Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionretinoic acid 4-hydroxylase activity

CYP2C19 CYP2C8 CYP2C9 CYP2C18

1.51e-0714724GO:0008401
GeneOntologyMolecularFunctionlinoleic acid epoxygenase activity

CYP2C19 CYP2C9 CYP2C18

1.79e-074723GO:0071614
GeneOntologyMolecularFunctionarachidonate epoxygenase activity

CYP2C19 CYP2C8 CYP2C9 CYP2C18

1.56e-0624724GO:0008392
GeneOntologyMolecularFunctionoxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor

CYP2C19 CYP2C8 CYP2C9

2.48e-068723GO:0033695
GeneOntologyMolecularFunctioncaffeine oxidase activity

CYP2C19 CYP2C8 CYP2C9

2.48e-068723GO:0034875
GeneOntologyMolecularFunctionarachidonate monooxygenase activity

CYP2C19 CYP2C8 CYP2C9 CYP2C18

2.56e-0627724GO:0008391
GeneOntologyMolecularFunctionestrogen 16-alpha-hydroxylase activity

CYP2C19 CYP2C8 CYP2C9

7.26e-0611723GO:0101020
GeneOntologyMolecularFunctionaromatase activity

CYP2C19 CYP2C8 CYP2C9 CYP2C18

7.48e-0635724GO:0070330
GeneOntologyMolecularFunction(R)-limonene 6-monooxygenase activity

CYP2C19 CYP2C9

1.28e-052722GO:0052741
GeneOntologyMolecularFunctionlimonene monooxygenase activity

CYP2C19 CYP2C9

1.28e-052722GO:0019113
GeneOntologyMolecularFunction(S)-limonene 6-monooxygenase activity

CYP2C19 CYP2C9

1.28e-052722GO:0018675
GeneOntologyMolecularFunction(S)-limonene 7-monooxygenase activity

CYP2C19 CYP2C9

1.28e-052722GO:0018676
GeneOntologyMolecularFunctionoxidoreductase activity, acting on CH or CH2 groups

CYP2C19 CYP2C8 CYP2C9

1.98e-0515723GO:0016725
GeneOntologyMolecularFunctionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

CYP2C19 CYP2C8 CYP2C9 CYP2C18

2.91e-0549724GO:0016712
GeneOntologyMolecularFunctionarachidonate 11,12-epoxygenase activity

CYP2C19 CYP2C9

7.66e-054722GO:0008405
GeneOntologyMolecularFunctionfatty acid omega-1 hydroxylase activity

CYP2C19 CYP2C9

1.27e-045722GO:0120502
GeneOntologyMolecularFunctionlong-chain fatty acid omega-1 hydroxylase activity

CYP2C19 CYP2C9

1.27e-045722GO:0120319
GeneOntologyMolecularFunctionarachidonate 14,15-epoxygenase activity

CYP2C19 CYP2C9

1.27e-045722GO:0008404
GeneOntologyMolecularFunctionsteroid hydroxylase activity

CYP2C19 CYP2C8 CYP2C9

2.48e-0434723GO:0008395
GeneOntologyMolecularFunctionmonooxygenase activity

CYP2C19 CYP2C8 CYP2C9 CYP2C18

7.94e-04115724GO:0004497
GeneOntologyMolecularFunctionFK506 binding

FKBP4 FKBP5

8.27e-0412722GO:0005528
GeneOntologyMolecularFunctionmacrolide binding

FKBP4 FKBP5

1.13e-0314722GO:0005527
GeneOntologyMolecularFunctionguanyl-nucleotide exchange factor activity

DOCK1 VPS9D1 IQSEC2 DOCK10 RAPGEF2

1.48e-03231725GO:0005085
GeneOntologyMolecularFunctionnucleoside-triphosphatase regulator activity

DOCK1 VPS9D1 IQSEC2 DOCK10 SRGAP2 RAPGEF2 ADAP2

2.32e-03507727GO:0060589
GeneOntologyMolecularFunctionGTPase regulator activity

DOCK1 VPS9D1 IQSEC2 DOCK10 SRGAP2 RAPGEF2 ADAP2

2.32e-03507727GO:0030695
GeneOntologyMolecularFunctionheme binding

CYP2C19 CYP2C8 CYP2C9 CYP2C18

2.33e-03154724GO:0020037
GeneOntologyMolecularFunctiontetrapyrrole binding

CYP2C19 CYP2C8 CYP2C9 CYP2C18

2.92e-03164724GO:0046906
GeneOntologyMolecularFunctioniron ion binding

CYP2C19 CYP2C8 CYP2C9 CYP2C18

3.05e-03166724GO:0005506
GeneOntologyMolecularFunctionGTPase activator activity

DOCK1 VPS9D1 SRGAP2 RAPGEF2 ADAP2

3.35e-03279725GO:0005096
GeneOntologyMolecularFunctiontransition metal ion binding

AGBL4 BMI1 UBR2 CYP2C19 CYP2C8 ZCCHC12 CYP2C9 CYP2C18 AICDA PHC1 PPM1B

3.39e-0311897211GO:0046914
GeneOntologyMolecularFunctionATP hydrolysis activity

ATP6V1G3 ABCA12 DYNC2H1 SMC4 KIF28P DHX34

5.13e-03441726GO:0016887
GeneOntologyMolecularFunctionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

CYP2C19 CYP2C8 CYP2C9 CYP2C18

5.31e-03194724GO:0016705
GeneOntologyBiologicalProcessepoxygenase P450 pathway

CYP2C19 CYP2C8 CYP2C9 CYP2C18

9.52e-0722724GO:0019373
GeneOntologyBiologicalProcessomega-hydroxylase P450 pathway

CYP2C19 CYP2C8 CYP2C9

1.44e-0514723GO:0097267
GeneOntologyBiologicalProcesslinoleic acid metabolic process

CYP2C19 CYP2C9 CYP2C18

6.87e-0523723GO:0043651
GeneOntologyBiologicalProcessregulation of synapse assembly

DOCK1 IQSEC2 DOCK10 ELAVL2 SRGAP2 SRGAP2B

7.48e-05202726GO:0051963
GeneOntologyBiologicalProcessarachidonate metabolic process

CYP2C19 CYP2C8 CYP2C9 CYP2C18

9.39e-0568724GO:0019369
GeneOntologyBiologicalProcessregulation of cell junction assembly

DOCK1 IQSEC2 DOCK10 ELAVL2 SRGAP2 SRGAP2B RAPGEF2

1.01e-04309727GO:1901888
GeneOntologyBiologicalProcessmonoterpenoid metabolic process

