Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionRoundabout binding

LRTM2 SLIT1 LGR6

1.20e-04121673GO:0048495
GeneOntologyMolecularFunctiondenatured protein binding

HSPA1A HSPA1B

2.07e-0431672GO:0031249
GeneOntologyMolecularFunctionprotein-containing complex destabilizing activity

IQCA1L HSPA1A HSPA1B

2.43e-04151673GO:0140776
GeneOntologyMolecularFunctionprotein phosphatase 2A binding

AKAP6 VIM MFHAS1 ANKLE2

4.12e-04421674GO:0051721
GeneOntologyMolecularFunctionminus-end-directed microtubule motor activity

DNHD1 DNAH3 DNAH10

4.27e-04181673GO:0008569
GeneOntologyCellularComponentcell-cell contact zone

AKAP6 PKP4 PCDHA10 YWHAH SPTBN4 CTNNA3 SCRIB

1.09e-05941687GO:0044291
GeneOntologyCellularComponentinner dynein arm

DNHD1 DNAH3 DNAH10

5.87e-05101683GO:0036156
GeneOntologyCellularComponentcell leading edge

VIM CARMIL2 DOCK8 AAK1 GDPD2 ADGRE2 DYSF CTNNA3 TRPV2 SCRIB EXOC4 PLCE1 PSD4

2.10e-0450016813GO:0031252
DomainARM-like

ZYG11A DOCK8 MROH2A PKP4 SARM1 CKAP5 TSC2 CUL7 KIFAP3 NF1 PKP3 AP5Z1 AP1G2 ULK4 ZER1 SERAC1 AP4B1 TBCD XPOT

4.64e-1227016819IPR011989
DomainLRR_TYP

MFHAS1 PIDD1 LRRC40 LINGO2 LRTM2 TLR8 LRRC46 OPTC LRRIQ1 TLR2 SLIT1 LRRC1 TLR5 LRRC26 LGR6 SCRIB

5.64e-1217716816SM00369
DomainLeu-rich_rpt_typical-subtyp

MFHAS1 PIDD1 LRRC40 LINGO2 LRTM2 TLR8 LRRC46 OPTC LRRIQ1 TLR2 SLIT1 LRRC1 TLR5 LRRC26 LGR6 SCRIB

5.64e-1217716816IPR003591
Domain-

ZYG11A CARMIL2 MFHAS1 PIDD1 LRRC40 LINGO2 LRTM2 TLR8 LRRC46 OPTC LRRIQ1 TLR2 SLIT1 LRRC1 TLR5 TONSL LRRC26 ZER1 LGR6 SCRIB

1.14e-11321168203.80.10.10
DomainL_dom-like

ZYG11A CARMIL2 MFHAS1 PIDD1 LRRC40 LINGO2 LRTM2 TLR8 LRRC46 OPTC LRRIQ1 TLR2 SLIT1 LRRC1 TLR5 TONSL LRRC26 ZER1 LGR6 SCRIB

1.69e-1132816820IPR032675
Domain-

ZYG11A PKP4 SARM1 CKAP5 TSC2 CUL7 KIFAP3 NF1 PKP3 AP5Z1 AP1G2 ULK4 ZER1 SERAC1 AP4B1 TBCD XPOT

1.72e-11222168171.25.10.10
DomainLeu-rich_rpt

CARMIL2 MFHAS1 PIDD1 LRRC40 LINGO2 LRTM2 TLR8 LRRC46 OPTC LRRIQ1 TLR2 SLIT1 LRRC1 TLR5 TONSL LRRC26 LGR6 SCRIB

4.56e-1127116818IPR001611
DomainLRR_1

MFHAS1 PIDD1 LRRC40 LINGO2 LRTM2 TLR8 LRRC46 OPTC LRRIQ1 TLR2 SLIT1 LRRC1 TLR5 LRRC26 LGR6 SCRIB

1.41e-1021916816PF00560
DomainARM-type_fold

ZYG11A DOCK8 MROH2A PKP4 SARM1 INTS1 CKAP5 TSC2 CUL7 KIFAP3 NF1 PKP3 AP1G2 ULK4 ZER1 SERAC1 AP4B1 TBCD XPOT

2.36e-1033916819IPR016024
DomainLRR

MFHAS1 PIDD1 LRRC40 LINGO2 LRTM2 TLR8 LRRC46 OPTC LRRIQ1 TLR2 SLIT1 LRRC1 TLR5 LGR6 SCRIB

4.05e-1020116815PS51450
DomainLRR_8

MFHAS1 PIDD1 LRRC40 LINGO2 LRTM2 TLR8 OPTC TLR2 SLIT1 LRRC1 TLR5 LRRC26 LGR6 SCRIB

4.71e-1017116814PF13855
DomainCys-rich_flank_reg_C

LINGO2 LRTM2 TLR8 TLR2 SLIT1 TLR5 LRRC26

1.68e-05901687IPR000483
DomainLRRCT

LINGO2 LRTM2 TLR8 TLR2 SLIT1 TLR5 LRRC26

1.68e-05901687SM00082
DomainTIR

SARM1 TLR8 TLR2 TLR5

3.35e-05211684SM00255
Domain-

SARM1 TLR8 TLR2 TLR5

4.89e-052316843.40.50.10140
DomainTIR

SARM1 TLR8 TLR2 TLR5

5.83e-05241684PS50104
DomainTIR_dom

SARM1 TLR8 TLR2 TLR5

6.89e-05251684IPR000157
DomainDynein_HC_stalk

DNHD1 DNAH3 DNAH10

2.42e-04141683IPR024743
DomainDynein_heavy_dom-2

DNHD1 DNAH3 DNAH10

2.42e-04141683IPR013602
DomainDHC_N2

DNHD1 DNAH3 DNAH10

2.42e-04141683PF08393
DomainATPase_dyneun-rel_AAA

DNAH3 DNAH10 MDN1

2.42e-04141683IPR011704
DomainMT

DNHD1 DNAH3 DNAH10

2.42e-04141683PF12777
DomainAAA_5

DNAH3 DNAH10 MDN1

2.42e-04141683PF07728
DomainLRRNT

LINGO2 LRTM2 OPTC SLIT1 LRRC26 LGR6

2.57e-04981686IPR000372
DomainLRRNT

LINGO2 LRTM2 OPTC SLIT1 LRRC26 LGR6

2.57e-04981686SM00013
DomainDHC_fam

DNHD1 DNAH3 DNAH10

3.00e-04151683IPR026983
DomainDynein_heavy

DNHD1 DNAH3 DNAH10

3.00e-04151683PF03028
DomainDynein_heavy_dom

DNHD1 DNAH3 DNAH10

3.00e-04151683IPR004273
DomainAAA

DNAH3 DNAH10 NVL AK9 ABCB4 MDN1 ABCC8

3.29e-041441687SM00382
DomainAAA+_ATPase

DNAH3 DNAH10 NVL AK9 ABCB4 MDN1 ABCC8

3.29e-041441687IPR003593
DomainARM_REPEAT

PKP4 KIFAP3 PKP3 ZER1

4.48e-04401684PS50176
DomainARM

PKP4 KIFAP3 PKP3 ZER1

4.48e-04401684SM00185
DomainRCC1

RCCD1 NEK8 HERC1

7.28e-04201683PF00415
DomainArmadillo

PKP4 KIFAP3 PKP3 ZER1

8.33e-04471684IPR000225
DomainRCC1_1

RCCD1 NEK8 HERC1

8.44e-04211683PS00625
DomainRCC1_2

RCCD1 NEK8 HERC1

8.44e-04211683PS00626
DomainRCC1_3

RCCD1 NEK8 HERC1

8.44e-04211683PS50012
Domain-

RCCD1 NEK8 HERC1

9.71e-042216832.130.10.30
DomainReg_chr_condens

RCCD1 NEK8 HERC1

9.71e-04221683IPR000408
DomainTIR

TLR8 TLR2 TLR5

9.71e-04221683PF01582
DomainRCC1/BLIP-II

RCCD1 NEK8 HERC1

1.11e-03231683IPR009091
DomainLRRNT

LINGO2 LRTM2 SLIT1 LGR6

1.31e-03531684PF01462
Domain-

TOM1 RPRD1A HGS

1.60e-032616831.25.40.90
Domain14_3_3

YWHAG YWHAH

1.64e-0371682SM00101
Domain1433_1

YWHAG YWHAH

1.64e-0371682PS00796
Domain1433_2

YWHAG YWHAH

1.64e-0371682PS00797
Domain14-3-3_domain

YWHAG YWHAH

1.64e-0371682IPR023410
Domain14-3-3_CS

YWHAG YWHAH

1.64e-0371682IPR023409
Domain14-3-3

YWHAG YWHAH

1.64e-0371682PF00244
DomainPlakophilin/d_Catenin

PKP4 PKP3

1.64e-0371682IPR028435
Domain14-3-3

YWHAG YWHAH

2.17e-0381682IPR000308
DomainENTH_VHS

TOM1 RPRD1A HGS

2.20e-03291683IPR008942
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

MFHAS1 KHNYN INTS1 ADGRL1 TSC2 DYSF BIRC6 KMT2C CELSR1 MDN1 RPAP1 SGSM2 NEK8 AP1G2 ULK4 ZER1 ZFYVE26 ULK1 STK40 HERC1 TBCD

1.64e-0711051732135748872
Pubmed

E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.

DNAH3 CEP290 INTS1 CKAP5 PIDD1 LRRC40 TSC2 FAM186B BIRC6 KMT2C MDN1 ADO RPAP1 BTD BOD1L1 SCRIB LONRF2

1.85e-077361731729676528
Pubmed

SARM1 and TRAF6 bind to and stabilize PINK1 on depolarized mitochondria.

VIM SARM1 HSPA1A HSPA1B

1.90e-0711173423885119
Pubmed

CTDP1 regulates breast cancer survival and DNA repair through BRCT-specific interactions with FANCI.

INTS1 TSC2 CRACD NF1 MDN1 TBCD XPOT

9.45e-07104173731240132
Pubmed

Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.

TPR VIM DOCK8 VPS33A INTS1 CKAP5 LRRC40 TRAP1 NF1 MDN1 PKP3 LRRC1 SCRIB EXOC4

1.46e-065821731420467437
Pubmed

Binding specificity of Toll-like receptor cytoplasmic domains.

