Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	positive regulation of proteasomal protein catabolic process	DAB2IP TMTC3 CLU CSNK1D CSNK1E	1.90e-05	123	55	5	GO:1901800
GeneOntologyBiologicalProcess	positive regulation of protein catabolic process	DAB2IP VPS11 TMTC3 CLU CSNK1D CSNK1E	3.15e-05	228	55	6	GO:0045732
GeneOntologyBiologicalProcess	positive regulation of proteolysis involved in protein catabolic process	DAB2IP TMTC3 CLU CSNK1D CSNK1E	4.63e-05	148	55	5	GO:1903052
GeneOntologyBiologicalProcess	regulation of non-canonical Wnt signaling pathway	CSNK1D CSNK1E RNF213	8.42e-05	32	55	3	GO:2000050
GeneOntologyBiologicalProcess	positive regulation of catabolic process	DAB2IP VPS11 TMTC3 CLU PIK3CB CSNK1D CSNK1E PRKCD DHX9	9.01e-05	701	55	9	GO:0009896
GeneOntologyBiologicalProcess	positive regulation of amide metabolic process	CLU CSNK1E PRKCD	1.31e-04	37	55	3	GO:0034250
Domain	TEA	TEAD1 TEAD3	4.90e-05	4	54	2	PF01285
Domain	TEA_1	TEAD1 TEAD3	4.90e-05	4	54	2	PS00554
Domain	TEA/ATTS_dom	TEAD1 TEAD3	4.90e-05	4	54	2	IPR000818
Domain	TEF_metazoa	TEAD1 TEAD3	4.90e-05	4	54	2	IPR016361
Domain	TEA	TEAD1 TEAD3	4.90e-05	4	54	2	SM00426
Domain	TEA_2	TEAD1 TEAD3	4.90e-05	4	54	2	PS51088
Domain	Na_channel_asu	SCN1A SCN4A	3.64e-04	10	54	2	IPR001696
Domain	Na_trans_assoc	SCN1A SCN4A	3.64e-04	10	54	2	IPR010526
Domain	Na_trans_assoc	SCN1A SCN4A	3.64e-04	10	54	2	PF06512
Domain	ARM-type_fold	USP34 VPS11 PIK3CB MROH5 IPO11 XPO7	4.24e-04	339	54	6	IPR016024
Domain	IMPORTIN_B_NT	IPO11 XPO7	7.30e-04	14	54	2	PS50166
Domain	IBN_N	IPO11 XPO7	8.41e-04	15	54	2	PF03810
Domain	IBN_N	IPO11 XPO7	9.59e-04	16	54	2	SM00913
Domain	Importin-beta_N	IPO11 XPO7	1.09e-03	17	54	2	IPR001494
Domain	DSRM	DROSHA DHX9	1.36e-03	19	54	2	SM00358
Domain	dsrm	DROSHA DHX9	1.51e-03	20	54	2	PF00035
Domain	DS_RBD	DROSHA DHX9	1.66e-03	21	54	2	PS50137
Domain	-	DROSHA DHX9	2.75e-03	27	54	2	3.30.160.20
Domain	dsRBD_dom	DROSHA DHX9	2.96e-03	28	54	2	IPR014720
Domain	-	IFIH1 ATAD3B IFI44 RNF213 DHX9 RAD17 RIT2	5.45e-03	746	54	7	3.40.50.300
Domain	Olfact_rcpt	OR51B5 OR11L1 OR9Q1 OR2W1 OR4F15	5.46e-03	393	54	5	IPR000725
Domain	AAA+_ATPase	ATAD3B RNF213 RAD17	8.36e-03	144	54	3	IPR003593
Domain	AAA	ATAD3B RNF213 RAD17	8.36e-03	144	54	3	SM00382
Domain	-	KLHDC8A KLHL14	8.50e-03	48	54	2	2.120.10.80
Domain	-	DAB2IP PIK3CB PRKCD	9.00e-03	148	54	3	2.60.40.150
Domain	P-loop_NTPase	IFIH1 ATAD3B IFI44 RNF213 DHX9 RAD17 RIT2	1.07e-02	848	54	7	IPR027417
Domain	Kelch-typ_b-propeller	KLHDC8A KLHL14	1.10e-02	55	54	2	IPR015915
Pathway	PID_HEDGEHOG_GLI_PATHWAY	CSNK1D CSNK1E PRKCD FOXA2	8.92e-06	48	39	4	M219
Pathway	WP_ADHD_AND_AUTISM_ASD_PATHWAYS	DRD5 PIK3CB SCN1A SCN4A PRKCD DAGLA RIT2	5.74e-05	367	39	7	M48346
