Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	glycogen phosphorylase activity	PYGB PYGL	1.99e-05	3	52	2	GO:0008184
GeneOntologyMolecularFunction	1,4-alpha-oligoglucan phosphorylase activity	PYGB PYGL	6.62e-05	5	52	2	GO:0004645
GeneOntologyMolecularFunction	actin filament binding	SPTBN4 EPS8L2 SPTA1 MACF1 EPS8L1	3.06e-04	227	52	5	GO:0051015
GeneOntologyBiologicalProcess	glycogen catabolic process	PYGB PYGL PGM2	9.34e-05	35	52	3	GO:0005980
GeneOntologyBiologicalProcess	glucan catabolic process	PYGB PYGL PGM2	1.02e-04	36	52	3	GO:0009251
GeneOntologyBiologicalProcess	polysaccharide catabolic process	PYGB PYGL PGM2	1.20e-04	38	52	3	GO:0000272
GeneOntologyBiologicalProcess	protein deubiquitination involved in ubiquitin-dependent protein catabolic process	USP28 OTUD7A	1.73e-04	8	52	2	GO:0071947
GeneOntologyCellularComponent	ruffle membrane	EPS8L2 MACF1 EPS8L1 C2CD5	1.40e-04	108	51	4	GO:0032587
GeneOntologyCellularComponent	spectrin	SPTBN4 SPTA1	2.08e-04	9	51	2	GO:0008091
GeneOntologyCellularComponent	inner dynein arm	DNAH12 DNAH2	2.59e-04	10	51	2	GO:0036156
GeneOntologyCellularComponent	cell cortex	SPTBN4 FRY SPTA1 MACF1 BIN2 C2CD5	2.76e-04	371	51	6	GO:0005938
Domain	Spectrin	SPTBN4 SPTA1 MACF1 UTRN	4.55e-07	23	52	4	PF00435
Domain	Spectrin_repeat	SPTBN4 SPTA1 MACF1 UTRN	1.21e-06	29	52	4	IPR002017
Domain	Spectrin/alpha-actinin	SPTBN4 SPTA1 MACF1 UTRN	1.81e-06	32	52	4	IPR018159
Domain	SPEC	SPTBN4 SPTA1 MACF1 UTRN	1.81e-06	32	52	4	SM00150
Domain	PHOSPHORYLASE	PYGB PYGL	2.28e-05	3	52	2	PS00102
Domain	Phosphorylase	PYGB PYGL	2.28e-05	3	52	2	PF00343
Domain	Glycg_phsphrylas	PYGB PYGL	2.28e-05	3	52	2	IPR011833
Domain	Glyco_trans_35	PYGB PYGL	2.28e-05	3	52	2	IPR000811
Domain	Actinin_actin-bd_CS	SPTBN4 MACF1 UTRN	3.47e-05	23	52	3	IPR001589
Domain	ACTININ_2	SPTBN4 MACF1 UTRN	3.47e-05	23	52	3	PS00020
Domain	ACTININ_1	SPTBN4 MACF1 UTRN	3.47e-05	23	52	3	PS00019
Domain	EPS8_PTB	EPS8L2 EPS8L1	4.55e-05	4	52	2	IPR033928
Domain	PTB	EPS8L2 EPS8L1	2.11e-04	8	52	2	PF08416
Domain	PTB	EPS8L2 EPS8L1	2.11e-04	8	52	2	IPR013625
Domain	SH3	EPS8L2 SPTA1 MACF1 EPS8L1 TP53BP2	3.30e-04	216	52	5	PS50002
Domain	SH3_domain	EPS8L2 SPTA1 MACF1 EPS8L1 TP53BP2	3.59e-04	220	52	5	IPR001452
Domain	Dynein_heavy_chain_D4_dom	DNAH12 DNAH2	6.77e-04	14	52	2	IPR024317
Domain	Dynein_heavy_dom-2	DNAH12 DNAH2	6.77e-04	14	52	2	IPR013602
Domain	DHC_N2	DNAH12 DNAH2	6.77e-04	14	52	2	PF08393
Domain	AAA_8	DNAH12 DNAH2	6.77e-04	14	52	2	PF12780
Domain	ATPase_dyneun-rel_AAA	DNAH12 DNAH2	6.77e-04	14	52	2	IPR011704
Domain	AAA_5	DNAH12 DNAH2	6.77e-04	14	52	2	PF07728
Domain	-	TCHH SPTA1 MACF1 UTRN TBC1D9	7.80e-04	261	52	5	1.10.238.10
Domain	Spectrin_alpha_SH3	SPTA1 TP53BP2	7.80e-04	15	52	2	IPR013315
Domain	DHC_fam	DNAH12 DNAH2	7.80e-04	15	52	2	IPR026983
Domain	Dynein_heavy_dom	DNAH12 DNAH2	7.80e-04	15	52	2	IPR004273
Domain	Dynein_heavy	DNAH12 DNAH2	7.80e-04	15	52	2	PF03028
Domain	CH	SPTBN4 MACF1 UTRN	7.87e-04	65	52	3	SM00033
Domain	CH	SPTBN4 MACF1 UTRN	9.77e-04	70	52	3	PF00307
Domain	-	SPTBN4 MACF1 UTRN	1.02e-03	71	52	3	1.10.418.10
Domain	CH	SPTBN4 MACF1 UTRN	1.10e-03	73	52	3	PS50021
Domain	SH3_1	EPS8L2 SPTA1 EPS8L1 TP53BP2	1.12e-03	164	52	4	PF00018
Domain	EF-hand-dom_pair	TCHH SPTA1 MACF1 UTRN TBC1D9	1.19e-03	287	52	5	IPR011992
Domain	CH-domain	SPTBN4 MACF1 UTRN	1.19e-03	75	52	3	IPR001715
Domain	SH3	EPS8L2 SPTA1 EPS8L1 TP53BP2	3.05e-03	216	52	4	SM00326