TLR8 TRAP1 TLR2 TLR5

2.16e-0619173416482509
Pubmed

Phosphorylation and binding partner analysis of the TSC1-TSC2 complex.

TSC2 HSPA1A HSPA1B

2.39e-066173315963462
Pubmed

Toll-like receptor 2 expression on c-kit+ cells tracks the emergence of embryonic definitive hematopoietic progenitors.

SARM1 TLR8 TLR2 TLR5

4.03e-0622173431729371
Pubmed

Multiplex screening of 22 single-nucleotide polymorphisms in 7 Toll-like receptors: an association study in rheumatoid arthritis.

TLR8 TLR2 TLR5

4.17e-067173320194452
Pubmed

Comparative interactome analysis of α-arrestin families in human and Drosophila.

ZSWIM8 ECD TFIP11 TSC2 CUL7 NF1 ANKIB1 BOD1L1 SCRIB XPOT

4.21e-063131731038270169
Pubmed

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.

PKP4 TFIP11 COLGALT1 RRBP1 MAP3K6 RPAP1 TONSL MARF1 ANKIB1 ULK1 SCRIB AP4B1 EXOC4 PLCE1

5.20e-066501731438777146
Pubmed

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.

VIM PKP4 CEP290 COLGALT1 CUL7 ANKLE2 BIRC6 YWHAG MTMR10 YWHAH NUDT5 TTC7B HGS LRRC1 PDP2 SCRIB HERC1 XPOT

5.50e-0610491731827880917
Pubmed

Defining the membrane proteome of NK cells.

CARMIL2 DOCK8 CEP290 INTS1 CKAP5 NVL LRRC40 COLGALT1 ANKLE2 BIRC6 YWHAG TRAP1 SLC44A1 NF1 MDN1 MAP4K1 MARF1 EXOC4 PSD4

6.37e-0611681731919946888
Pubmed

Spatacsin regulates directionality of lysosome trafficking by promoting the degradation of its partner AP5Z1.

YWHAH AP5Z1 ZFYVE26

6.65e-068173337871017
Pubmed

Age-associated decrease in TLR function in primary human dendritic cells predicts influenza vaccine response.

TLR8 TLR2 TLR5

6.65e-068173320100933
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

KHNYN CKAP5 ADGRL1 CRACD RPAP1 SGSM2 SLIT1 BOD1L1 ULK1 SCRIB PLCE1

6.82e-064071731112693553
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

AKAP6 VIM ZSWIM8 CEP290 CKAP5 TFIP11 TSC2 RRBP1 YWHAG MTMR10 YWHAH SPTBN4 RPRD1A TTC7B SGSM2 SCRIB HSPA1A HSPA1B EXOC4 XPOT

6.87e-0612851732035914814
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

VIM CARMIL2 AAK1 CKAP5 TSC2 MAP3K6 YWHAG YWHAH NF1 MDN1 SAMD11 MAP4K1 BOD1L1 SCRIB BRD1 EXOC4

7.03e-068611731636931259
Pubmed

Fibril treatment changes protein interactions of tau and α-synuclein in human neurons.

TPR VIM VPS33A SARM1 INTS1 AAK1 CARS1 YWHAH CRACD BOD1L1 SCRIB TBCD

8.25e-064981731236634849
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

VIM CARMIL2 DOCK8 PKP4 TOM1 AAK1 CKAP5 ADGRL1 RRBP1 YWHAG YWHAH SPTBN4 NDUFA13 CRACD SLC44A1 NF1 TTC7B SCRIB HSPA1A HSPA1B EXOC4

9.73e-0614311732137142655
Pubmed

Chromosomal localization of five murine HSP70 gene family members: Hsp70-1, Hsp70-2, Hsp70-3, Hsc70t, and Grp78.

VIM HSPA1A HSPA1B

9.94e-06917338486356
Pubmed

14-3-3 interacts with the tumor suppressor tuberin at Akt phosphorylation site(s).

TSC2 YWHAG YWHAH

9.94e-069173312438239
Pubmed

Identification and characterization of the interaction between tuberin and 14-3-3zeta.

TSC2 YWHAG YWHAH

9.94e-069173312176984
Pubmed

Polymorphism in 3'-untranslated region of toll-like receptor 4 gene is associated with protection from hepatitis B virus recurrence after liver transplantation.

TLR8 TLR2 TLR5

9.94e-069173320977567
Pubmed

Regulation of angiogenesis, mural cell recruitment and adventitial macrophage behavior by Toll-like receptors.

TLR8 TLR2 TLR5

9.94e-069173324091496
Pubmed

Polymorphisms in innate immunity genes associated with development of bronchiolitis obliterans after lung transplantation.

TLR8 TLR2 TLR5

1.41e-0510173320227302
Pubmed

A family of human receptors structurally related to Drosophila Toll.

TLR8 TLR2 TLR5

1.41e-051017339435236
Pubmed

[Expression of toll-like receptors in human epidermal keratinocytes].

TLR8 TLR2 TLR5

1.41e-0510173318686608
Pubmed

Toll-like receptors.

TLR8 TLR2 TLR5

1.41e-0510173311782555
Pubmed

Triad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptors.

UBE2L6 TLR2 TLR5

1.94e-0511173315107846
Pubmed

Toll-like receptors.

TLR8 TLR2 TLR5

1.94e-0511173318394314
Pubmed

Exercise induces hepatosplanchnic release of heat shock protein 72 in humans.

HSPA1A HSPA1B

2.46e-052173212411538
Pubmed

Molecular cloning and analysis of DNA complementary to three mouse Mr = 68,000 heat shock protein mRNAs.

HSPA1A HSPA1B

2.46e-05217322868009
Pubmed

Up-regulation of inducible heat shock protein-70 expression in multiple sclerosis patients.

HSPA1A HSPA1B

2.46e-052173224328534
Pubmed

A novel pathway of rapid TLR-triggered activation of integrin-dependent leukocyte adhesion that requires Rap1 GTPase.

TLR2 TLR5

2.46e-052173225057020
Pubmed

In vitro transcription of a human hsp 70 heat shock gene by extracts prepared from heat-shocked and non-heat-shocked human cells.

HSPA1A HSPA1B

2.46e-05217323786141
Pubmed

Senescence-Associated Secretory Phenotype Suppression Mediated by Small-Sized Mesenchymal Stem Cells Delays Cellular Senescence through TLR2 and TLR5 Signaling.

TLR2 TLR5

2.46e-052173233401590
Pubmed

Characterization of the binding between a 70-kDa heat shock protein, HspA1A, and phosphoinositides.

HSPA1A HSPA1B

2.46e-052173226923070
Pubmed

Surface expression of HSP72 by LPS-stimulated neutrophils facilitates gammadeltaT cell-mediated killing.

HSPA1A HSPA1B

2.46e-052173216482515
Pubmed

Effect of hyaluronan oligosaccharides on the expression of heat shock protein 72.

HSPA1A HSPA1B

2.46e-052173211864979
Pubmed

Hippocampal 72-kDa heat shock protein expression varies according to mice learning performance independently from chronic exposure to stress.

HSPA1A HSPA1B

2.46e-052173215719414
Pubmed

Hsp70 protects from stroke in atrial fibrillation patients by preventing thrombosis without increased bleeding risk.

HSPA1A HSPA1B

2.46e-052173226976620
Pubmed

Targeting membrane heat-shock protein 70 (Hsp70) on tumors by cmHsp70.1 antibody.

HSPA1A HSPA1B

2.46e-052173221187371
Pubmed

Radiation therapy induces circulating serum Hsp72 in patients with prostate cancer.

HSPA1A HSPA1B

2.46e-052173220430459
Pubmed

The Tumor Suppressor SCRIB is a Negative Modulator of the Wnt/β-Catenin Signaling Pathway.

LRRC1 SCRIB

2.46e-052173231513346
Pubmed

Astrocyte targeted overexpression of Hsp72 or SOD2 reduces neuronal vulnerability to forebrain ischemia.

HSPA1A HSPA1B

2.46e-052173220235222
Pubmed

Genetic determinants of HSP70 gene expression following heat shock.

HSPA1A HSPA1B

2.46e-052173220876613
Pubmed

The C-terminal BAG domain of BAG5 induces conformational changes of the Hsp70 nucleotide-binding domain for ADP-ATP exchange.

HSPA1A HSPA1B

2.46e-052173220223214
Pubmed

Membrane-associated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mouse and human myeloid-derived suppressor cells.

HSPA1A HSPA1B

2.46e-052173220093776
Pubmed

Bacterial infection elicits heat shock protein 72 release from pleural mesothelial cells.

HSPA1A HSPA1B

2.46e-052173223704948
Pubmed

Structure and expression of the human gene encoding major heat shock protein HSP70.

HSPA1A HSPA1B

2.46e-05217322858050
Pubmed

Nuclear heat shock protein 72 as a negative regulator of oxidative stress (hydrogen peroxide)-induced HMGB1 cytoplasmic translocation and release.

HSPA1A HSPA1B

2.46e-052173217513788
Pubmed

IL-6 activates HSP72 gene expression in human skeletal muscle.

HSPA1A HSPA1B

2.46e-052173212207910
Pubmed

Inducing heat shock protein 70 expression provides a robust antithrombotic effect with minimal bleeding risk.

HSPA1A HSPA1B

2.46e-052173228837204
Pubmed

Genetic variants of toll-like receptor 2 and 5, helicobacter pylori infection, and risk of gastric cancer and its precursors in a chinese population.

TLR2 TLR5

2.46e-052173221994405
Pubmed

Concurrent action of purifying selection and gene conversion results in extreme conservation of the major stress-inducible Hsp70 genes in mammals.

HSPA1A HSPA1B

2.46e-052173229572464
Pubmed

Protective effect of heat shock proteins 70.1 and 70.3 on retinal photic injury after systemic hyperthermia.

HSPA1A HSPA1B

2.46e-052173215988927
Pubmed

Impaired mitochondrial dynamics underlie axonal defects in hereditary spastic paraplegias.

AP5Z1 ZFYVE26

2.46e-052173229726929
Pubmed

Microbial patterns signaling via Toll-like receptors 2 and 5 contribute to epithelial repair, growth and survival.

TLR2 TLR5

2.46e-052173218167552
Pubmed

Hsp70 (HSPA1) Lysine Methylation Status as a Potential Prognostic Factor in Metastatic High-Grade Serous Carcinoma.

