protein Synthesis and Stress Granules in Neurons through an FMRP-Dependent Mechanism.	SPRR2A SPRR2B SPRR2E SPRR2F	8.13e-06	197	23	4	32434143
Pubmed	Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.	SPRR2A SPRR2B SPRR2D SPRR2E SPRR2F SPRR2G	2.18e-05	910	23	6	36736316
Pubmed	Creation of genome-wide protein expression libraries using random activation of gene expression.	SPRR2D SPRR2E LCE2A LCE2B	9.22e-05	367	23	4	11329013
Pubmed	GREB1: An evolutionarily conserved protein with a glycosyltransferase domain links ERα glycosylation and stability to cancer.	LCE1C SPRR2A LCE2B	4.19e-04	223	23	3	33731348
Pubmed	Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.	SPRR2A SPRR2B SPRR2E	5.56e-03	552	23	3	10737800
Pubmed	Systematic analysis of human protein complexes identifies chromosome segregation proteins.	SPRR2B SPRR2D SPRR2E SPRR2G	6.47e-03	1155	23	4	20360068
Interaction	KRTAP5-2 interactions	LCE1C LCE3D LCE1B LCE1E LCE1D LCE1A LCE2D LCE2C LCE3B LCE1F LCE2A LCE4A LCE3E LCE3C LCE5A LCE2B	5.72e-37	62	22	16	int:KRTAP5-2
Interaction	KRTAP5-4 interactions	LCE1C LCE3D LCE1B LCE1E LCE1D LCE1A LCE2D LCE2C LCE3B LCE1F LCE2A LCE4A LCE3E LCE3C LCE5A LCE2B	7.67e-37	63	22	16	int:KRTAP5-4
Interaction	KRTAP4-5 interactions	LCE1C LCE3D LCE1B LCE1E LCE1D LCE1A LCE2D LCE2C LCE3B LCE1F LCE2A LCE4A LCE3E LCE3C LCE5A LCE2B	2.26e-35	76	22	16	int:KRTAP4-5
Interaction	KRTAP4-4 interactions	LCE1C LCE3D LCE1B LCE1E LCE1D LCE1A LCE2D LCE2C LCE3B LCE1F LCE2A LCE4A LCE3E LCE3C LCE5A LCE2B	7.00e-35	81	22	16	int:KRTAP4-4
Interaction	KRTAP4-11 interactions	LCE1C LCE3D LCE1B LCE1E LCE1D LCE1A LCE2D LCE2C LCE3B LCE1F LCE2A LCE4A LCE3E LCE3C LCE5A LCE2B	6.55e-34	92	22	16	int:KRTAP4-11
Interaction	KRTAP5-6 interactions	LCE1C LCE3D LCE1B LCE1E LCE1D LCE1A LCE2D LCE2C LCE3B LCE1F LCE2A LCE4A LCE3E LCE3C LCE5A LCE2B	9.52e-34	94	22	16	int:KRTAP5-6
Interaction	KRTAP10-11 interactions	LCE1C LCE3D LCE1B LCE1E LCE1D LCE1A LCE2D LCE3B LCE1F LCE2A LCE4A LCE3E LCE3C LCE5A LCE2B	9.58e-34	64	22	15	int:KRTAP10-11
Interaction	KRTAP5-3 interactions	LCE1C LCE3D LCE1B LCE1E LCE1D LCE1A LCE2D LCE2C LCE3B LCE1F LCE4A LCE3E LCE3C LCE5A LCE2B	1.61e-33	66	22	15	int:KRTAP5-3
Interaction	KRTAP9-8 interactions	LCE1C LCE3D LCE1B LCE1E LCE1D LCE1A LCE2D LCE2C LCE3B LCE1F LCE2A LCE4A LCE3E LCE3C LCE5A LCE2B	2.79e-33	100	22	16	int:KRTAP9-8
Interaction	RGS17 interactions	LCE3D LCE1B LCE1E LCE1D LCE1A LCE2C LCE3B LCE1F LCE2A LCE4A LCE3E LCE3C LCE5A LCE2B	7.32e-33	48	22	14	int:RGS17
Interaction	LCE2B interactions	LCE1C LCE3D LCE1B LCE1E LCE1D LCE1A LCE2D LCE2C LCE3B LCE1F LCE2A LCE4A LCE3C LCE5A LCE2B	4.86e-32	81	22	15	int:LCE2B
Interaction	KRTAP10-6 interactions	LCE3D LCE1B LCE1E LCE1D LCE1A LCE2D LCE2C LCE3B LCE1F LCE2A LCE4A LCE3E LCE3C LCE5A LCE2B	1.89e-31	88	22	15	int:KRTAP10-6
Interaction	KRTAP4-2 interactions	LCE1C LCE3D LCE1B LCE1E LCE1D LCE1A LCE2D LCE2C LCE3B LCE1F LCE2A LCE4A LCE3E LCE3C LCE5A LCE2B	3.23e-31	132	22	16	int:KRTAP4-2
Interaction	KRTAP9-3 interactions	LCE1C LCE3D LCE1B LCE1E LCE1D LCE1A LCE2D LCE2C LCE3B LCE1F LCE2A LCE4A LCE3E LCE3C LCE5A LCE2B	8.75e-31	140	22	16	int:KRTAP9-3
Interaction	KRTAP5-11 interactions	LCE1C LCE3D LCE1B LCE1E LCE1D LCE1A LCE2C LCE3B LCE1F LCE2A LCE4A LCE3E LCE3C LCE5A	1.17e-30	66	22	14	int:KRTAP5-11
Interaction	LCE2A interactions	LCE1C LCE3D LCE1B LCE1D LCE1A LCE2D LCE2C LCE3B LCE1F LCE2A LCE4A LCE3E LCE5A LCE2B	2.33e-30	69	22	14	int:LCE2A
Interaction	KRTAP9-2 interactions	LCE1C LCE3D LCE1B LCE1E LCE1D LCE1A LCE2D LCE2C LCE3B LCE1F LCE2A LCE4A LCE3E LCE3C LCE5A LCE2B	2.50e-30	149	22	16	int:KRTAP9-2
Interaction	KRTAP10-1 interactions	LCE1C LCE3D LCE1B LCE1E LCE1D LCE1A LCE2D LCE2C LCE3B LCE1F LCE2A LCE4A LCE3E LCE3C LCE5A LCE2B	3.90e-30	153	22	16	int:KRTAP10-1
Interaction	KRTAP1-5 interactions	LCE3D LCE1B LCE1E LCE1D LCE1A LCE2D LCE2C LCE1F LCE2A LCE4A LCE3E LCE5A LCE2B	6.54e-30	48	22	13	int:KRTAP1-5
Interaction	LCE2D interactions	LCE1C LCE3D LCE1B LCE1E LCE1D LCE1A LCE2D LCE2C LCE1F LCE2A LCE4A LCE3C LCE5A LCE2B	6.85e-30	74	22	14	int:LCE2D
Interaction	KRTAP10-5 interactions	LCE1C LCE3D LCE1B LCE1E LCE1D LCE1A LCE2D LCE2C LCE3B LCE1F LCE2A LCE4A LCE3E LCE3C LCE5A LCE2B	8.27e-30	160	22	16	int:KRTAP10-5
Interaction	KRTAP4-12 interactions	LCE1C LCE3D LCE1B LCE1E LCE1D LCE1A LCE2D LCE2C LCE3B LCE1F LCE2A LCE4A LCE3E LCE3C LCE5A LCE2B	9.18e-30	161	22	16	int:KRTAP4-12
Interaction	LCE1B interactions	LCE1C LCE1B LCE1E LCE1D LCE1A LCE2D LCE2C LCE3B LCE1F LCE2A LCE4A LCE3C LCE5A LCE2B	5.68e-29	85	22	14	int:LCE1B
Interaction	LCE2C interactions	LCE1C LCE3D LCE1B LCE1E LCE1D LCE1A LCE2D LCE2C LCE3B LCE1F LCE2A LCE4A LCE5A LCE2B	9.61e-29	88	22	14	int:LCE2C
Interaction	LCE5A interactions	LCE1C LCE1B LCE1E LCE1D LCE1A LCE2D LCE2C LCE3B LCE1F LCE2A LCE4A LCE3C LCE5A LCE2B	1.35e-28	90	22	14	int:LCE5A
Interaction	LCE1F interactions	LCE1C LCE1B LCE1E LCE1D LCE1A LCE2D LCE2C LCE3B LCE1F LCE2A LCE4A LCE3C LCE5A LCE2B	1.88e-28	92	22	14	int:LCE1F
Interaction	KRTAP2-3 interactions	LCE1C LCE3D LCE1B LCE1E LCE1D LCE1A LCE2D LCE2C LCE1F LCE2A LCE3E LCE3C LCE5A LCE2B	3.05e-28	95	22	14	int:KRTAP2-3
Interaction	KRTAP5-9 interactions	LCE1C LCE3D LCE1B LCE1E LCE1D LCE1A LCE2D LCE2C LCE3B LCE1F LCE2A LCE4A LCE3E LCE3C LCE5A LCE2B	4.36e-28	203	22	16	int:KRTAP5-9
Interaction	KRTAP12-3 interactions	LCE1C LCE3D LCE1B LCE1E LCE1D LCE1A LCE2D LCE2C LCE1F LCE2A LCE4A LCE3E LCE3C LCE5A LCE2B	6.20e-28	146	22	15	int:KRTAP12-3
