Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionhistone H3K4me/H3K4me2/H3K4me3 demethylase activity

RIOX1 KDM5C

8.09e-056472GO:0034647
GeneOntologyMolecularFunctionhistone H3K4 demethylase activity

RIOX1 KDM5C

1.50e-048472GO:0032453
DomainPentatricopeptide_repeat

LRPPRC GNAS

1.39e-0323452IPR002885
DomainJMJC

RIOX1 KDM5C

2.69e-0332452PS51184
DomainJmjC_dom

RIOX1 KDM5C

2.69e-0332452IPR003347
DomainJmjC

RIOX1 KDM5C

2.86e-0333452SM00558
Pubmed

Identification of imprinted loci by methylation-sensitive representational difference analysis: application to mouse distal chromosome 2.

GNAS CDH15

5.59e-06348210610704
Pubmed

Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

LRPPRC TRAP1 ODAD2 BCS1L RMDN1 COQ7 TMEM70 BAD

3.60e-0592648820877624
Pubmed

Brown adipocyte ATF4 activation improves thermoregulation and systemic metabolism.

LRPPRC GNAS

8.33e-051048234551310
Pubmed

The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.

CKAP5 LAMC1 TRAP1 KDM5C RNF227

9.41e-0533248537433992
Pubmed

Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.

LRPPRC PDF TRAP1 BCS1L RMDN1 COQ7 TMEM70 BAD

1.49e-04113648834800366
Pubmed

Activation of Hedgehog signaling by loss of GNAS causes heterotopic ossification.

GNAS BGLAP

1.68e-041448224076664
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

CKAP5 NCOA7 LAMC1 LRPPRC GNAS KCNA7 BAD

1.69e-0486148736931259
Pubmed

Enpp1 inhibits ectopic joint calcification and maintains articular chondrocytes by repressing hedgehog signaling.

GNAS BGLAP

2.21e-041648230111653
Pubmed

Regulation of ubiquitin-proteasome system-mediated Tip110 protein degradation by USP15.

LRPPRC VARS1

2.21e-041648224984263
Pubmed

Identification of PSD-95 palmitoylating enzymes.

ZDHHC18 GNAS

2.50e-041748215603741
Pubmed

Genome-wide pleiotropy of osteoporosis-related phenotypes: the Framingham Study.

CADM4 TMEM70

2.50e-041748220200953
Pubmed

G-Protein α-Subunit Gsα Is Required for Craniofacial Morphogenesis.

GNAS BGLAP

2.50e-041748226859889
Pubmed

Mice doubly deficient for the Polycomb Group genes Mel18 and Bmi1 reveal synergy and requirement for maintenance but not initiation of Hox gene expression.

PCGF2 BAD

2.81e-041848211290297
Pubmed

Time-sequenced transcriptomes of developing distal mouse limb buds: A comparative tissue layer analysis.

FGF3 NOTUM

4.23e-042248234254395
Pubmed

Runx2 is essential for the transdifferentiation of chondrocytes into osteoblasts.

BGLAP BAD

4.63e-042348233253203
Pubmed

A mitochondrial protein compendium elucidates complex I disease biology.

LRPPRC TRAP1 BCS1L RMDN1 COQ7 TMEM70 BAD

5.51e-04104748718614015
Pubmed

Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia.

CKAP5 RNF31 VARS1

5.89e-0411848321078624
Pubmed

Normal cardiovascular development in mice deficient for 16 genes in 550 kb of the velocardiofacial/DiGeorge syndrome region.

VPREB1 GP1BB

6.89e-042848210963672
Pubmed

Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.

LAMC1 LRPPRC PDF TRAP1 GNAS BCS1L VARS1 TMEM70

7.67e-04145148830550785
Pubmed

Nuclear Gene-Encoded Leigh Syndrome Spectrum Overview

LRPPRC BCS1L

7.92e-043048226425749
Pubmed

Host E3 ligase HUWE1 attenuates the proapoptotic activity of the MERS-CoV accessory protein ORF3 by promoting its ubiquitin-dependent degradation.

CKAP5 LRPPRC TRAP1 GNAS VARS1

8.32e-0453448535032548
Pubmed

Comparative interactome analysis of α-arrestin families in human and Drosophila.

LAMC1 GNAS RNF31 KDM5C

9.17e-0431348438270169
Pubmed

Comparative sequence analysis of 634 kb of the mouse chromosome 16 region of conserved synteny with the human velocardiofacial syndrome region on chromosome 22q11.2.

VPREB1 GP1BB

9.58e-043348210704284
Pubmed

A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.

CKAP5 LRPPRC TRAP1 BCS1L VARS1

1.03e-0356048535241646
Pubmed

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.

