Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	testosterone 6-beta-hydroxylase activity	CYP3A7 CYP3A4	1.61e-04	5	81	2	GO:0050649
GeneOntologyMolecularFunction	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity	HS3ST5 HS3ST4	3.37e-04	7	81	2	GO:0008467
GeneOntologyMolecularFunction	estrogen 2-hydroxylase activity	CYP3A7 CYP3A4	4.48e-04	8	81	2	GO:0101021
GeneOntologyMolecularFunction	ATP-dependent chromatin remodeler activity	CHD1 CHD2 CHD3	4.52e-04	37	81	3	GO:0140658
Domain	DUF4208	CHD1 CHD2	5.56e-05	3	81	2	PF13907
Domain	DUF4208	CHD1 CHD2	5.56e-05	3	81	2	SM01176
Domain	DUF4208	CHD1 CHD2	5.56e-05	3	81	2	IPR025260
Domain	Chromodomain_CS	CHD1 CHD2 CHD3	6.12e-05	18	81	3	IPR023779
Domain	AbLIM_anchor	ABLIM2 ABLIM3	1.11e-04	4	81	2	PF16182
Domain	AbLIM_anchor	ABLIM2 ABLIM3	1.11e-04	4	81	2	IPR032402
Domain	Chromo_domain	CHD1 CHD2 CHD3	1.49e-04	24	81	3	IPR023780
Domain	Cyt_P450_E_grp-II	CYP3A7 CYP3A4	1.84e-04	5	81	2	IPR002402
Domain	Chromo	CHD1 CHD2 CHD3	1.90e-04	26	81	3	PF00385
Domain	CHROMO_1	CHD1 CHD2 CHD3	2.38e-04	28	81	3	PS00598
Domain	CHROMO_2	CHD1 CHD2 CHD3	2.38e-04	28	81	3	PS50013
Domain	Cyt_P450_E_CYP3A	CYP3A7 CYP3A4	2.76e-04	6	81	2	IPR008072
Domain	SNF2_N	CHD1 CHD2 CHD3	3.56e-04	32	81	3	IPR000330
Domain	Chromodomain-like	CHD1 CHD2 CHD3	3.56e-04	32	81	3	IPR016197
Domain	SNF2_N	CHD1 CHD2 CHD3	3.56e-04	32	81	3	PF00176
Domain	Chromo/shadow_dom	CHD1 CHD2 CHD3	3.90e-04	33	81	3	IPR000953
Domain	CHROMO	CHD1 CHD2 CHD3	3.90e-04	33	81	3	SM00298
Domain	DNA/RNA_helicase_DEAH_CS	CHD1 CHD2 CHD3	4.65e-04	35	81	3	IPR002464
Domain	HP	ABLIM2 ABLIM3	5.11e-04	8	81	2	PS51089
Domain	-	ABLIM2 ABLIM3	5.11e-04	8	81	2	1.10.950.10
Domain	VHP	ABLIM2 ABLIM3	5.11e-04	8	81	2	PF02209
Domain	Villin_headpiece	ABLIM2 ABLIM3	5.11e-04	8	81	2	IPR003128
Domain	VHP	ABLIM2 ABLIM3	5.11e-04	8	81	2	SM00153
Domain	DEAH_ATP_HELICASE	CHD1 CHD2 CHD3	5.94e-04	38	81	3	PS00690
Domain	PLAC	THSD4 ADAMTS6	1.63e-03	14	81	2	PF08686
Domain	APOBEC/CMP_deaminase_Zn-bd	DCTD APOBEC3F	1.63e-03	14	81	2	IPR016192
Domain	CYT_DCMP_DEAMINASES_2	DCTD APOBEC3F	1.88e-03	15	81	2	PS51747
Domain	Homeobox_KN	TGIF2LY TGIF2LX	2.42e-03	17	81	2	PF05920
Domain	Cytidine_deaminase-like	DCTD APOBEC3F	2.42e-03	17	81	2	IPR016193
Domain	Homeobox_KN_domain	TGIF2LY TGIF2LX	2.42e-03	17	81	2	IPR008422
Domain	CYT_DCMP_DEAMINASES_1	DCTD APOBEC3F	2.42e-03	17	81	2	PS00903
Domain	CMP_dCMP_Zn-bd	DCTD APOBEC3F	2.42e-03	17	81	2	IPR002125
Domain	PLAC	THSD4 ADAMTS6	3.03e-03	19	81	2	PS50900
Domain	PLAC	THSD4 ADAMTS6	3.03e-03	19	81	2	IPR010909
Domain	Homeodomain-like	CERS2 TGIF2LY SSH1 TGIF2LX MIER1 CRX	3.20e-03	332	81	6	IPR009057
Domain	Tyr_Pase_AS	PTPN11 SSH1 PTPRO	3.93e-03	73	81	3	IPR016130
Domain	ADAM_spacer1	THSD4 ADAMTS6	4.43e-03	23	81	2	IPR010294
Domain	ADAM_spacer1	THSD4 ADAMTS6	4.43e-03	23	81	2	PF05986
Domain	Ricin_B_lectin	GALNT14 GALNT11	5.22e-03	25	81	2	PF00652
Pubmed	Characterization of the CHD family of proteins.	CHD1 CHD2 CHD3	5.23e-08	4	83	3	9326634
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	BBX RNF2 IPO7 BAZ2A PSMA6 CHD1 CHD2 CHD3 PRDM15 MIER1 DNMT3A	2.20e-07	608	83	11	36089195
Pubmed	Novel Mechanism of Foxo1 Phosphorylation in Glucagon Signaling in Control of Glucose Homeostasis.	FOXO1 LEPR	5.63e-06	2	83	2	30201683
Pubmed	Digging Deeper into CYP3A Testosterone Metabolism: Kinetic, Regioselectivity, and Stereoselectivity Differences between CYP3A4/5 and CYP3A7.	CYP3A7 CYP3A4	5.63e-06	2	83	2	28986474
Pubmed	Rapid development of myeloproliferative neoplasm in mice with Ptpn11D61Y mutation and haploinsufficient for Dnmt3a.	PTPN11 DNMT3A	5.63e-06	2	83	2	29464054
Pubmed	Expression of a novel TGIF subclass homeobox gene, Tex1, in the spermatids of mouse testis during spermatogenesis.	TGIF2LY TGIF2LX	5.63e-06	2	83	2	11960710
