Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	diazepam binding	HTT GABRA6	6.56e-05	3	94	2	GO:0050809
Domain	ARM-type_fold	USP34 DOHH MIF4GD HSPBP1 IPO4 IPO9 XPO5 NBEAL2 IPO13 AP1G2 AP4B1 HTT	1.18e-07	339	93	12	IPR016024
Domain	ARM-like	DOHH HSPBP1 IPO4 IPO9 XPO5 NBEAL2 IPO13 AP1G2 AP4B1 HTT	9.50e-07	270	93	10	IPR011989
Domain	IBN_N	IPO4 IPO9 XPO5 IPO13	1.00e-06	16	93	4	SM00913
Domain	Importin-beta_N	IPO4 IPO9 XPO5 IPO13	1.30e-06	17	93	4	IPR001494
Domain	-	DOHH HSPBP1 IPO4 IPO9 XPO5 IPO13 AP1G2 AP4B1 HTT	1.63e-06	222	93	9	1.25.10.10
Domain	IMPORTIN_B_NT	IPO4 IPO9 IPO13	4.18e-05	14	93	3	PS50166
Domain	IBN_N	IPO4 IPO9 IPO13	5.21e-05	15	93	3	PF03810
Domain	HEAT	DOHH IPO4 IPO13 HTT	1.99e-04	58	93	4	IPR000357
Domain	TDE1/TMS	SERINC2 SERINC3	2.43e-04	5	93	2	IPR005016
Domain	Serinc	SERINC2 SERINC3	2.43e-04	5	93	2	PF03348
Domain	Xpo1	XPO5 IPO13	3.63e-04	6	93	2	PF08389
Domain	Exportin-1/Importin-b-like	XPO5 IPO13	3.63e-04	6	93	2	IPR013598
Domain	HEAT_REPEAT	DOHH IPO4 IPO13 HTT	4.11e-04	70	93	4	PS50077
Domain	Peripla_BP_I	GUCY2F TAS1R1 GRIN3A	9.59e-04	39	93	3	IPR028082
Domain	7TM_GPCR_Srsx	HTR6 SSTR1 CCKAR HCRTR1	2.37e-03	112	93	4	SM01381
Domain	Clathrin/coatomer_adapt-like_N	AP1G2 AP4B1	2.47e-03	15	93	2	IPR002553
Domain	Adaptin_N	AP1G2 AP4B1	2.47e-03	15	93	2	PF01602
Domain	CARD	NOD2 CARD6	2.81e-03	16	93	2	SM00114
Domain	HEAT_type_2	DOHH IPO4	3.18e-03	17	93	2	IPR021133
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	USP34 EP400 REV3L FHIP1B ST14 NOD2 KMT2C SLC38A10 AATK NBEAL2 AP1G2 DNMBP ABTB2 ZNF687 HTT AHNAK2	1.42e-07	1105	102	16	35748872
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	USP34 EP400 PITRM1 KMT2C TRANK1 NBEAL2 IPO13 ARHGAP20 KAT6B DNMBP ZNF687	4.66e-07	529	102	11	14621295
Pubmed	Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics.	RNF213 IPO4 IPO9 XPO5 NBEAL2 IPO13 AP1G2	1.21e-06	183	102	7	23956138
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	USP34 EPC2 RAE1 EP400 DIS3L RNF213 FASTKD5 REV3L FAM120A RTL9 MTR SFXN2 KAT6B ZNF687	4.87e-06	1116	102	14	31753913
Pubmed	Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.	FOXR1 SYNE1 HSPA12B KMT2C SCN9A CCDC33 ZNF292	5.95e-06	233	102	7	37704626
Pubmed	Suppressing aberrant GluN3A expression rescues synaptic and behavioral impairments in Huntington's disease models.	GRIN3A HTT	8.52e-06	2	102	2	23852340
Pubmed	Differential HspBP1 expression accounts for the greater vulnerability of neurons than astrocytes to misfolded proteins.	HSPBP1 HTT	8.52e-06	2	102	2	28847953
Pubmed	A high-throughput approach for measuring temporal changes in the interactome.	USP34 ABCF3 GBP1 UBA3 HSPBP1 IPO4 IPO9 XPO5 MTR PRKAR2A DNMBP DDX39B VARS1 HTT AHNAK2	2.23e-05	1455	102	15	22863883
Pubmed	Aggregate-centered redistribution of proteins by mutant huntingtin.	HSPBP1 HTT	2.55e-05	3	102	2	17208201