HSPA1A HSPA1B

2.46e-052173226448330
Pubmed

Activation of TLR2 and TLR5 did not affect tumor progression of an oral squamous cell carcinoma, YD-10B cells.

TLR2 TLR5

2.46e-052173220456615
Pubmed

HSP70.1 and -70.3 are required for late-phase protection induced by ischemic preconditioning of mouse hearts.

HSPA1A HSPA1B

2.46e-052173212714332
Pubmed

Inflammation-induced, 3'UTR-dependent translational inhibition of Hsp70 mRNA impairs intestinal homeostasis.

HSPA1A HSPA1B

2.46e-052173219299581
Pubmed

Insights into regulation and function of the major stress-induced hsp70 molecular chaperone in vivo: analysis of mice with targeted gene disruption of the hsp70.1 or hsp70.3 gene.

HSPA1A HSPA1B

2.46e-052173211713291
Pubmed

Heat shock protein 72 (Hsp72) improves long term recovery after focal cerebral ischemia in mice.

HSPA1A HSPA1B

2.46e-052173221108992
Pubmed

Prion disease is accelerated in mice lacking stress-induced heat shock protein 70 (HSP70).

HSPA1A HSPA1B

2.46e-052173231320473
Pubmed

Cloning and characterization of two Toll/Interleukin-1 receptor-like genes TIL3 and TIL4: evidence for a multi-gene receptor family in humans.

TLR2 TLR5

2.46e-05217329596645
Pubmed

Dual-vector gene therapy restores cochlear amplification and auditory sensitivity in a mouse model of DFNB16 hearing loss.

STRC STRCP1

2.46e-052173234910522
Pubmed

hsp72, a host determinant of measles virus neurovirulence.

HSPA1A HSPA1B

2.46e-052173216971451
Pubmed

M2BP inhibits HIV-1 virion production in a vimentin filaments-dependent manner.

VIM LGALS3BP

2.46e-052173227604950
Pubmed

Heat shock protein 70 promotes lipogenesis in HepG2 cells.

HSPA1A HSPA1B

2.46e-052173229631603
Pubmed

Coordinated post-transcriptional regulation of Hsp70.3 gene expression by microRNA and alternative polyadenylation.

HSPA1A HSPA1B

2.46e-052173221757701
Pubmed

Extracellular heat shock protein 70 induces cardiomyocyte inflammation and contractile dysfunction via TLR2.

TLR2 HSPA1B

2.46e-052173221817814
Pubmed

Role of membrane Hsp70 in radiation sensitivity of tumor cells.

HSPA1A HSPA1B

2.46e-052173226197988
Pubmed

Acquired Cystic Kidney Disease-associated Renal Cell Carcinoma (ACKD-RCC) Harbor Recurrent Mutations in KMT2C and TSC2 Genes.

TSC2 KMT2C

2.46e-052173232604168
Pubmed

Hsp72 overexpression accelerates the recovery from caerulein-induced pancreatitis.

HSPA1A HSPA1B

2.46e-052173222792201
Pubmed

Inhibition of hsp70-1 and hsp70-3 expression disrupts preimplantation embryogenesis and heightens embryo sensitivity to arsenic.

HSPA1A HSPA1B

2.46e-05217329820195
Pubmed

Surface expression of a C-terminal alpha-helix region in heat shock protein 72 on murine LL/2 lung carcinoma can be recognized by innate immune sentinels.

HSPA1A HSPA1B

2.46e-052173219157555
Pubmed

Heat Shock Protein 70 Is Involved in the Efficiency of Preconditioning with Cyclosporine A in Renal Ischemia Reperfusion Injury by Modulating Mitochondrial Functions.

HSPA1A HSPA1B

2.46e-052173237298493
Pubmed

Genetic manipulation of cardiac Hsp72 levels does not alter substrate metabolism but reveals insights into high-fat feeding-induced cardiac insulin resistance.

HSPA1A HSPA1B

2.46e-052173225618331
Pubmed

Extracellular heat shock protein 72 is a marker of the stress protein response in acute lung injury.

HSPA1A HSPA1B

2.46e-052173216679378
Pubmed

Pseudomonas aeruginosa flagella activate airway epithelial cells through asialoGM1 and toll-like receptor 2 as well as toll-like receptor 5.

TLR2 TLR5

2.46e-052173214607814
Pubmed

Inducible 70 kDa heat shock proteins protect embryos from teratogen-induced exencephaly: Analysis using Hspa1a/a1b knockout mice.

HSPA1A HSPA1B

2.46e-052173219639652
Pubmed

Effect of mutation of amino acids 246-251 (KRKHKK) in HSP72 on protein synthesis and recovery from hypoxic injury.

HSPA1A HSPA1B

2.46e-052173216100242
Pubmed

Role of the C-terminal region of mouse inducible Hsp72 in the recognition of peptide substrate for chaperone activity.

HSPA1A HSPA1B

2.46e-052173215498567
Pubmed

Biological activity of truncated C-terminus human heat shock protein 72.

HSPA1A HSPA1B

2.46e-052173221094186
Pubmed

Toll-like receptor 5 and 8 in hepatocellular carcinoma.

TLR8 TLR5

2.46e-052173233950532
Pubmed

Endogenous TLR2 ligand embedded in the catalytic region of human cysteinyl-tRNA synthetase 1.

CARS1 TLR2

2.46e-052173232461342
Pubmed

A dominant vimentin mutant upregulates Hsp70 and the activity of the ubiquitin-proteasome system, and causes posterior cataracts in transgenic mice.

VIM HSPA1B

2.46e-052173218940912
Pubmed

Exercise-induced extracellular 72 kDa heat shock protein (Hsp72) stimulates neutrophil phagocytic and fungicidal capacities via TLR-2.

TLR2 HSPA1A

2.46e-052173219771447
Pubmed

Geranylgeranylaceton induces heat shock protein 72 in skeletal muscle cells.

HSPA1A HSPA1B

2.46e-052173217482577
Pubmed

Structure and expression of an inducible HSP70-encoding gene from Mus musculus.

HSPA1A HSPA1B

2.46e-05217328076831
Pubmed

The 70 kDa heat shock protein protects against experimental traumatic brain injury.

HSPA1A HSPA1B

2.46e-052173223816752
Pubmed

Mutations in the planar cell polarity genes CELSR1 and SCRIB are associated with the severe neural tube defect craniorachischisis.

CELSR1 SCRIB

2.46e-052173222095531
Pubmed

The association of 14-3-3gamma and actin plays a role in cell division and apoptosis in astrocytes.

YWHAG YWHAH

2.46e-052173212176032
Pubmed

Mucoid Pseudomonas aeruginosa caused by mucA mutations result in activation of TLR2 in addition to TLR5 in airway epithelial cells.

TLR2 TLR5

2.46e-052173223068105
Pubmed

Mutations in a new gene encoding a protein of the hair bundle cause non-syndromic deafness at the DFNB16 locus.

STRC STRCP1

2.46e-052173211687802
Pubmed

PKA phosphorylation and 14-3-3 interaction regulate the function of neurofibromatosis type I tumor suppressor, neurofibromin.

YWHAH NF1

2.46e-052173214741381
Pubmed

Vimentin regulates scribble activity by protecting it from proteasomal degradation.

VIM SCRIB

2.46e-052173219386766
Pubmed

Structure of a new crystal form of human Hsp70 ATPase domain.

HSPA1A HSPA1B

2.46e-052173210216320
InteractionBAG2 interactions

UBE2L6 MFHAS1 POT1 AAK1 CKAP5 LRRC40 CUL7 HPSE LGALS3BP RPAP1 AP5Z1 HGS BOD1L1 STK40 BRD1 HSPA1A HSPA1B TBCD

3.34e-0662216418int:BAG2
InteractionMTCL2 interactions

VIM ESR2 VPS33A TFIP11 YWHAG YWHAH DNAJB13 BRD1

4.29e-061141648int:MTCL2
InteractionCEP131 interactions

VIM ESR2 POT1 CEP290 VPS33A YWHAG YWHAH DNAJB13 RHOBTB1 BRCA2

5.77e-0620016410int:CEP131
InteractionLIMD1 interactions

VIM ESR2 VPS33A MAP3K6 YWHAG YWHAH BRCA2 HSPA1A

8.02e-061241648int:LIMD1
InteractionPTPRN2 interactions

CKAP5 ANKLE2 SPTBN4 SGSM2 HGS XPOT

2.87e-05731646int:PTPRN2
InteractionCNPY3 interactions

LRRC40 LINGO2 COLGALT1 TLR8 LRRC1 TLR5 BOD1L1 SCRIB XPOT

3.35e-051961649int:CNPY3
InteractionRTKN interactions

MFHAS1 ESR2 YWHAG YWHAH NF1 ADO MAST3

4.36e-051151647int:RTKN
InteractionDISC1 interactions

AKAP6 CEP290 TFIP11 RRBP1 YWHAG GATAD2B SPTBN4 KIFAP3 ADO CTNNA3 AP4B1 BRD1 EXOC4

5.14e-0542916413int:DISC1
InteractionTXNIP interactions

TPR ZSWIM8 ESR2 ECD GATAD2B SCARA5 SCRIB HSPA1A HSPA1B

6.17e-052121649int:TXNIP
InteractionNEK1 interactions

MFHAS1 CEP290 TSC2 YWHAG YWHAH SCRIB

6.38e-05841646int:NEK1
InteractionCT55 interactions

VIM VPS33A TFIP11 BRCA2 SAMD11

6.41e-05521645int:CT55
InteractionBPIFB4 interactions

BRCA2 BPIFB4

6.58e-0521642int:BPIFB4
InteractionUBA1 interactions

UBE2L6 DOCK8 ESR2 CEP290 NVL COLGALT1 CUL7 YWHAG YWHAH BTD HGS HSPA1A

6.80e-0538016412int:UBA1
InteractionYWHAG interactions

VIM CARMIL2 UBE2L6 ESR2 POT1 AAK1 CKAP5 TSC2 CUL7 MAP3K6 YWHAG YWHAH CRACD NF1 MDN1 SAMD11 BOD1L1 ULK1 SCRIB BRD1 HSPA1A MAST3 EXOC4 PSD4