Pubmed	Leukaemogenic effects of Ptpn11 activating mutations in the stem cell microenvironment.	PTPN11 LEPR	5.63e-06	2	83	2	27783593
Pubmed	Dynamics of Cytosine Methylation in the Proximal Promoters of CYP3A4 and CYP3A7 in Pediatric and Prenatal Livers.	CYP3A7 CYP3A4	5.63e-06	2	83	2	26772622
Pubmed	Ablation of the N-type calcium channel ameliorates diabetic nephropathy with improved glycemic control and reduced blood pressure.	CACNA1B LEPR	5.63e-06	2	83	2	27273361
Pubmed	FoxO6 integrates insulin signaling with gluconeogenesis in the liver.	FOXO6 LEPR	5.63e-06	2	83	2	21940782
Pubmed	A model of activation of the protein tyrosine phosphatase SHP-2 by the human leptin receptor.	PTPN11 LEPR	5.63e-06	2	83	2	11342028
Pubmed	Aberrant Forkhead box O1 function is associated with impaired hepatic metabolism.	FOXO1 LEPR	5.63e-06	2	83	2	16997836
Pubmed	Leptin receptor activation of SH2 domain containing protein tyrosine phosphatase 2 modulates Ob receptor signal transduction.	PTPN11 LEPR	5.63e-06	2	83	2	10449753
Pubmed	Expression of CYP3A4 and CYP3A7 in Human Foetal Tissues and its Correlation with Nuclear Receptors.	CYP3A7 CYP3A4	5.63e-06	2	83	2	25689036
Pubmed	Immunohistochemical markers of CYP3A4 and CYP3A7: a new tool towards personalized pharmacotherapy of hepatocellular carcinoma.	CYP3A7 CYP3A4	5.63e-06	2	83	2	27349315
Pubmed	An insulin-independent mechanism for transcriptional regulation of Foxo1 in type 2 diabetic mice.	FOXO1 LEPR	5.63e-06	2	83	2	34058194
Pubmed	CHD1 and CHD2 are positive regulators of HIV-1 gene expression.	CHD1 CHD2	5.63e-06	2	83	2	25297984
Pubmed	Association of TGIFLX/Y mRNA expression with prostate cancer.	TGIF2LY TGIF2LX	5.63e-06	2	83	2	18663611
Pubmed	Dual-specificity tyrosine phosphorylation-regulated kinase 1A ameliorates insulin resistance in neurons by up-regulating IRS-1 expression.	DYRK1A LEPR	5.63e-06	2	83	2	31723029
Pubmed	Differential regulation of CYP3A4 and CYP3A7 by dimethylsulfoxide in primary human hepatocytes.	CYP3A7 CYP3A4	5.63e-06	2	83	2	15379787
Pubmed	The human-specific Yp11.2/Xq21.3 homology block encodes a potentially functional testis-specific TGIF-like retroposon.	TGIF2LY TGIF2LX	5.63e-06	2	83	2	12226713
Pubmed	Association of TGIFLX/Y mRNA expression with azoospermia in infertile men.	TGIF2LY TGIF2LX	5.63e-06	2	83	2	18384077
Pubmed	FoxO1 as a double-edged sword in the pancreas: analysis of pancreas- and β-cell-specific FoxO1 knockout mice.	FOXO1 LEPR	5.63e-06	2	83	2	22215655
Pubmed	Role of Chromatin Structural Changes in Regulating Human CYP3A Ontogeny.	CYP3A7 CYP3A4	5.63e-06	2	83	2	26921389
Pubmed	Molecular mechanisms of polymorphic CYP3A7 expression in adult human liver and intestine.	CYP3A7 CYP3A4	5.63e-06	2	83	2	11940601
Pubmed	The kinase DYRK1A phosphorylates the transcription factor FKHR at Ser329 in vitro, a novel in vivo phosphorylation site.	FOXO1 DYRK1A	5.63e-06	2	83	2	11311120
Pubmed	Red Pepper (Capsicum annuum L.) Seed Extract Improves Glycemic Control by Inhibiting Hepatic Gluconeogenesis via Phosphorylation of FOXO1 and AMPK in Obese Diabetic db/db Mice.	FOXO1 LEPR	5.63e-06	2	83	2	32842462
Pubmed	Developmental regulation of CYP3A4 and CYP3A7 in Chinese Han population.	CYP3A7 CYP3A4	5.63e-06	2	83	2	27727071
Pubmed	Expression and cyclic variability of CYP3A4 and CYP3A7 isoforms in human endometrium and cervix during the menstrual cycle.	CYP3A7 CYP3A4	5.63e-06	2	83	2	12485945
Pubmed	FOXO1 mediates the autocrine effect of endothelin-1 on endothelial cell survival.	FOXO1 LEPR	1.69e-05	3	83	2	22570335
Pubmed	Micro-RNA-27a/b negatively regulates hepatic gluconeogenesis by targeting FOXO1.	FOXO1 LEPR	1.69e-05	3	83	2	31526292
Pubmed	FoxO6, a novel member of the FoxO class of transcription factors with distinct shuttling dynamics.	FOXO1 FOXO6	1.69e-05	3	83	2	12857750
