Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionextracellular matrix structural constituent

COL4A4 LAMA5 FBLN2 FBN1 IGFBP7 COLQ SSPOP AGRN FBN3

2.56e-10188449GO:0005201
GeneOntologyMolecularFunctionmethyl-CpG binding

MBD3L5 MBD3L3 MBD3L4 MBD3L2 MBD3L2B

6.69e-0931445GO:0008327
GeneOntologyMolecularFunctionstructural molecule activity

COL4A4 LAMA5 FBLN2 FBN1 IGFBP7 COLQ SSPOP AGRN FBN3

1.17e-04891449GO:0005198
GeneOntologyMolecularFunctionextracellular matrix constituent conferring elasticity

FBLN2 FBN1

3.09e-0412442GO:0030023
GeneOntologyMolecularFunctionendopeptidase activity

ADAMTS10 EEF1AKMT4-ECE2 CORIN ADAMTS4 PRSS53 PRSS12

3.40e-04430446GO:0004175
GeneOntologyMolecularFunctionstructural molecule activity conferring elasticity

FBLN2 FBN1

4.25e-0414442GO:0097493
GeneOntologyMolecularFunctionmetalloendopeptidase activity

ADAMTS10 EEF1AKMT4-ECE2 ADAMTS4

2.34e-03120443GO:0004222
GeneOntologyBiologicalProcessDNA methylation-dependent constitutive heterochromatin formation

MBD3L5 MBD3L3 MBD3L4 MBD3L2 MBD3L2B

4.01e-0844455GO:0006346
GeneOntologyBiologicalProcessfacultative heterochromatin formation

MBD3L5 MBD3L3 MBD3L4 MBD3L2 MBD3L2B

1.26e-0755455GO:0140718
GeneOntologyBiologicalProcessheterochromatin formation

MBD3L5 MBD3L3 MBD3L4 MBD3L2 MBD3L2B

2.74e-05163455GO:0031507
GeneOntologyBiologicalProcessnegative regulation of gene expression, epigenetic

MBD3L5 MBD3L3 MBD3L4 MBD3L2 MBD3L2B

7.80e-05203455GO:0045814
GeneOntologyBiologicalProcessregulation of synaptic assembly at neuromuscular junction

COLQ AGRN

9.71e-057452GO:0008582
GeneOntologyCellularComponentextracellular matrix

ADAMTS10 COL4A4 LAMA5 LAMB4 FBLN2 FBN1 IGFBP7 ADAMTS4 COLQ SSPOP AGRN FBN3

6.94e-096564412GO:0031012
GeneOntologyCellularComponentexternal encapsulating structure

ADAMTS10 COL4A4 LAMA5 LAMB4 FBLN2 FBN1 IGFBP7 ADAMTS4 COLQ SSPOP AGRN FBN3

7.18e-096584412GO:0030312
GeneOntologyCellularComponentcollagen-containing extracellular matrix