Interaction	KRTAP2-4 interactions	LCE1C LCE3D LCE1B LCE1E LCE1D LCE1A LCE2D LCE2C LCE1F LCE2A LCE3E LCE3C LCE5A LCE2B	7.63e-28	101	22	14	int:KRTAP2-4
Interaction	TRIM42 interactions	LCE1C LCE3D LCE1B LCE1E LCE1D LCE1A LCE2D LCE2C LCE1F LCE2A LCE4A LCE3E LCE3C LCE5A LCE2B	8.54e-28	149	22	15	int:TRIM42
Interaction	SPRY1 interactions	LCE1C LCE3D LCE1B LCE1E LCE1D LCE1A LCE2D LCE2C LCE1F LCE2A LCE4A LCE3E LCE3C LCE5A	3.12e-27	111	22	14	int:SPRY1
Interaction	LCE1C interactions	LCE1C LCE1B LCE1E LCE1D LCE1A LCE2D LCE2C LCE3B LCE1F LCE2A LCE4A LCE5A LCE2B	6.15e-27	77	22	13	int:LCE1C
Interaction	KRTAP10-9 interactions	LCE1C LCE3D LCE1B LCE1E LCE1D LCE1A LCE2D LCE2C LCE3B LCE1F LCE2A LCE4A LCE3E LCE3C LCE5A LCE2B	7.41e-27	241	22	16	int:KRTAP10-9
Interaction	RGS20 interactions	LCE3D LCE1B LCE1E LCE1D LCE1A LCE2D LCE2C LCE1F LCE2A LCE4A LCE3E LCE3C LCE5A LCE2B	7.71e-27	118	22	14	int:RGS20
Interaction	LCE4A interactions	LCE1C LCE1B LCE1E LCE1D LCE1A LCE2D LCE2C LCE1F LCE2A LCE4A LCE3C LCE5A LCE2B	1.05e-26	80	22	13	int:LCE4A
Interaction	LCE1A interactions	LCE1C LCE1B LCE1E LCE1A LCE2D LCE2C LCE3B LCE1F LCE2A LCE4A LCE3C LCE5A LCE2B	2.09e-26	84	22	13	int:LCE1A
Interaction	KRTAP1-3 interactions	LCE3D LCE1B LCE1E LCE1D LCE1A LCE2D LCE2C LCE3B LCE1F LCE2A LCE4A LCE3E LCE3C LCE5A LCE2B	2.30e-26	184	22	15	int:KRTAP1-3
Interaction	KRTAP1-1 interactions	LCE3D LCE1B LCE1E LCE1D LCE1A LCE2D LCE2C LCE3B LCE1F LCE2A LCE4A LCE3E LCE3C LCE5A LCE2B	3.42e-25	219	22	15	int:KRTAP1-1
Interaction	LCE1E interactions	LCE1C LCE1B LCE1E LCE1D LCE1A LCE2D LCE2C LCE3B LCE1F LCE4A LCE5A LCE2B	4.91e-25	68	22	12	int:LCE1E
Interaction	LCE1D interactions	LCE1C LCE1B LCE1E LCE1D LCE2D LCE2C LCE3B LCE1F LCE2A LCE4A LCE5A LCE2B	7.17e-25	70	22	12	int:LCE1D
Interaction	KRTAP5-7 interactions	LCE3D LCE1B LCE1E LCE1A LCE2D LCE2C LCE3B LCE1F LCE2A LCE4A LCE3E LCE2B	8.63e-25	71	22	12	int:KRTAP5-7
Interaction	LCE3B interactions	LCE1C LCE1B LCE1E LCE1D LCE1A LCE2C LCE3B LCE1F LCE2A LCE5A LCE2B	1.66e-24	46	22	11	int:LCE3B
Interaction	KRTAP4-1 interactions	LCE3D LCE1B LCE1D LCE1A LCE2D LCE2C LCE1F LCE3E LCE3C LCE5A	9.33e-24	31	22	10	int:KRTAP4-1
Interaction	KRTAP10-7 interactions	LCE3D LCE1B LCE1E LCE1D LCE1A LCE2D LCE2C LCE3B LCE1F LCE2A LCE4A LCE3E LCE3C LCE5A LCE2B	2.98e-23	293	22	15	int:KRTAP10-7
Interaction	KRTAP10-8 interactions	LCE1C LCE3D LCE1B LCE1E LCE1D LCE1A LCE2D LCE2C LCE3B LCE1F LCE2A LCE4A LCE3E LCE3C LCE5A LCE2B	3.00e-23	401	22	16	int:KRTAP10-8
Interaction	ADAMTSL4 interactions	LCE1C LCE3D LCE1B LCE1D LCE1A LCE2D LCE2C LCE1F LCE2A LCE4A LCE3E LCE3C LCE5A LCE2B	5.47e-23	217	22	14	int:ADAMTSL4
Interaction	NBPF19 interactions	LCE3D LCE1B LCE1E LCE1D LCE1A LCE2D LCE2C LCE1F LCE2A LCE4A LCE3E LCE3C LCE5A LCE2B	1.52e-22	233	22	14	int:NBPF19
Interaction	ALPP interactions	LCE1C LCE3D LCE1B LCE1E LCE1D LCE2C LCE3B LCE1F LCE4A LCE3E LCE3C LCE5A	9.46e-22	123	22	12	int:ALPP
Interaction	CYSRT1 interactions	LCE1C LCE3D LCE1B LCE1E LCE1D LCE1A LCE2D LCE2C LCE3B LCE1F LCE2A LCE4A LCE3E LCE3C LCE5A LCE2B	1.50e-21	511	22	16	int:CYSRT1
Interaction	KRTAP12-4 interactions	LCE1C LCE3D LCE1B LCE1E LCE1A LCE2C LCE1F LCE2A LCE4A LCE5A	4.05e-21	53	22	10	int:KRTAP12-4
Interaction	KRTAP6-3 interactions	LCE1C LCE3D LCE1B LCE1E LCE1A LCE2C LCE1F LCE2A LCE3E LCE3C LCE5A LCE2B	2.69e-20	161	22	12	int:KRTAP6-3
Interaction	HOXA1 interactions	LCE1C LCE3D LCE1B LCE1D LCE1A LCE2D LCE2C LCE1F LCE2A LCE4A LCE3E LCE3C LCE5A LCE2B	6.29e-20	356	22	14	int:HOXA1
Interaction	CHIC2 interactions	LCE1C LCE3D LCE1B LCE1D LCE1A LCE2C LCE1F LCE3E LCE3C LCE5A	1.28e-19	73	22	10	int:CHIC2
Interaction	NOTCH2NLA interactions	LCE3D LCE1B LCE1E LCE1D LCE1A LCE2D LCE2C LCE1F LCE2A LCE4A LCE3E LCE3C LCE5A LCE2B	1.64e-19	381	22	14	int:NOTCH2NLA
Interaction	SMCP interactions	LCE1B LCE1E LCE1D LCE1A LCE2D LCE2C LCE3B LCE1F LCE4A LCE5A	2.95e-19	79	22	10	int:SMCP
Interaction	VASN interactions	LCE1C LCE1B LCE1A LCE2D LCE2C LCE1F LCE2A LCE4A LCE3C LCE5A LCE2B	3.65e-18	160	22	11	int:VASN
Interaction	VWC2 interactions	LCE1C LCE3D LCE1A LCE2D LCE2C LCE1F LCE4A LCE3E LCE5A	6.49e-18	62	22	9	int:VWC2
Interaction	KRTAP12-1 interactions	LCE1C LCE1B LCE1E LCE1A LCE2C LCE1F LCE2A LCE5A LCE2B	7.56e-18	63	22	9	int:KRTAP12-1
Interaction	KRTAP17-1 interactions	LCE3D LCE1B LCE1E LCE2D LCE2C LCE4A LCE3C LCE2B	1.75e-16	48	22	8	int:KRTAP17-1
Interaction	KRTAP10-10 interactions	LCE1C LCE1B LCE1E LCE2C LCE3B LCE1F LCE3C	5.59e-16	27	22	7	int:KRTAP10-10
Interaction	CRCT1 interactions	LCE1C LCE1D LCE1A LCE2C LCE1F LCE2A LCE4A LCE2B	2.63e-15	66	22	8	int:CRCT1
Interaction	CYP21A2 interactions	LCE3D LCE1D LCE2C LCE3B LCE1F LCE3C LCE5A	2.68e-15	33	22	7	int:CYP21A2
Interaction	LCE3C interactions	LCE1B LCE1A LCE2D LCE1F LCE4A LCE3C LCE5A LCE2B	2.98e-15	67	22	8	int:LCE3C
Interaction	KRTAP3-2 interactions	LCE3D LCE1B LCE1A LCE1F LCE2A LCE4A LCE3E LCE3C	1.18e-14	79	22	8	int:KRTAP3-2
Interaction	MACO1 interactions	LCE1C LCE3D LCE1E LCE1D LCE1A LCE2C LCE1F LCE3E LCE5A	1.03e-13	175	22	9	int:MACO1
Interaction	GRN interactions	LCE1B LCE1E LCE1D LCE1A LCE2D LCE4A LCE3E LCE3C LCE5A LCE2B	1.32e-13	281	22	10	int:GRN
Interaction	KRTAP12-2 interactions	LCE1C LCE1B LCE1A LCE1F LCE2A LCE4A LCE5A LCE2B	6.30e-13	128	22	8	int:KRTAP12-2
Interaction	EFEMP2 interactions	LCE1C LCE3D LCE1E LCE1A LCE2D LCE2C LCE3E LCE3C	1.03e-12	136	22	8	int:EFEMP2