Pubmed	MiR-181c restrains nitration stress of endothelial cells in diabetic db/db mice through inhibiting the expression of FoxO1.	FOXO1 LEPR	1.69e-05	3	83	2	28223216
Pubmed	FoxO6 integrates insulin signaling with MTP for regulating VLDL production in the liver.	FOXO6 LEPR	1.69e-05	3	83	2	24437489
Pubmed	Cdc25A regulates matrix metalloprotease 1 through Foxo1 and mediates metastasis of breast cancer cells.	FOXO1 MMP1	1.69e-05	3	83	2	21670150
Pubmed	The P450 oxidoreductase genotype is associated with CYP3A activity in vivo as measured by the midazolam phenotyping test.	CYP3A7 CYP3A4	1.69e-05	3	83	2	19801957
Pubmed	Cytochrome P450 3A gene variation, steroid hormone serum levels and prostate cancer--The Rotterdam Study.	CYP3A7 CYP3A4	1.69e-05	3	83	2	20621111
Pubmed	Increased expression of DNA methyltransferase 3a in obese adipose tissue: studies with transgenic mice.	LEPR DNMT3A	1.69e-05	3	83	2	19680236
Pubmed	DYRK1A regulates B cell acute lymphoblastic leukemia through phosphorylation of FOXO1 and STAT3.	FOXO1 DYRK1A	1.69e-05	3	83	2	33393494
Pubmed	FOXO1 inhibition synergizes with FGF21 to normalize glucose control in diabetic mice.	FOXO1 LEPR	1.69e-05	3	83	2	33577983
Pubmed	FoxO1 regulates leptin-induced mood behavior by targeting tyrosine hydroxylase.	FOXO1 LEPR	1.69e-05	3	83	2	30500562
Pubmed	Cytochrome P450 3As gene expression and testosterone 6 beta-hydroxylase activity in human fetal membranes and placenta at full term.	CYP3A7 CYP3A4	1.69e-05	3	83	2	20118548
Pubmed	CHD1 and SPOP synergistically protect prostate epithelial cells from DNA damage.	CHD1 CHD2	1.69e-05	3	83	2	33022763
Pubmed	SOCS3 mediates feedback inhibition of the leptin receptor via Tyr985.	PTPN11 LEPR	1.69e-05	3	83	2	11018044
Pubmed	Rap1A accelerates homocysteine-induced ANA-1 cells inflammation via synergy of FoxO1 and DNMT3a.	FOXO1 DNMT3A	1.69e-05	3	83	2	36791985
Pubmed	Candidate gene study of FOXO1, FOXO4, and FOXO6 reveals no association with human longevity in Germans.	FOXO1 FOXO6	1.69e-05	3	83	2	21388494
Pubmed	Metabolic pathways of inhaled glucocorticoids by the CYP3A enzymes.	CYP3A7 CYP3A4	1.69e-05	3	83	2	23143891
Pubmed	FoxO1 links insulin resistance to proinflammatory cytokine IL-1beta production in macrophages.	FOXO1 LEPR	1.69e-05	3	83	2	19651810
Pubmed	Development of template systems for ligand interactions of CYP3A5 and CYP3A7 and their distinctions from CYP3A4 template.	CYP3A7 CYP3A4	1.69e-05	3	83	2	33866277
Pubmed	Niacin receptor GPR109A inhibits insulin secretion and is down-regulated in type 2 diabetic islet beta-cells.	HCAR3 LEPR	1.69e-05	3	83	2	27570060
Pubmed	Contribution of three CYP3A isoforms to metabolism of R- and S-warfarin.	CYP3A7 CYP3A4	1.69e-05	3	83	2	20615193
Pubmed	Effects of hypoxia-inducible factor-1α chemical stabilizer, CoCl(2) and hypoxia on gene expression of CYP3As in human fetal liver cells.	CYP3A7 CYP3A4	1.69e-05	3	83	2	22277676
Pubmed	Comparison of steroid hormone hydroxylation mediated by cytochrome P450 3A subfamilies.	CYP3A7 CYP3A4	1.69e-05	3	83	2	32001245
Pubmed	Identification of entacapone as a chemical inhibitor of FTO mediating metabolic regulation through FOXO1.	FOXO1 LEPR	1.69e-05	3	83	2	30996080
Pubmed	Glucagon regulates hepatic mitochondrial function and biogenesis through FOXO1.	FOXO1 LEPR	1.69e-05	3	83	2	31026811
Pubmed	CYP3A Polymorphism and Chronic Mercury Intoxication.	CYP3A7 CYP3A4	1.69e-05	3	83	2	32146629
Pubmed	The B55α-containing PP2A holoenzyme dephosphorylates FOXO1 in islet β-cells under oxidative stress.	FOXO1 LEPR	1.69e-05	3	83	2	22417654
Pubmed	Anthocyanin increases adiponectin secretion and protects against diabetes-related endothelial dysfunction.	FOXO1 LEPR	1.69e-05	3	83	2	24595303
