Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	structural constituent of skin epidermis	KRT2 KRT3 KRT76	2.62e-05	43	27	3	GO:0030280
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	NPAS3 ZNF384 POU4F1 HOXD11 TAL1 PURB BHLHE22 ZBTB4	4.03e-04	1412	27	8	GO:0000981
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	NPAS3 ZNF384 POU4F1 HOXD11 TAL1 PURB BHLHE22 ZBTB4	5.03e-04	1459	27	8	GO:0000977
GeneOntologyMolecularFunction	single-stranded DNA binding	POU4F1 HNRNPA2B1 PURB	7.68e-04	134	27	3	GO:0003697
GeneOntologyMolecularFunction	SH3 domain binding	CBLC ZNF384 WIPF1	9.27e-04	143	27	3	GO:0017124
GeneOntologyBiologicalProcess	central nervous system neuron differentiation	POU4F1 GDF7 NRXN1 TAL1 BHLHE22	8.23e-06	217	27	5	GO:0021953
GeneOntologyBiologicalProcess	gamma-aminobutyric acid receptor clustering	NRXN1 SHISA7	1.65e-05	5	27	2	GO:0097112
GeneOntologyBiologicalProcess	startle response	NPAS3 GRIN2D NRXN1	2.06e-05	41	27	3	GO:0001964
GeneOntologyBiologicalProcess	intermediate filament organization	KRT2 KRT3 KRT76	1.27e-04	75	27	3	GO:0045109
GeneOntologyBiologicalProcess	spinal cord association neuron differentiation	GDF7 TAL1	1.49e-04	14	27	2	GO:0021527
GeneOntologyBiologicalProcess	keratinization	KRT2 KRT3 KRT76	1.97e-04	87	27	3	GO:0031424
GeneOntologyBiologicalProcess	neuromuscular process	NPAS3 POU4F1 GRIN2D NRXN1	1.99e-04	225	27	4	GO:0050905
GeneOntologyBiologicalProcess	intermediate filament cytoskeleton organization	KRT2 KRT3 KRT76	2.89e-04	99	27	3	GO:0045104
GeneOntologyBiologicalProcess	intermediate filament-based process	KRT2 KRT3 KRT76	2.97e-04	100	27	3	GO:0045103
GeneOntologyBiologicalProcess	neurotransmitter-gated ion channel clustering	NRXN1 SHISA7	3.75e-04	22	27	2	GO:0072578
GeneOntologyBiologicalProcess	dorsal spinal cord development	GDF7 TAL1	3.75e-04	22	27	2	GO:0021516
GeneOntologyBiologicalProcess	regulation of AMPA receptor activity	NRXN1 SHISA7	4.86e-04	25	27	2	GO:2000311
GeneOntologyBiologicalProcess	regulation of signaling receptor activity	CBLC NRXN1 SHISA7	6.55e-04	131	27	3	GO:0010469
GeneOntologyBiologicalProcess	glutamatergic neuron differentiation	NRXN1 BHLHE22	6.56e-04	29	27	2	GO:1905962
GeneOntologyCellularComponent	dendritic spine membrane	KCNC3 SHISA7	2.43e-04	18	27	2	GO:0032591
GeneOntologyCellularComponent	keratin filament	KRT2 KRT3 KRT76	2.61e-04	97	27	3	GO:0045095
GeneOntologyCellularComponent	glutamatergic synapse	DOC2A GRIN2D NRXN1 KCNC3 HNRNPA2B1 SHISA7	5.12e-04	817	27	6	GO:0098978
Domain	Keratin_2_head	KRT2 KRT3 KRT76	5.34e-06	24	27	3	IPR032444
Domain	Keratin_2_head	KRT2 KRT3 KRT76	5.34e-06	24	27	3	PF16208
Domain	Keratin_II	KRT2 KRT3 KRT76	6.85e-06	26	27	3	IPR003054
Domain	Intermediate_filament_CS	KRT2 KRT3 KRT76	1.01e-04	63	27	3	IPR018039
Domain	GrpE_coiled_coil	KRT3 KRT76	1.32e-04	12	27	2	IPR013805
Domain	Filament	KRT2 KRT3 KRT76	1.44e-04	71	27	3	SM01391
Domain	IF	KRT2 KRT3 KRT76	1.50e-04	72	27	3	PS00226
Domain	Filament	KRT2 KRT3 KRT76	1.57e-04	73	27	3	PF00038
Domain	IF	KRT2 KRT3 KRT76	1.77e-04	76	27	3	IPR001664
Domain	-	NPAS3 TAL1 BHLHE22	5.11e-04	109	27	3	4.10.280.10