Interaction	SPRY3 interactions	LCE3D LCE1B LCE1A LCE1F LCE3E LCE2B	1.28e-12	35	22	6	int:SPRY3
Interaction	LCE3A interactions	LCE1C LCE2D LCE2C LCE3B LCE2A LCE4A LCE2B	1.33e-12	76	22	7	int:LCE3A
Interaction	SPRY2 interactions	LCE1C LCE1B LCE1A LCE2D LCE1F LCE4A LCE3E LCE3C	2.54e-12	152	22	8	int:SPRY2
Interaction	OTX1 interactions	LCE1C LCE1B LCE2D LCE2C LCE1F LCE2A LCE4A LCE2B	2.98e-12	155	22	8	int:OTX1
Interaction	TSPAN4 interactions	LCE3D LCE1A LCE2D LCE4A LCE3C LCE2B	1.78e-11	53	22	6	int:TSPAN4
Interaction	TGFB1 interactions	LCE1C LCE3D LCE1D LCE1A LCE2C LCE3B LCE1F LCE5A LCE2B	2.19e-11	317	22	9	int:TGFB1
Interaction	PLA2G10 interactions	LCE1C LCE1A LCE2D LCE1F LCE2A LCE5A LCE2B	2.30e-11	113	22	7	int:PLA2G10
Interaction	NUFIP2 interactions	LCE1B LCE1D LCE2D LCE2C LCE1F LCE4A LCE3C LCE5A LCE2B	2.50e-10	417	22	9	int:NUFIP2
Interaction	KRTAP3-3 interactions	LCE3D LCE1F LCE4A LCE3E LCE3C LCE2B	2.67e-10	82	22	6	int:KRTAP3-3
Interaction	MDFI interactions	LCE3D LCE1B LCE1D LCE1A LCE1F LCE4A LCE3E LCE3C LCE2B	3.28e-10	430	22	9	int:MDFI
Interaction	SLC39A7 interactions	LCE1C LCE1A LCE2D LCE2C LCE1F LCE4A LCE5A	8.02e-10	187	22	7	int:SLC39A7
Interaction	PTK6 interactions	SPRR2A SPRR2B SPRR2D SPRR2E SPRR2F SPRR2G	1.14e-09	104	22	6	int:PTK6
Interaction	KRTAP11-1 interactions	LCE1B LCE1A LCE1F LCE2A LCE3C LCE2B	1.43e-09	108	22	6	int:KRTAP11-1
Interaction	CATSPER1 interactions	LCE1B LCE1E LCE1D LCE2C LCE1F LCE5A	3.64e-09	126	22	6	int:CATSPER1
Interaction	FBLN1 interactions	LCE1C LCE1B LCE1D LCE1A LCE1F LCE5A	4.20e-09	129	22	6	int:FBLN1
Interaction	LCE3D interactions	LCE3D LCE2D LCE2C LCE2A LCE2B	1.36e-08	73	22	5	int:LCE3D
Interaction	NECTIN2 interactions	LCE1C LCE1E LCE2C LCE1F LCE5A LCE2B	1.47e-08	159	22	6	int:NECTIN2
Interaction	CREB5 interactions	LCE1C LCE2C LCE1F LCE2A LCE4A LCE5A	1.77e-08	164	22	6	int:CREB5
Interaction	PLAC8 interactions	LCE1C LCE1A LCE5A LCE2B	1.84e-08	27	22	4	int:PLAC8
Interaction	KRTAP3-1 interactions	LCE3D LCE1B LCE4A LCE5A LCE2B	2.95e-08	85	22	5	int:KRTAP3-1
Interaction	KRTAP9-4 interactions	LCE1B LCE4A LCE3E LCE3C	4.27e-08	33	22	4	int:KRTAP9-4
Interaction	VWC2L interactions	LCE1C LCE3D LCE1A LCE5A	9.48e-08	40	22	4	int:VWC2L
Interaction	PCSK5 interactions	LCE3D LCE1D LCE2C LCE1F LCE3C	1.18e-07	112	22	5	int:PCSK5
Interaction	FUCA2 interactions	LCE1B LCE1E LCE1A LCE4A	1.28e-07	43	22	4	int:FUCA2
Interaction	PLSCR3 interactions	LCE1C LCE4A LCE5A LCE2B	2.01e-07	48	22	4	int:PLSCR3
Interaction	PLSCR2 interactions	LCE1A LCE3E LCE5A	6.26e-07	16	22	3	int:PLSCR2
Interaction	PLSCR4 interactions	LCE1C LCE1A LCE5A LCE2B	1.23e-06	75	22	4	int:PLSCR4
Interaction	POU4F2 interactions	LCE1C LCE2C LCE1F LCE5A	1.85e-06	83	22	4	int:POU4F2
Interaction	GUCD1 interactions	LCE1C LCE2D LCE2A LCE2B	2.34e-06	88	22	4	int:GUCD1
Interaction	KRTAP21-2 interactions	LCE1A LCE2A LCE5A	4.98e-06	31	22	3	int:KRTAP21-2
Interaction	NTAQ1 interactions	LCE1C LCE1E LCE1D LCE2C LCE1F LCE5A	5.16e-06	431	22	6	int:NTAQ1
Cytoband	Ensembl 112 genes in cytogenetic band chr1q21	LCE1C LCE3D LCE1B LCE1E LCE1D SPRR2A SPRR2B LCE1A SPRR2D LCE2D SPRR2E LCE2C SPRR2F LCE3B SPRR2G LCE1F LCE2A LCE4A LCE3E SPRR5 LCE3C LCE5A LCE2B	2.81e-48	404	23	23	chr1q21
Cytoband	1q21.3	LCE1C LCE1B LCE1E LCE1D LCE1A LCE2D LCE2C LCE3B LCE1F LCE2A LCE4A LCE3E LCE3C LCE5A	1.74e-31	117	23	14	1q21.3
Cytoband	1q21-q22	SPRR2A SPRR2B SPRR2D SPRR2E SPRR2F SPRR2G	7.80e-16	23	23	6	1q21-q22
Cytoband	1q21	LCE3D LCE2B	9.57e-04	91	23	2	1q21
GeneFamily	Late cornified envelope proteins	LCE1C LCE3D LCE1B LCE1E LCE1D LCE1A LCE2D LCE2C LCE3B LCE1F LCE2A LCE4A LCE3E LCE3C LCE5A LCE2B	1.84e-48	18	22	16	627
GeneFamily	Small proline rich proteins	SPRR2A SPRR2B SPRR2D SPRR2E SPRR2F SPRR2G	7.08e-16	11	22	6	1353
Coexpression	JARDIM_PERASSI_TRIPLE_NEGATIVE_BREAST_CANCER_MOUSE_XENOGRAFT_MELATONIN_UP	LCE1C LCE1B LCE1E LCE1D LCE1A LCE2D LCE2C LCE2A LCE5A LCE2B	6.78e-23	49	21	10	MM452
Coexpression	MARTINEZ_RB1_AND_TP53_TARGETS_UP	LCE1C LCE1B LCE1E LCE1D SPRR2A SPRR2B LCE1A LCE2D SPRR2E LCE2C SPRR2F LCE5A	2.34e-14	689	21	12	MM1041
Coexpression	MARTINEZ_TP53_TARGETS_UP	LCE1C LCE1B LCE1E LCE1D SPRR2A SPRR2B LCE1A LCE2D SPRR2E LCE2C SPRR2F LCE5A	2.55e-14	694	21	12	MM1039
Coexpression	HOLLERN_SQUAMOUS_BREAST_TUMOR	LCE1C LCE1B LCE1E LCE1D LCE1A LCE2D LCE2C LCE5A	2.19e-12	204	21	8	MM966
Coexpression	HUMMERICH_BENIGN_SKIN_TUMOR_UP	SPRR2A SPRR2B SPRR2E SPRR2F	1.46e-09	20	21	4	MM491
Coexpression	HUMMERICH_MALIGNANT_SKIN_TUMOR_UP	SPRR2A SPRR2B SPRR2E SPRR2F	2.67e-09	23	21	4	MM492
Coexpression	MARTINEZ_RB1_TARGETS_DN	LCE1C LCE1B LCE1E LCE1D LCE1A LCE2D LCE2C LCE5A	1.65e-08	630	21	8	MM1038
Coexpression	DARWICHE_SKIN_TUMOR_PROMOTER_UP	LCE3D LCE3B LCE3E LCE3C	6.18e-06	153	21	4	MM495
Coexpression	DARWICHE_SQUAMOUS_CELL_CARCINOMA_UP	LCE3D LCE3B LCE3E LCE3C	1.05e-05	175	21	4	MM501
Coexpression	DARWICHE_PAPILLOMA_RISK_HIGH_UP	LCE3D LCE3B LCE3E LCE3C	1.05e-05	175	21	4	MM499
Coexpression	DARWICHE_PAPILLOMA_RISK_LOW_UP	LCE3D LCE3B LCE3E LCE3C	1.51e-05	192	21	4	MM497
Coexpression	SESTO_RESPONSE_TO_UV_C1	SPRR2A SPRR2D SPRR2E	2.77e-05	74	21	3	M7933
Coexpression	DESCARTES_MAIN_FETAL_SQUAMOUS_EPITHELIAL_CELLS	SPRR2A SPRR2D SPRR2E	1.45e-04	129	21	3	M40122
Coexpression	BLANCO_MELO_COVID19_BRONCHIAL_EPITHELIAL_CELLS_SARS_COV_2_INFECTION_UP	SPRR2A SPRR2D SPRR2E	2.01e-04	144	21	3	M34020
Coexpression	IVANOVA_HEMATOPOIESIS_LATE_PROGENITOR	LCE3D LCE3B LCE3E LCE3C	8.52e-04	548	21	4	MM1013
