Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiondisordered domain specific binding

NCOA3 HSP90AB4P CTNNB1 HSP90AA1 HSP90AA4P HSP90AA2P HSP90AB1

5.16e-09391297GO:0097718
GeneOntologyMolecularFunctionATP-dependent protein folding chaperone

HSP90AB4P HSP90AA1 HSP90AA4P HSP90AA2P HSP90AB1

5.71e-06401295GO:0140662
GeneOntologyMolecularFunctionATP hydrolysis activity

DHX36 HSP90AB4P KIF1A MYO5B DHX9 ATAD3B ATAD3C DHX34 TAP1 HSP90AA1 HSP90AA4P HSP90AA2P HSP90AB1

5.75e-0644112913GO:0016887
GeneOntologyMolecularFunctionCTP binding

HSP90AA1 HSP90AB1

4.14e-0521292GO:0002135
GeneOntologyMolecularFunctionATP-dependent activity

DHX36 HSP90AB4P KIF1A MYO5B KIF26B DHX9 ATAD3B ATAD3C DHX34 TAP1 HSP90AA1 HSP90AA4P HSP90AA2P HSP90AB1

4.40e-0561412914GO:0140657
GeneOntologyMolecularFunctionaspartic-type endopeptidase activity

ERVK-7 ERVK-21 ERVK-18 ERVK-24

9.31e-05371294GO:0004190
GeneOntologyMolecularFunctionaspartic-type peptidase activity

ERVK-7 ERVK-21 ERVK-18 ERVK-24

1.04e-04381294GO:0070001
GeneOntologyMolecularFunctionprotein folding chaperone

HSP90AB4P HSP90AA1 HSP90AA4P HSP90AA2P HSP90AB1

1.10e-04731295GO:0044183
GeneOntologyMolecularFunctionendopeptidase activity

PAPPA2 TPP2 ADAM18 ERVK-7 ERVK-21 F3 CD5L ERVK-18 ERVK-24 MMP26 CTSB

1.11e-0443012911GO:0004175
GeneOntologyMolecularFunctionsulfonylurea receptor binding

HSP90AA1 HSP90AB1

1.24e-0431292GO:0017098
GeneOntologyMolecularFunctionUTP binding

HSP90AA1 HSP90AB1

2.46e-0441292GO:0002134
GeneOntologyMolecularFunctionpyrimidine ribonucleotide binding

HSP90AA1 HSP90AB1

4.09e-0451292GO:0032557
GeneOntologyMolecularFunctiondATP binding

HSP90AA1 HSP90AB1

4.09e-0451292GO:0032564
GeneOntologyMolecularFunctioncytoskeleton-nuclear membrane anchor activity

SYNE1 SYNE2

4.09e-0451292GO:0140444
GeneOntologyMolecularFunctionribonucleoside triphosphate phosphatase activity

DHX36 HSP90AB4P KIF1A MYO5B DHX9 ARHGAP5 ATAD3B ATAD3C DHX34 TAP1 HSP90AA1 HSP90AA4P HSP90AA2P HSP90AB1

4.92e-0477512914GO:0017111
GeneOntologyMolecularFunctionadenyl deoxyribonucleotide binding

HSP90AA1 HSP90AB1

6.11e-0461292GO:0032558
GeneOntologyMolecularFunctionnuclear receptor coactivator activity

NCOA3 SMARCD3 MED17 MED12

6.53e-04611294GO:0030374
GeneOntologyMolecularFunctionactin filament binding

MYO5B SYNE1 SPTAN1 SPTBN1 ESPNL POF1B IQGAP3

6.92e-042271297GO:0051015
GeneOntologyMolecularFunctiontranscription coactivator activity

NCOA3 DHX9 YAP1 SMARCD3 CTNNB1 MED17 MED27 MED12

8.00e-043031298GO:0003713
GeneOntologyMolecularFunctionC-X-C chemokine binding

CXCR6 ACKR3

8.51e-0471292GO:0019958
GeneOntologyMolecularFunctionpurine deoxyribonucleotide binding

HSP90AA1 HSP90AB1

8.51e-0471292GO:0032554
GeneOntologyMolecularFunctionpyrophosphatase activity

DHX36 HSP90AB4P KIF1A MYO5B DHX9 ARHGAP5 ATAD3B ATAD3C DHX34 TAP1 HSP90AA1 HSP90AA4P HSP90AA2P HSP90AB1

1.06e-0383912914GO:0016462
GeneOntologyMolecularFunctionhydrolase activity, acting on acid anhydrides

DHX36 HSP90AB4P KIF1A MYO5B DHX9 ARHGAP5 ATAD3B ATAD3C DHX34 TAP1 HSP90AA1 HSP90AA4P HSP90AA2P HSP90AB1

1.08e-0384012914GO:0016817
GeneOntologyMolecularFunctionhydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

DHX36 HSP90AB4P KIF1A MYO5B DHX9 ARHGAP5 ATAD3B ATAD3C DHX34 TAP1 HSP90AA1 HSP90AA4P HSP90AA2P HSP90AB1

1.08e-0384012914GO:0016818
GeneOntologyMolecularFunctionpeptidase activity

PAPPA2 TPP2 RELN ADAM18 ERVK-7 ERVK-21 F3 CD5L ERVK-18 ERVK-24 MMP26 CTSB

1.10e-0365412912GO:0008233
GeneOntologyMolecularFunctionactin binding

KLHL2 MYO5B SYNE1 SPTAN1 SPTBN1 ESPNL POF1B SYNE2 PALLD IQGAP3

1.11e-0347912910GO:0003779
GeneOntologyMolecularFunctionTPR domain binding

HSP90AA1 HSP90AB1

1.13e-0381292GO:0030911
GeneOntologyMolecularFunctionC-X-C chemokine receptor activity

CXCR6 ACKR3

1.13e-0381292GO:0016494
GeneOntologyMolecularFunctionnuclear thyroid hormone receptor binding

NCOA3 MED17 MED12

1.36e-03341293GO:0046966
GeneOntologyMolecularFunctionunfolded protein binding

HSP90AB4P HSP90AA1 HSP90AA4P HSP90AA2P HSP90AB1

1.36e-031261295GO:0051082
GeneOntologyMolecularFunctionnuclear receptor binding

NCOA3 STAT3 SMARCD3 CTNNB1 MED17 MED12

1.37e-031871296GO:0016922
GeneOntologyMolecularFunctiondeoxyribonucleotide binding

HSP90AA1 HSP90AB1

1.45e-0391292GO:0032552
GeneOntologyMolecularFunctionnitric-oxide synthase regulator activity

HSP90AA1 HSP90AB1

1.80e-03101292GO:0030235
GeneOntologyMolecularFunctioncytoskeletal protein binding

KLHL2 KIF1A MYO5B KIF26B SYNE1 SPTAN1 SPTBN1 ESPNL NEDD1 POF1B ALMS1 SYNE2 PALLD IQGAP3 HSP90AA1 HSP90AB1

1.94e-03109912916GO:0008092
GeneOntologyMolecularFunctionRNA-DNA hybrid ribonuclease activity

ERVK-7 EXO1

2.19e-03111292GO:0004523
GeneOntologyMolecularFunctionpyrimidine nucleotide binding

HSP90AA1 HSP90AB1

2.19e-03111292GO:0019103
GeneOntologyMolecularFunctionaxon guidance receptor activity

ROBO2 PALLD

3.08e-03131292GO:0008046
GeneOntologyMolecularFunctioncytokine receptor activity

F3 CXCR6 ACKR3 IL6ST

3.62e-03971294GO:0004896
GeneOntologyBiologicalProcesscellular response to heat

DHX36 HSP90AB4P DHX9 HSP90AA1 HSP90AA4P HSP90AA2P HSP90AB1

7.93e-07811307GO:0034605
GeneOntologyBiologicalProcessresponse to heat

DHX36 HSP90AB4P DHX9 HSP90AA1 HSP90AA4P HSP90AA2P HSP90AB1

1.17e-051211307GO:0009408
GeneOntologyBiologicalProcesscerebral cortex radial glia-guided migration

RELN SYNE2 ULK4 CTNNB1

3.64e-05301304GO:0021801
GeneOntologyBiologicalProcesstelencephalon glial cell migration

RELN SYNE2 ULK4 CTNNB1

3.64e-05301304GO:0022030
GeneOntologyBiologicalProcessregulation of neurogenesis

ZCCHC24 DHX36 RELN MYO5B NTF3 DYNLT1 KIAA0319 YAP1 ROBO2 SMARCD3 CTNNB1 IL6ST

1.03e-0451513012GO:0050767
GeneOntologyBiologicalProcessglial cell fate determination

NTF3 CTNNB1

1.18e-0431302GO:0007403
GeneOntologyBiologicalProcessstem cell population maintenance

NCOA3 MCPH1 STAT3 YAP1 CTNNB1 MED17 MED27 MED12

1.32e-042371308GO:0019827
GeneOntologyBiologicalProcesscerebral cortex radially oriented cell migration

RELN SYNE2 ULK4 CTNNB1

1.40e-04421304GO:0021799
GeneOntologyBiologicalProcessmaintenance of cell number

NCOA3 MCPH1 STAT3 YAP1 CTNNB1 MED17 MED27 MED12

1.52e-042421308GO:0098727
GeneOntologyBiologicalProcesslayer formation in cerebral cortex

RELN ULK4 CTNNB1

1.56e-04171303GO:0021819
GeneOntologyBiologicalProcessregulation of nervous system development

ZCCHC24 DHX36 RELN MYO5B NTF3 DYNLT1 KIAA0319 YAP1 IQSEC1 ROBO2 SMARCD3 CTNNB1 IL6ST

1.63e-0462513013GO:0051960
GeneOntologyBiologicalProcesscellular response to interleukin-6

SELP STAT3 YAP1 IL6ST

1.84e-04451304GO:0071354
GeneOntologyBiologicalProcessprotein ubiquitination

TPP2 KLHL2 FBXW12 WWP1 ZZEF1 TULP4 DCAF10 KLHL42 CTNNB1 MED17 MED27 HECTD1 MED12 HSP90AA1 HSP90AB1

1.84e-0481113015GO:0016567
GeneOntologyBiologicalProcessmating plug formation

SEMG2 TGM4

2.35e-0441302GO:0042628
GeneOntologyBiologicalProcessresponse to interleukin-6

SELP STAT3 YAP1 IL6ST

2.56e-04491304GO:0070741
GeneOntologyBiologicalProcessdendritic spine development

DHX36 RELN KIF1A MYO5B IQSEC1 ULK4

2.73e-041411306GO:0060996
GeneOntologyBiologicalProcessdendrite development

DHX36 RELN KIF1A MYO5B SYNE1 DYNLT1 KIAA0319 IQSEC1 ULK4

2.78e-043351309GO:0016358
GeneOntologyCellularComponentficolin-1-rich granule lumen

PSMA5 DYNLT1 AGL PYGL CTSB HSP90AA1 HSP90AB1

1.14e-051241287GO:1904813
GeneOntologyCellularComponentficolin-1-rich granule

PSMA5 DYNLT1 ATAD3B AGL PYGL CTSB HSP90AA1 HSP90AB1

1.87e-051851288GO:0101002
GeneOntologyCellularComponentcell surface

SELP NID2 BTNL8 CUBN ZZEF1 F3 FCRL3 CD5L CXCR6 ACKR3 PKD1 ROBO2 LY75 CTSB IL6ST HSP90AA1 CLEC2B IGSF3 HSP90AB1

4.63e-05111112819GO:0009986
GeneOntologyCellularComponentmicrovillus membrane

CUBN FCRL3 CTNNB1 MUC4

8.43e-05381284GO:0031528
GeneOntologyCellularComponentaxonal growth cone

DYNLT1 PALLD HSP90AA1 HSP90AB1

1.65e-04451284GO:0044295
GeneOntologyCellularComponentcell projection membrane

SPTBN1 CUBN FCRL3 SYNE2 PKD1 ROBO2 CTNNB1 MUC4 HSP90AA1 HSP90AB1

3.26e-0443112810GO:0031253
GeneOntologyCellularComponentexternal side of plasma membrane

SELP BTNL8 CUBN F3 FCRL3 CXCR6 ACKR3 LY75 CTSB IL6ST CLEC2B

3.54e-0451912811GO:0009897
GeneOntologyCellularComponentsecretory granule lumen

SPTAN1 PSMA5 DYNLT1 DBH AGL PYGL HSP90AA1 HSP90AB1

8.91e-043251288GO:0034774
GeneOntologyCellularComponentcytoplasmic vesicle lumen

SPTAN1 PSMA5 DYNLT1 DBH AGL PYGL HSP90AA1 HSP90AB1

9.83e-043301288GO:0060205
GeneOntologyCellularComponentvesicle lumen

SPTAN1 PSMA5 DYNLT1 DBH AGL PYGL HSP90AA1 HSP90AB1

1.02e-033321288GO:0031983
GeneOntologyCellularComponentspectrin

SPTAN1 SPTBN1

1.30e-0391282GO:0008091
GeneOntologyCellularComponentsecretory granule

SELP SEMG2 KIF1A SPTAN1 PSMA5 DYNLT1 DBH ATAD3B AGL PYGL CALCRL CTSB VPS13B HSP90AA1 HSP90AB1

1.37e-03101412815GO:0030141
GeneOntologyCellularComponentmediator complex

MED17 MED27 MED12

1.50e-03371283GO:0016592
GeneOntologyCellularComponentsecretory vesicle

SELP SEMG2 KIF1A NTF3 SPTAN1 PSMA5 DYNLT1 DBH ATAD3B AGL IQSEC1 PYGL CALCRL CTSB VPS13B HSP90AA1 HSP90AB1

1.57e-03124612817GO:0099503
GeneOntologyCellularComponentactin-based cell projection

ESPNL CUBN FCRL3 SYNE2 CTNNB1 MUC4 PALLD

1.64e-032781287GO:0098858
GeneOntologyCellularComponentnuclear membrane protein complex

