Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	zinc ion binding	MMP27 PHC3 ZSWIM8 SEC24D TIMM9 ZCCHC2 MARCHF10 ZCCHC8 PHC1 PHC2	2.62e-06	891	36	10	GO:0008270
GeneOntologyMolecularFunction	transition metal ion binding	MMP27 PHC3 ZSWIM8 SEC24D TIMM9 ZCCHC2 MARCHF10 ZCCHC8 PHC1 PHC2	3.30e-05	1189	36	10	GO:0046914
GeneOntologyMolecularFunction	tau-protein kinase activity	TTBK2 SIK3	7.14e-04	22	36	2	GO:0050321
GeneOntologyMolecularFunction	microtubule plus-end binding	TTBK2 DST	7.14e-04	22	36	2	GO:0051010
GeneOntologyCellularComponent	PRC1 complex	PHC3 PHC1 PHC2	4.85e-06	19	37	3	GO:0035102
GeneOntologyCellularComponent	nuclear ubiquitin ligase complex	PHC3 PHC1 PHC2	8.89e-05	49	37	3	GO:0000152
GeneOntologyCellularComponent	PcG protein complex	PHC3 PHC1 PHC2	1.06e-04	52	37	3	GO:0031519
GeneOntologyCellularComponent	ubiquitin ligase complex	PHC3 ZSWIM8 ITCH PHC1 PHC2	3.68e-04	352	37	5	GO:0000151
GeneOntologyCellularComponent	nuclear body	MAML2 BMP2K ZCCHC8 PHC1 RFWD3 EPC1 YLPM1	9.07e-04	903	37	7	GO:0016604
Domain	Znf_FCS	PHC3 PHC1 PHC2	7.14e-08	5	37	3	IPR012313
Domain	ZF_FCS	PHC3 PHC1 PHC2	1.43e-07	6	37	3	PS51024
Domain	GAR	MACF1 DST	5.70e-05	6	37	2	PS51460
Domain	-	MACF1 DST	5.70e-05	6	37	2	3.30.920.20
Domain	-	MACF1 DST	5.70e-05	6	37	2	3.90.1290.10
Domain	GAS_dom	MACF1 DST	5.70e-05	6	37	2	IPR003108
Domain	GAS2	MACF1 DST	5.70e-05	6	37	2	PF02187
Domain	GAS2	MACF1 DST	5.70e-05	6	37	2	SM00243
Domain	Plectin_repeat	MACF1 DST	7.97e-05	7	37	2	IPR001101
Domain	Plectin	MACF1 DST	7.97e-05	7	37	2	PF00681
Domain	PLEC	MACF1 DST	7.97e-05	7	37	2	SM00250
Domain	SAM_1	PHC3 PHC1 PHC2	3.28e-04	68	37	3	PF00536
Domain	Kinase-like_dom	MACF1 TTBK2 SIK3 DST BMP2K MYO3B	6.28e-04	542	37	6	IPR011009
Domain	SAM	PHC3 PHC1 PHC2	6.99e-04	88	37	3	SM00454
Domain	SAM_DOMAIN	PHC3 PHC1 PHC2	8.74e-04	95	37	3	PS50105
Domain	SAM	PHC3 PHC1 PHC2	9.28e-04	97	37	3	IPR001660
Domain	Actinin_actin-bd_CS	MACF1 DST	9.41e-04	23	37	2	IPR001589
Domain	ACTININ_2	MACF1 DST	9.41e-04	23	37	2	PS00020
Domain	ACTININ_1	MACF1 DST	9.41e-04	23	37	2	PS00019
Domain	Spectrin	MACF1 DST	9.41e-04	23	37	2	PF00435
Domain	zf-CCHC	ZCCHC2 ZCCHC8	9.41e-04	23	37	2	PF00098
Domain	-	PHC3 PHC1 PHC2	1.20e-03	106	37	3	1.10.150.50
Domain	-	ZCCHC2 ZCCHC8	1.20e-03	26	37	2	4.10.60.10
Domain	Spectrin_repeat	MACF1 DST	1.50e-03	29	37	2	IPR002017
Domain	SAM/pointed	PHC3 PHC1 PHC2	1.59e-03	117	37	3	IPR013761
Domain	Spectrin/alpha-actinin	MACF1 DST	1.82e-03	32	37	2	IPR018159
Domain	SPEC	MACF1 DST	1.82e-03	32	37	2	SM00150
Domain	ZF_CCHC	ZCCHC2 ZCCHC8	2.18e-03	35	37	2	PS50158
Domain	WW	SAV1 ITCH	3.90e-03	47	37	2	PF00397
Domain	WW	SAV1 ITCH	4.07e-03	48	37	2	SM00456
Domain	WW_DOMAIN_2	SAV1 ITCH	4.58e-03	51	37	2	PS50020
Domain	WW_DOMAIN_1	SAV1 ITCH	4.58e-03	51	37	2	PS01159
Domain	WW_dom	SAV1 ITCH	4.76e-03	52	37	2	IPR001202
Domain	ZnF_C2HC	ZCCHC2 ZCCHC8	5.31e-03	55	37	2	SM00343
Domain	Znf_CCHC	ZCCHC2 ZCCHC8	5.31e-03	55	37	2	IPR001878
Domain	S_TKc	TTBK2 SIK3 BMP2K MYO3B	5.38e-03	359	37	4	SM00220
Domain	PROTEIN_KINASE_ST	TTBK2 SIK3 BMP2K MYO3B	5.53e-03	362	37	4	PS00108
Domain	Pkinase	TTBK2 SIK3 BMP2K MYO3B	6.62e-03	381	37	4	PF00069
Domain	CH	MACF1 DST	7.34e-03	65	37	2	SM00033
Domain	CH	MACF1 DST	8.47e-03	70	37	2	PF00307
Domain	-	MACF1 DST	8.71e-03	71	37	2	1.10.418.10
Domain	CH	MACF1 DST	9.19e-03	73	37	2	PS50021
Domain	CH-domain	MACF1 DST	9.68e-03	75	37	2	IPR001715
Domain	EF-hand_7	MACF1 DST	1.23e-02	85	37	2	PF13499
Domain	PROTEIN_KINASE_ATP	TTBK2 SIK3 BMP2K MYO3B	1.25e-02	459	37	4	PS00107
Pathway	REACTOME_SUMOYLATION_OF_DNA_METHYLATION_PROTEINS	PHC3 PHC1 PHC2	4.31e-06	16	29	3	M27403
Pathway	REACTOME_TRANSCRIPTIONAL_REGULATION_BY_E2F6	PHC3 PHC1 EPC1	1.75e-05	25	29	3	MM15546
Pathway	KEGG_MEDICUS_REFERENCE_DEUBIQUITINATION_OF_H2AK119	PHC3 PHC1 PHC2	1.97e-05	26	29	3	M47923
Pathway	REACTOME_RUNX1_INTERACTS_WITH_CO_FACTORS_WHOSE_PRECISE_EFFECT_ON_RUNX1_TARGETS_IS_NOT_KNOWN	PHC3 PHC1 PHC2	4.49e-05	34	29	3	MM15531
Pathway	REACTOME_TRANSCRIPTIONAL_REGULATION_BY_E2F6	PHC3 PHC1 EPC1	4.49e-05	34	29	3	M27826
Pathway	REACTOME_RUNX1_INTERACTS_WITH_CO_FACTORS_WHOSE_PRECISE_EFFECT_ON_RUNX1_TARGETS_IS_NOT_KNOWN	PHC3 PHC1 PHC2	5.80e-05	37	29	3	M27797
Pathway	REACTOME_SUMOYLATION_OF_TRANSCRIPTION_COFACTORS	PHC3 PHC1 PHC2	7.35e-05	40	29	3	MM15000
Pathway	KEGG_MEDICUS_REFERENCE_GENE_SILENCING_BY_METHYLATION_OF_H3K27_AND_UBIQUITINATION_OF_H2AK119	PHC3 PHC1 PHC2	7.35e-05	40	29	3	M47917
Pathway	REACTOME_SUMOYLATION_OF_TRANSCRIPTION_COFACTORS	PHC3 PHC1 PHC2	9.80e-05	44	29	3	M27295
Pathway	REACTOME_SUMOYLATION_OF_RNA_BINDING_PROTEINS	PHC3 PHC1 PHC2	1.19e-04	47	29	3	M27395
Pathway	REACTOME_SUMOYLATION_OF_RNA_BINDING_PROTEINS	PHC3 PHC1 PHC2	2.24e-04	58	29	3	MM15149
Pathway	REACTOME_TRANSCRIPTIONAL_REGULATION_BY_RUNX1	PHC3 ITCH PHC1 PHC2	2.56e-04	153	29	4	MM15522