Domain	HLH	NPAS3 TAL1 BHLHE22	5.39e-04	111	27	3	PF00010
Domain	HLH	NPAS3 TAL1 BHLHE22	6.12e-04	116	27	3	SM00353
Domain	BHLH	NPAS3 TAL1 BHLHE22	6.28e-04	117	27	3	PS50888
Domain	bHLH_dom	NPAS3 TAL1 BHLHE22	6.44e-04	118	27	3	IPR011598
Domain	Keratin_I	KRT3 KRT76	1.83e-03	44	27	2	IPR002957
Pubmed	A census of human transcription factors: function, expression and evolution.	NPAS3 ZNF384 POU4F1 HOXD11 TAL1 BHLHE22 ZBTB4	4.54e-06	908	27	7	19274049
Pubmed	A bead-based approach for large-scale identification of in vitro kinase substrates.	OSBP HNRNPA2B1 PURB USP24	7.50e-06	163	27	4	22113938
Pubmed	Dicer is required for the maintenance of notch signaling and gliogenic competence during mouse retinal development.	POU4F1 BHLHE22	8.69e-06	6	27	2	21542136
Pubmed	RNF208, an estrogen-inducible E3 ligase, targets soluble Vimentin to suppress metastasis in triple-negative breast cancers.	KRT2 KRT3 KRT76	1.19e-05	57	27	3	31862882
Pubmed	New consensus nomenclature for mammalian keratins.	KRT2 KRT3 KRT76	1.61e-05	63	27	3	16831889
Pubmed	Characterization of new members of the human type II keratin gene family and a general evaluation of the keratin gene domain on chromosome 12q13.13.	KRT3 KRT76	2.08e-05	9	27	2	15737194
Pubmed	Genetic chimeras reveal the autonomy requirements for Vsx2 in embryonic retinal progenitor cells.	POU4F1 BHLHE22	2.08e-05	9	27	2	25927996
Pubmed	Sonic hedgehog regulates proliferation and inhibits differentiation of CNS precursor cells.	POU4F1 GDF7	4.50e-05	13	27	2	10516314
Pubmed	Hindbrain rhombic lip is comprised of discrete progenitor cell populations allocated by Pax6.	POU4F1 GDF7	5.25e-05	14	27	2	16364898
Pubmed	An oocyte-specific ELAVL2 isoform is a translational repressor ablated from meiotically competent antral oocytes.	HNRNPA2B1 KHSRP	5.25e-05	14	27	2	24553115
Pubmed	Phylogenetic and expression analysis of the basic helix-loop-helix transcription factor gene family: genomic approach to cellular differentiation.	NPAS3 TAL1 BHLHE22	6.04e-05	98	27	3	18557763
Pubmed	Proteomic analysis reveals that MAEL, a component of nuage, interacts with stress granule proteins in cancer cells.	HNRNPA2B1 KHSRP	6.06e-05	15	27	2	24189637
Pubmed	Sensory Neuron Diversity in the Inner Ear Is Shaped by Activity.	POU4F1 BHLHE22	6.06e-05	15	27	2	30078709
Pubmed	Control of neuronal morphology by the atypical cadherin Fat3.	POU4F1 BHLHE22	6.92e-05	16	27	2	21903076
Pubmed	Prdm13 is required for Ebf3+ amacrine cell formation in the retina.	POU4F1 BHLHE22	6.92e-05	16	27	2	29258872
Pubmed	Proprioceptor pathway development is dependent on Math1.	POU4F1 GDF7	6.92e-05	16	27	2	11395003
Pubmed	BARHL2 differentially regulates the development of retinal amacrine and ganglion neurons.	POU4F1 BHLHE22	6.92e-05	16	27	2	19339595
Pubmed	The Onecut Transcription Factors Regulate Differentiation and Distribution of Dorsal Interneurons during Spinal Cord Development.	POU4F1 BHLHE22	6.92e-05	16	27	2	28603487
Pubmed	Hairy/Enhancer-of-Split MEGANE and Proneural MASH1 Factors Cooperate Synergistically in Midbrain GABAergic Neurogenesis.	POU4F1 TAL1	6.92e-05	16	27	2	25993409
