Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionUDP-glucose:glycoprotein glucosyltransferase activity

UGGT2 UGGT1

7.67e-072182GO:0003980
GeneOntologyMolecularFunctionUDP-glucosyltransferase activity

UGGT2 UGGT1

5.95e-0513182GO:0035251
GeneOntologyMolecularFunctionglucosyltransferase activity

UGGT2 UGGT1

1.75e-0422182GO:0046527
GeneOntologyMolecularFunctionunfolded protein binding

RUVBL2 UGGT2 UGGT1

1.87e-04126183GO:0051082
GeneOntologyMolecularFunctionATP-dependent activity, acting on DNA

RUVBL2 RAD54L2

5.74e-03127182GO:0008094
GeneOntologyMolecularFunctionprotein tyrosine kinase binding

TJP2 PLCG1

7.82e-03149182GO:1990782
GeneOntologyMolecularFunctionUDP-glycosyltransferase activity

UGGT2 UGGT1

8.23e-03153182GO:0008194
GeneOntologyMolecularFunctionhelicase activity

RUVBL2 RAD54L2

8.76e-03158182GO:0004386
GeneOntologyBiologicalProcessUDP-glucosylation

UGGT2 UGGT1

6.39e-072172GO:0097359
GeneOntologyBiologicalProcessUDP-alpha-D-glucose metabolic process

UGGT2 UGGT1

9.57e-066172GO:0006011
GeneOntologyBiologicalProcessprotein N-linked glycosylation via asparagine

UGGT2 UGGT1

1.75e-0424172GO:0018279
DomainUDP-g_GGtrans

UGGT2 UGGT1

8.77e-072182IPR009448
DomainUDP-g_GGTase

UGGT2 UGGT1

8.77e-072182PF06427
DomainVWFD

SUSD2 FCGBP

1.04e-0416182PS51233
DomainVWD

SUSD2 FCGBP

1.04e-0416182SM00216
DomainVWF_type-D

SUSD2 FCGBP

1.04e-0416182IPR001846
DomainVWD

SUSD2 FCGBP

1.04e-0416182PF00094
DomainER_TARGET

UGGT2 UGGT1

9.24e-0447182PS00014
Domain-

UGGT2 UGGT1

2.72e-03811823.90.550.10
DomainNucleotide-diphossugar_trans

UGGT2 UGGT1

3.20e-0388182IPR029044
Pubmed

Quantitative glycoproteomics reveals cellular substrate selectivity of the ER protein quality control sensors UGGT1 and UGGT2.

UGGT2 UGGT1

2.53e-07218233320095
Pubmed

Effects of domain composition on catalytic activity of human UDP-glucose:glycoprotein glucosyltransferases.

UGGT2 UGGT1

2.53e-07218227496766
Pubmed

The noncatalytic portion of human UDP-glucose: glycoprotein glucosyltransferase I confers UDP-glucose binding and transferase function to the catalytic domain.

UGGT2 UGGT1

2.53e-07218212913004
Pubmed

Both isoforms of human UDP-glucose:glycoprotein glucosyltransferase are enzymatically active.

UGGT2 UGGT1

2.53e-07218224415556
Pubmed

Two homologues encoding human UDP-glucose:glycoprotein glucosyltransferase differ in mRNA expression and enzymatic activity.

UGGT2 UGGT1

2.53e-07218210694380
Pubmed

Progesterone regulates the expression and activity of two mouse isoforms of the glycoprotein folding sensor UDP-Glc: glycoprotein glucosyltransferase (UGGT).

UGGT2 UGGT1

2.53e-07218224140206
Pubmed

Association between the 15-kDa selenoprotein and UDP-glucose:glycoprotein glucosyltransferase in the endoplasmic reticulum of mammalian cells.

UGGT2 UGGT1

7.59e-07318211278576
Pubmed

EphB6-null mutation results in compromised T cell function.

EPHB4 PLCG1

9.09e-06918215599401
Pubmed

Novel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal differentiation.

DOK4 PLCG1

1.39e-051118211470823
Pubmed

Getting in and out from calnexin/calreticulin cycles.

UGGT2 UGGT1

1.97e-051318218303019
Pubmed

A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity.

RUVBL2 UGGT2 UGGT1

5.53e-0514518323349634
Pubmed

Hemodynamic force is required for vascular smooth muscle cell recruitment to blood vessels during mouse embryonic development.

EPHB4 SEMA3A

6.94e-052418230796970
Pubmed

Noggin is required for correct guidance of dorsal root ganglion axons.

EPHB4 SEMA3A

1.02e-042918212435358
Pubmed

The proximal proteome of 17 SARS-CoV-2 proteins links to disrupted antiviral signaling and host translation.

