Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	protein localization to M-band	ANK2 OBSCN	1.52e-05	2	81	2	GO:0036309
Domain	zf-C2H2	SP3 ZNF138 ZNF773 ZNF486 ZNF296 ZNF781 ZNF197 ZNF432 ZNF214 ZNF275 ZNF541 ZFX ZNF461	7.20e-06	693	80	13	PF00096
Domain	ZINC_FINGER_C2H2_2	SP3 ZNF138 ZNF773 ZNF486 ZNF296 ZNF781 ZNF197 ZNF432 ZNF214 ZNF275 ZNF541 ZFX ZNF461	2.36e-05	775	80	13	PS50157
Domain	ZINC_FINGER_C2H2_1	SP3 ZNF138 ZNF773 ZNF486 ZNF296 ZNF781 ZNF197 ZNF432 ZNF214 ZNF275 ZNF541 ZFX ZNF461	2.42e-05	777	80	13	PS00028
Domain	-	SP3 ZNF138 ZNF773 ZNF486 ZNF296 ZNF781 ZNF197 ZNF432 ZNF214 ZNF541 ZFX ZNF461	3.03e-05	679	80	12	3.30.160.60
Domain	Znf_C2H2	SP3 ZNF138 ZNF773 ZNF486 ZNF296 ZNF781 ZNF197 ZNF432 ZNF214 ZNF275 ZNF541 ZFX ZNF461	3.50e-05	805	80	13	IPR007087
Domain	ZnF_C2H2	SP3 ZNF138 ZNF773 ZNF486 ZNF296 ZNF781 ZNF197 ZNF432 ZNF214 ZNF275 ZNF541 ZFX ZNF461	3.64e-05	808	80	13	SM00355
Domain	Znf_C2H2/integrase_DNA-bd	SP3 ZNF138 ZNF773 ZNF486 ZNF296 ZNF781 ZNF197 ZNF432 ZNF214 ZNF541 ZFX ZNF461	3.75e-05	694	80	12	IPR013087
Domain	Znf_C2H2-like	SP3 ZNF138 ZNF773 ZNF486 ZNF296 ZNF781 ZNF197 ZNF432 ZNF214 ZNF541 ZFX ZNF461	1.39e-04	796	80	12	IPR015880
Domain	KRAB	ZNF773 ZNF486 ZNF197 ZNF432 KRBA2 ZNF214 ZNF275 ZNF461	1.47e-04	358	80	8	PS50805
Domain	KRAB	ZNF773 ZNF486 ZNF197 ZNF432 KRBA2 ZNF214 ZNF275 ZNF461	1.47e-04	358	80	8	PF01352
Domain	KRAB	ZNF773 ZNF486 ZNF197 ZNF432 KRBA2 ZNF214 ZNF275 ZNF461	1.81e-04	369	80	8	SM00349
Domain	KRAB	ZNF773 ZNF486 ZNF197 ZNF432 KRBA2 ZNF214 ZNF275 ZNF461	1.84e-04	370	80	8	IPR001909
Domain	HECT	SMURF1 HERC4 SMURF2	2.06e-04	27	80	3	PF00632
Domain	HECTc	SMURF1 HERC4 SMURF2	2.06e-04	27	80	3	SM00119
Domain	HECT_dom	SMURF1 HERC4 SMURF2	2.06e-04	27	80	3	IPR000569
Domain	HECT	SMURF1 HERC4 SMURF2	2.06e-04	27	80	3	PS50237
Domain	MYB_LIKE	BDP1 MIDEAS ZNF541	5.73e-04	38	80	3	PS50090
Domain	Znf_CXXC	KDM2B KMT2A	9.72e-04	11	80	2	IPR002857
Domain	ZF_CXXC	KDM2B KMT2A	9.72e-04	11	80	2	PS51058
Domain	zf-CXXC	KDM2B KMT2A	9.72e-04	11	80	2	PF02008
Domain	CENPB	JRK TIGD4	1.16e-03	12	80	2	SM00674
Domain	DDE_1	JRK TIGD4	1.16e-03	12	80	2	PF03184
Domain	DDE_SF_endonuclease_dom	JRK TIGD4	1.16e-03	12	80	2	IPR004875
Domain	SANT	BDP1 MIDEAS ZNF541	1.28e-03	50	80	3	SM00717
Domain	ELM2	MIDEAS ZNF541	1.37e-03	13	80	2	PF01448
Domain	HTH_CENPB	JRK TIGD4	1.37e-03	13	80	2	PS51253
Domain	ELM2	MIDEAS ZNF541	1.37e-03	13	80	2	PS51156
Domain	ELM2_dom	MIDEAS ZNF541	1.37e-03	13	80	2	IPR000949
Domain	ELM2	MIDEAS ZNF541	1.37e-03	13	80	2	SM01189
Domain	HTH_CenpB_DNA-bd_dom	JRK TIGD4	1.37e-03	13	80	2	IPR006600
Domain	SANT/Myb	BDP1 MIDEAS ZNF541	1.44e-03	52	80	3	IPR001005
Domain	Dynein_heavy_chain_D4_dom	DNAH12 DNAH7	1.59e-03	14	80	2	IPR024317
