Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionstructural constituent of skin epidermis

KRT6A KRT6B KRT82 KRT84 KRT6C KRT36

1.01e-07431066GO:0030280
GeneOntologyMolecularFunctioncytoskeletal anchor activity

ANK1 MAP1A OBSL1 SPTBN4

7.35e-06241064GO:0008093
GeneOntologyBiologicalProcessintermediate filament organization

KRT6A KRT6B KRT82 KRT84 KRT6C KRT36

1.72e-06751006GO:0045109
GeneOntologyBiologicalProcessintermediate filament cytoskeleton organization

KRT6A KRT6B KRT82 KRT84 KRT6C KRT36

8.69e-06991006GO:0045104
GeneOntologyBiologicalProcessintermediate filament-based process

KRT6A KRT6B KRT82 KRT84 KRT6C KRT36

9.21e-061001006GO:0045103
GeneOntologyBiologicalProcesskeratinization

KRT6A KRT6B KRT82 KRT84 KRT6C

6.53e-05871005GO:0031424
GeneOntologyCellularComponentkeratin filament

KRT6A KRT6B KRT82 KRT84 KRT6C KRT36

6.37e-0697986GO:0045095
GeneOntologyCellularComponentCul3-RING ubiquitin ligase complex

KBTBD8 KLHL22 KLHL7 GAN

3.29e-0539984GO:0031463
GeneOntologyCellularComponentciliary pocket membrane

EHD3 EHD1

6.51e-053982GO:0020018
GeneOntologyCellularComponentciliary pocket

EHD3 EHD1

6.51e-053982GO:0020016
GeneOntologyCellularComponentintermediate filament

KRT6A KRT6B KRT82 KRT84 KRT6C KRT36

7.04e-04227986GO:0005882
GeneOntologyCellularComponentspectrin

SPTBN4 SPTBN5

7.67e-049982GO:0008091
GeneOntologyCellularComponentcell body fiber

SPTBN4 ASL

1.16e-0311982GO:0070852
GeneOntologyCellularComponentpostsynaptic endosome membrane

MKLN1 SNX1

1.16e-0311982GO:0098895
GeneOntologyCellularComponentsupramolecular fiber

KRT6A KRT6B ANK1 MAP1A KRT82 SYNE1 KRT84 OBSL1 CCDC57 KLHL22 SPTBN4 KRT6C KRT36 SCN3B

1.18e-0311799814GO:0099512
GeneOntologyCellularComponentsupramolecular polymer

KRT6A KRT6B ANK1 MAP1A KRT82 SYNE1 KRT84 OBSL1 CCDC57 KLHL22 SPTBN4 KRT6C KRT36 SCN3B

1.25e-0311879814GO:0099081
GeneOntologyCellularComponentubiquitin ligase complex

WWP1 KBTBD8 KLHL22 KLHL7 MKLN1 GAN PRKN

1.35e-03352987GO:0000151
GeneOntologyCellularComponentintermediate filament cytoskeleton