Pubmed	Differences in CYP3A41G genotype distribution and haplotypes of CYP3A4, CYP3A5 and CYP3A7 in 3 Chinese populations.	CYP3A7 CYP3A4	1.69e-05	3	83	2	17582393
Pubmed	CYP3A7, CYP3A4, and CYP3A5 genetic polymorphisms in recipients rather than donors influence tacrolimus concentrations in the early stages after liver transplantation.	CYP3A7 CYP3A4	1.69e-05	3	83	2	34688813
Pubmed	Neuronal Shp2 tyrosine phosphatase controls energy balance and metabolism.	PTPN11 LEPR	1.69e-05	3	83	2	15520383
Pubmed	Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.	CACNA1B RASGRF1 GIGYF2 CNKSR2 ABLIM2 ABLIM3 MADD	2.01e-05	347	83	7	17114649
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	WDR19 RNF2 IPO7 ADAMTS6 AXL WBP4 CHD2 PPP2R3C RYR2	2.19e-05	638	83	9	31182584
Pubmed	Catalog of mRNA expression patterns for DNA methylating and demethylating genes in developing mouse lower urinary tract.	CHD2 DNMT3A APOBEC3F	2.56e-05	24	83	3	23920106
Pubmed	Molecular cloning of a mouse scavenger receptor with C-type lectin (SRCL)(1), a novel member of the scavenger receptor family.	TGIF2LY TGIF2LX	3.37e-05	4	83	2	11718900
Pubmed	Central injection of fibroblast growth factor 1 induces sustained remission of diabetic hyperglycemia in rodents.	FOXO1 LEPR	3.37e-05	4	83	2	27213816
Pubmed	Metabolic inflexibility impairs insulin secretion and results in MODY-like diabetes in triple FoxO-deficient mice.	FOXO1 LEPR	3.37e-05	4	83	2	25264246
Pubmed	Novel repressor regulates insulin sensitivity through interaction with Foxo1.	FOXO1 LEPR	3.37e-05	4	83	2	22510882
Pubmed	FoxO6-mediated IL-1β induces hepatic insulin resistance and age-related inflammation via the TF/PAR2 pathway in aging and diabetic mice.	FOXO6 LEPR	3.37e-05	4	83	2	30974318
Pubmed	Histopathology of melanosis coli and determination of its associated genes by comparative analysis of expression microarrays.	CYP3A7 CYP3A4	3.37e-05	4	83	2	26238215
Pubmed	Hepatic suppression of Foxo1 and Foxo3 causes hypoglycemia and hyperlipidemia in mice.	FOXO1 LEPR	3.37e-05	4	83	2	22147007
Pubmed	Allele and genotype frequencies of CYP3A4, CYP3A5, CYP3A7, and GSTP1 gene polymorphisms among mainland Tibetan, Mongolian, Uyghur, and Han Chinese populations.	CYP3A7 CYP3A4	3.37e-05	4	83	2	34689350
Pubmed	TOX3 deficiency mitigates hyperglycemia by suppressing hepatic gluconeogenesis through FoxO1.	FOXO1 LEPR	3.37e-05	4	83	2	38145825
Pubmed	MiR-135a Promotes Inflammatory Responses of Vascular Smooth Muscle Cells From db/db Mice via Downregulation of FOXO1.	FOXO1 LEPR	3.37e-05	4	83	2	29332916
Pubmed	Metabolic stress-induced activation of FoxO1 triggers diabetic cardiomyopathy in mice.	FOXO1 LEPR	3.37e-05	4	83	2	22326951
Pubmed	Foxo1 integrates insulin signaling with mitochondrial function in the liver.	FOXO1 LEPR	3.37e-05	4	83	2	19838201
Pubmed	TOX4, an insulin receptor-independent regulator of hepatic glucose production, is activated in diabetic liver.	FOXO1 LEPR	3.37e-05	4	83	2	34914893
Pubmed	LASS2 regulates hepatocyte steatosis by interacting with NDUFS2/OXPHOS related proteins.	CERS2 LEPR	3.37e-05	4	83	2	32279995
Pubmed	Spatial and temporal expression of FoxO transcription factors in the developing and adult murine brain.	FOXO1 FOXO6	3.37e-05	4	83	2	16326148
Pubmed	CYP3A7, CYP3A5, CYP3A4, and ABCB1 genetic polymorphisms, cyclosporine concentration, and dose requirement in transplant recipients.	CYP3A7 CYP3A4	3.37e-05	4	83	2	18978522
Pubmed	IRS2 signaling in LepR-b neurons suppresses FoxO1 to control energy balance independently of leptin action.	FOXO1 LEPR	3.37e-05	4	83	2	22560222
Pubmed	Inhibition of vascular endothelial growth factor receptor 2-mediated endothelial cell activation by Axl tyrosine kinase receptor.	PTPN11 AXL	3.37e-05	4	83	2	15507525
