Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionarmadillo repeat domain binding

LEF1 STRN TCF7L2

2.30e-089143GO:0070016
GeneOntologyMolecularFunctiongamma-catenin binding

LEF1 TCF7L2

3.00e-0512142GO:0045295
GeneOntologyMolecularFunctionbeta-catenin binding

LEF1 TCF7L1 TCF7L2

7.34e-05120143GO:0008013
GeneOntologyMolecularFunctionchromatin binding

LEF1 TCF7L1 CHD3 TCF7L2 ZFY

1.04e-04739145GO:0003682
GeneOntologyMolecularFunctionnuclear receptor binding

LEF1 STRN TCF7L2

2.73e-04187143GO:0016922
GeneOntologyMolecularFunctionDNA-binding transcription activator activity, RNA polymerase II-specific

LEF1 MEIS2 TCF7L2 ZFY

4.90e-04560144GO:0001228
GeneOntologyMolecularFunctionDNA-binding transcription activator activity

LEF1 MEIS2 TCF7L2 ZFY

5.10e-04566144GO:0001216
GeneOntologyMolecularFunctionnuclear estrogen receptor binding

LEF1 STRN

6.16e-0453142GO:0030331
GeneOntologyMolecularFunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding

LEF1 TCF7L1 MEIS2 TCF7L2 ZFY

1.16e-031244145GO:0000978
GeneOntologyMolecularFunctioncis-regulatory region sequence-specific DNA binding

LEF1 TCF7L1 MEIS2 TCF7L2 ZFY

1.28e-031271145GO:0000987
GeneOntologyMolecularFunctiontranscription factor binding

LEF1 STRN MEIS2 TCF7L2

1.48e-03753144GO:0008134
GeneOntologyMolecularFunctionDNA-binding transcription factor activity, RNA polymerase II-specific

LEF1 TCF7L1 MEIS2 TCF7L2 ZFY

2.05e-031412145GO:0000981
GeneOntologyMolecularFunctionRNA polymerase II transcription regulatory region sequence-specific DNA binding

LEF1 TCF7L1 MEIS2 TCF7L2 ZFY

2.37e-031459145GO:0000977
GeneOntologyMolecularFunctionprotein domain specific binding

LEF1 STRN TCF7L2 AKAP7

2.58e-03875144GO:0019904
GeneOntologyMolecularFunctionRNA polymerase II-specific DNA-binding transcription factor binding

LEF1 STRN TCF7L2

2.77e-03417143GO:0061629
GeneOntologyMolecularFunctionDNA-binding transcription factor binding

LEF1 STRN TCF7L2

7.05e-03582143GO:0140297
GeneOntologyMolecularFunctionhistone binding

LEF1 CHD3

1.44e-02265142GO:0042393
GeneOntologyBiologicalProcessmulticellular organism growth

ALMS1 RBBP6 TCF7L2 ZFY

1.89e-05249144GO:0035264
GeneOntologyCellularComponentbeta-catenin-TCF complex

LEF1 TCF7L1 TCF7L2

6.81e-0813143GO:1990907
GeneOntologyCellularComponentchromatin

LEF1 TCF7L1 CHD3 MEIS2 TCF7L2 ZFY IGFBP3

1.94e-051480147GO:0000785
GeneOntologyCellularComponenttranscription regulator complex

LEF1 TCF7L1 CHD3 TCF7L2

5.21e-04596144GO:0005667
GeneOntologyCellularComponentRNA polymerase II transcription regulator complex

LEF1 TCF7L1 TCF7L2

7.13e-04272143GO:0090575
GeneOntologyCellularComponentPML body

CHD3 TCF7L2

3.08e-03125142GO:0016605
DomainCTNNB1-bd_N

LEF1 TCF7L1 TCF7L2

1.34e-094143IPR013558
DomainTCF/LEF

LEF1 TCF7L1 TCF7L2

1.34e-094143IPR024940
DomainCTNNB1_binding

LEF1 TCF7L1 TCF7L2

1.34e-094143PF08347
Domain-

LEF1 TCF7L1 CHD3 TCF7L2

6.59e-08551441.10.30.10
DomainHMG_box_dom

LEF1 TCF7L1 CHD3 TCF7L2

1.30e-0765144IPR009071
DomainCatenin_binding_dom

LEF1 TCF7L1 TCF7L2

1.21e-0629143IPR027397
Domain-

LEF1 TCF7L1 TCF7L2

1.21e-06291434.10.900.10
DomainHMG_box

LEF1 TCF7L1 TCF7L2

7.68e-0653143PF00505
DomainHMG

LEF1 TCF7L1 TCF7L2

8.13e-0654143SM00398
DomainHMG_BOX_2

LEF1 TCF7L1 TCF7L2

8.13e-0654143PS50118
DomainRING

RBBP6 CHD3

2.13e-02305142SM00184
DomainZnf_RING

RBBP6 CHD3

2.41e-02326142IPR001841
PathwayREACTOME_RUNX3_REGULATES_WNT_SIGNALING

LEF1 TCF7L1 TCF7L2

7.06e-096113MM15542
PathwayKEGG_MEDICUS_PATHOGEN_SALMONELLA_AVRA_TO_BETA_CATENIN_SIGNALING_PATHWAY

LEF1 TCF7L1 TCF7L2

7.06e-096113M47736
PathwayKEGG_MEDICUS_PATHOGEN_KSHV_LANA_TO_WNT_SIGNALING_PATHWAY

LEF1 TCF7L1 TCF7L2

1.24e-087113M47465
PathwayKEGG_MEDICUS_VARIANT_CDH1_REDUCED_EXPRESSION_TO_BETA_CATENIN_SIGNALING_PATHWAY

LEF1 TCF7L1 TCF7L2

1.98e-088113M47413
PathwayREACTOME_REGULATION_OF_MITF_M_DEPENDENT_GENES_INVOLVED_IN_CELL_CYCLE_AND_PROLIFERATION

LEF1 TCF7L1 TCF7L2

1.98e-088113MM17229
PathwayREACTOME_RUNX3_REGULATES_WNT_SIGNALING

LEF1 TCF7L1 TCF7L2

1.98e-088113M27821
PathwayREACTOME_BINDING_OF_TCF_LEF_CTNNB1_TO_TARGET_GENE_PROMOTERS

LEF1 TCF7L1 TCF7L2

1.98e-088113M27359
PathwayKEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_AXIN_TO_WNT_SIGNALING_PATHWAY

LEF1 TCF7L1 TCF7L2

4.23e-0810113M47486
PathwayREACTOME_REPRESSION_OF_WNT_TARGET_GENES

LEF1 TCF7L1 TCF7L2

4.23e-0810113MM15156
PathwayKEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_APC_TO_WNT_SIGNALING_PATHWAY

LEF1 TCF7L1 TCF7L2

7.75e-0812113M47410
PathwayREACTOME_REPRESSION_OF_WNT_TARGET_GENES

LEF1 TCF7L1 TCF7L2

1.28e-0714113M27402
PathwayREACTOME_MITF_M_DEPENDENT_GENE_EXPRESSION

LEF1 TCF7L1 TCF7L2

1.97e-0716113MM17241
PathwayWP_AMPLIFICATION_AND_EXPANSION_OF_ONCOGENIC_PATHWAYS_AS_METASTATIC_TRAITS

LEF1 TCF7L1 TCF7L2

2.39e-0717113M39443
PathwayREACTOME_REGULATION_OF_MITF_M_DEPENDENT_GENES_INVOLVED_IN_CELL_CYCLE_AND_PROLIFERATION

LEF1 TCF7L1 TCF7L2

2.39e-0717113M48240
PathwayREACTOME_FORMATION_OF_THE_BETA_CATENIN_TCF_TRANSACTIVATING_COMPLEX

LEF1 TCF7L1 TCF7L2

9.10e-0726113MM14793
PathwayKEGG_THYROID_CANCER

LEF1 TCF7L1 TCF7L2

1.28e-0629113M523
PathwayREACTOME_DEACTIVATION_OF_THE_BETA_CATENIN_TRANSACTIVATING_COMPLEX

LEF1 TCF7L1 TCF7L2

1.73e-0632113MM14975
PathwayKEGG_MEDICUS_VARIANT_FZD7_OVEREXPRESSION_TO_WNT_SIGNALING_PATHWAY

LEF1 TCF7L1 TCF7L2

2.71e-0637113M47411
PathwayWP_INFLUENCE_OF_LAMINOPATHIES_ON_WNT_SIGNALING

LEF1 TCF7L1 TCF7L2

2.71e-0637113M39817
PathwayREACTOME_MITF_M_REGULATED_MELANOCYTE_DEVELOPMENT

LEF1 TCF7L1 TCF7L2

3.18e-0639113MM17226
PathwayREACTOME_DEACTIVATION_OF_THE_BETA_CATENIN_TRANSACTIVATING_COMPLEX

LEF1 TCF7L1 TCF7L2

3.99e-0642113M27272
PathwayKEGG_MEDICUS_VARIANT_LRP6_OVEREXPRESSION_TO_WNT_SIGNALING_PATHWAY

LEF1 TCF7L1 TCF7L2

4.93e-0645113M47412
PathwayKEGG_MEDICUS_REFERENCE_WNT_SIGNALING_PATHWAY

LEF1 TCF7L1 TCF7L2

5.27e-0646113M47409
PathwayKEGG_ENDOMETRIAL_CANCER

LEF1 TCF7L1 TCF7L2

7.65e-0652113M19877
PathwayKEGG_BASAL_CELL_CARCINOMA

LEF1 TCF7L1 TCF7L2

9.07e-0655113M17807
PathwayWP_OVERLAP_BETWEEN_SIGNAL_TRANSDUCTION_PATHWAYS_CONTRIBUTING_TO_LMNA_LAMINOPATHIES

LEF1 TCF7L1 TCF7L2

1.01e-0557113M39877
PathwayKEGG_ACUTE_MYELOID_LEUKEMIA

LEF1 TCF7L1 TCF7L2

1.01e-0557113M19888
PathwayREACTOME_CA2_PATHWAY

LEF1 TCF7L1 TCF7L2

1.30e-0562113M27321
PathwayKEGG_COLORECTAL_CANCER

LEF1 TCF7L1 TCF7L2

1.30e-0562113M14631
PathwayWP_ENDOMETRIAL_CANCER

LEF1 TCF7L1 TCF7L2

1.37e-0563113M39623
PathwayWP_ACUTE_MYELOID_LEUKEMIA

LEF1 TCF7L1 TCF7L2

1.72e-0568113M48322
PathwayWP_CHROMOSOMAL_AND_MICROSATELLITE_INSTABILITY_IN_COLORECTAL_CANCER

LEF1 TCF7L1 TCF7L2

2.13e-0573113M39758
PathwayKEGG_ADHERENS_JUNCTION

LEF1 TCF7L1 TCF7L2

2.13e-0573113M638
PathwayWP_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY

