Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ubiquitin binding	DDI2 TAB2 TAB3	3.56e-04	107	26	3	GO:0043130
GeneOntologyMolecularFunction	K63-linked polyubiquitin modification-dependent protein binding	TAB2 TAB3	5.20e-04	26	26	2	GO:0070530
GeneOntologyMolecularFunction	ubiquitin-like protein binding	DDI2 TAB2 TAB3	6.01e-04	128	26	3	GO:0032182
GeneOntologyMolecularFunction	polyubiquitin modification-dependent protein binding	TAB2 TAB3	2.67e-03	59	26	2	GO:0031593
GeneOntologyCellularComponent	supramolecular fiber	RIBC1 FBN1 KRT32 IFFO1 UNC45B HSPH1 NIN	4.55e-04	1179	26	7	GO:0099512
GeneOntologyCellularComponent	supramolecular polymer	RIBC1 FBN1 KRT32 IFFO1 UNC45B HSPH1 NIN	4.74e-04	1187	26	7	GO:0099081
Domain	CUE	TAB2 TAB3	3.90e-05	7	26	2	SM00546
Domain	CUE	TAB2 TAB3	5.19e-05	8	26	2	PF02845
Domain	CUE	TAB2 TAB3	8.33e-05	10	26	2	PS51140
Domain	CUE	TAB2 TAB3	8.33e-05	10	26	2	IPR003892
Domain	zf-RanBP	TAB2 TAB3	4.23e-04	22	26	2	PF00641
Domain	ZnF_RBZ	TAB2 TAB3	4.63e-04	23	26	2	SM00547
Domain	ZF_RANBP2_2	TAB2 TAB3	4.63e-04	23	26	2	PS50199
Domain	ZF_RANBP2_1	TAB2 TAB3	5.05e-04	24	26	2	PS01358
Domain	Znf_RanBP2	TAB2 TAB3	5.48e-04	25	26	2	IPR001876
Domain	Growth_fac_rcpt_	TMEM67 FBN1 KRT32	1.29e-03	156	26	3	IPR009030
Domain	ubiquitin	DDI2 IKBKB	1.94e-03	47	26	2	PF00240
Domain	Ubiquitin_dom	DDI2 IKBKB	2.94e-03	58	26	2	IPR000626
Domain	UBA-like	TAB2 TAB3	3.56e-03	64	26	2	IPR009060
Domain	Filament	KRT32 IFFO1	4.37e-03	71	26	2	SM01391
Domain	IF	KRT32 IFFO1	4.99e-03	76	26	2	IPR001664
Pathway	KEGG_MEDICUS_PATHOGEN_HIV_NEF_TO_TNF_NFKB_SIGNALING_PATHWAY	TAB2 IKBKB TAB3	1.19e-06	14	22	3	M47567
Pathway	KEGG_MEDICUS_PATHOGEN_HIV_GP120_TO_TNF_NFKB_SIGNALING_PATHWAY	TAB2 IKBKB TAB3	1.48e-06	15	22	3	M47566
Pathway	KEGG_MEDICUS_REFERENCE_TNF_NFKB_SIGNALING_PATHWAY	TAB2 IKBKB TAB3	1.82e-06	16	22	3	M47453
Pathway	REACTOME_TNFR1_INDUCED_NF_KAPPA_B_SIGNALING_PATHWAY	TAB2 IKBKB TAB3	1.75e-05	33	22	3	M27438
Pathway	REACTOME_TNFR1_INDUCED_NF_KAPPA_B_SIGNALING_PATHWAY	TAB2 IKBKB TAB3	1.75e-05	33	22	3	MM15180
Pathway	REACTOME_NOD1_2_SIGNALING_PATHWAY	TAB2 IKBKB TAB3	2.28e-05	36	22	3	M1059
Pathway	REACTOME_TAK1_DEPENDENT_IKK_AND_NF_KAPPA_B_ACTIVATION	TAB2 IKBKB TAB3	2.91e-05	39	22	3	MM15116
Pathway	REACTOME_TAK1_DEPENDENT_IKK_AND_NF_KAPPA_B_ACTIVATION	TAB2 IKBKB TAB3	4.19e-05	44	22	3	M852
Pathway	WP_INTERLEUKIN1_IL1_STRUCTURAL_PATHWAY	TAB2 IKBKB TAB3	5.80e-05	49	22	3	M39543
Pathway	WP_IL1_SIGNALING	TAB2 IKBKB TAB3	8.21e-05	55	22	3	M39346
Pathway	REACTOME_NUCLEOTIDE_BINDING_DOMAIN_LEUCINE_RICH_REPEAT_CONTAINING_RECEPTOR_NLR_SIGNALING_PATHWAYS	TAB2 IKBKB TAB3	8.67e-05	56	22	3	M1074
Pathway	REACTOME_TNF_SIGNALING	TAB2 IKBKB TAB3	8.67e-05	56	22	3	MM15453
Pathway	REACTOME_TNF_SIGNALING	TAB2 IKBKB TAB3	9.14e-05	57	22	3	M27713
