Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	kinase activity	TNIK PMS2P1 NPR2 TRPM7 STYK1 SNRK MAP3K4 MST1R PHKA2 PIK3CB PI4KB PPIP5K1 PRKCH EIF2AK4 ULK1 COASY	2.08e-05	764	124	16	GO:0016301
GeneOntologyMolecularFunction	transferase activity, transferring phosphorus-containing groups	TNIK PMS2P1 NPR2 TRPM7 STYK1 SNRK MAP3K4 MST1R PHKA2 PIK3CB PI4KB PPIP5K1 PRKCH TNKS EIF2AK4 ULK1 COASY	6.94e-05	938	124	17	GO:0016772
GeneOntologyMolecularFunction	phosphotransferase activity, alcohol group as acceptor	TNIK NPR2 TRPM7 STYK1 SNRK MAP3K4 MST1R PHKA2 PIK3CB PI4KB PRKCH EIF2AK4 ULK1 COASY	1.32e-04	709	124	14	GO:0016773
GeneOntologyMolecularFunction	protein kinase activity	TNIK NPR2 TRPM7 STYK1 SNRK MAP3K4 MST1R PHKA2 PIK3CB PRKCH EIF2AK4 ULK1	3.62e-04	600	124	12	GO:0004672
GeneOntologyBiologicalProcess	cellular response to amino acid starvation	RRAGB RRAGC PRKCH EIF2AK4 ULK1	2.16e-05	56	124	5	GO:0034198
GeneOntologyBiologicalProcess	response to amino acid starvation	RRAGB RRAGC PRKCH EIF2AK4 ULK1	3.29e-05	61	124	5	GO:1990928
Domain	DAG/PE-bd	RASGRP4 CHN1 CHN2 PRKCH	1.01e-05	21	124	4	IPR020454
Domain	CHN1/CHN2	CHN1 CHN2	4.37e-05	2	124	2	IPR017356
Domain	Kinase-like_dom	TNIK NPR2 TRPM7 STYK1 SNRK MAP3K4 MST1R PIK3CB PI4KB PRKCH EIF2AK4 ULK1 SOS1	6.50e-05	542	124	13	IPR011009
Domain	BMP_1/tolloid-like	BMP1 TLL2	1.31e-04	3	124	2	IPR015446
Domain	Gtr1_RagA	RRAGB RRAGC	2.60e-04	4	124	2	IPR006762
Domain	Gtr1_RagA	RRAGB RRAGC	2.60e-04	4	124	2	PF04670
Domain	Ras-like_Gua-exchang_fac_N	RASGRP4 SOS1 SOS2	4.01e-04	22	124	3	IPR000651
Domain	RASGEF_NTER	RASGRP4 SOS1 SOS2	4.01e-04	22	124	3	PS50212
Domain	-	ALDH1L1 FASN	4.32e-04	5	124	2	1.10.1200.10
Domain	PHOSPHOPANTETHEINE	ALDH1L1 FASN	4.32e-04	5	124	2	PS00012
Domain	PP-binding	ALDH1L1 FASN	4.32e-04	5	124	2	PF00550
Domain	ACP_DOMAIN	ALDH1L1 FASN	4.32e-04	5	124	2	PS50075
Domain	C1_1	RASGRP4 CHN1 CHN2 PRKCH	5.57e-04	57	124	4	PF00130
Domain	Peptidase_M12A	BMP1 TLL2	6.45e-04	6	124	2	IPR001506
Domain	Astacin	BMP1 TLL2	6.45e-04	6	124	2	PF01400
Domain	PP-bd_ACP	ALDH1L1 FASN	6.45e-04	6	124	2	IPR009081
Domain	RASGEF	RASGRP4 SOS1 SOS2	6.64e-04	26	124	3	PS00720
Domain	ZF_DAG_PE_1	RASGRP4 CHN1 CHN2 PRKCH	8.65e-04	64	124	4	PS00479
Domain	ZF_DAG_PE_2	RASGRP4 CHN1 CHN2 PRKCH	8.65e-04	64	124	4	PS50081
Domain	HIS_ACID_PHOSPHAT_2	PPIP5K1 PXYLP1	8.98e-04	7	124	2	PS00778
Domain	HIS_ACID_PHOSPHAT_1	PPIP5K1 PXYLP1	8.98e-04	7	124	2	PS00616
Domain	C1	RASGRP4 CHN1 CHN2 PRKCH	9.17e-04	65	124	4	SM00109
Domain	RASGEF_CAT	RASGRP4 SOS1 SOS2	9.20e-04	29	124	3	PS50009
Domain	PE/DAG-bd	RASGRP4 CHN1 CHN2 PRKCH	9.71e-04	66	124	4	IPR002219
Domain	RasGEF	RASGRP4 SOS1 SOS2	1.02e-03	30	124	3	PF00617
Domain	-	RASGRP4 SOS1 SOS2	1.02e-03	30	124	3	1.10.840.10
Domain	RASGEF_cat_dom	RASGRP4 SOS1 SOS2	1.02e-03	30	124	3	IPR001895
Domain	RasGEF	RASGRP4 SOS1 SOS2	1.02e-03	30	124	3	SM00147
Domain	Ras_GEF_dom	RASGRP4 SOS1 SOS2	1.02e-03	30	124	3	IPR023578
Domain	His_Pase_clade-2	PPIP5K1 PXYLP1	1.19e-03	8	124	2	IPR000560
Domain	His_Phos_2	PPIP5K1 PXYLP1	1.19e-03	8	124	2	PF00328
Domain	UCH	USP17L4 USP17L1 USP7 USP17L3	1.28e-03	71	124	4	PF00443
Domain	USP_2	USP17L4 USP17L1 USP7 USP17L3	1.28e-03	71	124	4	PS00973
Domain	USP_3	USP17L4 USP17L1 USP7 USP17L3	1.34e-03	72	124	4	PS50235
Domain	USP_dom	USP17L4 USP17L1 USP7 USP17L3	1.34e-03	72	124	4	IPR028889
Domain	Peptidase_C19_UCH	USP17L4 USP17L1 USP7 USP17L3	1.34e-03	72	124	4	IPR001394
Domain	Calx_beta	ADGRV1 FREM1	1.53e-03	9	124	2	IPR003644
Domain	Calx-beta	ADGRV1 FREM1	1.53e-03	9	124	2	PF03160
Domain	-	WDR76 PPWD1 WDFY4 MST1R RPTOR CFAP57 EIF3I RMC1	1.73e-03	333	124	8	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	WDR76 PPWD1 WDFY4 MST1R RPTOR CFAP57 EIF3I RMC1	1.79e-03	335	124	8	IPR015943
Domain	PI_Kinase	PIK3CB PI4KB	1.90e-03	10	124	2	IPR015433
