Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionsolute:sodium symporter activity

SLC6A7 SLC6A5 SLC5A7 SLC5A9 SLC6A14 SLC17A6

5.75e-0881516GO:0015370
GeneOntologyMolecularFunctionsolute:monoatomic cation symporter activity

SLC6A7 SLC6A5 SLC5A7 SLC5A9 SLC6A14 SLC17A6

5.71e-07119516GO:0015294
GeneOntologyMolecularFunctionsymporter activity

SLC6A7 SLC6A5 SLC5A7 SLC5A9 SLC6A14 SLC17A6

2.22e-06150516GO:0015293
GeneOntologyMolecularFunctionsodium ion transmembrane transporter activity

SLC6A7 SLC6A5 SLC5A7 SLC5A9 SLC6A14 SLC17A6

4.73e-06171516GO:0015081
GeneOntologyMolecularFunctionactive transmembrane transporter activity

SLC6A7 ABCA2 SLC6A5 SLC5A7 SLC5A9 BCS1L SLC6A14 SLC17A6

2.58e-05477518GO:0022804
GeneOntologyMolecularFunctionamino acid:sodium symporter activity

SLC6A7 SLC6A5 SLC6A14

2.68e-0523513GO:0005283
GeneOntologyMolecularFunctionsialic acid binding

MAG SIGLEC9 SIGLEC8

3.47e-0525513GO:0033691
GeneOntologyMolecularFunctionextracellular matrix binding

OLFML2A ACHE C6orf15 ITGA6

3.61e-0573514GO:0050840
GeneOntologyMolecularFunctionamino acid:monoatomic cation symporter activity

SLC6A7 SLC6A5 SLC6A14

5.47e-0529513GO:0005416
GeneOntologyMolecularFunctionorganic cation transmembrane transporter activity

SLC6A7 SLC6A5 SLC5A7 SLC6A14

5.98e-0583514GO:0015101
GeneOntologyMolecularFunctiondolichyl-diphosphooligosaccharide-protein glycotransferase activity

RPN1 STT3A

6.36e-055512GO:0004579
GeneOntologyMolecularFunctionoligosaccharyl transferase activity

RPN1 STT3A

6.36e-055512GO:0004576
GeneOntologyMolecularFunctionlaminin binding

ACHE C6orf15 ITGA6

8.88e-0534513GO:0043236
GeneOntologyMolecularFunctionorganic acid:sodium symporter activity

SLC6A7 SLC6A5 SLC6A14

9.70e-0535513GO:0005343
GeneOntologyMolecularFunctionsecondary active transmembrane transporter activity

SLC6A7 SLC6A5 SLC5A7 SLC5A9 SLC6A14 SLC17A6

1.04e-04296516GO:0015291
GeneOntologyMolecularFunctionactive monoatomic ion transmembrane transporter activity

SLC6A7 SLC6A5 SLC5A7 SLC5A9 SLC6A14 SLC17A6

1.14e-04301516GO:0022853
GeneOntologyMolecularFunctioncholine binding

ACHE SLC5A7

1.33e-047512GO:0033265
GeneOntologyMolecularFunctionamino acid transmembrane transporter activity

SLC6A7 SLC6A5 SLC6A14 SLC17A6

1.49e-04105514GO:0015171
GeneOntologyMolecularFunctionneutral L-amino acid transmembrane transporter activity

SLC6A7 SLC6A5 SLC6A14

1.56e-0441513GO:0015175
GeneOntologyMolecularFunctiontransmembrane transporter activity

SLC6A7 ABCA2 SLC50A1 SLC6A5 SLC5A7 SLC5A9 BCS1L SLC33A1 SLC6A14 RYR3 SLC17A6

1.57e-0411805111GO:0022857
GeneOntologyMolecularFunctionmetal ion transmembrane transporter activity

SLC6A7 SLC6A5 SLC5A7 SLC5A9 SLC6A14 RYR3 SLC17A6

1.69e-04465517GO:0046873
GeneOntologyMolecularFunctiontransporter activity

SLC6A7 ABCA2 SLC50A1 SLC6A5 SLC5A7 SLC5A9 BCS1L SLC33A1 SLC6A14 RYR3 SLC17A6

3.37e-0412895111GO:0005215
GeneOntologyMolecularFunctionL-amino acid transmembrane transporter activity

SLC6A7 SLC6A5 SLC17A6

7.94e-0471513GO:0015179
GeneOntologyMolecularFunctionorganic anion transmembrane transporter activity

SLC6A7 SLC6A5 SLC33A1 SLC6A14 SLC17A6

8.89e-04293515GO:0008514
GeneOntologyMolecularFunctioninorganic cation transmembrane transporter activity

SLC6A7 SLC6A5 SLC5A7 SLC5A9 SLC6A14 RYR3 SLC17A6

1.01e-03627517GO:0022890
GeneOntologyMolecularFunctionmonoatomic cation transmembrane transporter activity

SLC6A7 SLC6A5 SLC5A7 SLC5A9 SLC6A14 RYR3 SLC17A6

1.41e-03664517GO:0008324
GeneOntologyMolecularFunctionhistone H4 acetyltransferase activity

NAA60 BRD1

1.56e-0323512GO:0010485
GeneOntologyMolecularFunctioncarboxylic acid transmembrane transporter activity

SLC6A7 SLC6A5 SLC6A14 SLC17A6

1.92e-03207514GO:0046943
GeneOntologyMolecularFunctionorganic acid transmembrane transporter activity

SLC6A7 SLC6A5 SLC6A14 SLC17A6

1.95e-03208514GO:0005342
GeneOntologyMolecularFunctionsugar transmembrane transporter activity

SLC50A1 SLC5A9

2.48e-0329512GO:0051119
GeneOntologyMolecularFunctioninorganic molecular entity transmembrane transporter activity