Pathway	REACTOME_INTERLEUKIN_17_SIGNALING	TAB2 IKBKB TAB3	1.01e-04	59	22	3	MM15128
Pathway	REACTOME_IRAK2_MEDIATED_ACTIVATION_OF_TAK1_COMPLEX	TAB2 TAB3	1.04e-04	10	22	2	MM15647
Pathway	REACTOME_IRAK2_MEDIATED_ACTIVATION_OF_TAK1_COMPLEX	TAB2 TAB3	1.04e-04	10	22	2	M27925
Pathway	KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY	TAB2 IKBKB TAB3	1.18e-04	62	22	3	M15569
Pathway	REACTOME_ALPHA_PROTEIN_KINASE_1_SIGNALING_PATHWAY	TAB2 TAB3	1.27e-04	11	22	2	M29827
Pathway	REACTOME_TICAM1_TRAF6_DEPENDENT_INDUCTION_OF_TAK1_COMPLEX	TAB2 TAB3	1.27e-04	11	22	2	M27885
Pathway	KEGG_MEDICUS_PATHOGEN_EBV_LMP1_TO_NFKB_SIGNALING_PATHWAY	TAB2 IKBKB	1.27e-04	11	22	2	M47493
Pathway	REACTOME_ALPHA_PROTEIN_KINASE_1_SIGNALING_PATHWAY	TAB2 TAB3	1.27e-04	11	22	2	MM15668
Pathway	REACTOME_INTERLEUKIN_17_SIGNALING	TAB2 IKBKB TAB3	1.76e-04	71	22	3	M27382
Pathway	REACTOME_TRAF6_MEDIATED_INDUCTION_OF_TAK1_COMPLEX_WITHIN_TLR4_COMPLEX	TAB2 TAB3	2.75e-04	16	22	2	M1000
Pathway	REACTOME_MYD88_MAL_TIRAP_CASCADE_INITIATED_ON_PLASMA_MEMBRANE	TAB2 IKBKB TAB3	3.00e-04	85	22	3	MM14645
Pathway	KEGG_MEDICUS_REFERENCE_IL1_IL1R_P38_SIGNALING_PATHWAY	TAB2 TAB3	3.12e-04	17	22	2	M47470
Pathway	KEGG_MEDICUS_REFERENCE_TLR5_NFKB_SIGNALING_PATHWAY	TAB2 IKBKB	3.12e-04	17	22	2	M47912
Pathway	REACTOME_TRAF6_MEDIATED_INDUCTION_OF_TAK1_COMPLEX_WITHIN_TLR4_COMPLEX	TAB2 TAB3	3.12e-04	17	22	2	MM15648
Pathway	WP_TNFALPHA_SIGNALING	TAB2 IKBKB TAB3	3.79e-04	92	22	3	M39662
Pathway	REACTOME_CLEC7A_DECTIN_1_SIGNALING	TAB2 IKBKB TAB3	3.91e-04	93	22	3	MM15204
Pathway	KEGG_MEDICUS_REFERENCE_IL1_IL1R_JNK_SIGNALING_PATHWAY	TAB2 TAB3	3.91e-04	19	22	2	M47471
Pathway	KEGG_MEDICUS_REFERENCE_TLR1_2_4_NFKB_SIGNALING_PATHWAY	TAB2 IKBKB	4.34e-04	20	22	2	M47563
Pathway	REACTOME_TOLL_LIKE_RECEPTOR_9_TLR9_CASCADE	TAB2 IKBKB TAB3	4.70e-04	99	22	3	MM14660
Pathway	REACTOME_CLEC7A_DECTIN_1_SIGNALING	TAB2 IKBKB TAB3	4.84e-04	100	22	3	M27467
Pathway	REACTOME_JNK_C_JUN_KINASES_PHOSPHORYLATION_AND_ACTIVATION_MEDIATED_BY_ACTIVATED_HUMAN_TAK1	TAB2 TAB3	5.27e-04	22	22	2	M859
Pathway	WP_TOLLLIKE_RECEPTOR_SIGNALING	TAB2 IKBKB TAB3	5.27e-04	103	22	3	M39434
Pathway	REACTOME_INTERLEUKIN_1_SIGNALING	TAB2 IKBKB TAB3	5.42e-04	104	22	3	MM17224
Pathway	REACTOME_JNK_C_JUN_KINASES_PHOSPHORYLATION_AND_ACTIVATION_MEDIATED_BY_ACTIVATED_HUMAN_TAK1	TAB2 TAB3	5.77e-04	23	22	2	MM15134
Pathway	REACTOME_ACTIVATED_TAK1_MEDIATES_P38_MAPK_ACTIVATION	TAB2 TAB3	5.77e-04	23	22	2	M17243
Pathway	REACTOME_FCERI_MEDIATED_NF_KB_ACTIVATION	TAB2 IKBKB TAB3	5.89e-04	107	22	3	MM14915
Pathway	REACTOME_MYD88_INDEPENDENT_TLR4_CASCADE	TAB2 IKBKB TAB3	6.22e-04	109	22	3	M29565
Pathway	REACTOME_TOLL_LIKE_RECEPTOR_9_TLR9_CASCADE	TAB2 IKBKB TAB3	6.22e-04	109	22	3	M27012