Domain	PInositide-3_kin_accessory_dom	PIK3CB PI4KB	1.90e-03	10	124	2	IPR001263
Domain	PIK_HELICAL	PIK3CB PI4KB	1.90e-03	10	124	2	PS51545
Domain	EGF_CA	BMP1 TLL2 NID1 NPNT	2.58e-03	86	124	4	PF07645
Domain	PsdUridine_synth_cat_dom	TRUB2 PUS7	3.25e-03	13	124	2	IPR020103
Domain	WD40_repeat_dom	WDR76 PPWD1 WDFY4 RPTOR CFAP57 EIF3I RMC1	3.71e-03	297	124	7	IPR017986
Domain	Dynein_HC_stalk	DNHD1 DNAH11	3.78e-03	14	124	2	IPR024743
Domain	Dynein_heavy_dom-2	DNHD1 DNAH11	3.78e-03	14	124	2	IPR013602
Domain	DHC_N2	DNHD1 DNAH11	3.78e-03	14	124	2	PF08393
Domain	Ras_G-nucl-exch_fac_CS	SOS1 SOS2	3.78e-03	14	124	2	IPR019804
Domain	MT	DNHD1 DNAH11	3.78e-03	14	124	2	PF12777
Domain	uDENN	DENND5B SBF2	3.78e-03	14	124	2	SM00800
Domain	EGF_Ca-bd_CS	BMP1 TLL2 NID1 NPNT	3.99e-03	97	124	4	IPR018097
Domain	EGF_CA	BMP1 TLL2 NID1 NPNT	4.29e-03	99	124	4	PS01187
Domain	DHC_fam	DNHD1 DNAH11	4.34e-03	15	124	2	IPR026983
Domain	uDENN	DENND5B SBF2	4.34e-03	15	124	2	PF03456
Domain	Dynein_heavy	DNHD1 DNAH11	4.34e-03	15	124	2	PF03028
Domain	PI3/4_kinase_CS	PIK3CB PI4KB	4.34e-03	15	124	2	IPR018936
Domain	Dynein_heavy_dom	DNHD1 DNAH11	4.34e-03	15	124	2	IPR004273
Domain	EGF	RELN BMP1 TLL2 NID1 NAGPA NPNT	4.85e-03	235	124	6	SM00181
Domain	EGF_3	RELN BMP1 TLL2 NID1 NAGPA NPNT	4.85e-03	235	124	6	PS50026
Domain	DENN	DENND5B SBF2	4.94e-03	16	124	2	SM00799
Domain	-	PIK3CB PI4KB	4.94e-03	16	124	2	1.10.1070.11
Domain	DENN	DENND5B SBF2	4.94e-03	16	124	2	PF02141
Domain	dDENN	DENND5B SBF2	4.94e-03	16	124	2	PF03455
Domain	PI3Kc	PIK3CB PI4KB	4.94e-03	16	124	2	SM00146
Domain	UDENN	DENND5B SBF2	4.94e-03	16	124	2	PS50946
Domain	DDENN	DENND5B SBF2	4.94e-03	16	124	2	PS50947
Domain	dDENN	DENND5B SBF2	4.94e-03	16	124	2	SM00801
Domain	dDENN_dom	DENND5B SBF2	4.94e-03	16	124	2	IPR005112
Domain	uDENN_dom	DENND5B SBF2	4.94e-03	16	124	2	IPR005113
Domain	DENN	DENND5B SBF2	4.94e-03	16	124	2	PS50211
Domain	DENN_dom	DENND5B SBF2	4.94e-03	16	124	2	IPR001194
Domain	Ald_DH_CS_GLU	ALDH1L1 ALDH4A1	4.94e-03	16	124	2	IPR029510
Domain	Prot_kinase_dom	TNIK NPR2 STYK1 SNRK MAP3K4 MST1R PRKCH EIF2AK4 ULK1	5.35e-03	489	124	9	IPR000719
Domain	EGF-type_Asp/Asn_hydroxyl_site	BMP1 TLL2 NID1 NPNT	5.46e-03	106	124	4	IPR000152
Domain	Ald_DH_CS_CYS	ALDH1L1 ALDH4A1	5.57e-03	17	124	2	IPR016160
Domain	PROTEIN_KINASE_DOM	TNIK NPR2 STYK1 SNRK MAP3K4 MST1R PRKCH EIF2AK4 ULK1	5.64e-03	493	124	9	PS50011
Domain	PI3_PI4_kinase	PIK3CB PI4KB	6.24e-03	18	124	2	PF00454
Domain	PI3_4_KINASE_1	PIK3CB PI4KB	6.24e-03	18	124	2	PS00915
Domain	PI3_4_KINASE_2	PIK3CB PI4KB	6.24e-03	18	124	2	PS00916
Domain	ALDEHYDE_DEHYDR_CYS	ALDH1L1 ALDH4A1	6.24e-03	18	124	2	PS00070
Domain	ALDEHYDE_DEHYDR_GLU	ALDH1L1 ALDH4A1	6.24e-03	18	124	2	PS00687
Domain	PI3/4_kinase_cat_dom	PIK3CB PI4KB	6.24e-03	18	124	2	IPR000403
Domain	PI3_4_KINASE_3	PIK3CB PI4KB	6.24e-03	18	124	2	PS50290
Domain	EGF-like_dom	RELN BMP1 TLL2 NID1 NAGPA NPNT	6.39e-03	249	124	6	IPR000742
Pathway	WP_TARGET_OF_RAPAMYCIN_SIGNALING	RRAGB RRAGC RPTOR ULK1	1.05e-04	36	97	4	M39635
Pathway	KEGG_MEDICUS_VARIANT_DUPLICATION_OR_MUTATION_ACTIVATED_FLT3_TO_RAS_PI3K_SIGNALING_PATHWAY	PIK3CB SOS1 SOS2	1.09e-04	14	97	3	M47390
Pathway	KEGG_MEDICUS_REFERENCE_FLCN_MTORC1_SIGNALING_PATHWAY	RRAGB RRAGC RPTOR	1.09e-04	14	97	3	M47922
Pathway	KEGG_MEDICUS_REFERENCE_GATOR1_MTORC1_SIGNALING_PATHWAY	RRAGB RRAGC RPTOR	1.09e-04	14	97	3	M47918
Pathway	WP_INSULIN_SIGNALING	KIF3A MAP3K4 TBC1D4 PIK3CB PRKCH SOS1 SOS2	1.16e-04	160	97	7	MM15956
Pathway	WP_INSULIN_SIGNALING	KIF3A MAP3K4 TBC1D4 PIK3CB PRKCH SOS1 SOS2	1.16e-04	160	97	7	M39482
Pathway	KEGG_MEDICUS_REFERENCE_EGF_EGFR_RAS_PI3K_SIGNALING_PATHWAY	PIK3CB SOS1 SOS2	1.35e-04	15	97	3	M47389
Pathway	KEGG_MEDICUS_REFERENCE_FLT3LG_FLT3_RAS_PI3K_SIGNALING_PATHWAY	PIK3CB SOS1 SOS2	1.35e-04	15	97	3	M47475
Pathway	WP_ANGIOPOIETINLIKE_PROTEIN_8_REGULATORY_PATHWAY	MAP3K4 FASN PIK3CB RPTOR SOS1 SOS2	2.96e-04	132	97	6	M39338