CKAP5 PNKP VARS1 TRO KDM5C MAPKAPK3

1.12e-0385748625609649
Pubmed

Chemical Crosslinking Mass Spectrometry Analysis of Protein Conformations and Supercomplexes in Heart Tissue.

LRPPRC TRAP1 BCS1L RMDN1

1.13e-0333148429199018
Pubmed

Sequence-ready physical map of the mouse chromosome 16 region with conserved synteny to the human velocardiofacial syndrome region on 22q11.2.

VPREB1 GP1BB

1.20e-033748210337614
Pubmed

Mitochondrial protein interactome elucidated by chemical cross-linking mass spectrometry.

LRPPRC TRAP1 BCS1L RMDN1

1.28e-0334348428130547
CytobandXp11.22-p11.21

TRO KDM5C

6.41e-064482Xp11.22-p11.21
ToppCell10x_3'_v3-blood_(10x_3'_v3)-myeloid-myeloid_dendritic-plasmacytoid_dendritic_cell|blood_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

HGFAC VPREB1 ODAD2 BGLAP

1.66e-051424847fa6b0f493634d25d68b4365b8c82cd43f5d31db
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal--glomerular_mesenchymal_cell-Renin-positive_Juxtaglomerular_Granular_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

HGFAC RNF31 DUSP2 GP1BB

2.92e-0516448443630a448f4369fa9e4e3eccdf3b9f29cec16c39
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

HGFAC RNF31 DUSP2 GP1BB

2.92e-05164484108fbecb56d69a675d6ce6e826a873ae528f2fd7
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal--glomerular_mesenchymal_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

HGFAC RNF31 DUSP2 GP1BB

2.92e-0516448446208f18325976c89f572f6627aea0582142b92d
ToppCellBAL-Control-Myeloid-MoAM-MoAM5|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ZFTA EFCC1 BCS1L DUSP2

4.87e-0518748459d28f4ee1d463ae20abb8d7e7399b504d80698a
ToppCellControl-Myeloid-MoAM5|Control / Disease group,lineage and cell class (2021.01.30)

ZFTA EFCC1 BCS1L DUSP2

4.87e-051874848769341be67382cea2a590d962f4def7c39de883
ToppCellBAL-Control-Myeloid-MoAM-MoAM5-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ZFTA EFCC1 BCS1L DUSP2

4.87e-0518748425adf648c05c21534b4913254e73d43fc5f64e06
ToppCellBAL-Control-Myeloid-MoAM-MoAM5|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

ZFTA EFCC1 BCS1L DUSP2

4.87e-051874843b0cfa9e5ea5e7d6dda689c328b9b5110b43ee1d
ToppCellBAL-Control-Myeloid-MoAM-MoAM5-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

ZFTA EFCC1 BCS1L DUSP2

4.87e-051874840d589de12108230ced5b60229564f4a181e2f172
ToppCellASK454-Epithelial-Secretory|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq

LAMC1 TRAP1 NOTUM CDH15

5.29e-05191484c63c781e7e93265e591cf494cb4ce8ed797c24fb
ToppCellhuman_hepatoblastoma-Tumor_cells|human_hepatoblastoma / Sample and Cell Type and Tumor Cluster (all cells)

NOTUM SDK1 ABCC6 DNAH14

5.51e-05193484503a979328c68b096680b71359a26f02fafdff35
ToppCelldroplet-Limb_Muscle-MUSCLE-1m-Mesenchymal-nan|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMC1 GNAS CADM4 CDH15

6.08e-051984845e70246a9ce199cb2fb5379912b8ab59456219e4
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW12-Macroglial-Glia_progenitor_cell|GW12 / Sample Type, Dataset, Time_group, and Cell type.

MR1 PPP1R3F DUSP2 MAPKAPK3

6.33e-052004844b937b1d0179d1d0e51931f35720e205d460a07e
DiseaseMitochondrial Diseases

LRPPRC BCS1L TMEM70

6.21e-0549463C0751651
DiseaseMitochondrial disease

LRPPRC BCS1L TMEM70

6.21e-0549463cv:C0751651
Diseasepolycystic kidney disease (biomarker_via_orthology)

GNAS BGLAP

4.00e-0419462DOID:0080322 (biomarker_via_orthology)
Diseasetrait in response to apixaban

RFLNA GNAS TRO

7.75e-04115463OBA_2050328
DiseaseNecrotizing encephalopathy, infantile subacute, of Leigh

LRPPRC BCS1L

1.45e-0336462C2931891
DiseaseLeigh Syndrome due to Mitochondrial Complex V Deficiency