ADAMTS10 COL4A4 LAMA5 LAMB4 FBLN2 FBN1 IGFBP7 ADAMTS4 COLQ SSPOP AGRN

9.03e-095304411GO:0062023
GeneOntologyCellularComponentbasement membrane

COL4A4 LAMA5 LAMB4 FBN1 COLQ AGRN

2.06e-07122446GO:0005604
GeneOntologyCellularComponentsynaptic cleft

LAMA5 COLQ AGRN PRSS12

6.68e-0733444GO:0043083
GeneOntologyCellularComponentmicrofibril

ADAMTS10 FBN1 FBN3

2.45e-0613443GO:0001527
HumanPhenoAbnormality of lens shape

ADAMTS10 COL4A4 FBN1

2.93e-0518183HP:0011526
HumanPhenoBroad skull

ADAMTS10 FBN1

3.53e-053182HP:0002682
HumanPhenoMicrospherophakia

ADAMTS10 FBN1

7.05e-054182HP:0030961
HumanPhenoSpherophakia

ADAMTS10 FBN1

1.17e-045182HP:0034375
DomainMeCpG-bd_2/3_C_dom

MBD3L5 MBD3L3 MBD3L4 MBD3L2

9.33e-107444IPR025884
DomainMBD2/MBD3_p55-bd

MBD3L5 MBD3L3 MBD3L4 MBD3L2

9.33e-107444IPR032343
DomainMBD_C

MBD3L5 MBD3L3 MBD3L4 MBD3L2

9.33e-107444PF14048
DomainMBDa

MBD3L5 MBD3L3 MBD3L4 MBD3L2

9.33e-107444PF16564
DomainEGF_1

LAMA5 LAMB4 HEG1 FBLN2 FBN1 SSPOP AGRN FBN3

1.25e-07255448PS00022
DomainEGF_2

LAMA5 LAMB4 HEG1 FBLN2 FBN1 SSPOP AGRN FBN3

1.68e-07265448PS01186
DomainEGF-like_CS

LAMA5 LAMB4 HEG1 FBLN2 FBN1 AGRN FBN3

2.37e-06261447IPR013032
DomainEGF_CA

HEG1 FBLN2 FBN1 AGRN FBN3

9.70e-06122445SM00179
DomainEGF-like_Ca-bd_dom

HEG1 FBLN2 FBN1 AGRN FBN3

1.05e-05124445IPR001881
DomainTSP_1

ADAMTS10 ADAMTS4 SSPOP UNC5B

1.44e-0563444PF00090
DomainFBN

FBN1 FBN3

1.62e-053442IPR011398
DomainTSP1

ADAMTS10 ADAMTS4 SSPOP UNC5B

1.63e-0565444SM00209
DomainTSP1_rpt

ADAMTS10 ADAMTS4 SSPOP UNC5B

1.63e-0565444IPR000884
DomainTSP1

ADAMTS10 ADAMTS4 SSPOP UNC5B

1.63e-0565444PS50092
DomainEGF_3

HEG1 FBLN2 FBN1 SSPOP AGRN FBN3

1.76e-05235446PS50026
DomainEGF

LAMA5 HEG1 FBLN2 FBN1 AGRN FBN3

1.76e-05235446SM00181
DomainEGF-like_dom

LAMA5 HEG1 FBLN2 FBN1 AGRN FBN3

2.44e-05249446IPR000742
DomaincEGF

FBLN2 FBN1 FBN3

3.05e-0526443IPR026823
DomaincEGF

FBLN2 FBN1 FBN3

3.05e-0526443PF12662
DomainGrowth_fac_rcpt_

LAMA5 FBLN2 FBN1 IGFBP7 FBN3

3.18e-05156445IPR009030
DomainEGF_LAM_2

LAMA5 LAMB4 AGRN

4.74e-0530443PS50027
DomainEGF_LAM_1

LAMA5 LAMB4 AGRN

4.74e-0530443PS01248
DomainEGF_CA

HEG1 FBLN2 FBN1 FBN3

4.94e-0586444PF07645
DomainNUT

NUTM2F NUTM2G

5.40e-055442IPR024310
DomainNUT_N

NUTM2F NUTM2G

5.40e-055442IPR024309
DomainNUT

NUTM2F NUTM2G

5.40e-055442PF12881
DomainLaminin_EGF

LAMA5 LAMB4 AGRN

7.57e-0535443PF00053
DomainEGF_Lam

LAMA5 LAMB4 AGRN

7.57e-0535443SM00180
DomainEGF_Ca-bd_CS

HEG1 FBLN2 FBN1 FBN3

7.91e-0597444IPR018097
DomainEGF_CA

HEG1 FBLN2 FBN1 FBN3

8.57e-0599444PS01187
DomainASX_HYDROXYL

HEG1 FBLN2 FBN1 FBN3

8.91e-05100444PS00010
DomainLaminin_EGF

LAMA5 LAMB4 AGRN

9.71e-0538443IPR002049
DomainEGF-type_Asp/Asn_hydroxyl_site

HEG1 FBLN2 FBN1 FBN3

1.12e-04106444IPR000152
DomainTB

FBN1 FBN3

1.13e-047442PF00683
Domain-

FBN1 FBN3

1.51e-0484423.90.290.10
DomainTB

FBN1 FBN3

1.93e-049442PS51364
DomainTB_dom

FBN1 FBN3

1.93e-049442IPR017878
DomainIBR

CUL9 PRKN

4.85e-0414442SM00647
DomainIBR

CUL9 PRKN

4.85e-0414442PF01485
DomainIBR_dom

CUL9 PRKN

5.59e-0415442IPR002867
DomainLaminin_N

LAMA5 LAMB4

6.37e-0416442IPR008211
DomainLAMININ_NTER

LAMA5 LAMB4

6.37e-0416442PS51117
DomainLaminin_N

LAMA5 LAMB4

6.37e-0416442PF00055
DomainLamNT

LAMA5 LAMB4

6.37e-0416442SM00136
DomainTRYPSIN_SER

CORIN PRSS53 PRSS12

1.24e-0390443IPR033116
DomainADAM_spacer1

ADAMTS10 ADAMTS4

1.33e-0323442IPR010294
DomainADAM_spacer1

ADAMTS10 ADAMTS4

1.33e-0323442PF05986
DomainGalactose-bd-like

LAMA5 CUL9 SSPOP

1.41e-0394443IPR008979
DomainPeptidase_M12B_ADAM-TS

ADAMTS10 ADAMTS4

1.45e-0324442IPR013273
DomainSR

CORIN PRSS12

1.57e-0325442SM00202
DomainSRCR_1

CORIN PRSS12

1.70e-0326442PS00420
DomainSRCR_2

CORIN PRSS12

1.70e-0326442PS50287
DomainSRCR-like_dom

CORIN PRSS12

1.70e-0326442IPR017448
DomainTRYPSIN_HIS

CORIN PRSS53 PRSS12

1.83e-03103443IPR018114
DomainSRCR

CORIN PRSS12

1.83e-0327442IPR001190
DomainTRYPSIN_SER

CORIN PRSS53 PRSS12

1.99e-03106443PS00135
DomainTRYPSIN_HIS

CORIN PRSS53 PRSS12

2.04e-03107443PS00134
DomainPeptidase_S1A

CORIN PRSS53 PRSS12

2.38e-03113443IPR001314
DomainTRYPSIN_DOM

CORIN PRSS53 PRSS12

2.51e-03115443PS50240
DomainTryp_SPc

CORIN PRSS53 PRSS12

2.63e-03117443SM00020
DomainTrypsin

CORIN PRSS53 PRSS12

2.89e-03121443PF00089
DomainTrypsin_dom

CORIN PRSS53 PRSS12

2.89e-03121443IPR001254
DomainPeptidase_S1_PA

CORIN PRSS53 PRSS12

3.03e-03123443IPR009003
DomainEGF

HEG1 AGRN FBN3

3.24e-03126443PF00008
DomainKazal_2

IGFBP7 AGRN

3.25e-0336442PF07648
DomainLAM_G_DOMAIN

LAMA5 AGRN

3.61e-0338442PS50025
DomainPeptidase_M12B_N

ADAMTS10 ADAMTS4

3.80e-0339442IPR002870
DomainPep_M12B_propep

ADAMTS10 ADAMTS4

3.80e-0339442PF01562
DomainDISINTEGRIN_1

ADAMTS10 ADAMTS4

4.00e-0340442PS00427
DomainLDLR_class-A_CS

CORIN SSPOP

4.00e-0340442IPR023415
DomainReprolysin

ADAMTS10 ADAMTS4

4.00e-0340442PF01421
DomainADAM_MEPRO

ADAMTS10 ADAMTS4

4.00e-0340442PS50215
DomainDISINTEGRIN_2

ADAMTS10 ADAMTS4

4.00e-0340442PS50214
DomainPeptidase_M12B

ADAMTS10 ADAMTS4

4.00e-0340442IPR001590
DomainDisintegrin_dom

ADAMTS10 ADAMTS4

4.20e-0341442IPR001762
PathwayREACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION

COL4A4 LAMA5 FBLN2 FBN1 ADAMTS4 AGRN FBN3

3.93e-06300327M610
PathwayREACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX

COL4A4 LAMA5 FBN1 ADAMTS4 FBN3

1.46e-05140325M587
PathwayKEGG_ECM_RECEPTOR_INTERACTION

COL4A4 LAMA5 LAMB4 AGRN

3.71e-0584324M7098
PathwayWP_SMALL_CELL_LUNG_CANCER

BAK1 COL4A4 LAMA5 LAMB4

6.27e-0596324M39834
PathwayREACTOME_MOLECULES_ASSOCIATED_WITH_ELASTIC_FIBRES

FBLN2 FBN1 FBN3

7.83e-0537323M27134
PathwayREACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS

ADAMTS10 ADAMTS4 SSPOP

9.19e-0539323M27417
PathwayREACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS

ADAMTS10 ADAMTS4 SSPOP

9.19e-0539323MM15165
PathwayREACTOME_ELASTIC_FIBRE_FORMATION

FBLN2 FBN1 FBN3

1.32e-0444323M26969
PathwayREACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION

COL4A4 FBLN2 FBN1 ADAMTS4 AGRN

2.65e-04258325MM14572
PathwayREACTOME_DISEASES_OF_GLYCOSYLATION

ADAMTS10 ADAMTS4 SSPOP AGRN

2.93e-04143324M27275
PathwayREACTOME_NON_INTEGRIN_MEMBRANE_ECM_INTERACTIONS

COL4A4 LAMA5 AGRN

3.17e-0459323M27218
PathwayPID_INTEGRIN1_PATHWAY

COL4A4 LAMA5 FBN1

4.41e-0466323M18
PathwayREACTOME_DISEASES_ASSOCIATED_WITH_O_GLYCOSYLATION_OF_PROTEINS

ADAMTS10 ADAMTS4 SSPOP

4.82e-0468323M27303
PathwayWP_PRIMARY_FOCAL_SEGMENTAL_GLOMERULOSCLEROSIS_FSGS

COL4A4 LAMA5 AGRN

5.70e-0472323M39403
PathwayWP_PRIMARY_FOCAL_SEGMENTAL_GLOMERULOSCLEROSIS_FSGS

COL4A4 LAMA5 AGRN

5.93e-0473323MM15906
PathwayREACTOME_ECM_PROTEOGLYCANS

COL4A4 LAMA5 AGRN

6.67e-0476323M27219
PathwayKEGG_SMALL_CELL_LUNG_CANCER

COL4A4 LAMA5 LAMB4

8.94e-0484323M3228
PathwayREACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS

COL4A4 FBN1 AGRN

9.25e-0485323M16441
PathwayWP_HYPOTHESIZED_PATHWAYS_IN_PATHOGENESIS_OF_CARDIOVASCULAR_DISEASE

FBN1 FBN3

1.45e-0325322M39713
PathwayREACTOME_O_LINKED_GLYCOSYLATION

ADAMTS10 ADAMTS4 SSPOP

1.89e-03109323MM15164
PathwayREACTOME_O_LINKED_GLYCOSYLATION

ADAMTS10 ADAMTS4 SSPOP

2.00e-03111323M27416
PathwayREACTOME_LAMININ_INTERACTIONS

COL4A4 LAMA5

2.09e-0330322M27216
PathwayREACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX

COL4A4 FBN1 ADAMTS4

2.15e-03114323MM14571
PathwayREACTOME_DISEASES_OF_METABOLISM

ADAMTS10 ADAMTS4 SSPOP AGRN

2.35e-03250324M27554
PathwayREACTOME_MOLECULES_ASSOCIATED_WITH_ELASTIC_FIBRES

FBLN2 FBN1

2.37e-0332322MM14854
PathwayREACTOME_ELASTIC_FIBRE_FORMATION

FBLN2 FBN1

3.51e-0339322MM14601
Pubmed

Haploid male germ cell- and oocyte-specific Mbd3l1 and Mbd3l2 genes are dispensable for early development, fertility, and zygotic DNA demethylation in the mouse.