Pathway	REACTOME_ACTIVATED_TAK1_MEDIATES_P38_MAPK_ACTIVATION	TAB2 TAB3	6.28e-04	24	22	2	MM15133
Pathway	REACTOME_C_TYPE_LECTIN_RECEPTORS_CLRS	TAB2 IKBKB TAB3	6.73e-04	112	22	3	MM15214
Pathway	REACTOME_INTERLEUKIN_1_SIGNALING	TAB2 IKBKB TAB3	7.09e-04	114	22	3	M27895
Pathway	REACTOME_TOLL_LIKE_RECEPTOR_TLR1_TLR2_CASCADE	TAB2 IKBKB TAB3	7.27e-04	115	22	3	M27013
Pathway	WP_TLR4_SIGNALING_AND_TOLERANCE	TAB2 IKBKB	8.57e-04	28	22	2	M39561
Pathway	REACTOME_TOLL_LIKE_RECEPTOR_4_TLR4_CASCADE	TAB2 IKBKB TAB3	8.64e-04	122	22	3	MM14640
Pathway	REACTOME_INTERLEUKIN_1_FAMILY_SIGNALING	TAB2 IKBKB TAB3	8.84e-04	123	22	3	MM15125
Pathway	REACTOME_SARS_COV_2_ACTIVATES_MODULATES_INNATE_AND_ADAPTIVE_IMMUNE_RESPONSES	TAB2 IKBKB TAB3	9.48e-04	126	22	3	M45009
Pathway	REACTOME_SARS_COV_2_INFECTION	ANO2 TAB2 IKBKB TAB3	1.07e-03	299	22	4	M41727
Pathway	REACTOME_FCERI_MEDIATED_NF_KB_ACTIVATION	TAB2 IKBKB TAB3	1.18e-03	136	22	3	M27207
Pathway	WP_TOLLLIKE_RECEPTOR_SIGNALING	TAB2 IKBKB	1.19e-03	33	22	2	MM15940
Pathway	REACTOME_NOD1_2_SIGNALING_PATHWAY	TAB2 TAB3	1.19e-03	33	22	2	MM14663
Pathway	PID_IL1_PATHWAY	TAB2 IKBKB	1.27e-03	34	22	2	M110
Pathway	REACTOME_C_TYPE_LECTIN_RECEPTORS_CLRS	TAB2 IKBKB TAB3	1.29e-03	140	22	3	M27484
Pathway	REACTOME_DEATH_RECEPTOR_SIGNALING	TAB2 IKBKB TAB3	1.34e-03	142	22	3	MM15431
Pathway	REACTOME_FC_EPSILON_RECEPTOR_FCERI_SIGNALING	TAB2 IKBKB TAB3	1.57e-03	150	22	3	MM14889
Pathway	REACTOME_INTERLEUKIN_1_FAMILY_SIGNALING	TAB2 IKBKB TAB3	1.63e-03	152	22	3	M899
Pathway	REACTOME_DEATH_RECEPTOR_SIGNALING	TAB2 IKBKB TAB3	1.69e-03	154	22	3	M27697
Pathway	REACTOME_TOLL_LIKE_RECEPTOR_CASCADES	TAB2 IKBKB TAB3	1.72e-03	155	22	3	MM14665
Pathway	REACTOME_TOLL_LIKE_RECEPTOR_CASCADES	TAB2 IKBKB TAB3	2.24e-03	170	22	3	M7494
Pathway	PID_TNF_PATHWAY	TAB2 IKBKB	2.31e-03	46	22	2	M128
Pathway	REACTOME_NUCLEOTIDE_BINDING_DOMAIN_LEUCINE_RICH_REPEAT_CONTAINING_RECEPTOR_NLR_SIGNALING_PATHWAYS	TAB2 TAB3	2.41e-03	47	22	2	MM14664
Pathway	REACTOME_FC_EPSILON_RECEPTOR_FCERI_SIGNALING	TAB2 IKBKB TAB3	2.89e-03	186	22	3	M27175
Pathway	WP_RANKLRANK_SIGNALING	TAB2 IKBKB	3.28e-03	55	22	2	M39667
Pathway	REACTOME_SARS_COV_2_HOST_INTERACTIONS	TAB2 IKBKB TAB3	3.75e-03	204	22	3	M45011
Pathway	WP_MIRNA_ROLE_IN_IMMUNE_RESPONSE_IN_SEPSIS	TAB2 IKBKB	4.56e-03	65	22	2	M39354
Pathway	REACTOME_SARS_COV_INFECTIONS	ANO2 TAB2 IKBKB TAB3	5.58e-03	471	22	4	M39009
Pathway	WP_JOUBERT_SYNDROME	TMEM67 NIN	6.18e-03	76	22	2	M39835
Pathway	WP_MAPK_SIGNALING	TAB2 IKBKB RASGRF1	6.33e-03	246	22	3	M39597
Pubmed	USP19 Inhibits TNF-α- and IL-1β-Triggered NF-κB Activation by Deubiquitinating TAK1.	TAB2 IKBKB TAB3	7.41e-09	6	26	3	31127032
Pubmed	CHIP promotes the activation of NF-κB signaling through enhancing the K63-linked ubiquitination of TAK1.	TAB2 IKBKB TAB3	2.07e-08	8	26	3	34535633