Pathway	KEGG_INSULIN_SIGNALING_PATHWAY	PHKA2 FASN PIK3CB RPTOR SOS1 SOS2	3.61e-04	137	97	6	M18155
Pubmed	TBK1 Provides Context-Selective Support of the Activated AKT/mTOR Pathway in Lung Cancer.	RRAGB RRAGC RPTOR ULK1	1.70e-07	14	128	4	28716898
Pubmed	Targeting of EGFR by a combination of antibodies mediates unconventional EGFR trafficking and degradation.	PIK3CB RPTOR SOS1 SOS2	6.50e-07	19	128	4	31959764
Pubmed	CDK4/6-dependent activation of DUB3 regulates cancer metastasis through SNAIL1.	USP17L4 USP17L1 USP7 USP17L3	6.50e-07	19	128	4	28067227
Pubmed	The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1.	RRAGB RRAGC RPTOR	9.66e-07	6	128	3	18497260
Pubmed	Frontline Science: TNF-α and GM-CSF1 priming augments the role of SOS1/2 in driving activation of Ras, PI3K-γ, and neutrophil proinflammatory responses.	RASGRP4 SOS1 SOS2	1.69e-06	7	128	3	30720883
Pubmed	Amino acid-dependent NPRL2 interaction with Raptor determines mTOR Complex 1 activation.	RRAGB RRAGC RPTOR	2.69e-06	8	128	3	26582740
Pubmed	Amino acids activate mammalian target of rapamycin (mTOR) complex 1 without changing Rag GTPase guanyl nucleotide charging.	RRAGB RRAGC RPTOR	4.02e-06	9	128	3	24337580
Pubmed	p62 is a key regulator of nutrient sensing in the mTORC1 pathway.	RRAGB RRAGC RPTOR	4.02e-06	9	128	3	21981924
Pubmed	Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway.	RRAGB RRAGC RPTOR	5.73e-06	10	128	3	22424946
Pubmed	High Dub3 expression in mouse ESCs couples the G1/S checkpoint to pluripotency.	USP17L4 USP17L1 USP17L3	5.73e-06	10	128	3	24207026
Pubmed	Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1.	RRAGB RRAGC RPTOR	7.86e-06	11	128	3	25567906
Pubmed	Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids.	RRAGB RRAGC RPTOR	1.05e-05	12	128	3	20381137
Pubmed	Cell cycle-dependent expression of Dub3, Nanog and the p160 family of nuclear receptor coactivators (NCoAs) in mouse embryonic stem cells.	USP17L4 USP17L1 USP17L3	1.05e-05	12	128	3	24695638
Pubmed	SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1.	RRAGB RRAGC RPTOR	1.05e-05	12	128	3	25561175
Pubmed	Human and mouse proteases: a comparative genomic approach.	USP17L4 USP17L1 FREM1 USP7 USP17L3	1.28e-05	81	128	5	12838346
Pubmed	Fatty acid synthase expression associated with NAC1 is a potential therapeutic target in ovarian clear cell carcinomas.	NACC1 FASN	1.34e-05	2	128	2	22653145
Pubmed	Association between KIR gene polymorphisms and type 1 diabetes mellitus (T1DM) susceptibility: A PRISMA-compliant meta-analysis.	KIR2DL1 KIR2DS1	1.34e-05	2	128	2	29384924
Pubmed	Recognition of peptide-MHC class I complexes by activating killer immunoglobulin-like receptors.	KIR2DL1 KIR2DS1	1.34e-05	2	128	2	16141329
Pubmed	A homologue of the Drosophila Son of sevenless gene maps to mouse chromosome 17.	SOS1 SOS2	1.34e-05	2	128	2	8307589
Pubmed	The Size of Activating and Inhibitory Killer Ig-like Receptor Nanoclusters Is Controlled by the Transmembrane Sequence and Affects Signaling.	KIR2DL1 KIR2DS1	1.34e-05	2	128	2	27210755
Pubmed	KIR2DS1 and KIR2DL1-C245 Dominantly Repress NK Cell Degranulation Triggered by Monoclonal or Bispecific Antibodies, whereas Education by Uptuning Inhibitory Killer Ig-related Receptors Exerts No Advantage in Ab-dependent Cellular Cytotoxicity.	KIR2DL1 KIR2DS1	1.34e-05	2	128	2	38240527
Pubmed	Identification of two new mutations in the GPR98 and the PDE6B genes segregating in a Tunisian family.	PDE6B ADGRV1	1.34e-05	2	128	2	18854872
Pubmed	Lifetime study in mice after acute low-dose ionizing radiation: a multifactorial study with special focus on cataract risk.	ERCC2 PDE6B	1.34e-05	2	128	2	29327260
Pubmed	Critical Requirement of SOS1 for Development of BCR/ABL-Driven Chronic Myelogenous Leukemia.	SOS1 SOS2	1.34e-05	2	128	2	36010887