MBD3L5 MBD3L3 MBD3L4 MBD3L2 MBD3L2B

1.94e-14646518942147
Pubmed

MBD3L1 and MBD3L2, two new proteins homologous to the methyl-CpG-binding proteins MBD2 and MBD3: characterization of MBD3L1 as a testis-specific transcriptional repressor.

MBD3L5 MBD3L3 MBD3L4 MBD3L2 MBD3L2B

1.94e-14646512504854
Pubmed

MBD3L2 interacts with MBD3 and components of the NuRD complex and can oppose MBD2-MeCP1-mediated methylation silencing.

MBD3L5 MBD3L3 MBD3L4 MBD3L2 MBD3L2B

9.62e-121546515701600
Pubmed

Mesangial cells organize the glomerular capillaries by adhering to the G domain of laminin alpha5 in the glomerular basement membrane.

COL4A4 LAMA5 FBLN2 AGRN

1.90e-091346412682087
Pubmed

The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices.

COL4A4 LAMA5 FBLN2 FBN1 IGFBP7 COLQ AGRN

2.37e-0916746722159717
Pubmed

Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.

COL4A4 LAMA5 FBLN2 FBN1 IGFBP7 SSPOP AGRN

3.28e-0917546728071719
Pubmed

Comparative proteomic analysis of supportive and unsupportive extracellular matrix substrates for human embryonic stem cell maintenance.

LAMA5 FBLN2 FBN1 ADAMTS4 AGRN

6.55e-095046523658023
Pubmed

Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver.

COL4A4 LAMA5 FBLN2 FBN1 IGFBP7 COLQ

5.32e-0815346625037231
Pubmed

Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation.

LAMA5 FBLN2 FBN1 IGFBP7 AGRN

1.90e-079746527559042
Pubmed

Lack of Fgf18 causes abnormal clustering of motor nerve terminals at the neuromuscular junction with reduced acetylcholine receptor clusters.

IGFBP7 COLQ AGRN

7.80e-071446329323161
Pubmed

Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins.

LAMA5 FBLN2 FBN1 IGFBP7 AGRN

1.45e-0614646527068509
Pubmed

Confocal laser scanning analysis of the association of fibulin-2 with fibrillin-1 and fibronectin define different stages of skin regeneration.

FBLN2 FBN1

1.71e-0624629886271
Pubmed

ADAMTS10 protein interacts with fibrillin-1 and promotes its deposition in extracellular matrix of cultured fibroblasts.

ADAMTS10 FBN1

1.71e-06246221402694
Pubmed

Fibrillin-1 and fibulin-2 interact and are colocalized in some tissues.

FBLN2 FBN1

1.71e-0624628702639
Pubmed

Homozygosity mapping of a Weill-Marchesani syndrome locus to chromosome 19p13.3-p13.2.

ADAMTS10 FBN3

1.71e-06246211941487
Pubmed

Destabilization of the neuromuscular junction by proteolytic cleavage of agrin results in precocious sarcopenia.

AGRN PRSS12

1.71e-06246221885656
Pubmed

Neurotrypsin cleaves agrin locally at the synapse.

AGRN PRSS12

1.71e-06246218230682
Pubmed

The C-Terminal Fragment of Agrin (CAF), a Novel Marker of Renal Function, Is Filtered by the Kidney and Reabsorbed by the Proximal Tubule.

AGRN PRSS12

1.71e-06246227380275
Pubmed

Coincident pre- and postsynaptic activation induces dendritic filopodia via neurotrypsin-dependent agrin cleavage.

AGRN PRSS12

1.71e-06246219303856
Pubmed

Characterization of a Cul9-Parkin double knockout mouse model for Parkinson's disease.

CUL9 PRKN

1.71e-06246233037272
Pubmed

Three novel mutations of the fibrillin-1 gene and ten single nucleotide polymorphisms of the fibrillin-3 gene in Marfan syndrome patients.

FBN1 FBN3

1.71e-06246215221638
Pubmed

Specific cleavage of agrin by neurotrypsin, a synaptic protease linked to mental retardation.

AGRN PRSS12

1.71e-06246217586728
Pubmed

Genes encoding agrin (AGRN) and neurotrypsin (PRSS12) are associated with muscle mass, strength and plasma C-terminal agrin fragment concentration.

AGRN PRSS12

1.71e-06246236609795
Pubmed

Transcriptome-based systematic identification of extracellular matrix proteins.

COL4A4 LAMA5 FBLN2 AGRN

3.74e-067946418757743
Pubmed

Parkin inhibits BAK and BAX apoptotic function by distinct mechanisms during mitophagy.

BAK1 PRKN

5.13e-06346230573668
Pubmed

Cleavage of Fibulin-2 by the aggrecanases ADAMTS-4 and ADAMTS-5 contributes to the tumorigenic potential of breast cancer cells.

FBLN2 ADAMTS4

5.13e-06346228099917
Pubmed

Fibulin-2 binds to the short arms of laminin-5 and laminin-1 via conserved amino acid sequences.

LAMA5 FBLN2

5.13e-0634629006922
Pubmed

Adamts10 inactivation in mice leads to persistence of ocular microfibrils subsequent to reduced fibrillin-2 cleavage.

ADAMTS10 FBN1

5.13e-06346230201140
Pubmed

Identification of far upstream element-binding protein-1 as an authentic Parkin substrate.

CUL9 PRKN

5.13e-06346216672220
Pubmed

Proteomics characterization of extracellular space components in the human aorta.

LAMA5 FBN1 IGFBP7 AGRN

9.95e-0610146420551380
Pubmed

Heparin/heparan sulfate controls fibrillin-1, -2 and -3 self-interactions in microfibril assembly.

FBN1 FBN3

1.03e-05446225034023
Pubmed

Fibulin-2 and fibulin-5 alterations in tsk mice associated with disorganized hypodermal elastic fibers and skin tethering.

FBLN2 FBN1

1.03e-05446215610515
Pubmed

The collagen ColQ binds to LRP4 and regulates the activation of the Muscle-Specific Kinase-LRP4 receptor complex by agrin at the neuromuscular junction.

COLQ AGRN

1.03e-05446237356721
Pubmed

Weill-Marchesani Syndrome

ADAMTS10 FBN1

1.03e-05446220301293
Pubmed

An agrin minigene rescues dystrophic symptoms in a mouse model for congenital muscular dystrophy.

LAMA5 AGRN

1.03e-05446211565031
Pubmed

A role for BCL2L13 and autophagy in germline purifying selection of mtDNA.

PRKN ULK2

1.71e-05546236608143
Pubmed

Extracellular matrix of secondary lymphoid organs impacts on B-cell fate and survival.

LAMA5 AGRN

2.56e-05646223847204
Pubmed

Laminin alpha1 globular domains 4-5 induce fetal development but are not vital for embryonic basement membrane assembly.

LAMA5 AGRN

2.56e-05646215668394
Pubmed

Latent transforming growth factor beta-binding proteins and fibulins compete for fibrillin-1 and exhibit exquisite specificities in binding sites.

FBLN2 FBN1

2.56e-05646219349279
Pubmed

Presenilins regulate neurotrypsin gene expression and neurotrypsin-dependent agrin cleavage via cyclic AMP response element-binding protein (CREB) modulation.

AGRN PRSS12

3.58e-05746224145027
Pubmed

EMILIN proteins are novel extracellular constituents of the dentin-pulp complex.

FBLN2 FBN1

4.77e-05846232948785
Pubmed

Fras1 deficiency results in cryptophthalmos, renal agenesis and blebbed phenotype in mice.

LAMA5 AGRN

4.77e-05846212766770
Pubmed

Gelatinase B (MMP-9) is not essential in the normal kidney and does not influence progression of renal disease in a mouse model of Alport syndrome.

COL4A4 LAMA5

6.12e-05946210880400
Pubmed

ADAMTS: a novel family of extracellular matrix proteases.

