Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
HumanPheno	Wormian bones	FLNA NEK1 PRKG2 SETBP1	3.04e-05	61	16	4	HP:0002645
HumanPheno	Abnormality of the metacarpal bones	FLNA NEK1 PRKG2 TOPORS BRD4 SETBP1	4.13e-05	228	16	6	HP:0001163
HumanPheno	Abnormal metacarpal morphology	FLNA NEK1 PRKG2 TOPORS BRD4 SETBP1	4.13e-05	228	16	6	HP:0005916
HumanPheno	Synostosis involving bones of the upper limbs	FLNA NEK1 TOPORS BRD4 SETBP1	5.00e-05	140	16	5	HP:0100238
HumanPheno	Abnormal oral frenulum morphology	FLNA NEK1 TOPORS SETBP1	5.26e-05	70	16	4	HP:0000190
HumanPheno	Broad toe	FLNA NEK1 PRKG2 SETBP1	1.24e-04	87	16	4	HP:0001837
HumanPheno	Mesomelic leg shortening	FLNA NEK1	1.38e-04	6	16	2	HP:0004987
HumanPheno	Mesomelia	FLNA NEK1 PRKG2	1.57e-04	35	16	3	HP:0003027
HumanPheno	Short phalanx of the thumb	FLNA BRD4 SETBP1	1.85e-04	37	16	3	HP:0009660
Domain	-	PRKG2 CENPC KCNH3	1.47e-04	48	40	3	2.60.120.10
Domain	RmlC-like_jellyroll	PRKG2 CENPC KCNH3	1.76e-04	51	40	3	IPR014710
Domain	EPHD	MLLT6 MLLT10	1.01e-03	22	40	2	PS51805
Domain	Znf_C2H2-like	ZNF721 ZNF556 ZNF341 ZNF718 ZNF365 ZNF583 PRDM2	1.36e-03	796	40	7	IPR015880
Domain	Znf_C2H2	ZNF721 ZNF556 ZNF341 ZNF718 ZNF365 ZNF583 PRDM2	1.45e-03	805	40	7	IPR007087
Domain	ZnF_C2H2	ZNF721 ZNF556 ZNF341 ZNF718 ZNF365 ZNF583 PRDM2	1.48e-03	808	40	7	SM00355
Domain	CNMP_BINDING_1	PRKG2 KCNH3	2.13e-03	32	40	2	PS00888
Domain	CNMP_BINDING_2	PRKG2 KCNH3	2.13e-03	32	40	2	PS00889
Domain	cNMP	PRKG2 KCNH3	2.40e-03	34	40	2	SM00100
Domain	cNMP_binding	PRKG2 KCNH3	2.40e-03	34	40	2	PF00027
Domain	cNMP-bd_dom	PRKG2 KCNH3	2.54e-03	35	40	2	IPR000595
Domain	CNMP_BINDING_3	PRKG2 KCNH3	2.54e-03	35	40	2	PS50042
Domain	LAM_G_DOMAIN	FAT1 NRXN1	2.99e-03	38	40	2	PS50025
Domain	cNMP-bd-like	PRKG2 KCNH3	2.99e-03	38	40	2	IPR018490
Domain	-	ZNF721 ZNF556 ZNF341 ZNF718 ZNF583 PRDM2	3.02e-03	679	40	6	3.30.160.60
Domain	Laminin_G_2	FAT1 NRXN1	3.31e-03	40	40	2	PF02210
Domain	zf-C2H2	ZNF721 ZNF556 ZNF341 ZNF718 ZNF583 PRDM2	3.34e-03	693	40	6	PF00096
Domain	Znf_C2H2/integrase_DNA-bd	ZNF721 ZNF556 ZNF341 ZNF718 ZNF583 PRDM2	3.36e-03	694	40	6	IPR013087
Domain	LamG	FAT1 NRXN1	4.00e-03	44	40	2	SM00282
Domain	zf-C2H2_6	ZNF721 ZNF556 ZNF718 PRDM2	4.45e-03	314	40	4	PF13912
Domain	ZINC_FINGER_C2H2_2	ZNF721 ZNF556 ZNF341 ZNF718 ZNF583 PRDM2	5.76e-03	775	40	6	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF721 ZNF556 ZNF341 ZNF718 ZNF583 PRDM2	5.83e-03	777	40	6	PS00028
Domain	Laminin_G	FAT1 NRXN1	6.85e-03	58	40	2	IPR001791
Domain	Zinc_finger_PHD-type_CS	MLLT6 MLLT10	8.54e-03	65	40	2	IPR019786
Domain	PHD	MLLT6 MLLT10	1.12e-02	75	40	2	PF00628
Domain	Znf_PHD-finger	MLLT6 MLLT10	1.24e-02	79	40	2	IPR019787
Domain	-	MLLT6 MLLT10 TOPORS ZNF341	1.52e-02	449	40	4	3.30.40.10
Domain	PHD	MLLT6 MLLT10	1.56e-02	89	40	2	SM00249
Domain	Znf_PHD	MLLT6 MLLT10	1.62e-02	91	40	2	IPR001965
Domain	Znf_RING/FYVE/PHD	MLLT6 MLLT10 TOPORS ZNF341	1.64e-02	459	40	4	IPR013083