KRT6A KRT6B KRT82 KRT84 KRT6C KRT36

1.50e-03263986GO:0045111
MousePhenoabnormal filiform papillae morphology

KRT6A KRT6B KRT36

5.11e-067753MP:0000763
DomainBACK

KLHL10 KBTBD8 BTBD9 KLHL22 KLHL7 GAN KLHL18

2.91e-0860997SM00875
DomainBACK

KLHL10 KBTBD8 BTBD9 KLHL22 KLHL7 GAN KLHL18

3.27e-0861997PF07707
DomainBACK

KLHL10 KBTBD8 BTBD9 KLHL22 KLHL7 GAN KLHL18

3.27e-0861997IPR011705
DomainKelch_1

KLHL10 KBTBD8 KLHL22 KLHL7 MKLN1 GAN KLHL18

8.65e-0870997PF01344
DomainKelch_1

KLHL10 KBTBD8 KLHL22 KLHL7 MKLN1 GAN KLHL18

8.65e-0870997IPR006652
DomainBTB-kelch_protein

KLHL10 KBTBD8 KLHL22 KLHL7 GAN KLHL18

9.90e-0843996IPR017096
DomainKeratin_2_head

KRT6A KRT6B KRT82 KRT84 KRT6C

1.48e-0724995IPR032444
DomainKeratin_2_head

KRT6A KRT6B KRT82 KRT84 KRT6C

1.48e-0724995PF16208
DomainKeratin_II

KRT6A KRT6B KRT82 KRT84 KRT6C

2.28e-0726995IPR003054
DomainKelch

KLHL10 KBTBD8 KLHL22 KLHL7 GAN KLHL18

6.17e-0758996SM00612
DomainGal_Oxase/kelch_b-propeller

KLHL10 KBTBD8 KLHL22 MKLN1 GAN KLHL18

6.83e-0759996IPR011043
DomainIntermediate_filament_CS

KRT6A KRT6B KRT82 KRT84 KRT6C KRT36

1.01e-0663996IPR018039
DomainFilament

KRT6A KRT6B KRT82 KRT84 KRT6C KRT36

2.06e-0671996SM01391
DomainIF

KRT6A KRT6B KRT82 KRT84 KRT6C KRT36

2.24e-0672996PS00226
DomainFilament

KRT6A KRT6B KRT82 KRT84 KRT6C KRT36

2.43e-0673996PF00038
DomainIF

KRT6A KRT6B KRT82 KRT84 KRT6C KRT36

3.08e-0676996IPR001664
Domain-

KBTBD8 KLHL22 KLHL7 MKLN1 GAN

5.40e-06489952.120.10.80
DomainBTB

KLHL10 KBTBD8 BTBD9 KLHL22 KLHL7 GAN KLHL18

6.19e-06131997PF00651
DomainKelch-typ_b-propeller

KBTBD8 KLHL22 KLHL7 MKLN1 GAN

1.07e-0555995IPR015915
DomainBTB

KLHL10 KBTBD8 BTBD9 KLHL22 KLHL7 GAN KLHL18

2.28e-05160997PS50097
DomainEHD1/EHD3

EHD3 EHD1

2.78e-052992IPR029951
DomainBTB

KLHL10 KBTBD8 BTBD9 KLHL22 KLHL7 GAN KLHL18

4.85e-05180997SM00225
DomainBTB/POZ_dom

KLHL10 KBTBD8 BTBD9 KLHL22 KLHL7 GAN KLHL18

5.77e-05185997IPR000210
DomainSKP1/BTB/POZ

KLHL10 KBTBD8 BTBD9 KLHL22 KLHL7 GAN KLHL18

6.60e-05189997IPR011333
DomainActinin_actin-bd_CS

SYNE1 SPTBN4 SPTBN5

2.37e-0423993IPR001589
DomainSpectrin

SYNE1 SPTBN4 SPTBN5

2.37e-0423993PF00435
DomainACTININ_2

SYNE1 SPTBN4 SPTBN5

2.37e-0423993PS00020
DomainACTININ_1

SYNE1 SPTBN4 SPTBN5

2.37e-0423993PS00019
DomainEHD_N

EHD3 EHD1

2.75e-045992IPR031692
DomainEHD_N

EHD3 EHD1

2.75e-045992PF16880
DomainSpectrin_repeat

SYNE1 SPTBN4 SPTBN5

4.78e-0429993IPR002017
DomainSpectrin/alpha-actinin

SYNE1 SPTBN4 SPTBN5

6.41e-0432993IPR018159
DomainSPEC

SYNE1 SPTBN4 SPTBN5

6.41e-0432993SM00150
DomainMethyltranfer_dom

METTL24 EEF1AKMT2

7.63e-048992IPR025714
DomainGal_Oxidase_b-propeller

KLHL10 GAN KLHL18

7.67e-0434993IPR015916
DomainCl-channel_core

CLCN2 CLCNKB

9.77e-049992IPR014743
Domain-

CLCN2 CLCNKB

9.77e-0499921.10.3080.10
DomainPH_dom-spectrin-type

SPTBN4 SPTBN5

9.77e-049992IPR001605
DomainVoltage_CLC

CLCN2 CLCNKB

9.77e-049992PF00654
DomainCl-channel_volt-gated

CLCN2 CLCNKB

9.77e-049992IPR001807
DomainEF-hand_4

EHD3 EHD1

1.22e-0310992PF12763
DomainEH

EHD3 EHD1

1.48e-0311992PS50031
DomainEH

EHD3 EHD1

1.48e-0311992SM00027
DomainEH_dom

EHD3 EHD1

1.48e-0311992IPR000261
Domain-

ANK1 NLRP3 NLRP10 CARD14

1.51e-03939941.10.533.10
DomainKeratin_I

KRT82 KRT84 KRT36

1.63e-0344993IPR002957
DomainDEATH-like_dom

ANK1 NLRP3 NLRP10 CARD14

1.90e-0399994IPR011029
DomainG_DYNAMIN_dom

EHD3 EHD1

2.43e-0314992IPR030381
DomainG_DYNAMIN_2

EHD3 EHD1

2.43e-0314992PS51718
Domain-

ZCCHC2 PIK3C2B SNX1

2.50e-03519933.30.1520.10
DomainPhox

ZCCHC2 PIK3C2B SNX1

2.64e-0352993IPR001683
DomainDynamin_GTPase

EHD3 EHD1

2.79e-0315992IPR001401
DomainDynamin_N

EHD3 EHD1

2.79e-0315992PF00350
DomainDynamin_SF

EHD3 EHD1

2.79e-0315992IPR022812
DomainCBS

CLCN2 CLCNKB

3.18e-0316992SM00116
DomainCBS_dom

CLCN2 CLCNKB

4.97e-0320992IPR000644
DomainCBS

CLCN2 CLCNKB

4.97e-0320992PF00571
DomainCBS

CLCN2 CLCNKB

4.97e-0320992PS51371
DomainMAGE_N

MAGEB3 MAGEB10

4.97e-0320992SM01392
DomainCH

SYNE1 SPTBN4 SPTBN5

4.97e-0365993SM00033
PathwayREACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS

ANK1 SPTBN4 SPTBN5

1.56e-0510733MM15112
PathwayREACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS

ANK1 SPTBN4 SPTBN5 SCN3B

1.87e-0531734M877
PathwayREACTOME_FORMATION_OF_THE_CORNIFIED_ENVELOPE

KRT6A KRT6B KRT82 KRT84 KRT6C KRT36

5.39e-05129736M27649
PathwayREACTOME_FORMATION_OF_THE_CORNIFIED_ENVELOPE

KRT6A KRT6B KRT82 KRT84 KRT36

8.61e-0587735MM15351
Pubmed

Genetic variants in pachyonychia congenita-associated keratins increase susceptibility to tooth decay.

KRT6A KRT6B KRT6C

2.83e-083107329357356
Pubmed

Cloning and characterization of multiple human genes and cDNAs encoding highly related type II keratin 6 isoforms.

KRT6A KRT6B KRT6C

2.83e-08310737543104
Pubmed

New consensus nomenclature for mammalian keratins.

KRT6A KRT6B KRT82 KRT84 KRT6C KRT36

4.34e-0863107616831889
Pubmed

Hague (Hag). A new mouse hair mutation with an unstable semidominant allele.

KRT6A KRT6B KRT82 KRT84

1.50e-0716107412399393
Pubmed

Update on the Kelch-like (KLHL) gene family.

KLHL10 KLHL22 KLHL7 GAN KLHL18

1.72e-0741107523676014
Pubmed

Pachyonychia Congenita

KRT6A KRT6B KRT6C

2.82e-075107320301457
Pubmed

A ubiquitin-based effector-to-inhibitor switch coordinates early brain, craniofacial, and skin development.