Pubmed	Prognostic significance of serum chemerin levels in patients with non-small cell lung cancer.	CHN1 CHN2	1.34e-05	2	128	2	28160556
Pubmed	Absence of both Sos-1 and Sos-2 in peripheral CD4(+) T cells leads to PI3K pathway activation and defects in migration.	SOS1 SOS2	1.34e-05	2	128	2	25973715
Pubmed	Investigation of killer cell immunoglobulin-like receptor gene diversity, KIR2DL1 and KIR2DS1.	KIR2DL1 KIR2DS1	1.34e-05	2	128	2	18643963
Pubmed	Identification of murine homologues of the Drosophila son of sevenless gene: potential activators of ras.	SOS1 SOS2	1.34e-05	2	128	2	1631150
Pubmed	SOS2 Comes to the Fore: Differential Functionalities in Physiology and Pathology.	SOS1 SOS2	1.34e-05	2	128	2	34205562
Pubmed	The Ras-specific exchange factors mouse Sos1 (mSos1) and mSos2 are regulated differently: mSos2 contains ubiquitination signals absent in mSos1.	SOS1 SOS2	1.34e-05	2	128	2	9372945
Pubmed	Chromosomal localization of two genes encoding human ras exchange factors: SOS1 maps to the 2p22-->p16 region and SOS2 to the 14q21-->q22 region of the human genome.	SOS1 SOS2	1.34e-05	2	128	2	8275713
Pubmed	A Natural Occurring Mouse Model with Adgrv1 Mutation of Usher Syndrome 2C and Characterization of its Recombinant Inbred Strains.	PDE6B ADGRV1	1.34e-05	2	128	2	29961073
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	ERCC2 SETD1B RDH10 HIP1R FBXO46 CASZ1 FAM83H MST1R FASN MROH1 RPTOR SBF2 USP7 ULK1 PC	1.43e-05	1105	128	15	35748872
Pubmed	ES cell neural differentiation reveals a substantial number of novel ESTs.	USP17L4 USP17L1 USP17L3	1.72e-05	14	128	3	11793228
Pubmed	Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver.	THSD4 COL6A2 EMILIN2 CSTB NID1 NPNT	2.29e-05	153	128	6	25037231
Pubmed	Molecular genetics of successful smoking cessation: convergent genome-wide association study results.	THSD4 TNIK TDRD5 CHN2 WDFY4	3.73e-05	101	128	5	18519826
Pubmed	Prognostic role of KIR genes and HLA-C after hematopoietic stem cell transplantation in a patient cohort with acute myeloid leukemia from a consanguineous community.	KIR2DL1 KIR2DS1	4.02e-05	3	128	2	29549293
Pubmed	A role for stargazin in experience-dependent plasticity.	CACNA1A PDE6B	4.02e-05	3	128	2	24882000
Pubmed	Structural basis for the substrate specificity of bone morphogenetic protein 1/tolloid-like metalloproteases.	BMP1 TLL2	4.02e-05	3	128	2	18824173
Pubmed	Structural evidence for feedback activation by Ras.GTP of the Ras-specific nucleotide exchange factor SOS.	SOS1 SOS2	4.02e-05	3	128	2	12628188
Pubmed	Gene for the activating natural killer cell receptor, KIR2DS1, is associated with susceptibility to psoriasis vulgaris.	KIR2DL1 KIR2DS1	4.02e-05	3	128	2	15310528
Pubmed	Differential Role of the RasGEFs Sos1 and Sos2 in Mouse Skin Homeostasis and Carcinogenesis.	SOS1 SOS2	4.02e-05	3	128	2	29844066
Pubmed	Role of chimaerins, a group of Rac-specific GTPase activating proteins, in T-cell receptor signaling.	CHN1 CHN2	4.02e-05	3	128	2	18249095
Pubmed	α2-Chimaerin is essential for neural stem cell homeostasis in mouse adult neurogenesis.	CHN1 CHN2	4.02e-05	3	128	2	31209021
Pubmed	Genetic analysis of the role of proteolysis in the activation of latent myostatin.	BMP1 TLL2	4.02e-05	3	128	2	18286185
Pubmed	TDRD5 binds piRNA precursors and selectively enhances pachytene piRNA processing in mice.	TDRD5 MOV10L1	4.02e-05	3	128	2	29317670
Pubmed	Differential interactions of human Sos1 and Sos2 with Grb2.	SOS1 SOS2	4.02e-05	3	128	2	7629138
Pubmed	Functional redundancy of Sos1 and Sos2 for lymphopoiesis and organismal homeostasis and survival.	SOS1 SOS2	4.02e-05	3	128	2	24043312
Pubmed	EphA4-dependent axon guidance is mediated by the RacGAP alpha2-chimaerin.	CHN1 CHN2	4.02e-05	3	128	2	17785182