Domain	ZF_PHD_2	MLLT6 MLLT10	1.76e-02	95	40	2	PS50016
Domain	-	FAT1 NRXN1	1.76e-02	95	40	2	2.60.120.200
Pubmed	Joint influence of small-effect genetic variants on human longevity.	NRDE2 NRXN1 CDH4	1.10e-05	34	44	3	20834067
Pubmed	The PZP Domain of AF10 Senses Unmodified H3K27 to Regulate DOT1L-Mediated Methylation of H3K79.	MLLT6 MLLT10	1.56e-05	5	44	2	26439302
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	FLNA MLLT6 CENPC BRD4 INO80B BCORL1 NFRKB CAST	2.30e-05	954	44	8	36373674
Pubmed	Linking H3K79 trimethylation to Wnt signaling through a novel Dot1-containing complex (DotCom).	MLLT6 MLLT10	4.36e-05	8	44	2	20203130
Pubmed	Human transcription factor protein interaction networks.	ZNF66 MLLT6 ZNF721 FAT1 MLLT10 INO80B PRDM2 BCORL1 NFRKB	6.28e-05	1429	44	9	35140242
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	MLLT6 CENPC BRD4 PRDM2 BCORL1 NFRKB	1.12e-04	608	44	6	36089195
Pubmed	The mammalian INO80 chromatin remodeling complex is required for replication stress recovery.	INO80B NFRKB	1.63e-04	15	44	2	25016522
Pubmed	INO80 is required for oncogenic transcription and tumor growth in non-small cell lung cancer.	INO80B NFRKB	1.63e-04	15	44	2	27641337
Pubmed	Subunit organization of the human INO80 chromatin remodeling complex: an evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling.	INO80B NFRKB	1.63e-04	15	44	2	21303910
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	FLNA NEK1 BRD4 PRDM2 BCORL1	1.81e-04	418	44	5	34709266
Pubmed	The mINO80 chromatin remodeling complex is required for efficient telomere replication and maintenance of genome stability.	INO80B NFRKB	1.86e-04	16	44	2	23979016
Pubmed	Negative Regulation of p21Waf1/Cip1 by Human INO80 Chromatin Remodeling Complex Is Implicated in Cell Cycle Phase G2/M Arrest and Abnormal Chromosome Stability.	INO80B NFRKB	2.10e-04	17	44	2	26340092
Pubmed	Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.	NEK1 MLLT6 FAT1 CENPC BCORL1 TWF1	2.20e-04	689	44	6	36543142
Pubmed	The leukemogenic AF4-MLL fusion protein causes P-TEFb kinase activation and altered epigenetic signatures.	MLLT10 BRD4	2.36e-04	18	44	2	21030982
Pubmed	YY1 functions with INO80 to activate transcription.	INO80B NFRKB	2.36e-04	18	44	2	17721549
Pubmed	Molecular characterization of mutant mouse strains generated from the EUCOMM/KOMP-CSD ES cell resource.	KNG1 TWF1	2.64e-04	19	44	2	23912999
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	NRDE2 FLNA CCDC171 ZNF341 PRDM2 NFRKB CAST	3.92e-04	1084	44	7	11544199
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	FLNA TOPORS BRD4 PRDM2 NFRKB CAST	4.09e-04	774	44	6	15302935
Pubmed	Highly efficient purification of protein complexes from mammalian cells using a novel streptavidin-binding peptide and hexahistidine tandem tag system: application to Bruton's tyrosine kinase.	FLNA TWF1	4.24e-04	24	44	2	21080425