LEF1 TCF7L1 TCF7L2

2.22e-0574113M39462
PathwayKEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC

LEF1 TCF7L1 TCF7L2

2.22e-0574113M16376
PathwayREACTOME_TRANSCRIPTIONAL_REGULATION_BY_RUNX3

LEF1 TCF7L1 TCF7L2

2.41e-0576113MM15520
PathwayREACTOME_DEGRADATION_OF_BETA_CATENIN_BY_THE_DESTRUCTION_COMPLEX

LEF1 TCF7L1 TCF7L2

2.71e-0579113MM14754
PathwayPID_BETA_CATENIN_NUC_PATHWAY

LEF1 TCF7L1 TCF7L2

2.81e-0580113M223
PathwayREACTOME_DEGRADATION_OF_BETA_CATENIN_BY_THE_DESTRUCTION_COMPLEX

LEF1 TCF7L1 TCF7L2

3.37e-0585113M27079
PathwayWP_NCRNAS_INVOLVED_IN_WNT_SIGNALING_IN_HEPATOCELLULAR_CARCINOMA

LEF1 TCF7L1 TCF7L2

3.87e-0589113M39563
PathwayKEGG_PROSTATE_CANCER

LEF1 TCF7L1 TCF7L2

3.87e-0589113M13191
PathwayREACTOME_FORMATION_OF_THE_BETA_CATENIN_TCF_TRANSACTIVATING_COMPLEX

LEF1 TCF7L1 TCF7L2

4.14e-0591113M27101
PathwayREACTOME_MITF_M_DEPENDENT_GENE_EXPRESSION

LEF1 TCF7L1 TCF7L2

4.70e-0595113M48268
PathwayREACTOME_TRANSCRIPTIONAL_REGULATION_BY_RUNX3

LEF1 TCF7L1 TCF7L2

4.85e-0596113M27784
PathwayWP_LNCRNA_IN_CANONICAL_WNT_SIGNALING_AND_COLORECTAL_CANCER

LEF1 TCF7L1 TCF7L2

5.16e-0598113M39731
PathwayWP_HIPPO_SIGNALING_REGULATION

LEF1 TCF7L1 TCF7L2

5.16e-0598113M39830
PathwayKEGG_MELANOGENESIS

LEF1 TCF7L1 TCF7L2

5.65e-05101113M7761
PathwayWP_WNT_SIGNALING_AND_PLURIPOTENCY

LEF1 TCF7L1 TCF7L2

5.65e-05101113M39387
PathwayWP_MECHANISMS_ASSOCIATED_WITH_PLURIPOTENCY

LEF1 TCF7L1 ZFY IGFBP3

5.97e-05301114MM15983
PathwayWP_DNA_DAMAGE_RESPONSE_ONLY_ATM_DEPENDENT

LEF1 TCF7L1 TCF7L2

7.29e-05110113M39492
PathwayWP_WNT_SIGNALING_WP428

LEF1 TCF7L1 TCF7L2

7.90e-05113113M39669
PathwayREACTOME_GASTRULATION

LEF1 TCF7L1 TCF7L2

1.17e-04129113M46433
PathwayREACTOME_MITF_M_REGULATED_MELANOCYTE_DEVELOPMENT

LEF1 TCF7L1 TCF7L2

1.40e-04137113M48232
PathwayREACTOME_GENERIC_TRANSCRIPTION_PATHWAY

LEF1 TCF7L1 CHD3 TCF7L2 IGFBP3

1.66e-04768115MM14851
PathwayREACTOME_BETA_CATENIN_INDEPENDENT_WNT_SIGNALING

LEF1 TCF7L1 TCF7L2

1.69e-04146113M27288
PathwayKEGG_WNT_SIGNALING_PATHWAY

LEF1 TCF7L1 TCF7L2

1.87e-04151113M19428
PathwayWP_BREAST_CANCER_PATHWAY

LEF1 TCF7L1 TCF7L2

1.98e-04154113M39739
PathwayREACTOME_TCF_DEPENDENT_SIGNALING_IN_RESPONSE_TO_WNT

LEF1 TCF7L1 TCF7L2

2.13e-04158113MM14791
PathwayWP_EFFECT_OF_PROGERIN_ON_GENES_INVOLVED_IN_PROGERIA

LEF1 CHD3

3.63e-0437112M39756
PathwayREACTOME_TRANSCRIPTIONAL_REGULATION_BY_VENTX

LEF1 TCF7L2

4.46e-0441112M29748
PathwayREACTOME_CA2_PATHWAY

LEF1 TCF7L2

5.38e-0445112MM15040
PathwayPID_DELTA_NP63_PATHWAY

TCF7L1 IGFBP3

5.87e-0447112M236
PathwayREACTOME_GENE_EXPRESSION_TRANSCRIPTION

LEF1 TCF7L1 CHD3 TCF7L2 IGFBP3

6.33e-041022115MM15436
PathwayREACTOME_TCF_DEPENDENT_SIGNALING_IN_RESPONSE_TO_WNT

LEF1 TCF7L1 TCF7L2

6.67e-04233113M27099
PathwayWP_WNT_SIGNALING_WP363

LEF1 TCF7L2

6.91e-0451112M39721
PathwayREACTOME_SIGNALING_BY_WNT

LEF1 TCF7L1 TCF7L2

7.18e-04239113MM14756
PathwayKEGG_PATHWAYS_IN_CANCER

LEF1 TCF7L1 TCF7L2

1.75e-03325113M12868
PathwayREACTOME_SIGNALING_BY_WNT

LEF1 TCF7L1 TCF7L2

1.82e-03330113M7847
PathwayWNT_SIGNALING

LEF1 TCF7L1

2.09e-0389112M5493
PathwayREACTOME_RNA_POLYMERASE_II_TRANSCRIPTION

LEF1 TCF7L1 CHD3 TCF7L2 IGFBP3

2.55e-031387115M734
PathwayWP_WNT_SIGNALING_PATHWAY_AND_PLURIPOTENCY

LEF1 TCF7L1

2.68e-03101112MM15829
PathwayREACTOME_BETA_CATENIN_INDEPENDENT_WNT_SIGNALING

LEF1 TCF7L2

3.94e-03123112MM14988
PathwayWP_PLEURAL_MESOTHELIOMA

LEF1 TCF7L1 TCF7L2

4.11e-03439113M42563
PathwayWP_ENDODERM_DIFFERENTIATION

LEF1 TCF7L1

5.29e-03143112M39591
PathwayREACTOME_DEVELOPMENTAL_BIOLOGY

LEF1 TCF7L1 TCF7L2

5.98e-03502113MM14537
PathwayWP_MESODERMAL_COMMITMENT_PATHWAY

LEF1 TCF7L1

6.04e-03153112M39546
PathwayWP_CANCER_PATHWAYS

LEF1 TCF7L1 TCF7L2

6.15e-03507113M48302
PathwayREACTOME_INTRACELLULAR_SIGNALING_BY_SECOND_MESSENGERS

STRN CHD3

1.57e-02252112MM15585
PathwayREACTOME_DEVELOPMENTAL_BIOLOGY

LEF1 TCF7L1 CHD3 TCF7L2

1.95e-021432114M509
Pubmed

TCF/LEF regulation of the topologically associated domain ADI promotes mESCs to exit the pluripotent ground state.

LEF1 TCF7L1 TCF7L2

5.19e-11314334525377
Pubmed

Diverse LEF/TCF Expression in Human Colorectal Cancer Correlates with Altered Wnt-Regulated Transcriptome in a Meta-Analysis of Patient Biopsies.

LEF1 TCF7L1 TCF7L2

5.19e-11314332403323
Pubmed

A β-catenin-driven switch in TCF/LEF transcription factor binding to DNA target sites promotes commitment of mammalian nephron progenitor cells.

LEF1 TCF7L1 TCF7L2

2.08e-10414333587034
Pubmed

Mapping canonical Wnt signaling in the developing and adult retina.

LEF1 TCF7L1 TCF7L2

2.08e-10414317065530
Pubmed

Phosphorylation of TCF proteins by homeodomain-interacting protein kinase 2.

LEF1 TCF7L1 TCF7L2

5.19e-10514321285352
Pubmed

Two members of the Tcf family implicated in Wnt/beta-catenin signaling during embryogenesis in the mouse.

LEF1 TCF7L1 TCF7L2

1.04e-0961439488439
Pubmed

Postnatal isoform switch and protein localization of LEF1 and TCF7L2 transcription factors in cortical, thalamic, and mesencephalic regions of the adult mouse brain.

LEF1 TCF7L1 TCF7L2

1.04e-09614323152144
Pubmed

Dazap2 modulates transcription driven by the Wnt effector TCF-4.

LEF1 TCF7L1 TCF7L2

1.04e-09614319304756
Pubmed

β-catenin and γ-catenin are dispensable for T lymphocytes and AML leukemic stem cells.

LEF1 TCF7L1 TCF7L2

1.82e-09714332820720
Pubmed

RUNX3 attenuates beta-catenin/T cell factors in intestinal tumorigenesis.

LEF1 TCF7L1 TCF7L2

1.82e-09714318772112
Pubmed

Gene expression analysis of canonical Wnt pathway transcriptional regulators during early morphogenesis of the facial region in the mouse embryo.

LEF1 TCF7L1 TCF7L2

1.82e-09714319303461
Pubmed

Wnt3a regulates Lef-1 expression during airway submucosal gland morphogenesis.

LEF1 TCF7L1 TCF7L2

4.36e-09914317335794
Pubmed

Expression of Tcf/Lef and sFrp and localization of beta-catenin in the developing mouse lung.

LEF1 TCF7L1 TCF7L2

8.55e-091114311731265
Pubmed

Tcf7L2 is essential for neurogenesis in the developing mouse neocortex.

LEF1 TCF7L1 TCF7L2

8.55e-091114329751817
Pubmed

Redundant and additive functions of the four Lef/Tcf transcription factors in lung epithelial progenitors.