7.46e-05124816424int:YWHAG
InteractionPPP5C interactions

VIM DCPS ESR2 BIRC6 DNAJB13 MAP4K1 LRRC1 BRD1 HSPA1A HSPA1B

8.06e-0527216410int:PPP5C
InteractionLPP interactions

VIM ESR2 POT1 YWHAH RHOBTB1 SCRIB HSPA1A

8.20e-051271647int:LPP
InteractionCLTC interactions

VIM PKP4 VPS33A TOM1 AAK1 CKAP5 COLGALT1 CUL7 YWHAG RHOBTB1 PKP3 HGS MARF1 HERC1 BRD1 HSPA1A

9.21e-0565516416int:CLTC
InteractionCCDC8 interactions

TPR MROH2A CEP290 INTS1 CKAP5 LRRC40 CUL7 YWHAG YWHAH LGALS3BP TRAP1 NF1 MDN1 RPAP1 PKP3 SCRIB

9.37e-0565616416int:CCDC8
InteractionBRCC3 interactions

ESR2 POT1 VPS33A YWHAG YWHAH BRCA2 HSPA1A

1.05e-041321647int:BRCC3
GeneFamilyCD molecules|Toll like receptors

TLR8 TLR2 TLR5

2.35e-05101073948
GeneFamilyZYG11 cell cycle regulator family

ZYG11A ZER1

1.04e-04310726
GeneFamily14-3-3 phospho-serine/phospho-threonine binding proteins

YWHAG YWHAH

7.15e-04710721053
GeneFamilyGlycosyl transferases group 1 domain containing

GTDC1 GYS2

1.51e-03101072427
CoexpressionGSE27241_WT_VS_RORGT_KO_TH17_POLARIZED_CD4_TCELL_TREATED_WITH_DIGOXIN_UP

DOCK8 CKAP5 TSC2 BIRC6 KMT2C NF1 TTC7B ULK1 HERC1

3.13e-061801729M8239
ToppCell(05)_Ciliated-(4)_1wkpi|(05)_Ciliated / shred by cell type and Timepoint

DNAH10 AK9 RPAP1 BRCA2 AP5Z1 TRPV2 NOCT HSPA1A HSPA1B

3.79e-08180173985fc9b164147b28545e2397d32302eea03ef6346
ToppCellnormal_Pleural_Fluid-B_lymphocytes-Plasma_cells|B_lymphocytes / Location, Cell class and cell subclass

VPS37A MFHAS1 LRRC40 RRBP1 LGALS3BP KIFAP3 SLC44A1 SERAC1

1.56e-071531738a156710217ef07c07a80ca6504fa0784d86380fa
ToppCell368C-Myeloid-Dendritic-pDC|368C / Donor, Lineage, Cell class and subclass (all cells)

FAAH RPAP1 MAP4K1 NEK8 TONSL LRRC26 ANKIB1 BORA

3.06e-0716717381e2fc1637769405a61f4c7e44945712a1888a299
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DNAH3 DNAH10 AK9 LRRC46 LRRIQ1 SLIT1 AGBL2 SEC14L4

3.35e-07169173814aadc2d1bf66eb47dac33b4d61ddb3c942caa4f
ToppCellNS-moderate-d_16-33-Epithelial-Ciliated|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

AKAP6 DNAH3 DNAH10 DNAJB13 LRRC46 LRRIQ1 AGBL2 SEC14L4

6.65e-0718517385e689c2fb36ce3ac2adc8d15f67107f21cf68868
ToppCelldroplet-Lung-nan-18m-Mesenchymal-Airway_Smooth_Muscle|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AKAP6 GDPD2 TCAP OPTC CTNNA3 LGR6 HSPA1A HSPA1B

7.51e-07188173861f010c165826b434ca3d27553d4c9e13d2c0c51
ToppCelldroplet-Lung-nan-18m-Mesenchymal-bronchial_smooth_muscle_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AKAP6 GDPD2 TCAP OPTC CTNNA3 LGR6 HSPA1A HSPA1B

7.51e-0718817387553ef7de3575af4cf34704b405b551c1af8eb83
ToppCellPND01-Epithelial-Epithelial_Airway|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

DNAH3 DNAH10 C16orf96 AK9 LRRC46 LRRIQ1 LRRC26 AGBL2

7.82e-07189173838cde34295566a4ecaf7d0a81c5a192cf17d0459
ToppCellPND01-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

DNAH3 DNAH10 C16orf96 AK9 DNAJB13 LRRC46 LRRIQ1 AGBL2

8.46e-07191173896483adb97c81208aa513782550acd8a08b63866
ToppCellmoderate-Myeloid-Monocyte-derived_Macrophage|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

UBE2L6 RRBP1 LGALS3BP APOBEC3A GBP4 TRPV2 HSPA1A HSPA1B

9.15e-07193173822455801194bd8c73c5c397f5eac4f723429c383
ToppCellwk_20-22-Epithelial-Proximal_epithelial-MUC16+_ciliated|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

DNAH3 DNAH10 DNAJB13 LRRC46 CELSR1 LRRIQ1 AGBL2 MUC4

9.52e-071941738756082a0f5953b52229bb60d40b84701cb6cb23d
ToppCellBiopsy_Control_(H.)-Epithelial-Differentiating_Ciliated|Biopsy_Control_(H.) / Sample group, Lineage and Cell type

DNAH3 DNAH10 DNAJB13 LRRC46 LRRIQ1 LRRC26 MUC4 PLCE1

1.20e-062001738a552a99f5e4fa00dfb7775e5a3e1f62f1530d104
ToppCellBiopsy_IPF|World / Sample group, Lineage and Cell type

DNAH3 DNAH10 DNAJB13 LRRC46 LRRIQ1 LRRC26 AGBL2 MUC4

1.20e-0620017384de8c4789fb64250cb1dca94c108d39ab119bab4
ToppCellfacs-Heart-RV-3m-Lymphocytic-T_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FAAH PRR7 SAMD11 MAP4K1 PKP3 EDARADD AP1G2

3.99e-061661737c0fd3f3f5c3412746da279b856af0d28b9b70c5d
ToppCellfacs-Heart-RV-3m-Lymphocytic-T_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FAAH PRR7 SAMD11 MAP4K1 PKP3 EDARADD AP1G2

3.99e-061661737ac9b9df57d65ccbbf9ae3add50c5663efcd30dcb
ToppCellmetastatic_Lymph_Node-Myeloid_cells-pDCs|metastatic_Lymph_Node / Location, Cell class and cell subclass

DCPS SCARA5 NEK8 SLIT1 LRRC26 NR5A1 LONRF2

4.85e-0617117371f8e66073088fc1969782e443bf00f8c1877ea91
ToppCellwk_20-22-Epithelial-Proximal_epithelial-Deuterosomal|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

ZYG11A DNAH10 MROH2A AK9 LRRC46 LRRIQ1 LRRC26

4.85e-06171173752aec5f6677fe2f7a36fb5b18117a4cffaeff58f
ToppCelldroplet-Skin-nan-18m-Lymphocytic-nan|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AKAP6 VIM STARD8 HPSE PRR7 LGALS3BP TRPV2

6.32e-06178173712d5c6be6cfbf733e3cb02780606b3725eda7d2b
ToppCelldroplet-Skin-nan-18m-Lymphocytic-T_cell|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AKAP6 VIM STARD8 HPSE PRR7 LGALS3BP TRPV2

6.32e-061781737e0769ad06f92423a3cb6c78a61da3ba5bd9b4eae
ToppCelldroplet-Skin-nan-18m-Lymphocytic|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AKAP6 VIM STARD8 HPSE PRR7 LGALS3BP TRPV2

6.32e-06178173711c2ce093b7538518c8d4497dc5b0b4da22bf1a8
ToppCellE17.5-Epithelial-airway_epithelial_cell|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

DNAH3 AK9 BARX2 DNAJB13 LRRC46 LRRIQ1 LRRC26

7.57e-06183173707cebb0e186e1bff14ac2a6bb6f8412d4aaa2350
ToppCellE17.5-Epithelial-airway_epithelial_cell-club_cell|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

DNAH3 AK9 BARX2 DNAJB13 LRRC46 LRRIQ1 LRRC26

7.57e-061831737e8e85e5be909f9cd85a6a041190bfcb855dfa1a4
ToppCellP07-Epithelial-airway_epithelial_cell|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

DNAH3 DNAH10 AK9 BARX2 DNAJB13 LRRIQ1 LRRC26

7.84e-061841737a5e7af3392e9d6ddad0397f1eeb6b91ed1107cc2
ToppCellP07-Epithelial-airway_epithelial_cell-club_cell|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

DNAH3 DNAH10 AK9 BARX2 DNAJB13 LRRIQ1 LRRC26

7.84e-061841737ab469b9e06212462cbe2e4db8775c6778db855e6
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

GABRB2 MFHAS1 PKP4 FAM83E NEK8 TLR2 LONRF2

7.84e-0618417378fd8bd3d28d0ee6f0ef1f14e354d8eaf63a8081b
ToppCell15-Airway-Epithelial-Multiciliated_cell|Airway / Age, Tissue, Lineage and Cell class

DNAH3 DNAH10 DNAJB13 LRRC46 LRRIQ1 AGBL2 SEC14L4

8.13e-0618517370998b6bf44287eebbf39249fff23fc3689e44c4e
ToppCellP28-Epithelial-airway_epithelial_cell-club_cell|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

DNAH3 DNAH10 AK9 BARX2 DNAJB13 LRRC46 LRRIQ1

8.42e-061861737a26811481668fa25c48a064a56c198685693ad8d
ToppCellP28-Epithelial-airway_epithelial_cell|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

DNAH3 DNAH10 AK9 BARX2 DNAJB13 LRRC46 LRRIQ1

8.42e-061861737df80f101954b8ec6ccdb03e702de22e70b65181f
ToppCellTCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-1|TCGA-Pancreas / Sample_Type by Project: Shred V9

TPR BIRC6 CRACD ARHGAP6 NSUN3 MARF1 BOD1L1

8.42e-06186173703db813598b67b1e08f759758a1c2023396921fa
ToppCelldroplet-Lung-18m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l39|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

AKAP6 TCAP OPTC CTNNA3 LGR6 HSPA1A HSPA1B

8.72e-061871737218c9b4f28499389c43005d9626af2ac01066027
ToppCelldroplet-Lung-18m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

AKAP6 TCAP OPTC CTNNA3 LGR6 HSPA1A HSPA1B

8.72e-061871737c7ac4b328efc2ebb72f71154661914193ff402ca
ToppCellPND07-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated-Ciliated_mature|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