SLC6A7 SLC6A5 SLC5A7 SLC5A9 SLC6A14 RYR3 SLC17A6

2.99e-03758517GO:0015318
GeneOntologyMolecularFunctionmonoatomic ion transmembrane transporter activity

SLC6A7 SLC6A5 SLC5A7 SLC5A9 SLC6A14 RYR3 SLC17A6

3.83e-03793517GO:0015075
GeneOntologyMolecularFunctioncarbohydrate transmembrane transporter activity

SLC50A1 SLC5A9

5.16e-0342512GO:0015144
GeneOntologyMolecularFunctionhistone acetyltransferase activity

NAA60 BRD1

7.53e-0351512GO:0004402
GeneOntologyMolecularFunctioncarbohydrate binding

MAG SIGLEC9 SIGLEC8 GALNT7

8.03e-03310514GO:0030246
GeneOntologyMolecularFunctionpeptide-lysine-N-acetyltransferase activity

NAA60 BRD1

8.71e-0355512GO:0061733
GeneOntologyMolecularFunctioncarbohydrate derivative transmembrane transporter activity

SLC50A1 SLC33A1

9.97e-0359512GO:1901505
GeneOntologyMolecularFunctionpeptide N-acetyltransferase activity

NAA60 BRD1

1.03e-0260512GO:0034212
GeneOntologyBiologicalProcessnegative regulation of phagocytosis, engulfment

SIGLEC9 SIGLEC8

6.95e-055552GO:0060101
GeneOntologyBiologicalProcesssodium ion transport

SLC6A7 SLC6A5 SLC5A7 SLC5A9 SLC6A14 SLC17A6

8.91e-05275556GO:0006814
GeneOntologyBiologicalProcessnegative regulation of membrane invagination

SIGLEC9 SIGLEC8

1.04e-046552GO:1905154
GeneOntologyBiologicalProcessglycoprotein metabolic process

ABCA2 RPN1 FBXO44 GLCE IHH GALNT7 STT3A

1.40e-04430557GO:0009100
GeneOntologyBiologicalProcessacetylcholine metabolic process

ACHE SLC5A7

1.93e-048552GO:0008291
GeneOntologyBiologicalProcessacetate ester metabolic process

ACHE SLC5A7

1.93e-048552GO:1900619
GeneOntologyBiologicalProcesssodium ion transmembrane transport

SLC6A7 SLC6A5 SLC5A9 SLC6A14 SLC17A6

2.30e-04208555GO:0035725
GeneOntologyBiologicalProcesscentral nervous system myelin formation

MAG ABCA2

2.48e-049552GO:0032289
GeneOntologyBiologicalProcessamino acid transmembrane transport

SLC6A7 SLC6A5 SLC6A14 SLC17A6

2.96e-04120554GO:0003333
GeneOntologyBiologicalProcesspositive regulation of miRNA-mediated gene silencing

TIAL1 PUM1

4.53e-0412552GO:2000637
GeneOntologyBiologicalProcessamino acid import across plasma membrane

SLC6A7 SLC6A5 SLC6A14

4.99e-0458553GO:0089718
GeneOntologyBiologicalProcesspositive regulation of post-transcriptional gene silencing by RNA

TIAL1 PUM1

5.34e-0413552GO:1900370
GeneOntologyBiologicalProcesspositive regulation of post-transcriptional gene silencing

TIAL1 PUM1

5.34e-0413552GO:0060148
GeneOntologyBiologicalProcessneutral amino acid transport

SLC6A7 SLC6A5 SLC6A14

5.51e-0460553GO:0015804
DomainNA_NEUROTRAN_SYMP_2

SLC6A7 SLC6A5 SLC6A14

1.35e-0518493PS00754
DomainNA_NEUROTRAN_SYMP_3

SLC6A7 SLC6A5 SLC6A14

1.60e-0519493PS50267
DomainSNF

SLC6A7 SLC6A5 SLC6A14

1.60e-0519493PF00209
DomainNa/ntran_symport

SLC6A7 SLC6A5 SLC6A14

1.60e-0519493IPR000175
DomainNA_NEUROTRAN_SYMP_1

SLC6A7 SLC6A5 SLC6A14

1.60e-0519493PS00610
DomainSAPAP

DLGAP2 DLGAP3

6.71e-055492IPR005026
DomainGKAP

DLGAP2 DLGAP3

6.71e-055492PF03359
DomainC2-set_2

MAG SIGLEC9 SIGLEC8

1.69e-0441493PF08205
DomainCD80_C2-set

MAG SIGLEC9 SIGLEC8

1.69e-0441493IPR013162
DomainNA_SOLUT_SYMP_1

SLC5A7 SLC5A9

3.65e-0411492PS00456
DomainNA_SOLUT_SYMP_2

SLC5A7 SLC5A9

4.38e-0412492PS00457
DomainSSF

SLC5A7 SLC5A9

4.38e-0412492PF00474
DomainNa/solute_symporter

SLC5A7 SLC5A9

4.38e-0412492IPR001734
DomainNA_SOLUT_SYMP_3

SLC5A7 SLC5A9

4.38e-0412492PS50283
DomainInt_alpha_beta-p

GPLD1 ITGA6

1.12e-0319492IPR013519
DomainInt_alpha

GPLD1 ITGA6

1.12e-0319492SM00191
DomainV-set

MAG VPREB1 SIGLEC9 SIGLEC8

1.37e-03184494PF07686
DomainFG_GAP

GPLD1 ITGA6

1.51e-0322492PS51470
DomainFG-GAP

GPLD1 ITGA6

1.79e-0324492PF01839
DomainFG-GAP

GPLD1 ITGA6

1.79e-0324492IPR013517
DomainIg_V-set

MAG VPREB1 SIGLEC9 SIGLEC8

1.82e-03199494IPR013106
PathwayREACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT

SLC6A7 SLC50A1 SLC6A5 SLC5A7 SLC5A9 SLC33A1 SLC6A14 SLC17A6

2.30e-07238398MM15076
PathwayREACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT

SLC6A7 SLC50A1 SLC6A5 SLC5A7 SLC5A9 SLC33A1 SLC6A14 SLC17A6

3.25e-07249398M5988
PathwayREACTOME_TRANSPORT_OF_SMALL_MOLECULES

SLC6A7 ABCA2 SLC50A1 SLC6A5 SLC5A7 SLC5A9 SLC33A1 SLC6A14 RYR3 SLC17A6

1.15e-056813910MM14985
PathwayREACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS

SLC6A7 SLC6A5 SLC6A14

1.84e-0519393MM15107
PathwayREACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS

SLC6A7 SLC6A5 SLC6A14

1.84e-0519393M27362
PathwayREACTOME_TRANSPORT_OF_SMALL_MOLECULES

SLC6A7 ABCA2 SLC50A1 SLC6A5 SLC5A7 SLC5A9 SLC33A1 SLC6A14 RYR3 SLC17A6

2.26e-057363910M27287
PathwayWP_NRF2_PATHWAY

SLC6A7 SLC6A5 SLC5A7 SLC5A9 SLC6A14

4.08e-05141395M39454
PathwayREACTOME_TRANSPORT_OF_BILE_SALTS_AND_ORGANIC_ACIDS_METAL_IONS_AND_AMINE_COMPOUNDS

SLC6A7 SLC6A5 SLC5A7 SLC6A14

5.56e-0576394MM15072
PathwayREACTOME_TRANSPORT_OF_BILE_SALTS_AND_ORGANIC_ACIDS_METAL_IONS_AND_AMINE_COMPOUNDS

SLC6A7 SLC6A5 SLC5A7 SLC6A14

8.23e-0584394M27334
PathwayREACTOME_SLC_TRANSPORTER_DISORDERS

SLC6A5 SLC5A7 SLC33A1 SLC6A14

1.56e-0499394M27474
PathwayKEGG_MEDICUS_REFERENCE_N_GLYCAN_PRECURSOR_BIOSYNTHESIS_ALG6_TO_OST

RPN1 STT3A

4.04e-0411392M47614
PathwayWP_CELL_LINEAGE_MAP_FOR_NEURONAL_DIFFERENTIATION

ACHE SLC6A5 ITGA6 SLC17A6

4.69e-04132394M48110
PathwayREACTOME_CELLULAR_HEXOSE_TRANSPORT

SLC50A1 SLC5A9

1.24e-0319392MM14718
PathwayREACTOME_DISORDERS_OF_TRANSMEMBRANE_TRANSPORTERS

SLC6A5 SLC5A7 SLC33A1 SLC6A14

1.40e-03177394M27476
PathwayREACTOME_CELLULAR_HEXOSE_TRANSPORT

SLC50A1 SLC5A9

1.52e-0321392M27058
PathwayWP_NUCLEAR_RECEPTORS_METAPATHWAY

SLC6A7 SLC6A5 SLC5A7 SLC5A9 SLC6A14

1.64e-03314395M39428
PathwayREACTOME_CELL_SURFACE_INTERACTIONS_AT_THE_VASCULAR_WALL

MAG VPREB1 IGLV1-40 ITGA6

1.96e-03194394M16312
PathwayREACTOME_BASIGIN_INTERACTIONS

MAG ITGA6

1.98e-0324392MM17215
PathwayREACTOME_BASIGIN_INTERACTIONS

MAG ITGA6

2.15e-0325392M4974
Pubmed

Natural anti-Siglec autoantibodies mediate potential immunoregulatory mechanisms: implications for the clinical use of intravenous immunoglobulins (IVIg).

SIGLEC9 SIGLEC8

2.46e-06255218558361
Pubmed

Regulation of airway inflammation by Siglec-8 and Siglec-9 sialoglycan ligand expression.

SIGLEC9 SIGLEC8

2.46e-06255226694037
Pubmed

Expression of ligands for Siglec-8 and Siglec-9 in human airways and airway cells.

SIGLEC9 SIGLEC8

2.46e-06255225747723
Pubmed

The repertoire of solute carriers of family 6: identification of new human and rodent genes.

SLC6A7 SLC6A5 SLC6A14

4.88e-062155316125675
Pubmed

Cotranslational and posttranslational N-glycosylation of polypeptides by distinct mammalian OST isoforms.

RPN1 STT3A

7.36e-06355219167329
Pubmed

Immunosuppressive Siglec-E ligands on mouse aorta are up-regulated by LPS via NF-κB pathway.

SIGLEC9 SIGLEC8

1.47e-05455231918287
Pubmed

Studies on the Detection, Expression, Glycosylation, Dimerization, and Ligand Binding Properties of Mouse Siglec-E.

SIGLEC9 SIGLEC8

1.47e-05455227920204
Pubmed

Early murine T-lymphocyte activation is accompanied by a switch from N-Glycolyl- to N-acetyl-neuraminic acid and generation of ligands for siglec-E.

SIGLEC9 SIGLEC8

1.47e-05455221835922
Pubmed

Sialylated ligands on pathogenic Trypanosoma cruzi interact with Siglec-E (sialic acid-binding Ig-like lectin-E).

SIGLEC9 SIGLEC8

1.47e-05455219552697
Pubmed

Targeting the Siglec-sialic acid axis promotes antitumor immune responses in preclinical models of glioblastoma.

SIGLEC9 SIGLEC8

1.47e-05455237467314
Pubmed

Polysialic acid promotes remyelination in cerebellar slice cultures by Siglec-E-dependent modulation of microglia polarization.

SIGLEC9 SIGLEC8

1.47e-05455237492129
Pubmed

Ablation of Siglec-E augments brain inflammation and ischemic injury.

SIGLEC9 SIGLEC8

1.47e-05455235858866
Pubmed

Human-specific elimination of epithelial Siglec-XII suppresses the risk of inflammation-driven colorectal cancers.

