Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionG protein-coupled receptor activity

OR2M4 TAAR9 OR51F2 TAS2R16 OR8D1 OR8D2 OR51V1

7.76e-05884257GO:0004930
GeneOntologyMolecularFunctiontransmembrane signaling receptor activity

OR2M4 TAAR9 OR51F2 TAS2R16 OR8D1 RET OR8D2 OR51V1

1.66e-041353258GO:0004888
GeneOntologyMolecularFunctionolfactory receptor activity

OR2M4 OR51F2 OR8D1 OR8D2 OR51V1

1.70e-04431255GO:0004984
GeneOntologyBiologicalProcessdetection of chemical stimulus involved in sensory perception

OR2M4 OR51F2 TAS2R16 OR8D1 OR8D2 OR51V1

2.53e-05485266GO:0050907
GeneOntologyBiologicalProcessdetection of chemical stimulus

OR2M4 OR51F2 TAS2R16 OR8D1 OR8D2 OR51V1

3.90e-05524266GO:0009593
GeneOntologyBiologicalProcesssensory perception of chemical stimulus

OR2M4 OR51F2 TAS2R16 OR8D1 OR8D2 OR51V1

4.96e-05547266GO:0007606
GeneOntologyBiologicalProcessdetection of stimulus involved in sensory perception

OR2M4 OR51F2 TAS2R16 OR8D1 OR8D2 OR51V1

6.99e-05582266GO:0050906
GeneOntologyBiologicalProcessdetection of chemical stimulus involved in sensory perception of smell

OR2M4 OR51F2 OR8D1 OR8D2 OR51V1

1.80e-04432265GO:0050911
GeneOntologyBiologicalProcessdetection of stimulus

OR2M4 OR51F2 TAS2R16 OR8D1 OR8D2 OR51V1

2.28e-04722266GO:0051606
GeneOntologyBiologicalProcesssensory perception of smell

