Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	phosphatidylinositol 3-kinase regulator activity	IRS2 KLF4	2.86e-04	18	28	2	GO:0035014
GeneOntologyMolecularFunction	chromatin binding	SFPQ RERE FOXA2 KLF4 TLE1 BAHCC1	4.72e-04	739	28	6	GO:0003682
GeneOntologyMolecularFunction	transcription factor binding	SOX17 NR4A3 RARB FOXA2 KLF4 TLE1	5.21e-04	753	28	6	GO:0008134
GeneOntologyMolecularFunction	beta-catenin binding	DVL3 SOX17 KLF4	6.21e-04	120	28	3	GO:0008013
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	SOX17 NR4A3 RARB FOXA2 KLF4 ZNF517 ZIC5 FUBP1	6.60e-04	1459	28	8	GO:0000977
GeneOntologyMolecularFunction	protein-macromolecule adaptor activity	DVL3 IRS2 RERE KMT2E KLF4 RBM33 TLE1	8.83e-04	1160	28	7	GO:0030674
GeneOntologyMolecularFunction	DNA-binding transcription factor binding	SOX17 NR4A3 RARB KLF4 TLE1	1.17e-03	582	28	5	GO:0140297
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	SOX17 NR4A3 RARB FOXA2 KLF4 ZIC5 FUBP1	1.33e-03	1244	28	7	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	SOX17 NR4A3 RARB FOXA2 KLF4 ZIC5 FUBP1	1.51e-03	1271	28	7	GO:0000987
GeneOntologyMolecularFunction	molecular adaptor activity	DVL3 IRS2 RERE KMT2E KLF4 RBM33 TLE1	2.19e-03	1356	28	7	GO:0060090
GeneOntologyMolecularFunction	RNA polymerase II-specific DNA-binding transcription factor binding	SOX17 NR4A3 RARB KLF4	2.58e-03	417	28	4	GO:0061629
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	SOX17 NR4A3 RARB FOXA2 KLF4 ZNF517 ZIC5	2.76e-03	1412	28	7	GO:0000981
GeneOntologyMolecularFunction	nuclear receptor activity	NR4A3 RARB	3.19e-03	60	28	2	GO:0004879
GeneOntologyMolecularFunction	ligand-activated transcription factor activity	NR4A3 RARB	3.30e-03	61	28	2	GO:0098531
GeneOntologyBiologicalProcess	formation of primary germ layer	SOX17 NR4A3 FOXA2 KLF4	2.28e-05	124	28	4	GO:0001704
GeneOntologyBiologicalProcess	embryonic morphogenesis	DVL3 SOX17 NR4A3 RARB FOXA2 KLF4 ZIC5	3.59e-05	713	28	7	GO:0048598
GeneOntologyBiologicalProcess	tissue morphogenesis	DVL3 SOX17 NR4A3 FOXA2 KLF4 ZIC5 EGLN1	4.96e-05	750	28	7	GO:0048729
GeneOntologyBiologicalProcess	tube development	DVL3 SOX17 NR4A3 RARB AMOTL2 FOXA2 KLF4 ZIC5 EGLN1	6.39e-05	1402	28	9	GO:0035295
GeneOntologyBiologicalProcess	tube morphogenesis	DVL3 SOX17 NR4A3 AMOTL2 FOXA2 KLF4 ZIC5 EGLN1	8.91e-05	1125	28	8	GO:0035239
GeneOntologyBiologicalProcess	brain development	DVL3 NR4A3 IRS2 RERE RARB FOXA2 ZIC5	1.17e-04	859	28	7	GO:0007420
GeneOntologyBiologicalProcess	neural tube development	DVL3 SOX17 FOXA2 ZIC5	1.52e-04	202	28	4	GO:0021915
GeneOntologyBiologicalProcess	head development	DVL3 NR4A3 IRS2 RERE RARB FOXA2 ZIC5	1.77e-04	919	28	7	GO:0060322
GeneOntologyBiologicalProcess	gastrulation	SOX17 NR4A3 FOXA2 KLF4	1.83e-04	212	28	4	GO:0007369
GeneOntologyBiologicalProcess	cellular response to peptide	IRS2 KLF4	1.85e-04	15	28	2	GO:1901653
GeneOntologyBiologicalProcess	animal organ morphogenesis	DVL3 SOX17 NBL1 NR4A3 RARB FOXA2 TLE1 EGLN1	2.06e-04	1269	28	8	GO:0009887
GeneOntologyBiologicalProcess	regulation of type B pancreatic cell proliferation	NR4A3 IRS2	3.67e-04	21	28	2	GO:0061469
GeneOntologyBiologicalProcess	positive regulation of transcription by RNA polymerase II	DVL3 SOX17 NR4A3 SFPQ RARB FOXA2 KLF4 EGLN1	3.83e-04	1390	28	8	GO:0045944
GeneOntologyBiologicalProcess	embryo development	DVL3 SOX17 NR4A3 RARB FOXA2 KLF4 ZIC5 EGLN1	4.80e-04	1437	28	8	GO:0009790
GeneOntologyBiologicalProcess	U2-type prespliceosome assembly	SF3B4 SF3A2	5.23e-04	25	28	2	GO:1903241
GeneOntologyBiologicalProcess	Wnt signaling pathway	DVL3 SOX17 AMOTL2 KLF4 TLE1	5.87e-04	516	28	5	GO:0016055
GeneOntologyBiologicalProcess	anatomical structure formation involved in morphogenesis	DVL3 SOX17 NR4A3 AMOTL2 FOXA2 KLF4 ZIC5 EGLN1	5.93e-04	1483	28	8	GO:0048646
GeneOntologyBiologicalProcess	signal transduction involved in regulation of gene expression	SOX17 FOXA2	6.57e-04	28	28	2	GO:0023019
GeneOntologyCellularComponent	chromatin	DVL3 SOX17 NR4A3 SFPQ RARB KMT2E FOXA2 KLF4 SLX4	6.35e-05	1480	27	9	GO:0000785
GeneOntologyCellularComponent	transcription regulator complex	SOX17 NR4A3 SFPQ FOXA2 KLF4 TLE1	9.30e-05	596	27	6	GO:0005667
GeneOntologyCellularComponent	U2 snRNP	SF3B4 SF3A2	5.95e-04	28	27	2	GO:0005686
GeneOntologyCellularComponent	nuclear protein-containing complex	SFPQ SF3B4 RERE KMT2E SF3A2 TLE1 SLX4	1.46e-03	1377	27	7	GO:0140513
GeneOntologyCellularComponent	U2-type precatalytic spliceosome	SF3B4 SF3A2	1.97e-03	51	27	2	GO:0071005
GeneOntologyCellularComponent	nuclear speck	CBLL1 SFPQ KMT2E SF3A2	2.15e-03	431	27	4	GO:0016607
GeneOntologyCellularComponent	precatalytic spliceosome	SF3B4 SF3A2	2.21e-03	54	27	2	GO:0071011
GeneOntologyCellularComponent	euchromatin	KMT2E KLF4	3.88e-03	72	27	2	GO:0000791
GeneOntologyCellularComponent	histone deacetylase complex	RERE KMT2E	5.37e-03	85	27	2	GO:0000118
GeneOntologyCellularComponent	nuclear body	CBLL1 SFPQ RERE KMT2E SF3A2	5.44e-03	903	27	5	GO:0016604
GeneOntologyCellularComponent	spliceosomal snRNP complex	SF3B4 SF3A2	6.80e-03	96	27	2	GO:0097525
GeneOntologyCellularComponent	U2-type spliceosomal complex	SF3B4 SF3A2	6.94e-03	97	27	2	GO:0005684
GeneOntologyCellularComponent	small nuclear ribonucleoprotein complex	SF3B4 SF3A2	8.38e-03	107	27	2	GO:0030532
MousePheno	perinatal lethality	SOX17 RERE KMT2E FOXA2 KLF4 ZIC5 FUBP1 SLX4 BAHCC1	4.12e-05	1130	23	9	MP:0002081
MousePheno	reduced female fertility	SOX17 IRS2 KMT2E FOXA2 SLX4	1.01e-04	296	23	5	MP:0001923
MousePheno	perinatal lethality, incomplete penetrance	SOX17 KMT2E FOXA2 FUBP1 SLX4 BAHCC1	1.26e-04	503	23	6	MP:0011090
MousePheno	craniofacial phenotype	DVL3 SFPQ SF3B4 RERE RARB FOXA2 KLF4 ZIC5 SLX4	1.88e-04	1372	23	9	MP:0005382
MousePheno	abnormal craniofacial morphology	DVL3 SFPQ SF3B4 RERE RARB FOXA2 KLF4 ZIC5 SLX4	1.88e-04	1372	23	9	MP:0000428
MousePheno	abnormal pulmonary alveolar sac morphology	RARB FUBP1	2.00e-04	13	23	2	MP:0010902
MousePheno	abnormal forebrain morphology	NR4A3 IRS2 SF3B4 RERE ZIC5 FUBP1 SLX4 IQSEC2	2.01e-04	1072	23	8	MP:0000783
MousePheno	abnormal head morphology	DVL3 SFPQ SF3B4 RERE FOXA2 KLF4 ZIC5 SLX4	2.73e-04	1120	23	8	MP:0000432
MousePheno	lethality during fetal growth through weaning, incomplete penetrance	DVL3 SOX17 RERE KMT2E FOXA2 FUBP1 SLX4 BAHCC1	2.79e-04	1124	23	8	MP:0011112
MousePheno	abnormal cerebral hemisphere morphology	NR4A3 RERE ZIC5 FUBP1 SLX4 IQSEC2	3.26e-04	599	23	6	MP:0008540