ADAMTS10 ADAMTS4

7.65e-051046211167130
Pubmed

Basement membrane distortions impair lung lobation and capillary organization in the mouse model for fraser syndrome.

LAMA5 AGRN

7.65e-051046215623520
Pubmed

Distribution of fibronectin, type I collagen, type IV collagen, and laminin in the cardiac jelly of the mouse embryonic heart with retinoic acid-induced complete transposition of the great arteries.

COL4A4 FBN1

7.65e-05104629415455
Pubmed

Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury.

FBLN2 SSPOP AGRN

8.53e-056446322261194
Pubmed

Binding of mouse and human fibulin-2 to extracellular matrix ligands.

COL4A4 FBLN2

9.34e-05114627500359
Pubmed

Anuria, omphalocele, and perinatal lethality in mice lacking the CD34-related protein podocalyxin.

COL4A4 LAMA5

9.34e-051146211435469
Pubmed

Molecular dissection of laminin alpha 5 in vivo reveals separable domain-specific roles in embryonic development and kidney function.

LAMA5 AGRN

1.12e-041246216750824
Pubmed

Insights on ADAMTS proteases and ADAMTS-like proteins from mammalian genetics.

ADAMTS10 ADAMTS4

1.12e-041246225770910
Pubmed

DIO3 protects against thyrotoxicosis-derived cranio-encephalic and cardiac congenital abnormalities.

IGFBP7 HR

1.32e-041346236166296
Pubmed

O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation.

ADAMTS10 ADAMTS4 SSPOP

1.37e-047546320637190
Pubmed

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

COL4A4 LAMA5 RNF213 HEG1 FBN1 IGFBP7 AGRN SLC39A13

1.60e-04120146835696571
Pubmed

Defective glomerulogenesis in the absence of laminin alpha5 demonstrates a developmental role for the kidney glomerular basement membrane.

COL4A4 LAMA5

1.78e-041546210625553
Pubmed

Localization of basement membrane-associated protein isoforms during development of the ocular surface of mouse eye.

COL4A4 LAMA5

1.78e-04154629264260
Pubmed

Cytoplasmic Metadherin (MTDH) provides survival advantage under conditions of stress by acting as RNA-binding protein.

COL4A4 LAMA5 CUL9 RNF213

1.86e-0421446422199357
Pubmed

ADAMTS18 Deficiency Affects Neuronal Morphogenesis and Reduces the Levels of Depression-like Behaviors in Mice.

LAMA5 ADAMTS4

2.03e-041646230579834
Pubmed

Amplification of extracellular matrix and oncogenes in tat-transfected human salivary gland cell lines with expression of laminin, fibronectin, collagens I, III, IV, c-myc and p53.

LAMA5 LAMB4

2.58e-041846211311202
Pubmed

Proteolysis of fibrillin-2 microfibrils is essential for normal skeletal development.

ADAMTS10 FBN1

2.58e-041846235503090
Pubmed

ADAMTS18-fibronectin interaction regulates the morphology of liver sinusoidal endothelial cells.

LAMA5 FBN1

2.58e-041846239040056
Pubmed

Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity.

CUL9 RNF213 PRKN

2.75e-049546329643511
Pubmed

Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c.

FBLN2 FBN1 IGFBP7 AGRN

3.25e-0424846424006456
Pubmed

Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

CUL9 ADAMTS4 ULK2

3.39e-041024639734811
Pubmed

PDGFRβ regulates craniofacial development through homodimers and functional heterodimers with PDGFRα.

COL4A4 LAMA5

3.54e-042146227856617
Pubmed

Atrx deficiency induces telomere dysfunction, endocrine defects, and reduced life span.

TSHR IGFBP7

5.04e-042546223563309
Pubmed

Cannabinoid inhibits HIV-1 Tat-stimulated adhesion of human monocyte-like cells to extracellular matrix proteins.

COL4A4 LAMA5

5.45e-042646224742657
Pubmed

Adamts18 modulates the development of the aortic arch and common carotid artery.

LAMA5 FBN1

5.45e-042646234189436
Pubmed

Congenital Myasthenic Syndromes Overview

COLQ AGRN

5.45e-042646220301347
Pubmed

Basement membrane assembly of the integrin α8β1 ligand nephronectin requires Fraser syndrome-associated proteins.

LAMA5 AGRN

6.79e-042946222613833
Pubmed

Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.

LAMA5 FBN1 AGRN

7.68e-0413546328675934
Pubmed

Protein interactome reveals converging molecular pathways among autism disorders.

LAMA5 FBLN2 FBN1 ZCCHC2 AGRN

8.45e-0456046521653829
Pubmed

Activation of beta-catenin signaling programs embryonic epidermis to hair follicle fate.

LAMA5 UNC5B

8.80e-043346218480165
Pubmed

Large-scale identification of genes implicated in kidney glomerulus development and function.

COL4A4 LAMA5

9.35e-043446216498405
Pubmed

Adamts18 Deficiency Causes Spontaneous SMG Fibrogenesis in Adult Mice.

LAMA5 FBN1

1.11e-033746234323105
Pubmed

Epicardial cell shape and maturation are regulated by Wt1 via transcriptional control of Bmp4.

FBLN2 UPK3B

1.17e-033846231624071
Pubmed

Canonical Wnt signaling regulates smooth muscle precursor development in the mouse ureter.

FBLN2 UPK3B

1.17e-033846222833126
Pubmed

Thyroid follicle development requires Smad1/5- and endothelial cell-dependent basement membrane assembly.

COL4A4 LAMA5

1.29e-034046227068110
Cytoband19p13.2

ADAMTS10 MBD3L5 MBD3L3 MBD3L4 MBD3L2 MBD3L2B

1.14e-0722946619p13.2
CytobandEnsembl 112 genes in cytogenetic band chr19p13

ADAMTS10 MBD3L5 MBD3L3 MBD3L4 MBD3L2 FBN3 MBD3L2B

1.38e-05797467chr19p13
GeneFamilyProteases, serine

CORIN PRSS53 PRSS12

1.38e-0463293738
GeneFamilyLaminin subunits

LAMA5 LAMB4

1.62e-0412292626
GeneFamilyADAM metallopeptidases with thrombospondin type 1 motif

ADAMTS10 ADAMTS4

4.18e-041929250
GeneFamilyBlood group antigens|CD molecules|I-set domain containing|Immunoglobulin like domain containing

ALPK3 IGFBP7 UNC5B

2.14e-03161293593
CoexpressionNABA_CORE_MATRISOME

COL4A4 LAMA5 LAMB4 FBLN2 FBN1 IGFBP7 COLQ SSPOP AGRN FBN3

3.17e-112754510M5884
CoexpressionNABA_ECM_GLYCOPROTEINS

LAMA5 LAMB4 FBLN2 FBN1 IGFBP7 COLQ SSPOP AGRN FBN3

4.27e-11196459M3008
CoexpressionNABA_BASEMENT_MEMBRANES

COL4A4 LAMA5 LAMB4 COLQ AGRN

7.46e-0940455M5887
CoexpressionMARTINEZ_RB1_AND_TP53_TARGETS_DN

LAMA5 MBD3L5 MBD3L3 MBD3L4 FBLN2 ADAMTS4 PRSS12 MBD3L2 UNC5B MBD3L2B HR

9.46e-096504511MM1042
CoexpressionNABA_MATRISOME

ADAMTS10 COL4A4 LAMA5 LAMB4 FBLN2 FBN1 IGFBP7 ADAMTS4 COLQ SSPOP AGRN PRSS12 FBN3

1.07e-0810264513M5889
CoexpressionNABA_CORE_MATRISOME

COL4A4 LAMA5 FBLN2 FBN1 IGFBP7 COLQ SSPOP AGRN

1.77e-08270458MM17057
CoexpressionNABA_ECM_GLYCOPROTEINS

LAMA5 FBLN2 FBN1 IGFBP7 COLQ SSPOP AGRN

3.51e-08191457MM17059
CoexpressionMARTINEZ_TP53_TARGETS_DN

LAMA5 MBD3L5 MBD3L3 MBD3L4 ADAMTS4 PRSS12 MBD3L2 UNC5B MBD3L2B HR

1.36e-076594510MM1040
CoexpressionTRAVAGLINI_LUNG_ALVEOLAR_EPITHELIAL_TYPE_1_CELL