SYNE1 SYNE2

1.97e-03111282GO:0106083
GeneOntologyCellularComponentnuclear membrane microtubule tethering complex

SYNE1 SYNE2

1.97e-03111282GO:0106094
GeneOntologyCellularComponentmicrotubule organizing center attachment site

SYNE1 SYNE2

1.97e-03111282GO:0034992
GeneOntologyCellularComponentmeiotic nuclear membrane microtubule tethering complex

SYNE1 SYNE2

1.97e-03111282GO:0034993
GeneOntologyCellularComponentmain axon

SPTAN1 SPTBN1 DBH ROBO2

2.19e-03891284GO:0044304
GeneOntologyCellularComponentlateral plasma membrane

SPTAN1 PKD1 CTNNB1 IQGAP3

2.28e-03901284GO:0016328
GeneOntologyCellularComponentdendritic growth cone

HSP90AA1 HSP90AB1

2.36e-03121282GO:0044294
GeneOntologyCellularComponentcuticular plate

SPTAN1 SPTBN1

2.78e-03131282GO:0032437
GeneOntologyCellularComponentfascia adherens

SPTAN1 CTNNB1

2.78e-03131282GO:0005916
DomainSpectrin

SYNE1 SPTAN1 SPTBN1 SYNE2

1.39e-05231224PF00435
DomainSpectrin_repeat

SYNE1 SPTAN1 SPTBN1 SYNE2

3.63e-05291224IPR002017
DomainSPEC

SYNE1 SPTAN1 SPTBN1 SYNE2

5.41e-05321224SM00150
DomainSpectrin/alpha-actinin

SYNE1 SPTAN1 SPTBN1 SYNE2

5.41e-05321224IPR018159
DomainDUF3523

ATAD3B ATAD3C

1.26e-0431222IPR021911
DomainHeat_shock_protein_90_CS

HSP90AA1 HSP90AB1

1.26e-0431222IPR019805
DomainDUF3523

ATAD3B ATAD3C

1.26e-0431222PF12037
DomainDUF1605

DHX36 DHX9 DHX34

1.73e-04171223IPR011709
DomainOB_NTP_bind

DHX36 DHX9 DHX34

1.73e-04171223PF07717
DomainHA2

DHX36 DHX9 DHX34

2.07e-04181223SM00847
DomainHA2

DHX36 DHX9 DHX34

2.07e-04181223PF04408
DomainHelicase-assoc_dom

DHX36 DHX9 DHX34

2.07e-04181223IPR007502
DomainKASH

SYNE1 SYNE2

2.52e-0441222IPR012315
DomainHsp90_fam

HSP90AA1 HSP90AB1

2.52e-0441222IPR001404
DomainHsp90_N

HSP90AA1 HSP90AB1

2.52e-0441222IPR020575
DomainKASH

SYNE1 SYNE2

2.52e-0441222PS51049
DomainHSP90

HSP90AA1 HSP90AB1

2.52e-0441222PF00183
DomainKASH

SYNE1 SYNE2

2.52e-0441222SM01249
DomainHSP90

HSP90AA1 HSP90AB1

2.52e-0441222PS00298
DomainKASH

SYNE1 SYNE2

2.52e-0441222PF10541
DomainNIDO_dom

NID2 MUC4

4.18e-0451222IPR003886
DomainNIDO

NID2 MUC4

4.18e-0451222SM00539
DomainNIDO

NID2 MUC4

4.18e-0451222PF06119
DomainNIDO

NID2 MUC4

4.18e-0451222PS51220
DomainACTININ_2

SYNE1 SPTBN1 SYNE2

4.38e-04231223PS00020
DomainACTININ_1

SYNE1 SPTBN1 SYNE2

4.38e-04231223PS00019
DomainActinin_actin-bd_CS

SYNE1 SPTBN1 SYNE2

4.38e-04231223IPR001589
DomainFN3_dom

PAPPA2 F3 KIAA0319 FNDC7 ROBO2 FNDC8 IL6ST

4.49e-042091227IPR003961
DomainPKD/REJ-like

KIAA0319 PKD1

6.24e-0461222IPR002859
DomainREJ

KIAA0319 PKD1

6.24e-0461222PF02010
DomainIg-like_fold

PAPPA2 BTNL8 NXPE1 F3 KIAA0319 TGM4 FNDC7 FCRL3 ROBO2 FNDC8 PALLD IL6ST IGSF3

7.18e-0470612213IPR013783
DomainCH

SYNE1 SPTBN1 SYNE2 IQGAP3

8.63e-04651224SM00033
DomainEGF_3

SELP NID2 RELN ADAM18 CUBN MALRD1 MUC4

8.98e-042351227PS50026
DomainCH

SYNE1 SPTBN1 SYNE2 IQGAP3

1.14e-03701224PF00307
DomainNeurexophilin

NXPH1 NXPE1

1.15e-0381222PF06312
DomainNXPH/NXPE

NXPH1 NXPE1

1.15e-0381222IPR026845
Domain-

SYNE1 SPTBN1 SYNE2 IQGAP3

1.20e-037112241.10.418.10
DomainEGF-like_dom

SELP NID2 RELN ADAM18 CUBN MALRD1 MUC4

1.26e-032491227IPR000742
DomainCH

SYNE1 SPTBN1 SYNE2 IQGAP3

1.33e-03731224PS50021
Domain-

PAPPA2 BTNL8 NXPE1 F3 TGM4 FNDC7 FCRL3 ROBO2 FNDC8 PALLD IL6ST IGSF3

1.34e-03663122122.60.40.10
DomainFN3

PAPPA2 KIAA0319 FNDC7 ROBO2 FNDC8 IL6ST

1.36e-031851226SM00060
DomainEGF

SELP NID2 CUBN MALRD1 MUC4

1.43e-031261225PF00008
DomainCH-domain

SYNE1 SPTBN1 SYNE2 IQGAP3

1.47e-03751224IPR001715
DomainPKD/Chitinase_dom

KIAA0319 PKD1

1.48e-0391222IPR022409
DomainPKD

KIAA0319 PKD1

1.48e-0391222SM00089
DomainDNA/RNA_helicase_DEAH_CS

DHX36 DHX9 DHX34

1.53e-03351223IPR002464
DomainEGF-like_CS

SELP NID2 RELN ADAM18 CUBN MALRD1 MUC4

1.64e-032611227IPR013032
DomainEGF_2

SELP NID2 RELN ADAM18 CUBN MALRD1 MUC4

1.79e-032651227PS01186
DomainC_TYPE_LECTIN_1

SELP PKD1 LY75 CLEC2B

1.87e-03801224PS00615
DomainDEAH_ATP_HELICASE

DHX36 DHX9 DHX34

1.94e-03381223PS00690
DomainLectin_C

SELP PKD1 LY75 CLEC2B

2.24e-03841224PF00059
DomainCLECT

SELP PKD1 LY75 CLEC2B

2.24e-03841224SM00034
DomainPKD

KIAA0319 PKD1

2.24e-03111222PS50093
DomainPKD_dom

KIAA0319 PKD1

2.24e-03111222IPR000601
Domain-

KIAA0319 PKD1

2.24e-031112222.60.40.670
DomainC_TYPE_LECTIN_2

SELP PKD1 LY75 CLEC2B

2.33e-03851224PS50041
DomainC-type_lectin-like

SELP PKD1 LY75 CLEC2B

2.44e-03861224IPR001304
DomainEGF_dom

NID2 CUBN

2.68e-03121222IPR024731
DomainEGF_3

NID2 CUBN

2.68e-03121222PF12947
DomainC-type_lectin-like/link

SELP PKD1 LY75 CLEC2B

4.05e-03991224IPR016186
DomainEGF

SELP NID2 RELN CUBN MALRD1 MUC4

4.48e-032351226SM00181
DomainVWF_type-D

MUC4 MUC5AC

4.78e-03161222IPR001846
DomainVWFD

MUC4 MUC5AC

4.78e-03161222PS51233
DomainVWD

MUC4 MUC5AC

4.78e-03161222SM00216
DomainVWD

MUC4 MUC5AC

4.78e-03161222PF00094
DomainCTDL_fold

SELP PKD1 LY75 CLEC2B

5.33e-031071224IPR016187
DomainHATPase_c

HSP90AA1 HSP90AB1

6.05e-03181222SM00387
DomainKelch

KLHL6 KLHL2 KLHL42

6.46e-03581223SM00612
Pubmed

Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy.

SYNE1 SPTAN1 ZZEF1 ALMS1 SYNE2 PKD1 MUC5AC HSP90AA1 IGSF3 HSP90AB1

2.42e-091871301026460568
Pubmed

The HSP90 family of genes in the human genome: insights into their divergence and evolution.

HSP90AB4P HSP90AA1 HSP90AA4P HSP90AA2P HSP90AB1

2.85e-0916130516269234
Pubmed

CHK2-BRCA1 tumor-suppressor axis restrains oncogenic Aurora-A kinase to ensure proper mitotic microtubule assembly.

TPP2 SPTAN1 PSMA5 SPTBN1 NKRF DHX9 ALMS1 AGL PYGL CTNNB1 PALLD HSP90AA1 HSP90AB1

4.74e-084941301326831064
Pubmed

IL-6 induces MUC4 expression through gp130/STAT3 pathway in gastric cancer cell lines.

STAT3 MUC4 IL6ST

5.10e-083130318573283
Pubmed

Involvement of heat-shock protein 90 in the interleukin-6-mediated signaling pathway through STAT3.

STAT3 HSP90AA1 HSP90AB1

2.04e-074130312559950
Pubmed

Mapping of the gene family for human heat-shock protein 90 alpha to chromosomes 1, 4, 11, and 14.

HSP90AA1 HSP90AA4P HSP90AA2P

2.04e-07413031740332
Pubmed

Quantitation of HERV-K env gene expression and splicing in human breast cancer.

ERVK-7 ERVK-21 ERVK-18

5.08e-075130312629516
Pubmed

A gp130-Src-YAP module links inflammation to epithelial regeneration.

STAT3 YAP1 IL6ST

5.08e-075130325731159
Pubmed

Mechanisms and Consequences of Dopamine Depletion-Induced Attenuation of the Spinophilin/Neurofilament Medium Interaction.

NID2 SPTAN1 SPTBN1 DHX9 ATAD3B ATAD3C IQSEC1

6.58e-07131130728634551
Pubmed

Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.

DHX36 MYO5B WWP1 SPTAN1 PSMA5 SPTBN1 SIM2 NKRF DHX9 TULP4 YAP1 CTNNB1 MED17 MED27 HECTD1 MED12 HSP90AA1 HSP90AB1

9.77e-0712471301827684187
Pubmed

A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways.

KLHL6 DYNLT1 SIM2 ACAD11 SYNE2 PYGL CTSB HECTD1 HSP90AA1 HSP90AB1

1.19e-063631301025036637
Pubmed

KCTD9 inhibits the Wnt/β-catenin pathway by decreasing the level of β-catenin in colorectal cancer.

SPTBN1 DHX9 PYGL CTNNB1 HSP90AA1 HSP90AB1

2.73e-06104130636055981
Pubmed

A role for AGL ubiquitination in the glycogen storage disorders of Lafora and Cori's disease.

AGL HSP90AA1 HSP90AB1

2.82e-068130317908927
Pubmed

A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.

SYNE1 WWP1 SPTBN1 GIT2 ALMS1 AGL SYNE2 PALLD IL6ST HSP90AA1 HSP90AB1

2.87e-064971301123414517
Pubmed

USP45 and Spindly are part of the same complex implicated in cell migration.

TPP2 SPTAN1 SPTBN1 DHX9 ATAD3B HSP90AA1 HSP90AA2P HSP90AB1

3.09e-06235130830258100
Pubmed

Mediator and cohesin connect gene expression and chromatin architecture.

STAT3 MED17 MED27 MED12

3.56e-0628130420720539
Pubmed

Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumorigenesis.

STAT3 CTNNB1 TAP1

4.22e-069130329909986
Pubmed

USP9X-mediated NRP1 deubiquitination promotes liver fibrosis by activating hepatic stellate cells.

SPTAN1 SPTBN1 PYGL

6.01e-0610130336653359
Pubmed

Optimized fragmentation schemes and data analysis strategies for proteome-wide cross-link identification.

RALGAPA1 DHX36 SPTAN1 PSMA5 SPTBN1 STAT3 DHX9 PALLD HSP90AA1 HSP90AA2P HSP90AB1

6.08e-065381301128524877
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

TPP2 DHX36 KIF1A SPTAN1 SPTBN1 NKRF RRP9 SYNE2 GEMIN4 PYGL HECTD1 MED12

6.67e-066531301222586326
Pubmed

Systematic proteomics of endogenous human cohesin reveals an interaction with diverse splicing factors and RNA-binding proteins required for mitotic progression.

MYO5B SPTAN1 SPTBN1 POF1B PALLD MED12 HSP90AA1 HSP90AB1

9.00e-06272130831010829
Pubmed

Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways.

NID2 SPTAN1 PSMA5 SPTBN1 PKD1 GEMIN4 PYGL MUC5AC IQGAP3 HSP90AA1 HSP90AB1

9.46e-065641301121565611
Pubmed

PTPN14 regulates Roquin2 stability by tyrosine dephosphorylation.

KLHL6 ZCCHC24 TPP2 DHX36 SPTAN1 SPTBN1 NKRF DHX9 RRP9 IQSEC1 HSP90AA1 HSP90AB1

9.72e-066781301230209976
Pubmed

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.

PAPPA2 SEMG2 NID2 WWP1 CUBN SERPINA6 TGM4 PYGL CTSB MUC4 IL6ST CA1 HSP90AA1 HSP90AA2P HSP90AB1

1.19e-0510701301523533145
Pubmed

CCT3 acts upstream of YAP and TFCP2 as a potential target and tumour biomarker in liver cancer.

SPTAN1 SPTBN1 DHX9 ATAD3B YAP1 HSP90AA1 HSP90AA4P HSP90AB1

1.36e-05288130831501420
Pubmed

Exome sequencing in four families with neurodevelopmental disorders: genotype-phenotype correlation and identification of novel disease-causing variants in VPS13B and RELN.