MousePheno	abnormal facial morphology	DVL3 SFPQ RERE FOXA2 KLF4 ZIC5 SLX4	4.71e-04	910	23	7	MP:0003743
MousePheno	abnormal hippocampus development	NR4A3 ZIC5	4.83e-04	20	23	2	MP:0000808
Domain	-	NR4A3 RERE RARB	7.48e-05	57	27	3	3.30.50.10
Domain	Znf_NHR/GATA	NR4A3 RERE RARB	7.88e-05	58	27	3	IPR013088
Domain	BAH	RERE BAHCC1	1.10e-04	11	27	2	SM00439
Domain	BAH	RERE BAHCC1	1.10e-04	11	27	2	PF01426
Domain	BAH_dom	RERE BAHCC1	1.10e-04	11	27	2	IPR001025
Domain	BAH	RERE BAHCC1	1.10e-04	11	27	2	PS51038
Domain	zf-C4	NR4A3 RARB	2.00e-03	46	27	2	PF00105
Domain	NUCLEAR_REC_DBD_1	NR4A3 RARB	2.00e-03	46	27	2	PS00031
Domain	Znf_hrmn_rcpt	NR4A3 RARB	2.00e-03	46	27	2	IPR001628
Domain	Nuclear_hrmn_rcpt	NR4A3 RARB	2.00e-03	46	27	2	IPR001723
Domain	ZnF_C4	NR4A3 RARB	2.00e-03	46	27	2	SM00399
Domain	NUCLEAR_REC_DBD_2	NR4A3 RARB	2.00e-03	46	27	2	PS51030
Domain	-	NR4A3 RARB	2.09e-03	47	27	2	1.10.565.10
Domain	HOLI	NR4A3 RARB	2.18e-03	48	27	2	SM00430
Domain	Nucl_hrmn_rcpt_lig-bd	NR4A3 RARB	2.18e-03	48	27	2	IPR000536
Domain	Hormone_recep	NR4A3 RARB	2.18e-03	48	27	2	PF00104
Domain	RRM	SFPQ SF3B4 RBM33	3.68e-03	217	27	3	SM00360
Domain	RRM_dom	SFPQ SF3B4 RBM33	4.18e-03	227	27	3	IPR000504
Domain	RRM	SFPQ SF3B4 RBM33	4.33e-03	230	27	3	PS50102
Domain	-	SFPQ SF3B4 RBM33	5.11e-03	244	27	3	3.30.70.330
Domain	Znf_C2H2-like	CBLL1 KLF4 ZNF517 ZIC5 SF3A2	5.13e-03	796	27	5	IPR015880
Domain	ZnF_C2H2	CBLL1 KLF4 ZNF517 ZIC5 SF3A2	5.47e-03	808	27	5	SM00355
Domain	Nucleotide-bd_a/b_plait	SFPQ SF3B4 RBM33	5.96e-03	258	27	3	IPR012677
Domain	-	CBLL1 KLF4 ZNF517 ZIC5	1.56e-02	679	27	4	3.30.160.60
Domain	Znf_C2H2/integrase_DNA-bd	CBLL1 KLF4 ZNF517 ZIC5	1.68e-02	694	27	4	IPR013087
Pathway	WP_MESODERMAL_COMMITMENT_PATHWAY	SOX17 RARB FOXA2 KLF4 ZIC5	3.20e-06	153	22	5	M39546
Pathway	PID_BETA_CATENIN_NUC_PATHWAY	DVL3 KLF4 TLE1	2.51e-04	80	22	3	M223
Pathway	REACTOME_FORMATION_OF_DEFINITIVE_ENDODERM	SOX17 FOXA2	3.12e-04	17	22	2	M48030
Pathway	WP_NCRNAS_INVOLVED_IN_WNT_SIGNALING_IN_HEPATOCELLULAR_CARCINOMA	DVL3 SOX17 KLF4	3.43e-04	89	22	3	M39563
Pathway	WP_FOXA2_PATHWAY	IRS2 FOXA2	4.80e-04	21	22	2	M42579
Pathway	WP_MRNA_PROCESSING	SFPQ SF3B4 SF3A2	9.48e-04	126	22	3	M39406
Pathway	WP_CELL_LINEAGE_MAP_FOR_NEURONAL_DIFFERENTIATION	SOX17 FOXA2 KLF4	1.08e-03	132	22	3	M48110
Pathway	REACTOME_DEACTIVATION_OF_THE_BETA_CATENIN_TRANSACTIVATING_COMPLEX	SOX17 TLE1	1.12e-03	32	22	2	MM14975
Pathway	WP_TYPE_2_PAPILLARY_RENAL_CELL_CARCINOMA	SFPQ EGLN1	1.27e-03	34	22	2	M39771
Pathway	WP_ENDODERM_DIFFERENTIATION	SOX17 FOXA2 ZIC5	1.37e-03	143	22	3	M39591
Pathway	REACTOME_TCF_DEPENDENT_SIGNALING_IN_RESPONSE_TO_WNT	DVL3 SOX17 TLE1	1.82e-03	158	22	3	MM14791
Pathway	REACTOME_DEACTIVATION_OF_THE_BETA_CATENIN_TRANSACTIVATING_COMPLEX	SOX17 TLE1	1.93e-03	42	22	2	M27272
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	CBLL1 NR4A3 SFPQ SF3B4 RERE KMT2E FOXA2 RBM33 SF3A2 SLX4 IQSEC2	1.01e-09	1203	28	11	29180619
Pubmed	Loss of a mammalian circular RNA locus causes miRNA deregulation and affects brain function.	NR4A3 IRS2 KLF4	1.02e-07	12	28	3	28798046
Pubmed	Micropattern differentiation of mouse pluripotent stem cells recapitulates embryo regionalized cell fate patterning.	SOX17 FOXA2 KLF4	5.28e-07	20	28	3	29412136
Pubmed	Involvement of histone acetylation of Sox17 and Foxa2 promoters during mouse definitive endoderm differentiation revealed by microRNA profiling.	SOX17 FOXA2	6.25e-07	2	28	2	22132182
Pubmed	Novel roles of hakai in cell proliferation and oncogenesis.	CBLL1 SFPQ	6.25e-07	2	28	2	19535458
Pubmed	Pdx1 expression in Irs2-deficient mouse beta-cells is regulated in a strain-dependent manner.	IRS2 FOXA2	1.87e-06	3	28	2	12869553
Pubmed	Down-regulation of SOX17, GATA4 and FoxA2 promotes differentiation potential of hepatocytes from human hematopoietic stem cells.	SOX17 FOXA2	1.87e-06	3	28	2	32433020
Pubmed	Charting Brachyury-mediated developmental pathways during early mouse embryogenesis.	SOX17 FOXA2	1.87e-06	3	28	2	24616493
Pubmed	Endogenous purification reveals GREB1 as a key estrogen receptor regulatory factor.	SF3B4 KLF4 RBM33 TLE1	2.04e-06	113	28	4	23403292
Pubmed	Crucial transcription factors in endoderm and embryonic gut development are expressed in gut-like structures from mouse ES cells.	SOX17 FOXA2	3.75e-06	4	28	2	16210401
Pubmed	Biphasic modulation of Wnt signaling supports efficient foregut endoderm formation from human pluripotent stem cells.	SOX17 FOXA2	3.75e-06	4	28	2	26861571
Pubmed	Dynamic expression of Groucho-related genes Grg1 and Grg3 in foregut endoderm and antagonism of differentiation.	FOXA2 TLE1	3.75e-06	4	28	2	20108349
Pubmed	Retinoic acid regulates morphogenesis and patterning of posterior foregut derivatives.	RARB FOXA2	6.24e-06	5	28	2	16806149
Pubmed	Regionalization of cell fates and cell movement in the endoderm of the mouse gastrula and the impact of loss of Lhx1(Lim1) function.	SOX17 FOXA2	6.24e-06	5	28	2	15355796
Pubmed	Transducin-like enhancer of split proteins, the human homologs of Drosophila groucho, interact with hepatic nuclear factor 3beta.	FOXA2 TLE1	6.24e-06	5	28	2	10748198
Pubmed	TNIP2 is a Hub Protein in the NF-κB Network with Both Protein and RNA Mediated Interactions.	CBLL1 SFPQ SF3B4 AMOTL2 ZIC5 TLE1 FUBP1	6.55e-06	922	28	7	27609421
Pubmed	Functional association of U2 snRNP with the ATP-independent spliceosomal complex E.	SF3B4 SF3A2	9.36e-06	6	28	2	10882114
Pubmed	Expression Profiling and Functional Analysis of Candidate Col10a1 Regulators Identified by the TRAP Program.	SOX17 KLF4	9.36e-06	6	28	2	34276786
Pubmed	The Sox17-mCherry fusion mouse line allows visualization of endoderm and vascular endothelial development.	SOX17 FOXA2	9.36e-06	6	28	2	22121118
Pubmed	Myotubularin-related proteins 3 and 4 interact with polo-like kinase 1 and centrosomal protein of 55 kDa to ensure proper abscission.	DVL3 IRS2 TLE1 SLX4	9.60e-06	167	28	4	25659891
Pubmed	Human transcription factor protein interaction networks.	SOX17 RERE KLF4 RBM33 ATXN7L1 TLE1 FUBP1 SLX4	1.19e-05	1429	28	8	35140242
Pubmed	A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities.	SFPQ KMT2E ATXN7L1 SF3A2	1.29e-05	180	28	4	24104479
Pubmed	Dominant role of DNA methylation over H3K9me3 for IAP silencing in endoderm.	SOX17 FOXA2	1.31e-05	7	28	2	36123357
Pubmed	The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth.	IRS2 FOXA2	1.31e-05	7	28	2	12488434
Pubmed	Spatiotemporal-resolved protein networks profiling with photoactivation dependent proximity labeling.	SFPQ SF3B4 RBM33 SF3A2 FUBP1	1.53e-05	399	28	5	35987950