SIGLEC9 SIGLEC8

1.47e-05455238990656
Pubmed

Molecular characterization of the human immunoglobulin V lambda I germline gene repertoire.

IGLV1-50 IGLV1-40

1.47e-0545521495496
Pubmed

Siglecs-7/9 function as inhibitory immune checkpoints in vivo and can be targeted to enhance therapeutic antitumor immunity.

SIGLEC9 SIGLEC8

1.47e-05455234155121
Pubmed

Polysialic acid and Siglec-E orchestrate negative feedback regulation of microglia activation.

SIGLEC9 SIGLEC8

1.47e-05455232725371
Pubmed

The human sialic acid-binding immunoglobulin-like lectin Siglec-9 and its murine homolog Siglec-E control osteoclast activity and bone resorption.

SIGLEC9 SIGLEC8

1.47e-05455233007530
Pubmed

Involvement of sulfates from cruzipain, a major antigen of Trypanosoma cruzi, in the interaction with immunomodulatory molecule Siglec-E.

SIGLEC9 SIGLEC8

1.47e-05455226047932
Pubmed

Leishmania donovani Utilize Sialic Acids for Binding and Phagocytosis in the Macrophages through Selective Utilization of Siglecs and Impair the Innate Immune Arm.

SIGLEC9 SIGLEC8

1.47e-05455227494323
Pubmed

Siglec-9 acts as an immune-checkpoint molecule on macrophages in glioblastoma, restricting T-cell priming and immunotherapy response.

SIGLEC9 SIGLEC8

1.47e-05455237460871
Pubmed

Siglec genes confer resistance to systemic lupus erythematosus in humans and mice.

SIGLEC9 SIGLEC8

1.47e-05455229503442
Pubmed

Group B Streptococcus engages an inhibitory Siglec through sialic acid mimicry to blunt innate immune and inflammatory responses in vivo.

SIGLEC9 SIGLEC8

1.47e-05455224391502
Pubmed

Engagement of myelomonocytic Siglecs by tumor-associated ligands modulates the innate immune response to cancer.

SIGLEC9 SIGLEC8

1.47e-05455225225409
Pubmed

The receptor binding domain of SARS-CoV-2 Omicron subvariants targets Siglec-9 to decrease its immunogenicity by preventing macrophage phagocytosis.

SIGLEC9 SIGLEC8

1.47e-05455238454157
Pubmed

Self-associated molecular patterns mediate cancer immune evasion by engaging Siglecs on T cells.

SIGLEC9 SIGLEC8

1.47e-05455230130255
Pubmed

Dual actions of group B Streptococcus capsular sialic acid provide resistance to platelet-mediated antimicrobial killing.

SIGLEC9 SIGLEC8

1.47e-05455230910970
Pubmed

O-Acetylation of Capsular Polysialic Acid Enables Escherichia coli K1 Escaping from Siglec-Mediated Innate Immunity and Lysosomal Degradation of E. coli-Containing Vacuoles in Macrophage-Like Cells.

SIGLEC9 SIGLEC8

1.47e-05455234878295
Pubmed

Siglec receptors impact mammalian lifespan by modulating oxidative stress.

SIGLEC9 SIGLEC8

1.47e-05455225846707
Pubmed

Siglec-E promotes β2-integrin-dependent NADPH oxidase activation to suppress neutrophil recruitment to the lung.

SIGLEC9 SIGLEC8

2.45e-05555224895121
Pubmed

Microglial CD33-related Siglec-E inhibits neurotoxicity by preventing the phagocytosis-associated oxidative burst.

SIGLEC9 SIGLEC8

2.45e-05555224227736
Pubmed

Differential mRNA expression and protein localization of the SAP90/PSD-95-associated proteins (SAPAPs) in the nervous system of the mouse.

DLGAP2 DLGAP3

2.45e-05555215024750
Pubmed

Probing the cis interactions of the inhibitory receptor Siglec-7 with alpha2,8-disialylated ligands on natural killer cells and other leukocytes using glycan-specific antibodies and by analysis of alpha2,8-sialyltransferase gene expression.

SIGLEC9 SIGLEC8

2.45e-05555216857734
Pubmed

A soluble form of Siglec-9 provides an antitumor benefit against mammary tumor cells expressing MUC1 in transgenic mice.

SIGLEC9 SIGLEC8

2.45e-05555224924635
Pubmed

Binding of the sialic acid-binding lectin, Siglec-9, to the membrane mucin, MUC1, induces recruitment of β-catenin and subsequent cell growth.

SIGLEC9 SIGLEC8

2.45e-05555224045940
Pubmed

Siglec-E is up-regulated and phosphorylated following lipopolysaccharide stimulation in order to limit TLR-driven cytokine production.

SIGLEC9 SIGLEC8

2.45e-05555219933851
Pubmed

Siglec-9 modulated IL-4 responses in the macrophage cell line RAW264.

SIGLEC9 SIGLEC8

2.45e-05555226540411
Pubmed

The prognostic impact of SIGLEC5-induced impairment of CD8+ T cell activation in sepsis.

SIGLEC9 SIGLEC8

2.45e-05555237890368
Pubmed

Siglec-E Negatively Regulates the Activation of TLR4 by Controlling Its Endocytosis.

SIGLEC9 SIGLEC8

2.45e-05555227619995
Pubmed

One-megabase sequence analysis of the human immunoglobulin lambda gene locus.

VPREB1 IGLV1-50 IGLV1-40 IGLV7-46

2.75e-051095549074928
Pubmed

Siglec-E is a negative regulator of acute pulmonary neutrophil inflammation and suppresses CD11b β2-integrin-dependent signaling.

SIGLEC9 SIGLEC8

3.67e-05655223315163
Pubmed

Molecular cloning of MIS, a myeloid inhibitory siglec, that binds protein-tyrosine phosphatases SHP-1 and SHP-2.