Domain	EF_HAND_2	TCHH SPTA1 MACF1 TBC1D9	3.88e-03	231	52	4	PS50222
Domain	EF_hand_dom	TCHH SPTA1 MACF1 TBC1D9	3.94e-03	232	52	4	IPR002048
Domain	PTB	EPS8L2 EPS8L1	5.54e-03	40	52	2	SM00462
Domain	PTB/PI_dom	EPS8L2 EPS8L1	5.82e-03	41	52	2	IPR006020
Domain	TBC	EVI5 TBC1D9	8.22e-03	49	52	2	SM00164
Domain	RabGAP-TBC	EVI5 TBC1D9	9.57e-03	53	52	2	PF00566
Domain	TBC_RABGAP	EVI5 TBC1D9	1.03e-02	55	52	2	PS50086
Domain	Rab-GTPase-TBC_dom	EVI5 TBC1D9	1.03e-02	55	52	2	IPR000195
Pathway	KEGG_MEDICUS_REFERENCE_GLYCOGEN_DEGRADATION	PYGB PYGL PGM2	2.19e-06	9	43	3	M47621
Pubmed	The PHLPP1 N-Terminal Extension Is a Mitotic Cdk1 Substrate and Controls an Interactome Switch.	SF3B1 POLH EIF4G2 NUP214 ATP1A1 KNL1	3.58e-06	256	56	6	33397691
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	BPTF SF3B1 PYGB MACF1 PYGL NUP214 ATP1A1 UTRN	9.50e-06	653	56	8	22586326
Pubmed	A novel role for the peptidyl-prolyl cis-trans isomerase Cyclophilin A in DNA-repair following replication fork stalling via the MRE11-RAD50-NBS1 complex.	BPTF EPS8L2 USP28 POLH MACF1 TP53BP2 KNL1	1.06e-05	472	56	7	38943005
Pubmed	Characterising the dynamics of placental glycogen stores in the mouse.	PYGB PYGL PGM2	1.40e-05	29	56	3	32798765
Pubmed	In silico analysis of the EPS8 gene family: genomic organization, expression profile, and protein structure.	EPS8L2 EPS8L1	1.52e-05	4	56	2	12620401
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	SF3B1 USP28 EIF4G2 MACF1 NUP214 ATP1A1 UTRN TP53BP2 KNL1	1.71e-05	934	56	9	33916271
Pubmed	Host E3 ligase HUWE1 attenuates the proapoptotic activity of the MERS-CoV accessory protein ORF3 by promoting its ubiquitin-dependent degradation.	TMX1 SF3B1 MAGED4 CD2BP2 EIF4G2 PYGB NUP214	2.34e-05	534	56	7	35032548
Pubmed	E-cadherin interactome complexity and robustness resolved by quantitative proteomics.	EPS8L2 EIF4G2 MACF1 NUP214 EPS8L1 UTRN TP53BP2	3.35e-05	565	56	7	25468996
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	SPTBN4 FRY TARS3 SF3B1 DROSHA USP28 MORF4L1 EIF4G2 MACF1 UTRN	3.47e-05	1285	56	10	35914814
Pubmed	Large-scale cDNA transfection screening for genes related to cancer development and progression.	GDPD5 EPS8L2 MORF4L1 EPS8L1	3.53e-05	114	56	4	15498874
Pubmed	Eps8 controls actin-based motility by capping the barbed ends of actin filaments.	EPS8L2 EPS8L1	3.80e-05	6	56	2	15558031
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	DROSHA USP28 CD2BP2 PYGB MACF1 ATP1A1 KNL1	4.31e-05	588	56	7	38580884
Pubmed	Functional proteomics mapping of a human signaling pathway.	SF3B1 DROSHA EIF4G2 MACF1 UTRN TP53BP2 KNL1	4.45e-05	591	56	7	15231748
Pubmed	Human Immunodeficiency Virus Type 1 Vpr Mediates Degradation of APC1, a Scaffolding Component of the Anaphase-Promoting Complex/Cyclosome.	WDR74 DROSHA MORF4L1 NUP214 KNL1	4.48e-05	242	56	5	34011540
Pubmed	Isolation of several human axonemal dynein heavy chain genes: genomic structure of the catalytic site, phylogenetic analysis and chromosomal assignment.	DNAH12 DNAH2	5.32e-05	7	56	2	9256245
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	BPTF SPAM1 TCHH DROSHA ZNF212 MORF4L1 MACF1 C2CD5 KNL1	6.82e-05	1116	56	9	31753913
Pubmed	The eps8 family of proteins links growth factor stimulation to actin reorganization generating functional redundancy in the Ras/Rac pathway.	EPS8L2 EPS8L1	7.09e-05	8	56	2	14565974