Domain	Dynein_heavy_dom-2	DNAH12 DNAH7	1.59e-03	14	80	2	IPR013602
Domain	Znf_UBP	USP22 USP16	1.59e-03	14	80	2	IPR001607
Domain	DHC_N2	DNAH12 DNAH7	1.59e-03	14	80	2	PF08393
Domain	AAA_8	DNAH12 DNAH7	1.59e-03	14	80	2	PF12780
Domain	zf-UBP	USP22 USP16	1.59e-03	14	80	2	PF02148
Domain	ZF_UBP	USP22 USP16	1.59e-03	14	80	2	PS50271
Domain	DHC_fam	DNAH12 DNAH7	1.83e-03	15	80	2	IPR026983
Domain	Dynein_heavy_dom	DNAH12 DNAH7	1.83e-03	15	80	2	IPR004273
Domain	Dynein_heavy	DNAH12 DNAH7	1.83e-03	15	80	2	PF03028
Domain	zf-C2H2_6	ZNF773 ZNF486 ZNF197 ZNF432 ZNF541 ZNF461	2.28e-03	314	80	6	PF13912
Domain	USP_CS	USP10 USP22 USP16	2.85e-03	66	80	3	IPR018200
Domain	USP_1	USP10 USP22 USP16	3.37e-03	70	80	3	PS00972
Domain	UCH	USP10 USP22 USP16	3.51e-03	71	80	3	PF00443
Domain	USP_2	USP10 USP22 USP16	3.51e-03	71	80	3	PS00973
Domain	USP_3	USP10 USP22 USP16	3.65e-03	72	80	3	PS50235
Domain	USP_dom	USP10 USP22 USP16	3.65e-03	72	80	3	IPR028889
Domain	Peptidase_C19_UCH	USP10 USP22 USP16	3.65e-03	72	80	3	IPR001394
Domain	fn3	DSCAM OBSCN IL23R EPHA1	5.17e-03	162	80	4	PF00041
Domain	SANT_dom	MIDEAS ZNF541	5.51e-03	26	80	2	IPR017884
Domain	SANT	MIDEAS ZNF541	6.37e-03	28	80	2	PS51293
Domain	PH	OSBPL1A OBSCN GRB7 PLEK TIAM2	6.84e-03	278	80	5	SM00233
Domain	PH_DOMAIN	OSBPL1A OBSCN GRB7 PLEK TIAM2	6.94e-03	279	80	5	PS50003
Domain	PH_domain	OSBPL1A OBSCN GRB7 PLEK TIAM2	7.04e-03	280	80	5	IPR001849
Domain	FN3	DSCAM OBSCN IL23R EPHA1	8.21e-03	185	80	4	SM00060
Pubmed	HECT E3 Ubiquitin Ligase Itch Functions as a Novel Negative Regulator of Gli-Similar 3 (Glis3) Transcriptional Activity.	HIPK3 SMURF1 SMURF2	4.85e-06	14	84	3	26147758
Pubmed	The functions and regulation of Smurfs in cancers.	SMURF1 SMURF2	5.76e-06	2	84	2	31899247
Pubmed	Smurf2 induces ubiquitin-dependent degradation of Smurf1 to prevent migration of breast cancer cells.	SMURF1 SMURF2	5.76e-06	2	84	2	18927080
Pubmed	CD5L/AIM Regulates Lipid Biosynthesis and Restrains Th17 Cell Pathogenicity.	CD5L IL23R	5.76e-06	2	84	2	26607793
Pubmed	A case of pediatric acute myeloid leukemia with t(11;16)(q23;q24) leading to a novel KMT2A-USP10 fusion gene.	USP10 KMT2A	5.76e-06	2	84	2	30107050
Pubmed	SMURF1 and SMURF2 in Progenitor Cells from Articular Cartilage and Meniscus during Late-Stage Osteoarthritis.	SMURF1 SMURF2	5.76e-06	2	84	2	33090007
Pubmed	SP3 acts as a positive regulator on the core promoter of human ZPK gene.	SP3 MAP3K12	1.73e-05	3	84	2	14697235
Pubmed	Smurf1 and Smurf2 mediated polyubiquitination and degradation of RNF220 suppresses Shh-group medulloblastoma.	SMURF1 SMURF2	1.73e-05	3	84	2	37537194