Pathway	REACTOME_REGULATION_OF_PTEN_GENE_TRANSCRIPTION	PHC3 PHC1 PHC2	2.60e-04	61	29	3	M27811
Pathway	REACTOME_SUMOYLATION_OF_CHROMATIN_ORGANIZATION_PROTEINS	PHC3 PHC1 PHC2	3.14e-04	65	29	3	MM15147
Pathway	REACTOME_SUMOYLATION_OF_CHROMATIN_ORGANIZATION_PROTEINS	PHC3 PHC1 PHC2	4.07e-04	71	29	3	M27394
Pathway	REACTOME_SUMOYLATION_OF_DNA_DAMAGE_RESPONSE_AND_REPAIR_PROTEINS	PHC3 PHC1 PHC2	5.17e-04	77	29	3	M27226
Pathway	REACTOME_SIGNALING_BY_NOTCH1	MAML2 ITCH	6.13e-04	18	29	2	MM14775
Pathway	REACTOME_SUMOYLATION_OF_DNA_DAMAGE_RESPONSE_AND_REPAIR_PROTEINS	PHC3 PHC1 PHC2	6.67e-04	84	29	3	MM14929
Pathway	REACTOME_TRANSCRIPTIONAL_REGULATION_BY_RUNX1	PHC3 ITCH PHC1 PHC2	1.33e-03	237	29	4	M27786
Pathway	REACTOME_OXIDATIVE_STRESS_INDUCED_SENESCENCE	PHC3 PHC1 PHC2	2.10e-03	125	29	3	M27186
Pathway	REACTOME_PTEN_REGULATION	PHC3 PHC1 PHC2	2.84e-03	139	29	3	M27646
Pathway	REACTOME_SIGNALING_BY_NOTCH	MAML2 ITCH	2.89e-03	39	29	2	MM14604
Pathway	REACTOME_ER_TO_GOLGI_ANTEROGRADE_TRANSPORT	SEC24D TFG COG4	3.93e-03	156	29	3	M27097
Pathway	REACTOME_GENERIC_TRANSCRIPTION_PATHWAY	PHC3 MAML2 ITCH PHC1 PHC2 EPC1	4.14e-03	768	29	6	MM14851
Pubmed	Functional proteomics mapping of a human signaling pathway.	SOX5 MACF1 SEC24D DST LZTS2 ACBD3 ZCCHC8 YLPM1	2.07e-07	591	38	8	15231748
Pubmed	Several distinct polycomb complexes regulate and co-localize on the INK4a tumor suppressor locus.	PHC3 PHC1 PHC2	2.63e-07	12	38	3	19636380
Pubmed	The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans.	PHC3 PHC1 PHC2	6.67e-07	16	38	3	12167701
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	MACF1 ASTN2 ZSWIM8 ITCH DST CRIM1 ACBD3 ZCCHC8 COG4 YLPM1	8.41e-07	1285	38	10	35914814
Pubmed	Genetic interaction mapping in mammalian cells using CRISPR interference.	PHC3 PHC1 PHC2 EPC1	9.95e-07	69	38	4	28481362
Pubmed	Identification and characterisation of novel mammalian homologues of Drosophila polyhomeoticpermits new insights into relationships between members of the polyhomeotic family.	PHC3 PHC2	1.16e-06	2	38	2	12384788
Pubmed	Acf7 (MACF) is an actin and microtubule linker protein whose expression predominates in neural, muscle, and lung development.	MACF1 DST	1.16e-06	2	38	2	11002341
Pubmed	PRC1 and Suv39h specify parental asymmetry at constitutive heterochromatin in early mouse embryos.	PHC3 PHC1 PHC2	1.58e-06	21	38	3	18311137
Pubmed	SENP3 and USP7 regulate Polycomb-rixosome interactions and silencing functions.	PHC3 PHC1 PHC2	1.58e-06	21	38	3	37014752
Pubmed	Mammalian Polycomb Scmh1 mediates exclusion of Polycomb complexes from the XY body in the pachytene spermatocytes.	PHC1 PHC2	3.48e-06	3	38	2	17215307
Pubmed	Identification and characterization of interactions between the vertebrate polycomb-group protein BMI1 and human homologs of polyhomeotic.	PHC1 PHC2	3.48e-06	3	38	2	9121482
Pubmed	Expression of the mouse Macf2 gene during inner ear development.	MACF1 DST	3.48e-06	3	38	2	12399109
Pubmed	Transcription factor protein interactomes reveal genetic determinants in heart disease.	ZSWIM8 PHC1 RFWD3 PHC2 YLPM1 ARID3B	5.27e-06	411	38	6	35182466
Pubmed	Cloning and characterization of mouse ACF7, a novel member of the dystonin subfamily of actin binding proteins.	MACF1 DST	6.96e-06	4	38	2	8954775
Pubmed	RING1 is associated with the polycomb group protein complex and acts as a transcriptional repressor.	PHC1 PHC2	1.16e-05	5	38	2	9199346
Pubmed	A novel member of murine Polycomb-group proteins, Sex comb on midleg homolog protein, is highly conserved, and interacts with RAE28/mph1 in vitro.	MACF1 PHC1	1.16e-05	5	38	2	10653359
Pubmed	PCGF homologs, CBX proteins, and RYBP define functionally distinct PRC1 family complexes.	PHC3 PHC1 PHC2	1.25e-05	41	38	3	22325352
Pubmed	The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells.	MACF1 PHC3 ZCCHC8 PHC2 ARID3B	1.36e-05	282	38	5	23667531
Pubmed	MAPKAP kinase 3pK phosphorylates and regulates chromatin association of the polycomb group protein Bmi1.	PHC1 PHC2	2.43e-05	7	38	2	15563468
Pubmed	The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6→ Tbr2→ Tbr1.	PHC3 PHC1 PHC2 EPC1	2.62e-05	157	38	4	30186101
Pubmed	MAPKAP kinase MK2 maintains self-renewal capacity of haematopoietic stem cells.	PHC1 PHC2	3.24e-05	8	38	2	19369945
Pubmed	Proteomics analysis of Ring1B/Rnf2 interactors identifies a novel complex with the Fbxl10/Jhdm1B histone demethylase and the Bcl6 interacting corepressor.	PHC3 PHC1 PHC2	3.38e-05	57	38	3	17296600
Pubmed	Large-scale analysis of the regulatory architecture of the mouse genome with a transposon-associated sensor.	SOX5 MYOCD	4.16e-05	9	38	2	21423180
Pubmed	RYBP-PRC1 complexes mediate H2A ubiquitylation at polycomb target sites independently of PRC2 and H3K27me3.	PHC1 PHC2	4.16e-05	9	38	2	22325148