DNAH3 DNAH10 C16orf96 AK9 DNAJB13 LRRC46 LRRIQ1

9.34e-061891737057d7a03fdbe779122b203619a6f947f49b84d28
ToppCellPND01-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated-Ciliated_mature|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

DNAH3 C16orf96 AK9 DNAJB13 LRRC46 LRRIQ1 AGBL2

9.34e-061891737b55de812043b670cbde810d7d42f45909b6d66ef
ToppCellfacs-Heart-RA-24m-Mesenchymal-ventricular_myocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AKAP6 CACNA2D2 KLHL31 CRACD ABCC8 CTNNA3 LGR6

9.34e-061891737e758b264c0a47127e33e66c395cf5a3224c7305b
ToppCellfacs-Trachea-24m-Epithelial-airway_epithelial-respiratory_basal_cell-basal_epithelial_cell_of_trachea|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FAM83E GDPD2 BARX2 CELSR1 LRRC26 HSPA1B MUC4

9.34e-061891737ee15b4fb3a1cfda80bcf210a23f04f242594015e
ToppCellfacs-Trachea-24m-Epithelial-airway_epithelial-respiratory_basal_cell|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FAM83E GDPD2 BARX2 CELSR1 LRRC26 HSPA1B MUC4

9.34e-061891737dc6f6fae84347d145bea71b49eaeeb3028e9c4ae
ToppCellfacs-Heart-RA-24m-Mesenchymal-ventricular_cardiomyocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AKAP6 CACNA2D2 KLHL31 CRACD ABCC8 CTNNA3 LGR6

9.34e-061891737b98f60875b1a12b2ec9dc91889298ae57f98602f
ToppCellPND07-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

DNAH3 DNAH10 C16orf96 AK9 DNAJB13 LRRC46 LRRIQ1

9.34e-0618917379f57a131902d23494bf389baf6e6e2d99f88b2c8
ToppCelldroplet-Marrow-nan-3m-Hematologic-erythroblast|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MFHAS1 CEP290 ABCB4 CRACD BRCA2 SAMD11 LONRF2

9.34e-0618917378a38baee58a27c2fa3f4bd131ab9f15723ed9295
ToppCellPND01-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

DNAH3 C16orf96 AK9 DNAJB13 LRRC46 LRRIQ1 AGBL2

9.34e-0618917374e83e49d1265ffe507fdb72924c77c4d1c73f0bd
ToppCellPND07-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

DNAH3 DNAH10 C16orf96 AK9 DNAJB13 LRRC46 LRRIQ1

9.34e-061891737e443b02502edaefa94567a9e8af5756e8e11ff30
ToppCellSevere-Lymphoid-NK-Treg|Severe / Condition, Lineage, Cell class and cell subclass

NAALADL1 POT1 SARM1 NVL PIDD1 TRAP1 TONSL

9.67e-061901737e67803bf55a3f8e47a69ff1829c9100f870d7527
ToppCellPND07-Epithelial-Epithelial_Airway|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

DNAH3 DNAH10 C16orf96 AK9 DNAJB13 LRRIQ1 LRRC26

1.00e-051911737b55500eb416f4f339031acad16b2737e5b891d8e
ToppCelldroplet-Heart-nan-24m-Mesenchymal-cardiomyocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AKAP6 CACNA2D2 TCAP KLHL31 CRACD ABCC8 CTNNA3

1.03e-051921737f6a4e348406a852ace9fb21db8fbdff539217645
ToppCellPND03-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

DNAH3 CEP290 AK9 DNAJB13 LRRC46 LRRIQ1 AGBL2

1.03e-051921737b5cdc2dae3154b1e4ade88f841f38584402ffe33
ToppCelldroplet-Heart-nan-24m-Mesenchymal-atrial_cardiomyocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AKAP6 CACNA2D2 TCAP KLHL31 CRACD ABCC8 CTNNA3

1.03e-0519217371a0c25106ae08eac912a4edd5fc1a3ee776f69c2
ToppCellPND03-Epithelial-Epithelial_Airway|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

DNAH3 CEP290 AK9 DNAJB13 LRRC46 LRRIQ1 AGBL2

1.03e-0519217372d8d5a38e205339eda9c8aca1ca9ba3dcbe5ae56
ToppCellIPF-Epithelial-Ciliated|Epithelial / Disease state, Lineage and Cell class

AKAP6 DNAH3 DNAH10 AK9 LRRC46 LRRIQ1 ULK4

1.07e-051931737ad58f5080e0ba65c845056ea6b79037b636e9c64
ToppCellPosterior_cortex-Neuronal|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

GABRB2 CARMIL2 AAK1 YWHAG SPTBN4 HERC1 LONRF2

1.07e-051931737b4989e3436e84dbec3789b46057e0f7a0ebf09d4
ToppCellHippocampus-Neuronal|Hippocampus / BrainAtlas - Mouse McCarroll V32

GABRB2 AAK1 ADGRL1 YWHAG SPTBN4 KIFAP3 HERC1

1.11e-0519417378aeb347b3024354c9505f4f0fddf0b843489dc6b
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

AKAP6 DNAH3 DNAH10 AK9 LRRIQ1 ULK4 MUC4

1.11e-0519417374a2c127c90d1fefe604fcb9e796577d21b489dd6
ToppCell3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

AKAP6 DNAH3 DNAH10 CEP290 AK9 LRRIQ1 ULK4

1.22e-05197173774a2c6cb8fcfe53dd9a2b36492a16c58f38e51c9
ToppCellLPS_anti-TNF-Epithelial_alveolar-AT_1-Differentiating_AT2|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

SLC22A23 CEP290 RRBP1 CHKA FAAH CELSR1 AP1G2

1.22e-0519717373d13a4f2e86422900ee2194e8a1fd1cf9750d5d3
ToppCellBronchial-NucSeq-Epithelial-Epi_airway_neuro-secretory-Ionocyte_n_Brush|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

GABRB2 CUL7 NDUFA13 EDARADD LRRC26 SCRIB SLC4A9

1.26e-051981737dd0465b45b02cb8edf0914d19afb52fcaaeb012c
ToppCellnormal_Pleural_Fluid-B_lymphocytes-Plasma_cells|normal_Pleural_Fluid / Location, Cell class and cell subclass

MFHAS1 LRRC40 RRBP1 KIFAP3 SERAC1 PLCE1

1.30e-0513217364e37400ae7375e6986f060234c373194603346f8
ToppCellBronchial-10x5prime-Epithelial-Epi_airway_ciliated-Deuterosomal|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

DNAH3 DNAH10 LRRC46 LRRIQ1 LRRC26 AGBL2 PLCE1

1.31e-05199173792778939e9d06599c7d06cfd8f4362b97ed0606b
ToppCellLPS_only-Epithelial_alveolar-AT_1-Differentiating_AT1|LPS_only / Treatment groups by lineage, cell group, cell type

SLC22A23 CEP290 FAM83E FAAH PKP3 AP1G2 STRC

1.35e-0520017372dadf317a42a7e27cc1fac74f91b806c93a57108
ToppCellTracheal-NucSeq-Epithelial-Epi_airway_ciliated-Ciliated|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

DNAH3 DNAH10 DNAJB13 LRRC46 LRRIQ1 AGBL2 SEC14L4

1.35e-052001737af6a551f83808c1c839df7ba7b1702ca28ea6e1b
ToppCellTracheal-NucSeq-Epithelial-Epi_airway_ciliated|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

DNAH3 DNAH10 DNAJB13 LRRC46 LRRIQ1 AGBL2 SEC14L4

1.35e-05200173773ac1cf40ddd764be1100cbfaaa29563665457d8
ToppCellPosterior_cortex-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Sst-Inhibitory_Neuron.Gad1Gad2.Sst-Pdyn_(Neuron.Gad1Gad2.Sst-Pdyn)|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

MROH2A HPSE IQCA1L EDARADD

1.56e-053917348b5d15f979a92799a9e77f1b501d3c4fa4e8695a
ToppCellPosterior_cortex-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Sst-Inhibitory_Neuron.Gad1Gad2.Sst-Pdyn_(Neuron.Gad1Gad2.Sst-Pdyn)-|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

MROH2A HPSE IQCA1L EDARADD

1.56e-05391734a24eb4c26344c5c97bbf39a1adc56ee34013dc4f
ToppCellLPS-IL1RA-Epithelial_airway-Ciliated_cells|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DNAH3 DNAH10 BARX2 DNAJB13 LRRC46 LRRIQ1

2.78e-05151173681cf939ed4df9574fbfff265e109cb9f947d7e6e
ToppCellLPS-IL1RA-Epithelial_airway-Ciliated_cells-Ciliated|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DNAH3 DNAH10 BARX2 DNAJB13 LRRC46 LRRIQ1

2.78e-0515117369cbcbbc22965a9f0be8364e733d205dd64f2a533
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FAM83E ABCC8 CTNNA3 LGR6 ANO3 PLCE1

2.89e-051521736bd1f36b436d8ab7dd8420f595b97d851eab31a38
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FAM83E ABCC8 CTNNA3 LGR6 ANO3 PLCE1

2.89e-051521736ee329249a034a969a16b26a224aa04249d67382d
ToppCellBAL-Mild-Myeloid-MoAM-MoAM2|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ADGRE2 DYSF HPSE APOBEC3A HSPA1A HSPA1B

3.00e-0515317365fbb90b8477f9fdabf3be19efd3068fbf70abee6
ToppCellBAL-Mild-Myeloid-MoAM-MoAM2-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

ADGRE2 DYSF HPSE APOBEC3A HSPA1A HSPA1B

3.00e-0515317362c46183481e6d5a7fa190a743062509465f88e56
ToppCellBAL-Mild-Myeloid-MoAM-MoAM2|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

ADGRE2 DYSF HPSE APOBEC3A HSPA1A HSPA1B

3.00e-051531736decc4f3098a9374a6b65c015a9d36380986290bf
ToppCellBAL-Mild-Myeloid-MoAM-MoAM2-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ADGRE2 DYSF HPSE APOBEC3A HSPA1A HSPA1B

3.00e-05153173636a28805c0545c2f410c74a6ca0a70d840e75715
ToppCell390C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_3|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)

KHNYN SPTBN4 SCARA5 PKP3 AP5Z1 TLR5

3.11e-0515417361c62290a2558fd6401b27de5a867d243b143b00a
ToppCellLPS-IL1RA+antiTNF-Epithelial_airway-Ciliated_cells|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DNAH3 DNAH10 BARX2 DNAJB13 LRRC46 LRRIQ1