RELN VPS13B

1.39e-052130238771357
Pubmed

Regulation of the Hippo/YAP axis by CXCR7 in the tumorigenesis of gastric cancer.

YAP1 ACKR3

1.39e-052130237950281
Pubmed

Nesprins: a novel family of spectrin-repeat-containing proteins that localize to the nuclear membrane in multiple tissues.

SYNE1 SYNE2

1.39e-052130211792814
Pubmed

Cancer cell-derived microparticles bearing P-selectin glycoprotein ligand 1 accelerate thrombus formation in vivo.

SELP F3

1.39e-052130219667060
Pubmed

MUC4-induced nuclear translocation of β-catenin: a novel mechanism for growth, metastasis and angiogenesis in pancreatic cancer.

CTNNB1 MUC4

1.39e-052130224374017
Pubmed

A mouse tumor-specific transplantation antigen is a heat shock-related protein.

HSP90AA1 HSP90AB1

1.39e-05213023458168
Pubmed

Expression and prognosis analyses of the fibronectin type-III domain-containing (FNDC) protein family in human cancers: A Review.

FNDC7 FNDC8

1.39e-052130236626432
Pubmed

Lack of glycoprotein 130/signal transducer and activator of transcription 3-mediated signaling in hepatocytes enhances chronic liver injury and fibrosis progression in a model of sclerosing cholangitis.

STAT3 IL6ST

1.39e-052130220382701
Pubmed

Upregulated YAP promotes oncogenic CTNNB1 expression contributing to molecular pathology of hepatoblastoma.

YAP1 CTNNB1

1.39e-052130235404538
Pubmed

Co-activation of STAT3 and YES-Associated Protein 1 (YAP1) Pathway in EGFR-Mutant NSCLC.

STAT3 YAP1

1.39e-052130228376152
Pubmed

YAP and β-catenin cooperate to drive H. pylori-induced gastric tumorigenesis.

YAP1 CTNNB1

1.39e-052130236959122
Pubmed

Mechanisms of cellular crosstalk in the gastric tumor microenvironment are mediated by YAP1 and STAT3.

YAP1 IL6ST

1.39e-052130237957015
Pubmed

Low incidence of IL6ST (gp130) mutations in exon 6 in lung cancer of a Chinese cohort.

STAT3 IL6ST

1.39e-052130225242236
Pubmed

β-Catenin Sustains and Is Required for YES-associated Protein Oncogenic Activity in Cholangiocarcinoma.

YAP1 CTNNB1

1.39e-052130235489428
Pubmed

Cell surface heparan sulfate proteoglycans are involved in the binding of Hsp90α and Hsp90β to the cell plasma membrane.

HSP90AA2P HSP90AB1

1.39e-052130226651243
Pubmed

Proliferation, migration, and resistance to oxidative and thermal stresses of HT1080 cells with knocked out genes encoding Hsp90α and Hsp90β.

HSP90AA1 HSP90AB1

1.39e-052130237406487
Pubmed

Spectrin-actin interaction is required for neurite extension in NB 2a/dl neuroblastoma cells.

SPTAN1 SPTBN1

1.39e-05213028776664
Pubmed

Heat shock protein 90 overexpression independently predicts inferior disease-free survival with differential expression of the alpha and beta isoforms in gastrointestinal stromal tumors.

HSP90AA1 HSP90AB1

1.39e-052130219047110
Pubmed

Heat shock protein HSP86 expression during mouse embryo development, especially in the germ-line.

HSP90AA1 HSP90AB1

1.39e-052130212136260
Pubmed

A critical role for interleukin-6 family-mediated Stat3 activation in osteoblast differentiation and bone formation.

STAT3 IL6ST

1.39e-052130216679075
Pubmed

Expression of hsp90 and cyclin D1 in human breast cancer.

HSP90AA1 HSP90AB1

1.39e-052130210376793
Pubmed

Human coronavirus dependency on host heat shock protein 90 reveals an antiviral target.

HSP90AA1 HSP90AB1

1.39e-052130233179566
Pubmed

Regulation of embryonic stem cell pluripotency by heat shock protein 90.

HSP90AA1 HSP90AB1

1.39e-052130222696450
Pubmed

N-terminal nesprin-2 variants regulate β-catenin signalling.

SYNE2 CTNNB1

1.39e-052130227321956
Pubmed

Heat shock protein 90 (HSP90) contributes to cytosolic translocation of extracellular antigen for cross-presentation by dendritic cells.

TAP1 HSP90AA1

1.39e-052130221930907
Pubmed

Reducing YAP expression in Pkd1 mutant mice does not improve the cystic phenotype.

YAP1 PKD1

1.39e-052130232592332
Pubmed

Nesprins: tissue-specific expression of epsilon and other short isoforms.

SYNE1 SYNE2

1.39e-052130224718612
Pubmed

Helicobacter pylori CagA phosphorylation status determines the gp130-activated SHP2/ERK and JAK/STAT signal transduction pathways in gastric epithelial cells.

STAT3 IL6ST

1.39e-052130220348091
Pubmed

Targeted ablation of nesprin 1 and nesprin 2 from murine myocardium results in cardiomyopathy, altered nuclear morphology and inhibition of the biomechanical gene response.

SYNE1 SYNE2

1.39e-052130224586179
Pubmed

Cloning and analysis of a human 86-kDa heat-shock-protein-encoding gene.

HSP90AA1 HSP90AA2P

1.39e-05213022591742
Pubmed

The Wnt/β-catenin pathway cross-talks with STAT3 signaling to regulate survival of retinal pigment epithelium cells.

STAT3 CTNNB1

1.39e-052130223056515
Pubmed

IQGAP3, a YAP Target, Is Required for Proper Cell-Cycle Progression and Genome Stability.

YAP1 IQGAP3

1.39e-052130234183451
Pubmed

Nesprin-1 and -2 are involved in the pathogenesis of Emery Dreifuss muscular dystrophy and are critical for nuclear envelope integrity.

SYNE1 SYNE2

1.39e-052130217761684
Pubmed

Translational reprogramming in response to accumulating stressors ensures critical threshold levels of Hsp90 for mammalian life.

HSP90AA1 HSP90AB1

1.39e-052130236270993
Pubmed

Hsp90 regulation of fibroblast activation in pulmonary fibrosis.

HSP90AA1 HSP90AB1

1.39e-052130228239659
Pubmed

Nesprin-1-alpha2 associates with kinesin at myotube outer nuclear membranes, but is restricted to neuromuscular junction nuclei in adult muscle.

SYNE1 SYNE2

1.39e-052130231578382
Pubmed

Circ-HSP90A expedites cell growth, stemness, and immune evasion in non-small cell lung cancer by regulating STAT3 signaling and PD-1/PD-L1 checkpoint.

STAT3 HSP90AA1

1.39e-052130235750765
Pubmed

Despite their structural similarities, the cytosolic isoforms of human Hsp90 show different behaviour in thermal unfolding due to their conformation: An FTIR study.

HSP90AA1 HSP90AB1

1.39e-052130237028636
Pubmed

Leukemia inhibitory factor coordinates the down-regulation of the visual cycle in the retina and retinal-pigmented epithelium.

STAT3 IL6ST

1.39e-052130222645143
Pubmed

n-3 PUFAs reduce T-helper 17 cell differentiation by decreasing responsiveness to interleukin-6 in isolated mouse splenic CD4⁺ T cells.

STAT3 IL6ST

1.39e-052130224944284
Pubmed

Cloning of a portion of the chromosomal gene and cDNA for human beta-fodrin, the nonerythroid form of beta-spectrin.

SPTAN1 SPTBN1

1.39e-05213028406479
Pubmed

Conserved conformational changes in the ATPase cycle of human Hsp90.

HSP90AA1 HSP90AB1

1.39e-052130218400751
Pubmed

Uniaxial cyclic stretch enhances osteogenic differentiation of OPLL-derived primary cells via YAP-Wnt/β-catenin axis.

YAP1 CTNNB1

1.39e-052130236749152
Pubmed

Differential involvement of gp130 signalling pathways in modulating tobacco carcinogen-induced lung tumourigenesis.

STAT3 IL6ST

1.39e-052130224727895
Pubmed

Requirement of gp130 signaling for the AGM hematopoiesis.

STAT3 IL6ST

1.39e-052130212691915
Pubmed

Polycystin-1 C-terminal tail associates with beta-catenin and inhibits canonical Wnt signaling.

PKD1 CTNNB1

1.39e-052130218632682
Pubmed

Columbamine suppresses proliferation and invasion of melanoma cell A375 via HSP90-mediated STAT3 activation.

STAT3 HSP90AA1

1.39e-052130232669028
Pubmed

Increased gp130 signaling in combination with inhibition of the MEK/ERK pathway facilitates embryonic stem cell isolation from normally refractory murine CBA blastocysts.

STAT3 IL6ST

1.39e-052130215996112
Pubmed

STAT3 paradoxically stimulates β-catenin expression but inhibits β-catenin function.

STAT3 CTNNB1

1.39e-052130225348333
Pubmed

Inactivation of one copy of the mouse neurotrophin-3 gene induces cardiac sympathetic deficits.

NCOA3 NTF3

1.39e-052130211015591
Pubmed

MUC4 and MUC5AC are highly specific tumour-associated mucins in biliary tract cancer.

MUC4 MUC5AC

1.39e-052130218475301
Pubmed

Nesprin-1 and nesprin-2 regulate endothelial cell shape and migration.

SYNE1 SYNE2

1.39e-052130224931616
Pubmed

Hsp90 is cleaved by reactive oxygen species at a highly conserved N-terminal amino acid motif.

HSP90AA1 HSP90AB1

1.39e-052130222848402
Pubmed

Mechanism of dimer formation of the 90-kDa heat-shock protein.

HSP90AA1 HSP90AB1

1.39e-05213027588731
Pubmed

STAT3 activation regulates growth, inflammation, and vascularization in a mouse model of gastric tumorigenesis.

STAT3 IL6ST

1.39e-052130217030178
Pubmed

Epidermal YAP2-5SA-ΔC Drives β-Catenin Activation to Promote Keratinocyte Proliferation in Mouse Skin In Vivo.

YAP1 CTNNB1

1.39e-052130227816394
Pubmed

STAT3 activation in infection and infection-associated cancer.

STAT3 CTNNB1

1.39e-052130228223148
Pubmed

Diffuse large B-cell lymphoma-derived exosomes push macrophage polarization toward M2 phenotype via GP130/STAT3 signaling pathway.

STAT3 IL6ST

1.39e-052130234922904
Pubmed

Identification of a mouse brain beta-spectrin cDNA and distribution of its mRNA in adult tissues.

SPTAN1 SPTBN1

1.39e-05213021742606
Pubmed

HSP90 expression and early recurrence in gastroenteropancreatic neuroendocrine tumors: Potential for a novel therapeutic target.

HSP90AA1 HSP90AB1

1.39e-052130233080545
Pubmed

Circulating Hsp90 Isoform Levels in Overweight and Obese Children and the Relation to Nonalcoholic Fatty Liver Disease: Results from a Cross-Sectional Study.

HSP90AA2P HSP90AB1

1.39e-052130231885746
Pubmed

Heat shock protein 90 facilitates SARS-CoV-2 structural protein-mediated virion assembly and promotes virus-induced pyroptosis.

HSP90AA1 HSP90AB1

1.39e-052130237011862
Pubmed

GP130-STAT3 regulates epithelial cell migration and is required for repair of the bronchiolar epithelium.

STAT3 IL6ST

1.39e-052130218467707
Pubmed

Activation of the GP130-STAT3 axis and its potential implications in nonalcoholic fatty liver disease.

STAT3 IL6ST

1.39e-052130225747354
Pubmed

Expression and therapeutic relevance of heat-shock protein 90 in pancreatic endocrine tumors.

HSP90AA1 HSP90AB1

1.39e-052130222194440
Pubmed

Circadian expression of 86- and 84-kDa heat shock proteins in the mouse suprachiasmatic nucleus.

HSP90AA1 HSP90AB1

1.39e-052130218480550
Pubmed

Mitochondrial heat shock protein-90 modulates vascular smooth muscle cell survival and the vascular injury response in vivo.

HSP90AA1 HSP90AB1

1.39e-052130222841823
Pubmed

YAP via interacting with STAT3 regulates VEGF-induced angiogenesis in human retinal microvascular endothelial cells.

STAT3 YAP1

1.39e-052130230342005
Pubmed

Substitution of only two residues of human Hsp90alpha causes impeded dimerization of Hsp90beta.

HSP90AA1 HSP90AB1

1.39e-052130218347946
Pubmed

STAT3 integrates cytokine and neurotrophin signals to promote sympathetic axon regeneration.

STAT3 IL6ST

1.39e-052130223831387
Pubmed

Nesprins are mechanotransducers that discriminate epithelial-mesenchymal transition programs.

SYNE2 CTNNB1

1.39e-052130232790861
Pubmed

Alteration of ocular surface mucins in MUC5AC-DTA transgenic mice.

MUC4 MUC5AC

1.39e-052130219158956
Pubmed

Multiple novel nesprin-1 and nesprin-2 variants act as versatile tissue-specific intracellular scaffolds.

SYNE1 SYNE2

1.39e-052130222768332
Pubmed

CXCR7 silencing inhibits the migration and invasion of human tumor endothelial cells derived from hepatocellular carcinoma by suppressing STAT3.

STAT3 ACKR3

1.39e-052130229901083
Pubmed

Interdependence of SS18-SSX-driven YAP1 and β-Catenin Activation in Synovial Sarcoma.