Pubmed	Obscurin targets ankyrin-B and protein phosphatase 2A to the cardiac M-line.	ANK2 OBSCN	1.73e-05	3	84	2	18782775
Pubmed	The Smurf ubiquitin ligases regulate tissue separation via antagonistic interactions with ephrinB1.	SMURF1 SMURF2	1.73e-05	3	84	2	23475958
Pubmed	Binding of an ankyrin-1 isoform to obscurin suggests a molecular link between the sarcoplasmic reticulum and myofibrils in striated muscles.	ANK2 OBSCN	1.73e-05	3	84	2	12527750
Pubmed	Bortezomib prevents oncogenesis and bone metastasis of prostate cancer by inhibiting WWP1, Smurf1 and Smurf2.	SMURF1 SMURF2	1.73e-05	3	84	2	25051198
Pubmed	USF2 inhibits the transcriptional activity of Smurf1 and Smurf2 to promote breast cancer tumorigenesis.	SMURF1 SMURF2	1.73e-05	3	84	2	30244169
Pubmed	Down-regulation of Smad7 expression by ubiquitin-dependent degradation contributes to renal fibrosis in obstructive nephropathy in mice.	SMURF1 SMURF2	1.73e-05	3	84	2	15173588
Pubmed	Requirement of Smurf-mediated endocytosis of Patched1 in sonic hedgehog signal reception.	SMURF1 SMURF2	1.73e-05	3	84	2	24925320
Pubmed	System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.	SMURF1 HERC4 SMURF2	3.39e-05	26	84	3	26949039
Pubmed	Non-proteolytic ubiquitin modification of PPARγ by Smurf1 protects the liver from steatosis.	SMURF1 SMURF2	3.45e-05	4	84	2	30566427
Pubmed	Long non-coding RNA ARHGAP5-AS1 inhibits migration of breast cancer cell via stabilizing SMAD7 protein.	SMURF1 SMURF2	3.45e-05	4	84	2	34370213
Pubmed	Tumor necrosis factor promotes Runx2 degradation through up-regulation of Smurf1 and Smurf2 in osteoblasts.	SMURF1 SMURF2	3.45e-05	4	84	2	16373342
Pubmed	Nedd8 targets ubiquitin ligase Smurf2 for neddylation and promote its degradation.	SMURF1 SMURF2	3.45e-05	4	84	2	27086113
Pubmed	The WW1 Domain Enhances Autoinhibition in Smurf Ubiquitin Ligases.	SMURF1 SMURF2	3.45e-05	4	84	2	31628949
Pubmed	Human and mouse proteases: a comparative genomic approach.	USP10 USP22 OVCH1 USP16	4.57e-05	81	84	4	12838346
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	HIPK3 BDP1 UBR2 USP10 POLR1A OBSCN SMURF1 GREB1 TNFAIP8 SMOC2 MAP3K12 SMURF2 ZNF461	5.68e-05	1489	84	13	28611215
Pubmed	An integrated bioinformatics platform for investigating the human E3 ubiquitin ligase-substrate interaction network.	SMURF1 SMURF2	5.74e-05	5	84	2	28839186
Pubmed	Impaired Smad7-Smurf-mediated negative regulation of TGF-beta signaling in scleroderma fibroblasts.	SMURF1 SMURF2	5.74e-05	5	84	2	14722617
Pubmed	Pivotal role of the C2 domain of the Smurf1 ubiquitin ligase in substrate selection.	SMURF1 SMURF2	5.74e-05	5	84	2	21402695
Pubmed	NEDD4-family E3 ligase dysfunction due to PKHD1/Pkhd1 defects suggests a mechanistic model for ARPKD pathobiology.	SMURF1 SMURF2	5.74e-05	5	84	2	28798345