Pubmed	PRC1 and PRC2 are not required for targeting of H2A.Z to developmental genes in embryonic stem cells.	PHC1 PHC2 EPC1	5.02e-05	65	38	3	22496869
Pubmed	Mammalian polyhomeotic homologues Phc2 and Phc1 act in synergy to mediate polycomb repression of Hox genes.	PHC1 PHC2	6.35e-05	11	38	2	16024804
Pubmed	Involvement of the Polycomb-group gene Ring1B in the specification of the anterior-posterior axis in mice.	PHC1 PHC2	6.35e-05	11	38	2	12183370
Pubmed	The role of microtubule actin cross-linking factor 1 (MACF1) in the Wnt signaling pathway.	MACF1 DST	6.35e-05	11	38	2	16815997
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	PHC3 TIMM9 DST ZCCHC8 RFWD3 PHC2 EPC1 YLPM1	6.49e-05	1294	38	8	30804502
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	MACF1 ITCH SIK3 DST ARHGEF11 KCNT1 YLPM1	7.28e-05	963	38	7	28671696
Pubmed	Overexpression of Polycomb-group gene rae28 in cardiomyocytes does not complement abnormal cardiac morphogenesis in mice lacking rae28 but causes dilated cardiomyopathy.	PHC1 PHC2	9.00e-05	13	38	2	11950896
Pubmed	SOX5 controls the sequential generation of distinct corticofugal neuron subtypes.	SOX5 CRIM1	1.21e-04	15	38	2	18215621
Pubmed	Ubiquitin-specific proteases 7 and 11 modulate Polycomb regulation of the INK4a tumour suppressor.	PHC1 PHC2	1.21e-04	15	38	2	20601937
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	SAV1 TFG ACBD3 COG4 YLPM1 ARID3B	1.33e-04	733	38	6	34672954
Pubmed	Role of histone H2A ubiquitination in Polycomb silencing.	PHC1 PHC2	1.38e-04	16	38	2	15386022
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	MACF1 SIK3 DST ZCCHC8 COG4 PHC2 YLPM1	1.50e-04	1082	38	7	38697112
Pubmed	Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.	SOX5 SEC24D MYOCD LZTS2 MARCHF10 TFG PHC2 EPC1	1.63e-04	1477	38	8	31515488
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	MACF1 PHC3 DST LZTS2 ARHGEF11 BMP2K ZCCHC8 PHC2	1.78e-04	1497	38	8	31527615
Pubmed	A human MAP kinase interactome.	MACF1 SIK3 DST ARHGEF11 COG4	1.79e-04	486	38	5	20936779
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	MACF1 ZSWIM8 ITCH SIK3 LZTS2 ZCCHC8 EPC1	1.82e-04	1116	38	7	31753913
Pubmed	Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	MACF1 SEC24D DST	1.86e-04	101	38	3	9872452
Pubmed	Mammalian polycomb-mediated repression of Hox genes requires the essential spliceosomal protein Sf3b1.	PHC1 PHC2	1.96e-04	19	38	2	15741318
Pubmed	Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.	ZCCHC8 EPC1 YLPM1 ARID3B	2.07e-04	268	38	4	33640491
Pubmed	Analysis of interaction partners for eukaryotic translation elongation factor 1A M-domain by functional proteomics.	MACF1 DST	2.18e-04	20	38	2	21689717
Pubmed	Genomewide pharmacogenomic study of metabolic side effects to antipsychotic drugs.	SOX5 ASTN2	2.41e-04	21	38	2	20195266
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	MAML2 SIK3 DST LZTS2 KCNT1	2.65e-04	529	38	5	14621295
Pubmed	Interaction proteomics analysis of polycomb proteins defines distinct PRC1 complexes in mammalian cells.	PHC3 PHC1 PHC2	2.80e-04	116	38	3	21282530
Pubmed	A functional cellular framework for sex and estrous cycle-dependent gene expression and behavior.	SOX5 CRIM1	2.90e-04	23	38	2	35065713
Pubmed	Protein interactome reveals converging molecular pathways among autism disorders.	SOX5 ZSWIM8 LZTS2 ZCCHC2 PHC2	3.44e-04	560	38	5	21653829
Pubmed	Comparative interactome analysis of α-arrestin families in human and Drosophila.	ZSWIM8 ITCH ZCCHC2 ZCCHC8	3.73e-04	313	38	4	38270169
Pubmed	Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.	MACF1 DST ARHGEF11	3.91e-04	130	38	3	12421765
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	MACF1 ZSWIM8 LZTS2 ZCCHC2 ZCCHC8	4.30e-04	588	38	5	38580884
Pubmed	Tbr1 regulates regional and laminar identity of postmitotic neurons in developing neocortex.	SOX5 CRIM1	4.63e-04	29	38	2	20615956
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	MACF1 PHC3 DST ACBD3 ZCCHC8 YLPM1	4.89e-04	934	38	6	33916271
Pubmed	Developmental trajectories of thalamic progenitors revealed by single-cell transcriptome profiling and Shh perturbation.	SOX5 ASTN2	5.30e-04	31	38	2	36476860
Pubmed	A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal.	ZCCHC8 PHC1 ARID3B	5.49e-04	146	38	3	23892456
Pubmed	GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease.	MAML2 MARCHF10	6.01e-04	33	38	2	21658281
Pubmed	WW domains provide a platform for the assembly of multiprotein networks.	ITCH TFG YLPM1	6.41e-04	154	38	3	16055720
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	MACF1 ZSWIM8 DST ZCCHC8 YLPM1	6.91e-04	653	38	5	22586326
Pubmed	Large-scale identification of mammalian proteins localized to nuclear sub-compartments.	ITCH YLPM1	7.97e-04	38	38	2	11555636
Pubmed	Human transcription factor protein interaction networks.	SOX5 PHC3 TIMM9 DST EPC1 YLPM1 ARID3B	8.03e-04	1429	38	7	35140242