KBTBD8 GIT2 BTBD9 KLHL22 KLHL7 KLHL18

3.04e-0787107637495603
Pubmed

Novel CUL3 Variant Causing Familial Hyperkalemic Hypertension Impairs Regulation and Function of Ubiquitin Ligase Activity.

KBTBD8 BTBD9 KLHL22 KLHL7 KLHL18

9.25e-0757107534878901
Pubmed

Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy.

KRT6B KRT82 SYNE1 KRT84 SPTBN5 CELSR3 GAN

1.92e-06187107726460568
Pubmed

Characterization of new members of the human type II keratin gene family and a general evaluation of the keratin gene domain on chromosome 12q13.13.

KRT6A KRT82 KRT84

2.35e-069107315737194
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

SART3 CACNA1E KRT6A STRN3 KRT6B SYNE1 PCDHGA2 KRT84 NCBP1 CCDC57 NUP205 SPTBN4 C2CD3 KRT6C SND1 RGPD3

8.67e-0614421071635575683
Pubmed

A reporter transgene based on a human keratin 6 gene promoter is specifically expressed in the periderm of mouse embryos.

KRT6A KRT6B

9.38e-062107211118885
Pubmed

[Coxsackie virus B3 (CVB3) triggers the activation of NLRP3 in mouse macrophages by activating nicotinamide adenine dinucleotide kinase 2 (NADK2)].

NADK2 NLRP3

9.38e-062107236631013
Pubmed

Expression of MK6a dominant-negative and C-terminal mutant transgenes in mice has distinct phenotypic consequences in the epidermis and hair follicle.

KRT6A KRT6B

9.38e-062107210550543
Pubmed

The mouse keratin 6 isoforms are differentially expressed in the hair follicle, footpad, tongue and activated epidermis.

KRT6A KRT6B

9.38e-062107210550545
Pubmed

The two functional keratin 6 genes of mouse are differentially regulated and evolved independently from their human orthologs.

KRT6A KRT6B

9.38e-06210729790766
Pubmed

SUMOylation of EHD3 Modulates Tubulation of the Endocytic Recycling Compartment.

EHD3 EHD1

9.38e-062107226226295
Pubmed

FUT2: filling the gap between genes and environment in Behçet's disease?

HLA-B FUT2

9.38e-062107224326010
Pubmed

Collapse of the keratin filament network through the expression of mutant keratin 6c observed in a case of focal plantar keratoderma.

KRT6A KRT6C

9.38e-062107223662636
Pubmed

PARK2 attenuates house dust mite-induced inflammatory reaction, pyroptosis and barrier dysfunction in BEAS-2B cells by ubiquitinating NLRP3.

NLRP3 PRKN

9.38e-062107233527027
Pubmed

Discovery of a novel murine keratin 6 (K6) isoform explains the absence of hair and nail defects in mice deficient for K6a and K6b.

KRT6A KRT6B

9.38e-062107211489919
Pubmed

The interplay between HLA-B and NLRP3 polymorphisms may be associated with the genetic susceptibility of gout.

HLA-B NLRP3

9.38e-062107236057006
Pubmed

Delayed wound healing in keratin 6a knockout mice.

KRT6A KRT6B

9.38e-062107210866680
Pubmed

Structural features and sites of expression of a new murine 65 kD and 48 kD hair-related keratin pair, associated with a special type of parakeratotic epithelial differentiation.

KRT84 KRT36

9.38e-06210721385239
Pubmed

Introducing a null mutation in the mouse K6alpha and K6beta genes reveals their essential structural role in the oral mucosa.

KRT6A KRT6B

9.38e-062107210953016
Pubmed

The complete cDNA and deduced amino acid sequence of a type II mouse epidermal keratin of 60,000 Da: analysis of sequence differences between type I and type II keratins.

KRT6A KRT6B

9.38e-06210726207530
Pubmed

Cytokeratins mediate epithelial innate defense through their antimicrobial properties.

KRT6A KRT6B

9.38e-062107223006328
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

OXR1 HLA-B SYNE1 OBSL1 NCBP1 STAB1 SPTBN4 RPRD1A CELSR3 KLHL7 SGSM2 MKLN1 ALDH5A1 SNX1 SH3BP5

9.39e-0612851071535914814
Pubmed

Charting the molecular network of the drug target Bcr-Abl.

KRT6A KRT6B KRT82 KRT84 KRT6C PIK3C2B KRT36

1.92e-05266107719380743
Pubmed

Suppression of DDX39B sensitizes ovarian cancer cells to DNA-damaging chemotherapeutic agents via destabilizing BRCA1 mRNA.

KRT6A KRT6B KRT84 NCBP1 KRT6C

2.08e-05107107532989256
Pubmed

Keratin expression provides novel insight into the morphogenesis and function of the companion layer in hair follicles.

KRT6A KRT6B

2.81e-053107217170733
Pubmed

Overcoming functional redundancy to elicit pachyonychia congenita-like nail lesions in transgenic mice.

KRT6A KRT6B

2.81e-053107215601842
Pubmed

Cytokeratin 5/6 expression in bladder cancer: association with clinicopathologic parameters and prognosis.

KRT6A KRT6B

2.81e-053107229587848
Pubmed

βIV Spectrinopathies Cause Profound Intellectual Disability, Congenital Hypotonia, and Motor Axonal Neuropathy.

ANK1 SPTBN4

2.81e-053107229861105
Pubmed

E3 ubiquitin ligase RNF187 promotes growth of spermatogonia via lysine 48-linked polyubiquitination-mediated degradation of KRT36/KRT84.

KRT84 KRT36

2.81e-053107237738023
Pubmed

A role for keratins in supporting mitochondrial organization and function in skin keratinocytes.

KRT6A KRT6B

2.81e-053107232213122
Pubmed

Differential roles of C-terminal Eps15 homology domain proteins as vesiculators and tubulators of recycling endosomes.

EHD3 EHD1

2.81e-053107224019528
Pubmed

Activation of NLRP3 inflammasome in lung epithelial cells triggers radiation-induced lung injury.