Pubmed	Expression and subcellular distribution of imp13 are regulated in brain development.	IPO9 IPO13	2.55e-05	3	102	2	23605716
Pubmed	Spontaneous 8bp Deletion in Nbeal2 Recapitulates the Gray Platelet Syndrome in Mice.	F5 NBEAL2	2.55e-05	3	102	2	26950939
Pubmed	The KBTBD6/7-DRD2 axis regulates pituitary adenoma sensitivity to dopamine agonist treatment.	KBTBD6 KBTBD7	2.55e-05	3	102	2	32572597
Pubmed	Sequential genome-wide CRISPR-Cas9 screens identify genes regulating cell-surface expression of tetraspanins.	USP34 RAE1 GBP1 NBEAL2 TAS1R1 TMEM150C GRIN3A NFAT5 DDX39B ABTB2 AHNAK2	3.39e-05	832	102	11	36724073
Pubmed	Large-scale identification of c-MYC-associated proteins using a combined TAP/MudPIT approach.	EP400 IPO4 GTF3C3 IPO9 XPO5 IPO13	3.85e-05	211	102	6	17314511
Pubmed	HAPSTR1 localizes HUWE1 to the nucleus to limit stress signaling pathways.	USP34 RAE1 IPO4 GTF3C3 XPO5 MTR PRKAR2A DDX39B VARS1	4.81e-05	571	102	9	37167062
Pubmed	The roles of multiple importins for nuclear import of murine aristaless-related homeobox protein.	IPO9 IPO13	5.09e-05	4	102	2	19494118
Pubmed	NOD-like receptor signaling and inflammasome-related pathways are highlighted in psoriatic epidermis.	NOD2 CARD6	5.09e-05	4	102	2	26976200
Pubmed	G908R NOD2 variant in a family with sarcoidosis.	NOD2 IL17RA	5.09e-05	4	102	2	29554915
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	USP34 SYNE1 KMT2C AATK XPO5 KAT6B	5.50e-05	225	102	6	12168954
Pubmed	Characterization of carbonic anhydrase IX interactome reveals proteins assisting its nuclear localization in hypoxic cells.	IPO4 IPO9 XPO5	6.06e-05	26	102	3	23181366
Pubmed	The cellular DExD/H-box RNA-helicases UAP56 and URH49 exhibit a CRM1-independent nucleocytoplasmic shuttling activity.	RAE1 DDX39B	8.47e-05	5	102	2	21799930
Pubmed	Prognostic significance of folate metabolism polymorphisms for lung cancer.	MTR TRDMT1	8.47e-05	5	102	2	17533396
Pubmed	Tlx1/3 and Ptf1a control the expression of distinct sets of transmitter and peptide receptor genes in the developing dorsal spinal cord.	SSTR1 CCKAR GRIN3A GABRA6	9.75e-05	81	102	4	22723691
Pubmed	Predictive role of coagulation-balance gene polymorphisms in the efficacy of photodynamic therapy with verteporfin for classic choroidal neovascularization secondary to age-related macular degeneration.	F5 MTR	1.27e-04	6	102	2	18004208
Pubmed	Coagulation gene predictors of photodynamic therapy for occult choroidal neovascularization in age-related macular degeneration.	F5 MTR	1.27e-04	6	102	2	18378576
Pubmed	The p97/VCP segregase is essential for arsenic-induced degradation of PML and PML-RARA.	USP34 RNF213 GTF3C3 FAM120A SFXN2 ZNF687	1.27e-04	262	102	6	36880596
Pubmed	A Myc network accounts for similarities between embryonic stem and cancer cell transcription programs.	EPC2 RAE1 EP400	1.50e-04	35	102	3	20946988