Pubmed	Genes encoding alpha and beta subunits of Na,K-ATPase are located on three different chromosomes in the mouse.	SPTA1 ATP1A1	7.09e-05	8	56	2	2885848
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	SPTBN4 TARS3 SF3B1 SPTA1 EIF4G2 PYGB MACF1 ATP1A1 UTRN TP53BP2	8.53e-05	1431	56	10	37142655
Pubmed	Discovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome Stability.	USP28 OTUD7A UTRN C2CD5	9.48e-05	147	56	4	29576527
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	DROSHA MORF4L1 EIF4G2 MACF1 ATP1A1 UTRN	1.47e-04	497	56	6	23414517
Pubmed	MYC multimers shield stalled replication forks from RNA polymerase.	WDR74 BPTF SF3B1 USP28 MORF4L1 CD2BP2 ATP1A1 KNL1	1.76e-04	989	56	8	36424410
Pubmed	TIF1γ inhibits lung adenocarcinoma EMT and metastasis by interacting with the TAF15/TBP complex.	BPTF SF3B1 PYGL ATP1A1	2.02e-04	179	56	4	36261009
Pubmed	Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.	TMX1 BPTF EPS8L2 SF3B1 MORF4L1 MACF1 NUP214 ATP1A1 PGM2	2.12e-04	1297	56	9	33545068
Pubmed	Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene.	DNAH12 DNAH2	2.29e-04	14	56	2	9373155
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	TMX1 BPTF SF3B1 EIF4G2 NUP214 TBC1D9 C2CD5	2.37e-04	774	56	7	15302935
Pubmed	Engagement of the G3BP2-TRIM25 Interaction by Nucleocapsid Protein Suppresses the Type I Interferon Response in SARS-CoV-2-Infected Cells.	EVI5 TCHH DNAH12	2.56e-04	76	56	3	36560452
Pubmed	Localization of the muscle, liver, and brain glycogen phosphorylase genes on linkage maps of mouse chromosomes 19, 12, and 2, respectively.	PYGB PYGL	2.64e-04	15	56	2	2575583
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	WDR74 SF3B1 EIF4G2 PYGB MACF1 PYGL NUP214 UTRN TP53BP2	2.89e-04	1353	56	9	29467282
Pubmed	Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q13.3 microdeletion syndrome.	EVI5 OTUD7A MACF1 ATPAF2	2.91e-04	197	56	4	36604605
Pubmed	Transcriptome analysis of mouse stem cells and early embryos.	BPTF EIF4G2 IFFO2 BIN2 UTRN	2.97e-04	363	56	5	14691545
Pubmed	Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells.	TMX1 SF3B1 EIF4G2 PYGB PYGL NUP214 ATP1A1 UTRN KNL1	3.12e-04	1367	56	9	32687490
Pubmed	Mapping the mammalian ribosome quality control complex interactome using proximity labeling approaches.	EIF4G2 NUP214 PGM2 C2CD5	3.20e-04	202	56	4	29540532
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	WDR74 BPTF MORF4L1 EIF4G2 PYGL BIN2 ATP1A1 KNL1	3.67e-04	1103	56	8	34189442
Pubmed	Organization of focal adhesion plaques is disrupted by action of the HIV-1 protease.	SPTBN4 SPTA1	3.83e-04	18	56	2	12119179
Pubmed	Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage.	TCHH SF3B1 EIF4G2 PYGB MACF1 PYGL UTRN	3.99e-04	844	56	7	25963833
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	SPTBN4 BPTF SF3B1 FAM186A SPTA1 DNAH2 MACF1 ATP1A1 ATPAF2	4.61e-04	1442	56	9	35575683
Pubmed	Analysis of interaction partners for eukaryotic translation elongation factor 1A M-domain by functional proteomics.	EIF4G2 MACF1	4.75e-04	20	56	2	21689717
Pubmed	Therapeutic targeting of the USP2-E2F4 axis inhibits autophagic machinery essential for zinc homeostasis in cancer progression.	SF3B1 MORF4L1 CD2BP2 NUP214 ATP1A1	4.79e-04	403	56	5	35253629
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	POLH NUP214 UTRN TP53BP2 KNL1	5.65e-04	418	56	5	34709266
Pubmed	Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2.	SPTBN4 SPTA1	7.46e-04	25	56	2	8493579