DPYSL4 NLRP3

2.81e-053107236694200
Pubmed

Parkin regulates microglial NLRP3 and represses neurodegeneration in Parkinson's disease.

NLRP3 PRKN

2.81e-053107237029500
Pubmed

Early steps in primary cilium assembly require EHD1/EHD3-dependent ciliary vesicle formation.

EHD3 EHD1

2.81e-053107225686250
Pubmed

EHD3: a protein that resides in recycling tubular and vesicular membrane structures and interacts with EHD1.

EHD3 EHD1

2.81e-053107212121420
Pubmed

Mice expressing a mutant Krt75 (K6hf) allele develop hair and nail defects resembling pachyonychia congenita.

KRT6A KRT6B

2.81e-053107217851587
Pubmed

PINK1-parkin pathway of mitophagy protects against contrast-induced acute kidney injury via decreasing mitochondrial ROS and NLRP3 inflammasome activation.

NLRP3 PRKN

2.81e-053107231229841
Pubmed

A small deletion hotspot in the type II keratin gene mK6irs1/Krt2-6g on mouse chromosome 15, a candidate for causing the wavy hair of the caracul (Ca) mutation.

KRT6A KRT6B

2.81e-053107214573483
Pubmed

Loss of keratin 6 (K6) proteins reveals a function for intermediate filaments during wound repair.

KRT6A KRT6B

2.81e-053107214568992
Pubmed

Parkin deficiency modulates NLRP3 inflammasome activation by attenuating an A20-dependent negative feedback loop.

NLRP3 PRKN

2.81e-053107229665074
Pubmed

Identification of a cloned sequence activated during multi-stage carcinogenesis in mouse skin.

KRT6A KRT6B

2.81e-05310721713533
Pubmed

The complement of native alpha-keratin polypeptides of hair-forming cells: a subset of eight polypeptides that differ from epithelial cytokeratins.

KRT82 KRT84

2.81e-05310722431943
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

SART3 KRT6A STRN3 KRT6B OXR1 MAP1A SYNE1 DPYSL4 SCRN1 TRIM3 EHD3 SPTBN4 SND1 EHD1 SCAPER

3.29e-0514311071537142655
Pubmed

Bcl11b/Ctip2 is required for development of lingual papillae in mice.

KRT6A KRT6B KRT84

3.62e-0521107327287879
Pubmed

DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation.

MAP1A SYNE1 SPTBN4

4.18e-0522107312812986
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

CACNA1E STRN3 SYNE1 DPYSL4 GIT2 BTBD9 TRIM3 EHD3 SPTBN4 KLHL7 RGPD3 SH3BP5

4.22e-059631071228671696
Pubmed

A novel missense variant in CUL3 shows altered binding ability to BTB-adaptor proteins leading to diverse phenotypes of CUL3-related disorders.

BTBD9 KLHL22 KLHL18

4.79e-0523107333130828
Pubmed

Interactions between EHD proteins and Rab11-FIP2: a role for EHD3 in early endosomal transport.

EHD3 EHD1

5.60e-054107216251358
Pubmed

Neuronal NLRP3 is a parkin substrate that drives neurodegeneration in Parkinson's disease.

NLRP3 PRKN

5.60e-054107235654037
Pubmed

C-terminal EH-domain-containing proteins: consensus for a role in endocytic trafficking, EH?

EHD3 EHD1

5.60e-054107216155252
Pubmed

EHD3 Protein Is Required for Tubular Recycling Endosome Stabilization, and an Asparagine-Glutamic Acid Residue Pair within Its Eps15 Homology (EH) Domain Dictates Its Selective Binding to NPF Peptides.

EHD3 EHD1

5.60e-054107227189942
Pubmed

Keratin 6 regulates collective keratinocyte migration by altering cell-cell and cell-matrix adhesion.

KRT6A KRT6B

5.60e-054107230389720
Pubmed

A review of the clinical phenotype of 254 patients with genetically confirmed pachyonychia congenita.

KRT6A KRT6B

5.60e-054107222264670
Pubmed

Mouse models in preclinical studies for pachyonychia congenita.

KRT6A KRT6B

5.60e-054107216250208
Pubmed

Role of the EHD Family of Endocytic Recycling Regulators for TCR Recycling and T Cell Function.

EHD3 EHD1

5.60e-054107229212907
Pubmed

Shared as well as distinct roles of EHD proteins revealed by biochemical and functional comparisons in mammalian cells and C. elegans.

EHD3 EHD1

5.60e-054107217233914
Pubmed

EHD2, EHD3, and EHD4 encode novel members of a highly conserved family of EH domain-containing proteins.

EHD3 EHD1

5.60e-054107210673336
Pubmed

Phosphorylation of human keratin 8 in vivo at conserved head domain serine 23 and at epidermal growth factor-stimulated tail domain serine 431.

KRT6A KRT6C

5.60e-05410729054461
Pubmed

NLRP10 is a NOD-like receptor essential to initiate adaptive immunity by dendritic cells.

NLRP3 NLRP10

5.60e-054107222538615
Pubmed

Rabenosyn-5 and EHD1 interact and sequentially regulate protein recycling to the plasma membrane.

EHD3 EHD1

5.60e-054107215020713
Pubmed

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

SYNE1 OBSL1 SCRN1 GIT2 STAB1 SMG7

7.19e-05225107612168954
Pubmed

Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development.

CACNA1E CACNA2D2 CLCN2 CLCNKB SCN3B

7.27e-05139107516985003
Pubmed

Airway hillocks are injury-resistant reservoirs of unique plastic stem cells.

KRT6A KRT6B

9.32e-055107238693267
Pubmed

EH domain proteins regulate cardiac membrane protein targeting.

EHD3 EHD1

9.32e-055107220489164
Pubmed

Role for keratins 6 and 17 during wound closure in embryonic mouse skin.