YAP1 CTNNB1

1.39e-052130236920288
InteractionPSKH2 interactions

HSP90AB4P DYNLT1 IQGAP3 HSP90AA1 HSP90AA4P HSP90AB1

3.70e-06671256int:PSKH2
InteractionGAN interactions

SYNE1 SPTAN1 ZZEF1 ALMS1 SYNE2 PKD1 MUC5AC HSP90AA1 IGSF3 HSP90AB1

4.08e-0625312510int:GAN
InteractionCDK15 interactions

HSP90AB4P POF1B STAT3 ATAD3B HSP90AA1 HSP90AA4P HSP90AB1

8.41e-061171257int:CDK15
InteractionUNC45B interactions

HSP90AB4P HSP90AA1 HSP90AA4P HSP90AB1

9.46e-06221254int:UNC45B
InteractionMED14 interactions

ACAD11 YAP1 GEMIN4 INTS9 MED17 MED27 HECTD1 MED12

1.15e-051711258int:MED14
InteractionNR1I3 interactions

NCOA3 MED17 MED12 HSP90AA1 HSP90AB1

1.17e-05481255int:NR1I3
InteractionSTK32C interactions

ATAD3B IQSEC1 IQGAP3 HSP90AA1 HSP90AA4P HSP90AB1

1.69e-05871256int:STK32C
InteractionAGO1 interactions

DHX36 HSP90AB4P DHX9 DCAF10 GEMIN4 HSP90AA1 HSP90AA4P HSP90AB1

1.89e-051831258int:AGO1
InteractionCCDC117 interactions

HSP90AB4P HSP90AA1 HSP90AA4P HSP90AB1

1.90e-05261254int:CCDC117
InteractionRABL2A interactions

TBC1D9B SPTAN1 SPTBN1 ALMS1

2.57e-05281254int:RABL2A
InteractionBRCA1 interactions

TPP2 NCOA3 MCPH1 SPTAN1 PSMA5 SPTBN1 CUBN SIM2 NKRF STAT3 DHX9 ALMS1 AGL EXO1 PYGL CTNNB1 MED17 PALLD MED12 HSP90AA1 HSP90AB1

2.68e-05124912521int:BRCA1
InteractionTMOD4 interactions

GIT2 ACAD11 HSP90AA4P HSP90AB1

2.97e-05291254int:TMOD4
InteractionSTK35 interactions

HSP90AB4P HSP90AA1 HSP90AA4P HSP90AB1

3.41e-05301254int:STK35
InteractionRUNX1 interactions

DHX36 FBXW12 WWP1 DHX9 YAP1 PKD1 INTS9 CTNNB1 MED17 MED12

3.48e-0532412510int:RUNX1
InteractionANKK1 interactions

HSP90AB4P HSP90AA1 HSP90AA4P HSP90AB1

3.90e-05311254int:ANKK1
InteractionACTN1 interactions

SPTAN1 DYNLT1 GIT2 YAP1 PKD1 CTNNB1 CTSB PALLD HSP90AA1 HSP90AB1

5.35e-0534112510int:ACTN1
InteractionNR4A1 interactions

NCOA3 STAT3 ACAD11 RRP9 ROBO2 SMARCD3 CTNNB1 HSP90AB1

5.39e-052121258int:NR4A1
InteractionCDKL4 interactions

HSP90AB4P HSP90AA1 HSP90AB1

6.37e-05131253int:CDKL4
InteractionMED13L interactions

ATAD3B ACAD11 MED17 MED27 MED12

7.95e-05711255int:MED13L
InteractionPRRG1 interactions

WWP1 DCAF10 YAP1

1.00e-04151253int:PRRG1
InteractionMED16 interactions

ATAD3B ACAD11 MED17 MED27 HECTD1 MED12

1.04e-041201256int:MED16
InteractionMED8 interactions

ACAD11 YAP1 INTS9 MED17 MED27 MED12

1.08e-041211256int:MED8
InteractionSRMS interactions

HSP90AB4P HSP90AA1 HSP90AA4P HSP90AB1

1.08e-04401254int:SRMS
InteractionNPHP4 interactions

NID2 SPTAN1 SPTBN1 PKD1 PYGL MUC5AC HSP90AA1 HSP90AB1

1.14e-042361258int:NPHP4
InteractionRUNX2 interactions

FBXW12 WWP1 TAF1A STAT3 YAP1 CTNNB1

1.35e-041261256int:RUNX2
InteractionSGK2 interactions

HSP90AB4P HSP90AA1 HSP90AA4P HSP90AB1

1.44e-04431254int:SGK2
InteractionREN interactions

HSP90AB4P TRMT44 CTSB

1.49e-04171253int:REN
InteractionMED18 interactions

ATAD3B ACAD11 MED17 MED27 MED12

1.49e-04811255int:MED18
InteractionRND1 interactions

RALGAPA1 KIF26B SPTAN1 SPTBN1 NEDD1 FAM171A1 ARHGAP5 CTNNB1

1.52e-042461258int:RND1
InteractionCOPS5 interactions

DHX36 BCL2L14 RELN SPTAN1 SPTBN1 POF1B NKRF STAT3 DHX9 AGL GEMIN4 KLHL42 PYGL CTNNB1 HECTD1 HSP90AA1 HSP90AA2P HSP90AB1

1.54e-04110212518int:COPS5
InteractionTSSK1B interactions

TPP2 CTNNB1 HSP90AA1 HSP90AB1

1.58e-04441254int:TSSK1B
InteractionMED15 interactions

ACAD11 YAP1 INTS9 MED17 MED27 MED12

1.68e-041311256int:MED15
InteractionLIMK2 interactions

HSP90AB4P IQSEC1 HSP90AA1 HSP90AA4P HSP90AB1

1.77e-04841255int:LIMK2
InteractionMAGEA3 interactions

DHX9 ATAD3B ATAD3C ACAD11 IQSEC1 HSP90AB1

1.90e-041341256int:MAGEA3
InteractionMED12L interactions

ACAD11 MED17 MED27 MED12

2.05e-04471254int:MED12L
InteractionTSSK6 interactions

HSP90AB4P HSP90AA1 HSP90AA4P HSP90AB1

2.05e-04471254int:TSSK6
InteractionTNNI3K interactions

KLHL42 HSP90AA1 HSP90AB1

2.10e-04191253int:TNNI3K
InteractionKIF23 interactions

DHX36 HSP90AB4P MYO5B SPTAN1 SPTBN1 NKRF DHX9 ATAD3B ATAD3C ALMS1 GEMIN4 CTNNB1 HECTD1 IQGAP3 HSP90AA4P HSP90AA2P HSP90AB1

2.14e-04103112517int:KIF23
InteractionFER interactions

STAT3 CTNNB1 HSP90AA1 HSP90AB1

2.61e-04501254int:FER
InteractionMED17 interactions

ACAD11 YAP1 INTS9 MED17 MED27 HECTD1 MED12

2.69e-042021257int:MED17
InteractionAURKB interactions

HSP90AB4P PSMA5 ZZEF1 DHX9 ATAD3B ATAD3C AGL GEMIN4 CTNNB1 HECTD1 HSP90AA1 HSP90AA4P HSP90AA2P HSP90AB1

2.70e-0476112514int:AURKB
InteractionMED7 interactions

ATAD3B ACAD11 MED17 MED27 MED12

2.71e-04921255int:MED7
InteractionKIF20A interactions

RALGAPA1 KIF1A SYNE1 SPTAN1 PSMA5 SPTBN1 DHX9 ATAD3B SAMD9L ATAD3C ALMS1 RRP9 SYNE2 TXNRD3 CTNNB1 HSP90AA2P HSP90AB1

2.71e-04105212517int:KIF20A
InteractionMAP3K6 interactions

HSP90AB4P AGL HSP90AA1 HSP90AA4P

2.81e-04511254int:MAP3K6
InteractionBRWD1 interactions

DYNLT1 STAT3 HSP90AA1 HSP90AB1

2.81e-04511254int:BRWD1
InteractionPDIK1L interactions

HSP90AB4P HSP90AA1 HSP90AB1

2.86e-04211253int:PDIK1L
InteractionMED1 interactions

KIF1A ACAD11 YAP1 MED17 MED27 HECTD1 MED12

3.03e-042061257int:MED1
InteractionNUDCD2 interactions

RALGAPA1 TPP2 SYNE1 SPTAN1 SPTBN1 DHX9 DCAF10 PKD1 HSP90AA1 HSP90AB1

3.15e-0442412510int:NUDCD2
InteractionZNF215 interactions

HECTD1 HSP90AA1 HSP90AB1

3.29e-04221253int:ZNF215
InteractionSREBF1 interactions

NEDD1 SMARCD3 MED17 HECTD1 MED12 HSP90AA1

3.49e-041501256int:SREBF1
InteractionSFN interactions

RALGAPA1 KIF26B SPTAN1 SPTBN1 POF1B STAT3 FAM171A1 ALMS1 YAP1 EXO1 CTNNB1 HECTD1 PALLD

3.70e-0469212513int:SFN
InteractionAGO3 interactions

HSP90AB4P SPTAN1 SPTBN1 ATAD3B HSP90AA1 HSP90AB1

3.87e-041531256int:AGO3
InteractionCDK13 interactions

HSP90AB4P TRMT44 HECTD1 HSP90AA1 HSP90AA4P HSP90AB1

3.87e-041531256int:CDK13
InteractionPTGES3 interactions

DHX36 HSP90AB4P KIF1A SIM2 ACAD11 PYGL DHX34 HSP90AA1 HSP90AA4P HSP90AB1

4.00e-0443712510int:PTGES3
InteractionAMHR2 interactions

HSP90AB4P HSP90AA1 HSP90AA4P HSP90AB1

4.04e-04561254int:AMHR2
InteractionMED6 interactions

ACAD11 MED17 MED27 HECTD1 MED12

4.17e-041011255int:MED6
InteractionYAP1 interactions

WWP1 SPTAN1 PSMA5 SPTBN1 NKRF DHX9 ATAD3B TULP4 YAP1 CTNNB1 MED17 MED27 PALLD MED12 HSP90AA1 HSP90AA4P HSP90AB1

4.30e-04109512517int:YAP1
InteractionMED29 interactions

NRDE2 ACAD11 MED17 MED27 MED12

4.36e-041021255int:MED29
InteractionMED27 interactions

ACAD11 YAP1 MED17 MED27 MED12

4.36e-041021255int:MED27
InteractionRHOQ interactions

RALGAPA1 SPTAN1 SPTBN1 GIT2 FAM171A1 ARHGAP5 CTNNB1 IQGAP3 IL6ST IGSF3

4.37e-0444212510int:RHOQ
InteractionEEF1AKMT3 interactions

TBC1D9B HSP90AB4P STAT3 IQSEC1 GEMIN4 CTSB VPS13B HSP90AA1 HSP90AB1

4.50e-043641259int:EEF1AKMT3
Cytoband12p13-p12

BCL2L14 CLEC2B

4.76e-054130212p13-p12
GeneFamilyDEAH-box helicases

DHX36 DHX9 DHX34

6.16e-0516893500
GeneFamilySpectrin repeat containing nuclear envelope family

SYNE1 SYNE2

1.43e-0448921252
GeneFamilyHeat shock 90kDa proteins

HSP90AA1 HSP90AB1

2.37e-045892586
GeneFamilyEF-hand domain containing|Spectrins

SPTAN1 SPTBN1

4.95e-0478921113
GeneFamilyCyclins|Mediator complex

MED17 MED27 MED12

5.65e-04338931061
GeneFamilyKelch like|BTB domain containing

KLHL6 KLHL2 KLHL42

1.15e-0342893617
GeneFamilyWD repeat domain containing

TBL1Y FBXW12 NEDD1 TULP4 DCAF10 RRP9

1.86e-03262896362
GeneFamilyCD molecules|Mucins

MUC4 MUC5AC

4.73e-0321892648
CoexpressionQUEREC_MODEL_PBMC_YF_17D_VACCINE_AGE_18_45YO_3DY_PREDICTIVE

CRAT CXCR6 ACKR3 SMARCD3 CTSB

3.44e-06481265M41133
CoexpressionROETH_TERT_TARGETS_DN

SPTBN1 CXCR6 CLEC2B

8.92e-0691263M2891
CoexpressionAtlasDevelopingGonad_e16.5_epididymis_emap-29702_top-relative-expression-ranked_1000

ZCCHC24 DHX36 NCOA3 KLHL2 SPTBN1 GIT2 SLC16A12 STAT3 ARHGAP5 TULP4 SYNE2 ROBO2 CTNNB1 CALCRL HSP90AB1

4.38e-0579012115gudmap_developingGonad_e16.5_epididymis_1000
CoexpressionAtlaskidney_P0_JuxtaGlom_Ren1_k-means-cluster#3_top-relative-expression-ranked_1000

PAPPA2 RELN NTF3 SIM2 SERPINA6 AGL GLP1R PYGL CTSB

4.70e-052931219gudmap_kidney_P0_JuxtaGlom_Ren1_k3_1000
CoexpressionAtlaskidney_P0_JuxtaGlom_Ren1_top-relative-expression-ranked_1000

PAPPA2 RELN NTF3 SYNE1 CUBN SIM2 SERPINA6 F3 SLC16A12 SAMD9L AGL GLP1R PYGL CALCRL CTSB IL6ST

5.61e-0590512116gudmap_kidney_P0_JuxtaGlom_Ren1_1000
ToppCelldroplet-Limb_Muscle-MUSCLE-30m|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYNE1 ARHGAP5 SAMD9L SYNE2 TAP1 HSP90AA1 HSP90AB1

7.26e-07178125701dafd19de04eff459253eaa9a35debf8f3deedf
ToppCellwk_20-22-Epithelial-Proximal_epithelial-basal_proximal|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

BCL2L14 NTF3 F3 POF1B ACKR3 MUC4 IGSF3

7.26e-0717812579534c4f4e950bb1498c1737ca1713e7f37d0aff2
ToppCellCOVID-19-kidney-Stressed_EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

SELP SPTBN1 CTNNB1 CALCRL HSP90AA1 CLEC2B HSP90AB1

7.53e-071791257754f69bac7a1d5137f5141f6193285ccbfe361cb
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DHX36 WWP1 SPTBN1 POF1B ARHGAP5 SAMD9L SYNE2