CYP2C19 CYP2C9

1.79e-046722GO:0016098
DomainCyt_P450_E_grp-I

CYP2C19 CYP2C8 CYP2C9 CYP2C18

2.68e-0545724IPR002401
DomainsrGAP2

SRGAP2 SRGAP2B

4.39e-053722IPR030252
DomainCyt_P450_CS

CYP2C19 CYP2C8 CYP2C9 CYP2C18

5.15e-0553724IPR017972
DomainCYTOCHROME_P450

CYP2C19 CYP2C8 CYP2C9 CYP2C18

6.87e-0557724PS00086
DomainKRAB

ZNF627 ZNF155 ZNF177 ZNF223 ZNF224 ZNF112 ZNF284 ZNF222

6.93e-05358728PS50805
DomainKRAB

ZNF627 ZNF155 ZNF177 ZNF223 ZNF224 ZNF112 ZNF284 ZNF222

6.93e-05358728PF01352
Domain-

CYP2C19 CYP2C8 CYP2C9 CYP2C18

7.36e-05587241.10.630.10
Domainp450

CYP2C19 CYP2C8 CYP2C9 CYP2C18

7.36e-0558724PF00067
DomainCyt_P450

CYP2C19 CYP2C8 CYP2C9 CYP2C18

8.41e-0560724IPR001128
DomainKRAB

ZNF627 ZNF155 ZNF177 ZNF223 ZNF224 ZNF112 ZNF284 ZNF222

8.55e-05369728SM00349
DomainKRAB

ZNF627 ZNF155 ZNF177 ZNF223 ZNF224 ZNF112 ZNF284 ZNF222

8.72e-05370728IPR001909
DomainELAD_HUD_SF

ELAVL2 ELAVL3

8.75e-054722IPR006548
DomainHud_Sxl_RNA

ELAVL2 ELAVL3

6.46e-0410722IPR002343
DomainElongated_TPR_rpt_dom

FKBP4 FKBP5

7.88e-0411722IPR023114
DomainDOCK_C

DOCK1 DOCK10

7.88e-0411722IPR010703
DomainDHR-1_domain

DOCK1 DOCK10

7.88e-0411722IPR027007
DomainDHR_2

DOCK1 DOCK10

7.88e-0411722PS51651
DomainDHR_1

DOCK1 DOCK10

7.88e-0411722PS51650
DomainDOCK-C2

DOCK1 DOCK10

7.88e-0411722PF14429
DomainDHR-2

DOCK1 DOCK10

7.88e-0411722IPR027357
DomainDHR-2

DOCK1 DOCK10

7.88e-0411722PF06920
DomainDOCK

DOCK1 DOCK10

7.88e-0411722IPR026791
DomainZnf_C2H2-like

ZNF627 ZNF155 ZNF177 ZNF223 ZNF224 ZNF112 ANKZF1 DHX34 ZNF284 ZNF222

9.15e-047967210IPR015880
DomainZnF_C2H2

ZNF627 ZNF155 ZNF177 ZNF223 ZNF224 ZNF112 ANKZF1 DHX34 ZNF284 ZNF222

1.03e-038087210SM00355
DomainFKBP_PPIASE

FKBP4 FKBP5

1.70e-0316722PS50059
DomainFKBP_C

FKBP4 FKBP5

1.70e-0316722PF00254
DomainPPIase_FKBP

FKBP4 FKBP5

1.92e-0317722IPR023566
DomainPPIase_FKBP_dom

FKBP4 FKBP5

2.66e-0320722IPR001179
DomainZINC_FINGER_C2H2_2

ZNF627 ZNF155 ZNF177 ZNF223 ZNF224 ZNF112 ANKZF1 ZNF284 ZNF222

2.86e-03775729PS50157
DomainZINC_FINGER_C2H2_1

ZNF627 ZNF155 ZNF177 ZNF223 ZNF224 ZNF112 ANKZF1 ZNF284 ZNF222

2.91e-03777729PS00028
DomainFCH

SRGAP2 SRGAP2B

3.22e-0322722PF00611
DomainFCH

SRGAP2 SRGAP2B

3.22e-0322722SM00055
DomainFCH_dom

SRGAP2 SRGAP2B

3.52e-0323722IPR001060
DomainZnf_C2H2

ZNF627 ZNF155 ZNF177 ZNF223 ZNF224 ZNF112 ANKZF1 ZNF284 ZNF222

3.67e-03805729IPR007087
DomainF_BAR

SRGAP2 SRGAP2B

4.15e-0325722IPR031160
DomainF_BAR

SRGAP2 SRGAP2B

4.15e-0325722PS51741
Domainzf-C2H2

ZNF627 ZNF155 ZNF177 ZNF223 ZNF224 ZNF112 ZNF284 ZNF222

5.10e-03693728PF00096
DomainZnf_C2H2/integrase_DNA-bd

ZNF627 ZNF155 ZNF177 ZNF223 ZNF224 ZNF112 ZNF284 ZNF222

5.14e-03694728IPR013087
PathwayREACTOME_XENOBIOTICS

CYP2C19 CYP2C8 CYP2C9 CYP2C18

2.15e-0623584M5372
PathwayREACTOME_SYNTHESIS_OF_EPOXY_EET_AND_DIHYDROXYEICOSATRIENOIC_ACIDS_DHET

CYP2C19 CYP2C8 CYP2C9

3.65e-068583M27135
PathwayREACTOME_SYNTHESIS_OF_16_20_HYDROXYEICOSATETRAENOIC_ACIDS_HETE

CYP2C19 CYP2C8 CYP2C9

5.46e-069583M27143
PathwayKEGG_LINOLEIC_ACID_METABOLISM

CYP2C19 CYP2C8 CYP2C9 CYP2C18

5.67e-0629584M2920
PathwayREACTOME_CYP2E1_REACTIONS

CYP2C19 CYP2C8 CYP2C9

1.07e-0511583M27130
PathwayWP_OCTADECANOID_FORMATION_FROM_LINOLEIC_ACID

CYP2C19 CYP2C8 CYP2C9

1.42e-0512583M48064
PathwayWP_EICOSANOID_METABOLISM_VIA_CYTOCHROME_P450_MONOOXYGENASES

CYP2C19 CYP2C9 CYP2C18

2.33e-0514583MM15842
PathwayWP_TAMOXIFEN_METABOLISM

CYP2C19 CYP2C8 CYP2C9

8.34e-0521583M39631
PathwayKEGG_ARACHIDONIC_ACID_METABOLISM

CYP2C19 CYP2C8 CYP2C9 CYP2C18

9.27e-0558584M5410
PathwayWP_OXIDATION_BY_CYTOCHROME_P450

CYP2C19 CYP2C8 CYP2C9 CYP2C18

1.20e-0462584M39653
PathwayWP_ESTROGEN_METABOLISM_WP5276

CYP2C19 CYP2C8 CYP2C9

1.26e-0424583M46445
PathwayREACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE

CYP2C19 CYP2C8 CYP2C9 CYP2C18

1.36e-0464584M5650
PathwayKEGG_RETINOL_METABOLISM

CYP2C19 CYP2C8 CYP2C9 CYP2C18

1.36e-0464584M9488
PathwayREACTOME_XENOBIOTICS

CYP2C19 CYP2C8 CYP2C9

1.43e-0425583MM14846
PathwayKEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450

CYP2C19 CYP2C8 CYP2C9 CYP2C18

1.93e-0470584M16794
PathwayKEGG_DRUG_METABOLISM_CYTOCHROME_P450

CYP2C19 CYP2C8 CYP2C9 CYP2C18

2.15e-0472584M9257
PathwayREACTOME_BIOSYNTHESIS_OF_MARESIN_LIKE_SPMS

CYP2C8 CYP2C9

2.47e-046582M27909
PathwayWP_ARACHIDONATE_EPOXYGENASE_EPOXIDE_HYDROLASE

CYP2C8 CYP2C9

3.45e-047582M39515
PathwayREACTOME_SYNTHESIS_OF_EPOXY_EET_AND_DIHYDROXYEICOSATRIENOIC_ACIDS_DHET

CYP2C19 CYP2C8

3.45e-047582MM14856
PathwayREACTOME_BIOSYNTHESIS_OF_MARESINS

CYP2C8 CYP2C9

4.58e-048582M27891
PathwayWP_EICOSANOID_METABOLISM_VIA_CYTOCHROME_P450_MONOOXYGENASES_PATHWAY

CYP2C8 CYP2C18

5.88e-049582M39819
PathwayREACTOME_ASPIRIN_ADME

CYP2C19 CYP2C8 CYP2C9

7.77e-0444583M45014
PathwayREACTOME_PHASE_I_FUNCTIONALIZATION_OF_COMPOUNDS

CYP2C19 CYP2C8 CYP2C9 CYP2C18

8.74e-04104584M738
PathwayREACTOME_SYNTHESIS_OF_16_20_HYDROXYEICOSATETRAENOIC_ACIDS_HETE

CYP2C19 CYP2C8

8.93e-0411582MM14863
PathwayWP_METAPATHWAY_BIOTRANSFORMATION_PHASE_I_AND_II

CYP2C19 CYP2C8 CYP2C9 CYP2C18 HS6ST2

9.16e-04183585M39588
PathwayREACTOME_CYP2E1_REACTIONS

CYP2C19 CYP2C8

1.07e-0312582MM14847
PathwayREACTOME_BIOSYNTHESIS_OF_MARESINS

CYP2C19 CYP2C8

1.07e-0312582MM15616
PathwayBIOCARTA_PRC2_PATHWAY

BMI1 PHC1

1.47e-0314582M22025
PathwayREACTOME_ARACHIDONIC_ACID_METABOLISM

CYP2C19 CYP2C8 CYP2C9

1.82e-0359583M27140
PathwayREACTOME_SUMOYLATION_OF_DNA_METHYLATION_PROTEINS

BMI1 PHC1

1.92e-0316582M27403
PathwayREACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE

CYP2C19 CYP2C8 CYP2C9

2.52e-0366583MM14839
PathwayREACTOME_BIOSYNTHESIS_OF_SPECIALIZED_PRORESOLVING_MEDIATORS_SPMS

CYP2C8 CYP2C9

2.72e-0319582M27889
Pubmed

Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters.

ZNF155 ZNF223 ZNF224 ZNF112 ZNF284 ZNF222

2.85e-122074612743021
Pubmed

Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450IIC subfamily.

CYP2C19 CYP2C8 CYP2C9 CYP2C18

1.89e-1147442009263
Pubmed

Genetic variation in the CYP2C monooxygenase enzyme subfamily shows no association with longevity in a German population.

CYP2C19 CYP2C8 CYP2C9 CYP2C18

1.89e-11474421798861
Pubmed

Biochemistry and molecular biology of the human CYP2C subfamily.

CYP2C19 CYP2C8 CYP2C9 CYP2C18

1.89e-1147447704034
Pubmed

Genetic variants associated with warfarin dose in African-American individuals: a genome-wide association study.

CYP2C19 CYP2C8 CYP2C9 CYP2C18

1.89e-11474423755828
Pubmed

Association of cytochrome P450 2C19 genotype with the antiplatelet effect and clinical efficacy of clopidogrel therapy.

CYP2C19 CYP2C8 CYP2C9 CYP2C18

1.89e-11474419706858
Pubmed

Polymorphisms of CYP2C8, CYP2C9 and CYP2C19 and risk of coronary heart disease in Russian population.

CYP2C19 CYP2C8 CYP2C9

9.25e-09374328687336
Pubmed

The human CYP2C locus: a prototype for intergenic and exon repetition splicing events.

CYP2C8 CYP2C9 CYP2C18

9.25e-09374310704292
Pubmed

A 2.4-megabase physical map spanning the CYP2C gene cluster on chromosome 10q24.

CYP2C19 CYP2C8 CYP2C9

9.25e-0937438530044
Pubmed

Global pharmacogenomics: Impact of population diversity on the distribution of polymorphisms in the CYP2C cluster among Brazilians.

CYP2C19 CYP2C8 CYP2C9

9.25e-09374321173785
Pubmed

Cloning, expression, and characterization of three new mouse cytochrome p450 enzymes and partial characterization of their fatty acid oxidation activities.

CYP2C19 CYP2C9 CYP2C18

9.25e-09374315102943
Pubmed

CYP2C8, CYP2C9, and CYP2C19 Characterization Using Next-Generation Sequencing and Haplotype Analysis: A GeT-RM Collaborative Project.

CYP2C19 CYP2C8 CYP2C9

9.25e-09374335134542
Pubmed

Genetic polymorphisms of CYP2C8, CYP2C9 and CYP2C19 in Ecuadorian Mestizo and Spaniard populations: a comparative study.

CYP2C19 CYP2C8 CYP2C9

9.25e-09374324430292
Pubmed

Distribution of CYP2C polymorphisms in an Amerindian population of Brazil.

CYP2C19 CYP2C8 CYP2C9

9.25e-09374321977947
Pubmed

Linkage disequilibrium between the CYP2C19*17 allele and wildtype CYP2C8 and CYP2C9 alleles: identification of CYP2C haplotypes in healthy Nordic populations.

CYP2C19 CYP2C8 CYP2C9

9.25e-09374320665013
Pubmed

Genetic Polymorphisms and in Vitro Functional Characterization of CYP2C8, CYP2C9, and CYP2C19 Allelic Variants.

CYP2C19 CYP2C8 CYP2C9

9.25e-09374327803446
Pubmed

Characterisation of CYP2C8, CYP2C9 and CYP2C19 polymorphisms in a Ghanaian population.

CYP2C19 CYP2C8 CYP2C9

9.25e-09374319954515
Pubmed

Cloning and expression of complementary DNAs for multiple members of the human cytochrome PH50IIC subfamily.

CYP2C19 CYP2C9 CYP2C18

9.25e-0937438095407
Pubmed

Structural characterization of human cytochrome P450 2C19: active site differences between P450s 2C8, 2C9, and 2C19.

CYP2C19 CYP2C8 CYP2C9

9.25e-09374323118231
Pubmed

Novel DNA sequence variations of cytochrome P450 genes in the Han Chinese population.