Pubmed	KCTD9 inhibits the Wnt/β-catenin pathway by decreasing the level of β-catenin in colorectal cancer.	KRT2 HNRNPA2B1 KHSRP	7.21e-05	104	27	3	36055981
Pubmed	Selective expression of Bhlhb5 in subsets of early-born interneurons and late-born association neurons in the spinal cord.	POU4F1 BHLHE22	7.84e-05	17	27	2	17219401
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	DOC2A KRT2 KRT3 KRT76 NRXN1 HNRNPA2B1 KHSRP	8.88e-05	1442	27	7	35575683
Pubmed	Elucidation of the BMI1 interactome identifies novel regulatory roles in glioblastoma.	OSBP KRT76 PURB KHSRP	1.16e-04	329	27	4	34316702
Pubmed	Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.	GRIN2D WIPF1 TAL1 KHSRP	1.16e-04	329	27	4	17474147
Pubmed	Subtype specification of GABAergic amacrine cells by the orphan nuclear receptor Nr4a2/Nurr1.	POU4F1 BHLHE22	1.21e-04	21	27	2	19692620
Pubmed	Sequential Role of SOXB2 Factors in GABAergic Neuron Specification of the Dorsal Midbrain.	POU4F1 BHLHE22	1.21e-04	21	27	2	29867344
Pubmed	EEF1D Promotes Glioma Proliferation, Migration, and Invasion through EMT and PI3K/Akt Pathway.	KRT2 KHSRP	1.21e-04	21	27	2	33029523
Pubmed	The role of Tal2 and Tal1 in the differentiation of midbrain GABAergic neuron precursors.	POU4F1 TAL1	1.21e-04	21	27	2	24167708
Pubmed	Cbln1 regulates axon growth and guidance in multiple neural regions.	POU4F1 NRXN1	1.33e-04	22	27	2	36395107
Pubmed	Inhibition of SAPK2a/p38 prevents hnRNP A0 phosphorylation by MAPKAP-K2 and its interaction with cytokine mRNAs.	HNRNPA2B1 KHSRP	1.33e-04	22	27	2	12456657
Pubmed	DCC is specifically required for the survival of retinal ganglion and displaced amacrine cells in the developing mouse retina.	POU4F1 BHLHE22	1.45e-04	23	27	2	20875817
Pubmed	Sox2 Acts in Thalamic Neurons to Control the Development of Retina-Thalamus-Cortex Connectivity.	POU4F1 BHLHE22	1.45e-04	23	27	2	31082736
Pubmed	Gata2, Nkx2-2 and Skor2 form a transcription factor network regulating development of a midbrain GABAergic neuron subtype with characteristics of REM-sleep regulatory neurons.	POU4F1 TAL1	1.45e-04	23	27	2	35815619
Pubmed	Tfap2a and 2b act downstream of Ptf1a to promote amacrine cell differentiation during retinogenesis.	POU4F1 BHLHE22	1.45e-04	23	27	2	25966682
Pubmed	cDNAs with long CAG trinucleotide repeats from human brain.	ZNF384 BHLHE22	1.45e-04	23	27	2	9225980
Pubmed	E3 Ligase Trim21 Ubiquitylates and Stabilizes Keratin 17 to Induce STAT3 Activation in Psoriasis.	KRT2 HNRNPA2B1 KHSRP	1.56e-04	135	27	3	29859926
Pubmed	Prothymosin-α enhances phosphatase and tensin homolog expression and binds with tripartite motif-containing protein 21 to regulate Kelch-like ECH-associated protein 1/nuclear factor erythroid 2-related factor 2 signaling in human bladder cancer.	KRT2 HNRNPA2B1	1.59e-04	24	27	2	30719818
Pubmed	Interaction of Tumor Necrosis Factor Receptor-associated Factor 6 (TRAF6) and Vav3 in the Receptor Activator of Nuclear Factor κB (RANK) Signaling Complex Enhances Osteoclastogenesis.	KRT2 KRT3	1.59e-04	24	27	2	27507811
Pubmed	Requirement for Bhlhb5 in the specification of amacrine and cone bipolar subtypes in mouse retina.	POU4F1 BHLHE22	1.59e-04	24	27	2	17092954