OR2M4 OR51F2 OR8D1 OR8D2 OR51V1

2.53e-04465265GO:0007608
GeneOntologyBiologicalProcesssensory perception

USP53 OR2M4 OR51F2 TAS2R16 OR8D1 OR8D2 OR51V1

2.76e-041072267GO:0007600
MousePhenofused outer hair cell stereocilia

USP53 SYNJ2

3.43e-058162MP:0004528
DomainOlfact_rcpt

OR2M4 OR51F2 OR8D1 OR8D2 OR51V1

1.84e-04393265IPR000725
DomainGPCR_Rhodpsn_7TM

OR2M4 TAAR9 OR51F2 OR8D1 OR8D2 OR51V1

2.59e-04670266IPR017452
Domain7tm_1

OR2M4 TAAR9 OR51F2 OR8D1 OR8D2 OR51V1

2.74e-04677266PF00001
DomainG_PROTEIN_RECEP_F1_1

OR2M4 TAAR9 OR51F2 OR8D1 OR8D2 OR51V1

2.92e-04685266PS00237
DomainG_PROTEIN_RECEP_F1_2

OR2M4 TAAR9 OR51F2 OR8D1 OR8D2 OR51V1

3.06e-04691266PS50262
DomainGPCR_Rhodpsn

OR2M4 TAAR9 OR51F2 OR8D1 OR8D2 OR51V1

3.09e-04692266IPR000276
Domain7TM_GPCR_Srsx

OR2M4 TAAR9 OR8D1

4.94e-04112263SM01381
DomainZF_RING_1

PEX2 PCGF6 MYCBP2 TRIM5

6.58e-04291264PS00518
DomainZF_RING_2

PEX2 PCGF6 MYCBP2 TRIM5

7.20e-04298264PS50089
DomainRING

PEX2 PCGF6 MYCBP2 TRIM5

7.85e-04305264SM00184
DomainZnf_RING

PEX2 PCGF6 MYCBP2 TRIM5

1.01e-03326264IPR001841
DomainZnf_RING_CS

PEX2 PCGF6 TRIM5

1.46e-03163263IPR017907
DomainZnf_C3HC4_RING-type

PEX2 PCGF6 TRIM5

1.71e-03172263IPR018957
Domain-

PEX2 PCGF6 MYCBP2 TRIM5

3.24e-034492643.30.40.10
DomainZnf_RING/FYVE/PHD

PEX2 PCGF6 MYCBP2 TRIM5

3.50e-03459264IPR013083
Domainzf-C3HC4

PEX2 PCGF6 TRIM5

3.57e-03223263PF00097
DomainUSP_1

USP53 USP24

4.25e-0370262PS00972
DomainUCH

USP53 USP24

4.37e-0371262PF00443
DomainUSP_2

USP53 USP24

4.37e-0371262PS00973
DomainUSP_dom

USP53 USP24

4.49e-0372262IPR028889
DomainPeptidase_C19_UCH

USP53 USP24

4.49e-0372262IPR001394
DomainUSP_3

USP53 USP24

4.49e-0372262PS50235
DomainZF_BBOX

MYCBP2 TRIM5

5.51e-0380262PS50119
DomainZnf_B-box

MYCBP2 TRIM5

5.64e-0381262IPR000315
DomainZINC_FINGER_C2H2_2

ZNF611 ZNF740 CHAMP1 ZNF280C

2.13e-02775264PS50157
DomainZINC_FINGER_C2H2_1

ZNF611 ZNF740 CHAMP1 ZNF280C

2.14e-02777264PS00028
DomainZnf_C2H2-like

ZNF611 ZNF740 CHAMP1 ZNF280C

2.32e-02796264IPR015880
DomainZnf_C2H2

ZNF611 ZNF740 CHAMP1 ZNF280C

2.41e-02805264IPR007087
DomainZnF_C2H2

ZNF611 ZNF740 CHAMP1 ZNF280C

2.43e-02808264SM00355
PathwayKEGG_OLFACTORY_TRANSDUCTION

OR2M4 OR51F2 OR8D1 OR8D2 OR51V1

2.20e-04389215M14091
PathwayREACTOME_SENSORY_PERCEPTION

OR2M4 OR51F2 TAS2R16 OR8D1 OR8D2 OR51V1

2.50e-04636216M41834
PathwayREACTOME_OLFACTORY_SIGNALING_PATHWAY

OR2M4 OR51F2 OR8D1 OR8D2 OR51V1

3.04e-04417215M4072
PathwayREACTOME_TRANSCRIPTIONAL_REGULATION_BY_E2F6

PCGF6 L3MBTL2

6.21e-0425212MM15546
PathwayKEGG_MEDICUS_REFERENCE_ACTIVATION_OF_PRC2.2_BY_UBIQUITINATION_OF_H2AK119_IN_GERMLINE_GENES

PCGF6 L3MBTL2

7.25e-0427212M47941
PathwayREACTOME_TRANSCRIPTIONAL_REGULATION_BY_E2F6

PCGF6 L3MBTL2

1.15e-0334212M27826
Pubmed

Activity-dependent neuroprotective protein recruits HP1 and CHD4 to control lineage-specifying genes.

PCGF6 L3MBTL2 CHAMP1 ZNF280C

2.72e-077426429795351
Pubmed

The deubiquitinating protein USP24 interacts with DDB2 and regulates DDB2 stability.

USP53 USP24

1.61e-06326223159851
Pubmed

Mutations of the Transcriptional Corepressor ZMYM2 Cause Syndromic Urinary Tract Malformations.

PCGF6 L3MBTL2 CHAMP1 ZNF280C

2.24e-0612526432891193
Pubmed

L3MBTL2 protein acts in concert with PcG protein-mediated monoubiquitination of H2A to establish a repressive chromatin structure.

PCGF6 L3MBTL2

1.93e-05926221596310
Pubmed

A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells.

PCGF6 L3MBTL2

2.41e-051026212004135
Pubmed

Characterization of a cluster comprising approximately 100 odorant receptor genes in mouse.

OR8D1 OR8D2

2.41e-051026211130974
Pubmed

A High-Density Map for Navigating the Human Polycomb Complexome.

PCGF6 L3MBTL2 CHAMP1 MYCBP2 ZNF280C

2.94e-0549526527705803
Pubmed

PCGF6 controls neuroectoderm specification of human pluripotent stem cells by activating SOX2 expression.

PCGF6 L3MBTL2

2.94e-051126235933409
Pubmed

USP53 plays an antitumor role in hepatocellular carcinoma through deubiquitination of cytochrome c.

USP53 PCGF6 CHAMP1

4.17e-059026335654790
Pubmed

The human olfactory receptor gene family.

OR2M4 OR51F2 OR8D1 OR8D2 OR51V1

4.49e-0554126514983052
Pubmed

New GPCRs from a human lingual cDNA library.

OR8D1 OR8D2

7.26e-051726211705801
Pubmed

Interaction proteomics analysis of polycomb proteins defines distinct PRC1 complexes in mammalian cells.

PCGF6 CHAMP1 MYCBP2

8.89e-0511626321282530
Pubmed

Different evolutionary processes shaped the mouse and human olfactory receptor gene families.

OR51F2 OR8D1 OR8D2 OR51V1

1.13e-0434026411875048
Pubmed

The olfactory receptor gene superfamily of the mouse.

OR51F2 OR8D1 OR8D2 OR51V1

1.13e-0434026411802173
Pubmed

A unified nomenclature for vertebrate olfactory receptors.

OR51F2 OR8D1 OR8D2 OR51V1

1.17e-0434326432295537
Pubmed

Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.

OR51F2 OR8D1 OR8D2 OR51V1

1.21e-0434626414611657
Pubmed

Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases.

USP53 USP24

1.35e-042326214715245
Pubmed

Specific repertoire of olfactory receptor genes in the male germ cells of several mammalian species.