3.22e-0515517365f1e2195a6b831e1b636f5cc3a282ca423721822
ToppCellLPS-IL1RA+antiTNF-Epithelial_airway-Ciliated_cells-Ciliated|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DNAH3 DNAH10 BARX2 DNAJB13 LRRC46 LRRIQ1

3.22e-0515517360944429459f642a1bcc56edc1ec28aaecde3e2dc
ToppCelldroplet-Liver-LIVER_NPC-30m-Myeloid-myeloid_leukocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PIDD1 SERPINB10 MAP4K1 PKP3 BPIFB4 HSPA1A

3.59e-05158173690ca742739a208d457db087655ba3d1c18a9da57
ToppCelldroplet-Liver-LIVER_NPC-30m-Myeloid-macrophage/monocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VIM SERPINB10 MAP4K1 PKP3 BPIFB4 HSPA1A

3.85e-0516017368dae9b0cf90a09acb196223f45a14680102630b2
ToppCellfacs-Brain_Myeloid-Cerebellum-24m-Myeloid-macrophage|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VIM ADGRE2 HPSE SERPINB10 MAP4K1 PKP3

3.85e-0516017361f7acdc8b08152d5817fc53bbf47b4a22d9c91b5
ToppCellfacs-Lung-EPCAM-3m-Lymphocytic-CD8-positive,_alpha-beta_T_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SARM1 FAAH EDARADD TONSL ZFYVE26 PSD4

3.99e-0516117368e787cc7f5e818cad1a6ed143a5fe310993e030b
ToppCellfacs-Lung-EPCAM-3m-Lymphocytic-CD8+_T|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SARM1 FAAH EDARADD TONSL ZFYVE26 PSD4

3.99e-051611736ca9233370490e27b9a1892669d6b82db2136180e
ToppCellMild_COVID-19-Myeloid-MoAM2|Mild_COVID-19 / Disease group,lineage and cell class (2021.01.30)

ADGRE2 DYSF HPSE APOBEC3A HSPA1A HSPA1B

4.13e-051621736e5fc80ab19d513af6a7e677a5e67bfebca2e963b
ToppCell368C-Lymphocytic-CD4_T-cell-Treg_cell_4|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

MFHAS1 C16orf96 TTC7B GBP4 ZFYVE26 XPOT

4.13e-05162173664353d33af0e82ebb7cf2bba74d52ca0586a58fc
ToppCell368C-Lymphocytic-CD4_T-cell-Treg_cell_4|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)

MFHAS1 C16orf96 TTC7B GBP4 ZFYVE26 XPOT

4.27e-0516317369f5facfa1864eb63e2f8022ad7379d9252b7a254
ToppCellLPS-IL1RA+antiTNF-Epithelial_airway|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DNAH3 BARX2 DNAJB13 LRRC46 LRRIQ1 ANO3

4.42e-051641736e4d4c59aebe5cacd4ecdb907facd044dc82a831d
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Outer_Medullary_Collecting_Duct_Intercalated_Cell_Type_A|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK8 SLC22A23 EDARADD LONRF2 MUC4 SLC4A9

5.22e-0516917362a21f2cef959526bfe3c8f081f4f7e9dd4e01a37
ToppCell5'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DNAH3 DNAH10 C16orf96 AK9 LRRIQ1 ULK4

5.22e-051691736fba841664939c771881ba97f14ef1df6635c04ff
ToppCelldroplet-Liver-LIVER_NPC-30m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AKAP6 DOCK8 FAM83E LRRC26 HSPA1B MUC4

5.40e-051701736a121e10099faaeb60251eec162f38caf7c4238c2
ToppCellfacs-Lung-EPCAM-3m-Epithelial-club_cell_of_bronchiole|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CARMIL2 PRSS36 NSUN3 LRRIQ1 LRRC26 SEC14L4

5.40e-05170173682ccba6ec53f6ca0d19949a1277434c565af2983
ToppCellfacs-Lung-EPCAM-3m-Epithelial-Club_Cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CARMIL2 PRSS36 NSUN3 LRRIQ1 LRRC26 SEC14L4

5.40e-051701736ab19ea729ed8c8361c870e79893d1a95a1e487fa
ToppCelldroplet-Lung-30m-Hematologic-lymphocytic-CD4-positive,_alpha-beta_T_cell-CD4-positive,_alpha-beta_T_cell_l9|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CARMIL2 SARM1 CELSR1 GBP4 PKP3 MUC4

5.40e-051701736d74fbd995a8a37fc237f7147d398357b811d6452
ToppCell3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DNAH3 DNAJB13 CELSR1 SGSM2 SCRIB AGBL2

5.58e-0517117361854a777d9eb9d3fc3ed3632332a6f89ce8131da
ToppCell368C-Myeloid-Dendritic-pDC|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

FAAH RPAP1 MAP4K1 NEK8 LRRC26 ANKIB1

5.58e-051711736714a0b0d0c9886fef64170cf53eb64f0d8a47280
ToppCellfacs-Heart-Unknown-3m-Mesenchymal-atrial_myocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AKAP6 TCAP KLHL31 CRACD ABCC8 CTNNA3

5.76e-051721736ee8ce9e8c9a6d3ee2be113f77743958005f4b3f0
ToppCelldroplet-Lung-3m-Hematologic-lymphocytic-regulatory_T_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

IGFLR1 FAAH GBP4 SAMD11 MAP4K1 ABCC8

5.76e-051721736425970e9ce8943f7e2ba6ca958e7a3a29baa798c
ToppCelldroplet-Lung-3m-Hematologic-lymphocytic-regulatory_T_cell-regulatory_T_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

IGFLR1 FAAH GBP4 SAMD11 MAP4K1 ABCC8

5.76e-051721736ca0cc0e92b6cdce5016f18fcb2ec1508cb222502
ToppCellfacs-Heart-Unknown-3m-Mesenchymal-atrial_cardiomyocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AKAP6 TCAP KLHL31 CRACD ABCC8 CTNNA3

5.76e-051721736bd468a7ea6ec832dcf6a816a1e0c03fa0f176dad
ToppCellfacs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PKP4 GDPD2 ULK4 HERC1 MUC4 XPOT

6.14e-051741736f1fe1f4216748a9562dd03bd48c70b23c7ff4d1d
ToppCellPCW_10-12-Epithelial-Epithelial_ciliated|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

DNAH3 DNAH10 DNAJB13 LRRC46 LRRC26 SEC14L4

6.14e-051741736b8d1c556290d188f56aeefc17f03119686945fe7
ToppCell(03)_Secretory-(0)_uninjured|(03)_Secretory / shred by cell type and Timepoint

SLC22A23 GDPD2 LGALS3BP ARHGAP6 LGR6 SEC14L4

6.14e-051741736ebdddb5091afcc49ab533c890f260f709880c5f9
ToppCellPCW_10-12-Epithelial-Epithelial_ciliated-epi_ciliated_(14)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

DNAH3 DNAH10 DNAJB13 LRRC46 LRRC26 SEC14L4

6.14e-05174173600cf27bc23af1472a507be31fba6245a8fdd901b
ToppCellfacs-Lung-ENDOMUCIN-18m-Lymphocytic-CD8-positive,_alpha-beta_T_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CARMIL2 IGFLR1 FAM186B PKP3 TONSL PSD4

6.34e-051751736a72c6ceca5ddbd34f652e7302defefa2d105e17e
ToppCellfacs-Lung-ENDOMUCIN-18m-Lymphocytic-CD8+_T|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CARMIL2 IGFLR1 FAM186B PKP3 TONSL PSD4

6.34e-0517517369a462e9e6f7bbb64abb09ad6c080df3576073540
ToppCell5'-Adult-SmallIntestine-Hematopoietic-T_cells-SELL+_CD4_T|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RSAD1 HPSE KLHL31 MAP4K1 TRPV2 HSPA1A

6.54e-051761736ac83a6cd4bcbb9ca1fc02a9fbd9d9629ef1df8ca
Drug6-Hydroxytropinone [5932-53-6]; Down 200; 25.8uM; MCF7; HT_HG-U133A

CEP290 VPS33A ADGRL1 ZNF623 FAAH BRCA2 BTD NOCT BRD1 PSD4

2.17e-06196169107346_DN
DrugArtemisinin [63968-64-9]; Up 200; 14.2uM; MCF7; HT_HG-U133A

VIM PIDD1 ADGRL1 GTDC1 DYSF NF1 AP5Z1 ZER1 ZFYVE26 TBCD

2.60e-06200169107007_UP
DrugDemeclocycline hydrochloride [64-73-3]; Down 200; 8uM; MCF7; HT_HG-U133A

PIDD1 DYSF FAAH SLC44A1 NF1 PKP3 TLR2 MAST3 PSD4

1.52e-0519416993604_DN
DrugICI 182,780; Down 200; 0.01uM; HL60; HT_HG-U133A

ZSWIM8 VPS33A AAK1 PIDD1 ZNF623 RPAP1 AP5Z1 ULK1 PSD4

1.52e-0519416991179_DN
DrugAmpicillin trihydrate [7177-48-2]; Down 200; 10uM; MCF7; HT_HG-U133A

GABRB2 UBE2L6 AAK1 PIDD1 ADGRL1 TLR5 ZER1 ZFYVE26 NOCT

1.79e-0519816991530_DN
DrugIobenguane sulfate; Down 200; 10.8uM; MCF7; HT_HG-U133A

ZSWIM8 VPS33A ADGRL1 TFIP11 LGALS3BP NF1 SGSM2 AP5Z1 PSD4

1.86e-0519916996002_DN
Drugclozapine; Down 200; 10uM; MCF7; HG-U133A

GABRB2 ZSWIM8 DYSF HPSE NF1 BTD TLR5 ZFYVE26 PSD4

1.94e-052001699416_DN
Diseaseautosomal recessive nonsyndromic deafness 16 (implicated_via_orthology)

STRC STRCP1

3.22e-0521682DOID:0110471 (implicated_via_orthology)
DiseaseMalignant neoplasm of breast

AKAP6 VIM STARD8 RCCD1 ESR2 DYSF HPSE MAP3K6 FAAH APOBEC3A SLC22A9 NF1 RPRD1A BRCA2 ZFYVE26 BOD1L1 LGR6 HSPA1B

4.41e-05107416818C0006142
DiseaseColorectal Carcinoma

AKAP6 DNAH3 STARD8 ESR2 ABCB4 SLC22A9 KMT2C NF1 RPAP1 ABCC8 TLR2 LGR6 LONRF2 EXOC4

5.29e-0570216814C0009402
Diseasehigh grade glioma (is_implicated_in)