Pubmed	Effects of thyrotropin releasing hormone on cerebellar mutant mice--a kinesiological comparison between rolling mouse Nagoya, weaver and reeler.	CACNA1A RELN	4.02e-05	3	128	2	6811784
Pubmed	Uterine NK cells underexpress KIR2DL1/S1 and LILRB1 in reproductive failure.	KIR2DL1 KIR2DS1	4.02e-05	3	128	2	36713400
Pubmed	ELAC1 Repairs tRNAs Cleaved during Ribosome-Associated Quality Control.	ANKZF1 ELAC1	4.02e-05	3	128	2	32075755
Pubmed	Rag GTPases suppress PRL-3 degradation and predict poor clinical diagnosis of cancer patients with low PRL-3 mRNA expression.	RRAGB RRAGC	4.02e-05	3	128	2	34482023
Pubmed	Deconstructing Ras signaling in the thymus.	SOS1 SOS2	4.02e-05	3	128	2	22586275
Pubmed	Disassembly of Son-of-sevenless proteins from Grb2 during p21ras desensitization by insulin.	SOS1 SOS2	4.02e-05	3	128	2	7829473
Pubmed	RACK1 downregulates levels of the pro-apoptotic protein Fem1b in apoptosis-resistant colon cancer cells.	ELOC FEM1B	4.02e-05	3	128	2	19855191
Pubmed	DUB-1, a deubiquitinating enzyme with growth-suppressing activity.	USP17L4 USP17L1 USP17L3	6.17e-05	21	128	3	8622927
Pubmed	DUB-1A, a novel deubiquitinating enzyme subfamily member, is polyubiquitinated and cytokine-inducible in B-lymphocytes.	USP17L4 USP17L1 USP17L3	6.17e-05	21	128	3	14583620
Pubmed	DUB-2A, a new member of the DUB subfamily of hematopoietic deubiquitinating enzymes.	USP17L4 USP17L1 USP17L3	6.17e-05	21	128	3	11468161
Pubmed	The murine DUB-1 gene is specifically induced by the betac subunit of interleukin-3 receptor.	USP17L4 USP17L1 USP17L3	6.17e-05	21	128	3	8756639
Pubmed	Lymphocyte-specific murine deubiquitinating enzymes induced by cytokines.	USP17L4 USP17L1 USP17L3	6.17e-05	21	128	3	12447969
Pubmed	DUB-1, a fate determinant of dynein heavy chain in B-lymphocytes, is regulated by the ubiquitin-proteasome pathway.	USP17L4 USP17L1 USP17L3	6.17e-05	21	128	3	18980247
Pubmed	JAK2 is required for induction of the murine DUB-1 gene.	USP17L4 USP17L1 USP17L3	7.12e-05	22	128	3	9154835
Pubmed	Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.	SLC25A27 ALDH1L1 ECSIT TRUB2 ME3 MLYCD FEM1B SLC25A52 DHX32 ALDH4A1 SAMM50 COASY PC CLUH	7.95e-05	1136	128	14	34800366
Pubmed	Crystal structure of the Gtr1p-Gtr2p complex reveals new insights into the amino acid-induced TORC1 activation.	RRAGC RPTOR	8.02e-05	4	128	2	21816923
Pubmed	FGF-induced vesicular release of Sonic hedgehog and retinoic acid in leftward nodal flow is critical for left-right determination.	KIF3A DNAH11	8.02e-05	4	128	2	15889083
Pubmed	Left-right development: the roles of nodal cilia.	KIF3A DNAH11	8.02e-05	4	128	2	10704402
Pubmed	Peptide-specific engagement of the activating NK cell receptor KIR2DS1.	KIR2DL1 KIR2DS1	8.02e-05	4	128	2	28546555
Pubmed	Three recessive mutations producing disproportionate dwarfing in mice: achondroplasia, brachymorphic, and stubby.	NPR2 HPS1	8.02e-05	4	128	2	5713631
Pubmed	Investigation of activating and inhibitory killer cell immunoglobulin-like receptors and their putative ligands in type 1 diabetes (T1D).	KIR2DL1 KIR2DS1	8.02e-05	4	128	2	26542066
Pubmed	Adenylyl cyclase 6 plays a minor role in the mouse inner ear and retina.	PDE6B ADGRV1	8.02e-05	4	128	2	37127773
Pubmed	Molecular motors: the driving force behind mammalian left-right development.	KIF3A DNAH11	8.02e-05	4	128	2	10652513
Pubmed	Central noradrenaline metabolism in cerebellar ataxic mice.	CACNA1A RELN	8.02e-05	4	128	2	6123371
Pubmed	Three types of cilia including a novel 9+4 axoneme on the notochordal plate of the rabbit embryo.	KIF3A DNAH11	8.02e-05	4	128	2	17061268
Pubmed	A new member of the amphiphysin family connecting endocytosis and signal transduction pathways.	SOS1 SOS2	8.02e-05	4	128	2	9182529
Pubmed	EPOP Interacts with Elongin BC and USP7 to Modulate the Chromatin Landscape.	ELOC USP7	8.02e-05	4	128	2	27863226