Pubmed	Dominant and context-specific control of endodermal organ allocation by Ptf1a.	SOX17 FOXA2	1.74e-05	8	28	2	25371369
Pubmed	The orphan steroid receptor Nur77 family member Nor-1 is essential for early mouse embryogenesis.	NR4A3 FOXA2	1.74e-05	8	28	2	13129926
Pubmed	Interactomic analysis of REST/NRSF and implications of its functional links with the transcription suppressor TRIM28 during neuronal differentiation.	SFPQ RERE AMOTL2 SF3A2	2.15e-05	205	28	4	27976729
Pubmed	Tiam1 regulates the Wnt/Dvl/Rac1 signaling pathway and the differentiation of midbrain dopaminergic neurons.	DVL3 FOXA2	2.80e-05	10	28	2	23109420
Pubmed	MicroRNA-127 Promotes Mesendoderm Differentiation of Mouse Embryonic Stem Cells by Targeting Left-Right Determination Factor 2.	SOX17 FOXA2	2.80e-05	10	28	2	27072135
Pubmed	A novel U2 and U11/U12 snRNP protein that associates with the pre-mRNA branch site.	SF3B4 SF3A2	2.80e-05	10	28	2	11500380
Pubmed	Recognition sequences for the GYF domain reveal a possible spliceosomal function of CD2BP2.	SFPQ SF3B4	2.80e-05	10	28	2	15105431
Pubmed	SOX17 links gut endoderm morphogenesis and germ layer segregation.	SOX17 FOXA2	2.80e-05	10	28	2	25419850
Pubmed	Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.	SFPQ FOXA2 RBM33 TLE1 FUBP1	2.94e-05	457	28	5	32344865
Pubmed	Meteorin regulates mesendoderm development by enhancing nodal expression.	SOX17 FOXA2	3.42e-05	11	28	2	24558432
Pubmed	Revising the embryonic origin of thyroid C cells in mice and humans.	SOX17 FOXA2	3.42e-05	11	28	2	26395490
Pubmed	Retinoid signaling in progenitors controls specification and regeneration of the urothelium.	RARB FOXA2	3.42e-05	11	28	2	23993789
Pubmed	Foxh1 and Foxa2 are not required for formation of the midgut and hindgut definitive endoderm.	SOX17 FOXA2	3.42e-05	11	28	2	19896480
Pubmed	Defects of the body plan of mutant embryos lacking Lim1, Otx2 or Hnf3beta activity.	SOX17 FOXA2	4.10e-05	12	28	2	11291865
Pubmed	Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing.	SFPQ SF3B4 RBM33 SF3A2 FUBP1	4.76e-05	506	28	5	30890647
Pubmed	TMEM132A regulates mouse hindgut morphogenesis and caudal development.	SOX17 FOXA2	4.85e-05	13	28	2	37390294
Pubmed	Epithelial cell plasticity drives endoderm formation during gastrulation.	SOX17 FOXA2	4.85e-05	13	28	2	34168324
Pubmed	Mesodermal retinoic acid signaling regulates endothelial cell coalescence in caudal pharyngeal arch artery vasculogenesis.	RARB FOXA2	4.85e-05	13	28	2	22040871
Pubmed	A Sprouty4 reporter to monitor FGF/ERK signaling activity in ESCs and mice.	SOX17 FOXA2	4.85e-05	13	28	2	29964027
Pubmed	Mixl1 is required for axial mesendoderm morphogenesis and patterning in the murine embryo.	SOX17 FOXA2	4.85e-05	13	28	2	12117810
Pubmed	Foxa2 mediates critical functions of prechordal plate in patterning and morphogenesis and is cell autonomously required for early ventral endoderm morphogenesis.	SOX17 FOXA2	4.85e-05	13	28	2	23213408
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	DVL3 SF3B4 RARB AMOTL2 SF3A2 SLX4 IQSEC2	5.53e-05	1285	28	7	35914814
Pubmed	Depletion of definitive gut endoderm in Sox17-null mutant mice.	SOX17 FOXA2	5.65e-05	14	28	2	11973269
Pubmed	Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.	RERE KLF4 RBM33 TLE1	6.10e-05	268	28	4	33640491
Pubmed	The ability of inner-cell-mass cells to self-renew as embryonic stem cells is acquired following epiblast specification.	SOX17 FOXA2 KLF4	7.17e-05	100	28	3	24859004
Pubmed	A census of human transcription factors: function, expression and evolution.	SOX17 NR4A3 RERE RARB FOXA2 KLF4	7.18e-05	908	28	6	19274049
Pubmed	Structure of the human activated spliceosome in three conformational states.	SF3B4 SF3A2	7.45e-05	16	28	2	29360106
Pubmed	Wnt/β-catenin signalling regulates Sox17 expression and is essential for organizer and endoderm formation in the mouse.	SOX17 FOXA2	7.45e-05	16	28	2	23824574
Pubmed	Dual lineage-specific expression of Sox17 during mouse embryogenesis.	SOX17 FOXA2	7.45e-05	16	28	2	22865702
Pubmed	Redundant roles of Tead1 and Tead2 in notochord development and the regulation of cell proliferation and survival.	SOX17 FOXA2	7.45e-05	16	28	2	18332127
Pubmed	Oct4 regulates the embryonic axis and coordinates exit from pluripotency and germ layer specification in the mouse embryo.	SOX17 FOXA2	8.44e-05	17	28	2	29915126
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	CBLL1 SFPQ SF3B4 RBM33 FUBP1 SLX4	9.42e-05	954	28	6	36373674
Pubmed	Stem cells. m6A mRNA methylation facilitates resolution of naïve pluripotency toward differentiation.	SOX17 FOXA2	9.49e-05	18	28	2	25569111
Pubmed	Loss of Apela Peptide in Mice Causes Low Penetrance Embryonic Lethality and Defects in Early Mesodermal Derivatives.	SOX17 FOXA2	9.49e-05	18	28	2	28854362
Pubmed	Atrophin 2 recruits histone deacetylase and is required for the function of multiple signaling centers during mouse embryogenesis.	RERE FOXA2	9.49e-05	18	28	2	14645126
Pubmed	Pancreas-specific Cre driver lines and considerations for their prudent use.	SOX17 FOXA2	9.49e-05	18	28	2	23823474
Pubmed	Neurog3-dependent pancreas dysgenesis causes ectopic pancreas in Hes1 mutant mice.	SOX17 FOXA2	9.49e-05	18	28	2	30093553
Pubmed	Identification of FUBP1 as a Long Tail Cancer Driver and Widespread Regulator of Tumor Suppressor and Oncogene Alternative Splicing.	SFPQ SF3A2 FUBP1	1.06e-04	114	28	3	31553912
Pubmed	A crucial role for Arf6 in the response of commissural axons to Slit.	FOXA2 IQSEC2	1.06e-04	19	28	2	30674481
Pubmed	Post-gastrulation synthetic embryos generated ex utero from mouse naive ESCs.	SOX17 FOXA2	1.06e-04	19	28	2	35988542
Pubmed	Quantitative lineage analysis identifies a hepato-pancreato-biliary progenitor niche.	SOX17 FOXA2	1.06e-04	19	28	2	34433966
Pubmed	Dual embryonic origin of the mammalian enteric nervous system.	SOX17 FOXA2	1.18e-04	20	28	2	30472119
Pubmed	Math1 target genes are enriched with evolutionarily conserved clustered E-box binding sites.	DVL3 NBL1	1.18e-04	20	28	2	16679559
Pubmed	Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.	CBLL1 SFPQ SF3B4 RERE RBM33 SF3A2 TLE1	1.19e-04	1451	28	7	30550785
Pubmed	A genome-scale RNAi screen for Oct4 modulators defines a role of the Paf1 complex for embryonic stem cell identity.	SFPQ SF3B4	1.30e-04	21	28	2	19345177
Pubmed	Mechanisms of the RNA helicases DDX42 and DDX46 in human U2 snRNP assembly.	SF3B4 SF3A2	1.30e-04	21	28	2	36797247