1.16e-06191125760c986d2dcbc19d9338c03da6cb5e1d92fd48f8e
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

WWP1 SPTBN1 POF1B ARHGAP5 SAMD9L SYNE2 CTNNB1

1.16e-06191125709db184cb90fe282a14474d7217068c58092c6f8
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL-30m|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DHX36 WWP1 SPTBN1 POF1B ARHGAP5 SAMD9L SYNE2

1.16e-061911257973117730d6ba5f127e7a0bfabfd0ff2ca7ac131
ToppCell10x_5'_v1-Non-neoplastic-Lymphoid-CD4/CD8-Stress_sig-F_2|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SYNE1 NKRF CXCR6 SYNE2 TAP1 HSP90AA1 HSP90AB1

1.38e-061961257ea8eceacc5d5e1a22b77c31e7c45985dc7bb15de
ToppCell5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MYO5B SPTAN1 F3 MUC4 MUC5AC PALLD MAP3K19

1.43e-0619712575c4cee914baf7cb43e9cb99cc9e3ae823856dc15
ToppCellmild-CD4+_T_naive|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

WWP1 SPTBN1 STAT3 ARHGAP5 SYNE2 IL6ST HSP90AB1

1.53e-0619912573e4baaf4ee23f257d821194468102c00a8ad2f21
ToppCellcontrol|World / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

SPTBN1 F3 ARHGAP5 SYNE2 HECTD1 MUC4 PALLD

1.58e-06200125797f36d2c197e03d93a1fc59949d77ae90f6e6a9a
ToppCellNS-control|NS / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

F3 ARHGAP5 YAP1 SYNE2 HECTD1 MUC4 PALLD

1.58e-062001257ecbe89ff95d046155b984c8c150e0b9e7278f839
ToppCellEndothelial-B-IPF_04|World / lung cells shred on cell class, cell subclass, sample id

RELN KIF26B HEPH FAM171A1 ACKR3 CALCRL

9.21e-061721256d4e98ff9c7cbc95457e1d71fa60f151a2f178dae
ToppCellfacs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RAD51AP2 NECAB1 GLP1R ULK4 FNDC8 MUC4

9.84e-061741256f1fe1f4216748a9562dd03bd48c70b23c7ff4d1d
ToppCellLPS_only-Epithelial_alveolar-AT_2-Differentiating_AT2|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

BCL2L14 MYO5B F3 RAD51AP2 RRP9 SYNE2

1.16e-051791256fd2cbee532e7b44113410dca82aec7db1a7fb69f
ToppCelldroplet-Heart-HEART_(LV+RV_ONLY)-30m-Endothelial-endocardial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SELP RELN ACKR3 CALCRL FNDC8 IL6ST

1.23e-051811256cef034030e6b029a49ae56be37ea1fac1a5c350e
ToppCellControl-Epithelial_cells-Airway_mucous|Control / group, cell type (main and fine annotations)

BTNL8 NXPH1 SIM2 POF1B MUC4 MUC5AC

1.31e-05183125615d24a4fb1ffe6cbafbd54fcd7dde9ddcfbe03b2
ToppCellFetal_29-31_weeks-Endothelial-endothelial_cell_of_vein-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

SELP NTF3 POF1B FAM171A1 ACKR3 CALCRL

1.31e-051831256c1297d8eddfc7132e84ceef14f01b6281f9d0f6a
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

NID2 RELN KIF26B SYNE1 NECAB1 PALLD

1.39e-05185125634fcfd635c828dad9643bbf1c908d79282d6f5d9
ToppCellfacs-Limb_Muscle-ForelimbandHindlimb|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZCCHC24 TPP2 STAT3 ARHGAP5 ACKR3 HSP90AA1

1.39e-051851256eb7d3c1363d5fedc611f9c1a91ea823de251355e
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

NID2 RELN KIF26B SYNE1 NECAB1 PALLD

1.39e-0518512568816f2909ed11833ff3d0ed96b9cb6d6fe9e1578
ToppCelldroplet-Liver-Hepatocytes-24m-Endothelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SELP NTF3 FAM171A1 SYCP2 CALCRL IL6ST

1.44e-0518612562cae34336f184f971f7c8684cc27c23a4e7369ed
ToppCelldroplet-Tongue-nan-24m-Epithelial-suprabasal|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYO5B NTF3 F3 POF1B HOXC13 SYNE2

1.44e-0518612562913b5fd0617d024d600ba7015ec7b1961dade83
ToppCelldroplet-Liver-Hepatocytes-24m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SELP NTF3 FAM171A1 SYCP2 CALCRL IL6ST

1.44e-05186125690d53c2597a9f3a2b39afba75adfc54f1ca0a4db
ToppCellT_cells-ISG-high_CD4+_T_cells|World / Immune cells in Kidney/Urine in Lupus Nephritis

BCL2L14 DYNLT1 SAMD9L SYNE2 TAP1 IL6ST

1.53e-0518812566f8946d4710f6e32c937213f99b790b098b8819c
ToppCell10x5'-blood-Lymphocytic_T_CD8-Trm/em_CD8|blood / Manually curated celltypes from each tissue

SYNE1 FCRL3 CXCR6 SYNE2 TAP1 CLEC2B

1.62e-051901256e1f474dc36bf9eaf457b14a8761d287904754cdc
ToppCellCOVID-19-kidney-Stressed_EC|kidney / Disease (COVID-19 only), tissue and cell type

SELP CTNNB1 CALCRL HSP90AA1 CLEC2B HSP90AB1

1.67e-051911256d35aa842b813ea0eff7362abc894cca4e86b2fb2
ToppCellControl-Multiplet-Multiplet|World / Disease state, Lineage and Cell class

SYNE1 SPTBN1 F3 NECAB1 YAP1 SYNE2

1.72e-0519212561bfd022d5b87cf8a5d5069f559339a553a52a0a2
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-papillary_tips_cell-Papillary_Tip_Epithelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

BCL2L14 F3 POF1B MUC4 MUC5AC CLEC2B

1.72e-051921256612be3f861bd2f71a31c57f48c8b10930c3471ea
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-papillary_tips_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

BCL2L14 F3 POF1B MUC4 MUC5AC CLEC2B

1.72e-051921256f627a3f43e2340c8ba502211940171f25c7ff436
ToppCellPBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c03-ITGA4|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)

WWP1 SPTAN1 SPTBN1 ARHGAP5 SYNE2 IL6ST

1.77e-051931256194b49c152e3e3f599068ec88a7f0af6427b743a
ToppCellRV-10._Endothelium_II|World / Chamber and Cluster_Paper

SELP SPTBN1 NECAB1 SYNE2 CALCRL IL6ST

1.77e-0519312562531266bc57339d4e2b22a88817008e32b8c1598
ToppCelldroplet-Tongue-TONGUE-1m-Epithelial-suprabasal|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYO5B NTF3 F3 POF1B HOXC13 SYNE2

1.82e-051941256a3adcdc8b87332e8beb9bcd70cf36424af10633d
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

NID2 RELN SYNE1 F3 NECAB1 PALLD

1.82e-0519412561374600957c7d7f0b05fd2c1186f521b9096d4ef
ToppCellCOVID_non-vent-Lymphocytic-T_cell-CD4+_Memory_T_cell|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

WWP1 SPTAN1 SPTBN1 SYNE2 IL6ST HSP90AB1

1.88e-05195125622191d361af136942508f1553ff41a626ed982ad
ToppCellCOPD-Multiplet-Multiplet|COPD / Disease state, Lineage and Cell class

SYNE1 SPTBN1 F3 YAP1 SYNE2 MUC4

1.93e-051961256af4cdc61830685a888a1209826c23bcf54a43084
ToppCellCOVID-19-lung-Capillary_Aerocytes|COVID-19 / Disease (COVID-19 only), tissue and cell type

NCOA3 BTNL8 SYNE1 SPTBN1 SYNE2 CALCRL

1.93e-05196125649cc0a2b9739abad61dff7292ea0b14d28ff35c4
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SELP RELN SYNE1 SPTBN1 FAM171A1 CALCRL

1.93e-0519612568f2031b1a9232c389517fbf3c29f47f9468b0077
ToppCellMild-CD4+_T_activated|Mild / Disease group and Cell class

BCL2L14 DYNLT1 SAMD9L CTSB TAP1 IL6ST

1.93e-051961256daa1c3322d81e649161e889e1d78451d2d425d09
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Endothelial|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SELP RELN SYNE1 SPTBN1 FAM171A1 CALCRL

1.93e-05196125648b4a9cea97a55190217deaf51bf867608c5a9a7
ToppCellCOPD-Multiplet|COPD / Disease state, Lineage and Cell class

SYNE1 SPTBN1 F3 YAP1 SYNE2 MUC4

1.93e-0519612566d02d494196e3f857d53eea46d9419690d43beca
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SELP RELN SYNE1 SPTBN1 FAM171A1 CALCRL

1.93e-051961256473980c827443464d08a0be28c53e3536369b12a
ToppCellfacs-Limb_Muscle-ForelimbandHindlimb-3m|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TPP2 SPTBN1 STAT3 ACKR3 CTNNB1 IL6ST

1.93e-051961256151f1a29a91f8b234e9b6ed062666357a2f69128
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d14-21-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c03-GZMK|Severe-critical_convalescent_d14-21 / Compartment, severity and other cell annotations on 10x 3' data (130k)

SYNE1 SAMD9L FCRL3 SYNE2 TAP1 CLEC2B

1.93e-05196125617f17edadafdad9f24e88d708d7e1c765503131c
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

NID2 RELN SYNE1 F3 NECAB1 PALLD

1.93e-051961256545d2e4469924d333e3f655f559c899fa1260196
ToppCellCOVID_non-vent-Lymphocytic|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

SYNE1 SPTAN1 SPTBN1 FCRL3 SYNE2 HSP90AB1

1.99e-051971256c672915f8c8c1e948d251f6eaf9f84a5600c1193
ToppCellT_cells-Treg_cells|T_cells / Immune cells in Kidney/Urine in Lupus Nephritis

KLHL6 SELP BTNL8 ARHGAP5 FCRL3 IL6ST

1.99e-051971256ec9398ae3577f61d6b1e6aba50ef4261aaaa7610
ToppCellT_cells-Treg_cells|World / Immune cells in Kidney/Urine in Lupus Nephritis

SELP BTNL8 SPTAN1 FCRL3 SYNE2 IL6ST

1.99e-051971256de5448fcdf4e433fc167496413abe5d0c8a5c6d8
ToppCell3'-Adult|3' / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NXPE1 CTNNB1 MUC4 IQGAP3 CA1 HSP90AA1

2.04e-051981256302adb42089ff22fffc4f01af572ca2e151f7ce7
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

NCOA3 BTNL8 SYNE1 SPTBN1 CALCRL IL6ST

2.04e-05198125692416e65a0dc1a4bf931833407620ea05d362f56
ToppCellsevere-Myeloid-Neutrophils_4|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

KLHL2 NECAB1 SYNE2 IQSEC1 PYGL CA1

2.10e-05199125650242666def13e5d4149c563ae000d6768f086f7
ToppCellVE-CD4-antiviral_CD4|VE / Condition, Cell_class and T cell subcluster

BCL2L14 PSMA5 DYNLT1 SAMD9L SYNE2 TAP1

2.10e-051991256056a0538ca5e825ae6195b4c76c208708a014533
ToppCellcontrol-Epithelial|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

DYNLT1 F3 ARHGAP5 CTSB MUC4 PALLD

2.16e-052001256f95bbb94e51ac28b1995026c599ec3a34e012916
ToppCellLPS_IL1RA_TNF-Endothelial-Endothelial-Vein|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

SELP RALGAPA1 SPTAN1 FAM171A1 SYNE2 CALCRL

2.16e-0520012567eb366b2c5394af7c77650bde6261e7dac67154e
ToppCellLPS_only-Endothelial-Endothelial-Activated_Alv_Cap|LPS_only / Treatment groups by lineage, cell group, cell type

SPTAN1 SPTBN1 SAMD9L SYNE2 CALCRL TAP1

2.16e-052001256edb64556b3fefe3144f73b6efe23b9ffd34091d2
ToppCellLPS_IL1RA_TNF-Endothelial-Endothelial-Activated_Alv_Cap|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

SPTAN1 SPTBN1 SAMD9L SYNE2 CALCRL TAP1

2.16e-05200125689821a264e872ed53e08e9d3609d5cc5c314503e
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Epithelial-Epithelial,_Airway-squamous_epithelial_cell|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

MYO5B SPTBN1 F3 ARHGAP5 YAP1 MUC4

2.16e-0520012561c02a7f4047d1d2208cc522c6bb4a4989d7845bb
ToppCellLPS_IL1RA-Endothelial-Endothelial-Activated_Alv_Cap|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

NCOA3 SPTAN1 SPTBN1 SAMD9L SYNE2 CALCRL

2.16e-05200125679e51afb57ca38aacebd0298e5e727b55c0cfff9
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Epithelial-Epithelial,_Airway-squamous_epithelial_cell-Epi-Squamous|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

MYO5B SPTBN1 F3 ARHGAP5 YAP1 MUC4

2.16e-05200125603051d2190244208905e1611019d4b8fd200bae0
ToppCellCOVID-19-kidney-Technical/muscle|kidney / Disease (COVID-19 only), tissue and cell type

RELN NXPH1 FNDC7 EXO1 ROBO2

6.15e-0514812550dbd87078f54ee1c2f8ec64e8bac9dfddb9c181e
ToppCellSmart-seq2-lymph_node_(Smart-seq2)-myeloid-myeloid_monocytic-classical_monocyte|lymph_node_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

RELN F3 HEPH CALCRL DHX34

7.42e-051541255c6ecc46b99a783373729f7fae0b23216148ffb78
ToppCellfacs-Pancreas-Exocrine-3m-Epithelial-nan|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYCP2 ALMS1 NECAB1 GLP1R MUC4

7.65e-051551255441fcb6d05364fc6f4973f0b973f1a80b573ce1f
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell__prolif|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