Pubmed	Regulation of Wnt/PCP signaling through p97/VCP-KBTBD7-mediated Vangl ubiquitination and endoplasmic reticulum-associated degradation.	KBTBD6 KBTBD7	1.77e-04	7	102	2	33990333
Pubmed	The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells.	USP34 RAE1 EP400 IPO4 XPO5 ZNF687	1.89e-04	282	102	6	23667531
Pubmed	Association study of 182 candidate genes in anorexia nervosa.	HTR6 CCKAR TAS1R1 HCRTR1 GABRA6	2.05e-04	182	102	5	20468064
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	EPC2 FOXR1 ABCF3 EP400 REV3L KBTBD7 GTF3C3 FAM120A PRDM6 VARS1	2.16e-04	857	102	10	25609649
Pubmed	Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	USP34 SYNE1 SERINC2 IPO13	2.29e-04	101	102	4	9872452
Pubmed	Importins fulfil a dual function as nuclear import receptors and cytoplasmic chaperones for exposed basic domains.	IPO4 IPO9	2.36e-04	8	102	2	11823430
Pubmed	Importin 8 mediates m7G cap-sensitive nuclear import of the eukaryotic translation initiation factor eIF4E.	IPO4 IPO9	2.36e-04	8	102	2	27114554
Pubmed	Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.	HTR6 SSTR1 CCKAR GRIN3A HCRTR1 GABRA6	2.64e-04	300	102	6	19086053
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	PITRM1 SYNE1 FASTKD5 HSPBP1 IPO4 GTF3C3 IPO9 FAM120A XPO5 MTR PRKAR2A DDX39B VARS1	2.74e-04	1425	102	13	30948266
Pubmed	A novel p53 regulator, C16ORF72/TAPR1, buffers against telomerase inhibition.	RAE1 DIS3L SERINC2 IPO4 KBTBD7 MTR ABTB2	2.87e-04	431	102	7	33660365
Pubmed	The protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1.	PITRM1 SYNE1 REV3L F5 ARHGAP20	2.96e-04	197	102	5	20811636
Pubmed	A Dynamic Splicing Program Ensures Proper Synaptic Connections in the Developing Cerebellum.	EPC2 AP1G2 NFAT5	2.97e-04	44	102	3	32492419
Pubmed	Tumor-derived neomorphic mutations in ASXL1 impairs the BAP1-ASXL1-FOXK1/K2 transcription network.	FASTKD5 IPO9 XPO5 VARS1	3.28e-04	111	102	4	32683582
Pubmed	The human ATP-binding cassette (ABC) transporter superfamily.	ABCF3 ABCG4	3.77e-04	10	102	2	11435397
Pubmed	Cytoplasmic Metadherin (MTDH) provides survival advantage under conditions of stress by acting as RNA-binding protein.	SYNE1 RNF213 SLC22A18AS IPO9 IL17RA	4.32e-04	214	102	5	22199357
Pubmed	Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.	EP400 RNF213 XPO5 DDX39B VARS1 AHNAK2	4.52e-04	332	102	6	32786267
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	RAE1 FASTKD5 HSPBP1 IPO4 GTF3C3 IPO9 XPO5 MTR PRKAR2A VARS1	4.56e-04	942	102	10	31073040
Pubmed	N6-Methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation.	KMT2C SLC38A10 IPO9 CRISPLD1 ZNF292	4.60e-04	217	102	5	34048709
Pubmed	CUL3-KBTBD6/KBTBD7 ubiquitin ligase cooperates with GABARAP proteins to spatially restrict TIAM1-RAC1 signaling.	KBTBD6 KBTBD7	4.60e-04	11	102	2	25684205