Pubmed	Ubiquitin ligase MARCH5 localizes to peroxisomes to regulate pexophagy.	TMX1 ATP1A1	7.46e-04	25	56	2	34747980
Pubmed	Analysis of a lung defect in autophagy-deficient mouse strains.	PYGB PYGL	8.07e-04	26	56	2	24275123
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	SPTBN4 FRY SF3B1 USP28 MORF4L1 MACF1 TP53BP2	8.69e-04	963	56	7	28671696
Pubmed	Definition of mouse chromosome 1 and 3 gene linkage groups that are conserved on human chromosome 1: evidence that a conserved linkage group spans the centromere of human chromosome 1.	SPTA1 ATP1A1	8.71e-04	27	56	2	2574151
Pubmed	The MEV mouse linkage testing stock: mapping 30 novel proviral insertions and establishment of an improved stock.	SPTA1 PGM2	8.71e-04	27	56	2	8390965
Pubmed	Laser capture microdissection and cDNA array analysis for identification of mouse KIAA/FLJ genes differentially expressed in the embryonic dorsal spinal cord.	MACF1 NUP214	8.71e-04	27	56	2	19026994
Pubmed	Ubiquilin 2 modulates ALS/FTD-linked FUS-RNA complex dynamics and stress granule formation.	TMX1 SF3B1 EIF4G2 ATP1A1	9.37e-04	269	56	4	30442662
Pubmed	Chromosomal localization of human Na+, K+-ATPase alpha- and beta-subunit genes.	SPTA1 ATP1A1	1.08e-03	30	56	2	2842249
Pubmed	The Tumor Suppressor SASH1 Interacts With the Signal Adaptor CRKL to Inhibit Epithelial-Mesenchymal Transition and Metastasis in Colorectal Cancer.	EPS8L2 UTRN	1.08e-03	30	56	2	30480076
Pubmed	BTB-ZF factors recruit the E3 ligase cullin 3 to regulate lymphoid effector programs.	SF3B1 NUP214	1.15e-03	31	56	2	23086144
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	BPTF SF3B1 USP28 CD2BP2 EIF4G2 PYGB PYGL	1.17e-03	1014	56	7	32416067
Pubmed	OTUD6A Is an Aurora Kinase A-Specific Deubiquitinase.	USP28 OTUD7A	1.22e-03	32	56	2	33669244
Pubmed	alphaII-Spectrin interacts with five groups of functionally important proteins in the nucleus.	SPTBN4 SPTA1	1.38e-03	34	56	2	16889989
Pubmed	HAUSP regulates c-MYC expression via de-ubiquitination of TRRAP.	MACF1 UTRN	1.38e-03	34	56	2	25925205
Pubmed	Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives.	BPTF PYGB PYGL MAP3K12	1.51e-03	306	56	4	18973680
Pubmed	Identification of phagocytosis regulators using magnetic genome-wide CRISPR screens.	MACF1 PYGL APOBR	1.61e-03	143	56	3	30397336
Cytoband	19q13.13	SPTBN4 WDR87	1.52e-04	15	56	2	19q13.13
Cytoband	1p36.13	IFFO2 CROCCP2	2.16e-03	56	56	2	1p36.13
Cytoband	12q13	BIN2 MAP3K12	3.44e-03	71	56	2	12q13
GeneFamily	Glycogen phosphorylases	PYGB PYGL	1.09e-05	3	35	2	437
GeneFamily	EF-hand domain containing\|Spectrins	SPTBN4 SPTA1	7.60e-05	7	35	2	1113
GeneFamily	Dyneins, axonemal	DNAH12 DNAH2	4.86e-04	17	35	2	536
GeneFamily	EF-hand domain containing	TCHH SPTA1 MACF1 TBC1D9	8.17e-04	219	35	4	863
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	CD2BP2 TP53BP2 KNL1	5.10e-03	181	35	3	694
ToppCell	Control-NK\|Control / Disease condition and Cell class	USP28 MACF1 BIN2 APOBR UTRN	5.12e-06	199	56	5	f3316fb97c6065286ffd22a0ad9fe7aa5b3b5650
ToppCell	10x_3'_v3-thymus_(10x_3'_v3)-lymphocytic-T_lymphocytic-mature_NK_T_cell\|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	USP28 MACF1 BIN2 APOBR	6.63e-05	173	56	4	36a471576a9d2325066bb14c2f2cd89c67b92915
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8\|GI_small-bowel / Manually curated celltypes from each tissue	MARCHF6 MACF1 UTRN TP53BP2	9.15e-05	188	56	4	ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCell	PND10\|World / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	BPTF EIF4G2 MACF1 UTRN	9.53e-05	190	56	4	d67e2814047c8df2ae4b7bc8be9539f5df6ecef2