COL4A4 RNF213 HEG1 IGFBP7 RNF128 AGRN SLC39A13 UPK3B

3.04e-07391458M41659
CoexpressionNABA_MATRISOME

ADAMTS10 COL4A4 LAMA5 FBLN2 FBN1 IGFBP7 ADAMTS4 COLQ SSPOP AGRN PRSS12

7.87e-0710084511MM17056
CoexpressionMARTINEZ_RB1_TARGETS_DN

LAMA5 MBD3L5 MBD3L3 MBD3L4 ADAMTS4 PRSS12 MBD3L2 UNC5B MBD3L2B

1.04e-06630459MM1038
CoexpressionNABA_MATRISOME_HGSOC_OMENTAL_METASTASIS

COL4A4 FBLN2 IGFBP7 AGRN

3.22e-0659454M47993
CoexpressionMARTINEZ_RB1_AND_TP53_TARGETS_DN

LAMA5 FBLN2 ADAMTS4 PRSS12 UNC5B MBD3L2B HR

7.52e-05610457M3854
ToppCell367C-Epithelial_cells-Epithelial-I_(AT1)-|367C / Donor, Lineage, Cell class and subclass (all cells)

COL4A4 LAMA5 RNF128 AGRN ASAH2 UPK3B

2.53e-08174466edf839d79ac58921f4e788f3b2cb2ae0d6af4b9e
ToppCell367C-Epithelial_cells-Epithelial-I_(AT1)|367C / Donor, Lineage, Cell class and subclass (all cells)

COL4A4 LAMA5 RNF128 AGRN ASAH2 UPK3B

2.53e-0817446665539f69100db0b7d90b1b39ee15ab8281f86461
ToppCellAT1_cells-SSc-ILD_01|World / lung cells shred on cell class, cell subclass, sample id

COL4A4 LAMA5 IGFBP7 AGRN FBN3 UPK3B

3.88e-08187466f1dda349335e08dbfc8395d373924037f5ad2fd6
ToppCellAT1_cells-Donor_02|World / lung cells shred on cell class, cell subclass, sample id

COL4A4 LAMA5 HEG1 IGFBP7 AGRN UPK3B

4.54e-081924660444f9e9cef7403e220e862b5a787443d3f5c9ac
ToppCellEpithelial_cells-AT1_cells|Epithelial_cells / lung cells shred on cell class, cell subclass, sample id

COL4A4 LAMA5 HEG1 IGFBP7 AGRN UPK3B

5.13e-081964666c99d29162848161c1f166a032320f87a5d5a631
ToppCellnormal_Lung-Epithelial_cells-AT1|Epithelial_cells / Location, Cell class and cell subclass

COL4A4 LAMA5 HEG1 IGFBP7 AGRN UPK3B

5.29e-081974667d19b93d6853828e2a036e37c4887edb1de4503c
ToppCellASK428-Epithelial-Type_1|Epithelial / Donor, Lineage and Cell class of Lung cells from Dropseq

COL4A4 LAMA5 HEG1 IGFBP7 RNF128 UPK3B

5.45e-081984660047a9ef7684230ac5179efea94461480e90bdaf
ToppCell(7)_Epithelial_cells-(7)_Epithelial-I_(AT1)|(7)_Epithelial_cells / Lung cell shreds - cell class (v4) and cell subclass (v4)

COL4A4 LAMA5 HEG1 AGRN FBN3 UPK3B

5.61e-081994665a002d49a8b84c158f7b4d7a3e78e6a937757bb7
ToppCellTransplant_Alveoli_and_parenchyma-Epithelial-Type_1_alveolar|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X

COL4A4 LAMA5 HEG1 AGRN UPK3B

6.51e-0716046558ed3a074932ccc951e07868dfdc61b99ae1cc2b
ToppCellAT1_cells-HP_01|World / lung cells shred on cell class, cell subclass, sample id

COL4A4 LAMA5 IGFBP7 AGRN UPK3B

1.04e-06176465458720776b0151cd55acc352d509599cb62f0ca8
ToppCellAT1_cells-Donor_01|World / lung cells shred on cell class, cell subclass, sample id

COL4A4 LAMA5 IGFBP7 AGRN UPK3B

1.16e-06180465e1964002681f80d8d62406b6ee52a01e1829ccf2
ToppCellmetastatic_Brain-Fibroblasts-Myofibroblasts|metastatic_Brain / Location, Cell class and cell subclass

CORIN FBN1 PLPPR4 IGFBP7 UNC5B

1.20e-06181465bd0b5f74f9c81ec0f1592710774a4fdf33d9d5a9
ToppCell343B-Epithelial_cells-Epithelial-I_(AT1)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

COL4A4 LAMA5 HEG1 AGRN UPK3B

1.30e-06184465c7073d1b2c4fdb154d87678b92a0629c02116972
ToppCell343B-Epithelial_cells-Epithelial-I_(AT1)-|343B / Donor, Lineage, Cell class and subclass (all cells)

COL4A4 LAMA5 AGRN FBN3 UPK3B

1.30e-06184465bde4eaabd3e9bdaed23867d23a919b9d84b52d4b
ToppCell343B-Epithelial_cells-Epithelial-I_(AT1)|343B / Donor, Lineage, Cell class and subclass (all cells)

COL4A4 LAMA5 AGRN FBN3 UPK3B

1.30e-06184465cb15d6bae52c5ec251c2235859dc7e65f630ae23
ToppCell343B-Epithelial_cells-Epithelial-I_(AT1)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

COL4A4 LAMA5 HEG1 AGRN UPK3B

1.30e-061844651ed558a88215b248431c524ea16f13d9022ae98c
ToppCellE12.5-Mesenchymal-mesenchymal_fibroblast-mesothelial_cell_of_visceral_pleura|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

COL4A4 LAMA5 RNF213 FBLN2 UPK3B

1.37e-061864651587667e5084ac43505d027af925ba711e228150
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

COL4A4 LAMA5 AGRN FBN3 UPK3B

1.40e-061874654ae7465174e0295d2c3b614b321a3b2f514dd22a
ToppCellE17.5-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_artery|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

HEG1 FBLN2 FBN1 AGRN UNC5B

1.44e-0618846559f276e23c8380bae57d7ecca3a8b83df4bc150b
ToppCellLAM-Epithelial-AT1|Epithelial / Condition, Lineage and Cell class

COL4A4 LAMA5 HEG1 AGRN UPK3B

1.56e-061914653457e15d1e9b36a78363d46b320c4ec46b40290a
ToppCell18-Airway-Epithelial-Bud_tip_adjacent|Airway / Age, Tissue, Lineage and Cell class

COL4A4 LAMA5 IGFBP7 FBN3 UPK3B

1.68e-06194465b45f1e80074a19245bc5dc4b3a583419a1904404
ToppCellnormal_Lung-Epithelial_cells-AT1|normal_Lung / Location, Cell class and cell subclass

COL4A4 LAMA5 RNF128 AGRN UPK3B

1.72e-06195465569d1ebc5a5aa110a2430b096755ae35354040c4
ToppCellAT1_cells|World / lung cells shred on cell class, cell subclass, sample id

COL4A4 LAMA5 HEG1 AGRN UPK3B

1.72e-06195465792d6a49b0a875a00569071183d195287a9925c5
ToppCell356C-Epithelial_cells-Epithelial-I_(AT1)-|356C / Donor, Lineage, Cell class and subclass (all cells)

COL4A4 LAMA5 AGRN FBN3 UPK3B

1.72e-06195465b65511770ed67f7447847e2187555b362988af45
ToppCellwk_15-18-Epithelial-Distal_epithelial-type_II_pneumocyte|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