Pubmed	Molecular architecture of the human 17S U2 snRNP.	SF3B4 SF3A2	1.30e-04	21	28	2	32494006
Pubmed	Embryo model completes gastrulation to neurulation and organogenesis.	SOX17 FOXA2	1.43e-04	22	28	2	36007540
Pubmed	Stromal netrin 1 coordinates renal arteriogenesis and mural cell differentiation.	SOX17 KLF4	1.43e-04	22	28	2	37823339
Pubmed	The microenvironment patterns the pluripotent mouse epiblast through paracrine Furin and Pace4 proteolytic activities.	SOX17 FOXA2	1.43e-04	22	28	2	21896659
Pubmed	Retinoic acid signalling induces the differentiation of mouse fetal liver-derived hepatic progenitor cells.	RARB FOXA2	1.56e-04	23	28	2	19737349
Pubmed	Dkk1 and Wnt3 interact to control head morphogenesis in the mouse.	SOX17 FOXA2	1.71e-04	24	28	2	18403408
Pubmed	Expression of Groucho/TLE proteins during pancreas development.	FOXA2 TLE1	1.71e-04	24	28	2	18778483
Pubmed	Structural and functional modularity of the U2 snRNP in pre-mRNA splicing.	SF3B4 SF3A2	1.71e-04	24	28	2	31744343
Pubmed	Interaction network of human early embryonic transcription factors.	RERE TLE1 SLX4 BAHCC1	1.72e-04	351	28	4	38297188
Pubmed	Crucial role for Mst1 and Mst2 kinases in early embryonic development of the mouse.	SOX17 FOXA2	1.85e-04	25	28	2	19786569
Pubmed	Lhx1 functions together with Otx2, Foxa2, and Ldb1 to govern anterior mesendoderm, node, and midline development.	SOX17 FOXA2	1.85e-04	25	28	2	26494787
Pubmed	Regulation of planar cell polarity by Smurf ubiquitin ligases.	DVL3 FOXA2	1.85e-04	25	28	2	19379695
Pubmed	Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex.	SF3B4 SF3A2	1.85e-04	25	28	2	9731529
Pubmed	Differential regulation of alternate promoter regions in Sox17 during endodermal and vascular endothelial development.	SOX17 FOXA2	1.85e-04	25	28	2	36046192
Pubmed	Stepwise reprogramming of liver cells to a pancreas progenitor state by the transcriptional regulator Tgif2.	SOX17 FOXA2	2.01e-04	26	28	2	28193997
Pubmed	Hepatic Notch2 deficiency leads to bile duct agenesis perinatally and secondary bile duct formation after weaning.	SOX17 FOXA2	2.01e-04	26	28	2	25446530
Pubmed	Cripto is essential to capture mouse epiblast stem cell and human embryonic stem cell pluripotency.	SOX17 FOXA2	2.17e-04	27	28	2	27586544
Pubmed	Loss of LKB1 leads to impaired epithelial integrity and cell extrusion in the early mouse embryo.	SOX17 FOXA2	2.33e-04	28	28	2	25588837
Pubmed	TET-mediated DNA demethylation controls gastrulation by regulating Lefty-Nodal signalling.	SOX17 FOXA2	2.33e-04	28	28	2	27760115
Pubmed	Novel genes differentially expressed in cortical regions during late neurogenesis.	NR4A3 ZIC5	2.33e-04	28	28	2	17614941
Pubmed	Diverse Functions of Retinoic Acid in Brain Vascular Development.	SOX17 RARB	2.33e-04	28	28	2	27445154
Pubmed	The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation.	SFPQ SF3B4 RBM33	2.47e-04	152	28	3	38360978
Pubmed	WW domains provide a platform for the assembly of multiprotein networks.	SFPQ SF3B4 SF3A2	2.57e-04	154	28	3	16055720
Pubmed	ER71 acts downstream of BMP, Notch, and Wnt signaling in blood and vessel progenitor specification.	SOX17 FOXA2	2.68e-04	30	28	2	18462699
Pubmed	Correct patterning of the primitive streak requires the anterior visceral endoderm.	SOX17 FOXA2	2.68e-04	30	28	2	21445260
Pubmed	Generation of functional multipotent adult stem cells from GPR125+ germline progenitors.	SOX17 FOXA2	2.68e-04	30	28	2	17882221
Pubmed	Wdpcp, a PCP protein required for ciliogenesis, regulates directional cell migration and cell polarity by direct modulation of the actin cytoskeleton.	DVL3 FOXA2	2.68e-04	30	28	2	24302887
Pubmed	Ubiquitin-assisted phase separation of dishevelled-2 promotes Wnt signalling.	DVL3 IRS2 EGLN1	2.93e-04	161	28	3	36398662
Pubmed	Distinct expression of select and transcriptome-wide isolated 3'UTRs suggests critical roles in development and transition states.	FOXA2 KLF4	3.25e-04	33	28	2	33951080
Interaction	RNF4 interactions	CBLL1 NR4A3 SFPQ SF3B4 RERE KMT2E FOXA2 RBM33 SF3A2 SLX4 IQSEC2	8.78e-07	1412	27	11	int:RNF4
Interaction	CRNKL1 interactions	DVL3 SF3B4 SF3A2 FUBP1 SLX4	3.41e-06	177	27	5	int:CRNKL1
Interaction	GSC interactions	RERE FOXA2 TLE1 BAHCC1	5.27e-06	87	27	4	int:GSC
Interaction	TLE1 interactions	SOX17 FOXA2 KLF4 TLE1 FUBP1	8.41e-06	213	27	5	int:TLE1
Interaction	HDAC1 interactions	DVL3 IRS2 SFPQ RERE RARB KMT2E KLF4 TLE1 BAHCC1	8.46e-06	1108	27	9	int:HDAC1
Interaction	MUS81 interactions	SFPQ ATXN7L1 SF3A2 SLX4	1.29e-05	109	27	4	int:MUS81
Interaction	RBM10 interactions	CBLL1 SF3B4 SF3A2 FUBP1 SLX4	1.93e-05	253	27	5	int:RBM10
Interaction	SNW1 interactions	DVL3 SFPQ SF3B4 RBM33 SF3A2 FUBP1 SLX4	4.34e-05	747	27	7	int:SNW1
Interaction	SART1 interactions	SFPQ KMT2E SF3A2 FUBP1 SLX4	5.67e-05	317	27	5	int:SART1
Interaction	KDM6A interactions	SOX17 RERE KLF4 TLE1	6.11e-05	162	27	4	int:KDM6A
Interaction	ILF2 interactions	CBLL1 SFPQ SF3B4 KMT2E KLF4 SF3A2	1.07e-04	590	27	6	int:ILF2
Interaction	ZNF281 interactions	SOX17 KLF4 SLX4 EGLN1	1.30e-04	197	27	4	int:ZNF281
Interaction	SIN3A interactions	NR4A3 SFPQ KMT2E TLE1 FUBP1	1.33e-04	380	27	5	int:SIN3A
Interaction	EN2 interactions	FOXA2 TLE1	1.56e-04	14	27	2	int:EN2
Interaction	TNIP2 interactions	CBLL1 SFPQ SF3B4 AMOTL2 ZIC5 TLE1 FUBP1	1.98e-04	952	27	7	int:TNIP2
Interaction	ERG interactions	SFPQ RERE TLE1 SLX4	2.10e-04	223	27	4	int:ERG
Interaction	NUP35 interactions	SFPQ FOXA2 RBM33 TLE1 FUBP1	2.22e-04	424	27	5	int:NUP35
Interaction	DDX17 interactions	CBLL1 SFPQ SF3B4 SF3A2 SLX4	2.27e-04	426	27	5	int:DDX17
Interaction	BUB3 interactions	RERE SF3A2 FUBP1 SLX4	2.44e-04	232	27	4	int:BUB3
Interaction	ACTC1 interactions	SFPQ SF3B4 RBM33 SF3A2 FUBP1 SLX4	2.60e-04	694	27	6	int:ACTC1
Interaction	HOXA5 interactions	DVL3 SOX17 FOXA2	2.65e-04	94	27	3	int:HOXA5
Interaction	TLE5 interactions	DVL3 SOX17 SF3B4 KLF4 TLE1	2.72e-04	443	27	5	int:TLE5
Interaction	EYA4 interactions	DVL3 SFPQ SF3B4 RBM33	2.91e-04	243	27	4	int:EYA4
Interaction	DHX40 interactions	RBM33 ATXN7L1 FUBP1 SLX4	3.19e-04	249	27	4	int:DHX40
Interaction	SNRNP200 interactions	SFPQ SF3B4 RBM33 SF3A2 SLX4	3.23e-04	460	27	5	int:SNRNP200
Interaction	SIX3 interactions	NR4A3 TLE1	3.24e-04	20	27	2	int:SIX3
Interaction	SALL1 interactions	SOX17 FOXA2 SLX4	3.37e-04	102	27	3	int:SALL1
Interaction	WBP4 interactions	SFPQ SF3B4 SF3A2	4.10e-04	109	27	3	int:WBP4
Interaction	REST interactions	SFPQ RERE AMOTL2 SF3A2	4.58e-04	274	27	4	int:REST