ToppCell	background-NK_cells\|background / Sample and Cell Type and Tumor Cluster (all cells)	USP28 BIN2 APOBR UTRN	1.01e-04	193	56	4	f8d6eff1e04926f85d265ec39fe66897fe29574d
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb-3m\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SF3B1 EIF4G2 ATP1A1 UTRN	1.07e-04	196	56	4	151f1a29a91f8b234e9b6ed062666357a2f69128
ToppCell	facs-Trachea-3m\|Trachea / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TMX1 SF3B1 MORF4L1 ATP1A1	1.10e-04	197	56	4	e77016d64b1cac9825fec7cfe5071f1567401187
ToppCell	10x5'v1-week_12-13-Myeloid_neutrophil-granulo-neutrophil-neutrophil\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	PYGL BIN2 NUP214 APOBR	1.10e-04	197	56	4	8dd10962b6ba587512b2e68c762ade68c751cbc8
ToppCell	facs-Trachea-nan-3m\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMX1 SF3B1 MORF4L1 ATP1A1	1.10e-04	197	56	4	0353d925ee4b7aefc2c51b5fab873f465cdf9ebc
ToppCell	LPS_anti-TNF-Epithelial_alveolar-AT_1-Differentiating_AT2\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	EPS8L2 EPS8L1 ATP1A1 UTRN	1.10e-04	197	56	4	3d13a4f2e86422900ee2194e8a1fd1cf9750d5d3
ToppCell	healthy_donor-Lymphocytic-ILC-NK_cell\|healthy_donor / Disease condition, Lineage, Cell class and subclass	MACF1 BIN2 APOBR UTRN	1.12e-04	198	56	4	d7053a898e04478c577381085f615edaad3cdc5b
ToppCell	healthy_donor-Lymphocytic-ILC\|healthy_donor / Disease condition, Lineage, Cell class and subclass	MACF1 BIN2 APOBR UTRN	1.12e-04	198	56	4	aa33be29e26f1b8facfc894413099083ae3bbb1b
ToppCell	Control_saline-Epithelial_alveolar-AT_1-Differentiating_AT1\|Control_saline / Treatment groups by lineage, cell group, cell type	EPS8L2 EPS8L1 UTRN TP53BP2	1.12e-04	198	56	4	85f424cd9bb3117c9e322031024aabb87696ce47
ToppCell	PBMC-Control-Lymphocyte-T/NK-NK_cell\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	USP28 MACF1 BIN2 UTRN	1.14e-04	199	56	4	eb05ccae5187e4701bbbe6d714a6d2808fbcf306
ToppCell	PBMC-Control-Lymphocyte-T/NK-NK_cell\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	USP28 MACF1 BIN2 UTRN	1.14e-04	199	56	4	10c8729b779073c3bf808e85958d59147f0be5c5
ToppCell	PBMC-Control-Lymphocyte-T/NK-NK_cell-NK-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	USP28 MACF1 BIN2 UTRN	1.14e-04	199	56	4	867fd292f3879982422e840e087bfdb3b21a8715
ToppCell	Control-Lymphoid_T/NK-NK\|Control / Disease group, lineage and cell class	USP28 MACF1 BIN2 UTRN	1.14e-04	199	56	4	94b2693a8378b9b2c58c6aebb2c6658d75b2e3de
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MACF1 TOP6BL ATP1A1 TBC1D9	1.14e-04	199	56	4	3cd6383c50ce342fe5c175e2e50784d634a90e80
ToppCell	PBMC-Control-Lymphocyte-T/NK-NK_cell-NK\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	USP28 MACF1 BIN2 UTRN	1.14e-04	199	56	4	4820f5bcd7bc34c2ebf6a3422cc8eb383a3b5a4e
ToppCell	COVID-19\|World / Disease, condition lineage and cell class	BPTF SF3B1 MACF1 UTRN	1.16e-04	200	56	4	7dec470c379cd89f05a0f37c8628b21f136e52f0
ToppCell	LPS_only-Epithelial_alveolar-AT_1\|LPS_only / Treatment groups by lineage, cell group, cell type	EPS8L2 EPS8L1 ATP1A1 UTRN	1.16e-04	200	56	4	9a6ae40f3e17cd44ee5fd73260713b920aa2ea15