CYP2C19 CYP2C8 CYP2C9 CYP2C18

1.86e-081474419290787
Pubmed

Association of warfarin dose with genes involved in its action and metabolism.

CYP2C19 CYP2C8 CYP2C9 CYP2C18

3.37e-081674417048007
Pubmed

Polymorphism of CYP2D6, CYP2C19, CYP2C9 and CYP2C8 in the Faroese population.

CYP2C19 CYP2C8 CYP2C9

3.69e-08474316025294
Pubmed

Effect of Chronic Kidney Disease on Nonrenal Elimination Pathways: A Systematic Assessment of CYP1A2, CYP2C8, CYP2C9, CYP2C19, and OATP.

CYP2C19 CYP2C8 CYP2C9

3.69e-08474328990182
Pubmed

Molecular genetics of the human cytochrome P450 monooxygenase superfamily.

CYP2C19 CYP2C8 CYP2C9 CYP2C18

8.91e-08207449890157
Pubmed

Prevalence of CYP450 gene variations in patients with type 2 diabetes.

CYP2C19 CYP2C8 CYP2C9

9.22e-08574320857895
Pubmed

Non-response to antiepileptic pharmacotherapy is associated with the ABCC2 -24C>T polymorphism in young and adult patients with epilepsy.

CYP2C19 CYP2C8 CYP2C9

9.22e-08574319415824
Pubmed

A genome-wide association study of acenocoumarol maintenance dosage.

CYP2C19 CYP2C9 CYP2C18

1.84e-07674319578179
Pubmed

Genetic polymorphism of cytochrome P450s and P-glycoprotein in the Finnish population.

CYP2C19 CYP2C8 CYP2C9

1.84e-07674317635176
Pubmed

Evaluation of candidate genes for cholinesterase activity in farmworkers exposed to organophosphorus pesticides: association of single nucleotide polymorphisms in BCHE.

CYP2C19 CYP2C8 CYP2C9 CYP2C18

4.96e-073074420529763
Pubmed

Hepatic cytochrome P450 enzyme alterations in humans with progressive stages of nonalcoholic fatty liver disease.

CYP2C19 CYP2C8 CYP2C9

1.10e-061074319651758
Pubmed

Genetic profile of patients with epilepsy on first-line antiepileptic drugs and potential directions for personalized treatment.

CYP2C19 CYP2C8 CYP2C9

1.10e-061074320602612
Pubmed

Quantitative contribution of CYP2D6 and CYP3A to oxycodone metabolism in human liver and intestinal microsomes.

CYP2C19 CYP2C8 CYP2C9

1.51e-061174315039299
Pubmed

Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population.

CYP2C19 CYP2C8 CYP2C9

1.51e-061174315469410
Pubmed

CYP2B6, CYP3A4, and CYP2C19 are responsible for the in vitro N-demethylation of meperidine in human liver microsomes.

CYP2C19 CYP2C8 CYP2C18

2.01e-061274315319333
Pubmed

Targeting RICTOR Sensitizes SMAD4-Negative Colon Cancer to Irinotecan.

DOCK1 MALT1 USP24 GBE1 SRGAP2 UQCRB

2.69e-0618374631932471
Pubmed

Toward personalized medicine in renal transplantation.

CYP2C19 CYP2C8 CYP2C9

3.31e-061474320970553
Pubmed

Molecular cloning, expression and characterization of an endogenous human cytochrome P450 arachidonic acid epoxygenase isoform.

CYP2C8 CYP2C9

4.47e-0627427574697
Pubmed

CYP2C9, but not CYP2C19, polymorphisms affect the pharmacokinetics and pharmacodynamics of glyburide in Chinese subjects.

CYP2C19 CYP2C9

4.47e-06274216198656
Pubmed

Individuals with CYP2C8 and CYP2C9 reduced metabolism haplotypes self-adjusted ibuprofen dose in the Coriell Personalized Medicine Collaborative.

CYP2C8 CYP2C9

4.47e-06274230562214
Pubmed

Effect of gender and CYP2C9 and CYP2C8 polymorphisms on the pharmacokinetics of ibuprofen enantiomers.

CYP2C8 CYP2C9

4.47e-06274226122864
Pubmed

A new anti-depressive strategy for the elderly: ablation of FKBP5/FKBP51.

FKBP4 FKBP5

4.47e-06274221935478
Pubmed

Role of xenobiotic metabolism enzyme gene polymorphism in the formation of chemotherapy resistance in patients with chronic lymphoproliferative diseases.

CYP2C8 CYP2C9

4.47e-06274224288737
Pubmed

[Association between genetic polymorphisms of CYP2C19 and CYP2C9 and phenytoin serum concentration].

CYP2C19 CYP2C9

4.47e-06274215569425
Pubmed

Multi-ethnic distribution of clinically relevant CYP2C genotypes and haplotypes.

CYP2C19 CYP2C8

4.47e-06274222491019
Pubmed

FKBP5/FKBP51 enhances autophagy to synergize with antidepressant action.

BECN1 FKBP5

4.47e-06274225714272
Pubmed

Subcellular rearrangement of hsp90-binding immunophilins accompanies neuronal differentiation and neurite outgrowth.

FKBP4 FKBP5

4.47e-06274220796173
Pubmed

Linkage between the CYP2C8 and CYP2C9 genetic polymorphisms.

CYP2C8 CYP2C9

4.47e-06274212435384
Pubmed

Important amino acid residues that confer CYP2C19 selective activity to CYP2C9.

CYP2C19 CYP2C9

4.47e-06274218511451
Pubmed

Distribution of CYP2C8 and CYP2C9 amino acid substitution alleles in South Indian diabetes patients: A genotypic and computational protein phenotype study.

CYP2C8 CYP2C9

4.47e-06274228686288
Pubmed

Influence of CYP2C8 and CYP2C9 polymorphisms on pharmacokinetic and pharmacodynamic parameters of racemic and enantiomeric forms of ibuprofen in healthy volunteers.

CYP2C8 CYP2C9

4.47e-06274218694831
Pubmed

Are cytochrome P450 CYP2C8 and CYP2C9 polymorphisms associated with ibuprofen response in very preterm infants?

CYP2C8 CYP2C9

4.47e-06274220808793
Pubmed

Developmental expression of human hepatic CYP2C9 and CYP2C19.

CYP2C19 CYP2C9

4.47e-06274214634042
Pubmed

Generation and characterization of novel cytochrome P450 Cyp2c gene cluster knockout and CYP2C9 humanized mouse lines.

CYP2C9 CYP2C18

4.47e-06274222918969
Pubmed

Differential conformational dynamics in the closely homologous FK506-binding domains of FKBP51 and FKBP52.

FKBP4 FKBP5

4.47e-06274224749623
Pubmed

The effect of the cytochrome P450 CYP2C8 polymorphism on the disposition of (R)-ibuprofen enantiomer in healthy subjects.

CYP2C8 CYP2C9

4.47e-06274215606441
Pubmed

An association between the rs1799853 and rs1057910 polymorphisms of CYP2C9, the rs4244285 polymorphism of CYP2C19 and the prevalence rates of drug-resistant epilepsy in children.

CYP2C19 CYP2C9

4.47e-06274232567426
Pubmed

CYP2C40, a unique arachidonic acid 16-hydroxylase, is the major CYP2C in murine intestinal tract.

CYP2C19 CYP2C9

4.47e-06274210908295
Pubmed

Role of CYP2C9 and CYP2C19 polymorphisms in patients with atherosclerosis.

CYP2C19 CYP2C9

4.47e-06274217868191
Pubmed

Impact of CYP2C19 and CYP2C9 gene polymorphisms on sodium valproate plasma concentration in patients with epilepsy.

CYP2C19 CYP2C9

4.47e-06274232868386
Pubmed

CYP2C9 and CYP2C19 Allele and Haplotype Distributions in Four Mestizo Populations from Western Mexico: An Interethnic Comparative Study.

CYP2C19 CYP2C9

4.47e-06274227617498
Pubmed

Oxygenation mechanism in conversion of aldehyde to carboxylic acid catalyzed by a cytochrome P-450 isozyme.

CYP2C19 CYP2C9

4.47e-0627421847130
Pubmed

Influence of the CYP2C9 AND CYP2C19 polymorphisms on phenytoin hydroxylation in healthy individuals from south India.

CYP2C19 CYP2C9

4.47e-06274216873909
Pubmed

The contribution of CYP2C gene subfamily involved in epoxygenase pathway of arachidonic acids metabolism to hypertension susceptibility in Russian population.

CYP2C19 CYP2C8

4.47e-06274228513222
Pubmed

Cytochromes P450 catalyze oxidation of alpha,beta-unsaturated aldehydes.

CYP2C19 CYP2C9

4.47e-06274217599801
Pubmed

Few alterations in clinical pathology and histopathology observed in a CYP2C18&19 humanized mice model.

CYP2C19 CYP2C18

4.47e-06274219038035
Pubmed

Evidence that CYP2C19 is the major (S)-mephenytoin 4'-hydroxylase in humans.

CYP2C19 CYP2C18

4.47e-0627428110777
Pubmed

Comparison of the in vitro mutagenicity and metabolism of dimethylnitrosamine and benzo[a]pyrene in tissues from inbred mice treated with phenobarbital, 3-methylcholanthrene or polychlorinated biphenyls.

CYP2C19 CYP2C9

4.47e-062742106274
Pubmed

Dosage recommendation of phenytoin for patients with epilepsy with different CYP2C9/CYP2C19 polymorphisms.

CYP2C19 CYP2C9

4.47e-06274215385837
Pubmed

[Effect of original and generic clopidogrel on prognosis in relation to different gene polymorphisms].

CYP2C19 CYP2C9

4.47e-06274225518510
Pubmed

Gene structure and upstream regulatory regions of human CYP2C9 and CYP2C18.

CYP2C9 CYP2C18

4.47e-0627428333835
Pubmed

Effect of genetic polymorphisms in cytochrome p450 (CYP) 2C9 and CYP2C8 on the pharmacokinetics of oral antidiabetic drugs: clinical relevance.

CYP2C8 CYP2C9

4.47e-06274216372821
Pubmed

Genetic polymorphism of CYP2C9 and CYP2C19 in a Bolivian population: an investigative and comparative study.