Coexpression	MARTINEZ_RB1_TARGETS_UP	SPRR2A SPRR2B SPRR2E SPRR2F	2.58e-03	741	21	4	MM1037
CoexpressionAtlas	skin	LCE1C LCE3D LCE1B LCE1E LCE1D SPRR2B LCE1A LCE2D SPRR2E LCE2C SPRR2G LCE1F LCE2A LCE4A LCE3E LCE5A LCE2B	7.80e-25	456	22	17	skin
CoexpressionAtlas	tonsil	LCE3D SPRR2B SPRR2E SPRR2F LCE3B LCE3E LCE3C	4.63e-10	182	22	7	tonsil
CoexpressionAtlas	UniversalReference_WholeMouseP1_top-relative-expression-ranked_250	LCE1C LCE1B LCE1E LCE1D LCE1F LCE3C	5.08e-08	206	22	6	Facebase_ST1_Univ_250
CoexpressionAtlas	esophagus	SPRR2A SPRR2B SPRR2D SPRR2E SPRR2F LCE3E	1.49e-07	247	22	6	esophagus
CoexpressionAtlas	UniversalReference_WholeMouseP1_top-relative-expression-ranked_500	LCE1C LCE1B LCE1E LCE1D SPRR2A LCE1F LCE3C	1.66e-07	427	22	7	Facebase_ST1_Univ_500
CoexpressionAtlas	JC_iEC_top-relative-expression-ranked_2500_k-means-cluster#4	SPRR2A SPRR2B SPRR2D SPRR2E SPRR2F	3.76e-05	382	22	5	JC_iEC_2500_K4
CoexpressionAtlas	UniversalReference_WholeMouseP1_top-relative-expression-ranked_500_3	LCE1C LCE1D LCE3C	8.11e-05	82	22	3	Facebase_ST1_Univ_500_3
CoexpressionAtlas	Progenitor-Cell-Biology-Consortium_reference_BronchioEpithel_top-relative-expression-ranked_100	SPRR2A SPRR2B SPRR2D	1.38e-04	98	22	3	PCBC_ctl_BronchioEpithel_100
CoexpressionAtlas	dev gonad_e11.5_F_SupCellPrec_Sry_k-means-cluster#3_top-relative-expression-ranked_100	SPRR2A SPRR2D	3.81e-04	28	22	2	gudmap_dev gonad_e11.5_F_SupCellPrec_Sry_k3_100
CoexpressionAtlas	Progenitor-Cell-Biology-Consortium_reference_BronchioEpithel_top-relative-expression-ranked_1000	LCE3D SPRR2A SPRR2B SPRR2D SPRR2E SPRR2F	3.97e-04	990	22	6	PCBC_ctl_BronchioEpithel_1000
CoexpressionAtlas	UniversalReference_WholeMouseP1_top-relative-expression-ranked_500_5	LCE1B LCE1E	1.17e-03	49	22	2	Facebase_ST1_Univ_500_5
CoexpressionAtlas	dev gonad_e11.5_F_SupCellPrec_Sry_k-means-cluster#4_top-relative-expression-ranked_200	SPRR2A SPRR2D	1.42e-03	54	22	2	gudmap_dev gonad_e11.5_F_SupCellPrec_Sry_k4_200
CoexpressionAtlas	Progenitor-Cell-Biology-Consortium_reference_SmallAirwayEpithel_top-relative-expression-ranked_500	SPRR2A SPRR2B SPRR2D SPRR2F	1.51e-03	493	22	4	PCBC_ctl_SmallAirwayEpithel_500
CoexpressionAtlas	Progenitor-Cell-Biology-Consortium_reference_BronchioEpithel_top-relative-expression-ranked_500	SPRR2A SPRR2B SPRR2D SPRR2E	1.54e-03	496	22	4	PCBC_ctl_BronchioEpithel_500
CoexpressionAtlas	Progenitor-Cell-Biology-Consortium_reference_BronchSmoothMuscl_top-relative-expression-ranked_1000	SPRR2D LCE2C LCE1F LCE2A LCE2B	2.84e-03	981	22	5	PCBC_ctl_BronchSmoothMuscl_1000
ToppCell	TCGA-Skin-Primary_Tumor\|TCGA-Skin / Sample_Type by Project: Shred V9	LCE1C LCE3D SPRR2A SPRR2B LCE1A SPRR2D LCE2D SPRR2E LCE2C SPRR2G LCE1F LCE3E LCE2B	9.87e-26	190	23	13	e2b26a03c6ab24d9b0f4150c47597be37767d86e
ToppCell	TCGA-Skin-Primary_Tumor-Melanoma-Skin_Cutaneous_Melanoma\|TCGA-Skin / Sample_Type by Project: Shred V9	LCE1C LCE3D SPRR2A SPRR2B LCE1A SPRR2D LCE2D SPRR2E LCE2C SPRR2G LCE1F LCE3E LCE2B	9.87e-26	190	23	13	3188c7bd225cbcf46a21e2fb784336cdd9665995
ToppCell	TCGA-Skin-Primary_Tumor-Melanoma\|TCGA-Skin / Sample_Type by Project: Shred V9	LCE1C LCE3D SPRR2A SPRR2B LCE1A SPRR2D LCE2D SPRR2E LCE2C SPRR2G LCE1F LCE3E LCE2B	9.87e-26	190	23	13	01fb45add4661bc86cd0a34fac35177907152dbb
ToppCell	TCGA-Testes-Primary_Tumor-Testicular_Germ_Cell_Tumor-Non-Seminoma-_Embryonal_Carcinoma,_Immature_Teratoma,_Mature_Teratoma,_Yolk_Sac_Tumor-3\|TCGA-Testes / Sample_Type by Project: Shred V9	LCE1C LCE1D LCE1A LCE2D SPRR2E LCE2C LCE1F LCE2A LCE4A LCE3C LCE2B	6.37e-23	125	23	11	5f90de494b53ecce6455034f3ed5dccdbb2c29ca
ToppCell	TCGA-Head_and_Esophagus\|World / Sample_Type by Project: Shred V9	LCE3D SPRR2A SPRR2B SPRR2D SPRR2E SPRR2F SPRR2G LCE3E	1.81e-14	172	23	8	eb18aa179db1818f408c38e442ecfed8582d7dbc
ToppCell	Bronchial_Brush-Epithelial-Ciliated_2\|Bronchial_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X	LCE3D SPRR2A SPRR2B SPRR2D SPRR2E SPRR2F LCE3E	3.76e-13	132	23	7	780a391924f776dc6fbe44ddcf4ae0583a1e2157
ToppCell	Bronchial_Brush-Epithelial-Ciliated_2\|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X	LCE3D SPRR2A SPRR2B SPRR2D SPRR2E SPRR2F LCE3E	4.41e-13	135	23	7	366a417f9ef7c0d86e9f262d97bf788f478315ee
ToppCell	NS-moderate-d_07-13\|moderate / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	SPRR2A SPRR2B SPRR2D SPRR2E SPRR2F SPRR2G LCE3E	5.96e-12	195	23	7	088209505a68519ec89f50f0576096da6966bf17
ToppCell	NS-moderate-d_07-13-Epithelial-Squamous\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	LCE3D SPRR2A SPRR2B SPRR2D SPRR2E SPRR2F SPRR2G	6.64e-12	198	23	7	b7495369baba203490c067a58fc8456a778a12e4
ToppCell	3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.3\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	LCE3D SPRR2A SPRR2B SPRR2D SPRR2E SPRR2F	3.48e-10	179	23	6	2b5f8e109a67c7fc3ec2b83e8f1854160c99283a
ToppCell	PSB-critical-LOC-Epithelial-Squamous\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	SPRR2A SPRR2B SPRR2D SPRR2E SPRR2F SPRR2G	3.97e-10	183	23	6	2cf798a2371c61322484ea16fdfae0acfa94f102
ToppCell	TCGA-Skin-Primary_Tumor-Melanoma-Skin_Cutaneous_Melanoma-6\|TCGA-Skin / Sample_Type by Project: Shred V9	LCE3D SPRR2A SPRR2B SPRR2E SPRR2G LCE3E	4.53e-10	187	23	6	2ca7928baf0c5e61f7294ed05e6e6f0e0adf9d3f
ToppCell	Smart-seq2-tissue-resident_(Smart-seq2)-myeloid-myeloid_monocytic\|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	SPRR2A SPRR2B SPRR2D SPRR2E SPRR2F SPRR2G	6.01e-10	196	23	6	03de28e1c963e99623e8b0e33bf2e8ef67dc3baa