Pubmed	METTL3 protects METTL14 from STUB1-mediated degradation to maintain m6 A homeostasis.	HPSE2 HSPBP1 SLC38A10 PRKAR2A VARS1	6.11e-04	231	102	5	36597993
Pubmed	Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes.	EPC2 RAE1 EP400 KBTBD6 HSPBP1 F5 IPO9 ZNF687	6.37e-04	645	102	8	25281560
Pubmed	The FTS-Hook-FHIP (FHF) complex interacts with AP-4 to mediate perinuclear distribution of AP-4 and its cargo ATG9A.	FHIP1B AP4B1	6.50e-04	13	102	2	32073997
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	KMT2C TRANK1 LOXHD1 NBEAL2 SCN9A ZNF687 ZNF292	6.70e-04	497	102	7	36774506
Pubmed	Cold-inducible RBM3 inhibits PERK phosphorylation through cooperation with NF90 to protect cells from endoplasmic reticulum stress.	USP34 FAM120A AP1G2	7.42e-04	60	102	3	26472337
Pubmed	Epithelial expression of Gata4 and Sox2 regulates specification of the squamous-columnar junction via MAPK/ERK signaling in mice.	SYNE1 CCKAR	9.95e-04	16	102	2	33495473
Pubmed	Systematic protein-protein interaction mapping for clinically relevant human GPCRs.	RAE1 HTR6 SYNE1 AATK IPO13 SERINC3 MFSD3 HTT	1.05e-03	697	102	8	28298427
Pubmed	USP7 Cooperates with NOTCH1 to Drive the Oncogenic Transcriptional Program in T-Cell Leukemia.	RAE1 XPO5 VARS1	1.31e-03	73	102	3	30224337
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	ABCF3 DIS3L FAM120A DNMBP DDX39B VARS1 AHNAK2 ZNF292	1.34e-03	724	102	8	36232890
Pubmed	Large-scale mapping of human protein-protein interactions by mass spectrometry.	UBA3 IPO4 GTF3C3 KMT2C LOXHD1 IPO9 XPO5 MTR SERINC3 AP4B1 VARS1	1.38e-03	1284	102	11	17353931
Pubmed	Purification and Transcriptomic Analysis of Mouse Fetal Leydig Cells Reveals Candidate Genes for Specification of Gonadal Steroidogenic Cells.	TRANK1 ADAMTS16	1.41e-03	19	102	2	25855264
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	USP34 EP400 RNF213 FASTKD5 FAM120A MTR VARS1 ZNF687	1.44e-03	733	102	8	34672954
Pubmed	Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.	DLGAP2 ABL2 SYNE1 PITPNM1 PRKAR2A	1.46e-03	281	102	5	28706196
Pubmed	Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease.	MTR TRDMT1	1.56e-03	20	102	2	23824729
Pubmed	FBXW7 modulates cellular stress response and metastatic potential through HSF1 post-translational modification.	RAE1 EP400 IPO4	1.59e-03	78	102	3	25720964
Pubmed	BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.	DOHH RAE1 EP400 FASTKD5 IPO4 IPO9 FAM120A XPO5 DDX39B VARS1 ZNF687	1.69e-03	1318	102	11	30463901
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	USP34 RAE1 EP400 IPO4 DDX11 MTR DNMBP	1.76e-03	588	102	7	38580884
Pubmed	A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.	RAE1 PITRM1 FASTKD5 PRKAR2A IL17RA	1.89e-03	298	102	5	32353859
Pubmed	MRG15 binds directly to PALB2 and stimulates homology-directed repair of chromosomal breaks.	EPC2 EP400	2.07e-03	23	102	2	20332121