EPHB4 RUVBL2 UGGT2 SPAG7 UGGT1

1.26e-04100718534597346
Pubmed

Protein interaction profiling of the p97 adaptor UBXD1 points to a role for the complex in modulating ERGIC-53 trafficking.

RUVBL2 UGGT1

1.49e-043518222337587
Pubmed

TrkB-dependent EphrinA reverse signaling regulates callosal axon fasciculate growth downstream of Neurod2/6.

SEMA3A PLCG1

2.70e-044718235462405
Pubmed

Systematic analyses of the ultraviolet radiation resistance-associated gene product (UVRAG) protein interactome by tandem affinity purification.

RUVBL2 UGGT1

2.81e-044818226590968
Pubmed

Protein partners in the life history of activated fibroblast growth factor receptors.

RUVBL2 PLCG1

4.25e-045918218022941
Pubmed

An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.

TJP2 UGGT2 SPAG7 UGGT1

4.73e-0473318434672954
CytobandEnsembl 112 genes in cytogenetic band chr19q13

RUVBL2 CPT1C FCGBP

1.06e-021192183chr19q13
GeneFamilyUDP-glucose glycoprotein glucosyltransferases

UGGT2 UGGT1

4.04e-072122440
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

DOK4 PLCG1

7.91e-03206122682
ToppCellE18.5-samps-Epithelial-Alveolar_epithelial-AT1|E18.5-samps / Age Group, Lineage, Cell class and subclass

SEMA3A TKTL2 FCGBP

1.86e-05130183eb16a8f8f62add5fdd29c78d4608b6d1a06767f1
ToppCelldroplet-Heart-HEART_(ALL_4:4:4:1:1)-30m-Endothelial-endocardial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SEMA3A PLCG1 EML6

3.27e-05157183a426c54fd1545093d41426e9620862f71bd06f6b
ToppCell356C-Myeloid-Macrophage-FABP4+_Macrophage_4|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

EPHB4 DOK4 SUSD2

4.37e-05173183ef8d720b99470fe1953661f6e66bc0366266bdb6
ToppCell356C-Myeloid-Macrophage-FABP4+_Macrophage_4|Macrophage / Donor, Lineage, Cell class and subclass (all cells)

EPHB4 DOK4 SUSD2

4.45e-05174183110369f6b78de34a6d934b5b47cecd023347bc80
ToppCelldroplet-Marrow-nan-18m-Myeloid-basophil|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TJP2 UGGT2 UGGT1

4.45e-0517418355cc8300489d11322724159ec7d0e1d32a702e91
ToppCellPND01-03-samps-Endothelial-Postnatal_endothelial|PND01-03-samps / Age Group, Lineage, Cell class and subclass

EPHB4 DOK4 DENND2B

5.77e-051901835130fb325f80f591b9b36beacb8072c4472304f2
ToppCellPND01-03-samps-Endothelial|PND01-03-samps / Age Group, Lineage, Cell class and subclass

EPHB4 DOK4 DENND2B

5.77e-051901831357bd4527399d7013ee33272bda7453f472999a
ToppCellfacs-Lung-nan-3m-Endothelial|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPHB4 SEMA3A PLCG1

6.24e-051951837f9b7f15006610ad591063d90e90367bd6083c7f
Drugfluphenazine dihydrochloride; Down 200; 10uM; MCF7; HT_HG-U133A

DOK4 DENND2B PLCG1 RAD54L2

1.34e-051911845234_DN
DrugAlexidine dihydrochloride [22573-93-9]; Down 200; 6.8uM; MCF7; HT_HG-U133A

EPHB4 DOK4 PLCG1 RAD54L2

1.42e-051941844721_DN
DrugAcetylsalicylsalicylic acid [530-75-6]; Down 200; 13.4uM; MCF7; HT_HG-U133A

DOK4 DENND2B PLCG1 RAD54L2

1.45e-051951842223_DN
DrugBicuculline (+) [485-49-4]; Down 200; 10.8uM; HL60; HT_HG-U133A

EPHB4 PLCG1 RAD54L2 KLHL26

1.54e-051981842139_DN
DrugPD153035

EPHB4 SEMA3A PLCG1

1.30e-04127183CID000004705
Drugbeta-damascenone

SUSD2 FCGBP

1.61e-0424182ctd:C075388
Druglomustine; Down 200; 100uM; PC3; HT_HG-U133A

EPHB4 DENND2B KLHL26

3.63e-041801837094_DN
DrugFR221647

TJP2 DENND2B

3.87e-0437182CID005288241
Drug23 B

SEMA3A FCGBP

4.08e-0438182CID000011060
DrugPromazine hydrochloride [53-60-1]; Down 200; 12.4uM; MCF7; HT_HG-U133A