Pathway	REACTOME_RUNX3_REGULATES_YAP1_MEDIATED_TRANSCRIPTION	TEAD1 TEAD3	1.11e-04	6	39	2	MM15544
Pathway	REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION	TEAD1 TEAD3	2.07e-04	8	39	2	MM14816
Pathway	REACTOME_RUNX3_REGULATES_YAP1_MEDIATED_TRANSCRIPTION	TEAD1 TEAD3	2.07e-04	8	39	2	M27823
Pubmed	Human Rad17 C-terminal tail is phosphorylated by concerted action of CK1δ/ε and CK2 to promote interaction with the 9-1-1 complex.	CSNK1D CSNK1E RAD17	3.95e-09	3	56	3	31353086
Pubmed	Tead proteins activate the Foxa2 enhancer in the node in cooperation with a second factor.	TEAD1 TEAD3 FOXA2	1.38e-07	7	56	3	16207754
Pubmed	Casein kinase I delta/epsilon phosphorylates topoisomerase IIalpha at serine-1106 and modulates DNA cleavage activity.	CSNK1D CSNK1E	2.55e-06	2	56	2	19043076
Pubmed	CK1δ and CK1ε are components of human 40S subunit precursors required for cytoplasmic 40S maturation.	CSNK1D CSNK1E	2.55e-06	2	56	2	24424021
Pubmed	Regulation of casein kinase I epsilon and casein kinase I delta by an in vivo futile phosphorylation cycle.	CSNK1D CSNK1E	2.55e-06	2	56	2	9632646
Pubmed	Effects of altered expression and activity levels of CK1δ and ɛ on tumor growth and survival of colorectal cancer patients.	CSNK1D CSNK1E	2.55e-06	2	56	2	25404202
Pubmed	An evaluation of polymorphisms in casein kinase 1 delta and epsilon genes in major psychiatric disorders.	CSNK1D CSNK1E	2.55e-06	2	56	2	22981886
Pubmed	TEAD1 and TEAD3 Play Redundant Roles in the Regulation of Human Epidermal Proliferation.	TEAD1 TEAD3	2.55e-06	2	56	2	32142794
Pubmed	Targeting of the circadian clock via CK1δ/ε to improve glucose homeostasis in obesity.	CSNK1D CSNK1E	7.63e-06	3	56	2	27439882
Pubmed	CKIepsilon/delta-dependent phosphorylation is a temperature-insensitive, period-determining process in the mammalian circadian clock.	CSNK1D CSNK1E	7.63e-06	3	56	2	19805222
Pubmed	Centrosomal anchoring of the protein kinase CK1delta mediated by attachment to the large, coiled-coil scaffolding protein CG-NAP/AKAP450.	CSNK1D CSNK1E	7.63e-06	3	56	2	12270714
Pubmed	Lysophosphatidic acid-stimulated phosphorylation of PKD2 is mediated by PI3K p110β and PKCδ in myoblasts.	PIK3CB PRKCD	7.63e-06	3	56	2	23252604
Pubmed	Casein kinase 1 proteomics reveal prohibitin 2 function in molecular clock.	CSNK1D CSNK1E	7.63e-06	3	56	2	22384121
Pubmed	Nuclear phosphoinositide 3-kinase beta controls double-strand break DNA repair.	PIK3CB RAD17	7.63e-06	3	56	2	20368419
Pubmed	Gene expression levels of Casein kinase 1 (CK1) isoforms are correlated to adiponectin levels in adipose tissue of morbid obese patients and site-specific phosphorylation mediated by CK1 influences multimerization of adiponectin.	CSNK1D CSNK1E	7.63e-06	3	56	2	25724478