Pubmed	Immunoprecipitation and mass spectrometry defines an extensive RBM45 protein-protein interaction network.	KRT2 HNRNPA2B1 KHSRP	1.60e-04	136	27	3	26979993
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	DOC2A CBLC ZNF384 ARHGEF40 GRIN2D ZBTB4	1.69e-04	1105	27	6	35748872
Pubmed	Overlapping expression patterns and redundant roles for AP-2 transcription factors in the developing mammalian retina.	POU4F1 BHLHE22	1.72e-04	25	27	2	22411557
Pubmed	The gluconeogenic enzyme PCK1 phosphorylates INSIG1/2 for lipogenesis.	KRT2 KRT76 HNRNPA2B1	1.78e-04	141	27	3	32322062
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	OSBP NRXN1 SHISA7 PURB KHSRP USP24	2.00e-04	1139	27	6	36417873
Pubmed	The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation.	KRT2 KRT3 KRT76 HNRNPA2B1 PURB KHSRP	2.13e-04	1153	27	6	29845934
Pubmed	Dbx1 is a dorsal midbrain-specific determinant of GABAergic neuron fate and regulates differentiation of the dorsal midbrain into the inferior and superior colliculi.	POU4F1 TAL1	2.17e-04	28	27	2	38344749
Pubmed	An isoform of retinoid-related orphan receptor β directs differentiation of retinal amacrine and horizontal interneurons.	POU4F1 BHLHE22	2.33e-04	29	27	2	23652001
Pubmed	Roles of histone H3K27 trimethylase Ezh2 in retinal proliferation and differentiation.	POU4F1 BHLHE22	2.33e-04	29	27	2	25556712
Pubmed	Correct patterning of the primitive streak requires the anterior visceral endoderm.	FZD8 GDF7	2.49e-04	30	27	2	21445260
Pubmed	Necessity and Sufficiency of Ldb1 in the Generation, Differentiation and Maintenance of Non-photoreceptor Cell Types During Retinal Development.	POU4F1 BHLHE22	2.49e-04	30	27	2	30127719
Pubmed	Polycomb repression complex 2 is required for the maintenance of retinal progenitor cells and balanced retinal differentiation.	POU4F1 BHLHE22	2.49e-04	30	27	2	29137925
Pubmed	Maf1 controls retinal neuron number by both RNA Pol III- and Pol II-dependent mechanisms.	POU4F1 BHLHE22	2.66e-04	31	27	2	38089586
Pubmed	Role of Elavl-like RNA-binding protein in retinal development and signal transduction.	POU4F1 NRXN1	2.66e-04	31	27	2	39307290
Pubmed	Regulation of retinal progenitor expansion by Frizzled receptors: implications for microphthalmia and retinal coloboma.	FZD8 POU4F1	2.66e-04	31	27	2	22228100
Pubmed	Recurrent rearrangements in synaptic and neurodevelopmental genes and shared biologic pathways in schizophrenia, autism, and mental retardation.	DOC2A NRXN1	2.66e-04	31	27	2	19736351
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	CBLC OSBP HNRNPA2B1 PURB USP24	2.90e-04	774	27	5	15302935
Pubmed	Selective neuronal lineages derived from Dll4-expressing progenitors/precursors in the retina and spinal cord.	POU4F1 BHLHE22	3.02e-04	33	27	2	25179941
Pubmed	Human variation in alcohol response is influenced by variation in neuronal signaling genes.	NRXN1 HNRNPA2B1 PURB	3.13e-04	171	27	3	20201926
Pubmed	The transcriptional control of trunk neural crest induction, survival, and delamination.	POU4F1 GDF7	3.21e-04	34	27	2	15691760