SIGLEC9 SIGLEC8

3.67e-05655211278955
Pubmed

OST4 is a subunit of the mammalian oligosaccharyltransferase required for efficient N-glycosylation.

RPN1 STT3A

3.67e-05655223606741
Pubmed

Oligosaccharyltransferase isoforms that contain different catalytic STT3 subunits have distinct enzymatic properties.

RPN1 STT3A

3.67e-05655212887896
Pubmed

mSiglec-E, a novel mouse CD33-related siglec (sialic acid-binding immunoglobulin-like lectin) that recruits Src homology 2 (SH2)-domain-containing protein tyrosine phosphatases SHP-1 and SHP-2.

SIGLEC9 SIGLEC8

5.13e-05755211171044
Pubmed

[Functions and molecular evolution of Siglecs, a family of sialic acid receptor proteins].

SIGLEC9 SIGLEC8

5.13e-05755218453149
Pubmed

Paired Siglec receptors generate opposite inflammatory responses to a human-specific pathogen.

SIGLEC9 SIGLEC8

5.13e-05755228100677
Pubmed

The novel gene encoding a putative transmembrane protein is mutated in gnathodiaphyseal dysplasia (GDD).

SLC6A5 SLC17A6

5.13e-05755215124103
Pubmed

The interaction between maternal immune activation and alpha 7 nicotinic acetylcholine receptor in regulating behaviors in the offspring.

ACHE SLC5A7

5.13e-05755225683697
Pubmed

The murine inhibitory receptor mSiglec-E is expressed broadly on cells of the innate immune system whereas mSiglec-F is restricted to eosinophils.

SIGLEC9 SIGLEC8

5.13e-05755215048729
Pubmed

PNPLA3 variants specifically confer increased risk for histologic nonalcoholic fatty liver disease but not metabolic disease.

GPLD1 JMJD1C

5.13e-05755220648472
Pubmed

SAPAPs. A family of PSD-95/SAP90-associated proteins localized at postsynaptic density.

DLGAP2 DLGAP3

5.13e-0575529115257
Pubmed

Endochondral Ossification Is Accelerated in Cholinesterase-Deficient Mice and in Avian Mesenchymal Micromass Cultures.

ACHE IHH

5.13e-05755228118357
Pubmed

Proline-rich synapse-associated proteins ProSAP1 and ProSAP2 interact with synaptic proteins of the SAPAP/GKAP family.

DLGAP2 DLGAP3

5.13e-05755210527873
Pubmed

Fragile X mental retardation protein regulates the levels of scaffold proteins and glutamate receptors in postsynaptic densities.

DLGAP2 DLGAP3

6.83e-05855219640847
Pubmed

Broad and direct interaction between TLR and Siglec families of pattern recognition receptors and its regulation by Neu1.

SIGLEC9 SIGLEC8

6.83e-05855225187624
Pubmed

Spinal Hb9::Cre-derived excitatory interneurons contribute to rhythm generation in the mouse.

SLC6A5 SLC17A6

8.78e-05955228128321
Pubmed

Mafa-dependent GABAergic activity promotes mouse neonatal apneas.

SLC6A5 SLC17A6

8.78e-05955235672398
Pubmed

Lectin galactoside-binding soluble 3 binding protein (LGALS3BP) is a tumor-associated immunomodulatory ligand for CD33-related Siglecs.

SIGLEC9 SIGLEC8

1.10e-041055225320078
Pubmed

Cryo-electron microscopy structures of human oligosaccharyltransferase complexes OST-A and OST-B.

RPN1 STT3A

1.34e-041155231831667
Pubmed

Selective Response to Bacterial Infection by Regulating Siglec-E Expression.

SIGLEC9 SIGLEC8

1.34e-041155232889432
Pubmed

TGFβ attenuates cartilage extracellular matrix degradation via enhancing FBXO6-mediated MMP14 ubiquitination.

ABCA2 RPN1 ITGA6 STT3A

1.35e-0416455432409323
Pubmed

Proteomic analysis of mammalian oligosaccharyltransferase reveals multiple subcomplexes that contain Sec61, TRAP, and two potential new subunits.

RPN1 STT3A

1.60e-041255215835887
Pubmed

Identification of candidate proteins binding to prion protein.

MAG DLGAP3

1.60e-04125529173930
Pubmed

CD24-Siglec axis is an innate immune checkpoint against metaflammation and metabolic disorder.

SIGLEC9 SIGLEC8

1.89e-041355235921817
Pubmed

Ptf1a determines GABAergic over glutamatergic neuronal cell fate in the spinal cord dorsal horn.

SLC6A5 SLC17A6

2.21e-041455216291784
Pubmed

Cerebellar nuclei excitatory neurons regulate developmental scaling of presynaptic Purkinje cell number and organ growth.

SLC6A5 SLC17A6

2.21e-041455231742552
Pubmed

Developmental origin of preBötzinger complex respiratory neurons.

SLC6A5 SLC17A6

2.54e-041555221048147
Pubmed

Positive autofeedback regulation of Ptf1a transcription generates the levels of PTF1A required to generate itch circuit neurons.

SLC6A5 SLC17A6

2.54e-041555232241803
Pubmed

A novel reticular node in the brainstem synchronizes neonatal mouse crying with breathing.

SLC6A5 SLC17A6

2.54e-041555234998469
Pubmed

Critical role of GFRα1 in the development and function of the main olfactory system.

ITGA6 SLC17A6

2.54e-041555223197722
Pubmed

Pharmacologic Suppression of B7-H4 Glycosylation Restores Antitumor Immunity in Immune-Cold Breast Cancers.

RPN1 STT3A

3.29e-041755232938586
Pubmed

Distinct genetic control of parasite elimination, dissemination, and disease after Leishmania major infection.