Pubmed	A comparative study of structural and conformational properties of casein kinase-1 isoforms: insights from molecular dynamics and principal component analysis.	CSNK1D CSNK1E	7.63e-06	3	56	2	25665722
Pubmed	CRISPR-mediated gene targeting of CK1δ/ε leads to enhanced understanding of their role in endocytosis via phosphoregulation of GAPVD1.	CSNK1D CSNK1E	7.63e-06	3	56	2	32321936
Pubmed	A novel family of TEA domain-containing transcription factors with distinct spatiotemporal expression patterns.	TEAD1 TEAD3	7.63e-06	3	56	2	8920920
Pubmed	Hepatic nuclear factor 3 and nuclear factor 1 regulate 5-aminolevulinate synthase gene expression and are involved in insulin repression.	ALAS1 FOXA2	7.63e-06	3	56	2	15123725
Pubmed	Casein kinase 1-epsilon or 1-delta required for Wnt-mediated intestinal stem cell maintenance.	CSNK1D CSNK1E	7.63e-06	3	56	2	28963394
Pubmed	Sequence analysis of the cDNA for the human casein kinase I delta (CSNK1D) gene and its chromosomal localization.	CSNK1D CSNK1E	7.63e-06	3	56	2	8786104
Pubmed	RNA helicase A is essential for normal gastrulation.	FOXA2 DHX9	7.63e-06	3	56	2	9811865
Pubmed	CK1δ/ε protein kinase primes the PER2 circadian phosphoswitch.	CSNK1D CSNK1E	1.52e-05	4	56	2	29784789
Pubmed	Involvement of casein kinase 1 epsilon/delta (Csnk1e/d) in the pathogenesis of familial Parkinson's disease caused by CHCHD2.	CSNK1D CSNK1E	1.52e-05	4	56	2	37578019
Pubmed	Casein kinase 1 delta functions at the centrosome to mediate Wnt-3a-dependent neurite outgrowth.	CSNK1D CSNK1E	1.52e-05	4	56	2	21422228
Pubmed	Physical and functional interactions between protein tyrosine phosphatase alpha, PI 3-kinase, and PKCdelta.	PIK3CB PRKCD	1.52e-05	4	56	2	11676480
Pubmed	The DNA-binding activity of mouse DNA methyltransferase 1 is regulated by phosphorylation with casein kinase 1delta/epsilon.	CSNK1D CSNK1E	1.52e-05	4	56	2	20192920
Pubmed	YAP/TEAD-mediated transcription controls cellular senescence.	TEAD1 TEAD3	1.52e-05	4	56	2	23576552
Pubmed	DHX9 pairs with IPS-1 to sense double-stranded RNA in myeloid dendritic cells.	IFIH1 DHX9	1.52e-05	4	56	2	21957149
Pubmed	Therapeutic Targeting of Casein Kinase 1δ/ε in an Alzheimer's Disease Mouse Model.	CSNK1D CSNK1E	1.52e-05	4	56	2	31334659
Pubmed	p53 is phosphorylated in vitro and in vivo by the delta and epsilon isoforms of casein kinase 1 and enhances the level of casein kinase 1 delta in response to topoisomerase-directed drugs.	CSNK1D CSNK1E	1.52e-05	4	56	2	9349507
Pubmed	Isolation and characterization of human casein kinase I epsilon (CKI), a novel member of the CKI gene family.	CSNK1D CSNK1E	1.52e-05	4	56	2	7797465
Pubmed	Localization of human transcription factor TEF-4 and TEF-5 (TEAD2, TEAD3) genes to chromosomes 19q13.3 and 6p21.2 using fluorescence in situ hybridization and radiation hybrid analysis.	TEAD1 TEAD3	1.52e-05	4	56	2	9889009