Pubmed	HIV-1 Vpr stimulates NF-κB and AP-1 signaling by activating TAK1.	TAB2 IKBKB TAB3	4.43e-08	10	26	3	24912525
Pubmed	The p38-interacting protein p38IP suppresses TCR and LPS signaling by targeting TAK1.	TAB2 IKBKB TAB3	6.09e-08	11	26	3	32410369
Pubmed	Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation.	TAB2 IKBKB TAB3	8.12e-08	12	26	3	19136968
Pubmed	Activation of the canonical IKK complex by K63/M1-linked hybrid ubiquitin chains.	TAB2 IKBKB TAB3	1.68e-07	15	26	3	23986494
Pubmed	LncRNA PCIR Is an Oncogenic Driver via Strengthen the Binding of TAB3 and PABPC4 in Triple Negative Breast Cancer.	TAB2 TAB3	5.37e-07	2	26	2	34012913
Pubmed	Whole Exome Sequencing, Familial Genomic Triangulation, and Systems Biology Converge to Identify a Novel Nonsense Mutation in TAB2-encoded TGF-beta Activated Kinase 1 in a Child with Polyvalvular Syndrome.	TAB2 TAB3	5.37e-07	2	26	2	27452334
Pubmed	Co-ordinated control of the ADP-heptose/ALPK1 signalling network by the E3 ligases TRAF6, TRAF2/c-IAP1 and LUBAC.	TAB2 IKBKB TAB3	5.66e-07	22	26	3	36098982
Pubmed	SPATA2 links CYLD to the TNF-α receptor signaling complex and modulates the receptor signaling outcomes.	TAB2 IKBKB TAB3	1.64e-06	31	26	3	27307491
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	RIBC1 TAB2 CNOT1 IFFO1 TAB3 HSPH1 NIN	2.28e-06	853	26	7	28718761
Pubmed	Tripartite motif 38 attenuates cardiac fibrosis after myocardial infarction by suppressing TAK1 activation via TAB2/3 degradation.	TAB2 TAB3	3.22e-06	4	26	2	35982795
Pubmed	NLRP6 facilitates the interaction between TAB2/3 and TRIM38 in rheumatoid arthritis fibroblast-like synoviocytes.	TAB2 TAB3	3.22e-06	4	26	2	28295271
Pubmed	Roles for TAB1 in regulating the IL-1-dependent phosphorylation of the TAB3 regulatory subunit and activity of the TAK1 complex.	TAB2 TAB3	3.22e-06	4	26	2	18021073
Pubmed	TAB3, a new binding partner of the protein kinase TAK1.	TAB2 TAB3	3.22e-06	4	26	2	14670075
Pubmed	Interleukin-1 and TRAF6-dependent activation of TAK1 in the absence of TAB2 and TAB3.	TAB2 TAB3	3.22e-06	4	26	2	28507161
Pubmed	Hepatitis B Surface Antigen Suppresses the Activation of Nuclear Factor Kappa B Pathway via Interaction With the TAK1-TAB2 Complex.	TAB2 TAB3	3.22e-06	4	26	2	33717111
Pubmed	Tripartite Motif-Containing 27 Attenuates Liver Ischemia/Reperfusion Injury by Suppressing Transforming Growth Factor β-Activated Kinase 1 (TAK1) by TAK1 Binding Protein 2/3 Degradation.	TAB2 TAB3	3.22e-06	4	26	2	32343849
Pubmed	G protein-coupled receptors activate p38 MAPK via a non-canonical TAB1-TAB2- and TAB1-TAB3-dependent pathway in endothelial cells.	TAB2 TAB3	3.22e-06	4	26	2	30760523