BTNL8 FNDC7 FCRL3 GLP1R CALCRL

7.65e-05155125559035d792c26d870a8b097939e97fa47859ba68c
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

BCL2L14 MYO5B F3 SLC16A12 MALRD1

8.63e-051591255e6ff9d2bce62bf9ea173af80b688eeb40fa4ea4c
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c06-NR4A2|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

MYO5B SPTBN1 STAT3 DHX9 SYNE2

9.42e-05162125580317c4253bf8e897782e562f29835f181c65b98
ToppCell10x5'-blood-Lymphocytic_T_CD4-T_CD4/CD8|blood / Manually curated celltypes from each tissue

RALGAPA1 SPTBN1 STAT3 SYNE2 IL6ST

9.42e-051621255b4535bcb3f469bc139e73f1122f4070013e5a1de
ToppCellmetastatic_Lymph_Node-Myeloid_cells-Pleural_Mac|Myeloid_cells / Location, Cell class and cell subclass

KIF1A NXPH1 DYNLT1 SAMD9L TAP1

9.98e-051641255362c16ed7fb37bf16601fd5e059d3f3e2ed692b4
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_vein-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

SELP NTF3 FAM171A1 CALCRL IL6ST

1.09e-041671255d7fe24cdc4b55a9555ce9e20699f5036b88148e9
ToppCelldroplet-Lung-LUNG-30m-Myeloid-dendritic_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BCL2L14 FNDC7 ALMS1 LY75 IQGAP3

1.12e-0416812550e8b0e6399c6c82c9c0e546f7316f902de0765d3
ToppCellPND14-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SELP FAM171A1 ACKR3 CALCRL IL6ST

1.15e-04169125558136b8a0bf2dab45c91a053ef7225ea49ccb871
ToppCellPND14-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_mature|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SELP FAM171A1 ACKR3 CALCRL IL6ST

1.15e-04169125504c6ed38e1d1befba5ef5f37a3c1e045a0b163d6
ToppCell343B-Myeloid-Dendritic-cDC_activated|Dendritic / Donor, Lineage, Cell class and subclass (all cells)

BCL2L14 CALCRL LY75 MED12 IGSF3

1.15e-041691255e68e6c24606fd46eca6f86bb63fa86ea17879ae2
ToppCell3'_v3-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8|lymph-node_spleen / Manually curated celltypes from each tissue

RALGAPA1 SYNE1 STAT3 SYNE2 IL6ST

1.21e-0417112552e9a20f8980b78325c52065a9c14ab3656267c05
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell_prolif|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SELP RELN SYNE1 FAM171A1 CALCRL

1.25e-041721255c056d44e2e130ceccadfcdceb192a7f095d779c8
ToppCell3'-Child04-06-SmallIntestine-Endothelial-lymphatic_endothelial-LEC1_(ACKR4+)|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RELN AOC2 FAM151B CALCRL IL6ST

1.28e-04173125585083b9ce20351dd69aa2327ad087b848b4307ff
ToppCell5'-Adult-LargeIntestine-Endothelial-lymphatic_endothelial-LEC3_(ADGRG3+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NID2 RELN SPTBN1 ACKR3 CALCRL

1.28e-0417312557dc988fc0ba29990567bf1bcdeb3faeeee507eb1
ToppCellBasal_cells-Cryobiopsy_01|World / lung cells shred on cell class, cell subclass, sample id

POF1B FAM171A1 PRDM10 PKD1 TXNRD3

1.32e-041741255a0060be3940043015dcc49a5157de5541aed24a1
ToppCellTCGA-Brain-Primary_Tumor-Low_Grade_Glioma|TCGA-Brain / Sample_Type by Project: Shred V9

ZCCHC24 KIF1A SYNE1 SPTAN1 FAM171A1

1.43e-041771255e8ab340b20cd41554c3841fe980e078e878af35f
ToppCellTCGA-Ovary-Primary_Tumor-Ovarian_Carcinoma-Serous_Cystadenocarcinoma-6|TCGA-Ovary / Sample_Type by Project: Shred V9

ZCCHC24 KIF26B SYNE1 HEPH PALLD

1.46e-041781255142879e9393e721f9b05a6bb46995c9d6d713c95
ToppCellfacs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RAD51AP2 NECAB1 GLP1R ULK4 MUC4

1.46e-041781255fcbbcc44271515de1969b4732b6441c012693d5f
ToppCell10x3'2.3-week_17-19-Lymphocytic_NK-T_NK|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

RALGAPA1 ATAD3B FCRL3 CXCR6 CLEC2B

1.54e-0418012550a98d21fec67a890e75ebf0e2d23adddd77da214
ToppCell10x3'2.3-week_17-19-Lymphocytic_NK|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

RALGAPA1 ATAD3B FCRL3 CXCR6 CLEC2B

1.54e-0418012551c8398342d3fa4d5ca9a8a63626cc497c5291446
ToppCell10x3'2.3-week_17-19-Lymphocytic_NK-T_NK-CD56_bright_NK|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

RALGAPA1 ATAD3B FCRL3 CXCR6 CLEC2B

1.54e-041801255ddbab26b05f057bd78b78773381cd447bd2e2726
ToppCellEndothelial-A-HP_01|World / lung cells shred on cell class, cell subclass, sample id

SELP HEPH FAM171A1 CALCRL ZNF99

1.54e-0418012554c3376169770ee9f9283daae44c17f35e46bfd19
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

NID2 RELN KIF26B SYNE1 PALLD

1.58e-0418112555f2d3a08577c440c944778d07aa993c6e7873f3d
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

NID2 RELN KIF26B SYNE1 PALLD

1.58e-041811255c7c5f7d4c397b4613c772413a0a679377efffff3
ToppCellPBMC-Mild-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

SPTAN1 SPTBN1 SAMD9L SYNE2 IL6ST

1.62e-0418212551aea96ee211f7b9caef7fd385233f51be6021a73
ToppCelldroplet-Marrow-nan-3m-Hematologic-nan|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPTBN1 DHX9 SAMD9L CXCR6 LY75

1.62e-041821255e78ba2c5cae480c16a596ce7c3bf2d480becacf4
ToppCelldroplet-Marrow-nan-3m-Hematologic|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPTBN1 DHX9 SAMD9L CXCR6 LY75

1.62e-0418212551710eab3037a87609d21838be2d2d29c3bc36651
ToppCellPBMC-Mild-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

SPTAN1 SPTBN1 SAMD9L SYNE2 IL6ST

1.62e-041821255b427e43ee523a3ea9eca3207f3d82042f10f022a
ToppCell5'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating-Lymphatic_EC_differentiating_L.2.5.1.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

NID2 RELN SPTBN1 CALCRL IL6ST

1.62e-04182125553c267ee327e116dbd89d5927ed3bdf78d25ee62
ToppCellPBMC-Mild-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SPTAN1 SPTBN1 SAMD9L SYNE2 IL6ST

1.62e-041821255c0f63cfc67d61c0877b7acb2946dfb35aae8a8f5
ToppCellPBMC-Mild-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SPTAN1 SPTBN1 SAMD9L SYNE2 IL6ST

1.62e-0418212554cb182ef39be2044a6ad7266f332d4177591e550
ToppCell367C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_1|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

SYNE1 FAM171A1 SYNE2 HSP90AA1 CLEC2B

1.67e-041831255983ca1342ddd365e1f1df32a456394b002b10e41
ToppCellCOVID-19-Epithelial_cells-ECM-high_epithelial|COVID-19 / group, cell type (main and fine annotations)

SPTBN1 F3 YAP1 ROBO2 HSP90AA1

1.67e-041831255dc1d380bf7564f290256cb7108063d1bd2da732b
ToppCellCOVID-19_Mild-Lymphoid_T/NK-CD4+_T_activated|COVID-19_Mild / Disease group, lineage and cell class

SPTAN1 SPTBN1 SAMD9L SYNE2 IL6ST

1.67e-0418312557717fce227b4e02ed41baad8ae7dd2e22bd7c13e
ToppCellCOPD-Epithelial-ATII|World / Disease state, Lineage and Cell class

SYNE1 F3 NECAB1 YAP1 IGSF3

1.67e-0418312558e9aab4eeec2e282c2cab9bfca6dbf40d660c7b9
ToppCelldroplet-Kidney-nan-18m|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPTBN1 CUBN ARHGAP5 SAMD9L CTSB

1.71e-041841255e02859bbac36dbbd55d7ae8cb5e46b764d7c6381
ToppCellLPS_only-Epithelial_alveolar-AT_1-AT1|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

BCL2L14 KIF1A MYO5B F3 RRP9

1.75e-0418512550c247a3f394c42e2a6f67fee3d9cf33096fecd13
ToppCell5'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

NID2 RELN SPTBN1 CALCRL IL6ST

1.80e-04186125540070d9cd20188ba49b32acfca9bc16256b38bf5
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L3-5_SST_MAFB|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RELN MYO5B KIF26B NXPH1 ROBO2

1.80e-04186125596f6603cc75fa1ffc2a2fdb94ec0ec09498e540a
Drugglycine ethyl ester

AOC2 TGM4 AGL PYGL CA1

2.76e-07261255CID000012175
DrugNaringin hydrate [11032-30-7]; Up 200; 6.6uM; HL60; HT_HG-U133A

NTF3 SPTBN1 DBH PPP2R5B GLP1R CALCRL MMP26 MUC4 CA1

1.34e-0619512592425_UP
DrugNSC330499

HSP90AA1 HSP90AA2P HSP90AB1

5.56e-0671253CID000433447
Drugphenyldichloroarsine

HSP90AA1 HSP90AA2P HSP90AB1

8.87e-0681253CID000012762
Druginulin

SEMG2 F3 AGL PYGL CTNNB1 MUC4 MUC5AC

8.91e-061331257CID000024763
Drug5,8-quinolinedione

HSP90AA1 HSP90AA2P HSP90AB1

1.32e-0591253CID000388306
Drugboceprevir

AOC2 HSP90AA1 HSP90AA2P

1.32e-0591253CID010324367
DrugClozapine [5786-21-0]; Down 200; 12.2uM; MCF7; HT_HG-U133A

ZCCHC24 NTF3 SPTBN1 AOC2 SIM2 GLP1R DHX34 IL6ST

1.45e-0519912585265_DN
DrugPU-6

F3 HSP90AA1 HSP90AA2P

1.88e-05101253CID000448968
Drugn-C6

CTSB HSP90AA1 HSP90AA2P

1.88e-05101253CID006420120
Drug1 MZ

SYNE1 CA1 IGSF3

1.88e-05101253CID000444235
DrugPu-3

HSP90AA1 HSP90AA2P HSP90AB1

2.58e-05111253CID000448965
DrugI-hu

PYGL HSP90AA1 HSP90AA2P

2.58e-05111253CID009547901
Drug3-amino-5-chlorobenzoic acid

HSP90AA1 HSP90AA2P

2.99e-0521252CID010986726
Drugmonocillin III

HSP90AA1 HSP90AA2P

2.99e-0521252CID006478910
Drugpochonin A

HSP90AA1 HSP90AA2P

2.99e-0521252CID006478909
DrugPU-H71

HSP90AA1 HSP90AA2P

2.99e-0521252CID009549213
Drug9-Butyl-8-(3,4,5-Trimethoxybenzyl)-9h-Purin-6-Amine

HSP90AA1 HSP90AB1

2.99e-0521252DB02754
Drug1uyc

HSP90AA1 HSP90AA2P

2.99e-0521252CID000448969
DrugPU-9

HSP90AA1 HSP90AA2P

2.99e-0521252CID000448971
DrugP u 0

HSP90AA1 HSP90AA2P

2.99e-0521252CID000448974
Drug2qf6

HSP90AA1 HSP90AA2P

2.99e-0521252CID013373715
DrugGeldanamycin

HSP90AA1 HSP90AB1

2.99e-0521252DB02424
DrugCHEBI:42139

HSP90AA1 HSP90AA2P

2.99e-0521252CID011562562
Drug2qfo

HSP90AA1 HSP90AA2P

2.99e-0521252CID000600769
Drug3eko

HSP90AA1 HSP90AA2P

2.99e-0521252CID011160307
Drug8-(6-BROMO-BENZO[1,3]DIOXOL-5-YLSULFANYL)-9-(3-ISOPROPYLAMINO-PROPYL)-ADENINE

HSP90AA1 HSP90AB1

2.99e-0521252DB07877
Drug1uyi

HSP90AA1 HSP90AA2P

2.99e-0521252CID005289232
Drug4-[4-(2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)-3-METHYL-1H-PYRAZOL-5-YL]-6-ETHYLBENZENE-1,3-DIOL

HSP90AA1 HSP90AB1

2.99e-0521252DB07594
DrugNSC683666

HSP90AA1 HSP90AA2P

2.99e-0521252CID005469153
DrugH 64

HSP90AA1 HSP90AA2P

2.99e-0521252CID006914564
DrugSureCN4151355

HSP90AA1 HSP90AA2P

2.99e-0521252CID015942101
DrugCoal Tar

KLHL6 KIF26B SPTAN1 SPTBN1 TULP4 ACKR3 SYNE2 EXO1 ROBO2 IQGAP3

3.06e-0536012510ctd:D003033
Drugsteroid D

SERPINA6 HSP90AA1 HSP90AA2P

4.44e-05131253CID000454475
DrugAdenosine-5'-Diphosphate

KIF1A TAP1 HSP90AA1 HSP90AB1

4.45e-05361254DB03431
DrugFLT3 inhibitor

CTNNB1 HSP90AA1 HSP90AA2P

5.63e-05141253CID001048845
DrugAC1L9PMA

HSP90AA1 HSP90AA2P HSP90AB1

7.00e-05151253CID000451405
DrugAC1L1DW2

PSMA5 SPTBN1 CTNNB1 CTSB HSP90AA1 HSP90AA2P HSP90AB1

7.68e-051861257CID000002532
DrugAG-1478; Down 200; 31.6uM; MCF7; HT_HG-U133A_EA

TBC1D9B AVL9 DHX9 PRDM10 ALMS1 GEMIN4 IGSF3

7.95e-0518712571141_DN
Drugtropylium

SYNE1 SERPINA6 F3

8.59e-05161253CID000011000
Drugtungstopterin

MCPH1 AOC2 F3 TGM4 PKD1 CTNNB1

8.67e-051311256CID005460240
DrugGabazine [105538-73-6]; Down 200; 10.8uM; MCF7; HT_HG-U133A