ToppCell	10x_3'_v3-tissue-resident_(10x_3'_v3)-myeloid-myeloid_monocytic\|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	SPRR2A SPRR2B SPRR2D SPRR2E SPRR2F SPRR2G	6.19e-10	197	23	6	7870c0651caefb0ed13d9f9dab43b5f24d6a9efc
ToppCell	10x_3'_v3-tissue-resident_(10x_3'_v3)-myeloid-myeloid_monocytic-leukocyte\|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	SPRR2A SPRR2B SPRR2D SPRR2E SPRR2F SPRR2G	6.19e-10	197	23	6	d968d7d5608b175bb567ea3a315bf473ec3be459
ToppCell	Smart-seq2-tissue-resident_(Smart-seq2)-myeloid-myeloid_monocytic-leukocyte\|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	SPRR2A SPRR2B SPRR2D SPRR2E SPRR2F SPRR2G	6.19e-10	197	23	6	e621d4f9d4ba5e3ef17d2b477e5e14ea0251147e
ToppCell	TCGA-Breast-Primary_Tumor-Breast_Carcinoma-Metaplastic_Carcinoma-2\|TCGA-Breast / Sample_Type by Project: Shred V9	LCE3D SPRR2D SPRR2G LCE3E LCE3C	1.05e-09	92	23	5	cad8b1b74a412988b2ae4f6126b2186100a2cdc2
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Oligoastrocytoma-2\|TCGA-Brain / Sample_Type by Project: Shred V9	SPRR2A SPRR2B SPRR2D SPRR2E SPRR2G	8.42e-09	139	23	5	6f6c64eaa1ce84e0aa9a0caa9c4d9bf7afe626df
ToppCell	TCGA-Bladder-Primary_Tumor-Urothelial_Carcinoma-Non-Papillary_Muscle_Invasive_Urothelial_Carcinoma-6\|TCGA-Bladder / Sample_Type by Project: Shred V9	SPRR2A SPRR2B SPRR2D SPRR2E SPRR2F	2.38e-08	171	23	5	0e78389f8f3d54570a6deb3dd307b865b46307e9
ToppCell	NS-moderate-d_16-33-Epithelial-Squamous\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	SPRR2A SPRR2B SPRR2D SPRR2E SPRR2F	4.25e-08	192	23	5	103496f428f59683ac3ae6147682c07c30663724
ToppCell	NS-critical-d_07-13-Epithelial-Squamous\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	SPRR2A SPRR2B SPRR2D SPRR2E SPRR2F	4.47e-08	194	23	5	53a34843d529ef395deb27086f71f7049a087bab
ToppCell	critical-Epithelial-Squamous\|critical / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	SPRR2A SPRR2B SPRR2D SPRR2E SPRR2F	4.83e-08	197	23	5	eccc80d6ab79c46b10108de1cff3abeacfc105cd
ToppCell	moderate-Epithelial-Squamous\|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	SPRR2A SPRR2B SPRR2D SPRR2E SPRR2F	4.83e-08	197	23	5	ab3c90a5b643b45d0b83939c6304b11f567c5d78
ToppCell	NS-control-d_0-4-Epithelial-Squamous\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	SPRR2A SPRR2B SPRR2D SPRR2E SPRR2F	4.83e-08	197	23	5	ab965a0ba87efd3329d24a1ec123985f46fc17c0
ToppCell	critical-Epithelial-Squamous\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	SPRR2A SPRR2B SPRR2D SPRR2E SPRR2F	4.83e-08	197	23	5	cfbdaada7169afb68455724ae87032ff311b2d89
ToppCell	moderate-Epithelial-Squamous\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	SPRR2A SPRR2B SPRR2D SPRR2E SPRR2F	4.83e-08	197	23	5	2e13881f917d4f62a5b3e968e41c57e43300d988
ToppCell	TCGA-Breast-Primary_Tumor-Breast_Carcinoma-Metaplastic_Carcinoma\|TCGA-Breast / Sample_Type by Project: Shred V9	LCE3D SPRR2G LCE3E LCE3C	4.93e-08	71	23	4	ab476ee0b91d91d44d4324da18e2e7938bba3d2c
ToppCell	TCGA-Bone_and_Soft_Tissue-Recurrent_Tumor\|TCGA-Bone_and_Soft_Tissue / Sample_Type by Project: Shred V9	SPRR2D LCE2D LCE2C LCE2A	1.41e-07	92	23	4	b728c0faf742c9235b891e3acf34d18a0e335c22
ToppCell	TCGA-Bone_and_Soft_Tissue-Recurrent_Tumor-Sarcoma\|TCGA-Bone_and_Soft_Tissue / Sample_Type by Project: Shred V9	SPRR2D LCE2D LCE2C LCE2A	1.41e-07	92	23	4	207cde9de6f37b33e47bc6f9c32c9877ab7cbe63
ToppCell	TCGA-Breast-Primary_Tumor-Breast_Carcinoma-Ductal_and_Metaplastic_Carcinoma-4\|TCGA-Breast / Sample_Type by Project: Shred V9	SPRR2A SPRR2B SPRR2D SPRR2E	4.52e-07	123	23	4	11802979943a9205f10facda322fc220d4bf7133
ToppCell	TCGA-Breast-Primary_Tumor-Breast_Carcinoma-Ductal_and_Metaplastic_Carcinoma\|TCGA-Breast / Sample_Type by Project: Shred V9	SPRR2A SPRR2B SPRR2D SPRR2E	4.52e-07	123	23	4	51e49a64fbbf77e2ee21f45fd515d43282b11516
ToppCell	TCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-7\|TCGA-Pancreas / Sample_Type by Project: Shred V9	SPRR2A SPRR2D SPRR2E LCE1F	4.67e-07	124	23	4	c6e0c45e9ac128540baddfeb4599a0d5ec3f14cb
ToppCell	Bronchial_Biopsy-Epithelial-Goblet_2\|Bronchial_Biopsy / Tissue, Lineage and Cell class of Lung Cells from 10X	SPRR2A SPRR2D SPRR2E SPRR2F	1.08e-06	153	23	4	b25629953ff79aff645845376132b12023067b01
ToppCell	Bronchial_Biopsy-Epithelial-Goblet_2\|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X	SPRR2A SPRR2D SPRR2E SPRR2F	1.08e-06	153	23	4	e9d6b4e895ddb8d6e6c8b043da591ec11365e124
ToppCell	TCGA-Stomach-Primary_Tumor-Stomach_Adenocarcinoma-Stomach_Adenocarcinoma_-_NOS-4\|TCGA-Stomach / Sample_Type by Project: Shred V9	SPRR2A SPRR2D SPRR2E SPRR2F	1.39e-06	163	23	4	6a12b802cb181f979ebc72674f3626fb855024e3
ToppCell	TCGA-Cervix-Primary_Tumor-Cervical_Carcinoma-Keratinizing_Cervical_Squamous_Cell_Carcinoma\|TCGA-Cervix / Sample_Type by Project: Shred V9	LCE1C LCE3D LCE1F LCE3E	1.43e-06	164	23	4	de1646dbcf2a10b48e021acf7dc63e803e6a47ce
ToppCell	NS-moderate-d_0-4-Epithelial-Squamous\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	SPRR2A SPRR2D SPRR2E SPRR2F	1.61e-06	169	23	4	4a5d023ffcf83312d29b1d215eb6b744ef1a0777
ToppCell	TCGA-Head_and_Esophagus-Primary_Tumor-Head_and_Neck_Carcinoma-Squamous_Cell_Carcinoma-6\|TCGA-Head_and_Esophagus / Sample_Type by Project: Shred V9	LCE3D SPRR2B LCE2D LCE3E	1.65e-06	170	23	4	3dba3f810fbd1eadf446b52e4c9c971d362a80e1