CYP2C19 CYP2C9

4.47e-06274215776277
Pubmed

Chlorpropamide 2-hydroxylation is catalysed by CYP2C9 and CYP2C19 in vitro: chlorpropamide disposition is influenced by CYP2C9, but not by CYP2C19 genetic polymorphism.

CYP2C19 CYP2C9

4.47e-06274215842554
Pubmed

Effect of cytochrome P450 2C19 and 2C9 amino acid residues 72 and 241 on metabolism of tricyclic antidepressant drugs.

CYP2C19 CYP2C9

4.47e-06274224492587
Pubmed

Rapid identification of the hepatic cytochrome P450 2C19 activity using a novel and noninvasive [13C]pantoprazole breath test.

CYP2C19 CYP2C9

4.47e-06274219136640
Pubmed

Mouse Cyp2c expression and zonation structure in the liver begins in the early neonatal stage.

CYP2C19 CYP2C9

4.47e-06274235748067
Pubmed

Phase I pharmacokinetic and pharmacogenomic study of E7070 administered once every 21 days.

CYP2C19 CYP2C9

4.47e-06274216232205
Pubmed

Linkage disequilibrium between the CYP2C19*17 and CYP2C8*2 alleles in populations of African descent.

CYP2C19 CYP2C8

4.47e-06274220890775
Pubmed

The clinically relevant CYP2C8*3 and CYP2C9*2 haplotype is inherited from Neandertals.

CYP2C8 CYP2C9

4.47e-06274235780191
Pubmed

Time serial transcriptome reveals Cyp2c29 as a key gene in hepatocellular carcinoma development.

CYP2C19 CYP2C9

4.47e-06274232587777
Pubmed

Genetic polymorphisms of cytochrome P450 enzymes 2C9 and 2C19 in a healthy Mongolian population in China.

CYP2C19 CYP2C9

4.47e-06274220845310
Pubmed

Genetic polymorphisms of cytochrome P450 enzymes 2C9 and 2C19 in a healthy Iranian population.

CYP2C19 CYP2C9

4.47e-06274217201743
Pubmed

CYP2C9 (*2&*3) and CYP2C19 (*2&*3) polymorphisms among children with nonlesional epilepsy: a single-center study.

CYP2C19 CYP2C9

4.47e-06274232683556
Pubmed

Relationship between CYP2C8 genotypes and diclofenac 5-hydroxylation in healthy Spanish volunteers.

CYP2C8 CYP2C9

4.47e-06274218548238
Pubmed

Interaction of CYP2C8 and CYP2C9 genotypes modifies the risk for nonsteroidal anti-inflammatory drugs-related acute gastrointestinal bleeding.

CYP2C8 CYP2C9

4.47e-06274218216720
Pubmed

Evaluation of phenytoin dosage regimens based on genotyping of CYP2C subfamily in routinely treated Japanese patients.

CYP2C19 CYP2C9

4.47e-06274215855721
Pubmed

Cloning and expression of murine CYP2Cs and their ability to metabolize arachidonic acid.

CYP2C19 CYP2C9

4.47e-0627429721182
Pubmed

Genetic variance in CYP2C8 and increased risk of myocardial infarction.

CYP2C8 CYP2C9

4.47e-06274220436375
Pubmed

The effects of CYP2C9 and CYP2C19 genetic polymorphisms on the pharmacokinetics and pharmacodynamics of glipizide in Chinese subjects.

CYP2C19 CYP2C9

4.47e-06274219847408
Pubmed

CYP2C9 and CYP2C19 polymorphic forms are related to increased indisulam exposure and higher risk of severe hematologic toxicity.

CYP2C19 CYP2C9

4.47e-06274217504998
Pubmed

Cytochrome P450 2C epoxygenases mediate photochemical stress-induced death of photoreceptors.

CYP2C19 CYP2C9

4.47e-06274224519941
Pubmed

Mouse liver CYP2C39 is a novel retinoic acid 4-hydroxylase. Its down-regulation offers a molecular basis for liver retinoid accumulation and fibrosis in aryl hydrocarbon receptor-null mice.

CYP2C19 CYP2C9

4.47e-06274214623888
Pubmed

Fluorescence in situ hybridization analysis of chromosomal localization of three human cytochrome P450 2C genes (CYP2C8, 2C9, and 2C10) at 10q24.1.

CYP2C8 CYP2C9

4.47e-0627427841444
Pubmed

Cytochrome P450 polymorphisms in patients with Behcet's disease.

CYP2C19 CYP2C9

4.47e-06274217269966
Pubmed

Allelic variants of cytochromes P450 2C modify the risk for acute myocardial infarction.

CYP2C8 CYP2C9

4.47e-06274214646690
Pubmed

Changes at the CYP2C locus and disruption of CYP2C8/9 linkage disequilibrium in patients with essential tremor.

CYP2C8 CYP2C9

4.47e-06274217627038
Pubmed

Molecular chaperone activity and biological regulatory actions of the TPR-domain immunophilins FKBP51 and FKBP52.

FKBP4 FKBP5

4.47e-06274224694367
Pubmed

Correlation of major depressive disorder symptoms with FKBP5 but not FKBP4 expression in human immunodeficiency virus-infected individuals.

FKBP4 FKBP5

4.47e-06274220726698
Pubmed

Metabolism of (+)- and (-)-limonenes to respective carveols and perillyl alcohols by CYP2C9 and CYP2C19 in human liver microsomes.

CYP2C19 CYP2C9

4.47e-06274211950794
Pubmed

FKBP51 and FKBP52 regulate androgen receptor dimerization and proliferation in prostate cancer cells.

FKBP4 FKBP5

4.47e-06274234057812
InteractionCYP2C19 interactions

CYP2C19 CYP2C9 CYP2C18

4.54e-075733int:CYP2C19
InteractionCYP2C18 interactions

CYP2C19 CYP2C8 CYP2C9 CYP2C18

2.61e-0627734int:CYP2C18
InteractionZNF284 interactions

ZNF223 ZNF112 ZNF284

1.61e-0514733int:ZNF284
Cytoband10q24

CYP2C19 CYP2C9 CYP2C18

2.54e-053574310q24
Cytoband19q13.2

ZNF223 ZNF224 ZNF112 ZNF222

1.49e-0416474419q13.2
CytobandEnsembl 112 genes in cytogenetic band chr10q23

CYP2C19 CYP2C8 CYP2C9 CYP2C18

2.88e-04195744chr10q23
CytobandEnsembl 112 genes in cytogenetic band chr19q13

ZNF155 USP29 ZNF223 ZNF224 ZNF112 DHX34 ZNF284 ZNF222

6.68e-041192748chr19q13
GeneFamilyCytochrome P450 family 2

CYP2C19 CYP2C8 CYP2C9 CYP2C18

5.31e-06356041001
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF627 ZNF155 ZNF177 ZNF223 ZNF224 ZNF112 ANKZF1 ZNF284 ZNF222

5.62e-0471860928
GeneFamilyFKBP prolyl isomerases

FKBP4 FKBP5

1.60e-0318602910
GeneFamilyRho GTPase activating proteins|F-BAR domain containing

SRGAP2 SRGAP2B

2.62e-03236021288
ToppCell3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

AGBL4 DYNC2H1 CFAP43 BBS5 CCDC180 MYCBPAP

9.44e-0719774674a2c6cb8fcfe53dd9a2b36492a16c58f38e51c9
ToppCelllung-Ciliated_Epithelia|lung / shred on tissue and cell subclass

SEC14L3 DYNC2H1 CFAP43 CCDC180 MYCBPAP

8.69e-0616774526cf1cfa58ee74794449a87eb19cd896e1ec8892
ToppCellE18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_G2M|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

HS6ST2 ASPM SMC4 CKAP2 RAPGEF2

1.09e-051757453e56695a9db97cb1d3503425c48eb79bbf99213e
ToppCell3'-GW_trimst-1-LargeIntestine-Neuronal-neuron_precursor-cycling_neuroblast|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ASPM SMC4 ELAVL2 ELAVL3 CKAP2

1.58e-05189745815afad947ed77a8b03724bf78014799fed34f54
ToppCellPND14-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SEC14L3 HS6ST2 CFAP43 CCDC180 MYCBPAP

1.62e-0519074535248a8be476ea8d06d67c3d98a25be1f7c150b7
ToppCellPND14-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated-Ciliated_mature|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SEC14L3 HS6ST2 CFAP43 CCDC180 MYCBPAP

1.62e-051907455f5206f9e725070d865f4c891ff08bb750e58582
ToppCellPND14-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SEC14L3 HS6ST2 CFAP43 CCDC180 MYCBPAP

1.62e-05190745088e3f39a1e5e11354d6e7458e8e6a39f14936b3
ToppCell10x_3'_v2v3-Neoplastic-Stem-like-NPC-like-NPC-like_Prolif-D|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

ASPM SMC4 ELAVL2 ELAVL3 CKAP2

1.70e-05192745f518839ecd9377537a414e8798766f7d91eafeac
ToppCellfacs-Brain_Myeloid-Hippocampus-3m-Myeloid|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

USP24 DOCK10 SRGAP2 FKBP5 ADAP2

1.75e-0519374506b65110db974f4ef90d3511ff34428976a52c9c
ToppCellfacs-Brain_Myeloid-Hippocampus-3m-Myeloid-microglial_cell|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

USP24 DOCK10 SRGAP2 FKBP5 ADAP2

1.75e-051937459c16032bc03df8760ae199e8f19fdafa4c3f1827
ToppCellfacs-Brain_Myeloid-Hippocampus-3m|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

USP24 DOCK10 SRGAP2 FKBP5 ADAP2

1.75e-05193745a4f91bca5eaa985982d33a528f7566ffde154d47
ToppCellfacs-Brain_Myeloid-Hippocampus-3m-Myeloid-nan|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

USP24 DOCK10 SRGAP2 FKBP5 ADAP2

1.75e-05193745b39d7feaac4ff8f7409cd3d15e8f3c6391367275
ToppCellParenchymal-10x3prime_v2-Immune_Myeloid-Dendritic_cell-DC_activated|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

BYSL DOCK10 NEB DHX34 ADAP2

2.02e-051997453b2bd3caf4d189a1726a737b0121860b265eec04
ToppCellParenchymal-10x3prime_v2-Immune_Myeloid-Macrophage_other-Macro_AW_CX3CR1|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