KRT6A KRT6B

9.32e-055107212557214
Pubmed

Three epidermal and one simple epithelial type II keratin genes map to human chromosome 12.

KRT6A KRT6B

9.32e-05510721713141
Pubmed

The diagnostic utility of D2-40, calretinin, CK5/6, desmin and MOC-31 in the differentiation of mesothelioma from adenocarcinoma in pleural effusion cytology.

KRT6A KRT6B

9.32e-055107223075894
Pubmed

Hair follicle stem cells regulate retinoid metabolism to maintain the self-renewal niche for melanocyte stem cells.

KRT6A KRT6B

9.32e-055107231898934
Pubmed

Differential gene expression profiling of the molar tooth germ in peroxisome proliferator-activated receptor-alpha (PPAR-alpha) knockout mouse and in wild-type mouse: molar tooth phenotype of PPAR-alpha knockout mouse.

CACNA1E KRT6A KRT6B

1.32e-0432107319320717
Pubmed

Identification of 14-3-3sigma mutation causing cutaneous abnormality in repeated-epilation mutant mouse.

KRT6A KRT6B

1.40e-046107216239341
Pubmed

Identification of functional variants for cleft lip with or without cleft palate in or near PAX7, FGFR2, and NOG by targeted sequencing of GWAS loci.

KRT6A KRT6B

1.40e-046107225704602
Pubmed

MICAL-L1 links EHD1 to tubular recycling endosomes and regulates receptor recycling.

EHD3 EHD1

1.40e-046107219864458
Pubmed

p63(+)Krt5(+) distal airway stem cells are essential for lung regeneration.

KRT6A KRT6B

1.40e-046107225383540
Pubmed

Keratin 6 is not essential for mammary gland development.

KRT6A KRT6B

1.40e-046107216790075
Pubmed

Identification of 4370 expressed sequence tags from a 3'-end-specific cDNA library of human skeletal muscle by DNA sequencing and filter hybridization.

ANK1 OBSL1 PIK3C2B

1.44e-043310738681137
Pubmed

Early embryonic expression patterns of the mouse Flamingo and Prickle orthologues.

LMCD1 CELSR3

1.95e-047107217937400
Pubmed

Leishmania RNA virus exacerbates Leishmaniasis by subverting innate immunity via TLR3-mediated NLRP3 inflammasome inhibition.

NLRP3 PRKN

1.95e-047107231754185
Pubmed

PYPAF3, a PYRIN-containing APAF-1-like protein, is a feedback regulator of caspase-1-dependent interleukin-1beta secretion.

NLRP3 NLRP10

1.95e-047107215817483
Pubmed

Deciphering TGF-β3 function in medial edge epithelium specification and fusion during mouse secondary palate development.

KRT6A KRT6B

1.95e-047107225104574
Pubmed

Structural, expression, and evolutionary analysis of mouse CIAS1.

NLRP3 NLRP10

1.95e-047107215302403
Pubmed

Frizzled6 deficiency disrupts the differentiation process of nail development.

KRT6A KRT6B

1.95e-047107223439395
Pubmed

Prediction of local recurrence, distant metastases, and death after breast-conserving therapy in early-stage invasive breast cancer using a five-biomarker panel.

KRT6A KRT6B

1.95e-047107219720911
Pubmed

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.

SART3 OBSL1 GIT2 MTFR1L NUP205 EHD3 RPRD1A SND1 KLHL7 MKLN1 GAN FGD6 PCK2

2.13e-0413211071327173435
Pubmed

Proximity Mapping of CCP6 Reveals Its Association with Centrosome Organization and Cilium Assembly.

STRN3 C2CD3 SMG7

2.21e-0438107336674791
Pubmed

Myosin Vb interacts with Rab8a on a tubular network containing EHD1 and EHD3.

EHD3 EHD1

2.59e-048107217507647
Pubmed

An in vivo comparative study of sonic, desert and Indian hedgehog reveals that hedgehog pathway activity regulates epidermal stem cell homeostasis.

KRT6A KRT6B

2.59e-048107215371305
Pubmed

Grainyhead-like factor Get1/Grhl3 regulates formation of the epidermal leading edge during eyelid closure.

KRT6A KRT6B

2.59e-048107218485343
Pubmed

Topical Aminosalicylic Acid Improves Keratinocyte Differentiation in an Inducible Mouse Model of Harlequin Ichthyosis.

KRT6A KRT6B

2.59e-048107233294854
Pubmed

Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.

STRN3 CCPG1 HLA-B COQ8B SMG7 EHD1 SCAPER FGD6 PCK2

2.85e-04689107936543142
Pubmed

A mutant mouse with severe anemia and skin abnormalities controlled by a new allele of the flaky skin (fsn) locus.

KRT6A KRT6B

3.33e-049107216093647
Pubmed

Type II keratins precede type I keratins during early embryonic development.

KRT6A KRT6B

3.33e-049107216180309
Pubmed

Periderm Fate during Palatogenesis: TGF-β and Periderm Dedifferentiation.

KRT6A KRT6B

3.33e-049107236751050
Pubmed

Changing expression of chloride channels during preimplantation mouse development.

CLCN2 CLCNKB

3.33e-049107223115349
Pubmed

RIP4 regulates epidermal differentiation and cutaneous inflammation.