COL4A4 LAMA5 AGRN FBN3 UPK3B

1.72e-061954650e3aac1b1a1fd483f5fb9a394eb90c0e1ce63542
ToppCell356C-Epithelial_cells-Epithelial-I_(AT1)|356C / Donor, Lineage, Cell class and subclass (all cells)

COL4A4 LAMA5 AGRN FBN3 UPK3B

1.72e-0619546507a3ef6b0f1201fe2bcb9ea426b8f7a69beb4904
ToppCellwk_20-22-Epithelial-Distal_epithelial|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

COL4A4 LAMA5 AGRN FBN3 UPK3B

1.77e-06196465cd507ee2baf4f52d6498811b3510d3164b56311f
ToppCell(7)_Epithelial-I_(AT1)|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

COL4A4 LAMA5 AGRN FBN3 UPK3B

1.77e-06196465150554fa06868d29b0608189862eef6505ba757f
ToppCellwk_20-22-Epithelial-Distal_epithelial-type_I_pneumocyte|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

COL4A4 LAMA5 AGRN FBN3 UPK3B

1.77e-06196465e24a7aaf41793abba66c1189d933ca05b14c1af9
ToppCellwk_15-18-Epithelial-Airway_epithelial_progenitor|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

COL4A4 LAMA5 AGRN FBN3 UPK3B

1.86e-06198465c477405b093f4e5374e57bcacf1fb204a0f7eb3b
ToppCellTracheal-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_systemic_arterial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ALPK3 ADAMTS10 LAMA5 IGFBP7 ADAMTS4

1.86e-061984657dd874b09c81cc512ccc1e9b65f290a5f94d736e
ToppCellEpithelial_cells-AT1-AT2_cells|Epithelial_cells / lung cells shred on cell class, cell subclass, sample id

COL4A4 LAMA5 HEG1 AGRN UPK3B

1.86e-06198465fbc46b20bcd44f2083170aacbc6f5dd00fba685c
ToppCellfacs-Lung-Endomucin-24m-Lymphocytic-Natural_Killer_T_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AGXT2 CUL9 RNF128 SLC39A13

2.18e-051594647619d0d49738dd08daf01b42664691a5323aa793
ToppCellfacs-Lung-Endomucin-24m-Lymphocytic-mature_NK_T_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AGXT2 CUL9 RNF128 SLC39A13

2.18e-051594644000ed0d3b7d488722bcd0042fa2ff4405aaab82
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_ILC-NK_cell-NK_c02-NCAM1|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

ADAMTS10 COL4A4 HEG1 PRSS12

2.41e-051634641c014e373667be290d7fb5d24c06c6f313ac8fa3
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Crispld2_Htr2c|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

LAMA5 IGFBP7 RNF128 UNC5B

2.52e-05165464c6b23013d77fa9aa967b76e451c8e42b0a657c30
ToppCellControl-Epithelial_cells-ECM-high_epithelial|Control / group, cell type (main and fine annotations)

COL4A4 LAMA5 HEG1 IGFBP7

2.84e-05170464e2023d66e70983c87dacbd6181d3426488d1fc57
ToppCell367C-Lymphocytic-NK_cells-NK_cell_D|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

LAMA5 PRKN FBLN2 COLQ

2.90e-05171464943fbca8a6ac04052a2a85aca7b21a3461cd96f7
ToppCellPND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

AGXT2 FBLN2 PRSS12 UPK3B

3.04e-0517346430d67738633493d47f06ae452424382f069b6c0a
ToppCellwk_15-18-Epithelial-Distal_epithelial-type_I_pneumocyte|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

COL4A4 LAMA5 AGRN UPK3B

3.11e-051744642cd6638b361ca05ab83d09ce657194aed97873b7
ToppCellAT1-AT2_cells-Donor_06|World / lung cells shred on cell class, cell subclass, sample id

COL4A4 COLQ RNF128 UPK3B

3.18e-05175464bdd85ba280648a0283c1984662a34c7b840f64dd
ToppCellAT1_cells-SSc-ILD_02|World / lung cells shred on cell class, cell subclass, sample id

COL4A4 LAMA5 IGFBP7 UPK3B

3.25e-051764644a30bb771297b30926fb98e2b5ec0dbdc46feac7
ToppCelltumor_Lymph_Node_/_Brain-Fibroblasts-COL13A1+_matrix_FBs|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass

FBLN2 FBN1 PLPPR4 IGFBP7

3.25e-05176464510f9a14dc1c151d24d079e0cc004cdf4f86336c
ToppCellE18.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

HEG1 FBLN2 FBN1 UNC5B

3.25e-0517646427e6b3ae41068d6cfdda3d46da7df2a27567140e
ToppCellE18.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

HEG1 FBLN2 FBN1 UNC5B

3.25e-05176464d6a5470af9592f34a741265f2ea9651c05c3add3
ToppCellTCGA-Ovary-Primary_Tumor-Ovarian_Carcinoma-Serous_Cystadenocarcinoma-6|TCGA-Ovary / Sample_Type by Project: Shred V9

ADAMTS10 HEG1 FBN1 ADAMTS4

3.39e-05178464142879e9393e721f9b05a6bb46995c9d6d713c95
ToppCellAT1_cells-Cryobiopsy_01|World / lung cells shred on cell class, cell subclass, sample id

COL4A4 LAMA5 AGRN UPK3B

3.47e-051794641603117b52623663458a977c94bf7f9f6c1114b8
ToppCellTransplant_Alveoli_and_parenchyma-Epithelial-Type_1_alveolar|Transplant_Alveoli_and_parenchyma / Tissue, Lineage and Cell class of Lung Cells from 10X

COL4A4 LAMA5 AGRN UPK3B

3.47e-05179464d5763912a4ce7188535675e338799b856edb9dda
ToppCellLA-01._Fibroblast_I|LA / Chamber and Cluster_Paper

COL4A4 FBLN2 FBN1 IGFBP7

3.47e-05179464dcb6ec9ae72b13fe388b72dace2815293fafe8ee
ToppCellAT1_cells-Donor_08|World / lung cells shred on cell class, cell subclass, sample id

COL4A4 LAMA5 AGRN UPK3B

3.55e-051804642d52cb5f77dde0e3dccac1333d4ec67ec680fcb2
ToppCellAT1-AT2_cells-Donor_05|World / lung cells shred on cell class, cell subclass, sample id

COL4A4 LAMA5 AGRN UPK3B

3.62e-05181464ca23ce4f2c7b684d8ddd0e8619b3b696023d75e3
ToppCellBasal|World / shred by cell class for mouse tongue

LAMA5 HEG1 IGFBP7 AGRN

3.78e-05183464c6729a207526ff4aa48176207b9353176f631fea
ToppCell3'-Adult-SmallIntestine-Endothelial|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

HEG1 FBLN2 IGFBP7 ADAMTS4

3.78e-05183464f8212bf8a8b8312434ae030261c558c147f61747
ToppCellIPF-Epithelial-ATI|World / Disease state, Lineage and Cell class

COL4A4 LAMA5 AGRN UPK3B

3.78e-0518346431fef35ecf30162662f24d335d8f0cceacc07039
ToppCellE15.5-Mesenchymal-mesenchymal_fibroblast-mesothelial_cell_of_visceral_pleura|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

COL4A4 FBLN2 IGFBP7 UPK3B

3.78e-05183464274f274cf60daa30d6a4cd603a3af7823bfb8016
ToppCell3'-Adult-SmallIntestine-Endothelial-blood_vessel_EC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

HEG1 FBLN2 IGFBP7 ADAMTS4

3.78e-05183464858682df5592c6856487487a7baabd6e60e63a38
ToppCellIPF-Epithelial-ATI|IPF / Disease state, Lineage and Cell class