ToppCell	LPS_only-Hematopoietic_Myeloid-Granulocytic_cells-Mast-cells\|LPS_only / Treatment groups by lineage, cell group, cell type	SPTBN4 GDPD5 MMEL1 PGM2	1.16e-04	200	56	4	afbbfe0b8e66df36c244935182cb26feeb31a085
ToppCell	Control-Control-Lymphocyte-T/NK-NK\|Control / Disease, condition lineage and cell class	USP28 MACF1 BIN2 UTRN	1.16e-04	200	56	4	c64c27dbf4df42ca2ad2bd94b50fab87b4050ef3
ToppCell	mild\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	BPTF SF3B1 MACF1 UTRN	1.16e-04	200	56	4	12f1685ce8f218433068e090c9d839cd5a1910bf
ToppCell	VE\|World / Condition, Cell_class and T cell subcluster	BPTF SF3B1 MACF1 UTRN	1.16e-04	200	56	4	8ae7cb81de3ffac5acdf3466d4b516d80cac95d3
Drug	estradiol, USP; Down 200; 0.01uM; HL60; HT_HG-U133A	EVI5 GDPD5 TMPRSS15 SPAM1 EPS8L1 MAP3K12 ATPAF2	4.35e-07	195	55	7	6200_DN
Drug	5-Iodoribose 1-phosphate	PYGB PYGL PGM2	1.11e-06	9	55	3	CID003035973
Drug	5'-iodo-5'-deoxyadenosine	PYGB PYGL PGM2	1.11e-06	9	55	3	CID000107502
Drug	5-(2-chloroethyl)uracil	PYGB PYGL	5.73e-06	2	55	2	CID010442204
Drug	6878P	PYGB PYGL	5.73e-06	2	55	2	CID002725013
Drug	AC1LBRFU	PYGB PYGL	5.73e-06	2	55	2	CID000562981
Drug	pyridoxine phosphate	CD2BP2 PYGB PYGL PGM2	5.96e-06	49	55	4	CID000001055
Drug	3,5-dimethylphenyl isocyanate	PYGB PYGL	1.72e-05	3	55	2	CID000521488
Drug	5-ethyl-4-hydroxy-2-methyl-3(2H)-furanone	PYGB PYGL	1.72e-05	3	55	2	CID000093111
Drug	adenosine-5'-chloromethylphosphonate	PYGB PYGL	1.72e-05	3	55	2	CID000191554
Drug	hydan	PYGB PYGL	1.72e-05	3	55	2	CID000008360
Drug	EHMF	PYGB PYGL	1.72e-05	3	55	2	CID000033931
Drug	AC1L29EX	PYGB PYGL	1.72e-05	3	55	2	CID000043221
Drug	5'-deoxy-5'-fluoro-5'-(methylthio)adenosine	PYGB PYGL	1.72e-05	3	55	2	CID000147839
Drug	pyridoxal 5'-methylenephosphonate	PYGB PYGL	1.72e-05	3	55	2	CID003082249
Drug	Plp 5'-mpa	PYGB PYGL	1.72e-05	3	55	2	CID003082151
Drug	glucose-1,2-cyclic phosphate	PYGB PYGL	1.72e-05	3	55	2	CID000191723
Drug	3'-FFdUrd	PYGB PYGL	1.72e-05	3	55	2	CID000072260
Drug	2',3',4',5,5'-pentachloro-2-biphenylol	PYGB PYGL	1.72e-05	3	55	2	CID000119518
Drug	AC1L8XK3	PYGB PYGL	1.72e-05	3	55	2	CID000409735
Drug	N-acetyl-N'-beta-D-glucopyranosyl urea	PYGB PYGL	1.72e-05	3	55	2	CID000446801
Drug	NSC758405	PYGB PYGL	1.72e-05	3	55	2	CID000003201
Drug	3,5-dinitrophenyl phosphate	PYGB PYGL	1.72e-05	3	55	2	CID000151920
Drug	riboflavin tetraacetate	PYGB PYGL	1.72e-05	3	55	2	CID000094186
Drug	pyridoxal phosphoglucose	PYGB PYGL	1.72e-05	3	55	2	CID000196007
Drug	Aspaminol	PYGB PYGL	1.72e-05	3	55	2	CID003084278
Drug	2,5-dimethyl-3-furanone	PYGB PYGL	1.72e-05	3	55	2	CID000085730
Drug	3,5-dinitrophenol	PYGB PYGL	1.72e-05	3	55	2	CID000011459
Drug	BrVarafUTP	POLH PYGB PYGL	2.60e-05	24	55	3	CID005273539
Drug	hexylamine	PYGB PYGL NUP214	2.95e-05	25	55	3	CID000008102
Drug	galocitabine	PYGB PYGL	3.43e-05	4	55	2	CID000065950
Drug	2,5-anhydro-D-mannitol 1-phosphate	PYGB PYGL	3.43e-05	4	55	2	CID000189134
Drug	AC1LAMW2	PYGB PYGL	3.43e-05	4	55	2	CID000491364
Drug	FdUrd-C8	PYGB PYGL	3.43e-05	4	55	2	CID000094262
Drug	Mem-CC	PYGB PYGL	3.43e-05	4	55	2	CID003081269
Drug	5-deoxyribose-1-phosphate	PYGB PYGL	3.43e-05	4	55	2	CID000135786
Drug	2H-5a	PYGB PYGL	3.43e-05	4	55	2	CID000440102
Drug	ingliforib	PYGB PYGL	3.43e-05	4	55	2	CID006451325
Drug	uric acid riboside	PYGB PYGL	3.43e-05	4	55	2	CID000164933
Drug	pseudo-dl-glucose	PYGB PYGL	3.43e-05	4	55	2	CID000125259
Drug	BCIp4A	PYGB PYGL	3.43e-05	4	55	2	CID000192417
Drug	pyridoxal diphosphate	PYGB PYGL	3.43e-05	4	55	2	CID000125696