Pubmed	USP10 deubiquitylates the histone variant H2A.Z and both are required for androgen receptor-mediated gene activation.	USP10 USP16	5.74e-05	5	84	2	21245042
Pubmed	Coupling of tandem Smad ubiquitination regulatory factor (Smurf) WW domains modulates target specificity.	SMURF1 SMURF2	5.74e-05	5	84	2	20937913
Pubmed	Inhibition of HECT E3 ligases as potential therapy for COVID-19.	SMURF1 SMURF2	5.74e-05	5	84	2	33762578
Pubmed	HERC5/IFI16/p53 signaling mediates breast cancer cell proliferation and migration.	CUL4B UBR2 SMURF1 SMURF2	6.91e-05	90	84	4	35671810
Pubmed	Smad6-specific recruitment of Smurf E3 ligases mediates TGF-β1-induced degradation of MyD88 in TLR4 signalling.	SMURF1 SMURF2	8.59e-05	6	84	2	21897371
Pubmed	ICAP-1 monoubiquitylation coordinates matrix density and rigidity sensing for cell migration through ROCK2-MRCKα balance.	SMURF1 SMURF2	8.59e-05	6	84	2	28049720
Pubmed	Cerebral cavernous malformation 2 protein promotes smad ubiquitin regulatory factor 1-mediated RhoA degradation in endothelial cells.	SMURF1 SMURF2	8.59e-05	6	84	2	19318350
Pubmed	Structural basis for the versatile interactions of Smad7 with regulator WW domains in TGF-β Pathways.	SMURF1 SMURF2	8.59e-05	6	84	2	22921829
Pubmed	Ubiquitination-mediated degradation of SIRT1 by SMURF2 suppresses CRC cell proliferation and tumorigenesis.	SMURF1 SMURF2	8.59e-05	6	84	2	32361710
Pubmed	Hepatitis C virus/human interactome identifies SMURF2 and the viral protease as critical elements for the control of TGF-β signaling.	SMURF1 SMURF2	8.59e-05	6	84	2	23781096
Pubmed	Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	OBSCN SMURF1 HERC4 EPG5	1.08e-04	101	84	4	10997877
Pubmed	CHIP mediates degradation of Smad proteins and potentially regulates Smad-induced transcription.	SMURF1 SMURF2	1.20e-04	7	84	2	14701756
Pubmed	A cell-based high-throughput screening method based on a ubiquitin-reference technique for identifying modulators of E3 ligases.	SMURF1 SMURF2	1.20e-04	7	84	2	30587574
Pubmed	SET9-Mediated Regulation of TGF-β Signaling Links Protein Methylation to Pulmonary Fibrosis.	SMURF1 SMURF2	1.20e-04	7	84	2	27292644
Pubmed	The Nedd8 Non-covalent Binding Region in the Smurf HECT Domain is Critical to its Ubiquitn Ligase Function.	SMURF1 SMURF2	1.20e-04	7	84	2	28169289
Pubmed	A role for ubiquitin ligases and Spartin/SPG20 in lipid droplet turnover.	SMURF1 SMURF2	1.60e-04	8	84	2	19307600
Pubmed	Selective compounds enhance osteoblastic activity by targeting HECT domain of ubiquitin ligase Smurf1.	SMURF1 SMURF2	1.60e-04	8	84	2	28881580