Pubmed	The TEA domain: a novel, highly conserved DNA-binding motif.	TEAD1 TEAD3	1.52e-05	4	56	2	2070413
Pubmed	A novel family of developmentally regulated mammalian transcription factors containing the TEA/ATTS DNA binding domain.	TEAD1 TEAD3	1.52e-05	4	56	2	8702974
Pubmed	Casein kinase 1 delta (CK1delta) regulates period length of the mouse suprachiasmatic circadian clock in vitro.	CSNK1D CSNK1E	1.52e-05	4	56	2	20421981
Pubmed	Tead transcription factors differentially regulate cortical development.	TEAD1 TEAD3	1.52e-05	4	56	2	32170161
Pubmed	Comparative expression analysis of TEADs and their splice variants in mouse embryonic stem cells.	TEAD1 TEAD3	1.52e-05	4	56	2	36516960
Pubmed	Involvement of casein kinase Iepsilon in cytokine-induced granulocytic differentiation.	CSNK1D CSNK1E	1.52e-05	4	56	2	15070676
Pubmed	Transcription factor mTEAD-2 is selectively expressed at the beginning of zygotic gene expression in the mouse.	TEAD1 TEAD3	1.52e-05	4	56	2	9169843
Pubmed	VGLL3 operates via TEAD1, TEAD3 and TEAD4 to influence myogenesis in skeletal muscle.	TEAD1 TEAD3	1.52e-05	4	56	2	31138678
Pubmed	Mechanosignalling via integrins directs fate decisions of pancreatic progenitors.	TEAD1 TEAD3 FOXA2	1.90e-05	32	56	3	30487608
Pubmed	Three brain sodium channel alpha-subunit genes are clustered on the proximal segment of mouse chromosome 2.	SCN1A NEB	2.54e-05	5	56	2	1679748
Pubmed	Phosphorylation of human enhancer filamentation 1 (HEF1) stimulates interaction with Polo-like kinase 1 leading to HEF1 localization to focal adhesions.	CSNK1D CSNK1E	2.54e-05	5	56	2	29191835
Pubmed	A new sodium channel alpha-subunit gene (Scn9a) from Schwann cells maps to the Scn1a, Scn2a, Scn3a cluster of mouse chromosome 2.	SCN1A NEB	2.54e-05	5	56	2	8812438
Pubmed	TEAD mediates YAP-dependent gene induction and growth control.	TEAD1 TEAD3	2.54e-05	5	56	2	18579750
Pubmed	TONDU (TDU), a novel human protein related to the product of vestigial (vg) gene of Drosophila melanogaster interacts with vertebrate TEF factors and substitutes for Vg function in wing formation.	TEAD1 TEAD3	2.54e-05	5	56	2	10518497
Pubmed	Control of intracellular dynamics of mammalian period proteins by casein kinase I epsilon (CKIepsilon) and CKIdelta in cultured cells.	CSNK1D CSNK1E	2.54e-05	5	56	2	11865049
Pubmed	Casein kinase 1 delta regulates the pace of the mammalian circadian clock.	CSNK1D CSNK1E	2.54e-05	5	56	2	19414593
Pubmed	Differential expression of the TEF family of transcription factors in the murine placenta and during differentiation of primary human trophoblasts in vitro.	TEAD1 TEAD3	2.54e-05	5	56	2	9671946