LEF1 TCF7L1 TCF7L2

1.14e-081214332414917
Pubmed

Hippocampus development and generation of dentate gyrus granule cells is regulated by LEF1.

LEF1 TCF7L1 TCF7L2

1.14e-081214310631168
Pubmed

All Tcf HMG box transcription factors interact with Groucho-related co-repressors.

LEF1 TCF7L1 TCF7L2

1.14e-081214311266540
Pubmed

Orpk mouse model of polycystic kidney disease reveals essential role of primary cilia in pancreatic tissue organization.

LEF1 TCF7L1 TCF7L2

1.88e-081414315226261
Pubmed

Dose-Dependent and Subset-Specific Regulation of Midbrain Dopaminergic Neuron Differentiation by LEF1-Mediated WNT1/b-Catenin Signaling.

LEF1 TCF7L1 TCF7L2

1.88e-081414333195246
Pubmed

Wnt3a-/--like phenotype and limb deficiency in Lef1(-/-)Tcf1(-/-) mice.

LEF1 TCF7L1 TCF7L2

1.88e-081414310090727
Pubmed

Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation.

LEF1 TCF7L1 TCF7L2

2.36e-081514315866165
Pubmed

Phases of canonical Wnt signaling during the development of mouse intestinal epithelium.

LEF1 TCF7L1 TCF7L2

2.36e-081514317681174
Pubmed

Mutant Lef1 controls Gata6 in sebaceous gland development and cancer.

LEF1 TCF7L1 TCF7L2

2.90e-081614330886049
Pubmed

Wnt/β-catenin signaling in the dental mesenchyme regulates incisor development by regulating Bmp4.

LEF1 TCF7L1 TCF7L2

5.01e-081914320883686
Pubmed

Function of Wnt/β-catenin in counteracting Tcf3 repression through the Tcf3-β-catenin interaction.

LEF1 TCF7L1 TCF7L2

5.90e-082014322573616
Pubmed

Sequential roles of Hedgehog and Wnt signaling in osteoblast development.

LEF1 TCF7L1 TCF7L2

5.90e-082014315576404
Pubmed

Tcf7l1 protects the anterior neural fold from adopting the neural crest fate.

LEF1 TCF7L1 TCF7L2

6.88e-082114327302397
Pubmed

TCF4 deficiency expands ventral diencephalon signaling and increases induction of pituitary progenitors.

LEF1 TCF7L1 TCF7L2

7.96e-082214317919533
Pubmed

Dentate gyrus morphogenesis is regulated by β-catenin function in hem-derived fimbrial glia.

LEF1 TCF7L1 TCF7L2

1.19e-072514336196585
Pubmed

The Wnt effector transcription factor 7-like 2 positively regulates oligodendrocyte differentiation in a manner independent of Wnt/β-catenin signaling.

LEF1 TCF7L1 TCF7L2

1.34e-072614325810530
Pubmed

Tcf3 and Lef1 regulate lineage differentiation of multipotent stem cells in skin.

LEF1 TCF7L1

1.50e-07214211445543
Pubmed

Restricted high level expression of Tcf-4 protein in intestinal and mammary gland epithelium.

TCF7L1 TCF7L2

1.50e-0721429916915
Pubmed

Multiple roles for activated LEF/TCF transcription complexes during hair follicle development and differentiation.

LEF1 TCF7L1

1.50e-07214210498690
Pubmed

Differential LEF1 and TCF4 expression is involved in melanoma cell phenotype switching.

LEF1 TCF7L2

1.50e-07214221599871
Pubmed

Nuclear LEF1/TCF4 correlate with poor prognosis but not with nuclear β-catenin in cerebral metastasis of lung adenocarcinomas.

LEF1 TCF7L2

1.50e-07214223224985
Pubmed

A gene family of HMG-box transcription factors with homology to TCF-1.

TCF7L1 TCF7L2

1.50e-0721421741298
Pubmed

Tbx20 acts upstream of Wnt signaling to regulate endocardial cushion formation and valve remodeling during mouse cardiogenesis.

LEF1 TCF7L1 TCF7L2

1.51e-072714323824573
Pubmed

Distinct adhesion-independent functions of β-catenin control stage-specific sensory neurogenesis and proliferation.

LEF1 TCF7L1 TCF7L2

1.51e-072714325885041
Pubmed

Integrated analysis of Wnt signalling system component gene expression.

LEF1 TCF7L1 TCF7L2

4.00e-073714335831952
Pubmed

Canonical WNT signaling promotes mammary placode development and is essential for initiation of mammary gland morphogenesis.

LEF1 TCF7L1 TCF7L2

4.00e-073714315342465
Pubmed

Tissue-specific requirements of beta-catenin in external genitalia development.

LEF1 TCF7L1 TCF7L2

4.34e-073814318635608
Pubmed

Wnt/beta-catenin signaling promotes expansion of Isl-1-positive cardiac progenitor cells through regulation of FGF signaling.

TCF7L1 TCF7L2

4.51e-07314217607356
Pubmed

A dynamic exchange of TCF3 and TCF4 transcription factors controls MYC expression in colorectal cancer cells.

TCF7L1 TCF7L2

4.51e-07314225659031
Pubmed

Plakoglobin (gamma-catenin) has TCF/LEF family-dependent transcriptional activity in beta-catenin-deficient cell line.

LEF1 TCF7L2

4.51e-07314214661054
Pubmed

In vivo transcriptional governance of hair follicle stem cells by canonical Wnt regulators.

TCF7L1 TCF7L2

4.51e-07314224463605
Pubmed

Prevalence of IGFBP3, NOS3 and TCF7L2 polymorphisms and their association with hypertension: a population-based study with Brazilian women of African descent.

TCF7L2 IGFBP3

4.51e-07314234001234
Pubmed

Identification of a promoter-specific transcriptional activation domain at the C terminus of the Wnt effector protein T-cell factor 4.

LEF1 TCF7L2

4.51e-07314212446687
Pubmed

TCF-3, 4 protein expression correlates with beta-catenin expression in MSS and MSI-H colorectal cancer from HNPCC patients but not in sporadic colorectal cancers.

TCF7L1 TCF7L2

4.51e-07314220532534
Pubmed

Histone H4 Lys 20 monomethylation by histone methylase SET8 mediates Wnt target gene activation.

LEF1 TCF7L2

4.51e-07314221282610
Pubmed

Homeodomain-mediated beta-catenin-dependent switching events dictate cell-lineage determination.

LEF1 TCF7L1 TCF7L2

8.33e-074714316678101
Pubmed

Interaction between Smad7 and beta-catenin: importance for transforming growth factor beta-induced apoptosis.

LEF1 TCF7L2

9.02e-07414215684397
Pubmed

Regulation of lymphoid enhancer factor 1/T-cell factor by mitogen-activated protein kinase-related Nemo-like kinase-dependent phosphorylation in Wnt/beta-catenin signaling.

LEF1 TCF7L2

9.02e-07414212556497
Pubmed

TCF transcription factors: molecular switches in carcinogenesis.

LEF1 TCF7L2

9.02e-07414210528152
Pubmed

Pja2 Inhibits Wnt/β-catenin Signaling by Reducing the Level of TCF/LEF1.

LEF1 TCF7L1

9.02e-07414230021253
Pubmed

Cooperative control via lymphoid enhancer factor 1/T cell factor 3 and estrogen receptor-alpha for uterine gene regulation by estrogen.

LEF1 TCF7L1

9.02e-07414218202148
Pubmed

High-resolution gene expression analysis of the developing mouse kidney defines novel cellular compartments within the nephron progenitor population.

LEF1 TCF7L1 MEIS2

1.42e-065614319591821
Pubmed

The APC tumor suppressor binds to C-terminal binding protein to divert nuclear beta-catenin from TCF.

LEF1 TCF7L2

1.50e-06514215525529
Pubmed

Dynamic expression and nuclear accumulation of beta-catenin during the development of hair follicle-derived structures.

TCF7L1 TCF7L2

2.25e-06614211731231
Pubmed

ICAT inhibits beta-catenin binding to Tcf/Lef-family transcription factors and the general coactivator p300 using independent structural modules.

LEF1 TCF7L2

2.25e-06614212408825
Pubmed

NARF, an nemo-like kinase (NLK)-associated ring finger protein regulates the ubiquitylation and degradation of T cell factor/lymphoid enhancer factor (TCF/LEF).

LEF1 TCF7L2

2.25e-06614216714285
Pubmed

Thymine DNA glycosylase promotes transactivation of β-catenin/TCFs by cooperating with CBP.

LEF1 TCF7L2

2.25e-06614224748645
Pubmed

SLUG: a new target of lymphoid enhancer factor-1 in human osteoblasts.

LEF1 TCF7L2

2.25e-06614220128911
Pubmed

Screening large numbers of expression patterns of transcription factors in late stages of the mouse thymus.

LEF1 TCF7L1 MEIS2 TCF7L2

3.01e-0626314420932939
Pubmed

Lef1 is required for the transition of Wnt signaling from mesenchymal to epithelial cells in the mouse embryonic mammary gland.

LEF1 TCF7L1

3.16e-06714216678815
Pubmed

The Wnt/beta-catenin pathway regulates Gli-mediated Myf5 expression during somitogenesis.

LEF1 TCF7L1

3.16e-06714216936075
Pubmed

TIS7 regulation of the beta-catenin/Tcf-4 target gene osteopontin (OPN) is histone deacetylase-dependent.

LEF1 TCF7L2

3.16e-06714216204248
Pubmed

Wnt signaling mediates regional specification in the vertebrate face.

LEF1 TCF7L2

4.21e-06814217699607
Pubmed

Connective tissue fibroblasts and Tcf4 regulate myogenesis.

TCF7L1 TCF7L2

4.21e-06814221177349
Pubmed

TWIST1 Homodimers and Heterodimers Orchestrate Lineage-Specific Differentiation.

TCF7L1 TCF7L2

4.21e-06814232179550
Pubmed

A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.

LEF1 TCF7L1 MEIS2 TCF7L2 ZFY

5.97e-0670914522988430
Pubmed

A critical role for the Wnt effector Tcf4 in adult intestinal homeostatic self-renewal.

TCF7L1 TCF7L2

6.76e-061014222393260
Pubmed

Tcf3 expression marks both stem and progenitor cells in multiple epithelia.