Pubmed	An integrative pan-cancer analysis of biological and clinical impacts underlying ubiquitin-specific-processing proteases.	USP10 USP22	1.60e-04	8	84	2	31511647
Pubmed	Smad ubiquitylation regulatory factor 1/2 (Smurf1/2) promotes p53 degradation by stabilizing the E3 ligase MDM2.	SMURF1 SMURF2	1.60e-04	8	84	2	20484049
Pubmed	Structure, chromosomal location, and expression pattern of three mouse genes homologous to the human MAGE genes.	ZNF275 ZFX	2.05e-04	9	84	2	7590750
Pubmed	Formin 2 Regulates Lysosomal Degradation of Wnt-Associated β-Catenin in Neural Progenitors.	SMURF1 SMURF2	2.05e-04	9	84	2	29659741
Pubmed	Negative regulation of transforming growth factor-beta (TGF-beta) signaling by WW domain-containing protein 1 (WWP1).	SMURF1 SMURF2	2.56e-04	10	84	2	15221015
Pubmed	Patched-1 proapoptotic activity is downregulated by modification of K1413 by the E3 ubiquitin-protein ligase Itchy homolog.	SMURF1 SMURF2	2.56e-04	10	84	2	25092867
Pubmed	DNA Sequence Recognition of Human CXXC Domains and Their Structural Determinants.	KDM2B KMT2A	2.56e-04	10	84	2	29276034
Pubmed	Transforming growth factor-beta stimulates p300-dependent RUNX3 acetylation, which inhibits ubiquitination-mediated degradation.	SMURF1 SMURF2	2.56e-04	10	84	2	15138260
Pubmed	Damage-induced ubiquitylation of human RNA polymerase II by the ubiquitin ligase Nedd4, but not Cockayne syndrome proteins or BRCA1.	SMURF1 SMURF2	3.13e-04	11	84	2	17996703
Pubmed	USP11 augments TGFβ signalling by deubiquitylating ALK5.	SMURF1 SMURF2	3.13e-04	11	84	2	22773947
Pubmed	NEDD4 E3 ligase inhibits the activity of the Hippo pathway by targeting LATS1 for degradation.	SMURF1 SMURF2	3.75e-04	12	84	2	24107629
Pubmed	The construction of human somatic cell hybrids containing portions of the mouse X chromosome and their use to generate DNA probes via interspersed repetitive sequence polymerase chain reaction.	ZNF275 ZFX	3.75e-04	12	84	2	1916827
Pubmed	A protein interaction network for Ecm29 links the 26 S proteasome to molecular motors and endosomal components.	ANK2 KDM2B RNF217	4.21e-04	60	84	3	20682791
Pubmed	Localization of murine X and autosomal sequences homologous to the human Y located testis-determining region.	ZNF275 ZFX	4.42e-04	13	84	2	2721933
Pubmed	Genome-wide CRISPR-cas9 knockout screening identifies GRB7 as a driver for MEK inhibitor resistance in KRAS mutant colon cancer.	USP10 NOC2L GRB7	4.86e-04	63	84	3	34718347
Pubmed	TSC-22 promotes transforming growth factor β-mediated cardiac myofibroblast differentiation by antagonizing Smad7 activity.	SMURF1 SMURF2	5.15e-04	14	84	2	21791611
Pubmed	Identifying the ubiquitination targets of E6AP by orthogonal ubiquitin transfer.	SMURF1 SMURF2	5.15e-04	14	84	2	29263404