Pubmed	CATACOMB: An endogenous inducible gene that antagonizes H3K27 methylation activity of Polycomb repressive complex 2 via an H3K27M-like mechanism.	EPC2 EP400	2.07e-03	23	102	2	31281901
Pubmed	A functional cellular framework for sex and estrous cycle-dependent gene expression and behavior.	CCKAR ABTB2	2.07e-03	23	102	2	35065713
Pubmed	Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans.	EPC2 EP400	2.07e-03	23	102	2	14966270
Pubmed	Targeting RICTOR Sensitizes SMAD4-Negative Colon Cancer to Irinotecan.	ST14 SLC38A10 MTR DNMBP	2.11e-03	183	102	4	31932471
Pubmed	Dimerization quality control ensures neuronal development and survival.	KBTBD6 KBTBD7	2.25e-03	24	102	2	30190310
Pubmed	Global landscape of HIV-human protein complexes.	DOHH RNF213 IPO4 IPO9 XPO5 NFAT5	2.32e-03	457	102	6	22190034
Pubmed	Transcriptome analysis in blastocyst hatching by cDNA microarray.	PITRM1 TRDMT1	2.45e-03	25	102	2	15919778
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	EP400 GTF3C3 KMT2C FAM120A RTL9 CRISPLD1	2.64e-03	469	102	6	27634302
Pubmed	Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons.	USP34 IPO4 KMT2C IPO9 VARS1	2.64e-03	322	102	5	26514267
Pubmed	Localization of somatostatin receptor genes on mouse chromosomes 2, 11, 12, 15, and 17: correlation with growth QTLs.	SSTR1 GABRA6	2.64e-03	26	102	2	9226367
Pubmed	Quantitative interaction proteomics of neurodegenerative disease proteins.	RAE1 IPO4 IPO9 PRKAR2A HTT	2.68e-03	323	102	5	25959826
Pubmed	Agrin has a pathological role in the progression of oral cancer.	SYNE1 IPO4 IPO9 PRKAR2A	2.75e-03	197	102	4	29872149
Pubmed	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.	IPO4 GTF3C3 IPO9 XPO5 PRKAR2A DDX39B VARS1	2.78e-03	638	102	7	33239621
Pubmed	Replication of a genome-wide case-control study of esophageal squamous cell carcinoma.	SYNE1 GRIN3A	2.85e-03	27	102	2	18649358
GeneFamily	Armadillo repeat containing\|Importins	IPO4 IPO9 IPO13	4.54e-05	18	71	3	596
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANO2 TRANK1 LOXHD1 GUCY2F OTOGL SCN9A ADAMTS16	2.12e-07	184	101	7	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANO2 TRANK1 LOXHD1 GUCY2F OTOGL SCN9A ADAMTS16	2.12e-07	184	101	7	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANO2 TRANK1 LOXHD1 GUCY2F OTOGL SCN9A ADAMTS16	2.12e-07	184	101	7	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	facs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	GBP1 HPSE2 F5 GUCY2F OTOGL SCN9A	1.90e-06	162	101	6	bf886e22ff2a20353499004b53f25fb9e6574896
ToppCell	Calu_3-infected\|Calu_3 / Cell line, Condition and Strain	GBP1 RNF213 KMT2C TRANK1 NFAT5 ZNF292	3.84e-06	183	101	6	8f7f5000645f24f20a8d7700c4df1f8953a1780b
ToppCell	Smart-seq2-bone_marrow_(Smart-seq2)-myeloid-myeloid_granulocytic-neutrophil\|bone_marrow_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	KBTBD6 SYNE1 KBTBD7 LOXHD1 NBEAL2 IL17RA	4.91e-06	191	101	6	d4f77c73311d1149466bbfe4adbd6a301946ec90