POT1 SLC44A1 NF1 BRCA2

9.59e-05421684DOID:3070 (is_implicated_in)
Diseasegonadal dysgenesis (implicated_via_orthology)

STARD8 NR5A1

1.92e-0441682DOID:14447 (implicated_via_orthology)
DiseaseConventional (Clear Cell) Renal Cell Carcinoma

DNHD1 PIDD1 TSC2 CUL7 SPTBN4 MUC4

2.11e-041481686C0279702
Diseaseobsolete_red blood cell distribution width

VIM CARMIL2 RCCD1 DOCK8 SLC22A23 KHNYN NVL AK9 IGFLR1 BIRC6 PRSS36 APOBEC3A ABCB4 NDUFA13 HERC1 MUC4 SEC14L4 MAST3 BORA

2.55e-04134716819EFO_0005192
Diseasegraft-versus-host disease (biomarker_via_orthology)

HSPA1A HSPA1B

3.19e-0451682DOID:0081267 (biomarker_via_orthology)
Diseasesystemic lupus erythematosus (is_implicated_in)

VIM ESR2 TLR5 HSPA1A

4.37e-04621684DOID:9074 (is_implicated_in)
Diseaseurinary tract infection (is_implicated_in)

TLR2 HSPA1B

4.76e-0461682DOID:0080784 (is_implicated_in)
DiseaseCUB domain-containing protein 1 measurement

DCPS SARM1

6.64e-0471682EFO_0802432
Diseasemicrocephaly (implicated_via_orthology)

CARS1 CHKA ANKLE2

7.96e-04321683DOID:10907 (implicated_via_orthology)
DiseaseSarcomatoid Renal Cell Carcinoma

DNHD1 PIDD1 CUL7 SPTBN4 MUC4

8.48e-041281685C1266043
DiseaseChromophobe Renal Cell Carcinoma

DNHD1 PIDD1 CUL7 SPTBN4 MUC4

8.48e-041281685C1266042
DiseaseCollecting Duct Carcinoma of the Kidney

DNHD1 PIDD1 CUL7 SPTBN4 MUC4

8.48e-041281685C1266044
DiseasePapillary Renal Cell Carcinoma

DNHD1 PIDD1 CUL7 SPTBN4 MUC4

8.48e-041281685C1306837
DiseaseRenal Cell Carcinoma

DNHD1 PIDD1 CUL7 SPTBN4 MUC4

8.48e-041281685C0007134
DiseaseNEURAL TUBE DEFECTS, SUSCEPTIBILITY TO

CELSR1 SCRIB

8.82e-0481682C3891448
Diseasebenign neoplasm (implicated_via_orthology)

LRRC1 SCRIB

8.82e-0481682DOID:0060072 (implicated_via_orthology)
Diseasehealth study participation

SLC22A23 BIRC6 ADO CTNNA3 MAST3 EXOC4

9.08e-041951686EFO_0010130
DiseaseMajor depression, single episode

HSPA1A HSPA1B

1.13e-0391682C0024517
Diseasemedulloblastoma (is_implicated_in)

TSC2 BRCA2

1.41e-03101682DOID:0050902 (is_implicated_in)
Diseaseotitis media (is_marker_for)

TLR2 MUC4

1.41e-03101682DOID:10754 (is_marker_for)
Diseasedescending aortic diameter

SPTBN4 ABCC8 ULK4 PLCE1

1.63e-03881684EFO_0021788
Diseasekidney cancer (implicated_via_orthology)

LRRC1 SCRIB

1.71e-03111682DOID:263 (implicated_via_orthology)
Diseaseaseptic loosening, revision of total knee arthroplasty

LINGO2 CTNNA3 PSD4

1.77e-03421683EFO_0010725, EFO_0020972
Diseaseattention deficit hyperactivity disorder, autism spectrum disorder, intelligence

AKAP6 CACNA2D2 SLC22A23 DYSF GATAD2B LONRF2 MAST3 EXOC4

2.09e-033981688EFO_0003756, EFO_0003888, EFO_0004337
Diseasemultiple myeloma, monoclonal gammopathy

TOM1 ULK4

2.80e-03141682EFO_0000203, EFO_0001378
DiseaseAutosomal recessive limb-girdle muscular dystrophy

DYSF TCAP

2.80e-03141682cv:C2931907
Diseaserisky sexual behaviour measurement

LINGO2 BIRC6 NSUN3 SGSM2 MAST3

2.88e-031691685EFO_0007877
Diseasemelanoma

POT1 DCBLD1 HPSE NF1 BRCA2 HSPA1A

3.06e-032481686C0025202
DiseaseNephrosis

VIM HPSE

3.22e-03151682C0027720
DiseaseMammary Carcinoma, Human

VIM STARD8 RCCD1 ESR2 HPSE APOBEC3A BRCA2 LGR6 HSPA1B

3.26e-035251689C4704874
DiseaseMammary Neoplasms, Human

VIM STARD8 RCCD1 ESR2 HPSE APOBEC3A BRCA2 LGR6 HSPA1B

3.26e-035251689C1257931
DiseaseMammary Neoplasms

VIM STARD8 RCCD1 ESR2 HPSE APOBEC3A BRCA2 LGR6 HSPA1B

3.35e-035271689C1458155
Diseaseatherosclerosis (is_implicated_in)

VIM HSPA1A

3.67e-03161682DOID:1936 (is_implicated_in)
DiseaseBreast Carcinoma

VIM STARD8 RCCD1 ESR2 HPSE APOBEC3A BRCA2 LGR6 HSPA1B

3.83e-035381689C0678222
Diseasecoffee consumption measurement

AKAP6 CACNA2D2 LINGO2 BIRC6 FAAH

3.95e-031821685EFO_0006781
DiseaseDystonia, Limb

SERAC1 ANO3

4.14e-03171682C0751093
DiseaseDystonia, Diurnal

SERAC1 ANO3

4.14e-03171682C0393610
Diseaseperinatal necrotizing enterocolitis (biomarker_via_orthology)

TLR2 TLR5

4.14e-03171682DOID:8677 (biomarker_via_orthology)
DiseaseIntellectual Disability

AKAP6 GABRB2 DOCK8 YWHAG KMT2C NF1 SERAC1 TBCD

4.23e-034471688C3714756
Diseasecognitive function measurement, self reported educational attainment

AKAP6 CACNA2D2 GTDC1 BIRC6 GATAD2B LONRF2 EXOC4

4.36e-033551687EFO_0004784, EFO_0008354
DiseaseDystonia, Paroxysmal

SERAC1 ANO3

4.64e-03181682C0393588
DiseaseFebrile seizure (within the age range of 3 months to 6 years)