Pubmed	Nuclear entry of the circadian regulator mPER1 is controlled by mammalian casein kinase I epsilon.	CSNK1D CSNK1E	2.54e-05	5	56	2	10848614
Pubmed	Members of the TEAD family of transcription factors regulate the expression of Myf5 in ventral somitic compartments.	TEAD1 TEAD3	2.54e-05	5	56	2	21527258
Pubmed	Desynchrony between brain and peripheral clocks caused by CK1δ/ε disruption in GABA neurons does not lead to adverse metabolic outcomes.	CSNK1D CSNK1E	2.54e-05	5	56	2	29463694
Pubmed	TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition.	TEAD1 TEAD3	2.54e-05	5	56	2	19324877
Pubmed	Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP.	TEAD1 TEAD3	2.54e-05	5	56	2	22677547
Pubmed	Wnt-3a utilizes a novel low dose and rapid pathway that does not require casein kinase 1-mediated phosphorylation of Dvl to activate beta-catenin.	CSNK1D CSNK1E	2.54e-05	5	56	2	17027228
Pubmed	The CK1δ/ε-AES axis regulates tumorigenesis and metastasis in colorectal cancer.	CSNK1D CSNK1E	2.54e-05	5	56	2	33754069
Pubmed	Essential roles of CKIdelta and CKIepsilon in the mammalian circadian clock.	CSNK1D CSNK1E	2.54e-05	5	56	2	19948962
Pubmed	The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiation.	TEAD1 TEAD3	2.54e-05	5	56	2	20516196
Pubmed	Association of genetic variation in genes implicated in the beta-catenin destruction complex with risk of breast cancer.	CSNK1D CSNK1E	3.80e-05	6	56	2	18708403
Pubmed	A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF(beta-TRCP).	CSNK1D CSNK1E	3.80e-05	6	56	2	20048001
Pubmed	Phosphorylation at Ser244 by CK1 determines nuclear localization and substrate targeting of PKD2.	CSNK1D CSNK1E	3.80e-05	6	56	2	17962809
Pubmed	Casein kinase I phosphorylates and destabilizes the beta-catenin degradation complex.	CSNK1D CSNK1E	3.80e-05	6	56	2	11818547
Pubmed	Physiological role for casein kinase 1 in glutamatergic synaptic transmission.	CSNK1D CSNK1E	3.80e-05	6	56	2	16014721
Pubmed	Identification of a novel Wnt5a-CK1ɛ-Dvl2-Plk1-mediated primary cilia disassembly pathway.	CSNK1D CSNK1E	3.80e-05	6	56	2	22609948
Pubmed	Hippo Component TAZ Functions as a Co-repressor and Negatively Regulates ΔNp63 Transcription through TEA Domain (TEAD) Transcription Factor.	TEAD1 TEAD3	3.80e-05	6	56	2	25995450
Pubmed	TEAD/TEF transcription factors utilize the activation domain of YAP65, a Src/Yes-associated protein localized in the cytoplasm.	TEAD1 TEAD3	3.80e-05	6	56	2	11358867
Pubmed	High-throughput chemical screen identifies a novel potent modulator of cellular circadian rhythms and reveals CKIα as a clock regulatory kinase.	CSNK1D CSNK1E	3.80e-05	6	56	2	21179498
Pubmed	Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.	USP34 VPS11 SLC9A1 CLU MCFD2 XXYLT1 RNF213 IPO11 RAD17	4.62e-05	1061	56	9	33845483