Cytoband	7q22.3	CBLL1 ATXN7L1	6.77e-05	20	28	2	7q22.3
Cytoband	Ensembl 112 genes in cytogenetic band chr7q22	CBLL1 KMT2E ATXN7L1	3.21e-04	219	28	3	chr7q22
Cytoband	Ensembl 112 genes in cytogenetic band chr9q31	NR4A3 KLF4	3.18e-03	137	28	2	chr9q31
GeneFamily	Nuclear hormone receptors	NR4A3 RARB	1.46e-03	49	21	2	71
GeneFamily	RNA binding motif containing	SFPQ SF3B4 RBM33	1.83e-03	213	21	3	725
Coexpression	HARALAMBIEVA_PBMC_FLUARIX_AGE_50_74YO_CORR_WITH_28D_MEM_B_CELL_RESPONSE_AT_28DY_POSITIVE	DVL3 NR4A3 IRS2 SFPQ KLF4 KCNC3 SLX4 IQSEC2 BAHCC1	3.76e-06	1250	28	9	M41099
Coexpression	BLANCO_MELO_COVID19_SARS_COV_2_INFECTION_CALU3_CELLS_UP	NR4A3 IRS2 AMOTL2 KLF4 BAHCC1	2.70e-05	339	28	5	M34012
Coexpression	GSE6259_33D1_POS_VS_DEC205_POS_SPLENIC_DC_UP	IRS2 RERE RBM33 IQSEC2	5.08e-05	193	28	4	M6730
Coexpression	LEE_DIFFERENTIATING_T_LYMPHOCYTE	SFPQ KMT2E RBM33 FUBP1	5.95e-05	201	28	4	M2200
CoexpressionAtlas	ratio_induced-DefinitiveEndoderm_vs_StemCell_top-relative-expression-ranked_500	SOX17 NBL1 RARB AMOTL2 FOXA2 BAHCC1	3.79e-05	495	28	6	PCBC_ratio_DE_vs_SC_500
CoexpressionAtlas	ratio_induced-DefinitiveEndoderm_vs_StemCell_top-relative-expression-ranked_500_k-means-cluster#2	NBL1 RARB AMOTL2 BAHCC1	6.99e-05	170	28	4	ratio_DE_vs_SC_500_K2
CoexpressionAtlas	ratio_induced-DefinitiveEndoderm_vs_StemCell_top-relative-expression-ranked_500_k-means-cluster#1	SOX17 NBL1 RARB AMOTL2 FOXA2	1.16e-04	374	28	5	ratio_DE_vs_SC_500_K1
ToppCell	facs-Mammary_Gland-Mammary_Gland-21m\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NR4A3 IRS2 SFPQ SF3A2	5.36e-06	186	28	4	bd1185592aedebccd1007dbf2dd2f549fcdf9f42
ToppCell	facs-Mammary_Gland-Mammary_Gland-21m-Epithelial\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NR4A3 IRS2 SFPQ SF3A2	5.71e-06	189	28	4	965e0e388251e7318f8b463816dc96ccb4658677
ToppCell	mLN-T_cell-Th17\|T_cell / Region, Cell class and subclass	NBL1 IRS2 KLF4 TLE1	6.86e-06	198	28	4	efdc9515dd9fb20ef9c8ddc106d88cbdde7d6ea2
ToppCell	Severe-B_naive-8\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	IRS2 TLE1 BAHCC1	1.01e-04	145	28	3	a24cad86509208bc7267b02ef1d1b0a25a2a7043
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c02-GPR183\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	NBL1 NR4A3 IRS2	1.54e-04	167	28	3	4b6853efefea5178280ba7c31facda0fbd1cc469
ToppCell	P07-Epithelial-epithelial_progenitor_cell\|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	FOXA2 KCNC3 PHGR1	1.59e-04	169	28	3	ec23caecbb0d969307e33e9df8499ddcd1420305
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Epithelial-goblet\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FOXA2 KLF4 PHGR1	1.62e-04	170	28	3	9bea81031cdfe45e8cddac3a3afd9ca6c331c45a
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Epithelial-goblet-Goblet_cell\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FOXA2 KLF4 PHGR1	1.62e-04	170	28	3	2c5a1469e5743870e96e6c2cc92f0c5096b79f51
ToppCell	wk_15-18-Epithelial-Proximal_epithelial-Pulmonary_NE_precursor\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	FOXA2 PHGR1 ZIC5	1.62e-04	170	28	3	98d13dbd76a826e47d55553f9d11f71c043b573e
ToppCell	Severe-B_naive-8\|Severe / disease group and sub_cluster of B and Plasma cells(res = 0.5)	IRS2 TLE1 BAHCC1	1.73e-04	174	28	3	f3f8c924420f46321bd47e2b97f18c7241541599
ToppCell	systemic_lupus_erythematosus-managed\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	NR4A3 IRS2 KLF4	1.79e-04	176	28	3	e406a05345461d23cba21c5444223c937143e96a
ToppCell	PND07-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2-AT2_prolif\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FOXA2 KCNC3 PHGR1	1.89e-04	179	28	3	bf012825e88626e59cd1deebf67c2cd269ce4829
ToppCell	3'-GW_trimst-2-LargeIntestine-Epithelial-goblet-Goblet_cell\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FOXA2 KLF4 PHGR1	2.04e-04	184	28	3	886d2d9bf2fe31207f17e3edc309ef44029924e1
ToppCell	3'-GW_trimst-2-LargeIntestine-Epithelial-goblet\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FOXA2 KLF4 PHGR1	2.04e-04	184	28	3	936b39377eebea3961d702532779f6cd27953be7
ToppCell	facs-Brain_Myeloid-Cortex\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FOXA2 KLF4 PHGR1	2.04e-04	184	28	3	17f63dd671f9ff3dd2860d8de41b05c35c095950
ToppCell	droplet-Mammary_Gland-nan-18m-Mesenchymal-nan\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NBL1 RARB KLF4	2.04e-04	184	28	3	fe4d3def3da4ffdea5ae6bb059f5397efd58fef3
ToppCell	facs-Bladder-nan-18m\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SOX17 SF3B4 SF3A2	2.08e-04	185	28	3	3e00879466e626aa8604efecfc4678d64f54dbfc
ToppCell	Control-Lymphoid-ILC_A\|Lymphoid / Disease state, Lineage and Cell class	NR4A3 RERE TLE1	2.08e-04	185	28	3	520795866d44def5be3910ce8e728045c716a24d
ToppCell	facs-Bladder-nan-18m-Epithelial\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SOX17 SF3B4 SF3A2	2.08e-04	185	28	3	3dc5812c961ff209f197ff4cbfb90009c0537550
ToppCell	ILEUM-inflamed-(1)_T_cell-(1)_Cytotoxic_CD8_Trm\|(1)_T_cell / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	NR4A3 KMT2E TLE1	2.18e-04	188	28	3	c80956649b10b7dd7540394a00fc2a0619b27e80
ToppCell	facs-Mammary_Gland-Mammary_Gland-18m\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NR4A3 KLF4 SF3A2	2.18e-04	188	28	3	5e13725136114e42d3b59647cf25e0f3c53abb54
ToppCell	facs-MAT-Fat-18m\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SF3B4 PHGR1 SF3A2	2.18e-04	188	28	3	7f0cda7aab442aa9511d4c35569ec2389e014a71
ToppCell	droplet-Lung-nan-18m-Epithelial-type_II_pneumocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FOXA2 KCNC3 PHGR1	2.21e-04	189	28	3	e5325f1c7430b574947f8ee67e425455b60dc518
ToppCell	droplet-Lung-nan-18m-Epithelial-Alveolar_Epithelial_Type_2\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FOXA2 KCNC3 PHGR1	2.21e-04	189	28	3	ca657353f2b649530809c0bc057e448adc511ec1
ToppCell	renal_medulla_nuclei-Adult_normal_reference\|renal_medulla_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group	RERE RARB TLE1	2.25e-04	190	28	3	f1363f7806cfc4f14fbc1b0e8dac2de813a88eee
ToppCell	facs-Mammary_Gland-Mammary_Gland-18m-Epithelial\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NR4A3 KLF4 SF3A2	2.25e-04	190	28	3	92456f6f7eced6e4c4371f495254a65d061c8d0b
ToppCell	droplet-Lung-18m-Epithelial-alveolar_epithelial-type_II_pneumocyte-type_2_alveolar_epithelial_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FOXA2 KCNC3 PHGR1	2.25e-04	190	28	3	a51405f8466fc6d4087873137472619b2e84c1da