KRT6A KRT6B

3.33e-049107219626033
InteractionRTTN interactions

HLA-B OBSL1 GAN PRKN

2.01e-0619994int:RTTN
InteractionPHTF1 interactions

KRT6A KRT6B KRT84 KRT6C

2.50e-0620994int:PHTF1
InteractionCELSR3 interactions

SPTBN4 CELSR3 SGSM2 SCAPER GAN

3.02e-0646995int:CELSR3
InteractionKRT6B interactions

KRT6A KRT6B KRT84 OBSL1 GAN PRKN KRT36

3.98e-06132997int:KRT6B
InteractionKRT84 interactions

KRT6A KRT6B KRT84 KRT6C GAN

4.15e-0649995int:KRT84
InteractionKRT16 interactions

KRT6A KRT6B KRT82 KRT84 OBSL1 KRT6C GAN PRKN

5.79e-06197998int:KRT16
InteractionDES interactions

KRT6A KRT6B KRT84 KLHL22 KRT6C GAN PRKN

1.30e-05158997int:DES
InteractionKRT75 interactions

KRT6A KRT6B KRT84 KRT6C GAN PRKN KRT36

3.12e-05181997int:KRT75
InteractionKRT36 interactions

KRT6A KRT6B KRT82 KRT6C KRT36

3.18e-0574995int:KRT36
InteractionKRT82 interactions

KRT82 OBSL1 GAN KRT36

3.19e-0537994int:KRT82
InteractionGAN interactions

KRT6B KRT82 SYNE1 KRT84 KBTBD8 SPTBN5 CELSR3 GAN

3.53e-05253998int:GAN
InteractionKRT14 interactions

KRT6A KRT6B KRT84 OBSL1 KRT6C GAN PRKN

4.54e-05192997int:KRT14
InteractionKRT7 interactions

KRT6A KRT6B KRT84 KRT6C PRKN

4.64e-0580995int:KRT7
InteractionKRT5 interactions

KRT6A KRT6B KRT84 OBSL1 KRT6C PRKN KRT36

4.69e-05193997int:KRT5
InteractionKRT76 interactions

KRT6A KRT84 CCDC57 PRKN KRT36

5.87e-0584995int:KRT76
InteractionSPTBN5 interactions

SPTBN5 GAN PRKN

6.15e-0516993int:SPTBN5
InteractionKRT8 interactions

KRT6A KRT6B KRT84 OBSL1 GIT2 NUP205 SMG7 KRT6C PRKN KRT36

6.24e-054419910int:KRT8
InteractionSCP2D1 interactions

EHD3 EHD1

7.14e-053992int:SCP2D1
InteractionKRT33B interactions

KRT6B KRT82 OBSL1 KRT6C GAN

9.54e-0593995int:KRT33B
InteractionKRT6A interactions

KRT6A KRT6B KRT84 OBSL1 KRT6C KRT36

1.39e-04160996int:KRT6A
CytobandEnsembl 112 genes in cytogenetic band chr7q11

SPDYE17 SPDYE10 SPDYE9 SPDYE12 SPDYE11 SPDYE13 SPDYE15 ASL SPDYE8 SPDYE14

1.11e-0927110910chr7q11
CytobandEnsembl 112 genes in cytogenetic band chr12q13

KRT6A KRT6B KRT82 KRT84 KRT6C PRPF40B SPRYD4

7.13e-054231097chr12q13
Cytoband7q11.23

SPDYE10 SPDYE9 SPDYE8 SPDYE14

8.79e-059710947q11.23
Cytoband12q13.13

KRT6A KRT6B KRT6C

5.58e-0467109312q13.13
Cytoband12q24.1

SART3 GIT2

5.75e-0415109212q24.1
CytobandEnsembl 112 genes in cytogenetic band chr3p21

CACNA2D2 STAB1 CELSR3 GPR62 KLHL18

9.75e-043161095chr3p21
CytobandXp21.3

MAGEB3 MAGEB10

2.17e-03291092Xp21.3
GeneFamilyKeratins, type II

KRT6A KRT6B KRT82 KRT84 KRT6C

8.07e-0827755609
GeneFamilyKelch like|BTB domain containing

KLHL10 KLHL22 KLHL7 GAN KLHL18

8.10e-0742755617
GeneFamilyBasic leucine zipper proteins|BTB domain containing

KLHL10 KBTBD8 BTBD9 KLHL22 KLHL7 GAN KLHL18

1.37e-06134757861
GeneFamilyMethyltransferase like

METTL24 TRMT44 EEF1AKMT2

3.42e-0433753963
GeneFamilyEF-hand domain containing|Spectrins

SPTBN4 SPTBN5

3.52e-0477521113
GeneFamilyChloride voltage-gated channels

CLCN2 CLCNKB

7.48e-0410752302
GeneFamilySpeedy/RINGO cell cycle regulator family

SPDYE9 SPDYE8

1.09e-0312752756
GeneFamilyNLR family

NLRP3 NLRP10

4.79e-0325752666
GeneFamilyPyrin domain containing|Pyrin and HIN domain family

NLRP3 NLRP10

4.79e-0325752994
GeneFamilyCalcium voltage-gated channel subunits

CACNA1E CACNA2D2

5.17e-0326752253
CoexpressionTABULA_MURIS_SENIS_TONGUE_KERATINOCYTE_AGEING

KRT6A KRT6B HLA-B KRT84 KRT36

2.64e-06561025MM3852
Drugdithranol

KRT6A KRT6B KRT6C G6PD

1.11e-06181024CID000002202
Drugteleocidin B

KRT6A KRT6B KRT82 KRT84 KRT6C KRT36 ALG1

1.37e-061231027CID000072425
DrugSC-791

KRT6A KRT6B KRT6C

1.73e-0661023CID010291510
Drugplakin

KRT6A KRT6B SYNE1 SPTBN4 SPTBN5 KRT6C

1.85e-06821026CID000018752
Drughomocysteine thiolactone

KRT6A KRT6B HLA-B KRT82 KRT84 KRT6C KRT36

2.08e-061311027CID000107712
DrugButamben [94-25-7]; Down 200; 20.6uM; MCF7; HT_HG-U133A

AEN LMCD1 DPYSL4 GIT2 CLCN2 SMG7 SND1 PCSK7

2.76e-0619510286266_DN
DrugMK-6

KRT6A KRT6B SYNE1 KRT6C

3.77e-06241024CID005283547
DrugBhg-(2-1)fuc

KRT6A KRT6B KRT6C G6PD

4.47e-06251024CID005287784
Drugmethylitaconate

HLA-B SYNE1

1.99e-0521022CID000439700
Drugchrysarobin

KRT6A KRT6B KRT6C G6PD

2.24e-05371024CID000068111
Drugsulfur mustard

KRT6A KRT6B KRT82 KRT84 KRT6C KRT36

2.65e-051301026CID000010461
DrugMelatonin [73-31-4]; Down 200; 17.2uM; HL60; HT_HG-U133A