ToppCell	facs-Skin-Skin_Anagen-18m-Epithelial-epidermal_cell\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LCE1B LCE1E LCE1D LCE1F	1.77e-06	173	23	4	0f9c1d3298e59e6d22bb3306f0f445f490be8bbd
ToppCell	NS\|World / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	SPRR2A SPRR2D SPRR2E SPRR2F	2.07e-06	180	23	4	8472dcce7bc0b7ce428ec17ddf0018f3258f78d2
ToppCell	droplet-Tongue-Unstain-18m-Epithelial-suprabasal_interpapillary\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LCE1D LCE3B LCE1F LCE3C	2.07e-06	180	23	4	18bf8561ad3aa9787d2a8ef942a96f641734c608
ToppCell	wk_15-18-Mesenchymal-Mesothelial-Late_mesothelial\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	SPRR2A SPRR2B SPRR2E SPRR2F	2.46e-06	188	23	4	38a53f99f1876359983936403aefca93281d10fd
ToppCell	3'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.2.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	LCE1C SPRR2D SPRR2E SPRR2F	2.67e-06	192	23	4	24fb2f1e6f49ab5b71876e105c0ee7f59e7d64e8
ToppCell	NS-critical-d_0-4-Epithelial-Squamous\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	SPRR2A SPRR2D SPRR2E SPRR2F	2.78e-06	194	23	4	614d0c25b56957c70f397abb169fd2a860eb1c06
ToppCell	NS-critical-d_16-33-Epithelial-Squamous\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	SPRR2A SPRR2D SPRR2E SPRR2F	2.90e-06	196	23	4	97e16d9833e4083d719ca7058d5fc9b11edb37e3
ToppCell	5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SPRR2A SPRR2D SPRR2E SPRR2F	2.96e-06	197	23	4	fb272c9c60ee3d980e528044dc567b4925a23da6
ToppCell	5'-Airway_Nasal-Epithelial-Airway_epithelium\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SPRR2A SPRR2D SPRR2E SPRR2F	2.96e-06	197	23	4	61c0d78b29dc4ad8a84172cbfcdab03f31351d0e
ToppCell	5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SPRR2A SPRR2D SPRR2E SPRR2F	2.96e-06	197	23	4	dcabea5c50c133c9a4e294e447462d0393174ea7
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.2.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SPRR2A SPRR2D SPRR2E SPRR2F	2.96e-06	197	23	4	2430f31d9312338e0ca23bfc6bdb0365340860fd
ToppCell	Biopsy_Control_(H.)-Epithelial-SCGB3A2+\|Biopsy_Control_(H.) / Sample group, Lineage and Cell type	SPRR2A SPRR2D SPRR2E SPRR2G	3.02e-06	198	23	4	1fe51f4beca0eef4ff117e6edaa646e35c0f9629
ToppCell	5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.2.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SPRR2A SPRR2D SPRR2E SPRR2F	3.02e-06	198	23	4	e06d41a7254a09e037ec404be2d8c352d5cbd7f4
ToppCell	control-Epithelial-Squamous\|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	SPRR2A SPRR2D SPRR2E SPRR2F	3.02e-06	198	23	4	6ba669ac1ed275ae309054941b1457e315766faa
ToppCell	(08)_Brush+PNEC\|World / shred by cell type by condition	SPRR2A SPRR2D SPRR2E SPRR2F	3.08e-06	199	23	4	f2e33cb569c25fc2732722cac295647e9bd8738f
ToppCell	control-Epithelial-Squamous\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	SPRR2A SPRR2D SPRR2E SPRR2F	3.08e-06	199	23	4	e13dca7a055cdca53dd6c26c04b2a46d58b419b6
ToppCell	TCGA-Bone_and_Soft_Tissue-Primary_Tumor-Sarcoma-Undifferentiated_Pleomorphic_Sarcoma-4\|TCGA-Bone_and_Soft_Tissue / Sample_Type by Project: Shred V9	SPRR2B SPRR2E SPRR2F	4.09e-05	131	23	3	2ccf679b5035b7b9cdb9a9a660cad90288592187
ToppCell	Ciliated_cells-A-Donor_06\|World / lung cells shred on cell class, cell subclass, sample id	SPRR2E SPRR2F SPRR2G	6.62e-05	154	23	3	3b938e23324f7edb56797b4a76fb96ff588142cf
ToppCell	TCGA-Cervix-Primary_Tumor-Cervical_Carcinoma-Keratinizing_Cervical_Squamous_Cell_Carcinoma-3\|TCGA-Cervix / Sample_Type by Project: Shred V9	LCE3D LCE1A LCE3E	6.88e-05	156	23	3	ffb9249a115ce31f50b99a7a3d40bf48b9d7f2b0
ToppCell	Ciliated_cells-A-Donor_01\|World / lung cells shred on cell class, cell subclass, sample id	SPRR2A SPRR2E SPRR2G	7.84e-05	163	23	3	43194c6127df1ce3d29242f719645de3c11fd7c0
ToppCell	BAL-Mild-Myeloid-MoAM-MoAM5\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SPRR2A SPRR2D SPRR2E	8.27e-05	166	23	3	ac28c8cac1e94be0c47fb862c5809c92cdaa11f3
ToppCell	BAL-Mild-Myeloid-MoAM-MoAM5\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	SPRR2A SPRR2D SPRR2E	8.27e-05	166	23	3	823ec03714884cb860a1260410feac8c536b6d06
ToppCell	Bronchial_Brush-Epithelial-Goblet_2\|Bronchial_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X	SPRR2A SPRR2E SPRR2F	8.27e-05	166	23	3	8ac0a769be886d16642e7e6334471ebadd1a426b
ToppCell	BAL-Mild-Myeloid-MoAM-MoAM5-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SPRR2A SPRR2D SPRR2E	8.27e-05	166	23	3	006ced12f69ef13ddcba5a3891ddc7c18c384863
ToppCell	BAL-Mild-Myeloid-MoAM-MoAM5-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	SPRR2A SPRR2D SPRR2E	8.27e-05	166	23	3	6bb3410e65c971acc458c472015afcec6de6e310
ToppCell	Bronchial_Brush-Epithelial-Goblet_2\|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X	SPRR2A SPRR2E SPRR2F	8.42e-05	167	23	3	806d1c00c137da0c5f042adf866873eb6dd4bb27
ToppCell	normal_Lung-Fibroblasts-Mesothelial_cells\|Fibroblasts / Location, Cell class and cell subclass	SPRR2B SPRR2D SPRR2F	8.42e-05	167	23	3	892a2dc83ab5de5a1016402f8e95d2aabf651326
ToppCell	3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.3\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SPRR2A SPRR2B SPRR2F	8.88e-05	170	23	3	13a225e32132e9717debb0d64d7c28ada974c3e6
ToppCell	droplet-Tongue-nan-24m-Epithelial-suprabasal_interpapillary\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPRR2D SPRR2F SPRR2G	9.19e-05	172	23	3	6ece9bb9f31685c918ca4cb7b82cf6ad1cad48af