Pubmed	Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene.	DNAH12 DNAH7	5.15e-04	14	84	2	9373155
Pubmed	Deubiquitinating enzymes: a new class of biological regulators.	USP10 USP16	5.93e-04	15	84	2	9827704
Pubmed	Image-based genome-wide siRNA screen identifies selective autophagy factors.	OBSCN SMURF1 ZCCHC17 MAP3K12	6.11e-04	159	84	4	22020285
Pubmed	Expression of metanephric nephron-patterning genes in differentiating mesonephric tubules.	GPD1 SPDYA GREB1	6.35e-04	69	84	3	21491542
Pubmed	Assembly and structure of Lys33-linked polyubiquitin reveals distinct conformations.	SMURF1 SMURF2	6.77e-04	16	84	2	25723849
Pubmed	A human ubiquitin conjugating enzyme (E2)-HECT E3 ligase structure-function screen.	SMURF1 HERC4	6.77e-04	16	84	2	22496338
Pubmed	RNF11 sequestration of the E3 ligase SMURF2 on membranes antagonizes SMAD7 down-regulation of transforming growth factor β signaling.	SMURF1 SMURF2	7.66e-04	17	84	2	28292929
Pubmed	A strategy for modulation of enzymes in the ubiquitin system.	USP10 USP16	7.66e-04	17	84	2	23287719
Pubmed	SCFFBXL¹⁵ regulates BMP signalling by directing the degradation of HECT-type ubiquitin ligase Smurf1.	SMURF1 SMURF2	9.60e-04	19	84	2	21572392
Pubmed	Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system.	UBR2 RNF217 SMURF2	1.16e-03	85	84	3	19028597
Pubmed	Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition.	KDM2B KMT2A	1.17e-03	21	84	2	27626377
Pubmed	Cytoplasmic YAP1-mediated ESCRT-III assembly promotes autophagic cell death and is ubiquitinated by NEDD4L in breast cancer.	SMURF1 SMURF2	1.17e-03	21	84	2	37005481
Pubmed	USP16-mediated histone H2A lysine-119 deubiquitination during oocyte maturation is a prerequisite for zygotic genome activation.	USP22 USP16	1.29e-03	22	84	2	35640597
Pubmed	Confirmation of multiple Crohn's disease susceptibility loci in a large Dutch-Belgian cohort.	DNAH12 IL23R	1.29e-03	22	84	2	19174780
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	BDP1 DNAH12 POLR1A COL6A6 OBSCN KMT2A	1.31e-03	497	84	6	36774506
Pubmed	Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.	USP10 SP3 ZNF486 CFAP97D1 SMURF1 KMT2A HSD11B1L USP16 NDUFS2 ZFX	1.35e-03	1327	84	10	32694731
Pubmed	Bone morphogenetic proteins.	SMURF1 SMURF2	1.41e-03	23	84	2	15621726
Pubmed	Molecular reclassification of Crohn's disease by cluster analysis of genetic variants.	DNAH12 IL23R	1.41e-03	23	84	2	20886065
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	CUL4B NOC2L KMT2A GREB1 MIDEAS	1.44e-03	341	84	5	32971831
Pubmed	Genome-wide association study of proneness to anger.	HIPK3 PLEK	1.54e-03	24	84	2	24489884
Pubmed	Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity.	UBR2 SMURF1 HERC4	1.60e-03	95	84	3	29643511