Pubmed	The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6→ Tbr2→ Tbr1.	RNF2 BAZ2A CHD2 CHD3 DNMT3A	3.84e-05	157	83	5	30186101
Pubmed	Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry.	PTPN11 DYRK1A CHD1	5.08e-05	30	83	3	12522270
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	CERS2 RPF1 C5orf34 DYRK1A TFIP11 CHD2 CHD3 MMP1 ABLIM3 MIER1 MADD	5.33e-05	1084	83	11	11544199
Pubmed	Genome-wide association study of exercise behavior in Dutch and American adults.	GABRG3 LEPR	5.60e-05	5	83	2	19727025
Pubmed	Cytochrome P450 isoforms are differently up-regulated in aflatoxin B₁-exposed human lymphocytes and monocytes.	CYP3A7 CYP3A4	5.60e-05	5	83	2	24168324
Pubmed	Genomic organization of the human CYP3A locus: identification of a new, inducible CYP3A gene.	CYP3A7 CYP3A4	5.60e-05	5	83	2	11266076
Pubmed	Essential Role for Hypothalamic Calcitonin Receptor‒Expressing Neurons in the Control of Food Intake by Leptin.	CALCR LEPR	5.60e-05	5	83	2	29522093
Pubmed	Hepatic p38α MAPK controls gluconeogenesis via FOXO1 phosphorylation at S273 during glucagon signalling in mice.	FOXO1 LEPR	5.60e-05	5	83	2	37202506
Pubmed	SREBP1c-CRY1 signalling represses hepatic glucose production by promoting FOXO1 degradation during refeeding.	FOXO1 LEPR	5.60e-05	5	83	2	27412556
Pubmed	Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites.	CYP3A7 CYP3A4	5.60e-05	5	83	2	11093772
Pubmed	Human cytochrome P450 3A7 has a distinct high catalytic activity for the 16alpha-hydroxylation of estrone but not 17beta-estradiol.	CYP3A7 CYP3A4	5.60e-05	5	83	2	14559847
Pubmed	Calcitonin Receptor Neurons in the Mouse Nucleus Tractus Solitarius Control Energy Balance via the Non-aversive Suppression of Feeding.	CALCR LEPR	5.60e-05	5	83	2	31955990
Pubmed	Developmental expression pattern of monoamine oxidases in sensory organs and neural crest derivatives.	MAOB LAMA2	5.60e-05	5	83	2	12900932
Pubmed	Calcitonin Receptor Signaling Inhibits Muscle Stem Cells from Escaping the Quiescent State and the Niche.	CALCR LAMA2	5.60e-05	5	83	2	26440893
Pubmed	Expression pattern of TG-interacting factor 2 during mouse development.	TGIF2LY TGIF2LX	5.60e-05	5	83	2	15749073
Pubmed	[Study of the impact of candidate genes on bone mineral density in postmenopausal women].	CALCR LEPR	5.60e-05	5	83	2	16412323
Pubmed	GPR109A as an anti-inflammatory receptor in retinal pigment epithelial cells and its relevance to diabetic retinopathy.	HCAR3 LEPR	5.60e-05	5	83	2	22427566
Pubmed	Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays.	CACNA1B PHKA2 CHD2	5.61e-05	31	83	3	14684825
GeneFamily	Cytochrome P450 family 3	CYP3A7 CYP3A4	3.09e-04	8	61	2	1002
ToppCell	human_hepatoblastoma-Tumor_cells-T8\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	FOXO1 CYP3A7 MAOB ABLIM3 F5 LEPR L3MBTL4	7.29e-08	192	83	7	e785135262f4c9cc66c403bf362bb34643b212c5
ToppCell	Fetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	GABRG3 MAOB LAMA2 CNKSR2 ABLIM3 RYR2	1.70e-06	194	83	6	011e14d9ed1393275f892060e7708ffadcd0767f
ToppCell	Fetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	GABRG3 MAOB LAMA2 CNKSR2 ABLIM3 RYR2	1.70e-06	194	83	6	35f132cc38ac133be01834ed0946188aa0757eb4
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c12-FOXP3\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	NLRP11 ENPP6 CYP3A4 TFIP11 CHD3	1.10e-05	156	83	5	fbe23876f0899853cea3c5c4f3044a9cea064d5b
ToppCell	390C-Lymphocytic-CD4_T-cell-Treg_cell_2\|390C / Donor, Lineage, Cell class and subclass (all cells)	C5orf34 SLC7A6OS TFIP11 CNKSR2 MADD	2.07e-05	178	83	5	829ea00c022a78d1861aa3ec53503272976775d9
ToppCell	Control-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ENPP6 CNKSR2 ABLIM2 ABLIM3 RYR2	2.19e-05	180	83	5	08ae0f5d95c45feba68ad99788f7af7ff4c979af