COL4A4 LAMA5 AGRN UPK3B

3.78e-05183464c0a3541c45bd0c587603521f392f42dd86c3c35b
ToppCellAT1-AT2_cells-Donor_02|World / lung cells shred on cell class, cell subclass, sample id

COL4A4 LAMA5 HEG1 UPK3B

3.78e-051834646821dca076318115d360ff426eb1218cfe104063
ToppCellfacs-Trachea-24m-Epithelial-glandular_epithelial|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

AGXT2 LAMA5 TSHR RNF128

3.86e-0518446461caaa31975e05c9a6512079c791fed5a9e2d39f
ToppCellE17.5-Mesenchymal-mesenchymal_fibroblast-mesothelial_cell_of_visceral_pleura|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

COL4A4 PLPPR4 PRSS12 UPK3B

3.86e-05184464607b55022de21ddb6a2d75e085df76df7abf6624
ToppCellfacs-Trachea-24m-Epithelial-glandular_epithelial-lung_secretory_cell|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

AGXT2 LAMA5 TSHR RNF128

3.86e-0518446403da0f0f89f1ca5a3ccca1e22972f3129464e68e
ToppCell5'-GW_trimst-2-LymphNode-Mesenchymal-fibroblastic-Stromal_3_(C7+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FBLN2 FBN1 PLPPR4 IGFBP7

3.86e-051844644d4d8f3f44c67d74c57e7af7b7c158f0157b2f49
ToppCellfacs-Trachea-24m-Epithelial-glandular_epithelial-lung_secretory_cell-mucous|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

AGXT2 LAMA5 TSHR RNF128

3.86e-051844649ed2a65a4ca0ebbbb89ace61027522f93369843d
ToppCellAdult-Mesenchymal-matrix_fibroblast_2_cell-D231|Adult / Lineage, Cell type, age group and donor

ADAMTS10 FBLN2 FBN1 IGFBP7

3.95e-05185464fb6bd7e849ecf4ed9cd9c4e2a946a2d12d62f804
ToppCellTCGA-Kidney-Primary_Tumor-Renal_Cell_Carcinoma-Kidney_Clear_Cell_Renal_Carcinoma-2|TCGA-Kidney / Sample_Type by Project: Shred V9

FBN1 PLPPR4 ADAMTS4 UNC5B

4.03e-051864641e6526fc9e9381b7ace864588cc7bd80194338d6
ToppCellEpithelial-alveolar_epithelial_cell_type_1|World / Lineage, Cell type, age group and donor

COL4A4 LAMA5 AGRN FBN3

4.03e-0518646409d95daa3387a4814cffaa4b798cc2810c3759d0
ToppCell5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts-Alveolar_fibroblasts_L.2.1.1.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FBLN2 FBN1 PLPPR4 ADAMTS4

4.03e-051864645473283fb95cee556b1f6934cf72169b676b5bcc
ToppCell3'-Adult-Appendix-Endothelial|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ALPK3 LAMA5 HEG1 FBLN2

4.11e-05187464ec98d5e480b08854dfd0ba6b1dc6610455f90640
ToppCellfacs-Lung-18m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l25-31|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

COL4A4 FBLN2 FBN1 DNAH1

4.11e-05187464fa8f221b4c2df61eadaa9c77e4cf45848b00330b
ToppCellfacs-Pancreas-Exocrine-24m-Mesenchymal-pancreatic_stellate_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ALPK3 FBLN2 FBN1 ADAMTS4

4.11e-0518746490a1078b0303799fba5d2ca4fa12076fd75b78b1
ToppCellfacs-Trachea-nan-24m-Mesenchymal-fibroblast|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HEG1 FBLN2 FBN1 IGFBP7

4.11e-05187464b930d5f7d410ac1f340babec5c937388f64cafc0
ToppCell3'-Adult-Appendix-Endothelial-blood_vessel_EC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ALPK3 LAMA5 HEG1 FBLN2

4.11e-0518746437d8ee5c8bd6324749e5a2adef1d0482c75da80c
ToppCellfacs-Pancreas-Exocrine-24m-Mesenchymal|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ALPK3 FBLN2 FBN1 ADAMTS4

4.11e-051874640f90bce2087aecfdbb377e6f46c6e468efbb6e28
ToppCellControl-Epithelial-ATI|Epithelial / Disease state, Lineage and Cell class

COL4A4 HEG1 AGRN UPK3B

4.11e-051874643a032432f780525f4f4c2a358897d9989b1ecae7
ToppCellwk_20-22-Endothelial-Lymph_endothelial-SCG3+_lymphatic_endothelial|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

AGRN UNC5B NUTM2G HR

4.11e-0518746455aad84b992412e487a32f4970620189a7380ba6
ToppCellfacs-Pancreas-Exocrine-24m-Mesenchymal-pancreatic_stellate_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ALPK3 FBLN2 FBN1 ADAMTS4

4.11e-0518746476c957b2976d38adb45e07bcf96c689442e1fc20
ToppCellTCGA-Breast-Primary_Tumor-Breast_Carcinoma-Infiltrating_Ductal_Carcinoma-6|TCGA-Breast / Sample_Type by Project: Shred V9

CORIN HEG1 FBN1 UNC5B

4.11e-05187464a96495803ba13fcfadd1d83b3cf5774f3fed0a20
ToppCellAT1-AT2_cells-Donor_01|World / lung cells shred on cell class, cell subclass, sample id

COL4A4 HEG1 AGRN UPK3B

4.20e-05188464be710bc957118cf426dd71c2d57e6f1b41c9a467
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

COL4A4 LAMA5 AGRN FBN3

4.20e-05188464eea652bab161f19148a883e7e3fe2523b36b3cea
ToppCelltumor_Lymph_Node_/_Brain-Fibroblasts-Undetermined|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass

FBLN2 PLPPR4 IGFBP7 PRSS12

4.20e-051884648231e635706a296db6b6da1029a33bbc1b52478e
ToppCelldroplet-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l17|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

COL4A4 FBLN2 FBN1 UNC5B

4.20e-051884646c6486cae9a8f2f8200598cb4bfd3fd513eb28a3
ToppCell5'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_I_pneumocyte-AT1-AT1_L.0.5.1.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

COL4A4 IGFBP7 RNF128 UPK3B

4.20e-05188464e9cef856a96a97afac5ecafe2ee91eff0d731e01
ToppCelldroplet-Kidney-nan-3m-Epithelial-Pecam____Kidney_cortex_artery_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HEG1 FBLN2 FBN1 HR

4.20e-05188464ec0e241de2c8310b4417b9d4e2420d7a1662f1c0
ToppCellEndothelial-A-SSc-ILD_01|World / lung cells shred on cell class, cell subclass, sample id

HEG1 FBLN2 IGFBP7 ADAMTS4

4.20e-051884640824d567356d360fd8e78e840c30529c139f98a1
ToppCellCOVID-19-Heart-Fib_1|COVID-19 / Disease (COVID-19 only), tissue and cell type

COL4A4 FBLN2 FBN1 IGFBP7

4.20e-05188464fe361215f4ba841aa5e1e581fb56f2f4d3ccd201
ToppCell10x3'2.3-week_17-19-Mesenchymal_osteo-stroma-osteochondral_precursor|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

FBN1 PLPPR4 IGFBP7 ADAMTS4

4.29e-051894641ff4f8da572bdc6356e9df9f41a7f62c81d4c570
ToppCellLPS_only-Endothelial-Endothelial-Artery|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

HEG1 FBLN2 FBN1 UNC5B

4.29e-05189464b028466fcd36fdeceec752e55a24286a1cd62ae4
ToppCellE17.5-Endothelial-large_vessel_endothelial_cell|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

HEG1 FBLN2 FBN1 UNC5B

4.29e-05189464360f09f46231a83f99d8fa0158b72a38068e1642
ToppCellPND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

HEG1 FBLN2 AGRN UNC5B

4.29e-051894649da012fdfa9a8d488cab710a463a1d70e89f990c
ToppCellLPS-IL1RA+antiTNF-Endothelial-Endothelial-Artery|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