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	FLNA MLLT6 FAT1 MLLT10 ZNF341 BRD4 KCNH3	4.40e-04	1105	44	7	35748872
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	MLLT6 ZNF721 URI1 MLLT10 ZNF718 BRD4	5.13e-04	808	44	6	20412781
Pubmed	Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.	URI1 MLLT10 CENPC BRD4 NFRKB	5.50e-04	533	44	5	30554943
Pubmed	R2TP/Prefoldin-like component RUVBL1/RUVBL2 directly interacts with ZNHIT2 to regulate assembly of U5 small nuclear ribonucleoprotein.	URI1 BRD4 INO80B NFRKB	5.61e-04	300	44	4	28561026
Pubmed	Regulator of sex-limitation (Rsl) encodes a pair of KRAB zinc-finger genes that control sexually dimorphic liver gene expression.	ZNF721 ZNF718	6.21e-04	29	44	2	14563677
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	FLNA NEK1 BRD4 NFRKB CAST	6.29e-04	549	44	5	38280479
Pubmed	A genome-wide association study of behavioral disinhibition.	CACNA2D4 NRXN1	6.65e-04	30	44	2	23942779
Pubmed	Gene-smoking interactions identify several novel blood pressure loci in the Framingham Heart Study.	CACNA2D4 PRKG2	7.57e-04	32	44	2	25189868
Pubmed	A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene.	NEK1 URI1 CCDC171 BCORL1	8.10e-04	331	44	4	19490893
Pubmed	MYC Protein Interactome Profiling Reveals Functionally Distinct Regions that Cooperate to Drive Tumorigenesis.	CENPC BRD4 BCORL1 NFRKB	8.85e-04	339	44	4	30415952
Pubmed	Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia.	MLLT10 ZNF365 CCSER1	9.33e-04	151	44	3	17043677
Pubmed	The DNA sequence and comparative analysis of human chromosome 10.	TLX1NB MLLT10 ZNF365 APBB1IP	9.45e-04	345	44	4	15164054
Pubmed	WW domains provide a platform for the assembly of multiprotein networks.	URI1 BRD4 APBB1IP	9.87e-04	154	44	3	16055720
Pubmed	Characterization of the DOT1L network: implications of diverse roles for DOT1L.	MLLT6 MLLT10	1.24e-03	41	44	2	20431927
Interaction	TLE3 interactions	FLNA MLLT6 MLLT10 PRPF40B BRD4 BCORL1 NFRKB	1.34e-05	376	43	7	int:TLE3
GeneFamily	INO80 complex \|SRCAP complex	INO80B NFRKB	2.06e-04	15	26	2	595
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF721 ZNF556 ZNF341 ZNF718 ZNF365 ZNF583	4.47e-04	718	26	6	28
GeneFamily	PHD finger proteins	MLLT6 MLLT10	7.37e-03	90	26	2	88
Computational	Neighborhood of ERCC4	MLLT10 NRXN1 CDH4 KNG1 BRD4	6.13e-04	321	24	5	MORF_ERCC4
Computational	Genes in the cancer module 100.	FAT1 NRXN1 CDH4 FOLR2 BRD4 SETBP1	1.01e-03	544	24	6	MODULE_100
Computational	CNS genes.	FAT1 NRXN1 CDH4 FOLR2 BRD4 SETBP1	1.03e-03	546	24	6	MODULE_137
Computational	Genes in the cancer module 66.	FAT1 NRXN1 CDH4 FOLR2 BRD4 SETBP1	1.09e-03	552	24	6	MODULE_66
Disease	Semantic-Pragmatic Disorder	NRXN1 SETBP1	1.03e-04	11	41	2	C0454655
Disease	Auditory Processing Disorder, Central	NRXN1 SETBP1	1.03e-04	11	41	2	C0751257
Disease	Language Delay	NRXN1 SETBP1	1.03e-04	11	41	2	C0023012