Pubmed	Structural basis for specific recognition of Lys 63-linked polyubiquitin chains by NZF domains of TAB2 and TAB3.	TAB2 TAB3	3.22e-06	4	26	2	19927120
Pubmed	Essential roles of K63-linked polyubiquitin-binding proteins TAB2 and TAB3 in B cell activation via MAPKs.	TAB2 TAB3	3.22e-06	4	26	2	23509369
Pubmed	TGFβ-activated kinase 1 (TAK1)-binding proteins (TAB) 2 and 3 negatively regulate autophagy.	TAB2 TAB3	5.37e-06	5	26	2	21976705
Pubmed	TAK1 is a ubiquitin-dependent kinase of MKK and IKK.	TAB2 IKBKB	5.37e-06	5	26	2	11460167
Pubmed	WDR34 is a novel TAK1-associated suppressor of the IL-1R/TLR3/TLR4-induced NF-kappaB activation pathway.	TAB2 TAB3	5.37e-06	5	26	2	19521662
Pubmed	The microRNA miR-23b suppresses IL-17-associated autoimmune inflammation by targeting TAB2, TAB3 and IKK-α.	TAB2 TAB3	5.37e-06	5	26	2	22660635
Pubmed	Mycobacterium tuberculosis suppresses innate immunity by coopting the host ubiquitin system.	TAB2 TAB3	8.05e-06	6	26	2	25642820
Pubmed	TRIM5 acts as more than a retroviral restriction factor.	TAB2 TAB3	8.05e-06	6	26	2	21866272
Pubmed	PKC phosphorylation of TRAF2 mediates IKKalpha/beta recruitment and K63-linked polyubiquitination.	TAB2 IKBKB	8.05e-06	6	26	2	19150425
Pubmed	TRIM30 alpha negatively regulates TLR-mediated NF-kappa B activation by targeting TAB2 and TAB3 for degradation.	TAB2 TAB3	8.05e-06	6	26	2	18345001
Pubmed	Antiviral immunity: TRIM5 moonlights as a pattern recognition receptor.	TAB2 TAB3	8.05e-06	6	26	2	21572451
Pubmed	TAK1 adaptor proteins, TAB2 and TAB3, link the signalosome to B-cell receptor-induced IKK activation.	IKBKB TAB3	8.05e-06	6	26	2	27497262
Pubmed	Immunology: TRIM5 does double duty.	TAB2 TAB3	8.05e-06	6	26	2	21512569
Pubmed	Herpesvirus tegument protein activates NF-kappaB signaling through the TRAF6 adaptor protein.	TAB2 IKBKB	8.05e-06	6	26	2	18682563
Pubmed	TRIM25 Promotes TNF-α-Induced NF-κB Activation through Potentiating the K63-Linked Ubiquitination of TRAF2.	TAB2 IKBKB	8.05e-06	6	26	2	32024699
Pubmed	RNF4 negatively regulates NF-κB signaling by down-regulating TAB2.	TAB2 TAB3	8.05e-06	6	26	2	26299341
Pubmed	Interleukin-1 (IL-1) induces the Lys63-linked polyubiquitination of IL-1 receptor-associated kinase 1 to facilitate NEMO binding and the activation of IkappaBalpha kinase.	TAB2 IKBKB	8.05e-06	6	26	2	18180283
Pubmed	Trim5 TAKes on pattern recognition.	TAB2 TAB3	8.05e-06	6	26	2	21575904
Pubmed	An F-box protein, FBXW5, negatively regulates TAK1 MAP3K in the IL-1beta signaling pathway.	TAB2 TAB3	1.13e-05	7	26	2	19232515
Pubmed	Cysteine methylation disrupts ubiquitin-chain sensing in NF-κB activation.	TAB2 TAB3	1.13e-05	7	26	2	22158122
Pubmed	Inhibition of autophagy by TAB2 and TAB3.	TAB2 TAB3	1.13e-05	7	26	2	22081109