Pubmed	Patterns of Wnt/Fzd/LRP gene expression during embryonic hematopoiesis.	FZD8 TAL1	3.80e-04	37	27	2	18800919
Pubmed	Requirement of the Mowat-Wilson Syndrome Gene Zeb2 in the Differentiation and Maintenance of Non-photoreceptor Cell Types During Retinal Development.	POU4F1 BHLHE22	4.23e-04	39	27	2	29922981
Pubmed	Gbx2 is essential for maintaining thalamic neuron identity and repressing habenular characters in the developing thalamus.	TAL1 BHLHE22	4.45e-04	40	27	2	26297811
Pubmed	Transcriptional regulation of Oct4 by a long non-coding RNA antisense to Oct4-pseudogene 5.	KRT2 PURB	4.45e-04	40	27	2	21151833
Pubmed	Diverse spinal commissural neuron populations revealed by fate mapping and molecular profiling using a novel Robo3Cre mouse.	POU4F1 BHLHE22	4.45e-04	40	27	2	31152445
Pubmed	RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.	KRT2 ARHGEF40 KHSRP	5.09e-04	202	27	3	24639526
Pubmed	Tcf7l2 plays crucial roles in forebrain development through regulation of thalamic and habenular neuron identity and connectivity.	POU4F1 TAL1	6.14e-04	47	27	2	28219675
Pubmed	Global analysis of TDP-43 interacting proteins reveals strong association with RNA splicing and translation machinery.	HNRNPA2B1 PURB KHSRP	6.79e-04	223	27	3	20020773
Pubmed	FAF1 phosphorylation by AKT accumulates TGF-β type II receptor and drives breast cancer metastasis.	KRT2 HNRNPA2B1 KHSRP	6.88e-04	224	27	3	28443643
Pubmed	WNT signaling affects gene expression in the ventral diencephalon and pituitary gland growth.	FZD8 POU4F1	6.95e-04	50	27	2	18351662
Pubmed	A screen for downstream effectors of Neurogenin2 in the embryonic neocortex.	HNRNPA2B1 BHLHE22	7.51e-04	52	27	2	15328020
Interaction	PHTF1 interactions	KRT2 KRT3 KRT76	2.41e-06	20	27	3	int:PHTF1
Interaction	KRT12 interactions	KRT2 KRT3 KRT76	4.26e-06	24	27	3	int:KRT12
Interaction	KRT28 interactions	KRT2 KRT3 KRT76	8.50e-06	30	27	3	int:KRT28
Interaction	KRT25 interactions	KRT2 KRT3 KRT76	1.36e-05	35	27	3	int:KRT25
Interaction	KRT32 interactions	KRT2 KRT3 KRT76	2.74e-05	44	27	3	int:KRT32
Interaction	KRT84 interactions	KRT2 KRT3 KRT76	3.79e-05	49	27	3	int:KRT84
Interaction	KRT6A interactions	KRT2 KRT3 KRT76 ZBTB4	5.82e-05	160	27	4	int:KRT6A
Interaction	KRT39 interactions	KRT2 KRT3 KRT76	6.63e-05	59	27	3	int:KRT39
Interaction	KRT20 interactions	KRT2 KRT3 KRT76	8.07e-05	63	27	3	int:KRT20
Interaction	KRT36 interactions	KRT2 KRT3 KRT76	1.30e-04	74	27	3	int:KRT36
Interaction	RNF208 interactions	KRT2 KRT3 KRT76	1.36e-04	75	27	3	int:RNF208
Interaction	NEDD8 interactions	MSRB2 KRT2 KRT76 HNRNPA2B1 KHSRP	1.56e-04	393	27	5	int:NEDD8
Interaction	KRT33B interactions	KRT2 KRT3 KRT76	2.57e-04	93	27	3	int:KRT33B
Interaction	KRT37 interactions	KRT2 KRT3 KRT76	3.18e-04	100	27	3	int:KRT37
Interaction	KRT17 interactions	KRT2 KRT76 HNRNPA2B1 KHSRP	3.34e-04	252	27	4	int:KRT17
Interaction	MIRLET7A3 interactions	HNRNPA2B1 PURB KHSRP	3.37e-04	102	27	3	int:MIRLET7A3
Interaction	KRT35 interactions	KRT2 KRT3 KRT76	4.32e-04	111	27	3	int:KRT35
Interaction	COPS5 interactions	KRT2 KRT3 OSBP KRT76 HNRNPA2B1 KHSRP USP24	4.85e-04	1102	27	7	int:COPS5