Pubmed	Role of Ca2+ transients at the node of the mouse embryo in breaking of left-right symmetry.	KIF3A DNAH11	8.02e-05	4	128	2	32743070
Pubmed	Ribosomes guide pachytene piRNA formation on long intergenic piRNA precursors.	TDRD5 MOV10L1	8.02e-05	4	128	2	32015435
Pubmed	Alternative ZAP70-p38 signals prime a classical p38 pathway through LAT and SOS to support regulatory T cell differentiation.	SOS1 SOS2	8.02e-05	4	128	2	31337738
Pubmed	Heterozygous mutations of FREM1 are associated with an increased risk of isolated metopic craniosynostosis in humans and mice.	FREM1 NID1	8.02e-05	4	128	2	21931569
Pubmed	Engagement of the T lymphocyte antigen receptor regulates association of son-of-sevenless homologues with the SH3 domain of phospholipase Cgamma1.	SOS1 SOS2	8.02e-05	4	128	2	10940929
Pubmed	Aldehyde dehydrogenase 1a1 is dispensable for stem cell function in the mouse hematopoietic and nervous systems.	ALDH1L1 ITGA2B ALDH4A1	8.17e-05	23	128	3	18971422
Pubmed	DUB-2 is a member of a novel family of cytokine-inducible deubiquitinating enzymes.	USP17L4 USP17L1 USP17L3	9.31e-05	24	128	3	8995226
Pubmed	Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury.	COL6A2 COL20A1 APOB NID1	9.37e-05	64	128	4	22261194
Pubmed	Interleukin 1 receptor signaling regulates DUBA expression and facilitates Toll-like receptor 9-driven antiinflammatory cytokine production.	USP17L4 USP17L1 USP17L3	1.06e-04	25	128	3	21115691
Pubmed	Identifying leukocyte gene expression patterns associated with plasma lipid levels in human subjects.	ITGA2B BMP1 FASN KIR2DS1	1.12e-04	67	128	4	16806233
Pubmed	Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.	DENND5B RASGRP4 SETD1B TRPM7 NACC1 TRUB2 GPR107 BMP1 FASN SMG7 PIK3CB USP7 EIF2AK4 PC SOS1	1.14e-04	1327	128	15	32694731
Pubmed	Decabromodiphenyl ethane affects embryonic development by interfering with nuclear F-actin in zygotes and leads to cognitive and social disorders in offspring mice.	USP17L4 USP17L1 USP17L3	1.19e-04	26	128	3	35816173
Pubmed	A critical function of the pial basement membrane in cortical histogenesis.	RELN NID1	1.33e-04	5	128	2	12122064
Pubmed	Mutation in Sos1 dominantly enhances a weak allele of the EGFR, demonstrating a requirement for Sos1 in EGFR signaling and development.	SOS1 SOS2	1.33e-04	5	128	2	9030684
Pubmed	The Axin/TNKS complex interacts with KIF3A and is required for insulin-stimulated GLUT4 translocation.	KIF3A TNKS	1.33e-04	5	128	2	22473005
Pubmed	Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy.	RPTOR ULK1	1.33e-04	5	128	2	19211835
Pubmed	Association of killer cell immunoglobulin-like receptor genotypes with vascular arterial events and anticardiolipin antibodies in patients with lupus.	KIR2DL1 KIR2DS1	1.33e-04	5	128	2	18755860
Pubmed	Monocilia in the embryonic mouse heart suggest a direct role for cilia in cardiac morphogenesis.	KIF3A DNAH11	1.33e-04	5	128	2	18729223
Pubmed	Diversity of the repertoire of p58 killer cell inhibitory receptors in a single individual.	KIR2DL1 KIR2DS1	1.33e-04	5	128	2	10424431
Pubmed	mRNA structure determines modification by pseudouridine synthase 1.	TRUB2 PUS7	1.33e-04	5	128	2	31477916
Pubmed	TRPM7 ion channels are required for sustained phosphoinositide 3-kinase signaling in lymphocytes.	TRPM7 PIK3CB	1.33e-04	5	128	2	18590694
Pubmed	The proline-rich tyrosine kinase Pyk2 regulates platelet integrin αIIbβ3 outside-in signaling.	ITGA2B PIK3CB	1.33e-04	5	128	2	23216754
Pubmed	Acetyl-CoA carboxylase 1 is a suppressor of the adipocyte thermogenic program.	MLYCD FASN	1.33e-04	5	128	2	37163372
Pubmed	Evidence that the KIR2DS5 gene codes for a surface receptor triggering natural killer cell function.	KIR2DL1 KIR2DS1	1.33e-04	5	128	2	18624290
GeneFamily	Guanylate cyclase receptors\|DENN/MADD domain containing	DENND5B NPR2 SBF2	1.99e-04	25	83	3	504