Pubmed	Transforming growth factor beta-activated kinase 1 (TAK1) kinase adaptor, TAK1-binding protein 2, plays dual roles in TAK1 signaling by recruiting both an activator and an inhibitor of TAK1 kinase in tumor necrosis factor signaling pathway.	TAB2 TAB3	1.13e-05	7	26	2	19955178
Pubmed	Cyclophilin J limits inflammation through the blockage of ubiquitin chain sensing.	TAB2 TAB3	1.13e-05	7	26	2	30348973
Pubmed	Tumor necrosis factor receptor-associated factors (TRAFs)--a family of adapter proteins that regulates life and death.	TAB2 IKBKB	1.13e-05	7	26	2	9744859
Pubmed	TAK1-dependent signaling requires functional interaction with TAB2/TAB3.	TAB2 TAB3	1.13e-05	7	26	2	17158449
Pubmed	The TBK1 adaptor and autophagy receptor NDP52 restricts the proliferation of ubiquitin-coated bacteria.	IKBKB TAB3	1.50e-05	8	26	2	19820708
Pubmed	USP15 potentiates NF-κB activation by differentially stabilizing TAB2 and TAB3.	TAB2 TAB3	1.50e-05	8	26	2	31903660
Pubmed	Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO.	TAB2 IKBKB	1.93e-05	9	26	2	16603398
Pubmed	Smad7 binds to the adaptors TAB2 and TAB3 to block recruitment of the kinase TAK1 to the adaptor TRAF2.	TAB2 TAB3	1.93e-05	9	26	2	17384642
Pubmed	LUBAC regulates NF-κB activation upon genotoxic stress by promoting linear ubiquitination of NEMO.	TAB2 IKBKB	1.93e-05	9	26	2	21811235
Pubmed	TRIM5 is an innate immune sensor for the retrovirus capsid lattice.	TAB2 TAB3	1.93e-05	9	26	2	21512573
Pubmed	Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling.	TAB2 TAB3	1.93e-05	9	26	2	14633987
Pubmed	RBCK1 negatively regulates tumor necrosis factor- and interleukin-1-triggered NF-kappaB activation by targeting TAB2/3 for degradation.	TAB2 TAB3	1.93e-05	9	26	2	17449468
Pubmed	MD-2: the Toll 'gatekeeper' in endotoxin signalling.	TAB2 IKBKB TAB3	2.32e-05	74	26	3	15276183
Pubmed	TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway.	TAB2 TAB3	2.41e-05	10	26	2	10882101
Pubmed	A critical role of RICK/RIP2 polyubiquitination in Nod-induced NF-kappaB activation.	TAB2 TAB3	2.41e-05	10	26	2	18079694
Pubmed	Regulation and function of IKK and IKK-related kinases.	TAB2 IKBKB	2.94e-05	11	26	2	17047224
Pubmed	The germinal center kinase TNIK is required for canonical NF-κB and JNK signaling in B-cells by the EBV oncoprotein LMP1 and the CD40 receptor.	TAB2 IKBKB	2.94e-05	11	26	2	22904686
Pubmed	TRIM38 inhibits TNFα- and IL-1β-triggered NF-κB activation by mediating lysosome-dependent degradation of TAB2/3.	TAB2 TAB3	2.94e-05	11	26	2	24434549
Pubmed	MALT1-ubiquitination triggers non-genomic NF-κB/IKK signaling upon platelet activation.	TAB2 IKBKB	2.94e-05	11	26	2	25748427
Pubmed	USP10 inhibits genotoxic NF-κB activation by MCPIP1-facilitated deubiquitination of NEMO.	TAB2 IKBKB	2.94e-05	11	26	2	24270572