LEF1 TCF7L1

6.76e-061014225038042
Pubmed

Wnt/β-catenin signaling is disrupted in the extra-toes (Gli3(Xt/Xt) ) mutant from early stages of forebrain development, concomitant with anterior neural plate patterning defects.

LEF1 TCF7L2

8.26e-061114221452227
Pubmed

Lgr4 controls specialization of female gonads in mice.

LEF1 ZFY

9.91e-061214226333992
Pubmed

TCF/Lef1-mediated control of lipid metabolism regulates skin barrier function.

LEF1 TCF7L1

9.91e-061214221938009
Pubmed

Lrp6-mediated canonical Wnt signaling is required for lip formation and fusion.

LEF1 TCF7L2

9.91e-061214219700620
Pubmed

Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.

LEF1 TCF7L1 CHD3 MEIS2 TCF7L2

1.12e-0580814520412781
Pubmed

Tcf3 and Tcf4 are essential for long-term homeostasis of skin epithelia.

TCF7L1 TCF7L2

1.17e-051314219718027
Pubmed

Investigation of genes important in neurodevelopment disorders in adult human brain.

TCF7L1 TCF7L2

1.17e-051314226194112
Pubmed

The chromatin remodeler Mi-2beta is required for establishment of the basal epidermis and normal differentiation of its progeny.

LEF1 CHD3

1.37e-051414217360773
Pubmed

Loss of Axin2 Causes Ocular Defects During Mouse Eye Development.

LEF1 TCF7L2

1.58e-051514227701636
Pubmed

The apical ectodermal ridge is a timer for generating distal limb progenitors.

LEF1 MEIS2

1.58e-051514218359901
Pubmed

Epithelium-mesenchyme interactions control the activity of peroxisome proliferator-activated receptor beta/delta during hair follicle development.

LEF1 TCF7L1

1.58e-051514215713628
Pubmed

Pygo2 expands mammary progenitor cells by facilitating histone H3 K4 methylation.

LEF1 TCF7L2

1.80e-051614219487454
Pubmed

Hindgut defects and transformation of the gastro-intestinal tract in Tcf4(-/-)/Tcf1(-/-) embryos.

LEF1 TCF7L2

1.80e-051614215057272
Pubmed

A census of human transcription factors: function, expression and evolution.

LEF1 TCF7L1 MEIS2 TCF7L2 ZFY

1.97e-0590814519274049
Pubmed

Different roles of Runx2 during early neural crest-derived bone and tooth development.

LEF1 IGFBP3

2.04e-051714216813524
Pubmed

Notch Signaling Pathway in Tooth Shape Variations throughout Evolution.

LEF1 TCF7L1

2.29e-051814236899896
Pubmed

Restriction of Wnt signaling in the dorsal otocyst determines semicircular canal formation in the mouse embryo.

TCF7L1 TCF7L2

2.29e-051814222166339
Pubmed

Mi-2/NuRD is required in renal progenitor cells during embryonic kidney development.

LEF1 CHD3

2.29e-051814223201013
Pubmed

Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

ALMS1 TCF7L1 STRN USP40

2.33e-0544214415815621
Pubmed

Molecular functions of the TLE tetramerization domain in Wnt target gene repression.

LEF1 TCF7L1

2.56e-051914224596249
Pubmed

Pathway-based approaches to imaging genetics association studies: Wnt signaling, GSK3beta substrates and major depression.

LEF1 TCF7L2

2.56e-051914220219685
Pubmed

hnRNPH1 recruits PTBP2 and SRSF3 to modulate alternative splicing in germ cells.

TCF7L1 TCF7L2

2.56e-051914235739118
Pubmed

Fuz regulates craniofacial development through tissue specific responses to signaling factors.

LEF1 TCF7L2

2.85e-052014221935430
Pubmed

Large-scale screen for genes controlling mammalian embryogenesis, using high-throughput gene expression analysis in mouse embryos.

LEF1 TCF7L1 MEIS2

2.88e-0515214311044609
Pubmed

Wnt ligand/Frizzled 2 receptor signaling regulates tube shape and branch-point formation in the lung through control of epithelial cell shape.

LEF1 TCF7L1

3.15e-052114225114215
Pubmed

MEIS-WNT5A axis regulates development of fourth ventricle choroid plexus.

LEF1 MEIS2

3.46e-052214234032267
Pubmed

TCF7L2 regulates postmitotic differentiation programmes and excitability patterns in the thalamus.

LEF1 TCF7L2

3.46e-052214232675279
Pubmed

Tcf/Lef repressors differentially regulate Shh-Gli target gene activation thresholds to generate progenitor patterning in the developing CNS.

TCF7L1 TCF7L2

3.46e-052214221775418
CoexpressionGOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN

ALMS1 CPNE2 RBBP6 TCF7L1 STRN CHD3 TCF7L2

6.03e-071102147M2369
CoexpressionGOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN

ALMS1 CPNE2 RBBP6 TCF7L1 STRN CHD3 TCF7L2

6.89e-071124147MM1070
CoexpressionVERRECCHIA_RESPONSE_TO_TGFB1_C1

TCF7L2 IGFBP3

4.51e-0519142M16026
CoexpressionZHONG_PFC_C4_PTGDS_POS_OPC

STRN TCF7L2 KIAA0319L

6.01e-05147143M39099
CoexpressionGSE39916_B_CELL_SPLEEN_VS_PLASMA_CELL_BONE_MARROW_UP

LEF1 CHD3 USP40

1.48e-04199143M9269
CoexpressionGSE32423_MEMORY_VS_NAIVE_CD8_TCELL_IL7_IL4_DN

LEF1 TCF7L2 USP40

1.50e-04200143M5081
CoexpressionAtlasFacebaseRNAseq_e10.5_Neural Epithelium Overlying Lateral Eminence_top-relative-expression-ranked_2500_k-means-cluster#5

ALMS1 LEF1 RBBP6 MEIS2 USP40

4.34e-05654145Facebase_RNAseq_e10.5_Neural Epithelium Overlying Lateral Eminence_2500_K5
CoexpressionAtlaskidney single cell_e11.5_MetanephMesench_StemCellamp_top-relative-expression-ranked_500

ALMS1 TCF7L1 MEIS2 TCF7L2

5.63e-05339144gudmap_kidney single cell_e11.5_MetanephMesench_Scamp_500
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ Genital tubercle_emap-6706_top-relative-expression-ranked_1000

LEF1 RBBP6 MEIS2 TCF7L2 IGFBP3

9.37e-05769145gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle_1000
CoexpressionAtlasdev gonad_e11.5_F_GonadVasMes_Flk_top-relative-expression-ranked_1000

LEF1 CHD3 MEIS2 AKAP7 IGFBP3

1.35e-04831145gudmap_dev gonad_e11.5_F_GonadVasMes_Flk_1000
CoexpressionAtlasFacebaseRNAseq_e10.5_Neural Epithelium Overlying Central Eminence_top-relative-expression-ranked_2500_k-means-cluster#3

ALMS1 CPNE2 TCF7L1 CHD3 TCF7L2

1.90e-04893145Facebase_RNAseq_e10.5_Neural Epithelium Overlying Central Eminence_2500_K3
CoexpressionAtlasFacebaseRNAseq_e10.5_Neural Epithelium Overlying Lateral Eminence_top-relative-expression-ranked_1000

ALMS1 LEF1 RBBP6 MEIS2 USP40

2.97e-04983145Facebase_RNAseq_e10.5_Neural Epithelium Overlying Lateral Eminence_1000
CoexpressionAtlasFacebaseRNAseq_e10.5_Neural Epithelium Flanking Eminence_top-relative-expression-ranked_1000

ALMS1 CPNE2 LEF1 RBBP6 TCF7L2

3.05e-04989145Facebase_RNAseq_e10.5_Neural Epithelium Flanking Eminence_1000
CoexpressionAtlaskidney single cell_e11.5_MetanephMesench_StemCellamp_k-means-cluster#2_top-relative-expression-ranked_200

TCF7L1 MEIS2

3.10e-0440142gudmap_kidney single cell_e11.5_MetanephMesench_Scamp_k2_200
CoexpressionAtlasDevelopingGonad_e14.5_ ovary_emap-6699_k-means-cluster#1_top-relative-expression-ranked_1000

ALMS1 STRN USP40

3.20e-04210143gudmap_developingGonad_e14.5_ ovary_1000_k1
CoexpressionAtlasFacebaseRNAseq_e8.5_Non-Floor Plate Neural Epithelium_top-relative-expression-ranked_1000_k-means-cluster#2

CHD3 MEIS2 TCF7L2

5.21e-04248143Facebase_RNAseq_e8.5_Non-Floor Plate Neural Epithelium_1000_K2
CoexpressionAtlasFacebaseRNAseq_ratio_e10.5_MaxillaryArch_vs_Mandibular_top-relative-expression-ranked_1000_k-means-cluster#1

TCF7L1 CHD3 MEIS2

5.65e-04255143Facebase_RNAseq_ratio_e10.5_MaxillaryArch_vs_Mandibular_1000_K1
ToppCelldroplet-Tongue-TONGUE-1m-Epithelial-basal_cell_of_epidermis|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CPNE2 LEF1 CHD3 MEIS2

3.38e-07196144d4df86ce289835e76763213641989fde77935a16
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Igfbp6_Pltp|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

CPNE2 AKAP7 IGFBP3

1.02e-051391439e9f29f92dbe65b26cc78b3a1c00778c6a701f5b
ToppCellMS-CD8-proli_CD4|MS / Condition, Cell_class and T cell subcluster

CPNE2 ZFY IGFBP3

1.94e-051721430b6dd257110b3f17fa71ab18a165b091a9d5ae9a
ToppCelltumor_Lymph_Node_/_Brain-B_lymphocytes-Undetermined|B_lymphocytes / Location, Cell class and cell subclass

CPNE2 LEF1 AKAP7

2.01e-05174143390bd41ef114464f3db3e0cac4e67fe7571b4c23
ToppCellCOVID-19-kidney-AQP1+SLC14A1+EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

TCF7L1 MEIS2 IGFBP3

2.18e-051791431ce8d18f63e8dd2d3db41fbeca4601bd3b305fba
ToppCellkidney_cells-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CPNE2 LEF1 MEIS2

2.53e-05188143a37edd8f9e4a4e336b5acbb0407d3d275975cee8
ToppCellE12.5-Mesenchymal|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