ToppCell	severe-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	USP34 SYNE1 RNF213 KMT2C DDX39B ZNF292	5.86e-06	197	101	6	57ebd552f10d6278623b52a3d484d4b91ae1d028
ToppCell	facs-Marrow-B-cells-3m-Myeloid-granulocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DLGAP2 HPSE2 TRANK1 SCN9A ADAMTS16	1.52e-05	137	101	5	4dcb15de821439011df1bb0bbd7682d674bd725d
ToppCell	facs-Marrow-B-cells-3m-Myeloid-granulocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DLGAP2 HPSE2 TRANK1 SCN9A ADAMTS16	1.52e-05	137	101	5	c05ceeb7b483324604cb3f647d2da2b3786071b1
ToppCell	facs-Trachea-18m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l20-23\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	GBP1 TRANK1 SCN9A GRIN3A CCDC33	1.94e-05	144	101	5	e9d62f202f0fa8747961036ef0eafed91fe8a42f
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Degenerative_Fibroblast-Degenerative_Fibroblast_119\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	DLGAP2 CCDC168 PITPNM1 SERINC3 SPOCD1	3.72e-05	165	101	5	cca3ba9d7d30404e3e683b8cfd500c348a4974b9
Drug	Artemisinin [63968-64-9]; Up 200; 14.2uM; HL60; HG-U133A	USP34 ST14 SLC38A10 NBEAL2 PRKAR2A KAT6B NFAT5 HTT TRDMT1	2.09e-07	200	98	9	1714_UP
Disease	response to erlotinib	NFAT5 HCRTR1	6.13e-05	4	95	2	EFO_0007868
Disease	Schizophrenia	DLGAP2 HTR6 FASTKD5 CCKAR PITPNM1 HCAR3 MTR GRIN3A HCRTR1 GABRA6	5.58e-04	883	95	10	C0036341
Disease	Bipolar Disorder	SYNE1 CCKAR NOD2 HCAR3 TRANK1 MTR GRIN3A	8.98e-04	477	95	7	C0005586
Disease	breast cancer (is_implicated_in)	F5 NOD2 XPO5 KAT6B	1.43e-03	150	95	4	DOID:1612 (is_implicated_in)
Disease	migraine disorder, systolic blood pressure	RNF213 HPSE2	1.52e-03	18	95	2	EFO_0006335, MONDO_0005277
Disease	Mood Disorders	HTR6 HCRTR1 HTT GABRA6	2.16e-03	168	95	4	C0525045
Disease	Acute kidney injury	GBP1 DISP1	2.93e-03	25	95	2	HP_0001919
Disease	intestinal permeability measurement	AATK GRIN3A	3.17e-03	26	95	2	EFO_0011031

Protein segments in the cluster

Peptide	Gene	Start	Entry
ERMDAMLLRQCPTQG	FAM223B	46	A6NKX1
PASPEMAQMRKQCLD	EP400	356	Q96L91
CVSINRAVPQMPTGM	EPC2	31	Q52LR7
NPMLFRAVQNGLCAM	ABCG4	321	Q9H172
CNSTMNPIIYPLFMR	HTR6	311	P50406
MMNFDVPRVSQNGCP	CCDC33	441	Q8N5R6
LPEQDRMAMTLPRNC	ABL2	791	P42684
RPVCRKFMQDPMEIF	DDX39B	236	Q13838
KSRVAFAQMTMPCPN	ABCF3	616	Q9NUQ8
AMMQELQAFLESCPP	AP1G2	381	O75843
DPNPMVRGLALRSMC	AP4B1	96	Q9Y6B7
LCQQNMDPSAMPRPT	DLGAP2	926	Q9P1A6
CIERIMVPMQQAQVP	DNMBP	806	Q6XZF7
CRNLPMISFLILPMQ	ARHGEF26	566	Q96DR7
MPQPVLKAMRCAEGA	SLC22A18AS	96	Q8N1D0
QTANMCRFLLPNDVM	CCKAR	191	P32238
IPSREMCDQQNAFTM	ANO2	396	Q9NQ90
CQMPNMEANVPAVLT	DISP1	1496	Q96F81
CLGQMQDARAIPMLV	DOHH	61	Q9BU89
DPNVACRRLMTPIMY	ASZ1	141	Q8WWH4
MLLAQVAEQAPACAM	ADAMTS16	16	Q8TE57
SNPMMVLQLPERCYC	RAE1	161	P78406
LAQCSMAANFTPPMQ	KAT6B	1766	Q8WYB5
SPCMLVALRPTNMDR	KIAA0895L	136	Q68EN5