Pubmed	pp60(v-src) induction of cyclin D1 requires collaborative interactions between the extracellular signal-regulated kinase, p38, and Jun kinase pathways. A role for cAMP response element-binding protein and activating transcription factor-2 in pp60(v-src) signaling in breast cancer cells.	TAB2 TAB3	2.94e-05	11	26	2	10066798
Pubmed	Proteomic and Biochemical Comparison of the Cellular Interaction Partners of Human VPS33A and VPS33B.	EFR3B TAB2 CNOT1 NIN	3.49e-05	251	26	4	29778605
Pubmed	Deubiquitinase MYSM1 Regulates Innate Immunity through Inactivation of TRAF3 and TRAF6 Complexes.	TAB2 TAB3	3.53e-05	12	26	2	26474655
Pubmed	TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo.	TAB2 IKBKB	3.53e-05	12	26	2	16260493
Pubmed	RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.	EFR3B TAB2 CNOT1 TAB3	4.19e-05	263	26	4	34702444
Pubmed	Host E3 ligase HUWE1 attenuates the proapoptotic activity of the MERS-CoV accessory protein ORF3 by promoting its ubiquitin-dependent degradation.	DDI2 IDH3B HIBADH CNOT1 HSPH1	4.22e-05	534	26	5	35032548
Pubmed	Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction.	TAB2 IKBKB	5.61e-05	15	26	2	20005846
Pubmed	TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains.	TAB2 TAB3	6.41e-05	16	26	2	15327770
Pubmed	Poly(I-C)-induced Toll-like receptor 3 (TLR3)-mediated activation of NFkappa B and MAP kinase is through an interleukin-1 receptor-associated kinase (IRAK)-independent pathway employing the signaling components TLR3-TRAF6-TAK1-TAB2-PKR .	TAB2 TAB3	7.26e-05	17	26	2	12609980
Pubmed	K48- and K63-linked ubiquitin chain interactome reveals branch- and length-specific ubiquitin interactors.	DDI2 TAB2 IKBKB AXL TAB3	7.56e-05	604	26	5	38803224
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	EFR3B TAB2 ARHGAP39 CNOT1 TAB3 NIN	1.02e-04	1049	26	6	27880917
Pubmed	Association between anti-tumour necrosis factor treatment response and genetic variants within the TLR and NF{kappa}B signalling pathways.	TAB2 IKBKB	1.47e-04	24	26	2	20448286
Pubmed	BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.	EFR3B TAB2 ARHGAP39 CNOT1 HSPH1	1.59e-04	708	26	5	39231216
Pubmed	Holoprosencephaly Overview	CNOT1 DISP1	1.60e-04	25	26	2	20301702
Pubmed	BAG5 Promotes Alpha-Synuclein Oligomer Formation and Functionally Interacts With the Autophagy Adaptor Protein p62.	IDH3B CNOT1 HSPH1	2.13e-04	156	26	3	32850835
Pubmed	TBK1 and IKKε prevent TNF-induced cell death by RIPK1 phosphorylation.	TAB2 IKBKB	2.31e-04	30	26	2	30420664
Pubmed	A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.	TAB2 IKBKB TAB3	2.38e-04	162	26	3	14743216
Pubmed	A transition zone complex regulates mammalian ciliogenesis and ciliary membrane composition.	TMEM67 NIN	3.52e-04	37	26	2	21725307