PAPPA2 AVL9 CRAT SYCP2 ALMS1 SMARCD3 IL6ST

8.78e-0519012573253_DN
Drugpochonin D

HSP90AA1 HSP90AA2P

8.94e-0531252CID006478913
Drugazaquinone

HSP90AA1 HSP90AA2P

8.94e-0531252CID000099132
Drugbromoethyl acetate

SYNE1 F3

8.94e-0531252CID000013564
Drugd 1 v

HSP90AA1 HSP90AA2P

8.94e-0531252CID000683940
DrugAC1MD0RC

HSP90AA1 HSP90AA2P

8.94e-0531252CID002829073
Drug6-Chloro-1,3-dimethyluracil

SYNE1 F3

8.94e-0531252CID000081442
Drughydrazide 2

F3 CA1

8.94e-0531252CID000318174
DrugHM-9

HSP90AA1 HSP90AA2P

8.94e-0531252CID000433437
DrugGlyoxylspermidine

HSP90AA1 HSP90AA2P

8.94e-0531252CID000133564
Drugphosphorus pentachloride

SYNE1 CA1

8.94e-0531252CID000024819
Drugplakin

SYNE1 SPTAN1 SPTBN1 SYNE2 CTNNB1

8.96e-05821255CID000018752
DrugBetazole hydrochloride; Up 200; 27uM; HL60; HT_HG-U133A

RELN SPTAN1 PPP2R5B GLP1R IQSEC1 ZSCAN16 CTSB

9.07e-0519112571854_UP
DrugGlucose

SELP TPP2 KLHL2 KIF1A WWP1 SIM2 NKRF STAT3 FNDC7 TULP4 YAP1 AGL GLP1R EXO1 PYGL CTNNB1 CTSB IL6ST HSP90AA1 HSP90AB1

9.21e-05142012520ctd:D005947
DrugTrimethylcolchicinic acid [3482-37-9]; Up 200; 11.6uM; HL60; HT_HG-U133A

SELP NCOA3 MCPH1 SPTAN1 SPTBN1 PALLD IL6ST

9.37e-0519212572146_UP
DrugLY 294002; Up 200; 10uM; HL60; HT_HG-U133A

RALGAPA1 ZCCHC24 MCPH1 OSBPL7 IQSEC1 PALLD VPS13B

1.00e-0419412576195_UP
DrugMepenzolate bromide [76-90-4]; Up 200; 9.6uM; MCF7; HT_HG-U133A

MCPH1 CUBN CRAT PRDM10 CALCRL DHX34 MUC4

1.03e-0419512573829_UP
DrugCyclopenthiazide [742-20-1]; Up 200; 10.6uM; MCF7; HT_HG-U133A

TBL1Y SPTBN1 GIT2 SIM2 CRAT PPP2R5B GLP1R

1.03e-0419512574813_UP
DrugM40401

SELP HSP90AA1 HSP90AA2P

1.04e-04171253CID000503947
DrugKetanserin tartrate hydrate [83846-83-7]; Down 200; 7uM; HL60; HG-U133A

PAPPA2 BCL2L14 TBC1D9B GIT2 DHX9 ALMS1 RRP9

1.07e-0419612571593_DN
Drugalpha-estradiol; Up 200; 0.01uM; MCF7; HT_HG-U133A

ZCCHC24 RELN NTF3 GIT2 F3 PPP2R5B GEMIN4

1.10e-0419712571635_UP
DrugAminohippuric acid [61-78-9]; Up 200; 20.6uM; MCF7; HT_HG-U133A

SPTBN1 CRAT CXCR6 GLP1R SMARCD3 VPS13B CA1

1.10e-0419712575394_UP
DrugSulfameter [651-06-9]; Down 200; 14.2uM; MCF7; HT_HG-U133A

TPP2 KLHL2 AVL9 WWP1 GIT2 DCAF10 IL6ST

1.10e-0419712576212_DN
DrugDeltaline [6836-11-9]; Down 200; 7.8uM; MCF7; HT_HG-U133A

RALGAPA1 PAPPA2 SPTAN1 SPTBN1 SIM2 ALMS1 DHX34

1.10e-0419712576026_DN
DrugIodixanol [92339-11-2]; Up 200; 2.6uM; HL60; HT_HG-U133A

RALGAPA1 SEMG2 DBH ZZEF1 PPP2R5B DHX34 PALLD

1.14e-0419812573023_UP
DrugCarbetapentane citrate [23142-01-0]; Up 200; 7.6uM; PC3; HT_HG-U133A

KIF1A SYCP2 ALMS1 CXCR6 OSBPL7 MUC5AC MAP3K19

1.17e-0419912574649_UP
Drug(S)-(-)-Atenolol [93379-54-5]; Up 200; 15uM; MCF7; HT_HG-U133A

PAPPA2 SYNE1 CRAT KIAA0319 FAM171A1 CXCR6 MUC4

1.17e-0419912576444_UP
DrugTetracaone hydrochloride [136-47-0]; Up 200; 13.2uM; HL60; HG-U133A

NCOA3 BCL2L14 NTF3 SPTAN1 GIT2 CUBN FAM171A1

1.17e-0419912571739_UP
Drug(S)-(-)-Cycloserine [339-72-0]; Down 200; 39.2uM; MCF7; HT_HG-U133A

ZCCHC24 SIM2 F3 DHX34 MUC5AC VPS13B IL6ST

1.17e-0419912574346_DN
DrugAC1L3X9U

F3 TGM4 PYGL

1.24e-04181253CID000096811
DrugTMSOTf

SYNE1 F3 MUC4

1.47e-04191253CID000065367
Drugmant-GTP

SYNE1 STAT3 SYNE2 IL6ST

1.64e-04501254CID000128647
Drugbenz(a)anthracene

KLHL6 BCL2L14 KIF26B NTF3 SYNE1 SPTAN1 SPTBN1 AOC2 SAMD9L TULP4 CXCR6 NECAB1 SYNE2 DHX34 MUC4 TAP1 PALLD IGSF3

1.65e-04125112518ctd:C030935
Drugcompound 9b

SYNE1 HSP90AA1 HSP90AA2P

1.72e-04201253CID000207510
DrugCL-387,785

STAT3 HSP90AA1 HSP90AA2P

1.72e-04201253CID000002776
DrugNCI60_002052

IL6ST HSP90AA1 HSP90AA2P

1.72e-04201253CID006801032
Drugovalicin

SPTBN1 HSP90AA1 HSP90AA2P

1.72e-04201253CID000284995
Druggamma-Glutamylglutamate

CTSB HSP90AA1 HSP90AA2P

1.72e-04201253CID000092865
Drugdimethyl pimelimidate

HSP90AA1 HSP90AA2P HSP90AB1

1.72e-04201253CID000065403
DrugCGP7040

STAT3 HSP90AA1 HSP90AA2P

1.72e-04201253CID006436259
Drugwedelolactone

STAT3 HSP90AA1 HSP90AA2P

1.72e-04201253CID005281813
Drugzebularine

RELN TAP1 HSP90AA1 HSP90AA2P

1.77e-04511254CID000100016
Drugbutadiynyl

SYNE1 DBH

1.78e-0441252CID000521459
DrugN-(5-methylisoxazol-3-yl)-2-(4-(thiophen-2-yl)-6-(trifluoromethyl)pyrimidin-2-ylthio)acetamide

HSP90AA1 HSP90AB1

1.78e-0441252ctd:C576667
Druguranyl chloride

HSP90AA1 HSP90AA2P

1.78e-0441252CID000082259
Drugmethoxyhydroquinone

HSP90AA1 HSP90AA2P

1.78e-0441252CID000069988
Drug11p110

HSP90AA1 HSP90AA2P

1.78e-0441252CID002382787
Drugneotrehalose

YAP1 AGL PYGL TAP1 HSP90AA1 HSP90AA2P HSP90AB1

1.83e-042141257CID000001143
DrugUCS15A

CTNNB1 HSP90AA1 HSP90AA2P

2.00e-04211253CID005311041
Drugtamoxifen aziridine

HSP90AA1 HSP90AA2P HSP90AB1

2.31e-04221253CID003033894
DrugCCT018159

HSP90AA1 HSP90AA2P HSP90AB1

2.31e-04221253CID005327091
DiseaseMalignant neoplasm of breast

NCOA3 NID2 TBC1D9B SYNE1 SPTAN1 CUBN F3 STAT3 GPR180 FCRL3 YAP1 RRP9 SYNE2 EXO1 CTNNB1 MED12 VPS13B HSP90AA1

5.20e-07107412318C0006142
Diseasecancer (implicated_via_orthology)

HSP90AB4P PPP2R5B YAP1 CTNNB1 HSP90AA1 HSP90AA4P HSP90AA2P HSP90AB1

1.75e-052681238DOID:162 (implicated_via_orthology)
Diseaseotitis media (biomarker_via_orthology)

CTSB MUC4 MUC5AC

4.61e-05171233DOID:10754 (biomarker_via_orthology)
DiseaseAbnormality of the nervous system

ZSCAN16 PALLD

1.03e-0441232HP_0000707
DiseaseKi-1+ Anaplastic Large Cell Lymphoma

STAT3 HSP90AA1

1.03e-0441232C0206180
DiseaseFc receptor-like protein 3 measurement

FCRL3 CD5L

1.03e-0441232EFO_0008127
DiseaseAutosomal dominant Emery-Dreifuss muscular dystrophy

SYNE1 SYNE2

1.03e-0441232cv:CN293514
Diseaseneuromuscular disease (implicated_via_orthology)

ATAD3B ATAD3C

1.03e-0441232DOID:440 (implicated_via_orthology)
DiseaseAutosomal Recessive Emery-Dreifuss Muscular Dystrophy

SYNE1 SYNE2

1.71e-0451232C1450051
Diseasemucinous adenocarcinoma (is_marker_for)

MUC4 MUC5AC

1.71e-0451232DOID:3030 (is_marker_for)
DiseaseAutosomal Dominant Emery-Dreifuss Muscular Dystrophy (disorder)

SYNE1 SYNE2

1.71e-0451232C0410190
DiseaseEmery-Dreifuss muscular dystrophy

SYNE1 SYNE2

2.56e-0461232cv:C0410189
DiseaseMuscular Dystrophy, Emery-Dreifuss

SYNE1 SYNE2

2.56e-0461232C0410189
Diseasesolute carrier family 22 member 16 measurement

SELP MALRD1

2.56e-0461232EFO_0802079
DiseaseProstatic Neoplasms

NCOA3 STAT3 ROBO2 CTNNB1 CTSB MUC4 TAP1 MED12 IL6ST HSP90AB1

2.65e-0461612310C0033578
DiseaseMalignant neoplasm of prostate

NCOA3 STAT3 ROBO2 CTNNB1 CTSB MUC4 TAP1 MED12 IL6ST HSP90AB1

2.65e-0461612310C0376358
Diseasebiliary tract benign neoplasm (is_marker_for)

MUC4 MUC5AC

3.57e-0471232DOID:0050625 (is_marker_for)
DiseaseX-Linked Emery-Dreifuss Muscular Dystrophy

SYNE1 SYNE2

3.57e-0471232C0751337
DiseaseMammary Carcinoma, Human

NCOA3 SYNE1 F3 STAT3 YAP1 EXO1 CTNNB1 MED12 HSP90AA1

3.65e-045251239C4704874
DiseaseMammary Neoplasms, Human

NCOA3 SYNE1 F3 STAT3 YAP1 EXO1 CTNNB1 MED12 HSP90AA1

3.65e-045251239C1257931
DiseaseMammary Neoplasms

NCOA3 SYNE1 F3 STAT3 YAP1 EXO1 CTNNB1 MED12 HSP90AA1

3.76e-045271239C1458155
DiseaseBreast Carcinoma

NCOA3 SYNE1 F3 STAT3 YAP1 EXO1 CTNNB1 MED12 HSP90AA1

4.36e-045381239C0678222
Diseasecommon bile duct neoplasm (is_marker_for)

MUC4 MUC5AC

4.75e-0481232DOID:4608 (is_marker_for)
Diseaseovarian cancer (implicated_via_orthology)

YAP1 CTNNB1

4.75e-0481232DOID:2394 (implicated_via_orthology)
DiseaseUnipolar Depression

SELP RELN NTF3 DBH MED12 HSP90AA1

7.79e-042591236C0041696
DiseaseMyocardial Ischemia

SELP F3 CTNNB1 TAP1 IL6ST

8.74e-041761235C0151744
Diseaseselective IgA deficiency disease

ZCCHC24 FAM171A1 FCRL3

9.41e-04461233EFO_1001929
DiseaseColorectal Neoplasms

SYNE1 YAP1 ACKR3 EXO1 CTNNB1 IL6ST

1.10e-032771236C0009404
DiseaseEmery-Dreifuss muscular dystrophy (implicated_via_orthology)

SYNE1 SYNE2

1.11e-03121232DOID:11726 (implicated_via_orthology)
DiseaseAL amyloidosis

ULK4 SMARCD3

1.11e-03121232MONDO_0019438
Diseasepulmonary fibrosis (biomarker_via_orthology)

HSP90AB4P MUC5AC HSP90AB1

1.20e-03501233DOID:3770 (biomarker_via_orthology)
DiseaseFVC change measurement, response to placebo