ToppCell	droplet-Lung-18m-Epithelial-alveolar_epithelial-type_II_pneumocyte\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FOXA2 KCNC3 PHGR1	2.25e-04	190	28	3	059beca1c92181b8ba4dcd6fc71ff7530d83d0de
ToppCell	11.5-Airway-Epithelial-Neuroendocrine\|Airway / Age, Tissue, Lineage and Cell class	FOXA2 PHGR1 ZIC5	2.28e-04	191	28	3	c1bb3ae5c297f55cdadf5b6e53d5296389d5099e
ToppCell	droplet-Lung-18m-Epithelial-alveolar_epithelial\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FOXA2 KCNC3 PHGR1	2.28e-04	191	28	3	caed913e7ede9f8ae3af273d1ecf375de6c5e813
ToppCell	human_hepatoblastoma-Tumor_cells\|World / Sample and Cell Type and Tumor Cluster (all cells)	RERE KMT2E RBM33	2.32e-04	192	28	3	916fbec1c7ab7969bda711886ac88e877e30c280
ToppCell	facs-Diaphragm\|facs / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NBL1 NR4A3 IRS2	2.32e-04	192	28	3	486cbf9791ca619e307e8b18aa70ce22111f4f26
ToppCell	metastatic_Lymph_Node-Myeloid_cells-Monocytes\|metastatic_Lymph_Node / Location, Cell class and cell subclass	NR4A3 IRS2 KLF4	2.35e-04	193	28	3	e67e960a5312ed73c5169795cb282e431866b9c1
ToppCell	human_hepatoblastoma\|World / Sample and Cell Type and Tumor Cluster (all cells)	RERE KMT2E RBM33	2.35e-04	193	28	3	e6a688bc834f845ff64dae1be64f073eec5091a1
ToppCell	droplet-Lung-21m-Endothelial-venous_endothelial\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	AMOTL2 KLF4 TLE1	2.39e-04	194	28	3	db7b0c77ad88f7b74d85679f1fb8ee7140ac3f62
ToppCell	3'-Child04-06-SmallIntestine-Epithelial-goblet-Goblet_cell\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FOXA2 KLF4 PHGR1	2.39e-04	194	28	3	49cc5f5de4380302100e8cd937f08abe317ac75e
ToppCell	droplet-Lung-21m-Endothelial-venous_endothelial-vein_endothelial_cell\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	AMOTL2 KLF4 TLE1	2.39e-04	194	28	3	17d530982789acc5e6889b215f3d433d138a41c4
ToppCell	3'-Child04-06-SmallIntestine-Epithelial-goblet\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FOXA2 KLF4 PHGR1	2.39e-04	194	28	3	fb935df966c451e659b8bde281f8aebcb632f6cf
ToppCell	droplet-Lung-21m-Endothelial-venous_endothelial-vein_endothelial_cell-vein_endothelial_cell\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	AMOTL2 KLF4 TLE1	2.39e-04	194	28	3	5992b9409d5855eff2afc3acd201ccd25420d2e0
ToppCell	metastatic_Brain-Myeloid_cells-Monocytes\|metastatic_Brain / Location, Cell class and cell subclass	NR4A3 IRS2 KLF4	2.42e-04	195	28	3	dfc24ee09bdc20d8a38feb8a4cc5f6b54a032981
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_II-G\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	NBL1 NR4A3 KLF4	2.42e-04	195	28	3	fa8ac154e5aebc26463ff84f0ad1038095770bc6
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_anti-infl-D\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	NBL1 NR4A3 KLF4	2.42e-04	195	28	3	d07a8cfecf7a54cf6274565b1649e735abb79c87
ToppCell	facs-Trachea\|facs / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NBL1 NR4A3 IRS2	2.46e-04	196	28	3	34020d6553309daa269dff05de0a8567211ea4d2
ToppCell	5'-Adult-LargeIntestine-Epithelial-goblet\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FOXA2 KLF4 PHGR1	2.46e-04	196	28	3	847b3377f463bfded046eec63cc1b547f3dc33c1
ToppCell	facs-Trachea\|facs / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	NBL1 NR4A3 IRS2	2.46e-04	196	28	3	8209f2b0f7efebaaf81d642d18a1aee8a9a8dcf6
ToppCell	5'-Adult-LargeIntestine-Epithelial-goblet-BEST2+_Goblet_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FOXA2 KLF4 PHGR1	2.50e-04	197	28	3	d624f3a105b19f19a0dd253ce8de3ed13adc1f01
ToppCell	B_cells-Naive_B_cells_\|B_cells / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	NR4A3 IRS2 SFPQ	2.50e-04	197	28	3	fd5fdc5289d681d59ff22d72e4de6e74c6c7aac6
ToppCell	tumor_Lung-T/NK_cells-CD8+/CD4+_Mixed_Th\|T/NK_cells / Location, Cell class and cell subclass	NBL1 NR4A3 SFPQ	2.50e-04	197	28	3	dcce1c3dc5f3e53c368f758eb0fd5afcd86325e7
ToppCell	390C-Lymphocytic-NK_cells-NK_cell_A\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	NR4A3 SFPQ KMT2E	2.54e-04	198	28	3	a1c8e5c332336823c47c04e56b6d7bc8f057c9da
ToppCell	3'-GW_trimst-1-SmallIntestine-Epithelial-goblet\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FOXA2 KLF4 PHGR1	2.54e-04	198	28	3	9c5d7852f03468394e726c444cac92a043fc6d0e
ToppCell	10x3'2.3-week_14-16-Mesenchymal_osteo-stroma-osteoblast_precursor\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	NBL1 RARB AMOTL2	2.54e-04	198	28	3	9d61483b0decac2fe90045b3474843360b2c49b3
ToppCell	3'-GW_trimst-1-SmallIntestine-Epithelial-goblet-Goblet_cell\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FOXA2 KLF4 PHGR1	2.54e-04	198	28	3	f95f38cc747fb3549a791288bf8d0518c049ac96
ToppCell	mLN-ILC\|mLN / Region, Cell class and subclass	NBL1 KLF4 TLE1	2.57e-04	199	28	3	d6c299312c747fb1b7c53644c53efc03a5fffe85
ToppCell	mLN-(3)_ILC\|mLN / shred on region, Cell_type, and subtype	NBL1 KLF4 TLE1	2.57e-04	199	28	3	00e0e2a766dd9c4d0a65f53d88fa50df4b6a3d60
ToppCell	Skin-Mesangial\|Skin / Skin and Kidney Cells in Lupus Nephritis Patients.	KCNC3 ZIC5 IQSEC2	2.57e-04	199	28	3	bcb78838a91cc7828680fb413fbacdb091c5fac0
ToppCell	mLN-(3)_ILC-(30)_ILC\|mLN / shred on region, Cell_type, and subtype	NBL1 KLF4 TLE1	2.57e-04	199	28	3	33ac6d77099076df01299be429f4ba96f2f34cc1
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_anti-infl-G\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	NBL1 NR4A3 KLF4	2.57e-04	199	28	3	550590b1e9c1930cbbe9cf7a141c7aeb07413096
ToppCell	mLN-ILC-ILC\|mLN / Region, Cell class and subclass	NBL1 KLF4 TLE1	2.57e-04	199	28	3	ab09a06cdea2597e9fe4b4b304655e9de4d433f6
ToppCell	mild\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	SFPQ KMT2E RBM33	2.61e-04	200	28	3	12f1685ce8f218433068e090c9d839cd5a1910bf
ToppCell	368C-Lymphocytic-NK_cells-NK_cell_E\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	RBM33 EGLN1	1.38e-03	88	28	2	142d2e00ef19c0ad011a21945bf1111271056eae
ToppCell	frontal_cortex-Non-neuronal-endothelial_cell-Endo-Endo_Cytl1\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	SOX17 KLF4	1.92e-03	104	28	2	5d9cd14e53a2f1060e528abf6c0694be9d72c356
ToppCell	356C-Myeloid-Macrophage-SPP1+_Macrophage_4\|Macrophage / Donor, Lineage, Cell class and subclass (all cells)	ZNF517 SLX4	2.07e-03	108	28	2	ee924deacd14ea404fda80ed633960143fd474c0