ToppCell	TCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Squamous_Cell_Carcinoma-5\|TCGA-Lung / Sample_Type by Project: Shred V9	SPRR2A SPRR2D SPRR2E	1.00e-04	177	23	3	a0c7d08469c513cecf87777c19876884f1511570
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	LCE1E SPRR2A SPRR2D	1.09e-04	182	23	3	007fa56ed8b91f9af0df2114c00410b2f6cec8b6
ToppCell	tumor_Lung-Fibroblasts-Mesothelial_cells\|tumor_Lung / Location, Cell class and cell subclass	SPRR2A SPRR2B SPRR2F	1.12e-04	184	23	3	b0a251030d127858e68cf164be158f209a4d720f
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.3\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SPRR2A SPRR2D SPRR2E	1.14e-04	185	23	3	f3fbc3096f85397a959cee17c3c4fcf2d511f3d5
ToppCell	TCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Squamous_Cell_Carcinoma\|TCGA-Lung / Sample_Type by Project: Shred V9	SPRR2A SPRR2D SPRR2E	1.21e-04	189	23	3	aa4f7d7a5196e5ae481ebc2549de8e3f0ef6e6be
ToppCell	tumor_Lung-Fibroblasts-Mesothelial_cells\|Fibroblasts / Location, Cell class and cell subclass	SPRR2A SPRR2B SPRR2F	1.23e-04	190	23	3	d82ab67735c1f365d4b0e02b5fa91c64cdc234da
ToppCell	BL-critical-LOC-Epithelial-Squamous\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	SPRR2A SPRR2D SPRR2E	1.25e-04	191	23	3	3f9b8c4fb72ae6f3167b187e6715c4dcb3159f98
ToppCell	5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.3\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SPRR2A SPRR2D SPRR2E	1.25e-04	191	23	3	fbd8d337b4444fba8527a614e4a8bfb516ce0f66
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(nasal)-Club_(nasal)_L.0.2.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SPRR2A SPRR2D SPRR2F	1.25e-04	191	23	3	529068029fb461df766135576dd0d8b5980f9bc0
ToppCell	wk_15-18-Mesenchymal-Mesothelial\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	SPRR2B SPRR2E SPRR2F	1.25e-04	191	23	3	b5374674312ff5803a1d369f5533027532344679
ToppCell	droplet-Tongue-Unstain-18m-Epithelial-suprabasal\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPRR2B SPRR2G LCE3C	1.29e-04	193	23	3	f074ebf9c5c53d8589d66b0109505f30baa1af81
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Epithelial-Epithelial,_Airway-squamous_epithelial_cell\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	SPRR2A SPRR2D SPRR2E	1.33e-04	195	23	3	82d87fdb39ec15be9057e2d2ba5c1afb5f97aafe
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Epithelial-Epithelial,_Airway-squamous_epithelial_cell-Epi-Squamous\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	SPRR2A SPRR2D SPRR2E	1.33e-04	195	23	3	dd8117dbd22892288f74a7314ab0b5080106936c
ToppCell	NS-critical-LOC-Epithelial-Squamous\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	SPRR2A SPRR2D SPRR2E	1.35e-04	196	23	3	453c809494ceffa2a28af283c4b5a4924fcf160f
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Epithelial-Epithelial,_Airway\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	SPRR2A SPRR2D SPRR2E	1.37e-04	197	23	3	ac9c0c25cfeaabd53d332982c73fc6c47b0c6478
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Epithelial\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	SPRR2A SPRR2D SPRR2E	1.37e-04	197	23	3	b57d2e3413ef6dd1da56c45087926f2f3eab876c
ToppCell	medial-Epithelial-Club\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	SPRR2D SPRR2F SPRR2G	1.39e-04	198	23	3	a861cf5bb1950ed5f0363b8a834a1c246e151389
ToppCell	Lung_Parenchyma-Control-Epithelial-Epithelial-Basal_2\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	SPRR2A SPRR2D SPRR2F	1.39e-04	198	23	3	34997e3896d0893fbe51bfb0d4660ccaca1c975e
ToppCell	Parenchyma_Control_(B.)-Epithelial-TX-Basal_2\|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type	SPRR2A SPRR2D SPRR2F	1.39e-04	198	23	3	686eda427b075e788de38149eae82faf19bd5704
ToppCell	distal-2-Epithelial-Club\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	SPRR2D SPRR2F SPRR2G	1.39e-04	198	23	3	3055c03896fbfac82a3072e51c0c54d68131cf1a
ToppCell	medial-2-Epithelial-Club\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	SPRR2D SPRR2F SPRR2G	1.39e-04	198	23	3	7f59d949190c10af13cbd13f81a795483deb9d14
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.2.4\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SPRR2A SPRR2D SPRR2F	1.39e-04	198	23	3	77517df37dc894c78ef1e2b24dd7ba31f928bdb7
ToppCell	medial-Epithelial-Club-2\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	SPRR2D SPRR2F SPRR2G	1.39e-04	198	23	3	da7881351a71cde926325ab3e22d772f64cfab80
ToppCell	Lung_Parenchyma-Control-Epithelial-Epithelial-Basal_2-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SPRR2A SPRR2D SPRR2F	1.39e-04	198	23	3	a54ae5275a510b49d7629f0908817a0c5f05020e
ToppCell	367C\|World / Donor, Lineage, Cell class and subclass (all cells)	SPRR2A SPRR2D SPRR2E	1.39e-04	198	23	3	ab3a178f392204e2d90eb5a3b5de7849986b1eaf
ToppCell	Smart-seq2-tissue-resident_(Smart-seq2)\|Smart-seq2 / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	SPRR2A SPRR2D SPRR2E	1.41e-04	199	23	3	8be7cb9d8b4f9707efb69c681c40e683fcd810e5
ToppCell	Biopsy_Other_PF-Epithelial-SCGB3A2+_SCGB1A1+\|Biopsy_Other_PF / Sample group, Lineage and Cell type	SPRR2A SPRR2D SPRR2F	1.41e-04	199	23	3	036244251d2dd39f8184b7095418c723c0524eff
ToppCell	Bronchus_Control_(B.)-Epithelial-TX-Basal_2\|Bronchus_Control_(B.) / Sample group, Lineage and Cell type	SPRR2A SPRR2D SPRR2F	1.44e-04	200	23	3	0fa3340d945f00ef55c7603476d51bd8346e82c2