VPREB1 IGLV7-46

3.29e-041755219705113
Pubmed

The BMP antagonist gremlin 1 contributes to the development of cortical excitatory neurons, motor balance and fear responses.

MAG RYR3

3.29e-041755234184027
Pubmed

Genome-wide expression analysis of Ptf1a- and Ascl1-deficient mice reveals new markers for distinct dorsal horn interneuron populations contributing to nociceptive reflex plasticity.

SLC6A5 SLC17A6

3.70e-041855223616538
Pubmed

Expression and distribution of JNK/SAPK-associated scaffold protein JSAP1 in developing and adult mouse brain.

SLC5A7 SLC17A6

3.70e-041855216606357
Pubmed

A physical map of the genomic region on mouse chromosome 3 containing the hindshaker (hsh) mutation.

SELENBP1 SLC50A1

4.13e-041955214706451
Pubmed

IgSF8: a developmentally and functionally regulated cell adhesion molecule in olfactory sensory neuron axons and synapses.

ITGA6 SLC17A6

4.58e-042055222687584
Pubmed

Regulation of the protocadherin Celsr3 gene and its role in globus pallidus development and connectivity.

ACHE SLC17A6

5.06e-042155225113559
Pubmed

Altered heparan sulfate structure in Glce(-/-) mice leads to increased Hedgehog signaling in endochondral bones.

GLCE IHH

5.06e-042155226116392
Pubmed

Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes.

GPLD1 JMJD1C

5.06e-042155218940312
Pubmed

The Epigenetic State of PRDM16-Regulated Enhancers in Radial Glia Controls Cortical Neuron Position.

ITGA6 SLC17A6

5.56e-042255229779941
Pubmed

Overexpression of Galnt3 in chondrocytes resulted in dwarfism due to the increase of mucin-type O-glycans and reduction of glycosaminoglycans.

IHH GALNT7

5.56e-042255225107907
Pubmed

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

OLFML2A ABCA2 RPN1 GLCE ITGA6 GALNT7 SLC33A1 STT3A

5.69e-04120155835696571
Pubmed

Contribution of calumin to embryogenesis through participation in the endoplasmic reticulum-associated degradation activity.

RPN1 IHH

6.63e-042455225009997
Pubmed

Large-scale sequencing of the CD33-related Siglec gene cluster in five mammalian species reveals rapid evolution by multiple mechanisms.

SIGLEC9 SIGLEC8

6.63e-042455215331780
Pubmed

Upregulation of imprinted genes in mice: an insight into the intensity of gene expression and the evolution of genomic imprinting.

PEG10 NNAT

6.63e-042455220168089
Pubmed

Reduced endothelin converting enzyme-1 and endothelin-3 mRNA in the developing bowel of male mice may increase expressivity and penetrance of Hirschsprung disease-like distal intestinal aganglionosis.

ACHE IHH

6.63e-042455217131407
Pubmed

Wdnm1-like, a new adipokine with a role in MMP-2 activation.

SELENBP1 ITGA6

7.20e-042555218492766
Pubmed

A mouse knockout library for secreted and transmembrane proteins.

SIGLEC9 SIGLEC8 C6orf15 WFDC5 NNAT

8.00e-0446055520562862
Pubmed

Excitatory neurons of the proprioceptive, interoceptive, and arousal hindbrain networks share a developmental requirement for Math1.

SLC6A5 SLC17A6

8.40e-042755220080794
Pubmed

Morphology-based mammalian stem cell tests reveal potential developmental toxicity of donepezil.

ACHE DEGS2

8.40e-042755225269881
Pubmed

Disruption of parental-specific expression of imprinted genes in uniparental fetuses.

PEG10 NNAT

9.70e-042955216987518
Pubmed

Roof Plate-Derived Radial Glial-like Cells Support Developmental Growth of Rapidly Adapting Mechanoreceptor Ascending Axons.

SLC6A5 SLC17A6

9.70e-042955229874580
Pubmed

Multiple loci are associated with white blood cell phenotypes.

RPN1 C6orf15

1.26e-033355221738480
Pubmed

GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children.

C6orf15 JMJD1C

1.49e-033655223263863
Pubmed

L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms.

SLC6A7 SLC6A5 RYR3

1.53e-0314355320424473
Pubmed

The transcription factor XBP1 is selectively required for eosinophil differentiation.

SIGLEC9 SIGLEC8

1.58e-033755226147683
Cytoband22q11.2

IGLV1-50 IGLV1-40 IGLV7-46

4.14e-0412055322q11.2
CytobandEnsembl 112 genes in cytogenetic band chr2q35

GLB1L IHH BCS1L

5.11e-04129553chr2q35
CytobandEnsembl 112 genes in cytogenetic band chr22q11

VPREB1 IGLV1-50 IGLV1-40 IGLV7-46

1.62e-03419554chr22q11
Cytoband1p36.13

ZBTB17 IFFO2

2.08e-03565521p36.13
GeneFamilySolute carriers

SLC6A7 SLC50A1 SLC6A5 SLC5A7 SLC5A9 SLC33A1 SLC6A14 SLC17A6

8.56e-07395368752
GeneFamilyCD molecules|C2-set domain containing|Sialic acid binding Ig like lectins

MAG SIGLEC9 SIGLEC8

2.30e-0528363745
GeneFamilyOligosaccharyltransferase complex subunits

RPN1 STT3A

2.51e-0412362445
GeneFamilyImmunoglobulin lambda locus at 22q11.2

IGLV1-50 IGLV1-40 IGLV7-46

7.32e-0489363353
GeneFamilyAdenosine receptors|V-set domain containing

VPREB1 SIGLEC9 SIGLEC8

4.13e-03163363590
CoexpressionKRAS.LUNG_UP.V1_DN

OLFML2A VPREB1 ACHE IHH SLC6A14

1.01e-05142535M2893
CoexpressionMIKKELSEN_MEF_HCP_WITH_H3K27ME3

SLC6A7 OLFML2A DLGAP2 ACHE SLC6A5 DEGS2 IHH SLC17A6

2.31e-05591538M2019
CoexpressionMIKKELSEN_MEF_HCP_WITH_H3K27ME3

SLC6A7 OLFML2A DLGAP2 ACHE SLC6A5 DEGS2 IHH SLC17A6

2.60e-05601538MM866
ToppCellCOVID_non-vent-Lymphocytic-Plasma_cell-IgA_Plasmablast|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

IGLV1-50 IGLV1-40 RPN1 IGLV7-46 STT3A

4.45e-06197555fdbf4eb9fa5aefb4ffb307494fe4774bf5e0aaeb
ToppCellBrain_organoid-organoid_Tanaka_cellReport-6m-Neuronal-Intermediate|6m / Sample Type, Dataset, Time_group, and Cell type.