ToppCell	droplet-Heart-nan-24m-Endothelial-nan\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SOX17 AMOTL2	2.34e-03	115	28	2	e11128262ba1e2a7053b1b6c039f1aab37d2ce27
ToppCell	Hippocampus-Macroglia-POLYDENDROCYTE-P5-P5_2-Sox4-POLYDENDROCYTE_(Neurogenesis.Sox4.Gad2)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	SFPQ FUBP1	2.72e-03	124	28	2	1483be8700eca7e2c288784a290d945d4022b17f
ToppCell	droplet-Trachea-nan-3m-Mesenchymal-mesenchymal_cell\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NBL1 KLF4	2.80e-03	126	28	2	c3261ea8726400de87f1c8a5a5134ba2b2884f66
ToppCell	primary_visual_cortex-Non-neuronal-endothelial_cell-Endo-Endo_Cytl1\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	SOX17 KLF4	2.85e-03	127	28	2	eee8e4a83f7de46807440d202d46eee7dd722001
ToppCell	droplet-Heart-HEART_(ALL_4:4:4:1:1)-30m-Mesenchymal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DVL3 PHGR1	2.98e-03	130	28	2	e5acaa9aaa22b10d11410e2c01647b31354c21ed
ToppCell	NS-moderate-d_07-13-Epithelial-unknown_epithelial\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	RERE KLF4	2.98e-03	130	28	2	1491e8975520e99c527a5b5bee64875d124f7bf4
ToppCell	ILEUM-non-inflamed-(3)_MNP-(3)_moDC\|(3)_MNP / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	NR4A3 KMT2E	3.21e-03	135	28	2	b7a792a7c0c22d8b703509f134115f0e394d7de0
ToppCell	Hippocampus-Macroglia-POLYDENDROCYTE-P5-P5_2\|Hippocampus / BrainAtlas - Mouse McCarroll V32	SFPQ FUBP1	3.26e-03	136	28	2	3e13dc0634f3b05e9f9e6c3193f843f62e603b78
ToppCell	Hippocampus-Macroglia-POLYDENDROCYTE-P5-P5_2-Sox4\|Hippocampus / BrainAtlas - Mouse McCarroll V32	SFPQ FUBP1	3.26e-03	136	28	2	0185486c39700dd2f72d79be6d283494dd8379c9
ToppCell	NS-moderate-d_16-33-Epithelial-unknown_epithelial\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	RERE KLF4	3.30e-03	137	28	2	03e124901a0e85b59b6882bbafab568b50907e8b
ToppCell	(08)_Brush+PNEC-(2)_GFP_FOXI1\|(08)_Brush+PNEC / shred by cell type by condition	RARB KMT2E	3.35e-03	138	28	2	817e3f639604ea95adae01e8685ffaa2e0aff7a8
ToppCell	moderate-Epithelial-unknown_epithelial\|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	RERE KLF4	3.35e-03	138	28	2	afefa8233c67aa744e939156bc538449bf6bd05b
ToppCell	facs-Lung-EPCAM-3m-Hematologic-leukocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RARB PHGR1	3.45e-03	140	28	2	731b46e4b815a45af1d0ce7ab4d0d0324ac8798f
ToppCell	AT1-AT2_cells-Donor_04\|World / lung cells shred on cell class, cell subclass, sample id	AMOTL2 FOXA2	3.45e-03	140	28	2	45d52a086ced8d58e01ac51ac4a90338e8649b16
ToppCell	facs-Lung-EPCAM-3m-Hematologic-Proliferating_Immune\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RARB PHGR1	3.45e-03	140	28	2	b30fc389583406ee6cb55112d0f7250d1b74c88a
ToppCell	facs-Lung-EPCAM-3m-Hematologic\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RARB PHGR1	3.45e-03	140	28	2	35ecd887bb7827603ef673912ba820208a6368d2
ToppCell	NS-critical-d_07-13-Epithelial-unknown_epithelial\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	RERE KLF4	3.49e-03	141	28	2	33ad925ff7be3c682741a6328216a89f9d4033e9
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Myeloid_monocytic-non-classical_monocyte-Non-classical_monocytes-\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NR4A3 SLX4	3.59e-03	143	28	2	7adc34d8ad11e57950a5a258ae9bf8f52259385a
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Myeloid-Dendritic-plasmacytoid_dendritic_cell-DC_c4-LILRA4\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	RARB BAHCC1	3.59e-03	143	28	2	d0ed8c25da1327085e042c2e03cb7503e2c52ce0
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Myeloid-Dendritic-plasmacytoid_dendritic_cell\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	RARB BAHCC1	3.59e-03	143	28	2	8900b92a24289204b9ec7baccc11594fec7694f1
ToppCell	Globus_pallidus-Endothelial-ENDOTHELIAL_STALK-Flt1_1\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	SOX17 KLF4	3.64e-03	144	28	2	1c118b22c2ff3a526a5207d6c9d772636ee065fd
ToppCell	Epithelial-B_(AT1-AT2-progenitors)\|World / shred on cell class and cell subclass (v4)	FOXA2 KCNC3	3.74e-03	146	28	2	4511916904c1fac252cb68e871b782207f8137b3
ToppCell	TCGA-Head_and_Esophagus-Primary_Tumor-Esophageal_Carcinoma-Adenocarcinoma-3\|TCGA-Head_and_Esophagus / Sample_Type by Project: Shred V9	FOXA2 PHGR1	3.74e-03	146	28	2	e55b4acecf4e363b5afa287c747c2e58c4597f3a
ToppCell	facs-Large_Intestine-Distal-3m-Epithelial-Goblet_cell,_top_of_crypt_(Distal)\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KLF4 PHGR1	3.84e-03	148	28	2	f58804d24fe524b42b5090c8658050ea4b14793e
ToppCell	Mild/Remission-B_naive-4\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	IRS2 RERE	3.84e-03	148	28	2	dd5e1bc02824e743e1c030a303e32f27a359a8ca
ToppCell	facs-Large_Intestine-Distal-24m-Epithelial-Goblet_cell,_top_of_crypt_(Distal)\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KLF4 PHGR1	3.84e-03	148	28	2	941bad657064b3d37cae8b66df99c1aa1098c088
ToppCell	TCGA-Head_and_Esophagus-Primary_Tumor-Esophageal_Carcinoma-Adenocarcinoma\|TCGA-Head_and_Esophagus / Sample_Type by Project: Shred V9	FOXA2 PHGR1	3.89e-03	149	28	2	92a8931a51db619fb5f0638d319c02e7838f6559
ToppCell	Control-Epithelial-PNEC\|World / Disease state, Lineage and Cell class	PHGR1 ZIC5	3.89e-03	149	28	2	02b47193621d23a50378d7905d7f85aaab686cfb
ToppCell	Globus_pallidus-Endothelial-ENDOTHELIAL_STALK\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	SOX17 KLF4	3.89e-03	149	28	2	d9c47f523c75ddcd6131e45d2ffc24b970932cae
ToppCell	COVID-19_Severe-B_cell\|World / disease group, cell group and cell class	CBLL1 TLE1	3.89e-03	149	28	2	9a9fcbf7e8a6811958f3fd2d36315e19ab2b1127
ToppCell	367C-Lymphocytic-NK_cells-NK_cell_E\|367C / Donor, Lineage, Cell class and subclass (all cells)	TLE1 SLX4	3.89e-03	149	28	2	f18bddc84b064f3d57a1281d5172c404d87f25da
ToppCell	Control-Epithelial-PNEC\|Control / Disease state, Lineage and Cell class	PHGR1 ZIC5	3.94e-03	150	28	2	d6bbbe9d06a84c3de2a2e200ed512c8e8745f987
ToppCell	TCGA-Bladder-Solid_Tissue_Normal-Urothelial_normal_tissue-Urothelial_normal_tissue-4\|TCGA-Bladder / Sample_Type by Project: Shred V9	SOX17 NR4A3	3.94e-03	150	28	2	bcb99c6fa81052556ab30f9db5875fccf1ae724b
ToppCell	P03-Epithelial-epithelial_progenitor_cell-epi_progenitor\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	FOXA2 KCNC3	3.99e-03	151	28	2	fce04bce66411c21cd5d4d41375f26f1f50f3348
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_MHC-A\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	NR4A3 KCNC3	4.10e-03	153	28	2	099382241971412f84b6feefb897360a74a41143