LRPPRC BCS1L

1.45e-0336462C1850600
DiseaseLeigh Syndrome due to Mitochondrial Complex III Deficiency

LRPPRC BCS1L

1.45e-0336462C1850598
DiseaseLeigh Syndrome Due To Mitochondrial Complex II Deficiency

LRPPRC BCS1L

1.45e-0336462C1850597
DiseaseLeigh Syndrome due to Mitochondrial Complex IV Deficiency

LRPPRC BCS1L

1.45e-0336462C1850599
DiseaseSclerocystic Ovaries

GNAS CDH15 GP1BB

1.48e-03144463C1136382
DiseasePolycystic Ovary Syndrome

GNAS CDH15 GP1BB

1.48e-03144463C0032460
DiseaseLEIGH SYNDROME DUE TO MITOCHONDRIAL COMPLEX I DEFICIENCY

LRPPRC BCS1L

1.53e-0337462C1838951
DiseaseHereditary hearing loss and deafness

LRPPRC BCS1L TMEM70

1.54e-03146463cv:C0236038

Protein segments in the cluster

PeptideGeneStartEntry
PKPRALSRSRRYPWR

GNAS

566

P84996
PPNLWAAQRYGRELR

BAD

101

Q92934
WRPFGYPRRRRPLNS

BCS1L

176

Q9Y276
GGDPYRRPARRTQWL

EFCC1

16

Q9HA90
FPPLLWVRLRRDLGY

NWD1

626

Q149M9
RRIRLGQYGFPNPEW

MAPKAPK3

256

Q16644
RLWYVSVNGKGRPRR

FGF3

151

P11487
WNALLRRRARGPPAA

DUSP2

51

Q05923
RAWLAGRPERAPYRD

GP1BB

101

P13224
PIRPHYFWPLLVGRR

LRPPRC

436

P42704
RSYWRHLRRLVLGPP

PDF

46

Q9HBH1
NYVDWINDRIRPPRR

HGFAC

636

Q04756
VKRPRRYLYQWLGAP

BGLAP

46

P02818
PWRRNGPLPLKYRVQ

PCGF2

216

P35227
IRRGIRYWNGVVPER

NOTUM

291

Q6P988
IYRWIRDALRPPLQN

CKAP5

191

Q14008
PERPLPRRAFARQLW

KCNA7

116

Q96RP8
AAAAPRLWRLRPGAR

COQ7

6

Q99807
LVPRSRPAATLRWYR

CADM4

146

Q8NFZ8
AEIRRPRLLWAPKGY

A3GALT2

321

U3KPV4
AAAYPRWNLARARAP

DNAH14

76

Q0VDD8
RAAPALRPRGRLWPV

LAMC1

6

P11047
WRAPYERRSRPRRQW

CROCCP3

256

Q8IVE0
WKRRAQGRAPAPHRY

SDK1

2156

Q7Z5N4
RRPTTLYPWRRAPAL

CDH15

26

P55291
LYPWRRAPALSRVRR

CDH15

31

P55291
LVWRRRPREQNGAIY

MR1

321

Q95460
LLAGPLRPAARRWRN

RTL8A

11

Q9BWD3
PFRYVLDPPARRIWN

VARS1

171

P26640
PAPPSYQRWRVGALR

SUSD2

236

Q9UGT4
LARRLPARVQGYPWR

NCOA7

791

Q8NI08
GLVWRGYRRPLRPKD

ABCC6

221

O95255
RAPPWRQIRGEICYV

ODAD2

236

Q5T2S8
PARRWRRPLPSNVLY

RNF227

161

A6NIN4
IPFRLWVEPRLGRLY

PNKP

501

Q96T60
LEGRKLWRVYRPRVP

RIOX1

351

Q9H6W3
LLSPQRPRYWRGVKF

RNF31

86

Q96EP0
RSGSNYRRIPWGRRP

TRO

421

Q12816
RARWLAPRVRAPGLL

PROM2

46

Q8N271
RLWRLLPFRRGAAPG

RMDN1

6

Q96DB5
WRNYRSQLTLEPRPR

RFLNA

146

Q6ZTI6
WYQQRPGHPPRFLLR

VPREB1

56

P12018
LTWQGPRRRAFLHYP

MTHFSD

336

Q2M296
LPLAQLRRYRPWGGP

PPP1R3F

46

Q6ZSY5
WGRRLRPLLRAPALA

TRAP1

11

Q12931
RLLRRPGRAQIPVYW

TMEM70

61

Q9BUB7
PRRKWEVFPGRNRFY

ZDHHC18

66

Q9NUE0
PPRSREQRRNYQPRW

ZFTA

571

C9JLR9
DRRWARVAQRLNYPP

KDM5C

131

P41229