Pubmed	An Oct4-centered protein interaction network in embryonic stem cells.	ZCCHC8 PHC1 ARID3B	8.11e-04	167	38	3	20362541
Pubmed	Host-pathogen interactome mapping for HTLV-1 and -2 retroviruses.	SOX5 LZTS2	8.40e-04	39	38	2	22458338
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	ZSWIM8 SEC24D LZTS2 BMP2K ZCCHC8 RFWD3	8.50e-04	1038	38	6	26673895
Pubmed	Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.	SAV1 MAML2 SIK3 LZTS2 PHC1	8.79e-04	689	38	5	36543142
Pubmed	Identification and functional characterization of transcriptional activators in human cells.	SOX5 PHC3 EPC1 ARID3B	9.17e-04	398	38	4	35016035
Pubmed	The cell proliferation antigen Ki-67 organises heterochromatin.	DST ZCCHC8 YLPM1 ARID3B	1.02e-03	410	38	4	26949251
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	MACF1 TTBK2 PHC3 ZCCHC2 BMP2K COG4	1.06e-03	1084	38	6	11544199
Pubmed	A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.	ANKRD30A ZSWIM8 LZTS2 EPC1	1.07e-03	415	38	4	16385451
Interaction	KDM2B interactions	SOX5 PHC3 ACBD3 PHC1 PHC2	1.08e-05	161	37	5	int:KDM2B
Interaction	COMMD3-BMI1 interactions	PHC3 PHC1 PHC2	2.47e-05	31	37	3	int:COMMD3-BMI1
Interaction	PCGF1 interactions	SOX5 PHC3 PHC1 PHC2 YLPM1	3.72e-05	208	37	5	int:PCGF1
Interaction	CBX7 interactions	PHC3 PHC1 PHC2	8.19e-05	46	37	3	int:CBX7
Interaction	CBX8 interactions	SOX5 PHC3 LZTS2 PHC1 PHC2	8.73e-05	249	37	5	int:CBX8
Interaction	R3HDM2 interactions	ZSWIM8 LZTS2 ZCCHC2 TFG	8.98e-05	129	37	4	int:R3HDM2
Interaction	GBA1 interactions	ITCH BMP2K HCCS ZCCHC8	1.01e-04	133	37	4	int:GBA1
Interaction	SRF interactions	PHC3 MYOCD EPC1 ARID3B	1.20e-04	139	37	4	int:SRF
Interaction	ARRDC2 interactions	ZSWIM8 ITCH ZCCHC2	1.32e-04	54	37	3	int:ARRDC2
Interaction	SCMH1 interactions	PHC3 PHC1 PHC2	1.32e-04	54	37	3	int:SCMH1
Interaction	BMI1 interactions	PHC3 CFAP141 DST ZCCHC8 PHC1 PHC2 YLPM1	1.70e-04	659	37	7	int:BMI1
Interaction	SCML1 interactions	PHC3 PHC1 PHC2	1.73e-04	59	37	3	int:SCML1
Interaction	PHC2 interactions	PHC3 PHC1 PHC2 EPC1	1.74e-04	153	37	4	int:PHC2
Interaction	BCOR interactions	SOX5 PHC3 PHC1 PHC2 ARID3B	2.15e-04	302	37	5	int:BCOR
Interaction	C11orf52 interactions	MACF1 ITCH DST LZTS2 ACBD3	2.46e-04	311	37	5	int:C11orf52
Interaction	NRIP1 interactions	MACF1 DST ACBD3 COG4	2.60e-04	170	37	4	int:NRIP1
GeneFamily	EF-hand domain containing\|Plakins	MACF1 DST	4.71e-05	8	24	2	939
GeneFamily	Sterile alpha motif domain containing	PHC3 PHC1 PHC2	2.09e-04	88	24	3	760
GeneFamily	Zinc fingers CCHC-type\|RNA binding motif containing	ZCCHC2 ZCCHC8	4.97e-04	25	24	2	74
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_DN	MACF1 SEC24D ITCH SIK3 DST CRIM1 BMP2K ACBD3	2.08e-05	856	37	8	M4500
Coexpression	LAKE_ADULT_KIDNEY_C24_ENDOTHELIAL_CELLS_AEA_AND_DVR	SOX5 MACF1 DST CRIM1	6.19e-05	152	37	4	M39243
Coexpression	LAKE_ADULT_KIDNEY_C27_VASCULAR_SMOOTH_MUSCLE_CELLS_AND_PERICYTES	SOX5 SIK3 DST CRIM1	6.67e-05	155	37	4	M39246
Coexpression	BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_UP	TTBK2 SEC24D ITCH SIK3 DST ACBD3 ARID3B	1.32e-04	822	37	7	M6782
Coexpression	GSE13411_NAIVE_BCELL_VS_PLASMA_CELL_UP	SAV1 MACF1 ZCCHC2 PHC1	1.65e-04	196	37	4	M3243
Coexpression	GSE22886_NAIVE_TCELL_VS_NKCELL_DN	MACF1 ZSWIM8 ITCH CRIM1	1.72e-04	198	37	4	M4415
Coexpression	GSE40666_UNTREATED_VS_IFNA_STIM_STAT4_KO_EFFECTOR_CD8_TCELL_90MIN_DN	SAV1 PHC3 MAML2 BMP2K	1.75e-04	199	37	4	M9236
Coexpression	GSE37416_0H_VS_24H_F_TULARENSIS_LVS_NEUTROPHIL_DN	SAV1 ITCH LZTS2 TFG	1.75e-04	199	37	4	M5350
Coexpression	GSE39820_CTRL_VS_TGFBETA1_IL6_IL23A_CD4_TCELL_UP	PHC3 SIK3 ZCCHC2 CRIM1	1.75e-04	199	37	4	M5607
Coexpression	GSE14308_TH17_VS_INDUCED_TREG_UP	TTBK2 ITCH SIK3 CCDC39	1.78e-04	200	37	4	M3385
Coexpression	GSE22886_NAIVE_CD8_TCELL_VS_DC_DN	CRIM1 ARHGEF11 TFG HCCS	1.78e-04	200	37	4	M4492
ToppCell	droplet-Kidney-KIDNEY-30m-Lymphocytic-Epcam____proximal_tube_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MAML2 MARCHF10 BMP2K YLPM1	8.83e-06	158	37	4	1d78578dc1f8ba43dacdccae1082c0b9d749f64d
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ASTN2 DST MARCHF10 MYO3B	9.75e-06	162	37	4	373513f9d0e5007b2e10a8b78d4909dcce9e3b62
ToppCell	facs-Brain_Myeloid-Cerebellum-3m-Myeloid-nan\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MACF1 MAML2 DST BMP2K	1.26e-05	173	37	4	869da6a65d1b9b7529c666ec44e3c8ddec2ea408
ToppCell	facs-Brain_Myeloid-Cerebellum-3m-Myeloid\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MACF1 MAML2 DST BMP2K	1.26e-05	173	37	4	0672bd8a4a9d18af343d01f09253fb3388896c10
ToppCell	facs-Brain_Myeloid-Cerebellum-3m\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MACF1 MAML2 DST BMP2K	1.26e-05	173	37	4	870e091ec30be01a900e1cb8b9ef1880e3b7b50d