GeneFamily	Bone morphogenetic proteins\|Astacins	BMP1 TLL2	3.09e-04	6	83	2	894
GeneFamily	WD repeat domain containing	WDR76 PPWD1 WDFY4 RPTOR CFAP57 EIF3I	1.30e-03	262	83	6	362
Drug	Diphenidol hydrochloride [3254-89-5]; Down 200; 11.6uM; MCF7; HT_HG-U133A	ANKZF1 FBXO46 BMP1 PIK3CB HPS1 PRKCH PC NAGPA SOS2	1.07e-06	193	123	9	7447_DN
Drug	barium sulfate	ERCC2 ITGA2B DNAH11 SOS1 SOS2	3.46e-06	43	123	5	CID000024414
Drug	Betaxolol hydrochloride [63659-19-8]; Down 200; 11.6uM; MCF7; HT_HG-U133A	B3GNT4 EMC1 SNRK GPR107 BMP1 SMG7 ALDH4A1 PC	1.16e-05	196	123	8	5669_DN
Drug	beta- Belladonnine dichloroethylate [191355-47-2]; Down 200; 6uM; PC3; HT_HG-U133A	EMC1 SNRK WDR76 ME3 MLYCD BMP1 TBC1D4 ALDH4A1	1.16e-05	196	123	8	6638_DN
Drug	wortmannin from Penicillium funiculosum; Down 200; 0.01uM; MCF7; HT_HG-U133A	DENND5B B3GNT4 ALDH1L1 WDR76 BMP1 SMG7 USP7 PC	1.34e-05	200	123	8	5603_DN
Disease	primary ovarian insufficiency (implicated_via_orthology)	USP17L4 USP17L1 MOV10L1 USP17L3	4.10e-05	46	123	4	DOID:5426 (implicated_via_orthology)
Disease	Ovarian Serous Adenocarcinoma	TRPM7 SNRK MAP3K4	1.18e-04	23	123	3	C1335177
Disease	Immune System Diseases	TRPM7 EIF2AK4	3.57e-04	7	123	2	C0021053
Disease	marginal zone B-cell lymphoma	APOB PRKCH	4.75e-04	8	123	2	EFO_1000630
Disease	acquired immunodeficiency syndrome (is_implicated_in)	ERCC2 KIR2DL1	6.09e-04	9	123	2	DOID:635 (is_implicated_in)
Disease	pregnenetriol sulfate measurement	PUDP UGT1A10	9.25e-04	11	123	2	EFO_0800586
Disease	asthma exacerbation measurement, response to corticosteroid	TNIK ME3 DNAH11	1.27e-03	51	123	3	EFO_0007614, GO_0031960
Disease	pregnenetriol disulfate measurement	PUDP UGT1A10	1.30e-03	13	123	2	EFO_0800587
Disease	orotic acid measurement	LINC00269 DNAH11	1.52e-03	14	123	2	EFO_0010516
Disease	age at first birth measurement	CACNA1A FREM1 MST1R TNKS	1.63e-03	120	123	4	EFO_0009101
Disease	Noonan-Like Syndrome With Loose Anagen Hair	SOS1 SOS2	2.81e-03	19	123	2	C3501846
Disease	Noonan syndrome-like disorder with loose anagen hair	SOS1 SOS2	2.81e-03	19	123	2	C1843181
Disease	cerebral infarction (is_marker_for)	APOB SOS1	2.81e-03	19	123	2	DOID:3526 (is_marker_for)
Disease	Cardio-facio-cutaneous syndrome	SOS1 SOS2	2.81e-03	19	123	2	C1275081
Disease	Costello syndrome (disorder)	SOS1 SOS2	2.81e-03	19	123	2	C0587248
Disease	aggressive behaviour measurement, ADHD symptom measurement	XYLT1 MST1R RPTOR	2.91e-03	68	123	3	EFO_0007826, EFO_0007860
Disease	congenital heart disease (implicated_via_orthology)	USP17L4 USP17L1 USP17L3	3.03e-03	69	123	3	DOID:1682 (implicated_via_orthology)
Disease	LEOPARD Syndrome	SOS1 SOS2	3.77e-03	22	123	2	C0175704
Disease	Down syndrome (is_marker_for)	RELN ERCC2	3.77e-03	22	123	2	DOID:14250 (is_marker_for)
Disease	intellectual disability (implicated_via_orthology)	NDST2 ITGA2B PUS7	3.84e-03	75	123	3	DOID:1059 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
GALSDILHVEFRKGH	TDRD5	346	Q8NAT2
LIFVFLVETGFHHVG	nan	36	Q8N976
FEAGIKIIALGFAFH	CACNA1A	146	O00555
SVKVRSHVGHTGVFF	AGPAT4-IT1	96	Q9H0P7
HYITVVAKDGGGRLH	CDHR1	206	Q96JP9
HHTRLIFVFSVETGF	LINC00269	116	Q8N2A0
IFVFSVETGFHHVGQ	LINC00269	121	Q8N2A0
HVKIGDFGLATDHLA	EIF2AK4	861	Q9P2K8
DGAIKHANFHFRTEG	CASZ1	1046	Q86V15
GHEGEILQFHVIRTF	ADGRV1	2716	Q8WXG9
HVQRLFGFHSDLIKV	ADGRV1	5026	Q8WXG9
KVHVGDEDFVHLRVF	CSTB	56	P04080
KAVTTDELFGFIHHA	DNAH11	2206	Q96DT5
GGKNFHFVHRSADVE	ALDH4A1	316	P30038
APKLGEFVVTLHGHF	NPR2	146	P20594
GSSFFEKHHVSVRLG	DNHD1	1786	Q96M86
IHHSGEKGDIVVFLA	DHX32	266	Q7L7V1
DKFGIVVHELGHVVG	BMP1	206	P13497
HFGSIHDAVRAGDVK	ANKRD42	26	Q8N9B4
RHKVHLNTFGFFKDG	GPR107	51	Q5VW38
RVGHFTHVFVDEAGQ	MOV10L1	876	Q9BXT6
TLQVFVRKHGAHGAA	NPNT	496	Q6UXI9
HFHKTAFLGQRGLVE	SBF2	386	Q86WG5
RHKEFFSLFSHIVLG	PUDP	126	Q08623
SGHFIVVGFADKLRL	CFAP57	441	Q96MR6
KHEVIHALGFSAGLF	LMLN	271	Q96KR4
FHHISKLDGGVRFLV	MLYCD	141	O95822