Pubmed	An Interaction Landscape of Ubiquitin Signaling.	DDI2 TAB2 IKBKB TAB3	4.24e-04	481	26	4	28190767
Pubmed	Quantitative proteomics identifies a Dab2/integrin module regulating cell migration.	NT5E AXL	5.22e-04	45	26	2	19581412
Pubmed	The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis.	TAB2 ARHGAP39 TAB3	5.68e-04	218	26	3	33378226
Pubmed	Skp2-Mediated Stabilization of MTH1 Promotes Survival of Melanoma Cells upon Oxidative Stress.	IDH3B NT5E	6.96e-04	52	26	2	28947420
Interaction	EMILIN1 interactions	RIBC1 TAB2 PARS2 TAB3	8.82e-06	103	26	4	int:EMILIN1
Interaction	BICD1 interactions	RIBC1 TAB2 IFFO1 TAB3 NIN	1.50e-05	250	26	5	int:BICD1
Interaction	EGLN3 interactions	TAB2 ARHGAP39 IDH3B IKBKB CNOT1 IFFO1 PARS2 HSPH1 NIN	2.10e-05	1296	26	9	int:EGLN3
Interaction	TAB3 interactions	TAB2 IKBKB TAB3	8.26e-05	66	26	3	int:TAB3
Cytoband	12p13.3	ANO2 IFFO1	1.33e-04	30	26	2	12p13.3
Cytoband	8q24.3	RHPN1 ARHGAP39	1.88e-03	113	26	2	8q24.3
GeneFamily	Zinc fingers RANBP2-type \|RNA binding motif containing	TAB2 TAB3	1.34e-04	21	15	2	89
ToppCell	mLN-T_cell-Activated_CD4_T\|T_cell / Region, Cell class and subclass	TMEM67 EVI2A CNOT1 HSPH1	5.04e-06	198	26	4	404ec46bd39b6f4d02a03ef38c30850bbbd8b608
Disease	refractive error, self reported educational attainment	FBN1 RASGRF1	3.80e-04	34	25	2	EFO_0004784, MONDO_0004892
Disease	heart disease (implicated_via_orthology)	FBN1 CNOT1	4.75e-04	38	25	2	DOID:114 (implicated_via_orthology)
Disease	systemic lupus erythematosus (is_marker_for)	TAB2 TAB3	7.28e-04	47	25	2	DOID:9074 (is_marker_for)
Disease	electrocardiography	TAB2 CNOT1 AXL OR8B8	9.65e-04	530	25	4	EFO_0004327
Disease	rheumatoid arthritis (is_marker_for)	TAB2 TAB3	1.56e-03	69	25	2	DOID:7148 (is_marker_for)

Protein segments in the cluster

Peptide	Gene	Start	Entry
MCDQQNAFTMCPLCD	ANO2	401	Q9NQ90
CNSVDCQMPNMEANV	DISP1	1491	Q96F81
QLMDMVRCQQRNCIP	PAAT	206	Q9H8K7
ACMMGVTFCANNLVN	OR8B8	161	Q15620
NLAMVMAPNCLRCQS	ARHGAP39	1036	Q9C0H5
QRAAMMNLLRNNSCL	IKBKB	451	O14920
LAQMQCMITNVEAQL	KRT32	351	Q14532
NCLRLMNDMTAVALN	HSPH1	166	Q92598
AMEALDQLLMACHCQ	EFR3B	76	Q9Y2G0
CAENNNNMAMLICLI	EVI2A	126	P22794
CDVAQQRNCEDMIQM	IFFO1	341	Q0D2I5
ETMIIDNCCMQLVQN	IDH3B	246	O43837
CSIRNMCLNGMCINE	FBN1	576	P35555
QMTIMSQACAERCNI	DDI2	256	Q5TDH0
ANLTSCQALGNMCVM	TMEM67	241	Q5HYA8
NMETLDLSQMNCPAC	PARS2	281	Q7L3T8
CMLQNNNNLDACCAV	TAB2	31	Q9NYJ8
CMLQNNNNLEACCRA	TAB3	31	Q8N5C8
SQLQEQLMMLCADCD	NIN	1201	Q8N4C6
QCVDNIRCNGLMMNA	RASGRF1	581	Q13972
ASLCALEQLMMAQAQ	RHPN1	271	Q8TCX5
RECNMGNLICDAMIN	NT5E	356	P21589
QAAKICNNMLLAISM	HIBADH	206	P31937
VAQCCMGQKQAQQVM	CNOT1	2356	A5YKK6
QLRQAATECMCNMVL	UNC45B	776	Q8IWX7
MCAMANANKAQAAVQ	RIBC1	211	Q8N443
RNCMLNENMSVCVAD	AXL	676	P30530