ToppCell	COVID-19_Severe-B_cell\|COVID-19_Severe / disease group, cell group and cell class	CBLL1 TLE1	4.10e-03	153	28	2	701a7d92ee7b22277c8462742a530347cc6f061a
ToppCell	mild_COVID-19_(asymptomatic)-MAIT\|World / disease group, cell group and cell class (v2)	NR4A3 TLE1	4.10e-03	153	28	2	2b4c69f6db17927d6506a645ac058133e60b0103
ToppCell	mild_COVID-19_(asymptomatic)-MAIT\|mild_COVID-19_(asymptomatic) / disease group, cell group and cell class (v2)	NR4A3 TLE1	4.10e-03	153	28	2	26852f3d8f80e102e24bcb90e24aac26fdc9a32c
Drug	Lanatoside C [17575-22-3]; Up 200; 4uM; MCF7; HT_HG-U133A	NR4A3 IRS2 SFPQ RERE AMOTL2	1.57e-06	164	28	5	3852_UP
Drug	Strophantine octahydrate [11018-89-6]; Up 200; 5.4uM; MCF7; HT_HG-U133A	DVL3 IRS2 SFPQ AMOTL2 IQSEC2	2.41e-06	179	28	5	2656_UP
Drug	Proscillaridin A [466-06-8]; Up 200; 7.6uM; MCF7; HT_HG-U133A	NR4A3 IRS2 SFPQ AMOTL2	4.22e-05	160	28	4	4404_UP
Drug	Digoxigenin [1672-46-4]; Up 200; 10.2uM; MCF7; HT_HG-U133A	NR4A3 IRS2 SFPQ AMOTL2	4.22e-05	160	28	4	5275_UP
Drug	Anisomycin [22862-76-6]; Up 200; 15uM; MCF7; HT_HG-U133A	NR4A3 IRS2 SFPQ KLF4	4.43e-05	162	28	4	2658_UP
Drug	Lanatoside C [17575-22-3]; Up 200; 4uM; PC3; HT_HG-U133A	IRS2 SFPQ AMOTL2 KLF4	4.43e-05	162	28	4	3771_UP
Drug	Lanatoside C [17575-22-3]; Up 200; 4uM; MCF7; HT_HG-U133A	NR4A3 IRS2 SFPQ AMOTL2	4.64e-05	164	28	4	3963_UP
Drug	Digitoxigenin [143-62-4]; Up 200; 10.6uM; MCF7; HT_HG-U133A	IRS2 SFPQ RERE AMOTL2	4.75e-05	165	28	4	3275_UP
Drug	Strophanthidin [66-28-4]; Up 200; 9.8uM; PC3; HT_HG-U133A	IRS2 SFPQ AMOTL2 KLF4	4.87e-05	166	28	4	5826_UP
Drug	Digitoxigenin [143-62-4]; Up 200; 10.6uM; MCF7; HT_HG-U133A	NR4A3 IRS2 SFPQ AMOTL2	4.98e-05	167	28	4	4801_UP
Drug	Strophanthidin [66-28-4]; Up 200; 9.8uM; MCF7; HT_HG-U133A	NR4A3 IRS2 SFPQ AMOTL2	5.10e-05	168	28	4	6087_UP
Drug	Lycorine hydrochloride [2188-68-3]; Up 200; 12.4uM; MCF7; HT_HG-U133A	CBLL1 NR4A3 IRS2 AMOTL2	5.10e-05	168	28	4	4365_UP
Drug	felodipine; Up 200; 10uM; MCF7; HT_HG-U133A_EA	NR4A3 IRS2 SFPQ KLF4	5.34e-05	170	28	4	965_UP
Drug	Strophantine octahydrate [11018-89-6]; Up 200; 5.4uM; MCF7; HT_HG-U133A	NR4A3 IRS2 SFPQ AMOTL2	5.46e-05	171	28	4	5026_UP
Drug	0179445-0000 [211246-22-9]; Up 200; 10uM; MCF7; HT_HG-U133A	SFPQ RERE ATXN7L1 FUBP1	6.53e-05	179	28	4	3630_UP
Drug	Miconazole [22916-47-8]; Up 200; 9.6uM; MCF7; HT_HG-U133A	NR4A3 IRS2 KLF4 BAHCC1	6.67e-05	180	28	4	1477_UP
Drug	Doxorubicin hydrochloride [25316-40-9]; Down 200; 6.8uM; PC3; HT_HG-U133A	IRS2 AMOTL2 FOXA2 KLF4	7.26e-05	184	28	4	4610_DN
Drug	Progesterone [57-83-0]; Down 200; 12.8uM; PC3; HT_HG-U133A	RERE KLF4 ATXN7L1 SF3A2	8.74e-05	193	28	4	6646_DN
Drug	ICI 182,780; Down 200; 1uM; PC3; HT_HG-U133A	KLF4 ATXN7L1 SF3A2 TLE1	8.91e-05	194	28	4	4429_DN
Drug	Aconitine [302-27-2]; Up 200; 6.2uM; MCF7; HT_HG-U133A	DVL3 IRS2 RERE ATXN7L1	8.91e-05	194	28	4	2776_UP
Drug	STOCK1N-35215; Down 200; 10uM; PC3; HT_HG-U133A	RERE TLE1 FUBP1 IQSEC2	8.91e-05	194	28	4	6380_DN
Drug	aspirin, USP; Down 200; 100uM; PC3; HT_HG-U133A	IRS2 RERE KLF4 IQSEC2	9.09e-05	195	28	4	4428_DN
Drug	troglitazone; Up 200; 10uM; PC3; HG-U133A	NR4A3 IRS2 FOXA2 TLE1	9.09e-05	195	28	4	431_UP
Drug	Paclitaxel [33069-62-4]; Up 200; 4.6uM; MCF7; HT_HG-U133A	KLF4 SF3A2 TLE1 BAHCC1	9.28e-05	196	28	4	5320_UP
Drug	Esculetin [305-01-1]; Up 200; 22.4uM; MCF7; HT_HG-U133A	IRS2 TLE1 FUBP1 BAHCC1	9.46e-05	197	28	4	7459_UP
Drug	DMEP	NBL1 RERE	9.55e-05	12	28	2	CID000008344
Drug	Tolfenamic acid [13710-19-5]; Up 200; 15.2uM; MCF7; HT_HG-U133A	IRS2 RERE TLE1 IQSEC2	1.00e-04	200	28	4	5454_UP
Disease	Polyarthritis, Juvenile, Rheumatoid Factor Positive	NR4A3 RERE KLF4	2.58e-04	131	28	3	C4704862
Disease	Polyarthritis, Juvenile, Rheumatoid Factor Negative	NR4A3 RERE KLF4	2.58e-04	131	28	3	C4552091
Disease	Juvenile arthritis	NR4A3 RERE KLF4	2.58e-04	131	28	3	C3495559
Disease	Juvenile psoriatic arthritis	NR4A3 RERE KLF4	2.58e-04	131	28	3	C3714758
Disease	Juvenile-Onset Still Disease	NR4A3 RERE KLF4	2.82e-04	135	28	3	C0087031
Disease	cervical cancer (is_implicated_in)	SF3B4 KMT2E	3.72e-04	30	28	2	DOID:4362 (is_implicated_in)
Disease	hepatocellular carcinoma (is_implicated_in)	SF3B4 KLF4 FUBP1	6.64e-04	181	28	3	DOID:684 (is_implicated_in)
Disease	interleukin 12 measurement	KLF4 KCNC3	1.16e-03	53	28	2	EFO_0004753
Disease	Insulin Sensitivity	NR4A3 IRS2	1.49e-03	60	28	2	C0920563
Disease	Insulin Resistance	NR4A3 IRS2	1.49e-03	60	28	2	C0021655
Disease	dentures	RARB BAHCC1	2.02e-03	70	28	2	EFO_0010078
Disease	dental caries, dentures	RARB BAHCC1	2.02e-03	70	28	2	EFO_0003819, EFO_0010078
Disease	hepatocellular carcinoma (is_marker_for)	SF3B4 KLF4 FUBP1	2.85e-03	301	28	3	DOID:684 (is_marker_for)
Disease	diastolic blood pressure, systolic blood pressure	KMT2E PHGR1 RBM33 ZIC5	3.50e-03	670	28	4	EFO_0006335, EFO_0006336
Disease	Neurodevelopmental Disorders	KMT2E IQSEC2	3.52e-03	93	28	2	C1535926
Disease	eosinophil percentage of leukocytes	NR4A3 RERE RARB ATXN7L1	5.12e-03	746	28	4	EFO_0007991
Disease	RS-warfarin measurement	RARB KLF4	6.56e-03	128	28	2	EFO_0803325
Disease	cup-to-disc ratio measurement	RERE RARB AMOTL2	7.68e-03	430	28	3	EFO_0006939

Protein segments in the cluster

Peptide	Gene	Start	Entry
HPPPPHPAALGHGPL	AMOTL2	271	Q9Y2J4
QLGGDPAPHTHPHPP	BAHCC1	806	Q9P281
SHHTHPSYGPPGVPP	DVL3	646	Q92997
HSGHTPEPPLPPVGG	ATXN7L1	416	Q9ULK2
HLPAGPHAHSPVPPG	RBM33	1036	Q96EV2
LSLPPLHGLHGHPPP	RARB	36	P10826
HLHTHPPGPGPPLQG	OCEL1	71	Q9H607
HPALPLPPGFHPHPG	KLF4	331	O43474
PPVPHGPHGVPGPHG	FUBP1	456	Q96AE4
HTPHSPLPPTSPHGP	IQSEC2	1446	Q5JU85
PLPPTSPHGPLHASG	IQSEC2	1451	Q5JU85
PAPHHHPPPHPSTGL	KMT2E	1686	Q8IZD2
GPGSQPGTHPHPHPH	NBL1	141	P41271
PGTHPHPHPHPHPGG	NBL1	146	P41271
HPHPHPHPGGQTPEP	NBL1	151	P41271
CGGHGHPPGHCGPPP	PHGR1	11	C9JFL3
HGGPPVTAPPPHHYN	CBLL1	411	Q75N03
HPPLPHPLHHGPGQR	IRS2	466	Q9Y4H2
GHGVGPHQHSGPAPP	EGLN1	66	Q9GZT9
AAHLLGPPHHPGLPP	FOXA2	346	Q9Y261
GPPHHPGLPPEAHLK	FOXA2	351	Q9Y261
SPPHPPAPSPAGGHH	NR4A3	196	Q92570
HQHQHHPPGPGQPSP	SOX17	321	Q9H6I2
HAQPPLHGQGPPGPH	RERE	841	Q9P2R6
HPPAPGVHPPTSGVH	SF3A2	316	Q15428
HPPAPGVHPPAPGVH	SF3A2	351	Q15428
HPQAPGVHPQPPGVH	SF3A2	401	Q15428
PHPGGHPHSSPLAPH	SLX4	1346	Q8IY92
GPGLSTPGGHPKPPH	SFPQ	221	P23246
GHGPPVPLTPHPSGL	TLE1	136	Q04724
HPVGGHPAPPHPHGG	ZNF517	126	Q6ZMY9
HPAPPHPHGGPEDGS	ZNF517	131	Q6ZMY9
PGHGHSHPHPFPPGG	SF3B4	286	Q15427
PHGLGHPHAGPPGSG	SF3B4	316	Q15427
PALHDTPGAPGGHPH	ZIC5	261	Q96T25
PPPPPHPHHGSGGIS	KCNC3	581	Q14003
HPHHGSGGISPPPPI	KCNC3	586	Q14003