MALT1 TNRC18 DOCK10 ANKZF1 ADAP2

2.02e-05199745bbb4798d6a24e756fea744a151ba67c1bafbac9a
ToppCellTCGA-Bile_Duct|World / Sample_Type by Project: Shred V9

CYP2C19 CYP2C8 CYP2C9 CYP2C18

8.73e-05140744ca8a0ccbc2f501b759864fe9bb06dc8b44b6b31f
ToppCellLPS-antiTNF-Unknown-Endothelial-Monocytes-Macrophages|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

UBR2 KCTD9 BECN1 ZNF222

9.22e-05142744b66f9602dba30d1d4fbcc49ceb112eb5bd916ba1
ToppCellPND07-Immune-Immune_Myeloid-Monocytic-Macrophage-iMON-iMON_G2M|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ASPM SMC4 CDH23 CKAP2

1.03e-0414674445d7cb73776e60d22f335a651845e21e16948fcc
ToppCellfacs-Brain_Non-Myeloid-Hippocampus_-18m-Epithelial-neuronal_stem_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KRT12 USP29 CKAP2 MYCBPAP

1.14e-0415074447ea08d7609e1d2382bf56ef9e5c767e3597cf93
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

AGBL4 ABCA12 DYNC2H1 DHX34

1.23e-041537449b6675ace8a83c8d446b722301d0ec4e6840f3fc
ToppCell3'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ASPM ELAVL2 CKAP2 NEB

1.50e-041617442165897924c790fec43502283f1df221c56c1e9f
ToppCellPND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_G2M|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

AGBL4 ASPM CKAP2 FREM1

1.80e-04169744563c267edaade0e5df192ad953801ef9768d4270
ToppCell5'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

AGBL4 DYNC2H1 CFAP43 MYCBPAP

1.80e-04169744fba841664939c771881ba97f14ef1df6635c04ff
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_G2M|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ASPM SMC4 CKAP2 ZNF112

1.84e-0417074421bfe070e63722672176052b386167ea4c3dc4e5
ToppCellE18.5-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-Sox9_Epi-Sox9_Epi_G2M|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

USP29 ASPM SMC4 CKAP2

1.88e-04171744621f9da0bfa09c86fc89fd26919403e94cd56d2b
ToppCellThalamus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Slc17a6-Rora-Excitatory_Neuron.Slc17a6.Rora.Cbln2_(Neuron.Slc17a6.Rora.Cbln2)|Thalamus / BrainAtlas - Mouse McCarroll V32

KRT12 ABCA12 NEB

1.90e-04677435202166895fd109ad0d7584fc35c74814a59ce2b
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ATP6V1G3 DOCK10 ELAVL2 FREM1

2.06e-0417574498947a226b5a2ac7091ff9d34243ea7736add973
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ATP6V1G3 DOCK10 ELAVL2 FREM1

2.06e-0417574477c16e615c0fb9c83f29d7e0a547be72635fac81
ToppCellfacs-Trachea-nan-18m-Epithelial-ciliated_columnar_cell_of_tracheobronchial_tree|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SEC14L3 CFAP43 CCDC180 MYCBPAP

2.10e-04176744ed788a5969edfd1199828ca5b0dd34e7f29c4d30
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SEC14L3 DYNC2H1 CFAP43 MYCBPAP

2.10e-04176744dee780cfa85234a7cd7bf440b66b84cec959893e
ToppCellfacs-Trachea-3m-Epithelial-airway_epithelial-tracheobronchial_ciliated_cell-ciliated_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SEC14L3 KRT12 CCDC180 MYCBPAP

2.15e-041777443cfde67b93f3986312f5e74e42504214d966e7dc
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Degenerative_Distal_Convoluted_Tubule_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

HS6ST2 USP24 UQCRB FREM1

2.15e-04177744dc846d0feb94d4c289553cc3ac9dac81d10409cb
ToppCellfacs-Trachea-3m-Epithelial-airway_epithelial-tracheobronchial_ciliated_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SEC14L3 KRT12 CCDC180 MYCBPAP

2.15e-0417774412a52a12a87a31e501ced611f46a90d172ca7e35
ToppCellDividing_Macrophages-Donor_05|World / lung cells shred on cell class, cell subclass, sample id

XKR3 AICDA ASPM CKAP2

2.20e-041787446557688c6790a5bcc3b9aea5b8789cf9506b3c54
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ATP6V1G3 DOCK10 ELAVL2 FREM1

2.24e-04179744e6ae070b4c52ba08167c7d64ea4cfbac0454c1bf
ToppCellfacs-Trachea-18m-Epithelial-airway_epithelial-tracheobronchial_ciliated_cell-ciliated_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SEC14L3 CFAP43 CCDC180 MYCBPAP

2.24e-04179744d4efbc34f52136039b96451fd0b0a0ad164197c6
ToppCellfacs-Trachea-18m-Epithelial-airway_epithelial-tracheobronchial_ciliated_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SEC14L3 CFAP43 CCDC180 MYCBPAP

2.24e-041797448a66d197a2f55d763ff7ef0bec89ee96f59c3937
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

AGBL4 DYNC2H1 USP24 FREM1

2.24e-04179744666072c0e8448dbaec1683d18368ec2502453f90
ToppCell3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DYNC2H1 CFAP43 BBS5 CCDC180

2.29e-0418074492fb01b91261b3103454924cde56add337b41844
ToppCellsevere-CD8+_T_naive|severe / disease stage, cell group and cell class

CLCN6 GBE1 ANKZF1 MYCBPAP

2.29e-0418074494fe530367b170777f4051a4034cff06d80dbb83
ToppCellHealthy_Control-Lymphoid-T-|Healthy_Control / Condition, Lineage, Cell class and cell subclass

CYP2C8 ASPM SMC4 CKAP2

2.34e-04181744ac1ee313910c05b1b3cb497bae14565464919c21
ToppCellsevere-CD8+_T_naive|World / disease stage, cell group and cell class

CLCN6 GBE1 ANKZF1 MYCBPAP

2.34e-0418174469eeeb7f326e230b07495d557f708fbe3312ac0a
ToppCell356C-Lymphocytic-CD4_T-cell-Proliferating_T_cell|356C / Donor, Lineage, Cell class and subclass (all cells)

ASPM SMC4 CKAP2 FREM1

2.34e-04181744be4f35c9eb5b3083acb2264128f095fac1f3da45
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_PAX6|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KRT12 DOCK10 CDH23 FREM1

2.39e-0418274486a2330ada7637144a67afbf9f3a902901ab1130
ToppCellwk_15-18-Epithelial-Proximal_epithelial-Deuterosomal|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

AGBL4 CFAP43 CCDC180 MYCBPAP

2.39e-04182744000eca5baa6eb2335a1e6d76a13fff5382b0e150
ToppCellCOVID-19-kidney-CD-IC-A|kidney / Disease (COVID-19 only), tissue and cell type

ATP6V1G3 DOCK10 ELAVL2 FREM1

2.44e-041837445c7597a5b2bf6a481ca2c7e68560179214150fa0
ToppCellPND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC-VSMC_G2M|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ZCCHC12 ASPM SMC4 CKAP2

2.49e-04184744d1e0e3b0eed2db8a5b7e3d6f81294667e4ba64e5
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m-Epithelial|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFAP43 CCDC180 MYCBPAP FREM1

2.49e-04184744d7eccbd21c480d907fdc8eff2bf5ae22ae452221
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m-Epithelial-neuroepithelial_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFAP43 CCDC180 MYCBPAP FREM1

2.49e-0418474422010cfe0428ebfa40952cc1a1a12ad3d25b35c9
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m-Epithelial-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFAP43 CCDC180 MYCBPAP FREM1

2.49e-04184744264e14aa1859cfc0ed5fb40e97ea189aed9ef4a5
ToppCellControl-T_cells-Cycling_NK/T_cells|Control / group, cell type (main and fine annotations)

AICDA ASPM SMC4 CKAP2

2.54e-041857449766216b41ee62bbac4caa25cb98ec5627a24075
ToppCellNS-moderate-d_16-33-Epithelial-Ciliated|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

DYNC2H1 CFAP43 CCDC180 MYCBPAP

2.54e-041857445e689c2fb36ce3ac2adc8d15f67107f21cf68868
ToppCellSmart-start-Cell-Wel_seq-Neoplastic-Stem-like-OPC-like-OPC-like_Prolif-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

ABCA12 ASPM SMC4 CKAP2

2.60e-0418674486d145f965c311189e7996390eef491642417c5c
ToppCellSubstantia_nigra-Neuronal|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

SLC9A5 PURA USP29 ELAVL2

2.60e-041867443f889083fcffe516388e9b03a5e23af2010ced33
ToppCellSubstantia_nigra-Neuronal-Inhibitory|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

SLC9A5 PURA USP29 ELAVL2

2.60e-041867449d3efe2a4feea2bc205a7e45b9b9f9ed9b3609ce
ToppCellfacs-Lung-EPCAM-3m-Epithelial-Ciliated_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HS6ST2 CFAP43 CCDC180 MYCBPAP

2.65e-0418774404dba2ed09ee4180830bdf0191921696697ea234
ToppCelldroplet-Lung-3m-Epithelial-airway_epithelial-lung_ciliated_cell-ciliated_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SEC14L3 HS6ST2 CFAP43 MYCBPAP

2.65e-041877441bba994aaaa9825b54aaeaff3829850267bc4602
ToppCellfacs-Lung-EPCAM-3m-Epithelial-ciliated_columnar_cell_of_tracheobronchial_tree|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HS6ST2 CFAP43 CCDC180 MYCBPAP

2.65e-04187744805dafe22f835ece4dd091d8030d0a63b52a48dd
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Macrophage_Dendritic-Cycling_Mononuclear_Phagocyte|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ASPM SMC4 DOCK10 CKAP2

2.65e-0418774473931a5ea73799095daff100b5f18853c57c74dc
ToppCelldroplet-Lung-3m-Epithelial-airway_epithelial-lung_ciliated_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SEC14L3 HS6ST2 CFAP43 MYCBPAP

2.65e-04187744d6ac351e7aeba98851d308c14ac395044fe4fbbb
ToppCellSubstantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