ToppCell	3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts-Myofibroblasts_L.2.3.2.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MACF1 MAML2 DST CRIM1	1.32e-05	175	37	4	1799a7be623dc3bf53ba580a7c47d2619969d708
ToppCell	facs-Brain_Myeloid-Cerebellum-3m-Myeloid-microglial_cell\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MACF1 MAML2 DST BMP2K	1.32e-05	175	37	4	1ea6cf9da26601646f57fa14d558a5e9e1f0b345
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ASTN2 DST MARCHF10 MYO3B	1.54e-05	182	37	4	a8cc56f32efe180e8fb5d69dbe606a794b3db700
ToppCell	COVID-19-Fibroblasts-Airway_smooth_muscle\|COVID-19 / group, cell type (main and fine annotations)	SOX5 MYOCD DST CRIM1	1.71e-05	187	37	4	464a0c3b92b778911b5f9cd73642e09e3472063a
ToppCell	renal_medulla_nuclei\|World / Celltypes from Cells and Nuclei per compartment and clinical group	ASTN2 MAML2 SIK3 MYO3B	1.79e-05	189	37	4	830d9cd0dd706bce22eb2416f07b2c31c870a05a
ToppCell	Mesenchymal-vascular_smooth_muscle_cell\|World / Lineage, Cell type, age group and donor	SOX5 MYOCD CRIM1 KCNT1	1.86e-05	191	37	4	fd89fbc62aa1c73e0f659991e3bd726a0c97bd68
ToppCell	356C-Fibroblasts-Fibroblast-G-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	MACF1 DST CRIM1	3.14e-04	160	37	3	0293b244c063a62819690bf22bbc2681f8d15252
ToppCell	356C-Fibroblasts-Fibroblast-G\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	MACF1 DST CRIM1	3.14e-04	160	37	3	3eaae86fa08f7651021316f8e5811bf48055591e
ToppCell	Fetal_29-31_weeks-Mesenchymal-vascular_smooth_muscle_cell-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	MYOCD CRIM1 KCNT1	3.31e-04	163	37	3	51dee6c21cbeca4e17d1cc386e203f0c403089e8
ToppCell	facs-Marrow-KLS-24m-Lymphocytic-naive_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZSWIM8 CFAP141 MYO3B	3.31e-04	163	37	3	b83a35c4426d66b5734a98fa6c72b345fe462030
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_B\|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)	SAV1 BMP2K TFG	3.31e-04	163	37	3	6bed27d2f67a430a847da5eb47878d14b4949c45
ToppCell	facs-Marrow-KLS-24m-Lymphocytic-naive_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZSWIM8 CFAP141 MYO3B	3.31e-04	163	37	3	c20ca9b6b4170ebcb0e66eef3e5d8ebff22b1a91
ToppCell	facs-Marrow-KLS-24m-Lymphocytic\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZSWIM8 CFAP141 MYO3B	3.37e-04	164	37	3	d2b5f51af7fcffddebe997ee302bacbd85d76852
ToppCell	Ciliated_cells-A-SSc-ILD_02\|World / lung cells shred on cell class, cell subclass, sample id	CFAP141 MARCHF10 CCDC39	3.56e-04	167	37	3	edb722ee9b6ccd00fb038f702be8664020932659
ToppCell	15-Distal-Epithelial-Multiciliated_cell\|Distal / Age, Tissue, Lineage and Cell class	CFAP141 MARCHF10 CCDC39	3.68e-04	169	37	3	425d89ab69e9f9eb3df84056676423e390cc6ab1
ToppCell	wk_08-11-Epithelial-Proximal_epithelial-Deuterosomal\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	CFAP141 MARCHF10 CCDC39	3.88e-04	172	37	3	08ad76412c9cc3504141797b44b88478ced87476
ToppCell	COVID-19-Heart-VSMC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	SOX5 MYOCD KCNT1	4.08e-04	175	37	3	1125f0d3a5b2388fa77a820dea0288e824d84a82
ToppCell	Ciliated_cells-A-IPF_01\|World / lung cells shred on cell class, cell subclass, sample id	CFAP141 MARCHF10 CCDC39	4.29e-04	178	37	3	255473ee6df8a13079fb3bb61038162a40cb4c2c
ToppCell	droplet-Marrow-nan-3m-Hematologic-hematopoietic_precursor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MACF1 LZTS2 CRIM1	4.29e-04	178	37	3	8aef208b6351143562c87715bb11628880abce94
ToppCell	NS-moderate-d_16-33-Epithelial-Ionocyte\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	ANKRD30A DST MARCHF10	4.43e-04	180	37	3	8af8b4af2dc72223ac71fc027e0d4280c5dd81f8
ToppCell	5'-Airway_Nasal-Epithelial-Neuro-endocrine/ionocytic-ionocyte-Ionocyte\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ANKRD30A DST MARCHF10	4.50e-04	181	37	3	2b53a65ca5616a7b9f64232c3e0b7212d1e2f063
ToppCell	368C-Epithelial_cells-Epithelial-F_(Ciliated)-\|368C / Donor, Lineage, Cell class and subclass (all cells)	CFAP141 MARCHF10 CCDC39	4.50e-04	181	37	3	5a4574f1bfd0b4ca78da7effda43420857e17296
ToppCell	368C-Epithelial_cells-Epithelial-F_(Ciliated)\|368C / Donor, Lineage, Cell class and subclass (all cells)	CFAP141 MARCHF10 CCDC39	4.50e-04	181	37	3	a4e891603645f694687e68e585744ddc1a3c8697
ToppCell	5'-Airway_Nasal-Epithelial-Neuro-endocrine/ionocytic-ionocyte\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ANKRD30A DST MARCHF10	4.50e-04	181	37	3	6aef84616e8d2faf54b7e9e6cd02f33c3066dabc
ToppCell	5'-Airway_Nasal-Epithelial-Neuro-endocrine/ionocytic-ionocyte-Ionocyte-Ionocyte_L.0.7.0.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ANKRD30A DST MARCHF10	4.50e-04	181	37	3	40df0afcb6848202da54670e84f22d7c3a515d01