Disease	Language Development Disorders	NRXN1 SETBP1	1.03e-04	11	41	2	C0023014
Disease	Speech Delay	NRXN1 SETBP1	1.03e-04	11	41	2	C0241210
Disease	sleep duration	NEK1 PRKG2 MLLT10 CDH4 CCSER1	1.41e-04	362	41	5	EFO_0005271
Disease	Multiple congenital anomalies	NRXN1 SETBP1	2.53e-04	17	41	2	C0000772
Disease	body weight	PRKG2 MLLT10 NRXN1 CCDC171 ZNF341 SETBP1 CAST CCSER1	2.95e-04	1261	41	8	EFO_0004338
Disease	body fat percentage	MLLT10 NRXN1 CCDC171 SETBP1 CAST	5.56e-04	488	41	5	EFO_0007800
Disease	nicotine use, generational effect measurement, illegal drug consumption, non-substance related disinhibited behaviour, alcohol drinking, alcohol dependence	CACNA2D4 NRXN1	7.47e-04	29	41	2	EFO_0004329, EFO_0005430, EFO_0005431, EFO_0005432, EFO_0008364, MONDO_0007079
Disease	smoking status measurement	MLLT10 NRXN1 CCDC171 KCNH3 SETBP1 NUCB2 CCSER1	9.93e-04	1160	41	7	EFO_0006527
Disease	pack-years measurement, systolic blood pressure	CACNA2D4 PRKG2	1.03e-03	34	41	2	EFO_0006335, EFO_0006526
Disease	Thyroid Gland Follicular Adenoma	BRD4 PRDM2	1.09e-03	35	41	2	C0151468
Disease	Thyroid Neoplasm	BRD4 PRDM2	1.22e-03	37	41	2	C0040136
Disease	schizophrenia, intelligence, self reported educational attainment	NEK1 NRXN1 PRPF40B ZNF365	1.34e-03	346	41	4	EFO_0004337, EFO_0004784, MONDO_0005090

Protein segments in the cluster

Peptide	Gene	Start	Entry
QQEKHPTHHERGQKK	MLLT6	226	P55198
LDKKGPQKHHFDQPS	CFAP97	356	Q9P2B7
KKKGHPGREQKKHHH	BRD4	726	O60885
TGEPQDKHKFPKHQK	CCDC171	841	Q6TFL3
KDKKPALGNHHDPAV	APBB1IP	491	Q7Z5R6
KEHNGVRGKHKHRKP	BCORL1	1171	Q5H9F3
HHKKGSEPKQEPTNQ	CCSER1	71	Q9C0I3
PLGHKKHKHRAKESQ	NKD1	396	Q969G9
HLSGHLQKQPKGKHK	KCNH3	176	Q9ULD8
KHQAEPKDKHLGPAT	FAT1	4211	Q14517
LKKHHEKRKHQPDHP	NFRKB	261	Q6P4R8
EKKPLQKHKQAHQTP	NEK1	331	Q96PY6
KGPHHGHIQIVKKDE	FBXO31	211	Q5XUX0
KHQHHKKTKRKHGPS	NRDE2	91	Q9H7Z3
HGKPRHQKDAKHPQM	NRXN1	521	Q9ULB1
KKKHENHPKVNHPGS	NUCB2	211	P80303
NHPKVNHPGSKDQLK	NUCB2	216	P80303
VKPKHSKHPDGHSGN	PRKG2	6	Q13237
KHKKKHHQEEDAGPT	INO80B	46	Q9C086
KTLANDKHSHKPHPV	CENPC	356	Q03188
DPEGKPKKTHIQDNH	FLNA	1586	P21333
FHHSHKHKKQDPLQP	CACNA2D4	996	Q7Z3S7
KHVSFKKPHQHSGEK	DEFB128	61	Q7Z7B8
SPHSGHKPQKGKKVV	CDH4	126	P55283
HHKTKPGPEDKLHDQ	FOLR2	36	P14207
EGPHLPNKKKHKKQA	CAST	16	P20810
KHKHGHGHGKHKNKG	KNG1	496	P01042
HSAPIKVHHNQTGKK	SLC17A5	86	Q9NRA2
HVEGKKPKAVAKNHS	PRDM2	1586	Q13029
FKAKHRIAHKPHSKP	URI1	171	O94763
DNHFGKSVHLQKPKP	MYH15	566	Q9Y2K3
HKQKHKKQPEPSPAL	MLLT10	241	P55197
NKQKHHPPHPSQTQK	TLX1NB	76	P0CAT3
HKLIPKGHEKRGHEN	ZNF718	96	Q3SXZ3
KKHMQTHKVWPPGHS	ZNF341	366	Q9BYN7
KAHFHPKGRNHLKKA	ZNF365	336	Q70YC5
LHLNKHEKIHTGKKP	ZNF721	446	Q8TF20
HKHARTHAKKKPVSG	ZNF556	331	Q9HAH1
LNKHQKTHAGEKPFP	ZNF840P	536	A6NDX5
KGKKHHHKRSHSPSG	PRPF40B	701	Q6NWY9
KKHKKHHGDNASRSP	TOPORS	891	Q9NS56
RHKKIHTGGKPHKCN	ZNF66	526	Q6ZN08
AAKHKAKHGVHLQGP	SETBP1	1106	Q9Y6X0
SFPTKEKAHKHEPQK	ZNF583	176	Q96ND8
QHAHKQSFAKPKGPA	TWF1	316	Q12792