HERC1 ANO3

4.64e-03181682HP_0002373
DiseaseColorectal Neoplasms

STARD8 ESR2 ABCB4 ABCC8 TLR2 LGR6

5.22e-032771686C0009404
Diseaseatrial fibrillation

AKAP6 DNAH10 ESR2 DCBLD1 SLIT1 CTNNA3 HERC1

5.53e-033711687EFO_0000275

Protein segments in the cluster

PeptideGeneStartEntry
EVPQARLLGLNELDD

PKP4

756

Q99569
TELNEPLSNEERNLL

YWHAG

31

P61981
LRDLLVAANPDLLQQ

ACTL10

56

Q5JWF8
ESLSPELRGQLQALL

SLC4A9

161

Q96Q91
PLTVLLRSVLDQLQD

BRD1

566

O95696
DALLARLKLLNPDDL

ANKLE2

66

Q86XL3
ESLLNLLDNLLSPLQ

BIRC6

2136

Q9NR09
IEQSLPNERFEELLL

BLACE

156

A4D250
QDALLRPLELENDTV

CACNA2D2

806

Q9NY47
TELNEPLSNEDRNLL

YWHAH

31

Q04917
PNLARSLLLVDQLID

AAK1

946

Q2M2I8
IQSILQALDELLEAP

ADGRE2

301

Q9UHX3
DNLVNRVLADVLPDL

BPIFB4

316

P59827
SLLTQLRAEDLNIAP

ADO

56

Q96SZ5
AELRFLDLVPSLQLD

APOBEC3A

71

P31941
LDILDAQLQALRPIE

ADGRL1

581

O94910
LLRALATNPNLTALD

CARMIL2

601

Q6F5E8
DALLRGEIPDLNDIL

GYS2

406

P54840
NLQEKLALRLDLPES

ARGFX

106

A6NJG6
TEPQASQLLDLLDLL

AP1G2

616

O75843
QPRSEEELFDILNLL

AP4B1

226

Q9Y6B7
EDDPNILLAIQLSLQ

ANKIB1

851

Q9P2G1
LDLPCLTAVLDLQLR

AP5Z1

471

O43299
NELRLLLLDPATGEL

CELSR1

1146

Q9NYQ6
QLSRDLDNNRPLEAL

CELSR1

1161

Q9NYQ6
KNLQLLSEESELRLP

FAM186B

671

Q8IYM0
ALALPDLRQVAELTL

DNHD1

1826

Q96M86
LRADDPLLKLLQEAQ

DCPS

321

Q96C86
LDLSPDQLDQLLQEA

ECD

416

O95905
PLLALLNNIIEIRLD

ANO3

776

Q9BYT9
EAELEPRLLEALQGL

RCCD1

196

A6NED2
DELQRLLGLLRDQDP

NVL

526

O15381
LLGLLRDQDPLSEEQ

NVL

531

O15381
LPLRVIQLLLSEEEN

MUC4

5171

Q99102
LNAASLLPVLALELR

NSUN3

116

Q9H649
INELLIDDDLQLPSE

KLHL31

216

Q9H511
RPLLLDLLERNAEAI

MDN1

66

Q9NU22
LEALNRLLDDNRELL

MDN1

1161

Q9NU22
LLLEEQPLLLQDLLD

KMT2C

3046

Q8NEZ4
RELLLDALSPEQLVL

ESR2

256

Q92731
TDLLQLLLPRSDLAV

LGALS3BP

301

Q08380
FPRQLLQLVALEELD

MFHAS1

196

Q9Y4C4
LVDAALQDLEPQQLL

INTS1

1231

Q8N201
ISDQELLPRRNSLIL

MTMR10

596

Q9NXD2
ELPSLQSLRLDANLI

LGR6

136

Q9HBX8
QSLRLDANLISLVPE

LGR6

141

Q9HBX8
NRLLPAADLLEDQEL

HERC1

1096

Q15751
QRLPELLTERQLDLG

DCAF12L2

81

Q5VW00
LLCSQADLPDLQALR

MAP3K6

146

O95382
ENVQDLLLLDVAPLS

HSPA1B

386

P0DMV9
LEDIRLDGNPINLSL

OPTC

301

Q9UBM4
ISLPKNDLLQRLDAL

NUDT5

171

Q9UKK9
AELAVPIELAQDLLL

CUL7

531

Q14999
QDLLLTLPQRLNDSA

CUL7

541

Q14999
TLPQRLNDSALRDLI

CUL7

546

Q14999
QIEDFEARIALLPLL

NDUFA13

61

Q9P0J0
LLPLLQAETDRRTLQ

NDUFA13

71

Q9P0J0
LRQLVLSLLSLEPAQ

NEK8

231

Q86SG6
PLLEEIDLSDNIIAN

LINGO2

81

Q7L985
QLRLPTDTLQELLDV

GBP4

356

Q96PP9
PALEELLEEAAALNL

GDPD2

336

Q9HCC8
IPLNLTLDNRVADQL

GABRB2

101

P47870
QLRQLSLSLLPELTD

LRRC29

101

Q8WV35
LLDLPCLQFLDLSEN

LRRC46

106

Q96FV0
RELVTEALPLLLDLD

LRRC46

151

Q96FV0
DQALELAPDDNSLLL

LONRF2

221

Q1L5Z9
LAPDDNSLLLLRAEL

LONRF2

226

Q1L5Z9
PRDQLSALIQRLALL

MSLNL

71

Q96KJ4
EDALRLNLLKRSLDP

GATAD2B

6

Q8WXI9
IDANLATDPRFLILL

HPSE

61

Q9Y251
LLLDANQLRELPEQF

LRRC1

41

Q9BTT6
SELPSLENLVLLREL

LRRIQ1

1026

Q96JM4
LIRQPQILLLDEATS

ABCB4

1196

P21439
SLLILVLDANDNAPI

PCDHA10

226

Q9Y5I2
LREQNLRALELEPLE

PRR7

46

Q8TB68
RLLEALQLSLPAEAQ

ARHGAP6

376

O43182
DNASDLALLQLRTPV

PRSS36

406

Q5K4E3
QRLDSDISLEIQAPL

PDP2

236

Q9P2J9
IAELQREPLLVNESL

BOD1L1

2701

Q8NFC6
ALDELENLIVLNPLT

CTNNA3

276

Q9UI47
VENQPRLLLELLELL

EXOC4

331

Q96A65
PDTINSINLDRILLD

CKAP5

1721

Q14008
LPLELGLEQLFQELA

CAPN12

546

Q6ZSI9
PQLLADDDARLLQLE

C1orf43

76

Q9BWL3
IADLPSTQLNRILDL

DOCK8

1316

Q8NF50
EPLDLITSLQNARDI

BRCA2

2476

P51587
ALLQDLPSTAQLLEA

C16orf96

96

A6NNT2
PEENESVLLLRALLD

DNAH3

1621

Q8TD57
DDLPRQEELADNLLI

CEP290

16

O15078
NLPLELENLRSLLES

CHKA

281

P35790
PDRLDLAQSLGLTQL

BARX2

161

Q9UMQ3
TLLSLPVDFNLENIL

BORA

156

Q6PGQ7
NLDAIPLAIARLDNS

CRACD

141

Q6ZU35
SLLLPRAAQILAAEA

COQ10A

51

Q96MF6
ASQPLSRLLDELEVL

IGFLR1

246

Q9H665
LNPLALISRQEALEL

BTD

71

P43251
LDFILSNSPDAQLLR

AGBL2

476

Q5U5Z8
QELLRLTDDSPVDLL

MARF1

1611

Q9Y4F3
LPADAQDLITRLLRQ

MAST3

606

O60307
TLDDRLLNIPINDII

DNAJB13

251

P59910
LLRAPTISDLLNDQD

EDARADD

106

Q8WWZ3
REALLQLPLAVQEEL

KHNYN

176

O15037
PEQLQIAEDNLRALL

SLC44A1

276

Q8WWI5
RFRLQNPDLDSEALL

FAAH

61

O00519
ENVQDLLLLDVAPLS

HSPA1A

386

P0DMV8
ALLLAVSAPLRLQAE

DCBLD1

21

Q8N8Z6
DADNLILNPDTLSLL

COLGALT1

166

Q8NBJ5
SVLNLTELAALRPDL

GTDC1

66

Q4AE62
SIPLLLDLKNEALRD

DNAH10

1331

Q8IVF4
LARFRENLQDLLPIL

SEC14L4

16

Q9UDX3
RDLQLRLLQAPLQAD

SCARA5

106

Q6ZMJ2
LLRLRALAEEPQNSL

DYSF

776

O75923
ALDLLTEEQIGPNRL

NOCT

391

Q9UK39
ILQLARNPDNLEELL

KIFAP3

156

Q92845
RNPDNLEELLLNETA

KIFAP3

161

Q92845
QLTSLPSAIRELENL

LRRC40

116

Q9H9A6
LQRLDLSQNLLDTLP

PIDD1

196

Q9HB75
RDNQLRDLPPELLDA

PIDD1

271

Q9HB75
ALRNSLQELQLDPDP

MROH2A

1631

A6NES4
LGSDQLLQELRDPTL

MAP4K1

776

Q92918
LDSLLLTLLPQLQEA

RSAD1

416

Q9HA92
ILNLEIADRTPQELL

AK9

856

Q5TCS8
LRQLLASLPQTELDE

SERAC1

211

Q96JX3
LILQLLQLEPDEDQV

NR5A1

226

Q13285
LVLDPQQRLAAADVL

STK40

311

Q8N2I9
LQLSDALRDNILPEL

CARS1

611

P49589
LLLDRQQLPAFLELA

FAM83E

186

Q2M2I3
LQNLDRLTFEPLANL

LRTM2

176

Q8N967
DLQPDLDLLTRNVSD

PLCE1

1266

Q9P212
ALSQDALLRISIPLD

SLC22A9

66

Q8IVM8
LLLPESRDQNLPENI

SLC22A23

616

A1A5C7
TLQELLDQEQLLLEP

IQCA1L

16

A6NCM1
LNLNSLDLDEEEVPL

FAM178B

226

Q8IXR5
EDLELLDLSAPFLIQ

POT1

481

Q9NUX5
AAADDLLDLQRNLPE

PSD4

936

Q8NDX1
DLLAPLLVTLDNDQL

SGSM2

841

O43147
REDTPIQLQELLALE

TCAP

106

O15273
QNLARLELPADLLRQ

SAMD11

351

Q96NU1
NLDLDPLELIALANR

RHOBTB1

551

O94844
TDLLLSQNLLRRLPD

SCRIB

246

Q14160
LLDLPIQLMDRLSNE

STRC

1261

Q7RTU9
QAATLLLPDENREVL

STARD8

681

Q92502
RDLQQLDDTTQLPLL

ABCC8

1186

Q09428
RTLDLLNRLENIQSP

AKAP6

1631

Q13023
LSRLALEQERILNPL

PKP3

646

Q9Y446
NLRELLLEDNQLPQI

TLR8

126

Q9NR97
VESLLRPLNSLAALD

ZER1

191

Q7Z7L7
LLLSILNPTRQDESI

ZER1

481

Q7Z7L7
ALLALLPELSVLAQQ

RRBP1

1066

Q9P2E9
LDLLLRLLQAPELET

SARM1

126

Q6SZW1
DLQRLVPLLDSNRLE

SARM1

326

Q6SZW1
PQTLDLVRALQDLEN

RPRD1A

161

Q96P16
ELDILPLQEANAELS

TPR

1301

P12270
AEPADLELLQELNRT

TOM1

246

O60784
SLALDQAQLTPLLRA

TONSL

1051

Q96HA7
LRMDLADLLTQNPEL

UBE2L6

121

O14933
PQLLELLNQLDERRL

HGS

451

O14964
LEDIRNLQDLTPLKL

TRPV2

286

Q9Y5S1
LNLRETNLDSLPLVD

VIM

421

P08670
LEPSESLEENQRNLL

NF1

1326

P21359
LQALEPRQAALLEEA

SPTBN4

1031

Q9H254
LQDMQRLSEELLLPL

RPAP1

821

Q9BWH6
QILPTAQRLLDELLS

ZSWIM8

246

A7E2V4
ELEFSPLLLSINLND

XNDC1N

191

Q6ZNB5
DPDLRFLLDQVQLGL

TSPAN10

196

Q9H1Z9
LLDQDLPLTNSQLSL

SLC30A4

76

O14863
IPLNLSRELLQESAL

TRAP1

396

Q12931
PQENTEEALLLLLIS

TTC7B

321

Q86TV6
LLDRLAQVSPELLLA

XPOT

411

O43592
LLLDLPIQLMDRLSN

STRCP1

1261

A6NGW2
DLTLLLARSQPELIE

TBCD

881

Q9BTW9
NLLLLDRNVDLLTPL

VPS33A

226

Q96AX1
LNSDLLLLQRELIEG

ZNF623

106

O75123
LPANLEILDISRNQL

TLR5

546

O60602
IRPDAFQDLQNLSLL

SLIT1

396

O75093
DENNDAAILILLEPI

TLR2

726

O60603
EPLLSLLQQDRCLAR

VGLL1

166

Q99990
EDLANVSQLPRLESL

ZYG11A

196

Q6WRX3
QPAQALLELLLEEDD

ZFYVE26

166

Q68DK2
RDLSLLILLPEDING

SERPINB10

246

P48595
ALPELEHNLQLLIDL

TFIP11

316

Q9UBB9
ETSAPLRQLLLALLQ

ULK1

246

O75385
IEELARKNLLLEPSL

VPS37A

276

Q8NEZ2
ERLLQQLQTLDSPEL

TSC2

366

P49815
PQAAEDLLLLNRPLT

ULK4

1141

Q96C45
LPLLRSLSLQDNELA

LRRC26

166

Q2I0M4
ASSPRDEDLVQLLLQ

NAALADL1

71

Q9UQQ1