OLFML2A PEG10 NNAT GALNT7 JMJD1C

4.79e-062005557c261e39ac30b318511373ab7302aa53b8b81b9c
ToppCellPND03-Epithelial-Epithelial_Airway-Neurosecretory-PNEC-PNEC_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FBXO44 SLC6A5 LTK NNAT

6.46e-051755548362a46f5804333baa84cd56d450bc147f372a7e
ToppCellPND03-Epithelial-Epithelial_Airway-Neurosecretory-PNEC|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FBXO44 SLC6A5 LTK NNAT

6.46e-051755548b4c62e608f0ec84e563bbf0ebffe3ed44085298
ToppCellTCGA-Endometrium-Primary_Tumor-Endometrial_Adenocarcinoma-Endometrioid-2|TCGA-Endometrium / Sample_Type by Project: Shred V9

ZBTB17 NAA60 IHH TMEM89

6.60e-05176554179b1778e8f6c4cd777cec971960211e7ba5d84a
ToppCell3'-GW_trimst-2-SmallIntestine-Neuronal-Glial_immature-Glia_1_(DHH+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MAG OLFML2A SLC5A7 ITGA6

7.21e-0518055438490017dd590e3fcfa7e88d8d15235d55f90cf1
ToppCell3'-GW_trimst-2-LargeIntestine-Neuronal-Glial_immature-Glia_1_(DHH+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MAG OLFML2A SLC5A7 ITGA6

7.21e-05180554b294f9db1e2ff51c94cde64fae4c2b057c0030a1
ToppCelldroplet-Large_Intestine|droplet / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SELENBP1 DEGS2 IHH SLC6A14

7.68e-051835549d7ffcb9804b9a52448ccb56c9370b317a4b52a5
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC6A7 DLGAP2 DLGAP3 LTK

8.18e-051865547278a1a1bf9bb27aeb03852134defb31b62f30d6
ToppCelldroplet-Marrow-nan-21m-Lymphocytic-nan|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC50A1 RPN1 SLC33A1 STT3A

8.52e-051885547e27e49ec1eb02fb74c86ec2ccb84751bc778b21
ToppCelldroplet-Marrow-nan-21m-Lymphocytic|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC50A1 RPN1 SLC33A1 STT3A

8.52e-051885544b14c3ad80507245564d5be96d33fd9361f67dd0
ToppCellfacs-Brain_Myeloid-Striatum-3m-Myeloid-nan|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RPN1 ITGA6 JMJD1C STT3A

8.70e-051895546dd4ec5ce4beb856f0d2d1654e3c4676d1d63736
ToppCellfacs-Brain_Myeloid-Striatum-3m-Myeloid|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RPN1 ITGA6 JMJD1C STT3A

8.70e-051895543ae479ec7e00c57127cbe51a398329b10ca9848c
ToppCellfacs-Brain_Myeloid-Striatum-3m-Myeloid-microglial_cell|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RPN1 ITGA6 JMJD1C STT3A

8.70e-05189554875df61ee48baa5142ba4d2427bdec1c53e5a828
ToppCellfacs-Brain_Myeloid-Striatum-3m|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RPN1 ITGA6 JMJD1C STT3A

8.70e-0518955497ef5215d841ff366a3e3682cd9bd04100cbfde0
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Neuronal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC6A7 DLGAP2 DLGAP3 LTK

9.43e-05193554be28070c049e7cb68bcd54f582226eb2f5e4bc1c
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Neuronal-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC6A7 DLGAP2 DLGAP3 LTK

9.43e-051935540c652ebe22ce5d2927599dd97ef1920547858395
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Neuronal-neuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC6A7 DLGAP2 DLGAP3 LTK

9.43e-051935548689a70a33a7c3823dc647d41ac0160e7c3ae396
ToppCell18-Airway-Epithelial-Epithelial|Airway / Age, Tissue, Lineage and Cell class

DLGAP2 ACHE SLC5A7 NNAT

9.62e-05194554d3c90e1f1228f8ba0ba56105c6cf4f302c388f28
ToppCellBrain_organoid-organoid_Paulsen_bioRxiv-1_mon-Neuronal-Subcortical|1_mon / Sample Type, Dataset, Time_group, and Cell type.