Drug	3'-chloromethotrexate	PYGB PYGL	3.43e-05	4	55	2	CID000097703
Drug	plakin	SPTBN4 SPTA1 MACF1 UTRN	4.63e-05	82	55	4	CID000018752
Drug	heptulose-2-P	PYGB PYGL	5.70e-05	5	55	2	CID000124823
Drug	m-anisidine	PYGB PYGL	5.70e-05	5	55	2	CID000010824
Drug	6-FPLP	PYGB PYGL	5.70e-05	5	55	2	CID000146246
Drug	gluconohydroximo-1,5-lactone	PYGB PYGL	5.70e-05	5	55	2	CID009576855
Drug	2-hydroxypropylphosphonate	PYGB PYGL	5.70e-05	5	55	2	CID000441028
Drug	DHPBU	PYGB PYGL	5.70e-05	5	55	2	CID000125914
Drug	6-FDPL	PYGB PYGL	5.70e-05	5	55	2	CID000129578
Drug	5'-isobutylthioinosine	PYGB PYGL	5.70e-05	5	55	2	CID003080910
Drug	3'-O-methylpyridoxal 5'-phosphate	PYGB PYGL	5.70e-05	5	55	2	CID003082179
Drug	GlcMan	PYGB PYGL	5.70e-05	5	55	2	CID000152120
Drug	U66985	PYGB PYGL	5.70e-05	5	55	2	CID000127224
Drug	indirubin-5-sulphonate	PYGB PYGL	5.70e-05	5	55	2	CID005288641
Drug	VaraU	PYGB PYGL	5.70e-05	5	55	2	CID000126501
Drug	AC1O3M08	PYGB PYGL	5.70e-05	5	55	2	CID006331955
Drug	AC1LCUXJ	PYGB PYGL	5.70e-05	5	55	2	CID000656425
Drug	6-amino-5-bromouracil	PYGB PYGL	5.70e-05	5	55	2	CID000080578
Drug	etafenone	PYGB PYGL	5.70e-05	5	55	2	CID000003275
Drug	ddEtUrd	PYGB PYGL	5.70e-05	5	55	2	CID000451452
Drug	5-trifluoromethyl-2'-deoxycytidine	PYGB PYGL	5.70e-05	5	55	2	CID000125618
Drug	BrdAdo	PYGB PYGL	5.70e-05	5	55	2	CID000055914
Drug	meprobamate	TMPRSS15 MMEL1 PYGB PYGL	6.11e-05	88	55	4	CID000004064
Drug	norstatine	PYGB PYGL	8.54e-05	6	55	2	CID000173844
Drug	CV-araU	PYGB PYGL	8.54e-05	6	55	2	CID006441877
Drug	2-thiothymidine	PYGB PYGL	8.54e-05	6	55	2	CID003005944
Drug	Carbocyclic Bvdc	PYGB PYGL	8.54e-05	6	55	2	CID006438602
Drug	AC1NDJ6Q	PYGB PYGL	8.54e-05	6	55	2	CID004602095
Drug	DNPP	PYGB PYGL	8.54e-05	6	55	2	CID000067056
Drug	5-chloro-indole-2-carboxylic acid	PYGB PYGL	8.54e-05	6	55	2	CID000082693
Drug	2,2-dimethyl-3-hydroxybutyric acid	PYGB PYGL	8.54e-05	6	55	2	CID000152984
Drug	EdUMP	PYGB PYGL	8.54e-05	6	55	2	CID003085112
Drug	5'-deoxy-5'-chloroformycin	PYGB PYGL	8.54e-05	6	55	2	CID000126430
Drug	NSC-97433	PYGB PYGL	8.54e-05	6	55	2	CID000001803
Drug	5-n-propylthioadenosine	PYGB PYGL	8.54e-05	6	55	2	CID000656428
Drug	AzddCyd	PYGB PYGL	8.54e-05	6	55	2	CID000451374
Drug	BAY R3401	PYGB PYGL	8.54e-05	6	55	2	CID009842599
Drug	5-Ffdru	PYGB PYGL	8.54e-05	6	55	2	CID000065561
Drug	AR-L57	PYGB PYGL	8.54e-05	6	55	2	CID000156890
Drug	Carbocyclic Ivdu	PYGB PYGL	8.54e-05	6	55	2	CID006439191
Drug	6-hydroxyluteolin	PYGB PYGL	8.54e-05	6	55	2	CID005281642
Drug	brilliant yellow	PYGB PYGL	8.54e-05	6	55	2	CID005462609
Drug	nojirimycin	MORF4L1 PYGB PYGL	1.06e-04	38	55	3	CID000065242
Drug	L-BVAU	POLH PYGB PYGL	1.06e-04	38	55	3	CID000667554
Drug	Amitryptiline hydrochloride [549-18-8]; Down 200; 12.8uM; PC3; HT_HG-U133A	WDR74 POLH EPS8L1 TOP6BL TBC1D9	1.08e-04	195	55	5	1823_DN
Drug	Sulfamethoxazole [723-46-6]; Up 200; 15.8uM; MCF7; HT_HG-U133A	TMPRSS15 SPAM1 TCHH SPTA1 UTRN	1.10e-04	196	55	5	2296_UP
Drug	Pentolinium bitartrate [52-62-0]; Up 200; 7.4uM; MCF7; HT_HG-U133A	SPTBN4 SPAM1 TCHH NUP214 ATPAF2	1.13e-04	197	55	5	2305_UP
Drug	Gramine [87-52-5]; Down 200; 23uM; PC3; HT_HG-U133A	SPAM1 POLH NUP214 EPS8L1 TBC1D9	1.13e-04	197	55	5	3999_DN
Drug	Streptomycin sulfate [3810-74-0]; Up 200; 2.8uM; MCF7; HT_HG-U133A	GDPD5 SPTA1 NUP214 EPS8L1 ATPAF2	1.13e-04	197	55	5	3195_UP
Drug	S(+)-Terguride [37686-84-3]; Down 200; 11.8uM; MCF7; HT_HG-U133A	EVI5 TCHH POLH MAP3K12 TBC1D9	1.16e-04	198	55	5	6459_DN