Pubmed	Identification of minimal enhancer elements sufficient for Pax3 expression in neural crest and implication of Tead2 as a regulator of Pax3.	TEAD1 TEAD3	5.32e-05	7	56	2	14736747
Pubmed	SPOP-mediated ubiquitination and degradation of PDK1 suppresses AKT kinase activity and oncogenic functions.	CSNK1D CSNK1E	5.32e-05	7	56	2	34353330
Pubmed	Extensive variation between inbred mouse strains due to endogenous L1 retrotransposition.	DROSHA SCN1A	5.32e-05	7	56	2	18381897
Pubmed	Modeling of a human circadian mutation yields insights into clock regulation by PER2.	CSNK1D CSNK1E	5.32e-05	7	56	2	17218255
Pubmed	Axin-mediated CKI phosphorylation of beta-catenin at Ser 45: a molecular switch for the Wnt pathway.	CSNK1D CSNK1E	5.32e-05	7	56	2	12000790
Pubmed	Transcription enhancer factor 1 binds multiple muscle MEF2 and A/T-rich elements during fast-to-slow skeletal muscle fiber type transitions.	TEAD1 TEAD3	5.32e-05	7	56	2	12861002
Pubmed	SCFFBW7-mediated degradation of Brg1 suppresses gastric cancer metastasis.	CSNK1D CSNK1E	5.32e-05	7	56	2	30177679
Pubmed	Casein kinase 1 delta (CK1delta) interacts with the SNARE associated protein snapin.	CSNK1D CSNK1E	7.09e-05	8	56	2	17101137
Pubmed	The period of the circadian oscillator is primarily determined by the balance between casein kinase 1 and protein phosphatase 1.	CSNK1D CSNK1E	7.09e-05	8	56	2	21930935
Pubmed	Wnt-5a induces Dishevelled phosphorylation and dopaminergic differentiation via a CK1-dependent mechanism.	CSNK1D CSNK1E	7.09e-05	8	56	2	17244647
Pubmed	VEGF-mediated PI3K class IA and PKC signaling in cardiomyogenesis and vasculogenesis of mouse embryonic stem cells.	PIK3CB PRKCD	7.09e-05	8	56	2	21540297
Pubmed	Interaction of muscle and brain sodium channels with multiple members of the syntrophin family of dystrophin-associated proteins.	SCN1A SCN4A	7.09e-05	8	56	2	9412493
Pubmed	Dysbindin structural homologue CK1BP is an isoform-selective binding partner of human casein kinase-1.	CSNK1D CSNK1E	7.09e-05	8	56	2	16618118
Pubmed	SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis.	ATAD3B TMTC3 CLU TUBGCP3 IPO11 DHX9 XPO7	8.64e-05	657	56	7	36180527
Pubmed	International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels.	SCN1A SCN4A	9.10e-05	9	56	2	16382098
Pubmed	Hippo signaling regulates microprocessor and links cell-density-dependent miRNA biogenesis to cancer.	DROSHA TEAD1	9.10e-05	9	56	2	24581491
Pubmed	Expression pattern of neuronal and skeletal muscle voltage-gated Na+ channels in the developing mouse heart.	SCN1A SCN4A	9.10e-05	9	56	2	15746173
Pubmed	SDCBP promotes pancreatic cancer progression by preventing YAP1 from β-TrCP-mediated proteasomal degradation.	CSNK1D CSNK1E	9.10e-05	9	56	2	36828627