ACHE PEG10 NNAT SLC17A6

1.00e-04196554bf8fe28193348342987d361c8e8b9e1d6d542678
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SELENBP1 DEGS2 GALNT7 SLC6A14

1.02e-04197554ff19e4c45715752a04541ad6a0cdf5454c9daaa2
ToppCellB_cells-Plasma_cells_and_plasmablasts|B_cells / Immune cells in Kidney/Urine in Lupus Nephritis

RPN1 ITGA6 SLC33A1 STT3A

1.02e-041975543b1c574b3d119b63967bb1306f0353ecc4c522f3
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)-Club_(non-nasal)_L.0.4.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SELENBP1 DEGS2 GALNT7 SLC6A14

1.04e-041985547896f9fb89822e8628fe0b90a489c4760c7b876c
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-club_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SELENBP1 DEGS2 GALNT7 SLC6A14

1.04e-04198554778fee7020c82d11ff3984a8e482a23e5d58165f
Diseasealkaline phosphatase measurement, liver enzyme measurement

GPLD1 JMJD1C

4.73e-056532EFO_0004533, EFO_0004582
DiseaseSchizophrenia

MAG DLGAP2 SELENBP1 ACHE SLC6A5 BRD1 SLC17A6

9.76e-04883537C0036341
DiseaseDevelopmental Academic Disorder

ACHE SLC17A6

1.25e-0329532C1330966
DiseaseLearning Disorders

ACHE SLC17A6

1.25e-0329532C0023186
DiseaseLearning Disturbance

ACHE SLC17A6

1.25e-0329532C0751263
DiseaseAdult Learning Disorders

ACHE SLC17A6

1.25e-0329532C0751262
DiseaseLearning Disabilities

ACHE SLC17A6

1.25e-0329532C0751265
DiseaseDuchenne muscular dystrophy (implicated_via_orthology)

SLC6A5 SLC6A14

1.92e-0336532DOID:11723 (implicated_via_orthology)
DiseaseMemory Loss

ACHE SLC17A6

2.73e-0343532C0751295
DiseaseAge-Related Memory Disorders

ACHE SLC17A6

2.73e-0343532C0751292
DiseaseMemory Disorder, Spatial

ACHE SLC17A6

2.73e-0343532C0751294
DiseaseMemory Disorder, Semantic

ACHE SLC17A6

2.73e-0343532C0751293

Protein segments in the cluster

PeptideGeneStartEntry
WTPKVEHQGGFPIYY

SLC33A1

396

O00400
SPTPVLVWIYGGGFY

ACHE

141

P22303
LLGPYGRAFPEYPWN

ERFL

216

A0A1W2PQ73
YGVPYIPEGQWLCRH

BRD1

246

O95696
EFVPSPGNHFIWYRG

BCS1L

96

Q9Y276
HYLQVPQDEWGGYPT

DLGAP2

406

Q9P1A6
GVPLSTQWGPQGYFY

GLCE

196

O94923
YGPGVRIGNWNEDVY

CFAP161

6

Q6P656
WTSPAQGPGYSQGYR

CDK13

1481

Q14004
RPAVVHGVWYFNSPY

MAG

51

P20916
IYWVGFAFRNPPGTQ

NNAT

31

Q16517
GYVVHWYQQLPGTAP

IGLV1-50

51

A0A075B6I6
TYVLYINGGHPPWTI

NAA60

176

Q9H7X0
GLQPAYGYGMHPAWV

DOP1B

1506

Q9Y3R5
PIIWQYPNGTHAYSG

JMJD1C

861

Q15652
WRVPGPGQYLISAYG

LTK

111

P29376
YRWASGAQGYVRNPP

NUDT6

26

P53370
YPPGVRYIWFQHGGV

FBXO44

216

Q9H4M3
PTYPVGFAWYPVGRD

PEG10

646

Q86TG7
HYIVFGAPGTYNWKG

ITGA6

201

P23229
VPHQYYGVTPWGVYP

PUM1

456

Q14671
NRYPGGSWGNIHLYP

C6orf15

276

Q6UXA7
GPGLVIYWYGFIQEL

CDIN1

241

Q9Y2V0
IYRLEGWQGNPPPIY

GALNT7

441

Q86SF2
HYLQVPQDDWGGYPT

DLGAP3

366

O95886
PHGPLVNSEYYTGWL

GLB1L

256

Q6UWU2
YGPLNWITFNVGYHV

DEGS2

246

Q6QHC5
AYWRPGPNTGGRFYF

ABCA2

641

Q9BZC7
PQHYGRLPGTIWSYT

IFFO2

151

Q5TF58
GHYPYWFQQKPGQAP

IGLV7-46

51

A0A075B6I9
TPGEGVHWYPQLLYR

IHH

376

Q14623
PYNWIGTGHVVYQGA

OLFML2A

461

Q68BL7
YVPGYGLAWAQAPIG

SLC5A7

76

Q9GZV3
GYAVGLGNVWRFPYL

SLC6A5

206

Q9Y345
GYDVHWYQQLPGTAP

IGLV1-40

51

P01703
PLFGGWKTHYIVGYN

RPN1

321

P04843
AWYPLGRIIGGTIYP

STT3A

76

P46977
PVHGYWFRAGDRPYQ

SIGLEC8

61

Q9NYZ4
IYPGPVVHGYWFREG

SIGLEC9

51

Q9Y336
GFQDVGWYPGLEQRY

SLC5A9

231

Q2M3M2
GGAAPLGYDFWYQPR

SELENBP1

181

Q13228
IGYCVGLGNVWRFPY

SLC6A7

51

Q99884
YGSYRFPPWAELLGI

SLC6A7

526

Q99884
PVGWIAVYGQGYSPN

C11orf68

116

Q9H3H3
FFWGYIITQIPGGYI

SLC17A6

131

Q9P2U8
PGALPAGQHYLYQRW

WFDC5

156

Q8TCV5
YGSFPYVARPVHWQP

TRMT61B

446

Q9BVS5
GYPDVGWNPIEGERY

RYR3

2181

Q15413
GYGYFWLLVPNPEAR

SLC50A1

111

Q9BRV3
VYSVYWYQQRPGHPP

VPREB1

51

P12018
LGRVYGYFPPNGQSW

GPLD1

621

P80108
ADFYQQYGPGGTWPA

ZBTB17

751

Q13105
GYWLGPGASRIYPVA

TMEM89

56

A2RUT3
GYAVGLGNVWRFPYL

SLC6A14

51

Q9UN76
YGQYMANGWQVPPYG

TIAL1

306

Q01085
ANGWQVPPYGVYGQP

TIAL1

311

Q01085
YLQWYRQDPGRGPVF

TRAV6

71

A0A075B6T7