ZCCHC12 PURA USP29 ELAVL2

2.70e-04188744b73e8a40393c3f656e2fcfe395a761b1f985c254
ToppCellEpithelial-Epithelial-D_(Ciliated)|Epithelial / shred on cell class and cell subclass (v4)

SEC14L3 DYNC2H1 CFAP43 CCDC180

2.70e-041887448f30535a32968a81a304315a49c0d90a77d36948
ToppCellPND10-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated-Ciliated_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SEC14L3 HS6ST2 CFAP43 CCDC180

2.76e-0418974402c6128a9ab5818e0881dcadafdad5f08b9a67cf
ToppCellPND28-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated-Ciliated_mature|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SEC14L3 CFAP43 CCDC180 MYCBPAP

2.76e-04189744fa1ff8b7fa53f3148d9117d6e598097f03af5eb2
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

DYNC2H1 HS6ST2 USP24 FREM1

2.76e-041897447eb8f5a951e80f1cfac4d7c9eb169f4eb100c917
ToppCellE15.5-Mesenchymal-developing_mesenchymal_cell-mesenchymal_proliferating_cell|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

ASPM SMC4 CKAP2 FREM1

2.76e-04189744d049f33115610bda4489968759f754730698b9cd
ToppCellPND10-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SEC14L3 HS6ST2 CFAP43 CCDC180

2.76e-04189744164ea92ff6a1aa2ead1c9b8f64f99a9d65437232
ToppCelldroplet-Lung-3m-Epithelial-airway_epithelial|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SEC14L3 HS6ST2 CFAP43 MYCBPAP

2.76e-04189744a28e0922e10013ae79266f6a3f9305e6ee614d8b
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DYNC2H1 HS6ST2 USP24 FREM1

2.76e-04189744977a813e5d7a5a561c1fced2bbf21c20056b88d8
ToppCellPND28-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SEC14L3 CFAP43 CCDC180 MYCBPAP

2.76e-04189744565063f9e3dd79164321f8a394bd12c176baf202
ToppCellPND10-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SEC14L3 HS6ST2 CFAP43 CCDC180

2.76e-04189744a85099bd598a27ee64ee0664d051d89fa8d62fc9
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

DYNC2H1 HS6ST2 USP24 FREM1

2.76e-04189744975c0f079903ae36b0ffa54e86294d42ec7697de
ToppCellPND28-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SEC14L3 CFAP43 CCDC180 MYCBPAP

2.76e-04189744497be236848ebf5ad75d1f0c71e6261f5d3521da
ToppCellIPF-Myeloid-ncMonocyte|World / Disease state, Lineage and Cell class

CDH23 SRGAP2 SRGAP2B FKBP5

2.81e-04190744f9c2a13c7f6460e3b348581be855b7281c8f70b5
ToppCellpdx-Tumor_cells-T1|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

ASPM SMC4 CKAP2 FKBP5

2.81e-04190744d06ee5f89f1cec8db6897fe3b2a890a07cd3697b
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DYNC2H1 HS6ST2 USP24 FREM1

2.81e-04190744e252e925600e6457fa6e362a55217f4cffa75cdb
ToppCellfacs-Lung-3m-Epithelial-airway_epithelial-lung_ciliated_cell-ciliated_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

HS6ST2 CFAP43 CCDC180 MYCBPAP

2.87e-04191744649fcb62ad15de2f83e61591e43923a717664ae7
ToppCellfacs-Lung-3m-Epithelial-airway_epithelial-lung_ciliated_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

HS6ST2 CFAP43 CCDC180 MYCBPAP

2.87e-041917449621e22e14ea069f22713947c9faa2d882abe5fe
ToppCellEntopeduncular-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)|Entopeduncular / BrainAtlas - Mouse McCarroll V32

ZCCHC12 PURA USP29 ELAVL2

2.87e-041917445d24022cec293bc8d9e978ae99a109e660bb8f83
ToppCellEntopeduncular-Neuronal-Inhibitory|Entopeduncular / BrainAtlas - Mouse McCarroll V32

ZCCHC12 PURA USP29 ELAVL2

2.87e-0419174473dae4cdea86aec62393ad7303dc7375a6b3fc86
ToppCellfacs-Lung-3m-Epithelial-airway_epithelial|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

HS6ST2 CFAP43 CCDC180 MYCBPAP

2.87e-041917446a8fc9dc1a4c7115862e8f20204fa2f95e50e22f
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Immune-Myeloid-Macrophage_Dendritic|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK10 SRGAP2 SRGAP2B ADAP2

2.93e-0419274486d792682ba51696f503c79625dd20f87bcf651f
ToppCellRV-08._Macrophage|World / Chamber and Cluster_Paper

ASPM SRGAP2 SRGAP2B ADAP2

2.93e-04192744a1b5dc5beb97a23729b97b54fb4574d10d8fbfb3
ToppCellIPF-Myeloid-ncMonocyte|IPF / Disease state, Lineage and Cell class

CDH23 SRGAP2 SRGAP2B FKBP5

2.93e-04192744e9fb8c57d8094f70fb492909b2bec40aa5f2e5b8
ToppCellPND03-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SEC14L3 CFAP43 CCDC180 MYCBPAP

2.93e-04192744b5cdc2dae3154b1e4ade88f841f38584402ffe33
ToppCellH1299-infected|H1299 / Cell line, Condition and Strain

SRRT ASPM SMC4 PDCD11

2.93e-041927449cf8049bdc3e0f81ce69042beac72b08d8f38b4e
ToppCellLV-08._Macrophage|LV / Chamber and Cluster_Paper

SRGAP2 SRGAP2B FKBP5 ADAP2

2.93e-041927447be12d580aaf2f2f1562203fcad3a44639b8c5a6
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK10 SRGAP2 SRGAP2B ADAP2

2.93e-04192744d0ad6a205ad50a3c523fa68676996b289eabc5de
ToppCellEntopeduncular-Neuronal|Entopeduncular / BrainAtlas - Mouse McCarroll V32

ZCCHC12 PURA USP29 ELAVL2

2.93e-041927444c35e5c28a40b439044797ba1f06cb7c36b2a8de
ToppCellRV-08._Macrophage|RV / Chamber and Cluster_Paper

ASPM SRGAP2 SRGAP2B ADAP2

2.99e-0419374412bf98a280f87e4d8f0c6887dfc855da72e47ac1
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Immune-Myeloid|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK10 SRGAP2 SRGAP2B ADAP2

2.99e-04193744f597fefc54327a1ad136e2f66b6e81cc5c761eb7
ToppCellPCW_07-8.5|World / Celltypes from embryonic and fetal-stage human lung

ASPM SMC4 CKAP2 FKBP5

3.05e-041947445759c83308df017f1faae248e9b85388e25254f0
ToppCell3'-Child09-12-SmallIntestine-Hematopoietic-B_cells-Cycling_plasma_cell|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

AICDA ASPM SMC4 CKAP2

3.05e-0419474406b8dc2e46f833707d5b68b324b4ff6c4d0dccf9
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SRGAP2 SRGAP2B PKD1L3 ADAP2

3.05e-04194744c95d5c4ad0210ebd672926558cc8331e6396a854
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

AGBL4 DYNC2H1 CFAP43 CCDC180

3.05e-041947444a2c127c90d1fefe604fcb9e796577d21b489dd6
ToppCellCOPD-Myeloid-Macrophage|World / Disease state, Lineage and Cell class

SRGAP2 SRGAP2B DHX34 FKBP5

3.05e-041947447d682408e9a6239a4e47befc9376e760cc3d133a
ToppCellAdult-Immune-interstitial_macrophage_(C1Q_positive)-D231|Adult / Lineage, Cell type, age group and donor

MALT1 CDH23 ADAP2 TPCN1

3.05e-04194744800d3d7a9e864d2d6a100a4e4af22f45d5790a8d
ToppCellBronchial-NucSeq-Stromal-Mesofibroblastic-Mesothelia|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

AGBL4 GUCY2C ABCA12 NEB

3.17e-04196744ce13af36fc2932e8125013041742593ff3d07e86
ToppCellBronchial-NucSeq-Stromal-Mesofibroblastic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

AGBL4 GUCY2C ABCA12 NEB

3.17e-0419674496e5c6d155273e82ebafa180df8bb589c3e3e54e
ToppCellmLN-B_cell-B_cell_cycling|mLN / Region, Cell class and subclass

AICDA ASPM NEB FKBP4

3.23e-04197744806dddcca85c82bd642008d930c8db16b613d88e
ToppCell5'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SEC14L3 DYNC2H1 CFAP43 CCDC180

3.23e-0419774487db09f341e2b20eb6e1c3e917cb5c960387b3e9
ComputationalCytochrome P450.

CYP2C19 CYP2C8 CYP2C9 CYP2C18

2.60e-0714454MODULE_106
ComputationalGenes in the cancer module 135.