Pubmed	Regulation of planar cell polarity by Smurf ubiquitin ligases.	SMURF1 SMURF2	1.67e-03	25	84	2	19379695
Pubmed	Bmp2 and Notch cooperate to pattern the embryonic endocardium.	SMURF1 SMURF2	1.80e-03	26	84	2	29853617
Pubmed	Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.	CUL4B HIPK3 TTBK1 DSTN SMURF1 KMT2A SMURF2	1.95e-03	730	84	7	34857952
Pubmed	SIRT1 coordinates with the CRL4B complex to regulate pancreatic cancer stem cells to promote tumorigenesis.	CUL4B USP22	2.09e-03	28	84	2	34163012
Pubmed	Genetic risk profiling and prediction of disease course in Crohn's disease patients.	DNAH12 IL23R	2.09e-03	28	84	2	19422935
Pubmed	GREB1: An evolutionarily conserved protein with a glycosyltransferase domain links ERα glycosylation and stability to cancer.	USP10 DSTN GREB1 MIDEAS	2.13e-03	223	84	4	33731348
Pubmed	Systematic identification of cancer cell vulnerabilities to natural killer cell-mediated immune surveillance.	CUL4B JRK OBSCN IRAG2	2.23e-03	226	84	4	31452512
Pubmed	TRAF4 promotes TGF-β receptor signaling and drives breast cancer metastasis.	SMURF1 SMURF2	2.40e-03	30	84	2	23973329
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	SP3 ZNF138 ZNF773 ZNF486 ZNF296 ZNF781 ZNF197 ZNF432 ZNF214 ZNF275 ZNF541 ZFX ZNF461	3.32e-07	718	58	13	28
GeneFamily	Zinc fingers CXXC-type	KDM2B KMT2A	6.54e-04	12	58	2	136
GeneFamily	GATA zinc finger domain containing\|Myb/SANT domain containing	BDP1 MIDEAS ZNF541	6.55e-04	53	58	3	532
GeneFamily	Ubiquitin specific peptidases	USP10 USP22 USP16	7.70e-04	56	58	3	366
GeneFamily	Helix-turn-helix CENPB type domain containing	JRK TIGD4	7.71e-04	13	58	2	533
GeneFamily	Dyneins, axonemal	DNAH12 DNAH7	1.33e-03	17	58	2	536
Disease	Neurodevelopmental Disorders	WDR45 ANK2 DSCAM KMT2A	1.34e-04	93	82	4	C1535926
Disease	alpha angle measurement	TNFAIP8 TIAM2	4.13e-04	11	82	2	EFO_0020071
Disease	factor VII activating protease measurement	USP10 ZNF197 DCLRE1A	4.89e-04	55	82	3	EFO_0009368
Disease	aggressive behavior	HIPK3 PLEK	2.20e-03	25	82	2	EFO_0003015
Disease	testosterone measurement	TTBK1 SPEM3 POLR1A ANK2 DSCAM ZNF275 GREB1 MIDEAS HERC4 JHY	2.78e-03	1275	82	10	EFO_0004908
Disease	obsolete_red blood cell distribution width	SP3 POLR1A CFAP97D1 TIGD4 KDM2B BCCIP PLEK HSD11B1L MIDEAS EPG5	4.11e-03	1347	82	10	EFO_0005192

Protein segments in the cluster

Peptide	Gene	Start	Entry
QGHQSFLLKTGPCKK	LINC00158	66	P58513
CPAKHGFQTPRVKKL	EPG5	201	Q9HCE0
PGHQKRILCSIQGFK	EPHA1	961	P21709
HKNKCQAIRPELKEG	BDP1	496	A6H8Y1
HCKKLSLELGGKNPA	ALDH8A1	246	Q9H2A2
KHPCEKNIALYLGKQ	CATSPERD	56	Q86XM0
LTQKRCNKHAYGRKP	CD5L	186	O43866
LQKVVGNCRKLGAPK	HSD11B1L	66	Q7Z5J1