DENND2B PLCG1 RAD54L2

4.26e-041901833927_DN
Drug0317956-0000 [391210-11-0]; Down 200; 10uM; MCF7; HT_HG-U133A

EPHB4 DOK4 DENND2B

4.32e-041911833855_DN
DrugTrichostatin A, from Streptomyces sp.; Up 200; 0.1uM; HL60; HT_HG-U133A

EPHB4 SEMA3A PLCG1

4.39e-041921833114_UP
DrugDipyrone [5907-38-0]; Up 200; 12uM; PC3; HT_HG-U133A

EPHB4 PLCG1 RAD54L2

4.52e-041941834310_UP
DrugAmyleine hydrochloride [532-59-2]; Down 200; 14.8uM; MCF7; HT_HG-U133A

EPHB4 PLCG1 RAD54L2

4.52e-041941834169_DN
DrugAcetylsalicylsalicylic acid [530-75-6]; Down 200; 13.4uM; MCF7; HT_HG-U133A

EPHB4 DOK4 KLHL26

4.52e-041941836778_DN
DrugTridihexethyl chloride; Up 200; 11.4uM; MCF7; HT_HG-U133A

EPHB4 DOK4 RAD54L2

4.52e-041941833526_UP
DrugFluphenazine dihydrochloride [146-56-5]; Down 200; 7.8uM; MCF7; HT_HG-U133A

EPHB4 RAD54L2 KLHL26

4.52e-041941833194_DN
DrugNefopam hydrochloride [23327-57-3]; Up 200; 13.8uM; MCF7; HT_HG-U133A

SEMA3A DOK4 RAD54L2

4.59e-041951832317_UP
DrugLoperamide hydrochloride [34552-83-5]; Down 200; 7.8uM; PC3; HG-U133A

SEMA3A RUVBL2 UGGT2

4.59e-041951831949_DN
DrugIsoconazole [27523-40-6]; Down 200; 9.6uM; PC3; HT_HG-U133A

EPHB4 SEMA3A KLHL26

4.59e-041951835857_DN
DrugPhenelzine sulfate [156-51-4]; Down 200; 17uM; MCF7; HT_HG-U133A

DOK4 PLCG1 KLHL26

4.59e-041951834360_DN
DrugHarmaline hydrochloride dihydrate [6027-98-1]; Up 200; 14uM; MCF7; HT_HG-U133A

DOK4 DENND2B RAD54L2

4.59e-041951832805_UP
DrugQuinidine hydrochloride monohydrate [6151-40-2]; Down 200; 10.6uM; MCF7; HT_HG-U133A

EPHB4 RAD54L2 KLHL26

4.59e-041951833191_DN
Drug6-Hydroxytropinone [5932-53-6]; Down 200; 25.8uM; MCF7; HT_HG-U133A

EPHB4 DOK4 UGGT2

4.66e-041961834833_DN
DrugVigabatrin [60643-86-9]; Down 200; 31uM; HL60; HT_HG-U133A

EPHB4 TJP2 PLCG1

4.73e-041971832452_DN
Drug2-propylpentanoic acid; Down 200; 200uM; MCF7; HT_HG-U133A

PLCG1 RAD54L2 KLHL26

4.73e-041971835211_DN
DrugMorantel tartrate [26155-31-7]; Up 200; 10.8uM; MCF7; HT_HG-U133A

EPHB4 PLCG1 RAD54L2

4.73e-041971831676_UP
DrugNS-398; Down 200; 10uM; MCF7; HT_HG-U133A

DOK4 SPAG7 PLCG1

4.73e-041971836897_DN
DrugBetahistine mesylate [54856-23-4]; Down 200; 17.2uM; PC3; HT_HG-U133A

DOK4 SPAG7 PLCG1

4.73e-041971836611_DN
DrugTolbutamide [64-77-7]; Down 200; 14.8uM; MCF7; HT_HG-U133A

DENND2B PLCG1 RAD54L2

4.73e-041971833886_DN
DrugYohimbinic acid monohydrate [27801-27-2]; Up 200; 11.2uM; MCF7; HT_HG-U133A

DENND2B RAD54L2 KLHL26

4.73e-041971832803_UP
DrugICI 182,780; Down 200; 1uM; PC3; HG-U133A

TJP2 UGGT1 PLCG1

4.73e-04197183704_DN
Drugpioglitazone HCl; Down 200; 10uM; MCF7; HT_HG-U133A

EPHB4 DENND2B PLCG1

4.73e-041971837523_DN
DrugDeltaline [6836-11-9]; Down 200; 7.8uM; MCF7; HT_HG-U133A