RELN KIF1A

1.30e-03131232EFO_0008344, EFO_0010339
DiseaseN-acetylglutamine measurement

ALMS1 RRP9

1.30e-03131232EFO_0800017
Diseaseresponse to ketamine, dissociation measurement

ROBO2 HSP90AA4P

1.30e-03131232EFO_0009748, EFO_0009750
DiseaseDepressive disorder

SELP RELN DBH SERPINA6 STAT3 MED12

1.37e-032891236C0011581
DiseaseCarcinoma, Granular Cell

NCOA3 STAT3 CTNNB1 CA1

1.44e-031161234C0205644
DiseaseAdenocarcinoma, Tubular

NCOA3 STAT3 CTNNB1 CA1

1.44e-031161234C0205645
DiseaseAdenocarcinoma, Oxyphilic

NCOA3 STAT3 CTNNB1 CA1

1.44e-031161234C0205642
DiseaseCarcinoma, Cribriform

NCOA3 STAT3 CTNNB1 CA1

1.44e-031161234C0205643
DiseaseAdenocarcinoma, Basal Cell

NCOA3 STAT3 CTNNB1 CA1

1.44e-031161234C0205641
DiseaseAdenocarcinoma

NCOA3 STAT3 CTNNB1 CA1

1.44e-031161234C0001418
Diseaseneuroimaging measurement

BCL2L14 RELN MCPH1 KIF26B SPTBN1 NXPH1 F3 ACAD11 ACKR3 PKD1 ROBO2 CALCRL

1.73e-03106912312EFO_0004346
DiseaseProteinuria

CUBN FAM151B

1.75e-03151232HP_0000093
Diseaseresponse to cranial radiation therapy, short-term memory

MALRD1 ACKR3 HSP90AB1

2.03e-03601233EFO_0004335, EFO_0010950
Diseasepancreatic ductal carcinoma (is_marker_for)

MUC4 MUC5AC PALLD

2.13e-03611233DOID:3587 (is_marker_for)
DiseaseNeoplasm Metastasis

STAT3 YAP1 ACKR3 CTNNB1 HSP90AA1

2.20e-032171235C0027627
Diseaseovarian neoplasm

STAT3 YAP1 CTNNB1 IL6ST

2.43e-031341234C0919267
Diseasecholangiocarcinoma (is_marker_for)

OSBPL7 MUC4 MUC5AC

2.45e-03641233DOID:4947 (is_marker_for)
Diseasesyndrome (implicated_via_orthology)

ATAD3B ATAD3C

2.52e-03181232DOID:225 (implicated_via_orthology)
DiseaseAdrenocortical carcinoma

CTNNB1 MED12

2.52e-03181232C0206686
DiseaseMalignant neoplasm of ovary

STAT3 YAP1 CTNNB1 IL6ST

2.64e-031371234C1140680
Diseaseblood metabolite measurement

CRAT ALMS1

2.81e-03191232EFO_0005664
Diseasesuperior temporal gyrus volume measurement

NXPH1 CUBN

2.81e-03191232EFO_0010331
Diseaseintrahepatic cholangiocarcinoma (is_marker_for)

HSP90AA1 HSP90AB1

2.81e-03191232DOID:4928 (is_marker_for)
Diseasefasting blood insulin measurement

KIF26B NXPH1 MAP3K19

3.03e-03691233EFO_0004466
Diseaseglaucoma (is_marker_for)

HEPH MUC5AC

3.12e-03201232DOID:1686 (is_marker_for)
Diseaseatherosclerosis (biomarker_via_orthology)

SELP STAT3

3.12e-03201232DOID:1936 (biomarker_via_orthology)
Diseasecitrulline measurement

KIF26B CTSB

3.12e-03201232EFO_0009777
DiseaseMajor Depressive Disorder

RELN NTF3 DBH MED12 HSP90AA1

3.57e-032431235C1269683
DiseasePrimary microcephaly

MCPH1 CTNNB1

3.77e-03221232C0431350
Diseaseportal hypertension (biomarker_via_orthology)

DBH HSP90AA1

3.77e-03221232DOID:10762 (biomarker_via_orthology)
Diseaseidiopathic pulmonary fibrosis (is_marker_for)

F3 STAT3

4.12e-03231232DOID:0050156 (is_marker_for)
Diseaseserum non-albumin protein measurement

TPP2 F3 YAP1 OSBPL7 ULK4 MAP3K19

4.12e-033611236EFO_0004568

Protein segments in the cluster

PeptideGeneStartEntry
VFGTLYQVSKEHWNQ

PPP2R5B

401

Q15173
HSSVQSVNFVNYWQK

ERVK-18

381

O42043
VNYVNKRNTTWQAGH

CTSB

31

P07858
YLGVSHQWKSSEDNS

CXCR6

311

O00574
VASQSFQAGKHYWEV

BTNL8

331

Q6UX41
SILAVNYSHIWQKDQ

ADAM18

151

Q9Y3Q7
ASLDQNNSHFKVWNS

ALMS1

2631

Q8TCU4
TTQHTVSLNELWNKY

ALMS1

3591

Q8TCU4
GQRTLEYQDSHSQQW

BCL2L14

116

Q9BZR8
LTSNHRNSWAKAYNT

CRAT

251

P43155
TLYNNGANSIWEHSL

GIT2

66

Q14161
VEVKHQNQWYTVCQT

CD5L

151

O43866
STWTKQYQAAAHQDI

ACAD11

181

Q709F0
KDSIYNAVSIWSNVT

MMP26

121

Q9NRE1
QVVNVENWAHYNSST

RAD51AP2

716

Q09MP3
GSSNWIIQSHYEKVS

INTS9

221

Q9NV88
EESQSSSIYHQNDIW

AOC2

636

O75106
YSQLQKNSSWAEHLI

MUC4

4896

Q99102
AVSHWQQQSYLDSGI

CTNNB1

21

P35222
EQAAWRYSQTHQAIL

ESPNL

481

Q6ZVH7
ITKHNDDEQYAWESS

HSP90AB1

146

P08238
ATQSSLRHNAYVAAW

FAM171A1

231

Q5VUB5
ETQHDVWKYNSSINK

KLHL6

386

Q8WZ60
QVTHVIFKDGYQSTW

MCPH1

46

Q8NEM0
KDHKDQVTCVTYNWN

NEDD1

116

Q8NHV4
STAAQQHQWDGLLSY

GLP1R

206

P43220
QAYSKLSNSITVEWA

FNDC7

36

Q5VTL7
ITKHNDEEQYSWVSS

HSP90AB4P

121

Q58FF6
SKQTYHKEARNSWDS

IQSEC1

501

Q6DN90
SVAIQAHQYLDGTWS

KIF26B

306

Q2KJY2
SQVNKHWNRIADSDY

FBXW12

26

Q6X9E4
GHTSWVKNIEYDTNT

DCAF10

251

Q5QP82
AEITWYHAANHKAQT

FAM151B

31

Q6UXP7
WRSYVQIQNKSHSAS

NRDE2

1001

Q9H7Z3
QFNTQTALSWKEAYV

LY75

231

O60449
TSLYSQVHQIVNNWR

MED12

1501

Q93074
QAHWSNINDVYESSV

MED17

461

Q9NVC6
VENEKYAQHWCSQLT

MUC5AC

621

P98088
QNSSVQHTYLPSAWN

PRDM10

1026

Q9NQV6
KARVETQNHWFTYNE

PSMA5

91

P28066
AQEWLKLQQSSHGYS

GPR180

76

Q86V85
WSKSNYQVFQKVTDH

MED27

231

Q6P2C8
KHWNSQCKTSQTYVR

NTF3

211

P20783
TSSYQNLVWSDHSQE

POF1B

81

Q8WVV4
VHLYKNWINQTEAQT

IQGAP3

1076

Q86VI3
NQVKLEYSTNHGLTW

RELN

946

P78509
INCKVYNVSSWADRH

FADS2B

76

A8MWK0
ARLDVYTQWHQQSQS

PALLD

1321

Q8WX93
AINQTWSYRIHQNIT

NID2

691

Q14112
WTYNISTHSQWVKAD

MALRD1

376

Q5VYJ5
NSHDSTVIWRVLYNQ

MALRD1

756

Q5VYJ5
YNISWQLSVHQVHNS

PAPPA2

561

Q9BXP8
SNYQWTVNVNASHVV

CUBN

1876

O60494
SKDGQNWTSLYTHVD

HECTD1

1171

Q9ULT8
QTSQNSHFAVLWYVH

IGSF3

706

O75054
TRWKSHLQNYTVNAT

IL6ST

371

P40189
HSSVQSVNFVNDWQK

ERVK-24

381

P61566
HSSVQSVNFVNDWQK

ERVK-7

381

P61567
VAHWNSAKYSSLAEA

CA1

121

P00915
PKSVNVEQTDFHYNW

DHX36

871

Q9H2U1
DYGTTFVTAWKNTHN

AVL9

531

Q8NBF6
GNAYQHSKVNQWTTN

DYNLT1

31

P63172
LSWNVSYTQEAIHFQ

DBH

61

P09172
VWVNIQAKTTGYDTH

ACKR3

66

P25106
AQLAVSWQATAYASK

ATAD3C

356

Q5T2N8
HSFVQSVNFVNDWQK

ERVK-21

491

P61565
QVYCSKEQSQSAHLW

HOXC13

226

P31276
IYSQIWSIQHTKENS

FCRL3

661

Q96P31
SELTNQKEVAAWTYH

SELP

31

P16109
ITKHNDDEQYAWESS

HSP90AA1

151

P07900
ITKHNNDEQYAWESS

HSP90AA4P

91

Q58FG1
EAAQTYASHTQRWVV

DHX34

396

Q14147
WTNYTQCNVNTHEKV

CALCRL

121

Q16602
QDWATASRQINSYVK

SERPINA6

161

P08185
ITKHNDDEQYAWESS

HSP90AA2P

151

Q14568
KQESASSQTYQYWVH

MAP3K19

911

Q56UN5
TNYATVWASKTNLEQ

DHX9

746

Q08211
AVEVQDQKNGATHYW

KIF1A

786

Q12756
LNASNAVSWVSATYN

PKD1

1866

P98161
SALNLSISVHYWNNS

NXPE1

36

Q8N323
AKYWSSNVHEVQGAV

OSBPL7

676

Q9BZF2
EHTVNNSTAVISWTY

FNDC8

186

Q8TC99
SNVYQIQLSHSKEEW

TRMT44

231

Q8IYL2
QWSSHKVAFDKINSY

SYNE1

7131

Q8NF91
ESSQHTLNYWKEQSL

SYNE2

4961

Q8WXH0
NASAKHWTNFVITEN

NKRF

331

O15226
TQDYAQTAWIHSIVD

SLC16A12

81

Q6ZSM3
KTCYQEQTQSHVSWL

NXPH1

216

P58417
YFDKAQNTNSLWHSG

SAMD9L

1496

Q8IVG5
VAQDVFNHSWKTSAN

TAF1A

211

Q15573
NKSWYLEENVATHGS

HEPH

931

Q9BQS7
SLNDGQSWSQKRHYQ

NCOA3

306

Q9Y6Q9
HTQSRSAIVQALWQY

SMARCD3

276

Q6STE5
WVQSYATVVHNSRSS

SIM2

306

Q14190
NQKEAVAYAVNSWTT

TAP1

401

Q03518
VDINDHDWTRKSQQY

SEMG2

71

Q02383
HYNWQATLQNESGKE

TGM4

86

P49221
QTVRDYHATWKTVSN

ARHGAP5

281

Q13017
CQKSANVSSIWHRNY

EXO1

361

Q9UQ84
SIQNYHLECNETKSW

SPTBN1

956

Q01082
ILHQTQDSQVYWTVA

TBC1D9B

61

Q66K14
AQLAVSWQATAYASK

ATAD3B

531

Q5T9A4
WNSSKYNCSTQHADL

CLEC2B

56

Q92478
EKNNKQYCWHSSVVN

C12orf29

146

Q8N999
TQHNYLAQVTSNIWG

TULP4

591

Q9NRJ4
HEEAYNKLNQCWTTT

ZNF99

126

A8MXY4
DHVRNSSWAKNGSYQ

RALGAPA1

491

Q6GYQ0
HDRSVKVWNVAENSY

RRP9

261

O43818
QDWAYAASKESHATL

STAT3

41

P40763
KYTEHSTVGLAQQWD

SPTAN1

2281

Q13813
LSYFTTQSWKTAQQH

SYCP2

1381

Q9BX26
NEAVWKHNIIYVSSA

TPP2

346

P29144
QRYFLNHIDQTTTWQ

YAP1

186

P46937
NSWQTVANHVKTTLY

ROBO2

566

Q9HCK4
YQFDIAKQTWHIQSN

ROBO2

1176

Q9HCK4
SFDKYVHIWNTQSGS

TBL1Y

471

Q9BQ87
TNTVAAYNLTWKSTN

F3

36

P13726
HEGLQKNTSSWVLYN

TTC17

216

Q96AE7
IKAEDHYWGQDSSSQ

ZSCAN16

16

Q9H4T2
FQIGIYWANTNTVHK

VPS13B

3026

Q7Z7G8
VLHTWTKESAHNYEN

ZZEF1

1091

O43149
TKAIQNHISSLNWGY

TXNRD3

246

Q86VQ6
RVYFVNHNTKTTQWE

WWP1

471

Q9H0M0
WELTQKTFAYTNHTV

PYGL

366

P06737
KEYNKSWQTFHQDTI

ZNF583

156

Q96ND8
KNIVTFHEWYETSNH

ULK4

56

Q96C45
LNWVYLSLQDTHQAS

ZCCHC24

21

Q8N2G6
VVYNHTAANSKWIQE

AGL

216

P35573
TVISVWNSDTQNPYH

GEMIN4

271

P57678
AHSYNPSTNEWLQVA

KLHL42

271

Q9P2K6
SVEAYNIKSNEWFHV

KLHL2

416

O95198
NQSSDDHQIVLYEWS

KIAA0319

551

Q5VV43
DQNWAQKLYDRHSSS

MYO5B

521

Q9ULV0
ENSSVWNSHLQTNYS

NECAB1

306

Q8N987
WNSHLQTNYSKTFQR

NECAB1

311

Q8N987