ToppCell	facs-Marrow-T-cells-3m-Hematologic\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEC24D MAML2 HCCS	4.50e-04	181	37	3	57f0cc749ae8b6a3d77e2af31f9a6e4739c57049
ToppCell	5'-Airway_Nasal-Epithelial-Neuro-endocrine/ionocytic\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ANKRD30A DST MARCHF10	4.50e-04	181	37	3	40d3829ae4aaf81e8616c3499ff8933137fc1cc4
ToppCell	facs-Marrow-T-cells-3m-Hematologic-hematopoietic_stem_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEC24D MAML2 HCCS	4.50e-04	181	37	3	d01b35cc2fc57991a35be6a06cb7351fbabd9a11
ToppCell	343B-Lymphocytic-CD4_T-cell-Treg_cell_1\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	ZCCHC8 COG4 YLPM1	4.65e-04	183	37	3	807d64deaf4e50dccf6f831f88578a6d903c1421
ToppCell	368C-Lymphocytic-CD4_T-cell-Treg_cell_2\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	SEC24D ACBD3 YLPM1	4.65e-04	183	37	3	310ad42b2b5d8ddd01d3a12db338f80ac1f5d08e
ToppCell	5'-GW_trimst-2-SmallIntestine-Hematopoietic-Myeloid-Mast_cell\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ASTN2 PHC3 BMP2K	4.72e-04	184	37	3	16ba6822570b1017b8f24d9439b4fbdaaeecf7aa
ToppCell	NS-moderate-d_07-13-Epithelial-Ciliated\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	CFAP141 MARCHF10 CCDC39	4.87e-04	186	37	3	85787ff207f109ec7e3c0f729ba9bda739c2fdc9
ToppCell	18-Distal-Epithelial-Multiciliated_precursor\|Distal / Age, Tissue, Lineage and Cell class	CFAP141 MARCHF10 CCDC39	4.87e-04	186	37	3	58ab1360a1730655a5939295ba05997ac4a2d14e
ToppCell	E16.5-samps-Mesenchymal-Myofibroblast\|E16.5-samps / Age Group, Lineage, Cell class and subclass	SOX5 MYOCD DST	4.87e-04	186	37	3	e044b3428b7eacfdc72d0f57cdabaa1de04c74cd
ToppCell	18-Distal-Epithelial-Multiciliated_cell\|Distal / Age, Tissue, Lineage and Cell class	CFAP141 MARCHF10 CCDC39	4.95e-04	187	37	3	8d7fa6b2950898e7f283401808378ba2a41b9651
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ASTN2 DST MYO3B	4.95e-04	187	37	3	87b3d0478693d4c54ff06b74e5903036b9c1ee6a
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ASTN2 DST MYO3B	4.95e-04	187	37	3	77886f99c229610abd28c4c370d2c7d1536c9782
ToppCell	367C-Lymphocytic-NK_cells-NK_cell_B0\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	MAML2 BMP2K HCCS	4.95e-04	187	37	3	816d37a70f7ec382a268fe828b3dfe737a36a4bf
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ASTN2 DST MYO3B	4.95e-04	187	37	3	42a1267bfc27b4460b8409ada580a87c4385841c
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SOX5 MYOCD KCNT1	4.95e-04	187	37	3	958402fcc78f4c7a7d13d659d776f3817137975f
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ASTN2 DST MYO3B	4.95e-04	187	37	3	64afdea159f5e67a1e5cea35ce898aae6e80aea5
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SOX5 MYOCD KCNT1	4.95e-04	187	37	3	48bfdb3504c3fefe5db3abac4b790c369680ab4e
ToppCell	LA-13._Vascular_Smooth_Muscle\|LA / Chamber and Cluster_Paper	MACF1 MYOCD CRIM1	5.02e-04	188	37	3	34e1b074a3995aa46ab194eb45115d76d1a5514d
ToppCell	LA-13._Vascular_Smooth_Muscle\|World / Chamber and Cluster_Paper	MACF1 MYOCD CRIM1	5.10e-04	189	37	3	6b3e88751b95fc2173f2c3d5061ed632d0c5f01c
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SOX5 MYOCD KCNT1	5.10e-04	189	37	3	fac5c291a9a87418bb0878c3d624829bdbf1f428
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SOX5 MYOCD CRIM1	5.10e-04	189	37	3	2cfb4d12f75678d1619f4743838a0e954bd57761
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SOX5 MYOCD CRIM1	5.10e-04	189	37	3	127ad2ba3e794df8cce2eee3e4171bccb5aad51b
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SOX5 MYOCD CRIM1	5.10e-04	189	37	3	7ab1cfc1657277858339f7258a0c4ae9cb42fdf8
ToppCell	Fetal_29-31_weeks-Mesenchymal-vascular_smooth_muscle_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	SOX5 MYOCD CRIM1	5.18e-04	190	37	3	d6b3a92119b210974a32af3fe9875d60eb02761e
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SOX5 DST PHC2	5.26e-04	191	37	3	cb0aee740b08f7d5fdd2717ecf7429043b277ae7
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SOX5 DST PHC2	5.26e-04	191	37	3	c54c420a94dc749ebc67fc64c5614663f4b9798d
ToppCell	COVID-19-Heart-Fib_+_EC_+_Pericyte\|Heart / Disease (COVID-19 only), tissue and cell type	SOX5 SEC24D MAML2	5.34e-04	192	37	3	60b1312e84f6d6448365a952469c506c00b5fe93
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SOX5 MYOCD CRIM1	5.34e-04	192	37	3	992d08092edbc68c47b945deb8708379738c239a
ToppCell	10x5'-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8\|lymph-node_spleen / Manually curated celltypes from each tissue	MACF1 MAML2 SIK3	5.34e-04	192	37	3	47646d7e4990be85072987f92bf18d52f8da752e
ToppCell	renal_cortex_nuclei\|World / Celltypes from Cells and Nuclei per compartment and clinical group	MACF1 MAML2 SIK3	5.34e-04	192	37	3	e8cc4d08fcfceeab75a02558817e4ccd7dbafe3a