HEG1 FBLN2 FBN1 UNC5B

4.29e-05189464c45734970036e6d28d5e3fe7c9458fae38a3f624
ToppCelldroplet-Limb_Muscle|droplet / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBLN2 FBN1 IGFBP7 ADAMTS4

4.38e-0519046406c2b13fa88abbcb8086f13b8d98a156e41e4198
ToppCellMatrixFB-Fibroblast-C|MatrixFB / shred on cell class and cell subclass (v4)

COL4A4 FBLN2 IGFBP7 UPK3B

4.38e-05190464d0106f7a21292f0b96ce4337ec3efbb1bd78dd0a
ToppCellFetal_29-31_weeks-Mesenchymal-matrix_fibroblast_2_cell-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

FBLN2 FBN1 IGFBP7 ADAMTS4

4.38e-051904640fea33f2dc1efa23aaa2da1c318482a52a313ff1
ToppCellLPS-IL1RA-Endothelial-Endothelial-Artery|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

HEG1 FBLN2 FBN1 UNC5B

4.38e-05190464aed65d584ca0c25f6a8313c66b421a6618af82ea
ToppCellmetastatic_Lymph_Node-Fibroblasts-Myofibroblasts|metastatic_Lymph_Node / Location, Cell class and cell subclass

LAMB4 FBLN2 FBN1 IGFBP7

4.47e-05191464aa43b472bc8362f79ae63f09f1ca764718bbf22c
ToppCellLAM-Epithelial-AT1|LAM / Condition, Lineage and Cell class

COL4A4 LAMA5 AGRN UPK3B

4.47e-0519146466875b2ec2c510489407f3e433a90cdf74a15094
ToppCell10x5'v1-week_12-13-Endothelial-stroma-tip_EC|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

LAMA5 FBN1 ADAMTS4 AGRN

4.47e-05191464cf1a67b7c0d5c0dc5d4d59faf9d9b1a3a1fb00e0
ToppCellPND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

HEG1 FBLN2 AGRN UNC5B

4.47e-051914643307dbccadb09c62b0e1c0235ec89bb294d748c3
ToppCell5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts-Peribronchial_fibroblasts_L.2.1.3.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FBLN2 FBN1 PLPPR4 IGFBP7

4.56e-05192464b9e4585bea280ca0ae159f0c6a2bf7b88a15a6e6
ToppCellfacs-Trachea-24m-Mesenchymal-fibroblast-fibroblast_of_trachea|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

HEG1 FBLN2 FBN1 IGFBP7

4.56e-051924647a2e79490e4f7058bb76b46c45b5df9f729e3146
Diseaseconnective tissue disease (implicated_via_orthology)

FBN1 FBN3

5.65e-063412DOID:65 (implicated_via_orthology)
DiseaseWeill-Marchesani syndrome

ADAMTS10 FBN1

5.65e-063412C0265313
DiseaseWeill-Marchesani Syndrome, Autosomal Dominant

ADAMTS10 FBN1

5.65e-063412C1869115
DiseaseWeill-Marchesani Syndrome, Autosomal Recessive

ADAMTS10 FBN1

5.65e-063412C1869114
DiseaseWeill-Marchesani syndrome (implicated_via_orthology)

ADAMTS10 FBN1

5.65e-063412DOID:0050475 (implicated_via_orthology)
DiseaseWeill-Marchesani syndrome

ADAMTS10 FBN1

1.13e-054412cv:C0265313
DiseaseWeill-Marchesani syndrome (is_implicated_in)

ADAMTS10 FBN1

1.13e-054412DOID:0050475 (is_implicated_in)
Diseasemitral valve prolapse (is_implicated_in)

TSHR FBN1

6.74e-059412DOID:988 (is_implicated_in)
Diseaseneutral ceramidase measurement

DRGX ASAH2

6.74e-059412EFO_0008247
Diseasebeta-aminoisobutyric acid measurement

AGXT2 FBN3

5.10e-0424412EFO_0010464
DiseaseMyasthenic Syndromes, Congenital

COLQ AGRN

5.10e-0424412C0751882
Diseasetransforming growth factor beta measurement

CUL9 HR

6.47e-0427412EFO_0004818
Diseaserefractive error

COL4A4 FBN1 IGFBP7 FBN3

1.07e-03326414MONDO_0004892

Protein segments in the cluster

PeptideGeneStartEntry
ELPGGTGCQPTMCPD

AGXT2

216

Q9BYV1
MASGQGPGPPRQECG

BAK1

1

Q16611
PTPPDACRGMLCGFG

AGRN

166

O00468
PGGVPCMDQGGCPLA

ALPK3

1046

Q96L96
PGEACAGMIGPPGPQ

COL4A4

396

P53420
KGNEGLCACEPGPMG

COL4A4

486

P53420
CPPGMRPLPGSGEGC

FBN3

2236

Q75N90
KPCGTLGLAPVGGMC

ADAMTS10

356

Q9H324
GPPGRCLCGPTMNVN

COLQ

286

Q9Y215
CQGDSGGPLMCERPG

PRSS12

821

P56730
NKCFPCPSGGCPQMG

PNLIP

311

P16233
CPIGGPSMCIAKGPG

ASAH2

376

Q9NR71
MVCPAGAGALEPGAP

HR

1071

O43593
FPAVAGGPTPGMGCQ

MBD3L5

146

A6NJ08
PPGGGKISCQFMLCP

FBLN2

101

P98095
FPAVAGGPTPGMGCQ

MBD3L2B

146

A0A1B0GVZ6
MSCPFGLGGLNCGNP

HEG1

1231

Q9ULI3
RPGTMGPQCRECAPG

LAMA5

2091

O15230
PMCARGEGEPCGGGG

IGFBP7

61

Q16270
FPAVAGGPTPGMGCQ

MBD3L3

146

A6NE82
CAMGPPGGGRNTVTP

DNAH1

2341

Q9P2D7
FGCPVGSPMNPGQLC

EEF1AKMT4-ECE2

866

P0DPD8
DGTPCGPAQACMGGR

ADAMTS4

491

O75173
PMACHEGGVGVGCIP

KLHL18

556

O94889
CVSGMGMGRGNPEPP

FBN1

2686

P35555
CMGDSGGPLVCEKPG

CORIN

981

Q9Y5Q5
GGPLCSCCVPDPMGL

DRGX

176

A6NNA5
PMECPPGGGACLCDP

LAMB4

1031

A4D0S4
PMGPCRGQADVPFCG

CUL9

1956

Q8IWT3
MPGCPCPGCGMAGPR

SLC39A13

1

Q96H72
FPAVAGGPTPGMGCQ

MBD3L4

146

A6NDZ8
FPAVAGGPTPGMGCQ

MBD3L2

146

Q8NHZ7
APGTLCGGVMCPPPL

NUTM2F

111

A1L443
APGTLCGGVMCPPPL

NUTM2G

111

Q5VZR2
STCGLQPCAGPVPGM

SSPOP

3076

A2VEC9
QMGGVLCPRPGCGAG

PRKN

326

O60260
MGPPPGAGVSCRGGC

RNF128

1

Q8TEB7
VVPPQQMGSGPCGSC

ZCCHC2

1001

Q9C0B9
GACPSCEGVQGPPMA

RECQL5

786

O94762
PGAVPGCNNSMPGGP

PLPPR4

506

Q7Z2D5
GMLCGGPQPGVQGPC

PRSS53

206

Q2L4Q9
PGGDGSPILPGMVCT

PRSS53

451

Q2L4Q9
PNGHPCSVGECGRPM

RNF213

4506

Q63HN8
CMAPPPQNGGRDCSG

UNC5B

326

Q8IZJ1
CAMSGRVCVGSPPGP

ULK2

761

Q8IYT8
MEPAGPCGFCPAGEV

ZNHIT2

1

Q9UHR6
PDQLPCGDPMAGSGG

UPK3B

166

Q9BT76
PRDLGGMGCSSPPCE

TSHR

16

P16473