Pubmed	Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligase.	CSNK1D CSNK1E	9.10e-05	9	56	2	20708156
Pubmed	The SWI/SNF chromatin remodeling factor DPF3 regulates metastasis of ccRCC by modulating TGF-β signaling.	CSNK1D CSNK1E PYGM	9.78e-05	55	56	3	35945219
Pubmed	Phosphorylation of LRRK2 by casein kinase 1α regulates trans-Golgi clustering via differential interaction with ARHGEF7.	CSNK1D CSNK1E	1.14e-04	10	56	2	25500533
Pubmed	Tiam1 regulates the Wnt/Dvl/Rac1 signaling pathway and the differentiation of midbrain dopaminergic neurons.	CSNK1E FOXA2	1.14e-04	10	56	2	23109420
Pubmed	USP9X Deubiquitylates DVL2 to Regulate WNT Pathway Specification.	ATAD3B CSNK1D CSNK1E	1.40e-04	62	56	3	31340145
Pubmed	Protein recoding by ADAR1-mediated RNA editing is not essential for normal development and homeostasis.	IFIH1 IFI44	1.66e-04	12	56	2	28874170
Pubmed	Quantitative trait loci mapping of genes that influence the sensitivity and tolerance to ethanol-induced hypothermia in BXD recombinant inbred mice.	DRD5 SCN1A	1.66e-04	12	56	2	8169823
Pubmed	Centrosomal proteins CG-NAP and kendrin provide microtubule nucleation sites by anchoring gamma-tubulin ring complex.	CSNK1D CSNK1E TUBGCP3	1.68e-04	66	56	3	12221128
Pubmed	Expression pattern of transcriptional enhanced associate domain family member 1 (Tead1) in developing mouse molar tooth.	TEAD1 TEAD3	1.96e-04	13	56	2	33984529
Pubmed	Breaking constraint of mammalian axial formulae.	FOXA2 GDF11	1.96e-04	13	56	2	35017475
Pubmed	Nucleolar localization of DGCR8 and identification of eleven DGCR8-associated proteins.	DROSHA DHX9	1.96e-04	13	56	2	17765891
Pubmed	Clock genes may influence bipolar disorder susceptibility and dysfunctional circadian rhythm.	CSNK1D CSNK1E	1.96e-04	13	56	2	18228528
Pubmed	A molecular mechanism for circadian clock negative feedback.	CSNK1D CSNK1E	1.96e-04	13	56	2	21680841
GeneFamily	TEA domain transcription factors	TEAD1 TEAD3	2.31e-05	4	36	2	1183
GeneFamily	Sodium voltage-gated channel alpha subunits	SCN1A SCN4A	1.38e-04	9	36	2	1203
Drug	AC1MBZ1C	SLC9A1 DRD5 CALCR PIK3CB CSNK1D CSNK1E IFI44 PRKCD	3.93e-06	387	55	8	CID000003541
Drug	Piperacillin sodium salt [59703-84-3]; Down 200; 7.4uM; PC3; HT_HG-U133A	IFIH1 PIK3CB CSNK1E TEAD1 NEB DHX9	7.26e-06	194	55	6	4320_DN
Disease	syndromic X-linked intellectual disability Najm type (implicated_via_orthology)	CSNK1D CSNK1E	6.86e-05	7	54	2	DOID:0060807 (implicated_via_orthology)
Disease	mean reticulocyte volume	OR51B5 OR11L1 TMTC3 MCFD2 ZNF217 NEB IPO11 XPO7	9.65e-05	799	54	8	EFO_0010701
Disease	generalized epilepsy with febrile seizures plus 2 (implicated_via_orthology)	SCN1A SCN4A	1.47e-04	10	54	2	DOID:0111294 (implicated_via_orthology)