LEF1 CHD3 MEIS2

2.53e-051881439778dadc2bd7ded3a723e717d1c8cd3160e99c6c
ToppCelldroplet-Thymus-nan-18m-Lymphocytic-double_negative_T_cell|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LEF1 CHD3 TCF7L2

2.61e-0519014384265be128170cbb08d76e824aa108e07da9c3e5
ToppCellCOVID-19-kidney-AQP1+SLC14A1+EC|kidney / Disease (COVID-19 only), tissue and cell type

TCF7L1 MEIS2 IGFBP3

2.61e-051901431519f34d31fe0817184c5865a0bc9f0cb479b1a4
ToppCellfacs-Liver-Liver_non-hepato/SCs_st-18m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CPNE2 TCF7L1 MEIS2

2.65e-0519114388f91e57a1409bdeb91e9bf47510a6fb998a1bf5
ToppCellfacs-Liver-Liver_non-hepato/SCs_st-18m-Endothelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CPNE2 TCF7L1 MEIS2

2.65e-051911431924af7d8b0a0b892e480a9fd6d874941b0c0b5d
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TCF7L1 MEIS2 IGFBP3

2.73e-051931432e72309607902dabe3218888b22a77fe941f3570
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CPNE2 TCF7L1 MEIS2

2.82e-0519514323ced69fd904f1d4114b1a7f99f4b5f65ea8824b
ToppCellE12.5-Mesenchymal-mesenchymal_fibroblast-mesenchymal_alveolar_niche_cell|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

CHD3 MEIS2 IGFBP3

2.82e-05195143febe746099964b9ea9e75f2efc72c962c01f0421
ToppCellfacs-Liver-Liver_non-hepato/SCs-18m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CPNE2 TCF7L1 MEIS2

2.86e-0519614381900dcc9451ff6606ec940c16b559d73247590e
ToppCellfacs-Liver-Liver_non-hepato/SCs-18m-Endothelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CPNE2 TCF7L1 MEIS2

2.90e-05197143d584d0334ea97e3fa8c4cd869f5eeea2c7a1ed04
ToppCellfacs-Liver-Liver_non-hepato/SCs-18m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CPNE2 TCF7L1 MEIS2

2.90e-05197143412091994196a06c2779b4c2cfed84be889a5f8d
ToppCellParenchymal-10x5prime-Endothelial-Endothelia_vascular-VE_systemic_arterial|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

CPNE2 MEIS2 IGFBP3

2.90e-05197143ad4a3b5da2190be9495382a2952991e1de9f190d
ToppCelldistal-Endothelial-Artery-1|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

CPNE2 MEIS2 IGFBP3

2.95e-05198143f284f59f4ebe55ee132eddfaa2f5d9ecb059654f
ToppCelldistal-3-Endothelial-Artery|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

CPNE2 MEIS2 IGFBP3

2.99e-051991437814804f4ecc0655610e5c85f513b3976d856192
ToppCelldistal-1-Endothelial-Artery|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

CPNE2 MEIS2 IGFBP3

2.99e-05199143fd71d08f6de790a29c880d50d2ed0881952d7791
ToppCelldistal-Endothelial-Artery-3|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

CPNE2 MEIS2 IGFBP3

2.99e-051991438acf381087268fcf13f025e3b67e028bf1f9b77e
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-2M-Radial_glial-RGCs_3|Organoid-2M / Sample Type, Dataset, Time_group, and Cell type.

LEF1 TCF7L1 MEIS2

3.04e-0520014355a1df656545ff078b727d55e4d65d61ddb5c41f
ToppCellControl-Control-Lymphocyte-T/NK-dn_T|Control / Disease, condition lineage and cell class

CPNE2 LEF1 CHD3

3.04e-0520014310882c59b7aaf8bd4b5c00aa4ddbb9f7ac5b2cf5
ToppCellThalamus|World / BrainAtlas - Mouse McCarroll V32

LEF1 TCF7L2

5.88e-041161425ddfb2dd5459ff6d7ae38163a38eae64fda283b7
ToppCelldroplet-Liver-nan-3m-Myeloid-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ALMS1 KIAA0319L

7.04e-0412714239fa20a55de3af1a62ab5dfa4877879db3935ac2
ToppCellE18.5-samps-Mesenchymal-Myofibroblast-myofibroblast_-_mature_-_B|E18.5-samps / Age Group, Lineage, Cell class and subclass

ALMS1 IGFBP3

8.18e-04137142b553958e7e6dcd887d860e34d3983cbb85cefaa6
ToppCell(08)_Brush+PNEC-(2)_GFP_FOXI1|(08)_Brush+PNEC / shred by cell type by condition

RBBP6 IGFBP3

8.30e-04138142817e3f639604ea95adae01e8685ffaa2e0aff7a8
ToppCellPND07-28-samps-Mesenchymal-Myofibroblast-MyoFB-3|PND07-28-samps / Age Group, Lineage, Cell class and subclass

TCF7L1 IGFBP3

8.66e-041411427ae8ead02e5aeb4106c4a30c08a7a061da3a5d6a
ToppCellCOVID-19-kidney-Mito-rich_EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

TCF7L1 MEIS2

9.15e-04145142afed661aef990edb8e7012ab67ace56443520c9f
ToppCellMS-CD8-CD8_2|MS / Condition, Cell_class and T cell subcluster

CPNE2 LEF1

9.79e-0415014201c20d787ce269db0d153e63a600a8d9ead61856
ToppCelldroplet-Lung-nan-3m-Myeloid-dendritic_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CPNE2 STRN

1.00e-0315214277b319f594d5e4df29034bbf69c7490076f89dd3
ToppCellLeuk-UTI-Lymphocyte-T_NK-Treg|Leuk-UTI / Disease, Lineage and Cell Type

CPNE2 LEF1

1.02e-03153142b24c693b142206d13b29c96faa7f79a1a22bc2ef
ToppCellSmart-seq2-tissue-resident_(Smart-seq2)-lymphocytic-T_lymphocytic-CD8-positive,_alpha-beta_memory_T_cell|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

LEF1 ZFY

1.02e-0315314264d0f37d7af9b76234f683379e3689771f71fe70
ToppCellPND28-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-CD4_T-CD4_T_prolif|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LEF1 CHD3

1.02e-031531425ac4b97d35c1029a5fc625239f92e35136c4d832
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell_prolif|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

LEF1 MEIS2

1.03e-03154142e51a5114f0ec38f997f5b8bbf3a7770f98595474
ToppCellURO-Lymphocyte-T_NK-Treg|URO / Disease, Lineage and Cell Type

LEF1 IGFBP3

1.03e-0315414273fe0e26088a1b012902cc062ffbb3e4d2ff09f9
ToppCell343B-Lymphocytic-NK_cells-NK_cell_B0|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

CPNE2 IGFBP3

1.04e-03155142583cfaa41c755c63aee312eb442e9d97f645d5f7
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_artery-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

MEIS2 IGFBP3

1.07e-03157142275a4c6fef1fff8da2bdc48e3924ad05c5e5cfc8
ToppCellControl-Lymphocyte-T_NK-dnT|Control / Disease, Lineage and Cell Type

CPNE2 LEF1

1.08e-031581427a2fad6426549d910834debfe5e102fe2ab5976d
ToppCelldroplet-Spleen-nan-24m-Myeloid|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CPNE2 TCF7L2

1.08e-0315814272e4f8ae137a7dddee0dc6236532e0711065e6af
ToppCelldroplet-Spleen-nan-24m-Myeloid-nan|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CPNE2 TCF7L2

1.08e-03158142e1a8dba5a88bc3ce112829c5ecb112cbbee5b078
ToppCellBac-SEP-Lymphocyte-T_NK-MAIT|Bac-SEP / Disease, Lineage and Cell Type

CPNE2 IGFBP3

1.10e-03159142e043c65f3febdfa7f75a67702e92fcdebe144a00
ToppCell3'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.1.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TCF7L1 IGFBP3

1.10e-0315914222427ad4ad2e797e4664e7a7b0514094f22a18b2
ToppCellMultiple_Sclerosis-Lymphocyte-T_NK-Treg|Multiple_Sclerosis / Disease, Lineage and Cell Type

CPNE2 LEF1

1.14e-03162142975d52e3cc101e7592425128e1099d30847a8a42
ToppCellfacs-Lung-ENDOMUCIN-18m-Lymphocytic-CD4-positive,_alpha-beta_T_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ALMS1 CHD3

1.15e-031631424af92b211d12c5b88b65bb746242cd702b545bd0
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c02-AQP3|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

LEF1 IGFBP3

1.15e-031631429195051d6bcdd450ed745a099828a0d76d9d3f0b
ToppCellfacs-Lung-ENDOMUCIN-18m-Lymphocytic-CD4+_T|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ALMS1 CHD3

1.15e-03163142d24774e0aa612322c22fdb3b314aef275fa01d68
ToppCellfacs-Kidney-nan-3m-Lymphocytic-T_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ALMS1 LEF1

1.15e-031631428004cc0b3428be08b89957b563cd8799f822d931
ToppCellfacs-Kidney-nan-3m-Lymphocytic-T_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ALMS1 LEF1

1.15e-03163142385b24e18df5ef92108483de312d6c85a1e6d145
ToppCellPND10-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CPNE2 MEIS2

1.17e-031641425e5bd81414ea2d64f73cdef19a0a78c17bec8c18
ToppCellPND10-Endothelial-Endothelial_lymphatic|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CPNE2 MEIS2

1.17e-03164142f13b8d9b7f42193f333d9a77571a1dde6bbb48d8
ToppCellPND10-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CPNE2 MEIS2

1.17e-031641424cfc9f92e49f86d3639e018b35b6a60dc62f494a
ToppCellPND10-Endothelial-Endothelial_lymphatic-Lymphatic_EC|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CPNE2 MEIS2

1.17e-031641427a8e5ef52a8fd2877d59ef0696af8a7af90bbed6
ToppCellmetastatic_Lymph_Node-T/NK_cells-Naive_CD8+_T|T/NK_cells / Location, Cell class and cell subclass

CPNE2 IGFBP3

1.18e-0316514234f0394356b96e31b87fb8c2fd323cf7a3f077e3
ToppCellPND03-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CPNE2 MEIS2

1.18e-03165142347b59aa625a8a960828b8620824d8ac48990e07
ToppCellPND03-Endothelial-Endothelial_lymphatic|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CPNE2 MEIS2