QTPVMADPETCLMVF	FHIP1B	26	Q8N612
AICNPLRYQMIMTPR	OR6K3	141	Q8NGY3
AAMNMILPDFKRPAC	IL17RA	481	Q96F46
ASMPSRQPMLLFLCQ	OR10AC1	51	Q8NH08
RIKQQQQCAMAPPTM	KMT2C	3266	Q8NEZ4
CRDLLASFNPMDMPR	LOXHD1	156	Q8IVV2
LIEELSAMIPQCNPM	ARNTL2	126	Q8WYA1
SAMIPQCNPMARKLD	ARNTL2	131	Q8WYA1
MRRPGMLCSFQIPDA	DCAF4L2	171	Q8NA75
NSLIMAPQTLMLPRC	OR2W6P	161	Q8NHA6
MCLIENTNGRLMANP	GBP1	11	P32455
TINADCPMRLVNFPM	GABRA6	151	Q16445
FLACMRSDTPAMLNP	FAM120A	691	Q9NZB2
AENPPQRLGMCAKEM	KBTBD7	331	Q8WVZ9
RCVVMVGMPFPNIRS	DDX11	791	Q96FC9
LRMSCEAMNELFQPT	HSPA12B	446	Q96MM6
MRVLCAFPEAMPSSN	HPSE2	1	Q8WWQ2
TGMMRCSQLAPRALQ	MFSD3	341	Q96ES6
EDMQMQCELFSSPPA	NFAT5	946	O94916
IQPELALIPSTMNCM	GRIN3A	406	Q8TCU5
VMEAMCRQDALQPFN	PRDM6	391	Q9NQX0
MVPQAAVMECSSVLP	HCRTR1	176	O43613
FSREPMMATVCVQQL	HTT	1301	P42858
PAACMQTPRMKLAVQ	FASTKD5	686	Q7L8L6
VQACPERPQMMGTLE	CARD6	826	Q9BX69
FMARAIPAMVVPNAT	CRISPLD1	16	Q9H336
IPFSEAQMCEMPVNT	DIS3L	436	Q8TF46
RGTPFCMMDLPAQEI	GUCY2F	746	P51841
IQQCMSQPDVMPFLF	FOXR1	276	Q6PIV2
IEACQGPMQMRLIPT	IPO9	636	Q96P70
VMDVQAFERLLGPCM	PRKAR2A	361	P13861
MQQLPSRCPSQPIMN	KIAA1210	906	Q9ULL0
QTILENSPCPMMDPF	CCDC168	966	Q8NDH2
VAVGFPMMILPCRQA	SLC38A10	281	Q9HBR0
LLDDFAPMVPQLCEM	IPO13	716	O94829
MECMLQLLRNPSSPR	IPO4	481	Q8TEX9
CPTPFMVGVQMRFQQ	DENND2D	301	Q9H6A0
AENPPQRLGMCAKEM	KBTBD6	331	Q86V97
PMMALVNPVYDCLFR	MIF4GD	121	A9UHW6
LCPMPLLNCAEDMNL	OTOGL	2046	Q3ZCN5
EQMKSCLRVLSQPMP	HSPBP1	91	Q9NZL4
QEPFLMEQLPREMQC	ARHGAP20	291	Q9P2F6
PQNKQMAFCRPMTET	RTL9	21	Q8NET4
PNVSAANPRGVFMMC	VARS1	326	P26640
VACNMLMPEPAQRWL	SSTR1	206	P30872
DRLSFDMILMSPPCQ	TRDMT1	66	O14717
FAAVAAANCVNIPMM	SFXN2	181	Q96NB2
PPLMQEITAMQDRCL	SYNE1	5291	Q8NF91
MQTPFLIMDRDCRMP	F5	1896	P12259
ESMAPDPRTLQRMAC	AATK	221	Q6ZMQ8
QNPPCPRLNSMLMEV	NBPF26	816	B4DH59
GDIPCRLVLFMFAMN	HCAR3	96	P49019
IPMMLACEDRPVLQA	NBEAL2	311	Q6ZNJ1
MLDGPSAMTRFCNLI	MTR	421	Q99707
DNMRCSVNATPQQMP	PITRM1	776	Q5JRX3
ILTNCIFMTMNNPPD	SCN9A	136	Q15858
DPPASCVFSQVMNMA	TMEM150C	61	B9EJG8
RFGMSSCPQVPMEER	ODF3L1	96	Q8IXM7
MCMEIIRQAPLAYEP	GTF3C3	171	Q9Y5Q9
LRCPQMESMENPNLD	ABTB2	391	Q8N961
LQQVSACSEPSMQMP	AHNAK2	4746	Q8IVF2
VLRMVPCMVVGTQNP	SLC49A3	111	Q6UXD7
LANMVQIIRQMCPTP	TRIM52	201	Q96A61
MPALEAAQMRPACEQ	PITPNM1	711	O00562
IMEQSMRCLPAFLPD	RNF213	1781	Q63HN8
QVNFPMCTIASMPRL	UBA3	231	Q8TBC4
MPMIQRTSEPLNCDY	SIRPB2	96	Q5JXA9
PFSAQVGDERMQCLM	TAS1R1	246	Q7RTX1
GNSPMARLLPTMCIQ	NOD2	636	Q9HC29
VLSPEMLQCTPANMV	REV3L	341	O60673
RSQMRAPQCVPLIME	REV3L	2586	O60673
PLELINMTEDCMPLN	SAGE2P	456	A6NJ88
MFMDCSPQALPIASE	SPOCD1	761	Q6ZMY3
CENLLPQQITPRMMC	ST14	776	Q9Y5Y6
PQQITPRMMCVGFLS	ST14	781	Q9Y5Y6
MLCSQMENLPSTALP	ZNF292	1226	O60281
MCRDYPQLVLPNFDM	XPO5	611	Q9HAV4
AMSNEPDRSCNPNLM	SERINC3	286	Q13530
MEARSMLVPPQASVC	ZNF544	1	Q6NX49
PMMLPNRCSFSAHQR	ZNF687	711	Q8N1G0
LPTCPNMLMAFQNIS	USP34	1401	Q70CQ2
RLQLMSMDCPGQVPE	TRANK1	2551	O15050
RPFLLNNCAVQSMEM	ZNF772	206	Q68DY9
QVNSLMQTEECPPML	SERINC2	346	Q96SA4