Disease	Dravet syndrome (implicated_via_orthology)	SCN1A SCN4A	1.47e-04	10	54	2	DOID:0080422 (implicated_via_orthology)
Disease	generalized epilepsy with febrile seizures plus (implicated_via_orthology)	SCN1A SCN4A	2.14e-04	12	54	2	DOID:0060170 (implicated_via_orthology)
Disease	Congenital myopathy (disorder)	SCN4A NEB	2.14e-04	12	54	2	C0270960
Disease	epilepsy (implicated_via_orthology)	TMTC3 SCN1A SCN4A DHX9	2.29e-04	163	54	4	DOID:1826 (implicated_via_orthology)
Disease	3-hydroxypropylmercapturic acid measurement	TRHDE USP34 PIK3CB XXYLT1 DAGLA	4.60e-04	352	54	5	EFO_0007014
Disease	Alzheimer's disease (is_marker_for)	DRD5 CLU CSNK1D CSNK1E	1.26e-03	257	54	4	DOID:10652 (is_marker_for)

Protein segments in the cluster

Peptide	Gene	Start	Entry
KPLHYNLMLTAFMEN	TRHDE	146	Q9UKU6
PVSCKILHFFHQYMM	CALCR	216	P30988
PQQYMAFLPHHIMVK	FBXO34	571	Q9NWN3
FQYHPNLPMHAVIME	CASP8AP2	1521	Q9UKL3
MSHMPGDLFNLYLHQ	RAD17	441	O75943
VFHKEIAAAYIHMMP	DRD5	401	P21918
PMEMYKEFAEHITNH	DAB2IP	341	Q5VWQ8
MDHQLHAPMYFLLSH	OR9Q1	51	Q8NGQ5
EMSPQELQLHYFKMH	MCFD2	66	Q8NI22
PHHTPQMMNYFLENL	ALAS1	576	P13196
NIDMPHRFKVHNYMS	PRKCD	226	Q05655
GYMMAKKHLEINPDH	HSP90AB3P	491	Q58FF7
FVEPHKNMEVMGFLH	IPO11	226	Q9UI26
FIMKEIMYHHLQPFL	FSIP2	5226	Q5CZC0
HNLHEPMYFFLAMLA	OR51B5	51	Q9H339
HYFVVMNPHLCLKMI	OR2W1	131	Q9Y3N9
HPQLHIESKIYKMMQ	CSNK1D	46	P48730
ILASEMVHFIHQMQY	TUBGCP3	706	Q96CW5
HSPMYMFLQHLSFLE	OR11L1	56	Q8NGX0
MDAHLHSPMYFLLAN	OR4F15	51	Q8NGB8
MYEMLVTQSHQPLLH	FHIP1A	121	Q05DH4
FNPMESIKLNHHDYI	IFI44	281	Q8TCB0
QKLLLDAMNYHLMPF	KLHL14	291	Q9P2G3
EYMFMQKYPHTHLVQ	GDF11	346	O95390
MHHVNMTPEFKELYI	IFIH1	926	Q9BYX4
MLHEHLPYVVMEGLN	DAGLA	646	Q9Y4D2
PHNHLQHYDMLKDMW	KLHDC8A	141	Q8IYD2
YEHQHSKMVPAYRMQ	CXorf1	81	O96002
NLIYTMQKHLEMNPH	DHX9	661	Q08211
FKMLQDMNSADPFHL	MROH5	91	Q6ZUA9
QPHKMDLKAYEQVMH	FOXA2	396	Q9Y261
MDALEKYNFPQMAHQ	DROSHA	1326	Q9NRR4
AMEHYPMTEHFDNVL	SCN4A	596	P35499
MTMQFISHQFPDYHD	RIT2	36	Q99578
KQVHNYPMFNLLMDI	PIK3CB	61	P42338
MPQHIMAILHYFEIV	SPTSSA	56	Q969W0
AMEHYPMTDHFNNVL	SCN1A	786	P35498
YDMSPIHQDKMNFIK	CCDC110	281	Q8TBZ0
FLYHMGQHSNKFMLV	ATAD3B	436	Q5T9A4
HAMFQPFLEMIHEAQ	CLU	241	P10909
PLSHLVMYMENFIEH	RNF213	766	Q63HN8
GKLFQQIMHYHMQHE	VPS11	686	Q9H270
PDLFKDIVNMLMHHD	PYGM	756	P11217
QVPMMHQKEMHRFLY	SERPINA11	241	Q86U17
PMCEYMINFIHKLKH	TEAD3	366	Q99594
PQLIAFYHKMEMKQA	SLC9A1	571	P19634
VMNVLEHFHKYMGIP	VPS53	181	Q5VIR6
ILLNHQMMHTGEKPY	ZNF841	691	Q6ZN19
HMNFIASLEPHVIMY	XPO7	901	Q9UIA9
YPEVLMMHQRLEHKY	ZNF217	721	O75362
MMHQRLEHKYNPDVH	ZNF217	726	O75362
FAPFHTHYPMLEDHM	TBCCD1	416	Q9NVR7
QHAMGMETYKHLFLE	USP34	1041	Q70CQ2
HLPEKYMMNSVLENF	TEAD1	371	P28347
ELKPMSYHLLNMIFH	TMTC3	86	Q6ZXV5
PVDYHLLMMFTKAEH	XXYLT1	96	Q8NBI6
HPQLHIESKFYKMMQ	CSNK1E	46	P49674
FMTPYIAHSQKMQDL	NEB	81	P20929