Interaction	KRT13 interactions	KRT2 KRT3 KRT76	4.91e-04	116	27	3	int:KRT13
Cytoband	12q13.13	KRT2 KRT3 KRT76	8.47e-06	67	27	3	12q13.13
Cytoband	2q31.1	WIPF1 HOXD11	1.13e-03	84	27	2	2q31.1
Cytoband	19q13.33	GRIN2D KCNC3	1.79e-03	106	27	2	19q13.33
Cytoband	Ensembl 112 genes in cytogenetic band chr12q13	KRT2 KRT3 KRT76	1.93e-03	423	27	3	chr12q13
Cytoband	Ensembl 112 genes in cytogenetic band chr2q31	WIPF1 HOXD11	4.92e-03	178	27	2	chr2q31
Cytoband	Ensembl 112 genes in cytogenetic band chr19q13	CBLC GRIN2D KCNC3 SHISA7	4.93e-03	1192	27	4	chr19q13
GeneFamily	Keratins, type II	KRT2 KRT3 KRT76	3.88e-06	27	21	3	609
GeneFamily	Basic helix-loop-helix proteins	NPAS3 TAL1 BHLHE22	2.69e-04	110	21	3	420
GeneFamily	Ataxins\|Trinucleotide repeat containing	ZNF384 BHLHE22	3.79e-04	25	21	2	775
ToppCell	TCGA-Mesothelium-Primary_Tumor-Mesothelioma-Biphasic-3\|TCGA-Mesothelium / Sample_Type by Project: Shred V9	ADRA1D HOXD11 SHISA7	6.11e-05	127	27	3	df2854bcb2708ddc13b3ca48c03887380e827790
ToppCell	10x_3'_v3-lymph_node_(10x_3'_v3)-hematologic\|lymph_node_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	NRXN1 TAL1 SHISA7	9.25e-05	146	27	3	03a6a442f1f6d173a41aeebbfe41ee08853d9585
ToppCell	Cerebellum-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Pvalb\|Cerebellum / BrainAtlas - Mouse McCarroll V32	GRIN2D PURB BHLHE22	9.82e-05	149	27	3	6e9ca280a599d96f8956ef26f2a46b9484de5488
ToppCell	PND01-03-samps-Mesenchymal-Pericyte\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	ADRA1D NRXN1 SHISA7	1.04e-04	152	27	3	fc9472bc19f997103da535b035105f01429cb08e
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L5_IT-L5_IT_VISp_Batf3\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	DOC2A ADRA1D BHLHE22	1.15e-04	157	27	3	921805932f7974d37aed547861d555b07f30aba6
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L4-L4_IT_VISp_Rspo1\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	ADRA1D NRXN1 BHLHE22	1.28e-04	163	27	3	431221a41d396b09170476179590eaf8a55266d8
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ADRA1D GRIN2D HOXD11	1.28e-04	163	27	3	8e32b6431e1862572663aa6ddc4ea299c6acc8a6
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ADRA1D GRIN2D HOXD11	1.28e-04	163	27	3	bbc078761c5043af13d9a6fcf3145a3e300bae5e
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L4\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	ADRA1D NRXN1 BHLHE22	1.28e-04	163	27	3	1e8ab00ecc2d2ba35aa6745c0ed38663e26312e8
ToppCell	droplet-Pancreas-Endocrine-18m-Epithelial-nan\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DOC2A POU4F1 KCNC3	1.35e-04	166	27	3	66026988509e39e41274fa0de738383219e8ff30
ToppCell	PND03-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP2-CAP2_prolif\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FZD8 NRXN1 TAL1	1.40e-04	168	27	3	c7021748003e5949f7caf7b3291c5bad294948c1
ToppCell	droplet-Thymus-nan-21m-Lymphocytic-DN3_thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GRIN2D NRXN1 TAL1	1.61e-04	176	27	3	d43d9e86c4d4fa1e88fbf2b899ac7143717aac90