ToppCell	facs-Brain_Myeloid-Hippocampus-3m-Myeloid\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MACF1 DST BMP2K	5.42e-04	193	37	3	06b65110db974f4ef90d3511ff34428976a52c9c
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro1_(4)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	MACF1 MAML2 DST	5.42e-04	193	37	3	9f69edc97b868d23998abc98928a2e89a885ef8a
ToppCell	Control-Stromal-Myofibroblast\|Stromal / Disease state, Lineage and Cell class	MACF1 DST CRIM1	5.42e-04	193	37	3	5896242f713ae5fd1a4ebb63827f15d7279dced2
ToppCell	facs-Brain_Myeloid-Hippocampus-3m-Myeloid-microglial_cell\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MACF1 DST BMP2K	5.42e-04	193	37	3	9c16032bc03df8760ae199e8f19fdafa4c3f1827
ToppCell	facs-Brain_Myeloid-Hippocampus-3m\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MACF1 DST BMP2K	5.42e-04	193	37	3	a4f91bca5eaa985982d33a528f7566ffde154d47
ToppCell	facs-Brain_Myeloid-Hippocampus-3m-Myeloid-nan\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MACF1 DST BMP2K	5.42e-04	193	37	3	b39d7feaac4ff8f7409cd3d15e8f3c6391367275
ToppCell	368C-Fibroblasts-Fibroblast-G-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	MACF1 DST CRIM1	5.51e-04	194	37	3	d9eec28fa7b255c0ec023276dd955f1e276e7159
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B-B_cell-B_c02-MS4A1-CD27\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	SOX5 SIK3 BMP2K	5.51e-04	194	37	3	d852aebf7a763b9a776c4570711f0c759f591910
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SOX5 MYOCD CRIM1	5.51e-04	194	37	3	5c3b2b05d1e4f146551fe4c920263d8e6ca34de3
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature5_(6)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	SOX5 MACF1 DST	5.51e-04	194	37	3	b1bb0f846d2865efdd9bc8842b16b9d069785882
ToppCell	wk_15-18-Epithelial-Proximal_epithelial\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	CFAP141 MARCHF10 CCDC39	5.51e-04	194	37	3	b0477583301dc6d9767b667bd2f8f94fbfaa6f81
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SOX5 MYOCD CRIM1	5.51e-04	194	37	3	ab9cad697f9209d2889bc02b43b502dfeb2ebfef
ToppCell	368C-Fibroblasts-Fibroblast-G\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	MACF1 DST CRIM1	5.51e-04	194	37	3	e4d7e9709ce42d4610e44d3445927eefbcbb9eff
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro1_(4)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	MACF1 MAML2 DST	5.51e-04	194	37	3	71d3c7448b1734de54187f902f65649f9283bd4c
ToppCell	COVID-19-lung-Pericytes/_Smooth_Muscle\|lung / Disease (COVID-19 only), tissue and cell type	SOX5 MYOCD CRIM1	5.51e-04	194	37	3	5e1e0513a54ec4cf0b247ec85c9fbc68dfac1da3
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SOX5 SEC24D MYOCD	5.59e-04	195	37	3	dd281a249854800f737dc22e0f375f66dfb5cf5f
ToppCell	PND01-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_mature\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SOX5 CRIM1 KCNT1	5.59e-04	195	37	3	7a32a8535c29b819dacba901d0658280a2631c94
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SOX5 SEC24D MYOCD	5.59e-04	195	37	3	49c99553629cdd83ee56a2e508d5bc8d34b8507b
ToppCell	PND01-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SOX5 CRIM1 KCNT1	5.59e-04	195	37	3	4a5d2f62aad5817d077177bf8b4ff0e46d3b8d97
ToppCell	wk_15-18-Epithelial-Proximal_epithelial-Ciliated\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	CFAP141 MARCHF10 CCDC39	5.59e-04	195	37	3	cfcf554b436083179dea1d6fd6e3a800ea2430fe
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature5_(6)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	SOX5 MACF1 DST	5.59e-04	195	37	3	0e55fa5b3cbeb7baee3d4ac272a3bf80381ec937
ToppCell	facs-Brain_Myeloid-Hippocampus\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MACF1 DST BMP2K	5.59e-04	195	37	3	a1478021a3ed0e779716393124ca2a7770c433b7
ToppCell	Bronchial-NucSeq\|Bronchial / Cell types per location group and 10X technology with lineage, and cell group designations	SOX5 MAML2 SIK3	5.67e-04	196	37	3	ab53c742866945545a92e2e61850d63c80d9a2a6
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	MACF1 MAML2 DST	5.67e-04	196	37	3	1450cb69c5bf469e97c03bf1890f6f7c54165b8a
ToppCell	COVID-19-lung-Pericytes/_Smooth_Muscle\|COVID-19 / Disease (COVID-19 only), tissue and cell type	SOX5 MYOCD CRIM1	5.67e-04	196	37	3	754a3613340932563cd8424d775e18b93c3a1aaa
ToppCell	PND01-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SOX5 CRIM1 KCNT1	5.67e-04	196	37	3	6708026bafd19c35c5c4e81911344d36a0f508cd
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature3_(17)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	MACF1 MAML2 DST	5.76e-04	197	37	3	31a1852911bda38543916585fda34255fd62a134
ToppCell	(5)_Fibroblasts-(5)_Fibroblast-G\|(5)_Fibroblasts / Lung cell shreds - cell class (v4) and cell subclass (v4)	MACF1 DST CRIM1	5.76e-04	197	37	3	a21a710c824f9e5c7ef1674168d1ce5aef85bd35