KKFQGIKHECQANGP	DSTN	126	P60981
LGLRKKHIGPSCKVF	ETNPPL	11	Q8TBG4
GLPQKQHFCGRRKKY	ADAMTS16	241	Q8TE57
LNGFTPLHIACKKNR	ANK2	396	Q01484
VLQKPFICHRKTKGG	FKBP14	31	Q9NWM8
QCGHKKLQGRLQLFG	ARHGAP45	746	Q92619
PAKLKIRKQCKHQNG	JHY	361	Q6NUN7
KICKAKPVIFKGHGN	GREB1	376	Q4ZG55
KELAGAHRTNKPCGK	BCCIP	201	Q9P287
GKCSGPRAFKGIQHL	JRK	236	O75564
DHKPKLCRLAKGENG	PDZK1P1	256	A8MUH7
KCFLQHINPKTKGKG	FAM205A	1216	Q6ZU69
HKVCGGKVLLLFQPN	HERC4	921	Q5GLZ8
RVQPHLKKCFEGIAK	DNAH12	1016	Q6ZR08
LNFKPCGLFGKELHK	OSBPL1A	741	Q9BXW6
LHFLEGPQRCGLKRK	HIPK3	116	Q9H422
CRHKKDTFLGPVLKQ	NOC2L	321	Q9Y3T9
FCVKPNKLRNGHKGL	GRB7	301	Q14451
RCKIKAPGFAHLAGL	NDUFS2	421	O75306
LGKAKRKACPLQPDH	PCLAF	91	Q15004
KIHNPQKALECYRKG	IFT172	821	Q9UG01
QHKGNKILCAAKFIP	OBSCN	6486	Q5VST9
KCNHAGKTGKQKRGP	KDM2B	721	Q8NHM5
RVQPHLKKCFEGIAK	DNAH7	1091	Q8WXX0
IKNCQPRKLHFYKNG	IL23R	56	Q5VWK5
LCQKIANAHRGPAKV	CFAP97D1	81	B2RV13
RKLKHPNIITFKGVC	MAP3K12	166	Q12852
QFIGKICDQLKGHLK	GPD1	96	P21695
QPKAQNKRKRCLFGG	MIDEAS	6	Q6PJG2
KDGALDVKRQHKCPG	IRAG2	26	Q12912
TNCLDKPKFGGRNIK	KMT2A	1171	Q03164
CGFFKKRHGPLLKDQ	DCLRE1A	341	Q6PJP8
QINFKGLQSHLKKCG	DCLRE1A	936	Q6PJP8
MPGLIKCGHFLQKQN	CCDC168	566	Q8NDH2
ACGKARVLAKNPKGK	CUL4B	786	Q13620
LQKAKKQRGNKVPCH	COL6A6	526	A6NMZ7
KQCHQKNPVPKRGLA	KRBA2	236	Q6ZNG9
NGSVPGHKNCLVKVK	MRPL3	286	P09001
KAPKKHLQNGIIRGY	DSCAM	1006	O60469
KKQPKGYGLRCHRAI	MRPS5	306	P82675
HNNNKSKRPKGPCLV	SPDYA	51	Q5MJ70
KPQGTKIVCRHVKNG	POLR1A	531	O95602
NVTFRCGQKILHKKG	MMP23B	316	O75900
KHKVKFGNAVQPICL	OVCH1	146	Q7RTY7
IKQGCLLKQGHRRKN	PLEK	246	P08567
HPDGTKCLLGRQKRF	NUDT12	331	Q9BQG2
KQLLVFPGHKCGSLQ	WDR45	156	Q9Y484
GQRNAQKCPKCKIHI	RNF217	416	Q8TC41
GNFKPHLQKLCDGIN	TNFAIP8	176	O95379
IHKKQGAGFLGCVRL	SMURF1	86	Q9HCE7
HKKQGAGFLGCVRLL	SMURF2	86	Q9HAU4
KNGHLSCKAKVQPPR	TRMO	91	Q9BU70
RHCKGDDNGKKANNP	USP22	276	Q9UPT9
GKCFILKKSLIGHQR	ZNF197	796	O14709
LKKLQGKDHVCRFIG	TTBK1	81	Q5TCY1
GKYGHKNLQLRKGCK	ZNF138	41	P52744
QCNGPKANIKGERKH	USP16	661	Q9Y5T5
AFIKIPGCRKQGLVH	ZCCHC17	31	Q9NP64
KLVRGHFCPIKRKAN	TIAM2	1626	Q8IVF5
KNPGLIQDCGGHKVK	SPEM3	916	A0A1B0GUW6
YKGRQLQGCPGAKKH	SMOC2	296	Q9H3U7
GKKKQHICHIPGCGK	SP3	616	Q02447
LKGATKRLCLKHFNG	SUSD4	91	Q5VX71
AHGCFLNAKRNKKPV	PRAMEF5	121	Q5TYX0
LVIGKKRTPHCFKGL	TIGD4	231	Q8IY51
QKQHCGEKPLKRQEG	ZNF773	116	Q6PK81
CKKGFRRPSEKNQHI	ZFX	781	P17010
CGKGFPRKSNLIVHQ	ZNF432	406	O94892
LLSPGVKNKNFKCHR	USP10	716	Q14694
CGKRFKKNAGLSQHL	ZNF275	186	Q9NSD4
GNPLHLCKERFKKIQ	UBR2	1711	Q8IWV8
KVILRKFEKCGHGNL	ZNF486	106	Q96H40
QICGKPFRKRAHLTQ	ZNF781	36	Q8N8C0
LHIGEKPFKCNQCGK	ZNF214	351	Q9UL59
QRIHSGKKPYQCGKA	ZNF461	516	Q8TAF7
GKKPYQCGKAFNHRL	ZNF461	521	Q8TAF7
GCPKSKGNNVFVVHK	ZNF541	421	Q9H0D2
DHKKLGCQLFRGPSR	ZNF296	131	Q8WUU4
HQGAGFQDIPKRCLK	TSN	46	Q15631