ToppCell	Control-Stromal_mesenchymal-Matrix_Fibroblast\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ENPP6 CYP3A7 CNKSR2 ABLIM2 ABLIM3	2.19e-05	180	83	5	9b1de1b4711adbf9a423f4d2d08f3f4c78f1f8f4
ToppCell	Control-Stromal_mesenchymal-Matrix_Fibroblast-Diff_MatrixFB\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ENPP6 CYP3A7 CNKSR2 ABLIM2 ABLIM3	2.25e-05	181	83	5	9e7d0f1afb8d9bc5a209ddb5314df3a25a0274d9
ToppCell	390C-Lymphocytic-CD4_T-cell-Treg_cell_2\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	C5orf34 SLC7A6OS TFIP11 CNKSR2 MADD	2.31e-05	182	83	5	21744c9c792e57d5d41b25986f419b2358c7057b
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ENPP6 GALNT14 MGAM ABLIM3 L3MBTL4	2.56e-05	186	83	5	5784d255e9ca449d375d81938d0fbbd8a7eb44f6
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ENPP6 GALNT14 MGAM ABLIM3 L3MBTL4	2.62e-05	187	83	5	dcf6475ece5b34d9d58a0d1f51c18acedb19c119
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ENPP6 GALNT14 MGAM ABLIM3 L3MBTL4	2.62e-05	187	83	5	f1356273bd3587b6883295edf15cb9cdb706c057
ToppCell	Mesenchymal-matrix_fibroblast_1_cell\|World / Lineage, Cell type, age group and donor	MAOB LAMA2 CNKSR2 ABLIM3 RYR2	3.05e-05	193	83	5	acad568621ed677031797b8c2e34dafea798d681
ToppCell	Bronchial-NucSeq-Immune_Myeloid-Macrophage_other-Macro_AW_CX3CR1\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	NLRP11 MGAM C5orf34 CALCR AXL	3.37e-05	197	83	5	0a404b4494a2246d5a92299235056f0fda4d2b48
ToppCell	Bronchial-10x5prime-Epithelial-Epi_airway_neuro-secretory-Neuroendocrine\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	CACNA1B HS3ST5 CNKSR2 F5 RYR2	3.37e-05	197	83	5	3a0e97bfebe82f9687d518baaad7f20d0ffea8a1
ToppCell	primary_auditory_cortex_(A1C)-Neuronal\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CACNA1B GABRG3 SLC44A5 CNKSR2 RYR2	3.45e-05	198	83	5	6d18b45eda4014759e6dd282d78ffd28df8a6044
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CACNA1B GABRG3 SLC44A5 CNKSR2 RYR2	3.45e-05	198	83	5	8ab40fae14fe02e39bc8c8da187a5cd60c787643
ToppCell	Neuronal\|World / cells hierarchy compared to all cells using T-Statistic	CACNA1B GABRG3 CNKSR2 ABLIM2 RYR2	3.62e-05	200	83	5	48d801219bc771d6c7e151dc88ca4c179988de85
Computational	Energy pathways.	CYP3A7 MAOB ACADL CYP3A4 LEPR	1.01e-04	99	51	5	MODULE_43
Drug	formylglutamate	MGAM HAL APOBEC3F	1.56e-06	7	82	3	CID000102672
Drug	dihydrokavain	MAOB CYP3A4 DYRK1A	5.31e-06	10	82	3	CID000098356
Drug	Antipyrine, 4-hydroxy [1672-63-5]; Up 200; 19.6uM; MCF7; HT_HG-U133A	SLC5A5 GABRG3 CALCR RASGRF1 BAZ2A LAMA2 SAYSD1	6.06e-06	192	82	7	4175_UP
Drug	Isoxsuprine hydrochloride [579-56-6]; Up 200; 11.8uM; HL60; HG-U133A	WDR19 MGAM OVGP1 BBX BAZ2A WBP4 CHD3	7.41e-06	198	82	7	1985_UP
Disease	androstenediol (3beta,17beta) disulfate (1) measurement	CYP3A7 CYP3A4 CRX	1.59e-06	9	80	3	EFO_0800278
Disease	X-21470 measurement	CYP3A7 CYP3A4 CRX	6.84e-06	14	80	3	EFO_0800817
Disease	tacrolimus measurement	CYP3A7 CYP3A4	4.34e-05	4	80	2	EFO_0008458
Disease	estrone conjugate measurement	CYP3A7 CYP3A4	4.34e-05	4	80	2	EFO_0007971
Disease	tauro-beta-muricholate measurement	CYP3A7 CYP3A4	7.22e-05	5	80	2	EFO_0800213
Disease	glyco-beta-muricholate measurement	CYP3A7 CYP3A4	7.22e-05	5	80	2	EFO_0800569
Disease	longitudinal BMI measurement	CALCR ADAMTS6 CNKSR2 LEPR	7.46e-05	82	80	4	EFO_0005937
Disease	dehydroisoandrosterone sulfate DHEA-S measurement	CYP3A7 CYP3A4	1.08e-04	6	80	2	EFO_0021119
Disease	androstenediol (3beta,17beta) monosulfate (1) measurement	CYP3A7 CYP3A4	1.08e-04	6	80	2	EFO_0800294
Disease	Neurodevelopmental Disorders	PTPN11 DYRK1A GIGYF2 CHD2	1.22e-04	93	80	4	C1535926
Disease	X-24574 measurement	CYP3A7 CYP3A4	1.51e-04	7	80	2	EFO_0800897