CYP2C19 CYP2C8 CYP2C18

1.48e-0425453MODULE_135
Drug4',5-dihydroxydiclofenac

CYP2C19 CYP2C8 CYP2C9 CYP2C18

1.53e-096744CID003052567
Drug3'-hydroxydiclofenac

CYP2C19 CYP2C8 CYP2C9 CYP2C18

1.53e-096744CID000112230
Drug5-hydroxydiclofenac

CYP2C19 CYP2C8 CYP2C9 CYP2C18

4.99e-0812744CID003052566
Drugpropionanilide

CYP2C19 CYP2C8 CYP2C9 STON1

1.00e-0714744CID000012107
Drug2'-(glutathion-S-yl)-deschlorodiclofenac

CYP2C19 CYP2C8 CYP2C9 CYP2C18

1.37e-0715744ctd:C586542
DrugAzamulinum

CYP2C19 CYP2C8 CYP2C9 CYP2C18

3.04e-0718744CID003086060
DrugD 703

CYP2C19 CYP2C8 CYP2C9 CYP2C18

3.04e-0718744CID000054088
Drugbufuralol

CYP2C19 CYP2C8 CYP2C9

3.28e-075743ctd:C010831
Drughydroxytolbutamide

CYP2C19 CYP2C8 CYP2C9 CYP2C18

3.84e-0719744CID000003656
Drug3C etc

CYP2C19 CYP2C8 CYP2C9 CYP2C18

4.79e-0720744CID000164045
Drug6-hydroxymelatonin

MALT1 CYP2C19 CYP2C8 CYP2C9 CYP2C18

5.98e-0750745CID000001864
Drug4,4'-cyclohexylidenebisphenol

CYP2C19 CYP2C8 CYP2C9

6.55e-076743ctd:C570106
DrugAC1O5Z5L

CYP2C19 CYP2C8 CYP2C9

6.55e-076743CID006443527
Drugtriazolam

MALT1 CYP2C19 CYP2C8 CYP2C9 CYP2C18

8.83e-0754745CID000005556
Drug5-fluorotryptamine

CYP2C19 CYP2C8 CYP2C9

1.14e-067743ctd:C034536
Drug6-Fluoro-6-desoxyoxymorphone

CYP2C19 CYP2C8 CYP2C9

1.14e-067743CID005486899
Drug16-O-demethylaconitine

CYP2C19 CYP2C8 CYP2C9

1.14e-067743ctd:C486136
DrugTolbutamide

CYP2C19 CYP2C8 CYP2C9 CYP2C18

1.23e-0625744ctd:D014044
Drug1,4-naphthoquinone

CYP2C19 CYP2C8 CYP2C9 CYP2C18

1.46e-0626744ctd:C035342
Drug13-hydroxyeicosatetraenoic acid

CYP2C19 CYP2C8 CYP2C9

1.82e-068743CID006439499
Drug11-HODE

CYP2C19 CYP2C8 CYP2C9

1.82e-068743CID006438497
Drug5-bromotryptamine

CYP2C19 CYP2C8 CYP2C9

1.82e-068743ctd:C040997
Drug1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid

CYP2C19 CYP2C8 CYP2C9

1.82e-068743ctd:C585955
Drug(hydrochloride)

CYP2C19 CYP2C8 CYP2C9 CYP2C18

2.30e-0629744CID000004923
Drug4,5-dihydropyrazole-1,5-dicarboxylic acid 1-((4-chlorophenyl)-amide) 5-(2-oxo-2H-(1,3')bipyridinyl-6'-yl)-amide

CYP2C19 CYP2C9 CYP2C18

2.73e-069743ctd:C545880
DrugAcenocoumarol

CYP2C19 CYP2C9 CYP2C18

2.73e-069743ctd:D000074
Drug5-chlorotryptamine

CYP2C19 CYP2C8 CYP2C9

2.73e-069743ctd:C529169
Drug3-(2-(4-(3-chloro-2-methylphenyl)1-piperazinyl)ethyl)5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazol dihydrochloride 3.5 hydrate

CYP2C19 CYP2C8 CYP2C9

2.73e-069743ctd:C109602
Drug5-(N-(4-((4-ethylbenzyl)thio)phenyl)sulfamoyl)-2-methylbenzoic acid

CYP2C19 CYP2C8 CYP2C9

2.73e-069743ctd:C000588958
DrugTryptamines

CYP2C19 CYP2C8 CYP2C9

2.73e-069743ctd:D014363
DrugBP-7,8-oxide

CYP2C19 CYP2C8 CYP2C9 CYP2C18

3.45e-0632744CID000037455
DrugDMEs

CYP2C19 CYP2C8 CYP2C9 CYP2C18 GBE1

3.48e-0671745CID003038361
Drugsitaxsentan

CYP2C19 CYP2C8 CYP2C9

3.89e-0610743ctd:C106276
Drugnorketobemidone

CYP2C19 CYP2C8 CYP2C9

3.89e-0610743CID000161154
DrugHaloperidol metabolite I

CYP2C19 CYP2C8 CYP2C9

5.34e-0611743CID000038282
Drugtrans-1,2-dihydro-1,2-naphthalenediol

CYP2C19 CYP2C8 CYP2C9

5.34e-0611743ctd:C507866
Drug4-(N-propionylanilino)piperidine

CYP2C19 CYP2C8 CYP2C9

7.10e-0612743CID000259381
Drugcarveol

CYP2C19 CYP2C8 CYP2C9

7.10e-0612743CID000007438
Drugdesethylamodiaquine

CYP2C19 CYP2C8 CYP2C9

7.10e-0612743ctd:C047386
Drugnorclozapine

CYP2C19 CYP2C8 CYP2C9

7.10e-0612743ctd:C058272
DrugAC1L18GM

CYP2C19 CYP2C8 CYP2C9

9.21e-0613743CID000000092
Drug7-hydroxyquinoline

CYP2C19 CYP2C8 CYP2C9

9.21e-0613743CID000011378
Drug1'-hydroxymidazolam

CYP2C19 CYP2C8 CYP2C9

9.21e-0613743CID000107917
Drugclozapine N-oxide

CYP2C19 CYP2C8 CYP2C9

9.21e-0613743CID000036727
Drugfurafylline

CYP2C19 CYP2C8 CYP2C9 CYP2C18

9.50e-0641744CID000003433
Drugdibenzylfluorescein

CYP2C19 CYP2C9

1.04e-052742ctd:C558664
Drug5-MeO-DIPT

CYP2C19 CYP2C8 CYP2C9

1.17e-0514743CID000151182
Drugsulfaphenazole

CYP2C19 CYP2C8 CYP2C9 CYP2C18

1.26e-0544744CID000005335
Drugpolybrominated biphenyl

CYP2C19 CYP2C8 CYP2C9 CYP2C18

1.26e-0544744CID000042948
Drug4-hydroxymephenytoin

CYP2C19 CYP2C8 CYP2C9

1.46e-0515743CID000119507
Drug4,4'-(hexafluoroisopropylidene)diphenol

CYP2C19 CYP2C8 CYP2C9

1.79e-0516743ctd:C571725
DrugAmodiaquine

CYP2C19 CYP2C8 CYP2C9

1.79e-0516743ctd:D000655
Drug6-hydroxychlorzoxazone

CYP2C19 CYP2C8 CYP2C9

1.79e-0516743CID000002734
Drug1-phenylazo-2-naphthol

CYP2C19 CYP2C8 CYP2C9

1.79e-0516743ctd:C024336
Drug1,1,1-trichloro-2-(4-hydroxyphenyl)-2-(4-methoxyphenyl)ethane

CYP2C19 CYP2C9 CYP2C18

1.79e-0516743ctd:C495657
Drugfelodipine

CYP2C19 CYP2C8 CYP2C9 CYP2C18 PKD1L3 TPCN1

1.87e-05169746CID000003333
Drug19-HETE

CYP2C19 CYP2C8 CYP2C9 CYP2C18

1.95e-0549744CID006439528
Drugdiosmetin

CYP2C19 CYP2C8 CYP2C9

2.17e-0517743ctd:C039602
Drugnoralfentanil

CYP2C8 CYP2C9 STON1

2.17e-0517743CID000162172
Drug7-benzyloxyquinoline

CYP2C19 CYP2C8 CYP2C9

2.60e-0518743CID003035604
Drugpleuromutilin

CYP2C19 CYP2C8 CYP2C9

2.60e-0518743CID000031326
Drug2,4-oxazolidinedione

CYP2C19 CYP2C8 CYP2C9

2.60e-0518743CID000097389
Drug17-AAG; Up 200; 1uM; MCF7; HT_HG-U133A

VPS9D1 SRRT ZNF155 CLCN6 DOCK10 ZNF222

2.67e-051807465203_UP
DrugD 617

CYP2C8 CYP2C9 CYP2C18

3.08e-0519743CID000093168
Drug6|A-Hydroxycortisol

CYP2C19 CYP2C8 CYP2C9

3.08e-0519743CID000150985
DrugFlumethasone [2135-17-3]; Up 200; 9.8uM; HL60; HT_HG-U133A

DOCK1 VPS9D1 ZNF155 DYNC2H1 DHX34 FKBP5

3.11e-051857462551_UP
Drug5-(4-(3-(4-cyclohexyl-2-propylphenoxy)propoxy)phenyl)-1,3-oxazolidine-2,4-dione

CYP2C19 CYP2C8

3.12e-053742ctd:C502236
Drugpicoxystrobin

CYP2C19 CYP2C9

3.12e-053742ctd:C556557
Drug2-hydroxychlorpropamide

CYP2C19 CYP2C9

3.12e-053742CID003082454
DrugCyclohexenes

CYP2C8 CYP2C9

3.12e-053742ctd:D053138
Drugmono-N-demethyladinazolam

CYP2C19 CYP2C9

3.12e-053742ctd:C050132
Drugortho-Aminobenzoates

CYP2C8 CYP2C9

3.12e-053742ctd:D062367
DrugDelavirdine

CYP2C19 CYP2C9

3.12e-053742ctd:D020008
DrugN'-nitrosoanatabine

CYP2C19 CYP2C8 CYP2C9

3.61e-0520743CID000051291
Drugtamoxifen N-oxide

CYP2C19 CYP2C8 CYP2C9

3.61e-0520743CID003033895
Drug3-methoxymorphinan

CYP2C19 CYP2C8 CYP2C9

3.61e-0520743CID000001671
DrugICI 182,780; Up 200; 0.01uM; MCF7; HT_HG-U133A

VPS9D1 STON1 DOCK10 GNAT2 NEB ZNF222

4.06e-051947465235_UP
DrugAC1L21VM

CYP2C19 CYP2C8 CYP2C9

4.20e-0521743CID000039524
Drugnirvanol

CYP2C19 CYP2C8 CYP2C9

4.20e-0521743CID000091480
Drugzafirlukast

CYP2C19 CYP2C8 CYP2C9

4.20e-0521743ctd:C062735
DrugNovobiocin sodium salt [1476-53-5]; Down 200; 6.4uM; MCF7; HT_HG-U133A

SRRT SLC9A5 ZNF224 RAPGEF2 FKBP5 ADAP2

4.29e-051967464392_DN
Drug1,1-dichloroethylene

KRT12 CYP2C8 CYP2C9 CYP2C18

4.37e-0560744CID000006366
DrugOndansetron Hydrochloride [103639-04-9]; Up 200; 12.2uM; MCF7; HT_HG-U133A