DOK4 DENND2B RAD54L2

4.73e-041971833831_DN
DrugPyridoxine hydrochloride [58-56-0]; Up 200; 19.4uM; MCF7; HT_HG-U133A

DOK4 PLCG1 RAD54L2

4.73e-041971832751_UP
DrugCondelphine [7633-69-4]; Up 200; 8.8uM; HL60; HT_HG-U133A

EPHB4 PLCG1 RAD54L2

4.80e-041981832976_UP
Druggentamicin

DENND2B UGGT1 PLCG1

4.80e-04198183CID000003467
DrugPirenperone [ 75444-65-4]; Down 200; 10.2uM; HL60; HT_HG-U133A

EPHB4 PLCG1 KLHL26

4.80e-041981832455_DN
Drug6-Furfurylaminopurine [525-79-1]; Down 200; 18.6uM; MCF7; HT_HG-U133A

EPHB4 DOK4 RAD54L2

4.80e-041981836073_DN
DrugGlibenclamide [10238-21-8]; Down 200; 8uM; PC3; HT_HG-U133A

EPHB4 DENND2B KLHL26

4.80e-041981835849_DN
DrugTetrahydroalstonine [6474-90-4]; Down 200; 11.4uM; MCF7; HT_HG-U133A

PLCG1 RAD54L2 KLHL26

4.87e-041991836209_DN
Drug(R)-(+)-Atenolol [56715-13-0]; Down 200; 15uM; MCF7; HT_HG-U133A

EPHB4 DENND2B RAD54L2

4.87e-041991832855_DN
DrugProparacaine hydrochloride [5875-06-9]; Up 200; 12uM; MCF7; HT_HG-U133A

DOK4 PLCG1 RAD54L2

4.87e-041991836492_UP
DrugCefazolin sodium salt [27164-46-1]; Down 200; 8.4uM; MCF7; HT_HG-U133A

DOK4 SPAG7 PLCG1

4.87e-041991834708_DN
DrugDropropizine (R,S) [17692-31-8]; Up 200; 17uM; MCF7; HT_HG-U133A

EPHB4 DOK4 RAD54L2

4.87e-041991837429_UP
DrugMeclocycline sulfosalicylate [73816-42-9]; Up 200; 5.8uM; MCF7; HT_HG-U133A

DOK4 PLCG1 RAD54L2

4.87e-041991834982_UP
Drugrosiglitazone; Down 200; 10uM; MCF7; HT_HG-U133A

DOK4 PLCG1 RAD54L2

4.94e-042001835230_DN
DrugTrichlormethiazide [133-67-5]; Down 200; 10.6uM; MCF7; HT_HG-U133A

PLCG1 RAD54L2 KLHL26

4.94e-042001834783_DN
DrugMinocycline hydrochloride [13614-98-7]; Up 200; 8uM; MCF7; HT_HG-U133A

EPHB4 DOK4 KLHL26

4.94e-042001837436_UP
DiseaseFEV/FEC ratio

DENND2B UGGT2 CPT1C FCGBP

4.60e-031228174EFO_0004713

Protein segments in the cluster

PeptideGeneStartEntry
YTQFMDRFRDCGSSG

RAD54L2

591

Q9Y4B4
FMLTGEDGSRRFGYC

DENND2B

766

P78524
MGRYEESFAAAGFGS

EPHB4

921

P54760
ACFMAYTFERESSGE

OAZ1

211

P54368
FRDRGQFCLTYESAM

CPT1C

576

Q8TCG5
LAACSDYFRAMFTGG

KLHL26

81

Q53HC5
DGRRFDFMGTCTYLL

FCGBP

876

Q9Y6R7
TTFDGRRFDFMGTCV

FCGBP

1261

Q9Y6R7
YTTFDGRRFDFMGTC

FCGBP

2461

Q9Y6R7
FSMYACEEGFATGGR

EML6

241

Q6ZMW3
ATRFTFEAGRMCDAG

DOK4

191

Q8TEW6
GRSFTRARDYDAMGS

RUVBL2

206

Q9Y230
RADSGRFFTDYGCDM

SUSD2

321

Q9UGT4
RFFTDYGCDMEQGSV

SUSD2

326

Q9UGT4
TSFSFGEDDDCRYVM

SPAG7

91

O75391
LYSGTAADFMGRDFA

SEMA3A

186

Q14563
EVMDEFDGRSFRSGY

TJP2

141

Q9UDY2
ASYRVFCLMGDGESS

TKTL2

146

Q9H0I9
GTERACYRDMSSFPE

PLCG1

971

P19174
GYTPFCDSRREMDGY

UGGT2

1356

Q9NYU1
GYTPFCDSRREMDGY

UGGT1

1381

Q9NYU2
MCFSRADAADNYPFG

PIFO

1

Q8TCI5