AGAGHFEVVKLLVSH	FEM1B	96	Q9UK73
VLHAFDEFLGIRHSK	IDO2	286	Q6ZQW0
KEHVNVVFIGHVDAG	GSPT2	201	Q8IYD1
HHFKGIIEAFGVRAT	FBXO46	501	Q6PJ61
STGKFAFPGHREIHV	LCN8	91	Q6JVE9
GSSILERHHLEFGKF	PDE6B	621	P35913
LVIKQRFSGIDEHGH	NID1	531	P14543
HTFLRNGGHFVISIK	FBL	251	P22087
TKDFVVFRIFDGHHS	FREM1	491	Q5H8C1
VFRIFDGHHSIRHKF	FREM1	496	Q5H8C1
GLAFLHTFHEVTFRK	RASGRP4	536	Q8TDF6
RGKVSEGIDFVHHYG	ERCC2	601	P18074
HVSAKVGTRLVFDHY	PMS2P1	326	A4D2B8
HTILVEFFLKGLSGH	OR13C5	6	Q8NGS8
HTILVEFFLKGLSGH	OR13C2	6	Q8NGS9
SFAHIFGHIAKAEGD	KIF3A	126	Q9Y496
KHLQEGRALHFGEFL	MROH1	1536	Q8NDA8
VVHFGKLHLCGSVRF	RELN	2091	P78509
DHEFVAKGHLFRKGI	MED18	126	Q9BUE0
GKHFVGEKRFESIHD	CHN2	111	P52757
EFTGRHDAHLNGKVI	APOB	3016	P04114
ARRIILGTHHEKGAF	HIP1R	51	O75146
HHAGFKTFGIRRPLD	B3GNT4	321	Q9C0J1
HFAGAIFQGREVVTH	ANKZF1	216	Q9H8Y5
EVRKIFFGSFHKVHV	COL20A1	961	Q9P218
FFGSFHKVHVAVGRS	COL20A1	966	Q9P218
HLAFEEEFGRVKGHF	EIF3I	271	Q13347
KGTVHFAVVITDGHV	COL6A2	151	P12110
TFFVATGFHGLHVII	MT-CO3	196	P00414
KGFVRTALQHGAHLV	AWAT1	201	Q58HT5
GLVAALEQVFHHGFK	DENND5B	1126	Q6ZUT9
LEQVFHHGFKSARIF	DENND5B	1131	Q6ZUT9
IHAGVKVVFSGHYHR	CPPED1	236	Q9BRF8
GHEFIVKREHALTSG	ELOC	26	Q15369
FGGHHELIEYVIAKG	AMDHD1	406	Q96NU7
KGFRDSTGLLHHQVV	FIZ1	86	Q96SL8
RGLFITIHDKGHLAT	ME3	156	Q16798
FRHKVTGVEYHNAGT	IQUB	256	Q8NA54
HHERTFIGIFLIDGV	EMC1	751	Q8N766
GAFHLIVHLKAGDAV	EMILIN2	1006	Q9BXX0
HFDHIRAVIGSEFIG	DPEP3	341	Q9H4B8
GKHFVGEKRFESIHD	CHN1	101	P15882
FEKIHRSLAHVFQGE	FAM83H	251	Q6ZRV2
KVVEVLAGHGHLYSR	FASN	1241	P49327
FEVHFGLVTVDGHLI	HPS1	116	Q92902
VVQHVHFDGLGRTKD	SAMM50	46	Q9Y512
RLIGEHHDGVSKANF	KIR2DL1	71	P43626
FAEHSVRKRGHIDFI	ECSIT	96	Q9BQ95
HHILSGKEFGVERSV	PHKA2	956	P46019
EHGFRVHGKNFHLIQ	MIER2	311	Q8N344
RLIGEHHDGVSKANF	KIR2DS1	71	Q14954
GFSRFHKHHITLFVV	OR10J6P	16	Q8NGY7
EHGIVHRDIKGANIF	MAP3K4	1456	Q9Y6R4
FHCFRKAIHEVFEVG	RRAGC	356	Q9HB90
HVLLGTFEKHTDGTF	RNF157	216	Q96PX1
IGAKHERHIFLFDGL	SOS2	451	Q07890
EGIEFVKHFRSHLGV	PPWD1	121	Q96BP3
VSDFIKAFIKFHGHV	SMG7	246	Q92540
TAIGHDRKGQLVLFH	NAGPA	241	Q9UK23
DFVVHEIGKDGRISH	PUS7	136	Q96PZ0
FATVRGAKDAVQHLH	SETD1B	151	Q9UPS6
KGRAEAHFSLIHYAG	MYH3	571	P11055
FKLVSVHVFIRHGDR	PXYLP1	86	Q8TE99
IVAGHGKSHVFNVEL	SNTG2	391	Q9NY99
KHVRAPEFATHGVAA	SLC25A52	111	Q3SY17
GFSLDFHKDSHGRVA	ITGA2B	51	P08514
FHKDSHGRVAIVVGA	ITGA2B	56	P08514
EETVKVHVRAGLFHG	PIK3CB	346	P42338
AEGHIIHIDFGFILS	PI4KB	681	Q9UBF8
TRVGAKHERHIFLFD	SOS1	451	Q07889
GVVGFHESLSHELKA	RDH10	216	Q8IZV5
TLGRGHFAVVKLARH	SNRK	21	Q9NRH2
HFAVVKLARHVFTGE	SNRK	26	Q9NRH2
AKEERVLFHYNGHGV	RPTOR	141	Q8N122
YCHLRKEGHEVVGVF	ALDH1L1	16	O75891
VGGTFDRLHNAHKVL	COASY	196	Q13057
ARHQLDHVFKIGIGE	CLUH	801	O75153
FLQEKHLFHGDVAAR	STYK1	241	Q6J9G0
SGFHRGKQEDVHEFL	USP17L3	151	A6NCW0
KVIFGSHTGFHVIDV	TNIK	1206	Q9UKE5
LADRFQGFLIKHHAT	XYLT1	691	Q86Y38
ALHFAAREGHAKAVA	TRPA1	551	O75762
VVFTRGIFCHHLEEG	UGT1A10	166	Q9HAW8
AGFHRGKQEDVHEFL	USP17L4	151	A6NCW7
KLRGEFDGSVTFHHP	RMC1	291	Q96DM3
HFAAGFGRKDVVEHL	TNKS	221	O95271
AIIHKGFDERHAYIG	TNKS	1191	O95271
LEGFKFHHEASGVTV	WDFY4	366	Q6ZS81
RGVHHAFAKILAEGG	SLC25A27	171	O95847
KFGIVAHELGHVVGF	TLL2	236	Q9Y6L7
VGIIGFFRAHEHSLL	NDST2	166	P52849
TKTFDVEHSHVRFLG	RRAGB	101	Q5VZM2
TKIFITHLHGDHFFG	ELAC1	56	Q9H777
AGFHRGKQEDVHEFL	USP17L1	151	Q7RTZ2
GIKHVDHFGFICRES	TBC1D4	391	O60343
IFHETGKRVHSFGGE	WDR76	576	Q9H967
GFRVHQRVHTGEKPF	ZNF418	496	Q8TF45
FHILVDAGRSHGAIK	TSPYL6	71	Q8N831
FAHLKVGVGHRLDAQ	TRUB2	86	O95900
GVFKHALTSLGYHRV	THSD4	416	Q6ZMP0
AKHFLQDSFHRGGVV	VRTN	316	Q9H8Y1
TVAHFHKEVFGTFGI	USP7	991	Q93009
FGHIRVYFGHLKEVH	ZNF438	576	Q7Z4V0
NAGTVEFLVDRHGKH	PC	306	P11498
VTHSDRVIGKGHFGV	MST1R	1081	Q04912
LHSHFILVDDGTVGK	TRPM7	241	Q96QT4
FSRKDLIGHGAFAVV	ULK1	16	O75385
LIGHGAFAVVFKGRH	ULK1	21	O75385
AFAVVFKGRHREKHD	ULK1	26	O75385
ERFHVELHFSPGVKG	PPIP5K1	901	Q6PFW1
HKFHVGVGSLVQETL	PPIP5K1	1351	Q6PFW1
SERGKAFHQGLHFTI	ZNF83	96	P51522
TQGGEHAILRHPFFK	PRKCH	601	P24723
VKGHAFKAHRAVLAA	NACC1	36	Q96RE7