1.18e-031651421890f9c33b0c5b381d57f97042da2610a093a6de
ToppCelldroplet-Lung-3m-Hematologic-myeloid-myeloid_dendritic_cell-Ccr7+_dendritic|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CPNE2 STRN

1.18e-03165142c39f0479955c4e23921f7a450d3bc251a002200f
ToppCell390C-Lymphocytic-NK_cells-NK_cell_B0|NK_cells / Donor, Lineage, Cell class and subclass (all cells)

MEIS2 IGFBP3

1.18e-03165142ebd668e87e5961a124d1d6fc25d1f03e4af05cd4
ToppCelldroplet-Liver-LIVER-NPC-1m-Lymphocytic-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AKAP7 IGFBP3

1.18e-031651428c7a6f9e2ca0ce077426d3d0726e3f5a4c03b296
ToppCellPND03-Endothelial-Endothelial_lymphatic-Lymphatic_EC|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CPNE2 MEIS2

1.18e-03165142507c89ece0a336b8e9c65b79889a714e17ddca27
ToppCellPND03-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CPNE2 MEIS2

1.18e-0316514239a25be081a5d59c7cf107a997d352793d5025fb
ToppCellControl-Epithelial-Mesothelial|Control / Disease state, Lineage and Cell class

MEIS2 IGFBP3

1.20e-031661421ed3788257e14f097862b999f020bfe2a57de52b
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

LEF1 MEIS2

1.20e-031661428e5f2afbeffae5e77fcb29e8fe9f5aa49779b619
ToppCell3'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CHD3 MEIS2

1.20e-031661429fd9de82f98b9acdaa59ac98fb9664161514aec0
ToppCellfacs-Thymus-Thymus_Flowthrough-18m-Lymphocytic-DN4_thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LEF1 CHD3

1.21e-03167142d72b08b3cbc34b30a11dcf512e472b64d1606ec1
ToppCellCOVID-19_Moderate-Treg|COVID-19_Moderate / disease group, cell group and cell class

CPNE2 LEF1

1.21e-031671424ddb21421cbe72c06b61dd3a5eb1337e59de42e5
ToppCellfacs-Thymus-Thymus_Flowthrough-18m-Lymphocytic-DN4_thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LEF1 CHD3

1.21e-0316714222f7384ff2044898d7b0b01cb9d9a3cbaa93a9a3
ToppCellfacs-Skin-Anagen-24m-Epithelial-bulge_keratinocyte|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TCF7L1 TCF7L2

1.21e-0316714278909f685ccd1321064eb0887caf9263e0e54879
ToppCellfacs-Lung-18m-Hematologic-lymphocytic-CD8-positive,_alpha-beta_T_cell-CD8-positive,_alpha-beta_T_cell_l21|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

LEF1 CHD3

1.22e-031681426c758eb120faf06ff72d157b495e399191c79ec9
ToppCellAdult-Endothelial-endothelial_cell_of_artery-D231|Adult / Lineage, Cell type, age group and donor

MEIS2 IGFBP3

1.22e-03168142aca34c51758c65925ad24110294a72b2dea6db72
ToppCellsystemic_lupus_erythematosus-flare-Lymphocytic_T-CD4-positive,_alpha-beta_T_cell-male|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

LEF1 ZFY

1.22e-031681425e721268f0baa51d3f640f7f4c41db769ebef210
ToppCellkidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell__prolif|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CPNE2 MEIS2

1.22e-0316814237249f38f8f04ec5743097259de67b106ca2b02f
ToppCelldroplet-Lung-LUNG-30m-Myeloid-dendritic_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ALMS1 CPNE2

1.22e-031681420e8b0e6399c6c82c9c0e546f7316f902de0765d3
ToppCellfacs-Limb_Muscle-forelimb_and_hindlimb-18m-Lymphocytic-T_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

STRN CHD3

1.22e-03168142182f08106ac65ea501e2fb9139d3b44b7c4662c9
ToppCell356C-Endothelial_cells-Endothelial-B_(Artery)|356C / Donor, Lineage, Cell class and subclass (all cells)

MEIS2 IGFBP3

1.24e-03169142605cc2638271803cf1d972ab3fa8f13f89666376
ToppCelldroplet-Lung-nan-3m-Lymphocytic-CD4+_T|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LEF1 CHD3

1.24e-03169142b7db33be24a6a9386e277c2f8949551e4d259305
ToppCell356C-Endothelial_cells-Endothelial-B_(Artery)-|356C / Donor, Lineage, Cell class and subclass (all cells)

MEIS2 IGFBP3

1.24e-03169142337be3bf485b54afad86e256cb0c4c1d0c2a9a2a
ToppCelldroplet-Lung-nan-3m-Lymphocytic-CD4-positive,_alpha-beta_T_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LEF1 CHD3

1.24e-0316914281bbdcf1fdf5cad5bfe7a559af196ad0d8e18c35
ToppCell5'-Adult-SmallIntestine-Hematopoietic-T_cells-SELL+_CD8_T|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CPNE2 LEF1

1.24e-03169142cc1b60eb50a274ffd72c67082c19e43af775e949
ToppCell343B-Lymphocytic-NK_cells-NK_cell_B0|NK_cells / Donor, Lineage, Cell class and subclass (all cells)

CPNE2 IGFBP3

1.24e-0316914289b5452e0d8d058648a1d2659f1611fd6aebc6b6
ToppCelldroplet-Thymus-nan-18m-Lymphocytic-DN4_thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LEF1 CHD3

1.25e-0317014290f7640f04672c800cb28aea50004b1bb0565e8a
ToppCellControl-Epithelial_cells-ECM-high_epithelial|Control / group, cell type (main and fine annotations)

ZFY AKAP7

1.25e-03170142e2023d66e70983c87dacbd6181d3426488d1fc57
ToppCellfacs-Lung-18m-Hematologic-lymphocytic-CD4-positive,_alpha-beta_T_cell-CD4-positive,_alpha-beta_T_cell_l21|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ALMS1 LEF1

1.25e-03170142bda900c836e0f2c1d7b442beb50b672d025b2420
ToppCellPND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_prolif|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TCF7L1 IGFBP3

1.25e-031701428465c3069bbc08705d070927e712b6bc85ac7c5b
ToppCellPND14-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CPNE2 MEIS2

1.27e-03171142686f95892c3909973c66c9a27159a070a068f175
ToppCelldroplet-Thymus-nan-18m-Lymphocytic-DN4|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LEF1 CHD3

1.27e-03171142f08402d0f42822c35673522043b652f8fb68d2f6
ToppCellPND14-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CPNE2 MEIS2

1.27e-03171142f7ba03e7bdb687f93782c936c7b3374cc5b3b77c
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_artery-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

MEIS2 IGFBP3

1.27e-031711421597459c971d6befa991d59dc66b41b6a522f797
ToppCelldroplet-Lung-30m-Hematologic-lymphocytic-CD4-positive,_alpha-beta_T_cell-CD4-positive,_alpha-beta_T_cell_l21|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

LEF1 CHD3

1.27e-03171142a8adce007ff4c713f71f2359b40cb3575b28c98d
ToppCellPND14-Endothelial-Endothelial_lymphatic-Lymphatic_EC|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CPNE2 MEIS2

1.27e-03171142fbf8e9db00573adcada4b25730e191417b7c9999
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

MEIS2 IGFBP3

1.27e-031711422a77ed79c6f2e700e789c80451a70ecb31639719
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

MEIS2 IGFBP3

1.27e-03171142972fab891135bd755d5526cbc5a963200067b0a6
ToppCellPND14-Endothelial-Endothelial_lymphatic|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CPNE2 MEIS2

1.27e-03171142d0ac50071a3854d02113c455fcc940a6ec59bbb9
ToppCellImmune_cells-pro-B|Immune_cells / Lineage and Cell class

LEF1 TCF7L2

1.28e-03172142096636f2589fa56d15942aac96641c16fd5fa78d
ToppCellfacs-Lung-Endomucin-3m-Endothelial-Lymphatic_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CPNE2 TCF7L1

1.28e-03172142b3c4adccc34bb9e4e78e40f4e2e23736c347cc75
ToppCellPND28-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-CD4_T-CD4_T_mature|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LEF1 CHD3

1.28e-0317214225bf2551d698237bfd912c2ff067b1600dfb19ca
ToppCellfacs-Lung-Endomucin-3m-Endothelial-endothelial_cell_of_lymphatic_vessel|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CPNE2 TCF7L1

1.28e-031721422f1673fcb2356684d60871debb0f159aec553a1c
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-6_VIP_RGS16|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CPNE2 IGFBP3

1.28e-031721428b396d1e9173da104d467e42286379fe07cee257
ToppCelldroplet-Lung-LUNG-30m-Lymphocytic-CD4-positive,_alpha-beta_T_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LEF1 CHD3

1.28e-03172142f320813177f246926bfd5862b4e0f9bd828cebab
Drugstacker

LEF1 TCF7L1 TCF7L2

4.77e-0726143CID000092326
DrugCKI-7

LEF1 TCF7L1 TCF7L2

4.26e-0653143CID000129236
DrugEburnamonine (-) [4880-88-0]; Down 200; 13.6uM; PC3; HT_HG-U133A

STRN CHD3 TCF7L2 AKAP7

4.41e-061901447154_DN
DrugIsoxicam [34552-84-6]; Up 200; 12uM; PC3; HT_HG-U133A

RBBP6 STRN TCF7L2 AKAP7

4.98e-061961441820_UP
DrugKynurenine, 3-hydroxy (R,S) [2147-61-7]; Up 200; 17.8uM; MCF7; HT_HG-U133A

CHD3 TCF7L2 KIAA0319L IGFBP3

5.08e-061971445276_UP
Drugflurbiprofen

LEF1 TCF7L1 TCF7L2

1.43e-04171143CID000003394
DrugHexetidine [141-94-6]; Up 200; 11.8uM; MCF7; HT_HG-U133A

AKAP7 KIAA0319L IGFBP3

1.43e-041711433318_UP
DrugCycloheximide [66-81-9]; Up 200; 14.2uM; MCF7; HT_HG-U133A

MEIS2 TCF7L2 IGFBP3

1.48e-041731433464_UP
Drug1-alpha-25-dihydroxycholecalciferol

ALMS1 TCF7L1 STRN IGFBP3 USP40

1.49e-04909145CID000002524
DrugAzaguanine-8 [134-58-7]; Down 200; 26.2uM; PC3; HT_HG-U133A