ToppCell	Parenchymal-NucSeq\|Parenchymal / Cell types per location group and 10X technology with lineage, and cell group designations	SOX5 MAML2 SIK3	5.84e-04	198	37	3	1996373bdccc55aac347d349bd22f6aad6d0c668
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	MACF1 MAML2 DST	5.84e-04	198	37	3	17dc055e2a289496d9c5cdbf3297bdf906dc6d22
ToppCell	normal_Lung-Fibroblasts-COL13A1+_matrix_FBs\|Fibroblasts / Location, Cell class and cell subclass	MACF1 DST CRIM1	5.84e-04	198	37	3	e0e47cf65774191981840b22905b2094b95abe0f
ToppCell	medial-Epithelial-Ciliated-2\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CFAP141 MARCHF10 CCDC39	5.93e-04	199	37	3	526002f16bbf61cf086278d45a401cc0b0b757a8
ToppCell	Tracheal-NucSeq\|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations	SOX5 MAML2 SIK3	5.93e-04	199	37	3	94b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCell	distal-Epithelial-Ciliated-2\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CFAP141 MARCHF10 CCDC39	5.93e-04	199	37	3	2de1fe124737a6cca4b3805ab3056f9d9d7c16c7
ToppCell	medial-Epithelial-Ciliated\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CFAP141 MARCHF10 CCDC39	5.93e-04	199	37	3	a2daa42b100c422dc8c04fb7d2ebf54293eef574
ToppCell	medial-2-Epithelial-Ciliated\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CFAP141 MARCHF10 CCDC39	5.93e-04	199	37	3	c02f04a5aa79ee0cf427f6e94b93ceab38ebbcd7
ToppCell	343B-Fibroblasts-Fibroblast-G\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	MACF1 DST CRIM1	5.93e-04	199	37	3	212e89d097753790061310373a1fafba773488b6
ToppCell	343B-Fibroblasts-Fibroblast-G-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	MACF1 DST CRIM1	5.93e-04	199	37	3	14b676aa289c0578a37be32cec3ea285c79d97cc
ToppCell	Biopsy_Control_(H.)-Epithelial-Ciliated\|Biopsy_Control_(H.) / Sample group, Lineage and Cell type	CFAP141 MARCHF10 CCDC39	6.01e-04	200	37	3	9ae434c78e08adf95da49c85616e3ca72d1227bf
ToppCell	Bronchial-10x5prime-Epithelial-Epi_airway_ciliated\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	CFAP141 MARCHF10 CCDC39	6.01e-04	200	37	3	52aef65f01b06cd98056f17977efe525aee6eb6f
Drug	AC1L2FXT	PHC3 PHC1 PHC2	4.70e-07	10	37	3	CID000071316
Drug	AC1L2XIZ	PHC3 PHC1 PHC2	8.60e-07	12	37	3	CID000104803
Drug	AC1NDZBW	PHC3 MYOCD ITCH PHC1 PHC2	1.25e-05	187	37	5	CID004634040
Drug	Galanthamine hydrobromide [1953-04-4]; Down 200; 10.8uM; MCF7; HT_HG-U133A	ASTN2 CRIM1 TFG RFWD3 YLPM1	1.49e-05	194	37	5	4772_DN
Drug	Flurandrenolide [1524-88-5]; Down 200; 9.2uM; MCF7; HT_HG-U133A	PHC3 SEC24D CRIM1 ARHGEF11 BMP2K	1.49e-05	194	37	5	6039_DN
Disease	cancer (implicated_via_orthology)	SAV1 MACF1 PHC3 DST PHC1 PHC2	8.23e-07	268	36	6	DOID:162 (implicated_via_orthology)
Disease	Headache	MACF1 ASTN2 ZCCHC2	6.60e-05	64	36	3	HP_0002315
Disease	FEV/FEC ratio	SOX5 ASTN2 MAML2 ITCH DST CRIM1 EPC1 YLPM1	9.40e-05	1228	36	8	EFO_0004713
Disease	microphthalmia (implicated_via_orthology)	CRIM1 HCCS	9.48e-05	12	36	2	DOID:10629 (implicated_via_orthology)
Disease	total blood protein measurement	SOX5 MACF1 ZSWIM8 MAML2 CRIM1	2.04e-04	449	36	5	EFO_0004536
Disease	response to perphenazine	SOX5 ASTN2	4.62e-04	26	36	2	GO_0097334
Disease	red blood cell density measurement	MAML2 SIK3 DST ARHGEF11 BMP2K PHC2	6.27e-04	880	36	6	EFO_0007978
Disease	wellbeing measurement	SOX5 CFAP141 SIK3 MARCHF10 YLPM1	1.44e-03	692	36	5	EFO_0007869

Protein segments in the cluster

Peptide	Gene	Start	Entry
QGQQMREAQFLYAQK	ARID3B	31	Q8IVW6
EQYQQHQQQLALMQK	EPC1	586	Q9H2F5
DYHQQFRHVQNNLMR	COG4	326	Q9H9E3
RNIIQHFENNQQYDA	ARHGEF11	566	O15085
MYQNEQDNVNKHTEQ	ANKRD30A	1301	Q9BXX3
DMYNIIRIHNQNNEQ	HCCS	146	P53701
LQDAYMQQYQHATQQ	BMP2K	496	Q9NSY1
QHVNQGQVFQMTFRE	ASTN2	786	O75129
KQQEIMYSQDFHIQQ	CCDC39	446	Q9UFE4
MEYDVQVQLNHAEQQ	RFWD3	6	Q6PCD5
NEENMQLAQAYLNQF	MMP27	26	Q9H306
QLQHNYIQMYRRNRQ	LZTS2	616	Q9BRK4
EAYQQQIEMERLNHQ	DST	6316	Q03001
VNLGYLQDEMNDHQN	KCNT1	1156	Q5JUK3
YQQQIEMEKLNHQGE	MACF1	2291	O94854
LIRQLQEQHYQQYMQ	ACBD3	276	Q9H3P7
AAQYLQQMYAAQQQH	PHC3	61	Q8NDX5
QQQQQHRFSYLGMHQ	MYOCD	306	Q8IZQ8
AGMGYQVSQQQRQDQ	MAML2	701	Q8IZL2
QLQGAMQQFNQRFIY	ITCH	406	Q96J02
MQQFNQRFIYGNQDL	ITCH	411	Q96J02
MQKQNHLQADNFYQT	CRIM1	1021	Q9NZV1
NMIEFYQKHQQSQAQ	MARCHF10	726	Q8NA82
EHQQYQQELNQMGKA	CFAP141	81	Q5VU69
QQQEYQELFRHMNQG	SIK3	1011	Q9Y2K2
YNNFQMHLDRQQFLN	SEC24D	661	O94855
RAQNNSAHGDYMQNN	ZCCHC2	311	Q9C0B9
YNHDLFQRMPQNQGR	SAV1	161	Q9H4B6
AAQYLQQMYAAQQQH	PHC2	71	Q8IXK0
NNQNFQQRYHAEEVE	ZCCHC8	266	Q6NZY4
VYEVRMENNQPQFNN	SAGE2P	216	A6NJ88
AGQIEGQMYQQYQQQ	TFG	236	Q92734
NDRFNYVVMQLQGRN	TTBK2	86	Q6IQ55
QRISMRFQEYHIQQN	TIMM9	61	Q9Y5J7
QPNAAQYFHQFMLQQ	PHC1	46	P78364
QQHQQHRVGFQYQGI	YLPM1	391	P49750
MQLRHYEMQQQQFQH	YLPM1	436	P49750
AFHQLVQRCQQAYMQ	ZSWIM8	1756	A7E2V4
NRRQEMRQYFNVGQQ	SOX5	651	P35711
NQHVFALEQMEYQNE	MYO3B	751	Q8WXR4