OR2M4 OR8D1

1.47e-04242629119360
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

L3MBTL2 CHAMP1 MYCBP2 USP24

2.49e-0441826434709266
Pubmed

An Oct4-centered protein interaction network in embryonic stem cells.

PCGF6 L3MBTL2 CHAMP1

2.61e-0416726320362541
Pubmed

FBXO42 facilitates Notch signaling activation and global chromatin relaxation by promoting K63-linked polyubiquitination of RBPJ.

PCGF6 L3MBTL2 CHAMP1

3.41e-0418326336129980
Pubmed

PCGF homologs, CBX proteins, and RYBP define functionally distinct PRC1 family complexes.

PCGF6 L3MBTL2

4.33e-044126222325352
Pubmed

Merkel cell polyomavirus recruits MYCL to the EP400 complex to promote oncogenesis.

PCGF6 L3MBTL2

4.54e-044226229028833
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

USP53 CHAMP1 SYNJ2 ZNF280C

6.07e-0452926414621295
Pubmed

The polycomb group protein L3mbtl2 assembles an atypical PRC1-family complex that is essential in pluripotent stem cells and early development.

PCGF6 L3MBTL2

6.70e-045126222770845
InteractionCHAMP1 interactions

USP53 PCGF6 L3MBTL2 CHAMP1

2.22e-05148234int:CHAMP1
InteractionPCGF6 interactions

USP53 PCGF6 L3MBTL2 CHAMP1

3.91e-05171234int:PCGF6
Cytoband11q24.2

OR8D1 OR8D2

5.90e-046326211q24.2
CytobandEnsembl 112 genes in cytogenetic band chr11p15

OR51F2 OR51V1 TRIM5

3.89e-03564263chr11p15
CytobandEnsembl 112 genes in cytogenetic band chr11q24

OR8D1 OR8D2

5.24e-03191262chr11q24
Cytoband11p15.4

OR51F2 OR51V1

5.73e-0320026211p15.4
CytobandEnsembl 112 genes in cytogenetic band chr22q13

TRMU L3MBTL2

1.49e-02330262chr22q13
GeneFamilyOlfactory receptors, family 51

OR51F2 OR51V1

1.30e-0344222164
GeneFamilyOlfactory receptors, family 8

OR8D1 OR8D2

1.61e-0349222155
GeneFamilyUbiquitin specific peptidases

USP53 USP24

2.09e-0356222366
GeneFamilyRing finger proteins

PEX2 PCGF6 TRIM5

4.33e-0327522358
Diseaseobsolete_red blood cell distribution width

ZNF611 OR2M4 TRMU L3MBTL2 OR51V1 TRIM5

4.62e-041347236EFO_0005192
DiseaseThromboembolism

OR51V1 TRIM5

5.39e-0444232HP_0001907
DiseaseLung diseases

RET DNAH11

1.68e-0378232C0024115
Diseaseantihyperlipidemic drug use measurement

TRMU DNAH11

3.61e-03115232EFO_0803367

Protein segments in the cluster

PeptideGeneStartEntry
EFKSILFSLCYFHAC

DNAH11

4076

Q96DT5
LSFCKSHIINHYFCD

OR8D1

166

Q8WZ84
LSFCRSHTVSHYFCD

OR8D2

166

Q9GZM6
THLFSKCFFYTCLCW

IRF1-AS1

86

Q8N8D9
CNKHIKFSCFFHYAV

TRMU

101

O75648
CYHASSHAIFPATFC

L3MBTL2

476

Q969R5
FSYCSSLEIHHFFCD

OR2M4

166

Q96R27
SFCSSMVLSHSYCYH

OR51F2

181

Q8NH61
CLKFFNYCHFHILSH

OR51V1

171

Q9H2C8
HIFCYFCAKSSFLFD

PEX2

261

P28328
YASFCCNHTKAHLFS

LRRC8E

296

Q6NSJ5
LFHCHKCFFTSKMYS

CHAMP1

61

Q96JM3
YSHSCCISQHCDFFI

DPP8

571

Q6V1X1
LHTFCKSCIVRHFYY

PCGF6

151

Q9BYE7
VFYCIKVSSFTHHIF

TAS2R16

101

Q9NYV7
KFHTCFDTSFCFASL

TAAR9

106

Q96RI9
RFQFHSTSFCFICSH

SYNJ2

671

O15056
ECHNTFTACFHSFYP

MYCBP2

1541

O75592
SAKDYFFKAALCHFC

NAPA

201

P54920
CYTSQHYCAFAFHTK

USP53

296

Q70EK8
NHGFLIYKFSHCSFS

TRIM5

456

Q9C035
LLSAFCIHCYHKFAH

RET

651

P07949
YCCFCNEHFSFTMLH

USP24

2421

Q9UPU5
CFCQSIHFLKYFSVH

WDR93

456

Q6P2C0
CSKTFSHRSYLVCHH

ZNF611

571

Q8N823
FASHFSIYIHCSFCK

ZNF280C

631

Q8ND82
FVCEHCFGAFRSSYH

ZNF740

101

Q8NDX6