ALMS1 RBBP6 TCF7L2

1.69e-041811431791_DN
Drug17-AAG; Up 200; 1uM; MCF7; HT_HG-U133A

STRN CHD3 IGFBP3

1.74e-041831436985_UP
Drugnickel subsulfide

LEF1 TCF7L1 IGFBP3

1.89e-04188143ctd:C017557
DrugC768-0445; Up 200; 10uM; MCF7; HT_HG-U133A_EA

ALMS1 CHD3 MEIS2

1.92e-04189143973_UP
DrugDietary Carbohydrates

LEF1 STRN TCF7L2

1.92e-04189143ctd:D004040
DrugApigenin [520-36-5]; Down 200; 14.8uM; MCF7; HT_HG-U133A

ALMS1 TCF7L2 IGFBP3

1.92e-041891434401_DN
DrugClonidine hydrochloride [4205-91-8]; Down 200; 15uM; MCF7; HT_HG-U133A

STRN MEIS2 TCF7L2

1.95e-041901433172_DN
DrugSanguinarine [2447-54-3]; Down 200; 12uM; MCF7; HT_HG-U133A

ALMS1 STRN CHD3

1.98e-041911434168_DN
DrugRapamycin; Down 200; 0.1uM; MCF7; HT_HG-U133A

ALMS1 TCF7L2 KIAA0319L

1.98e-041911435567_DN
DrugButacaine [149-16-6]; Down 200; 13uM; MCF7; HT_HG-U133A

TCF7L2 KIAA0319L IGFBP3

2.01e-041921433469_DN
DrugPiperine [94-62-2]; Down 200; 14uM; MCF7; HT_HG-U133A

ALMS1 TCF7L2 AKAP7

2.04e-041931433263_DN
DrugEthynodiol diacetate [297-76-7]; Down 200; 10.4uM; MCF7; HT_HG-U133A

CHD3 TCF7L2 IGFBP3

2.04e-041931435024_DN
DrugCimetidine [51481-61-9]; Down 200; 15.8uM; MCF7; HT_HG-U133A

ALMS1 STRN CHD3

2.04e-041931431464_DN
Druggeldanamycin; Down 200; 1uM; MCF7; HT_HG-U133A

ALMS1 TCF7L2 KIAA0319L

2.04e-041931435588_DN
DrugPrazosin hydrochloride [19237-84-4]; Down 200; 9.6uM; HL60; HT_HG-U133A

CHD3 AKAP7 KIAA0319L

2.04e-041931433098_DN
DrugNorcyclobenzaprine [303-50-4]; Down 200; 15.4uM; HL60; HT_HG-U133A

ALMS1 TCF7L2 KIAA0319L

2.07e-041941432469_DN
DrugSulconazole nitrate [61318-91-0]; Down 200; 8.6uM; HL60; HT_HG-U133A

RBBP6 TCF7L2 AKAP7

2.07e-041941433035_DN
DrugGallamine triethiodide [65-29-2]; Down 200; 4.4uM; MCF7; HT_HG-U133A

AKAP7 KIAA0319L IGFBP3

2.07e-041941432221_DN
DrugIsocarboxazid [59-63-2]; Down 200; 17.2uM; MCF7; HT_HG-U133A

CHD3 KIAA0319L IGFBP3

2.10e-041951434706_DN
DrugMetolazone [17560-51-9]; Down 200; 11uM; PC3; HG-U133A

RBBP6 CHD3 TCF7L2

2.10e-041951431932_DN
DrugTrimethoprim [738-70-5]; Up 200; 13.8uM; PC3; HT_HG-U133A

CHD3 TCF7L2 KIAA0319L

2.10e-041951437377_UP
DrugPipenzolate bromide [125-51-9]; Down 200; 9.2uM; HL60; HT_HG-U133A

STRN TCF7L2 AKAP7

2.10e-041951432719_DN
Drug17-AAG; Down 200; 1uM; SKMEL5; HG-U133A

RBBP6 AKAP7 KIAA0319L

2.10e-04195143505_DN
Drug15d-PGJ2; Down 200; 10uM; MCF7; HT_HG-U133A

TCF7L2 KIAA0319L IGFBP3

2.10e-041951435591_DN
DrugGlibenclamide [10238-21-8]; Down 200; 8uM; MCF7; HT_HG-U133A

ALMS1 TCF7L2 AKAP7

2.10e-041951433163_DN
DrugMetixene hydrochloride [1553-34-0]; Down 200; 11.6uM; MCF7; HT_HG-U133A

ALMS1 AKAP7 KIAA0319L

2.13e-041961435018_DN
DrugAllantoin [97-59-6]; Up 200; 25.2uM; PC3; HT_HG-U133A

ALMS1 CHD3 KIAA0319L

2.13e-041961435052_UP
DrugPiretanide [55837-27-9]; Down 200; 11uM; MCF7; HT_HG-U133A

STRN AKAP7 KIAA0319L

2.13e-041961433567_DN
DrugPenbutolol sulfate [38363-32-5]; Down 200; 5.8uM; MCF7; HT_HG-U133A

ALMS1 AKAP7 KIAA0319L

2.13e-041961433534_DN
DrugPaclitaxel [33069-62-4]; Down 200; 4.6uM; PC3; HG-U133A

ALMS1 RBBP6 TCF7L2

2.13e-041961431959_DN
DrugFluvastatin sodium salt [93957-55-2]; Down 200; 9.2uM; MCF7; HT_HG-U133A

CHD3 MEIS2 TCF7L2

2.13e-041961435290_DN
DrugNeomycin sulfate [1405-10-3]; Down 200; 4.2uM; MCF7; HT_HG-U133A

AKAP7 KIAA0319L IGFBP3

2.13e-041961432229_DN
DrugTranexamic acid [1197-18-8]; Down 200; 25.4uM; MCF7; HT_HG-U133A

AKAP7 KIAA0319L IGFBP3

2.13e-041961432248_DN
Drug5162773; Down 200; 7uM; MCF7; HT_HG-U133A_EA

ALMS1 CHD3 KIAA0319L

2.13e-04196143892_DN
DrugDobutamine hydrochloride [49745-95-1]; Down 200; 11.8uM; MCF7; HT_HG-U133A

STRN KIAA0319L IGFBP3

2.13e-041961435386_DN
DrugPancuronium bromide [15500-66-0]; Down 200; 5.4uM; MCF7; HT_HG-U133A

ALMS1 AKAP7 IGFBP3

2.13e-041961437329_DN
DrugICI 182,780; Down 200; 1uM; HL60; HT_HG-U133A

ALMS1 CHD3 TCF7L2

2.13e-041961431146_DN
DrugFenspiride hydrochloride [5053-08-7]; Down 200; 13.4uM; PC3; HT_HG-U133A

TCF7L2 AKAP7 KIAA0319L

2.13e-041961437298_DN
DrugStreptomycin sulfate [3810-74-0]; Down 200; 2.8uM; MCF7; HT_HG-U133A

STRN TCF7L2 KIAA0319L

2.16e-041971437194_DN
DrugTriflupromazine hydrochloride [1098-60-8]; Up 200; 10.2uM; MCF7; HT_HG-U133A

TCF7L2 AKAP7 KIAA0319L

2.16e-041971431691_UP
DrugPaclitaxel [33069-62-4]; Down 200; 4.6uM; MCF7; HT_HG-U133A

ALMS1 STRN MEIS2

2.16e-041971435320_DN
DrugAtracurium besylate [64228-81-5]; Up 200; 3.2uM; PC3; HT_HG-U133A

RBBP6 TCF7L2 KIAA0319L

2.16e-041971431824_UP
DrugEquilin [474-86-2]; Down 200; 15uM; HL60; HT_HG-U133A

LEF1 TCF7L2 AKAP7

2.16e-041971433039_DN
DrugAztreonam [78110-38-0]; Down 200; 9.2uM; MCF7; HT_HG-U133A

STRN AKAP7 KIAA0319L

2.16e-041971432282_DN
DrugTelenzepine dihydrochloride [147416-96-4]; Up 200; 9uM; MCF7; HT_HG-U133A

STRN TCF7L2 AKAP7

2.16e-041971437419_UP
DrugTheobromine [83-67-0]; Up 200; 22.2uM; MCF7; HT_HG-U133A

TCF7L1 STRN IGFBP3

2.16e-041971433334_UP
DrugSulfacetamide sodic hydrate [6209-17-2]; Up 200; 15.8uM; MCF7; HT_HG-U133A

STRN TCF7L2 IGFBP3

2.16e-041971431695_UP
DrugEnoxacin [74011-58-8]; Down 200; 12.4uM; MCF7; HT_HG-U133A

TCF7L2 AKAP7 KIAA0319L

2.16e-041971435616_DN
DrugEserine sulfate, physostigmine sulfate [64-47-1]; Down 200; 6.2uM; MCF7; HT_HG-U133A

ALMS1 STRN TCF7L2

2.16e-041971436226_DN
Drugalpha-estradiol; Down 200; 0.01uM; HL60; HT_HG-U133A

STRN TCF7L2 KIAA0319L

2.16e-041971436169_DN
DrugPNU-0230031 [267429-39-0]; Up 200; 1uM; MCF7; HT_HG-U133A

TCF7L1 KIAA0319L IGFBP3

2.16e-041971433632_UP
DrugPicotamide monohydrate [80530-63-8]; Down 200; 10.2uM; MCF7; HT_HG-U133A

ALMS1 TCF7L2 KIAA0319L

2.16e-041971436787_DN
DrugSeneciphylline [480-81-9]; Up 200; 12uM; HL60; HT_HG-U133A

ALMS1 TCF7L2 KIAA0319L

2.16e-041971432140_UP
DrugMerbromin [129-16-8]; Down 200; 5uM; MCF7; HT_HG-U133A

STRN TCF7L2 IGFBP3

2.16e-041971433439_DN
DrugPseudopelletierine hydrochloride [6164-62-1]; Up 200; 21uM; MCF7; HT_HG-U133A

ALMS1 CHD3 KIAA0319L

2.16e-041971432766_UP
DrugTropicamide [1508-75-4]; Down 200; 14uM; MCF7; HT_HG-U133A

ALMS1 TCF7L2 KIAA0319L

2.16e-041971432309_DN
DrugCatechin-(+,-) hydrate [7295-85-4]; Down 200; 13.8uM; MCF7; HT_HG-U133A