Disease	serum metabolite measurement	ENPP6 GABRG3 CYP3A7 SLC44A5 ACADL RASGRF1 CYP3A4 SLC7A6OS HAL DCTD	2.35e-04	945	80	10	EFO_0005653
Disease	Diabetic Nephropathy	PTPN11 AXL LEPR	2.35e-04	44	80	3	C0011881
Disease	refractive error	GALNT14 RASGRF1 LAMA2 CNKSR2 L3MBTL4 CRX	2.63e-04	326	80	6	MONDO_0004892
Disease	Prostatic Neoplasms	SLC5A5 FOXO1 CYP3A4 BAZ2A WASF3 CHD1 CHD3 GREB1	2.67e-04	616	80	8	C0033578
Disease	Malignant neoplasm of prostate	SLC5A5 FOXO1 CYP3A4 BAZ2A WASF3 CHD1 CHD3 GREB1	2.67e-04	616	80	8	C0376358
Disease	4-androsten-3alpha,17alpha-diol monosulfate (3) measurement	CYP3A7 CYP3A4	3.22e-04	10	80	2	EFO_0022090
Disease	5alpha-androstan-3beta,17alpha-diol disulfate measurement	CYP3A7 CYP3A4	3.22e-04	10	80	2	EFO_0800289
Disease	creatinine measurement	CERS2 RNF2 FOXO6 USP11 PSMA6 LAMA2 GIGYF2 CHD2 SAYSD1 ABLIM3	3.53e-04	995	80	10	EFO_0004518
Disease	DNA repair protein RAD51 homolog 4 measurement	CYP3A7 CYP3A4	3.93e-04	11	80	2	EFO_0801531
Disease	thoracic aortic aneurysm (is_implicated_in)	THSD4 MMP1	3.93e-04	11	80	2	DOID:14004 (is_implicated_in)
Disease	androstenediol (3beta,17beta) monosulfate (2) measurement	CYP3A7 CYP3A4	3.93e-04	11	80	2	EFO_0800295
Disease	5alpha-androstan-3beta,17beta-diol monosulfate (2) measurement	CYP3A7 CYP3A4	4.71e-04	12	80	2	EFO_0800291
Disease	urinary metabolite measurement	CYP3A7 SLC44A5 ACADL CYP3A4 HAL	5.49e-04	245	80	5	EFO_0005116
Disease	COVID-19, coronary artery disease	AXL TAF1A	5.55e-04	13	80	2	EFO_0001645, MONDO_0100096
Disease	androstenediol (3alpha, 17alpha) monosulfate (3) measurement	CYP3A7 CYP3A4	5.55e-04	13	80	2	EFO_0800293
Disease	5alpha-pregnan-3beta,20beta-diol monosulfate (1) measurement	CYP3A7 CYP3A4	5.55e-04	13	80	2	EFO_0800284
Disease	5alpha-androstan-3alpha,17alpha-diol monosulfate measurement	CYP3A7 CYP3A4	6.47e-04	14	80	2	EFO_0800283
Disease	thrombosis (is_implicated_in)	MMP1 F5	7.45e-04	15	80	2	DOID:0060903 (is_implicated_in)
Disease	16a-hydroxy DHEA 3-sulfate measurement	CYP3A7 CYP3A4	7.45e-04	15	80	2	EFO_0800301
Disease	Myopia	RASGRF1 LAMA2	7.45e-04	15	80	2	C0027092
Disease	dehydroepiandrosterone sulphate measurement	CYP3A7 CYP3A4 CRX	8.47e-04	68	80	3	EFO_0007001
Disease	X-21410 measurement	CYP3A7 CYP3A4	8.50e-04	16	80	2	EFO_0800813
Disease	Blood Coagulation Disorders	PTPN11 F5	8.50e-04	16	80	2	C0005779
Disease	andro steroid monosulfate C19H28O6S (1) measurement	CYP3A7 CYP3A4	8.50e-04	16	80	2	EFO_0800305
Disease	5alpha-androstan-3alpha,17beta-diol monosulfate (1) measurement	CYP3A7 CYP3A4	1.08e-03	18	80	2	EFO_0800288
Disease	metabolonic lactone sulfate measurement	CYP3A7 CYP3A4	1.20e-03	19	80	2	EFO_0800659
Disease	unipolar depression, response to bupropion, mood disorder	ENPP6 ADAMTS6	1.20e-03	19	80	2	EFO_0003761, EFO_0004247, EFO_0006326
Disease	Juvenile Myelomonocytic Leukemia	PTPN11 DNMT3A	1.20e-03	19	80	2	C0349639
Disease	etiocholanolone glucuronide measurement	CYP3A7 CYP3A4	1.20e-03	19	80	2	EFO_0800362
Disease	androsterone glucuronide measurement	CYP3A7 CYP3A4	1.34e-03	20	80	2	EFO_0800317
Disease	Autism Spectrum Disorders	CHD2 RYR2 DNMT3A	1.62e-03	85	80	3	C1510586
Disease	X-24947 measurement	CYP3A7 CYP3A4	1.62e-03	22	80	2	EFO_0800910
Disease	5alpha-androstan-3beta,17beta-diol disulfate measurement	CYP3A7 CYP3A4	1.62e-03	22	80	2	EFO_0021115
Disease	age at voice drop	ECPAS LEPR	1.62e-03	22	80	2	EFO_0007888
Disease	free cholesterol measurement, high density lipoprotein cholesterol measurement	CERS2 HCAR3 MYO1H LEPR MADD	1.68e-03	315	80	5	EFO_0004612, EFO_0008591
Disease	total cholesterol measurement, high density lipoprotein cholesterol measurement	CERS2 HCAR3 MYO1H LEPR MADD	1.68e-03	315	80	5	EFO_0004574, EFO_0004612