AEN GDPD3 C2CD3 CLCN2 CELSR3 SCAPER PCSK7

2.91e-0519610272431_DN
DrugAlbendazole [54965-21-8]; Down 200; 15uM; MCF7; HT_HG-U133A

LMCD1 TRIM3 SMG7 EHD1 PCSK7 GAN SNX1

3.01e-0519710277164_DN
DrugMefexamide hydrochloride [3413-64-7]; Down 200; 12.6uM; MCF7; HT_HG-U133A

STRN3 ZNF573 GIT2 TRIM3 EHD1 GAN ALDH5A1

3.01e-0519710277478_DN
DrugDexamethasone acetate [1177-87-3]; Down 200; 9.2uM; MCF7; HT_HG-U133A

GIT2 SMG7 SND1 KLHL7 EHD1 PCSK7 SNX1

3.11e-0519810276271_DN
Drug6-thioguanine; Down 200; 10uM; MCF7; HG-U133A

STRN3 KRT6B EHD3 KLHL7 GAN SRPK3 CARD14

3.11e-051981027642_DN
DrugAC1L9LMC

CACNA1E KRT6A KRT6B SYNE1 KRT6C

3.60e-05831025CID000448113
Drugclobestasol propionate

KRT6A KRT6B KRT6C

5.67e-05171023CID000002791
Drug2-hexadecyne

SYNE1 G6PD

5.94e-0531022CID014009124
DiseasePachyonychia Congenita, Jadassohn Lewandowsky Type

KRT6A KRT6B

6.39e-054972C1706595
Diseasepachyonychia congenita (is_implicated_in)

KRT6A KRT6B

6.39e-054972DOID:0050449 (is_implicated_in)
DiseasePachyonychia congenita syndrome

KRT6A KRT6B

6.39e-054972cv:C0265334
DiseasePachyonychia Congenita, Type 2 (disorder)

KRT6A KRT6B

6.39e-054972C1721007
DiseasePachyonychia Congenita

KRT6A KRT6B

1.06e-045972C0265334
Diseaselevel of N-sulphoglucosamine sulphohydrolase in blood serum

HLA-B CARD14

1.06e-045972OBA_2043486
Diseaselysine measurement

NADK2 PRKN SPRYD4

2.47e-0437973EFO_0005002
Diseasemeningitis

CACNA1E SCAPER

5.77e-0411972MONDO_0021108
Diseaseanemia (is_implicated_in)

ANK1 G6PD

9.49e-0414972DOID:2355 (is_implicated_in)
Diseasecognitive function measurement, self reported educational attainment

CACNA1E HLA-B CACNA2D2 STAB1 CLCN2 SND1

1.15e-03355976EFO_0004784, EFO_0008354
Diseasecoronary thrombosis, GM11992

METTL24 SCAPER

1.25e-0316972EFO_0001124, EFO_1000883
DiseaseLeft ventricular mass to end-diastolic volume ratio