MEIS2 TCF7L2 AKAP7

2.20e-041981434837_DN
DrugMethyldopa (L,-) [555-30-6]; Up 200; 19uM; MCF7; HT_HG-U133A

TCF7L1 TCF7L2 IGFBP3

2.20e-041981435272_UP
DrugAC1L9NAZ

LEF1 TCF7L1 TCF7L2

2.20e-04198143CID000449606
DrugHydrocotarnine hydrobromide [5985-00-2]; Down 200; 13.2uM; MCF7; HT_HG-U133A

CHD3 TCF7L2 AKAP7

2.20e-041981436827_DN
DrugCapsaicin [404-86-4]; Down 200; 13uM; MCF7; HT_HG-U133A

CHD3 TCF7L2 AKAP7

2.20e-041981435673_DN
DrugQuinic acid [86-68-0]; Down 200; 19.6uM; MCF7; HT_HG-U133A

TCF7L2 AKAP7 KIAA0319L

2.20e-041981436019_DN
DrugHarmane hydrochloride [21655-84-5]; Up 200; 18.2uM; MCF7; HT_HG-U133A

AKAP7 KIAA0319L IGFBP3

2.20e-041981432806_UP
DrugSulfasalazine [599-79-1]; Up 200; 10uM; HL60; HG-U133A

ALMS1 CHD3 TCF7L2

2.20e-041981431733_UP
DrugParomomycin sulfate [1263-89-4]; Up 200; 5.6uM; MCF7; HT_HG-U133A

CHD3 KIAA0319L IGFBP3

2.20e-041981433356_UP
DrugDexamethasone acetate [1177-87-3]; Down 200; 9.2uM; MCF7; HT_HG-U133A

AKAP7 KIAA0319L IGFBP3

2.20e-041981432242_DN
DrugBetazole hydrochloride; Down 200; 27uM; MCF7; HT_HG-U133A

CHD3 TCF7L2 AKAP7

2.20e-041981431690_DN
Drug5286656; Down 200; 50uM; MCF7; HT_HG-U133A_EA

CHD3 TCF7L2 KIAA0319L

2.20e-04198143889_DN
DrugAcemetacin [53164-05-9]; Down 200; 9.6uM; MCF7; HT_HG-U133A

ALMS1 CHD3 TCF7L2

2.20e-041981437442_DN
DrugLisuride (S)(-) [18016-80-3]; Down 200; 11.8uM; MCF7; HT_HG-U133A

ALMS1 TCF7L2 KIAA0319L

2.20e-041981435028_DN
DrugSalsolinol hydrobromide [38221-21-5]; Up 200; 15.4uM; MCF7; HT_HG-U133A

STRN AKAP7 KIAA0319L

2.20e-041981432791_UP
DrugKarakoline [39089-30-0]; Up 200; 10.6uM; MCF7; HT_HG-U133A

LEF1 KIAA0319L IGFBP3

2.20e-041981433638_UP
DrugFelbinac [5728-52-9]; Down 200; 18.8uM; MCF7; HT_HG-U133A

ALMS1 STRN AKAP7

2.20e-041981433398_DN
DrugMegestrol acetate [595-33-5]; Down 200; 10.4uM; MCF7; HT_HG-U133A

CHD3 TCF7L2 AKAP7

2.20e-041981435013_DN
DrugPropranolol hydrochloride [318-98-9]; Down 200; 13.6uM; HL60; HT_HG-U133A

LEF1 TCF7L2 KIAA0319L

2.23e-041991433059_DN
DrugMetronidazole [443-48-1]; Up 200; 23.4uM; PC3; HT_HG-U133A

LEF1 STRN AKAP7

2.23e-041991434023_UP
DrugHydrocotarnine hydrobromide [5985-00-2]; Up 200; 13.2uM; MCF7; HT_HG-U133A

TCF7L2 AKAP7 KIAA0319L

2.23e-041991432765_UP
DrugNomifensine maleate [32795-47-4]; Down 200; 11.2uM; MCF7; HT_HG-U133A

ALMS1 CHD3 TCF7L2

2.23e-041991437217_DN
DrugCyproheptadine hydrochloride [969-33-5]; Down 200; 12.4uM; PC3; HT_HG-U133A

TCF7L2 AKAP7 KIAA0319L

2.23e-041991436740_DN
DrugKetorolac tromethamine [74103-07-4]; Down 200; 10.6uM; MCF7; HT_HG-U133A

CHD3 TCF7L2 AKAP7

2.23e-041991435988_DN
DrugNaftopidil dihydrochloride [57149-08-3]; Down 200; 8.6uM; MCF7; HT_HG-U133A

ALMS1 CHD3 IGFBP3

2.23e-041991437331_DN
DrugTadjakonine [11087-94-8]; Up 200; 7.4uM; MCF7; HT_HG-U133A

TCF7L2 AKAP7 KIAA0319L

2.23e-041991432820_UP
DrugEthynylestradiol 3-methyl ether [72-33-3]; Down 200; 12.8uM; MCF7; HT_HG-U133A

ALMS1 TCF7L2 KIAA0319L

2.23e-041991433346_DN
Drugchlorpromazine hydrochloride; Down 200; 1uM; HL60; HT_HG-U133A

STRN TCF7L2 KIAA0319L

2.26e-042001432677_DN
Drugnordihydroguaiaretic acid; Up 200; 1uM; HL60; HT_HG-U133A

STRN TCF7L2 KIAA0319L

2.26e-042001431164_UP
DrugDrofenine hydrochloride [548-66-3]; Down 200; 11.4uM; PC3; HT_HG-U133A

ALMS1 TCF7L2 AKAP7

2.26e-042001437129_DN
DrugNystatine [1400-61-9]; Down 200; 4.4uM; MCF7; HT_HG-U133A

MEIS2 TCF7L2 AKAP7

2.26e-042001434807_DN
DrugTalampicillin hydrochloride [39878-70-1]; Down 200; 7.8uM; HL60; HT_HG-U133A

RBBP6 TCF7L2 AKAP7

2.26e-042001432954_DN
DrugBenoxinate hydrochloride [5987-82-6]; Down 200; 11.6uM; MCF7; HT_HG-U133A

CHD3 MEIS2 TCF7L2

2.26e-042001431476_DN
DrugSaquinavir mesylate [149845-06-7]; Up 200; 5.2uM; MCF7; HT_HG-U133A

TCF7L1 CHD3 TCF7L2

2.26e-042001436246_UP
Drugmetformin

LEF1 TCF7L1 TCF7L2

3.63e-04235143CID000004091
Diseaseobesity (implicated_via_orthology)

ALMS1 LEF1 TCF7L1 TCF7L2

1.86e-06215134DOID:9970 (implicated_via_orthology)
Diseaseblood phosphate measurement

TCF7L1 AKAP7 USP40

5.52e-05174133EFO_0010972
Diseaseurate measurement, bone density

TCF7L1 STRN TCF7L2 USP40

1.18e-04619134EFO_0003923, EFO_0004531
DiseaseCardiomyopathy, Dilated

ALMS1 TCF7L2

2.00e-0448132C0007193
DiseaseCardiomyopathy, Familial Idiopathic

ALMS1 TCF7L2

2.17e-0450132C1449563
Diseasesitting height ratio

TCF7L2 IGFBP3

2.26e-0451132EFO_0007118
Diseaseneuroimaging measurement, brain volume measurement

STRN TCF7L2 IGFBP3

2.40e-04286133EFO_0004346, EFO_0006930
DiseasePROSTATE CANCER, HEREDITARY, 1

CHD3 TCF7L2

3.13e-0460132C4722327
DiseaseProstate cancer, familial

CHD3 TCF7L2

4.13e-0469132C2931456
Diseaseneuroimaging measurement

STRN MEIS2 TCF7L2 IGFBP3

9.42e-041069134EFO_0004346
Diseasetype 2 diabetes mellitus (implicated_via_orthology)

ALMS1 TCF7L2

9.54e-04105132DOID:9352 (implicated_via_orthology)
Diseaseprostate cancer (is_implicated_in)

TCF7L2 IGFBP3

1.18e-03117132DOID:10283 (is_implicated_in)
Diseasebreast cancer (is_implicated_in)

TCF7L2 IGFBP3

1.93e-03150132DOID:1612 (is_implicated_in)
DiseaseColonic Neoplasms

LEF1 TCF7L2

1.98e-03152132C0009375
DiseaseMalignant tumor of colon

LEF1 TCF7L2

2.16e-03159132C0007102
Diseasecortical surface area measurement

TCF7L1 STRN MEIS2 TCF7L2

2.21e-031345134EFO_0010736
Diseasetype 2 diabetes mellitus (is_implicated_in)

TCF7L2 IGFBP3

2.50e-03171132DOID:9352 (is_implicated_in)
DiseaseMyocardial Ischemia

TCF7L2 IGFBP3

2.64e-03176132C0151744
Diseasediastolic blood pressure, systolic blood pressure

ALMS1 TCF7L1 IGFBP3

2.81e-03670133EFO_0006335, EFO_0006336
Diseasecervical carcinoma

ALMS1 TCF7L1

2.82e-03182132EFO_0001061
DiseaseColorectal Carcinoma

LEF1 TCF7L2 IGFBP3

3.21e-03702133C0009402

Protein segments in the cluster

PeptideGeneStartEntry
INPKKQRKKKNYKNS

CPNE2

266

Q96FN4
DQVKKRKKKRKDYQP

AKAP7

71

Q9P0M2
GYPEDRKLKKNKKNS

ALMS1

3941

Q8TCU4
NYGKKKKRKREKLQE

LEF1

371

Q9UJU2
KRQKGKPKRKSKYKI

KIAA0319L

956

Q8IZA0
DKDKKRQKKRGIFPK

MEIS2

271

O14770
KNKPLDNKGEKRKRK

RBBP6

1136

Q7Z6E9
DPAQPRKYKKKKKEL

CHD3

691

Q12873
RKYKKKKKELQGDGP

CHD3

696

Q12873
DKKGFYKKKQCRPSK

IGFBP3

241

P17936
YKKERKGKKGVKRPN

STRN

336

O43815
RDNYGKKKKRKREKQ

TCF7L1

416

Q9HCS4
DNYGKKKKRKRDKQP

TCF7L2

421

Q9NQB0
KRKKKKKQDYLQGAP

USP40

1141

Q9NVE5
KQKPKKKRRPDSRQY

ZFY

391

P08048