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L5_IT-L5_IT_VISp_Col27a1\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	SPRR2G LCE1F	2.23e-04	43	23	2	52772889cdf2e47f703f1d6418da3dc9e5f7d933
ToppCell	TCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Ductal_Adenocarcinoma\|TCGA-Prostate / Sample_Type by Project: Shred V9	LCE3C LCE5A	1.13e-03	97	23	2	a5865817e66924917e6420d26cbc68ac0f9d5f22
ToppCell	TCGA-Kidney-Primary_Tumor-Renal_Cell_Carcinoma-Kidney_Clear_Cell_Renal_Carcinoma-7\|TCGA-Kidney / Sample_Type by Project: Shred V9	LCE1C LCE1E	1.13e-03	97	23	2	88ac93868312c9b57a1b23edc76b5907847d2c1d
ToppCell	TCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Basaloid_Squamous_Cell_Carcinoma\|TCGA-Lung / Sample_Type by Project: Shred V9	LCE1E LCE5A	1.35e-03	106	23	2	af3ac319e65f19f2f690a7e9db434c552893c5f1
ToppCell	TCGA-Endometrium-Primary_Tumor-Endometrial_Adenocarcinoma-Mixed_Serous_and_Endometrioid-6\|TCGA-Endometrium / Sample_Type by Project: Shred V9	LCE2C LCE2A	1.48e-03	111	23	2	5129c4a5004e16f9504300a5bd5f3d76c93a28fe
Computational	Genes upregulated in subsets of cells of a given type within various tumors	SPRR2A SPRR2D	1.26e-04	50	4	2	GAVISH_3CA_MALIGNANT_METAPROGRAM_19_EPITHELIAL_SENESCENCE
Drug	beta-damascenone	LCE1C LCE1B LCE1D LCE1F	6.86e-09	24	22	4	ctd:C075388
Drug	4-tert-octylphenol	SPRR2A SPRR2B SPRR2D SPRR2E SPRR2F SPRR2G	7.18e-09	159	22	6	ctd:C105260
Drug	NSC19448	SPRR2B SPRR2D SPRR2E SPRR2F	1.25e-04	273	22	4	CID000003054
Drug	Mustard Gas	LCE3D LCE1B LCE1D SPRR2A LCE1A SPRR2D SPRR2F	1.88e-04	1341	22	7	ctd:D009151
Drug	Diethylstilbestrol	SPRR2A SPRR2B SPRR2D SPRR2E SPRR2F SPRR2G	1.18e-03	1305	22	6	ctd:D004054
Disease	vitamin D measurement	LCE1C LCE3D LCE1B LCE1A SPRR2F SPRR2G LCE3E LCE5A	2.91e-11	336	20	8	EFO_0004631
Disease	atopic eczema	LCE1C LCE1E LCE1D LCE1F LCE3E LCE5A	1.28e-08	252	20	6	EFO_0000274
Disease	psoriasis, COVID-19	LCE2A LCE2B	4.36e-07	2	20	2	EFO_0000676, MONDO_0100096
Disease	childhood onset asthma	LCE1C LCE1D SPRR2F SPRR5 LCE5A	2.43e-06	334	20	5	MONDO_0005405
Disease	Psoriasis	LCE3D LCE3B LCE3C	7.61e-06	57	20	3	C0033860
Disease	Pustulosis of Palms and Soles	LCE3D LCE3B LCE3C	7.61e-06	57	20	3	C0030246
Disease	level of C-X-C motif chemokine 2 in blood serum	SPRR2E SPRR2F	2.87e-05	12	20	2	OBA_2041207
Disease	level of C-X-C motif chemokine 3 in blood serum	SPRR2E SPRR2F	4.56e-05	15	20	2	OBA_2041208
Disease	asthma	LCE1C LCE1D LCE3E SPRR5 LCE5A	1.19e-04	751	20	5	MONDO_0004979
Disease	hair morphology	LCE3E LCE5A	1.75e-04	29	20	2	EFO_0005038
Disease	atopic asthma	LCE1C LCE1D LCE5A	3.16e-04	199	20	3	EFO_0010638
Disease	psoriasis	LCE3D LCE3B LCE3E	7.95e-04	273	20	3	EFO_0000676
Disease	allergic disease, age at onset	SPRR2B SPRR2E	1.05e-03	71	20	2	EFO_0004847, MONDO_0005271
Disease	allergic disease	SPRR2B SPRR2E	1.30e-02	258	20	2	MONDO_0005271

Protein segments in the cluster

Peptide	Gene	Start	Entry
QPPPKCTPKCPPKCP	LCE1A	11	Q5T7P2
CTPKCPPKCPTPKCP	LCE1A	16	Q5T7P2
PPKCPTPKCPPKCPP	LCE1A	21	Q5T7P2
TPKCPPKCPPKCPPV	LCE1A	26	Q5T7P2
QPPPKCIPKCPPKCL	LCE1B	11	Q5T7P3
PPKCLTPRCPPKCPP	LCE1B	21	Q5T7P3
TPRCPPKCPPKCPPV	LCE1B	26	Q5T7P3
QPPPKCTPKCPPKCP	LCE1C	11	Q5T751
CTPKCPPKCPTPKCP	LCE1C	16	Q5T751
PPKCPTPKCPPKCPP	LCE1C	21	Q5T751
TPKCPPKCPPKCPPV	LCE1C	26	Q5T751
QPPPKCTPKCTPKCP	LCE1D	11	Q5T752
TPKCPAPKCPPKCPP	LCE1D	21	Q5T752
QPPPKCTPKCPPKCP	LCE1E	11	Q5T753
CTPKCPPKCPTPKCP	LCE1E	16	Q5T753
PPKCPTPKCPPKCPP	LCE1E	21	Q5T753
TPKCPPKCPPKCPPV	LCE1E	26	Q5T753
QPPPKCTPKCPPKCP	LCE1F	11	Q5T754
CTPKCPPKCPTPKCP	LCE1F	16	Q5T754
PPKCPTPKCPPKCPP	LCE1F	21	Q5T754
TPKCPPKCPPKCPPV	LCE1F	26	Q5T754
QPPPKCPPKCPPKCP	LCE2A	11	Q5TA79
CPPKCPPKCPPKCRP	LCE2A	16	Q5TA79
PPKCPPKCRPQCPAP	LCE2A	21	Q5TA79
QPPPKCPPKCTPKCP	LCE2B	11	O14633
CPPKCTPKCPPKCPP	LCE2B	16	O14633
TPKCPPKCPPKCLPQ	LCE2B	21	O14633
PKCPPKCLPQCPAPC	LCE2B	26	O14633
QPPPKCPPKCTPKCP	LCE2C	11	Q5TA81
CPPKCTPKCPPKCPP	LCE2C	16	Q5TA81
TPKCPPKCPPKCPPQ	LCE2C	21	Q5TA81
PKCPPKCPPQCPAPC	LCE2C	26	Q5TA81
QPPPKCPPKCTPKCP	LCE2D	11	Q5TA82
CPPKCTPKCPPKCPP	LCE2D	16	Q5TA82
TPKCPPKCPPKCPPQ	LCE2D	21	Q5TA82
PKCPPKCPPQCPAPC	LCE2D	26	Q5TA82
QPLPKCPSPKCPPKS	LCE3B	11	Q5TA77
QPPPSCPSPKCPPKS	LCE3C	11	Q5T5A8
QPPPKCPSPKCPPKS	LCE3D	11	Q9BYE3
QPPPKCPSPKCPPKN	LCE3E	11	Q5T5B0
QPPPKCPIPKYPPKC	LCE4A	11	Q5TA78
QPPPKCTPKCPPKCT	LCE5A	11	Q5TCM9
CTPKCPPKCTPKCPP	LCE5A	16	Q5TCM9
PPKCTPKCPPKCPPK	LCE5A	21	Q5TCM9
PKCPPKCPPKCPPQC	LCE5A	26	Q5TCM9
PCQPPPKCQEPCAPK	SPRR5	81	A0A1B0GTR4
PKCQEPCAPKCPPPQ	SPRR5	86	A0A1B0GTR4
PCQPPPVCPTPKCPE	SPRR2A	11	P35326
PKCPEPCPPPKCPEP	SPRR2A	21	P35326
PCPPPKCPEPCPPPK	SPRR2A	26	P35326
KCPEPCPPPKCPQPC	SPRR2A	31	P35326
CPPPKCPQPCPPQQC	SPRR2A	36	P35326
PCQPPPVCPTPKCPE	SPRR2B	11	P35325
PKCPEPCPPPKCPEP	SPRR2B	21	P35325
PCPPPKCPEPCPPPK	SPRR2B	26	P35325
KCPEPCPPPKCPQPC	SPRR2B	31	P35325
CPPPKCPQPCPPQQC	SPRR2B	36	P35325
PCQPPPVCPTPKCPE	SPRR2D	11	P22532
PKCPEPCPPPKCPEP	SPRR2D	21	P22532
PCPPPKCPEPCPSPK	SPRR2D	26	P22532
PVTPSPPCQPKCPPK	SPRR2D	56	P22532
PCQPPPVCPTPKCPE	SPRR2E	11	P22531
PKCPEPCPPPKCPEP	SPRR2E	21	P22531
PCPPPKCPEPCPPPK	SPRR2E	26	P22531
KCPEPCPPPKCPQPC	SPRR2E	31	P22531
CPPPKCPQPCPPQQC	SPRR2E	36	P22531
PVTPSPPCQPKCPPK	SPRR2E	56	P22531
PCQPPPVCPAPKCPE	SPRR2F	11	Q96RM1
PKCPEPCPPPKCPEP	SPRR2F	21	Q96RM1
PCPPPKCPEPCPPSK	SPRR2F	26	Q96RM1
PVTPSPPCQPKCPPK	SPRR2F	56	Q96RM1
PCQPPPVCPTPKCPE	SPRR2G	11	Q9BYE4
PKCPEPCPPPKCPEP	SPRR2G	21	Q9BYE4
CPPPPCQDKCPPVQP	SPRR2G	46	Q9BYE4