Drug	Dropropizine (R,S) [17692-31-8]; Up 200; 17uM; MCF7; HT_HG-U133A	EVI5 GDPD5 POLH EPS8L1 MAP3K12	1.18e-04	199	55	5	7429_UP
Drug	Ornidazole [16773-42-5]; Up 200; 18.2uM; PC3; HT_HG-U133A	SPAM1 NUP214 EPS8L1 UTRN MAP3K12	1.18e-04	199	55	5	2109_UP
Drug	alpha-(fluoromethyl)dehydroornithine	PYGB PYGL	1.19e-04	7	55	2	CID006439607
Drug	6-fluoropyridoxal	PYGB PYGL	1.19e-04	7	55	2	CID003080803
Drug	2',3'-dideoxy-3'-fluorocytidine	PYGB PYGL	1.19e-04	7	55	2	CID000356019
Drug	heptenitol	PYGB PYGL	1.19e-04	7	55	2	CID000188267
Drug	3-methylcytidine	PYGB PYGL	1.19e-04	7	55	2	CID000159649
Drug	AC1L3372	PYGB PYGL	1.19e-04	7	55	2	CID000108025
Disease	loneliness measurement	BPTF MACF1 UTRN	1.46e-03	124	53	3	EFO_0007865
Disease	vascular endothelial growth factor measurement	POLH DNAH2	4.58e-03	56	53	2	EFO_0004762
Disease	peripheral arterial disease, traffic air pollution measurement	PYGB MACF1 UTRN	5.15e-03	194	53	3	EFO_0004265, EFO_0007908
Disease	alcohol use disorder (implicated_via_orthology)	EPS8L2 EPS8L1 ATP1A1	5.22e-03	195	53	3	DOID:1574 (implicated_via_orthology)
Disease	calcium measurement	SMIM23 DNAH2 PYGB MACF1 ATP1A1	5.32e-03	628	53	5	EFO_0004838
Disease	eye morphology measurement	SMIM23 FRY EIF4G2	7.10e-03	218	53	3	EFO_0007858

Protein segments in the cluster

Peptide	Gene	Start	Entry
LDGNIVSWEEDVWLV	ADGRG4	201	Q8IZF6
TWVAEEELELWEIRA	BPTF	2011	Q12830
AIVWNNDLLWEDYEE	BIN2	101	Q9UBW5
DEDEIEWWWARLNDK	TP53BP2	1091	Q13625
WLVDDWDLITRQKQL	MORF4L1	206	Q9UBU8
EALIGRWSWDDIQVE	MAGED4	641	Q96JG8
RWSWDDIQVELLTWD	MAGED4	646	Q96JG8
VELQRNEWDPIIEWA	ATPAF2	151	Q8N5M1
LRVDWDDRWINDVED	ATP1A1	886	P05023
WVQDLNDDNEWERIQ	TMPRSS15	356	P98073
EEDSWILWGRIVNEW	EVI5	131	O60447
WEDRLIRIQETIDEW	DNAH12	891	Q6ZR08
EDARLDQETAQWLRW	PGM2	11	Q96G03
AELLEELLAWIQWAE	MACF1	3011	O94854
NALEWDRAAEELTWE	MARCHF6	261	O60337
RQSDQINWESWLLED	NUP214	331	P35658
LLDQLSLSEWDVVEW	KNL1	2126	Q8NG31
WEQEEKEWQQQRLPE	GOLGA6L2	481	Q8N9W4
WRQEEKIREQEEIWR	GOLGA6L22	401	H0YM25
AVAQLWEDEWEVLLI	GDPD5	141	Q8WTR4
WEDEWEVLLISLQGT	GDPD5	146	Q8WTR4
WADQIVLQWERVTAE	LRRC42	306	Q9Y546
QQNKEEEWEREWTEL	OTUD7A	256	Q8TE49
WNETVGLEWELERQL	MMEL1	206	Q495T6
QVNQWLTWLETAEEE	EIF4G2	886	P78344
DEVLEVLEDGRQWWK	EPS8L2	516	Q9H6S3
RDSWLDNIDWVKIRE	CD2BP2	116	O95400
DLWEVPFEEILDLQW	MAP3K12	116	Q12852
LTWEENEDTLLLWED	IFFO2	381	Q5TF58
VEIKRNDDLSWLWNE	SPAM1	241	P38567
VDLQWLVEWNAVLVN	FRY	816	Q5TBA9
TLANILAWLEEWNDV	FAM186A	126	A6NE01
QRDVLEVLDDSRKWW	EPS8L1	501	Q8TE68
APAEQEWLEELWLEQ	CROCCP2	86	Q86T23
EWLEELWLEQEVARQ	CROCCP2	91	Q86T23
ELDALQQIWEIARDW	DNAH2	1226	Q9P225
ETRDAWWAEIRQEIK	C2CD5	386	Q86YS7
ERQEEDIRWLWSEVE	TARS3	16	A2RTX5
WTEERWNRLQEINIL	UTRN	516	P46939
EEEIANMLQWEELEW	DROSHA	716	Q9NRR4
EDVLWLQEVSNLSEW	TOP6BL	556	Q8N6T0
VQQLEQLAWDLELWL	SMIM23	111	A6NLE4
QVQWWLLQLAQELEE	POLH	336	Q9Y253
WTLLEEEAVGWQERE	APOBR	881	Q0VD83
LVSRLEQWEEPWVED	ZNF707	56	Q96C28
DWLDLRVPIWDQDIQ	WDR74	176	Q6RFH5
EQLQAWRWEREIDER	SF3B1	381	O75533
TWDAWNERLLEIEKE	STYXL2	476	Q5VZP5
EITEHWEWLEQNLLQ	TBC1D9	86	Q6ZT07
IVNGWQVEEADDWLR	PYGB	171	P11216
LWALLQELEEAESWA	SPTBN4	646	Q9H254
AEDLQRWLEDVEWQV	SPTA1	696	P02549
IQEDNWRFEQEVEEW	USP28	681	Q96RU2
EDVAVEFTWEEWQLL	ZNF613	11	Q6PF04
TEQEWENLEDWQKEL	ZNF212	151	Q9UDV6
IRDGWQVEEADDWLR	PYGL	171	P06737
DENWRELLEGDWMIE	TMX1	36	Q9H3N1
EELWRQRQEWQEREE	TCHH	171	Q07283
EEQRRDFTWQWQAEE	TCHH	761	Q07283
QELEELEWDMEELSW	WDR87	1716	Q6ZQQ6