HLA-B OBSL1

3.05e-0325972EFO_0010556

Protein segments in the cluster

PeptideGeneStartEntry
YRLVEVQWEQQEARS

AEN

266

Q8WTP8
EDLADNWHIRAVTVY

ALG1

201

Q9BT22
LDEFVRVWAEYDRAA

CACNA1E

1741

Q15878
VERVWRDQDLNTYSL

CACNA2D2

741

Q9NY47
YWEARRVARQAQLEA

SH3BP5

101

O60239
RADQYWNEVAVLDAI

ANK1

1536

P16157
YDEVDRRETDAVWLA

GIT2

286

Q14161
VYRREAVQQEWAEPD

ADAMTS14

206

Q8WXS8
DYEQLRDLQVWVIAR

PCDHGA2

521

Q9Y5H1
TFAAVVLYVENERWD

G6PD

336

P11413
AYRRAAEKWEVAEVV

NUP205

751

Q92621
DLERYVQDADVRWEY

KIAA0895L

356

Q68EN5
VQDADVRWEYCVRAK

KIAA0895L

361

Q68EN5
YRLERQEVGSEDWIQ

OBSL1

551

O75147
ALDRENVWAYELVVT

PCDHA11

411

Q9Y5I1
YEEIAQRSRAEAESW

KRT6C

341

P48668
YEEVARRSRADAEAW

KRT84

341

Q9NSB2
ARAAEAEAAVTWVAY

GPR62

266

Q9BZJ7
REDVALEQDTYWREL

MAP1A

1686

P78559
WYEEALRDEEERVQA

MAGEB3

306

O15480
WYTEALQDEEERARA

MAGEB10

306

Q96LZ2
TQEEDVPQVRRDWYV

NCBP1

156

Q09161
DVEWYQALVRSVAEG

GPR179

126

Q6PRD1
YEEIAQRSRAEAESW

KRT6A

341

P02538
RREYDEETVRWADAV

NADK2

141

Q4G0N4
VYREHVRCLEEWQEA

NLRP10

101

Q86W26
ASIAYDRHLWEVDVQ

ASL

26

P04424
GDSIRRDYEDLWNVV

DDX60L

386

Q5H9U9
RYEDRRAEWVTNEAG

PCSK7

441

Q16549
DFWEQEVRDIRSYLT

PCK2

601

Q16822
NAEEDVWVIIHLYRS

PDCL2

106

Q8N4E4
YEEIAQRSRAEAESW

KRT6B

341

P04259
AWIAADEEETYARVR

MTFR1L

66

Q9H019
VRRYDRNEITIWASE

GDPD3

166

Q7L5L3
VRAEDQVYDAAVRWL

KLHL7

201

Q8IXQ5
RRDAACVFWDNVVYI

KLHL7

326

Q8IXQ5
EAEAWYQCRYEELRV

KRT82

306

Q9NSB4
WEAAREAEQRRAYLE

HLA-B

171

P01889
ALDWVEVEAGRAIYR

PNPLA7

591

Q6ZV29
FAEDYQRVEDLAWHR

LMCD1

316

Q9NZU5
NVDREEHVYESIIRW

KBTBD8

206

Q8NFY9
AVAERRREELNGYIW

PIK3C2B

1441

O00750
ECLRSREVWLYEQVD

NCOA4

61

Q13772
EWEVVSVAEYHRRID

OXR1

651

Q8N573
KNDVTDGRAEYWVER

RGPD3

106

A6NKT7
LLAAYEQWRERADSA

DPYSL4

116

O14531
EQQRSDLWERLYVEA

CCPG1

441

Q9ULG6
NAIEAYDARADRWVN

KLHL10

306

Q6JEL2
YDARADRWVNVTCEE

KLHL10

311

Q6JEL2
VFEAALAWVRYDREQ

KLHL18

201

O94889
WVDEENILDVYRLAE

KLHL22

146

Q53GT1
RAVAAERQREQYWEE

CARD14

311

Q9BXL6
REERLEIQVWRAYGN

C2CD3

1486

Q4AC94
EIQVWRAYGNDSVER

C2CD3

1491

Q4AC94
VVADRRYLQQALDWF

FUT2

216

Q10981
EHWDAVYERELQTFR

EEF1AKMT2

36

Q5JPI9
NERYVFEAVIRWIAH

GAN

191

Q9H2C0
FRVLVYVVAAEEVWD

GJB4

31

Q9NTQ9
VIALDRYWAITDALE

HTR1D

131

P28221
LERYDAAFAQAREWE

CCDC57

71

Q2TAC2
ALQQELAWECDYRRE

COQ8B

276

Q96D53
NVRFIYEAWQGVERD

MCRIP1

36

C9JLW8
WFSSEELQEQLYVRR

CELSR3

1346

Q9NYQ7
DELDWVRVIDHSQYL

BTBD9

356

Q96Q07
FAAVLEWFAERVDRI

EHD1

171

Q9H4M9
ALWEAYREFESAIVE

SART3

226

Q15020
NDVLADYEARESWRQ

SCAPER

491

Q9BY12
RENAELESRIQEWYE

KRT36

116

O76013
AVWIFAAINRRDLYE

NLRP3

71

Q96P20
AQSLDEEAWRFLRYI

METTL24

121

Q5JXM2
WEVERAELQARIAFL

STRN3

86

Q13033
IAAYLLILWEEERAE

TRMT44

336

Q8IYL2
AVRAAYEAFCRWREV

ALDH5A1

101

P51649
LNVERFREWAVVLAD

SPRYD4

66

Q8WW59
YRVDERAAEQARWEA

PRKN

391

O60260
AWLYRAEVALREEIT

SYNE1

416

Q8NF91
EENVRNSFWIYDIVR

MKLN1

541

Q9UL63
YRDEYQRTWVAVVEE

MTCP1

21

P56278
RVFQEAVVDERQYIW

SMG7

376

Q92540
DAVVAARYQQVLAEW

SGSM2

596

O43147
RELLYEDVFAVWEVI

SGSM2

921

O43147
RAWVSLEELEEIQAY

SPDYE10

236

P0DUX0
RAWVSLEELEEIQAY

SPDYE11

236

P0DTA3
RAWVSLEELEEIQAY

SPDYE8

236

P0DUD1
VDGEWYRARVEKVES

SND1

741

Q7KZF4
FAAVLEWFAERVDRI

EHD3

171

Q9NZN3
VDAIYTRQEDVRFWL

OAF

166

Q86UD1
AYLIVDRDEAWVLET

SCRN1

156

Q12765
AVRDYASWAARVRQD

SPTBN5

1951

Q9NRC6
YIRRLAAEATEWQQA

SRPK3

226

Q9UPE1
VESVVRAHQWLYREI

CLCNKB

71

P51801
AFIFRVLAVWNRDEE

CLCN2

286

P51788
ALREQERVYEWFGLV

ZCCHC2

91

Q9C0B9
ADEWVRPEQAVVRYR

INPP5J

746

Q15735
RDVAIYFSREEWACL

ZNF707

11

Q96C28
RDVAIDFSRQEWEYL

ZNF573

31

Q86YE8
VQNHTREEELLWYRE

TMIGD1

56

Q6UXZ0
DEILEWESRVTQYER

SNX1

451

Q13596
RVLSIWEERSVYEND

RPRD1A

106

Q96P16
RAWVSLEELEEIQAY

SPDYE12

236

P0DUX1
RAWVSLEELEEIQAY

SPDYE13

236

A0A494C0Z2
RAWVSLEELEEIQAY

SPDYE14

236

P0DUD3
RAWVSLEELEEIQAY

SPDYE15

236

P0DUD4
RAWVSLEELEEIQAY

SPDYE17

236

P0DUD2
RDEWLEAISRAIEEY

FGD6

1171

Q6ZV73
REEVEATTVVEWFYR

SCN3B

51

Q9NY72
IERYEELAAELLAWI

SPTBN4

311

Q9H254
LSERWDAYCFRVQDV

STAB1

2291

Q9NY15
YRRAEQTFGELEVWA

PRPF40B

366

Q6NWY9
RAWVSREELEEIQAY

nan

261

A6NJR5
RAWVSLEELEEIQAY

SPDYE9

236

A0A494C191
RDVAVYFTQEEWRLL

ZNF875

36

P10072
EVDLADWQRNTVYRH

WWP1

806

Q9H0M0
EEEIDRAVYAWFLAL

TIGD5

121

Q53EQ6
LVIRDAQREDEAWYF

SIGLEC11

116

Q96RL6
DIIVADYDNRWVSIF

TRIM3

546

O75382