Disease	phospholipid measurement, high density lipoprotein cholesterol measurement	CERS2 HCAR3 MYO1H LEPR MADD	1.82e-03	321	80	5	EFO_0004612, EFO_0004639
Disease	lipid measurement, high density lipoprotein cholesterol measurement	CERS2 HCAR3 MYO1H LEPR MADD	2.06e-03	330	80	5	EFO_0004529, EFO_0004612
Disease	pallidum volume	HAL HS3ST4	2.09e-03	25	80	2	EFO_0006933
Disease	epiandrosterone sulfate measurement	CYP3A7 CYP3A4	2.09e-03	25	80	2	EFO_0021120
Disease	apolipoprotein A 1 measurement	CERS2 MGAM PTPN11 MYO1H SAYSD1 VPS53 LEPR MADD	2.11e-03	848	80	8	EFO_0004614
Disease	Sezary Syndrome	CHD3 DNMT3A	2.44e-03	27	80	2	C0036920
Disease	Malignant neoplasm of breast	SLC5A5 C5orf34 CYP3A4 WBP4 LAMA2 MMP1 LEPR DNMT3A CRX	2.48e-03	1074	80	9	C0006142
Disease	myocardial infarction (is_implicated_in)	PSMA6 MMP1 F5	2.50e-03	99	80	3	DOID:5844 (is_implicated_in)
Disease	response to antineoplastic agent	GALNT14 SLC44A5 RYR2	2.50e-03	99	80	3	GO_0097327

Protein segments in the cluster

Peptide	Gene	Start	Entry
VNWGMREYKIYPYEL	ABLIM3	611	O94929
YKDAFMKANPGYKWC	BBX	136	Q8WY36
EEEKNPYKEVYTDMW	DNMT3A	426	Q9Y6K1
GYMWEYPIAKAYVDA	ACADL	391	P28330
WRPSNKMLGKIYDYV	CALCR	361	P30988
MGFTVYEYSVWDPKK	GOT1L1	146	Q8NHS2
ETWYYGPCGKRMKQF	BAZ2A	576	Q9UIF9
WGMREYKIYPYDSLI	ABLIM2	541	Q6H8Q1
GVKSEYMKRYQEPRW	CCSAP	6	Q6IQ19
VLDEWKEYKMGVPTY	DCP2	86	Q8IU60
DYIVKNGEKWMDRYE	DYRK1A	146	Q13627
KYAKRITEWPPFEYM	CACNA1B	86	Q00975
YEYGYGSWEMIKMDP	CHD1	1266	O14646
YDMKKVWEGYPIQST	CERS2	161	Q96G23
DFDNMPFRGKYYNWK	ADAMTS6	626	Q9UKP5
ALYMKKLGYWVPFLE	CCNB3	1311	Q8WWL7
EMDLFTKYYSEWKGG	PPP2R3C	31	Q969Q6
YKEPFWRKKDYCGTM	MAOB	301	P27338
FFLYKLDFKMPDDVW	MADD	381	Q8WXG6
VKEYEMAIYKKYWPN	GREB1	1576	Q4ZG55
FKWYSVGYMKHLDRD	NLRP11	521	P59045
KVMAYVPDAVWYDYE	MGAM	776	O43451
DMECHKKYGKVWGFY	CYP3A4	61	P08684
QKLNGWYMEKEEPIY	ECPAS	1441	Q5VYK3
NYGKGIEWYRKKMPF	HS3ST5	131	Q8IZT8
SWVERYYADIAKMPA	PLXNA1	1811	Q9UIW2
ELWQEDPYEYIRMKF	IPO7	366	O95373
WEMQFKEKYDYVGRL	PGRMC2	186	O15173
CKSFKWYLDNVYPEM	GALNT11	441	Q8NCW6
DWMVRYVPYFKDKGD	FOXO6	116	A8MYZ6
SPSDYKLMYFIIEWK	LEPR	761	P48357
IPKGYRKDKFVWMDY	L3MBTL4	151	Q8NA19
MTEKEWKYYGDDPRV	LAMA2	1306	P24043
WPDEYALKEYGVMRV	PTPN11	371	Q06124
SYWEGKDFRTMLYKD	PTPRO	156	Q16827
VIDKAWFDYLGKYDM	GALNT14	286	Q96FL9
ASVEIMGYKDFKYCW	APOBEC3F	326	Q8IUX4
IYEWMVKSVPYFKDK	FOXO1	186	Q12778
KVWEVAAPYIEKYRM	HAL	611	P42357
EAMQKWYYKDPQGEI	GIGYF2	531	Q6Y7W6
SYGYPKEEMIYRWRK	GABRG3	191	Q99928
VKKMWEEYPDVYGVR	CHD2	96	O14647
CKKRDDYLEWPEYFM	DCTD	6	P32321
EMEEKYYRFGIKPEW	CHD3	616	Q12873
MWAPKFYVVTYTGDK	CHD3	806	Q12873
GAFATYYWAMKKPDD	SLC44A5	481	Q8NCS7
DMECYKKYRKVWGIY	CYP3A7	61	P24462
KRKVYMYYWPGCEVE	ENPP6	131	Q6UWR7
YSYPELVKMVWYKGV	C5orf34	326	Q96MH7
KKWYYELMVDHTEPF	RYR2	671	Q92736
WKFTYNPMDPLDYKD	CRX	276	O43186
NYEKGLEWYRNVMPK	HS3ST4	236	Q9Y661
EKYWKVNKPMELYYA	RNF2	316	Q99496
EMKKDWLFAPHYRYY	PSMD6	281	Q15008
YKVADYGMWERGDKT	PHKA2	176	P46019
GECVAFYYMWKKSER	MIER1	321	Q8N108
YAMNYWRKLGAPSEK	OVGP1	241	Q12889
RDWMYKHRFKAYPSE	TGIF2LX	66	Q8IUE1
RDWMYKHRFKAYPSE	TGIF2LY	66	Q8IUE0
WDYAPVIPANMDKKY	F5	361	P12259
KYWRYDEYKRSMDPG	MMP1	396	P03956
WDPFVKSYVEMLEFY	TAF1A	236	Q15573
EKAMYPDYFAKREQW	NDUFB9	111	Q9Y6M9
RVWYAAFYAKKMDKP	PRDM15	521	P57071
PFVMDYYVRRSDWKF	HCAR3	81	P49019
FDGKREDYFPDLMKW	SETD3	71	Q86TU7
WPMDKGVFIAYDDDK	WDR19	566	Q8NEZ3
KIPYEEFFGQGWMKL	RASGRF1	1056	Q13972
AYAMKEFGWPLEKAY	SSH1	406	Q8WYL5
YNWVGDYEDPNKMKR	CNKSR2	446	Q8WXI2
MWSKYPLDVQKEFGY	SLC7A6OS	286	Q96CW6
WKYKYGYEIPVDMLC	PSMA6	101	P60900
SKYGEYEWVHKPREM	RPF1	326	Q9H9Y2
VYWYRQLPEEGLKFM	TRBV18	51	A0A087X0M5
VPSEAYRYGLKFLWM	SLC5A5	76	Q92911
YTDPSYFFDLWKEKM	WASF3	151	Q9UPY6
MADYWKSQPKKFCDY	WBP4	1	O75554
DYYRQGRIAKMPVKW	AXL	701	P30530
FYWMYVGTRGPEEKK	SAYSD1	131	Q9NPB0
VDYEEKYGRMFPREW	VPS53	296	Q5VIR6
FMGRFYEWEPFAEVK	THSD4	326	Q6ZMP0
DWEPEMKKRYYDEVE	USP11	746	P51784
AIVYPLMKEYFKEWD	TFIP11	426	Q9UBB9
YEMEGIEWEPIKYFN	MYO1H	431	Q8N1T3