SRRT SLC9A5 CLCN6 SMC4 GNAT2 ANKZF1

4.54e-051987463575_UP
DrugLansoprazole

CYP2C19 CYP2C8 CYP2C9 CYP2C18

4.66e-0561744ctd:D064747
DrugBP-4,5-oxide

CYP2C19 CYP2C8 CYP2C9 CYP2C18

4.66e-0561744CID000037786
DrugN'-nitrosoanabasine

CYP2C19 CYP2C8 CYP2C9

4.85e-0522743CID000014335
Drugazoline

CYP2C19 CYP2C8 CYP2C9

4.85e-0522743CID003013050
Drugchlorzoxazone

CYP2C19 CYP2C8 CYP2C9 CYP2C18

5.30e-0563744CID000002733
Drug3-hydroxymethylantipyrine

CYP2C8 CYP2C9 CYP2C18

5.57e-0523743CID000123963
Drug3'-amino-3'-deoxythymidine

CYP2C19 CYP2C8 CYP2C9

5.57e-0523743CID000108074
Drugthiocoraline

CYP2C8 CYP2C9

6.23e-054742ctd:C109005
Drug1-(6-((2-(dimethylamino)ethyl)(methyl)amino)-1,3-dimethyl-1H-pyrazolo(3,4-b)pyridine-5-carbonyl)-3-(3-isopropoxyphenyl)urea

CYP2C19 CYP2C9

6.23e-054742ctd:C558737
Drug4-isopropylphenol

CYP2C8 CYP2C9

6.23e-054742ctd:C028690
Drug7,8-dihydromethysticin

CYP2C19 CYP2C9

6.23e-054742ctd:C107882
Drugmethysticin

CYP2C19 CYP2C9

6.23e-054742ctd:C076881
DrugSulfadiazine

CYP2C8 CYP2C9

6.23e-054742ctd:D013411
Drugrabeprazole-thioether

CYP2C19 CYP2C9

6.23e-054742ctd:C523099
DrugN-nitrosomethylethylamine

CYP2C19 CYP2C8 CYP2C9

6.35e-0524743CID000025418
Drug5-hydroxythalidomide

CYP2C19 CYP2C18 UQCRB

6.35e-0524743ctd:C544471
Drugcinnamic acid

CYP2C19 CYP2C8 CYP2C9

6.35e-0524743ctd:C029010
DiseaseX-21258 measurement

CYP2C19 CYP2C9 CYP2C18

1.39e-083723EFO_0800802
DiseaseX-14473 measurement

CYP2C19 CYP2C18

5.87e-062722EFO_0021370
Diseasecyclo(leu-pro) measurement

CYP2C19 CYP2C18

1.76e-053722EFO_0800676
DiseaseS-6-hydroxywarfarin to S-warfarin ratio measurement

CYP2C19 CYP2C8 CYP2C9 CYP2C18

6.51e-0588724EFO_0803332
DiseaseS-warfarin to R-warfarin ratio measurement

CYP2C19 CYP2C8 CYP2C9 CYP2C18

8.77e-0595724EFO_0803331
Diseaseglycine conjugate of C10H14O2 (1) measurement

CYP2C9 CYP2C18

1.22e-047722EFO_0800655
Diseaseplasma clozapine-to-N-desmethylclozapine ratio measurement

CYP2C19 CYP2C18

2.09e-049722EFO_0600040
DiseaseX-11308 measurement

CYP2C19 CYP2C9

3.18e-0411722EFO_0800693
DiseaseMajor Depressive Disorder

SRRT CYP2C19 CYP2C9 FKBP4 FKBP5

3.25e-04243725C1269683
Diseaseecosanoids measurement

CYP2C8 CYP2C9 CYP2C18

3.34e-0455723EFO_0020044
Diseasethymol sulfate measurement

CYP2C19 CYP2C9

3.81e-0412722EFO_0021170
DiseaseUnipolar Depression

SRRT CYP2C19 CYP2C9 FKBP4 FKBP5

4.34e-04259725C0041696
Diseasetetralogy of Fallot (implicated_via_orthology)

DOCK1 PHC1

5.24e-0414722DOID:6419 (implicated_via_orthology)
Disease16a-hydroxy DHEA 3-sulfate measurement

CYP2C8 CYP2C9

6.04e-0415722EFO_0800301
DiseaseAutosomal recessive primary microcephaly

ASPM PHC1

6.04e-0415722cv:C3711387
Diseaseandro steroid monosulfate C19H28O6S (1) measurement

CYP2C8 CYP2C9

6.89e-0416722EFO_0800305
Diseasemetabolonic lactone sulfate measurement

CYP2C9 CYP2C18

9.77e-0419722EFO_0800659
DiseasePrimary microcephaly

ASPM PHC1

1.31e-0322722C0431350
DiseaseAutosomal Recessive Primary Microcephaly

ASPM PHC1

1.31e-0322722C3711387
Diseaseplatelet reactivity measurement, response to clopidogrel

CYP2C19 CYP2C18

1.44e-0323722EFO_0004985, GO_1903493
DiseaseDisorder of eye

CDH23 BBS5 GNAT2 FREM1

1.82e-03212724C0015397

Protein segments in the cluster

PeptideGeneStartEntry
QYRMQRDKEFRLKQS

ATP6V1G3

46

Q96LB4
MYRDFKLRSALIQNK

BBS5

136

Q8N3I7
IQMLFFSRDRQKYLN

CFAP43

1521

Q8NDM7
NFLLRVNMSKYDAAR

ABCA12

1946

Q86UK0
MDSLLMNRRKFLYQF

AICDA

1

Q9GZX7
RFDYKDQNFLTLMKR

CYP2C8

186

P10632
RFRLDNLLNMAYGVK

ELAVL3

236

Q14576
NVRSKNFRLKIYDME

CCDC180

971

Q9P1Z9
DYLRLKKLFAQRMVQ

CDH23

3221

Q9H251
MKERNIQFQRYNKLR

ASPM

2226

Q8IZT6
NALRAARLQYLKMAF

ADAP2

226

Q9NPF8
RRKTLFAYKQENEML

CKAP2

36

Q8WWK9
YNDRMFRIKRALDLN

UQCRB

56

P14927
YKAERDRADRLNFML

GUCY2C

786

P25092
RRIYANMFKKFAEQD

FKBP5

406

Q13451
SRLDLRYINFKMANL

KCTD9

231

Q7L273
NARLAAEDFRMKYEN

KRT12

206

Q99456
LNVFLLDMCRKRNDY

MALT1

456

Q9UDY8
TAFRQYRMNKNFERL

IQSEC2

356

Q5JU85
ALANKMGLKFQRYRL

BECN1

316

Q14457
LFKNEMKRRRDFYAA

BMI1

86

P35226
KNLLRFDYDRMASLE

FREM1

156

Q5H8C1
KINNMYRFSLAAFLR

DYNC2H1

3511

Q8NCM8
FNCLNKRLAKYRMRN

CLCN6

351

P51797
RYKFLNNFDRDMNRL

GBE1

576

Q04446
RFDYKDQQFLNLMEK

CYP2C19

186

P33261
NRLRKYAFELKMNDL

DOCK10

251

Q96BY6
FLRAINQYADMLNKK

DOCK1

996

Q14185
RNEFRRFMEKNPDAY

ANKZF1

581

Q9H8Y5
LQKRNMDYFFREQLG

AGBL4

181

Q5VU57
RFRLDNLLNMAYGVK

ELAVL2

236

Q12926
AKDLFLQRYQFMRQK

HS6ST2

491

Q96MM7
RFDYKDQRFLNLMEK

CYP2C18

186

P33260
RFDYKDQQFLNLMEK

CYP2C9

186

P11712
RRQLAREKKLYANMF

FKBP4

401

Q02790
RLYEMANLRRQFKEL

DHX34

676

Q14147
NFDLQKSEALLRKYM

SEC14L3

46

Q9UDX4
IFASNLKERMAQRFY

BYSL

236

Q13895
NRKFLMQELYQRFLD

KIF28P

601

B7ZC32
FIYSLRNRDMKAALR

OR1A1

286

Q9P1Q5
QKRAEMFLSQFNRYN

MEIOC

306

A2RUB1
LKDNFQDQMKRELAY

SKOR1

886

P84550
NYIKSQFLDLNMRKD

GNAT2

301

P19087
KLHYKEFRRFMENLQ

MICU2

246

Q8IYU8
KKNMARYRDDQDRFI

PKD1L3

1526

Q7Z443
EQFDKKYLSQLLMRR

SLC9A5

501

Q14940
MDYSRNLEKLAERFL

SRGAP2B

61

P0DMP2
LKIDEYMRNFSDLRN

PPM1B

111

O75688
RYNDYKLDFRRQQMQ

SRRT

171

Q9BXP5
FLNAKKLYEDAQMAR

RAPGEF2

961

Q9Y4G8
LDFRMRLAEVQRQYK

TNRC18

1481

O15417
KFQEAGELYNRMLKR

PDCD11

1706

Q14690
KLYRDVMLENFRNLL

ZNF223

31

Q9UK11
KNLYKDVMLENFRNL

ZNF177

36

Q13360
RFELMRFKTLYNGDN

STON1

511

Q9Y6Q2
LYRINAQMKAFRKEL

SOGA3

871

Q5TF21
MDYSRNLEKLAERFL

SRGAP2

61

O75044
KLSYRDAKQLNMFLD

USP29

86

Q9HBJ7
KNLYRDVMRETFRNL

ZNF627

26

Q7L945
FQDLKKNRMQRFYFD

MYCBPAP

471

Q8TBZ2
DLRKQRLNEFMAGFY

SMC4

1126

Q9NTJ3
KMKEFQEANYARVRR

PHC1

841

P78364
ILEAFVFRMNYSRKN

TPCN1

686

Q9ULQ1
KLYRDVMLENFRNLL

ZNF112

31

Q9UJU3
RDENLKFMKNRDVYS

USP24

2121

Q9UPU5
MFFNKDLRRNKAALL

XKR3

86

Q5GH77
KLYRDVMLENFRNLL

ZNF155

31

Q12901
NQKLKAAYEARMARL

VPS9D1

156

Q9Y2B5
KLYRDVMLENFRNLL

ZNF224

31

Q9NZL3
RFAKNYQQLQRDFME

UBR2

391

Q8IWV8
YMDLKENQRGRFLRI

PURA

156

Q00577
RLKDFLRMYANEQER

ZCCHC12

191

Q6PEW1
KLYRDVMLENFRNLL

ZNF222

31

Q9UK12
KLYRDVMLENFRNLL

ZNF284

31

Q2VY69
CLDFQKMRSALNYRK

NEB

4521

P20929