ToppCell	wk_15-18-Endothelial-Blood_vessel_endothelial-OMD+_endo\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	FZD8 POU4F1 GDF7	1.69e-04	179	27	3	8c9ed247e1c4d655b81ce2f24a9936a7cade718a
ToppCell	facs-Heart-LV-3m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADRA1D NRXN1 BHLHE22	1.74e-04	181	27	3	1db1eb7d330a7e5090994007ae287e11f0a74450
ToppCell	facs-Heart-LV-3m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADRA1D NRXN1 BHLHE22	1.74e-04	181	27	3	06174ce9240c9261c0f51a1b0d875335d60722e5
ToppCell	droplet-Lung-LUNG-1m-Mesenchymal-pericyte_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADRA1D NRXN1 BHLHE22	1.77e-04	182	27	3	9edaccf1154cec92ca9a28e9b1f9075cfd422bfd
ToppCell	droplet-Lung-LUNG-1m-Epithelial-type_II_pneumocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CBLC KCNC3 SHISA7	1.77e-04	182	27	3	c1e0be27064e14043b78ae501b02d4e9542267a3
ToppCell	droplet-Lung-LUNG-1m-Mesenchymal-Pericyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADRA1D NRXN1 BHLHE22	1.77e-04	182	27	3	aba4c06d5d7618ac21b2695bca8e7a1346a91090
ToppCell	droplet-Lung-LUNG-1m-Epithelial-Alveolar_Epithelial_Type_2\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CBLC KCNC3 SHISA7	1.77e-04	182	27	3	3c9b4869d357884ae4bcd22a9872faf83a5cfc6d
ToppCell	droplet-Lung-1m-Mesenchymal-myofibroblast-pericyte_cell\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ADRA1D NRXN1 BHLHE22	1.83e-04	184	27	3	39bb0eb55bdc2cea46e41c7f21d8c5883f14e6bd
ToppCell	droplet-Lung-1m-Mesenchymal-myofibroblast-pericyte_cell-pericyte\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ADRA1D NRXN1 BHLHE22	1.83e-04	184	27	3	4cb5f299dd7413e0be1ad7af817ee614b23a18ae
ToppCell	facs-Heart-RV-3m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADRA1D NRXN1 BHLHE22	1.83e-04	184	27	3	31dbe6119a3bcd266ae5e9b340c853d9ff680dce
ToppCell	facs-Heart-RV-3m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADRA1D NRXN1 BHLHE22	1.83e-04	184	27	3	9c20b50f8d6ac689d41d5440c835f9db8d04758b
ToppCell	facs-Heart-LA-18m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADRA1D NRXN1 BHLHE22	1.89e-04	186	27	3	e2ba9f3518d87a44537a57a648df17ab98fbbb39
ToppCell	facs-Heart-LA-18m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADRA1D NRXN1 BHLHE22	1.89e-04	186	27	3	fda3415222f688ef5cd8de4b0b79daa2493c585f
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal-neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KCNC3 PURB BHLHE22	1.95e-04	188	27	3	1efbc99bcd6542e5d9fa91edb7c4295167914786
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Mesenchymal-stromal_related\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	KRT2 KRT3 KRT76	2.08e-04	192	27	3	8ad6678df89175c5a4a835c8566f1552df3c996e
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Mesenchymal-stromal_related-ICC\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	KRT2 KRT3 KRT76	2.08e-04	192	27	3	2f5378ea0b2fb2f672a36585d375f675983363a1
ToppCell	10x_3'_v2v3-Neoplastic-Differentiated-like-AC-like-AC-like-B\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	NPAS3 MSRB2 NRXN1	2.14e-04	194	27	3	68d15917ae222cba0ad9e716d29eebb6c5f00f69
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	NRXN1 SHISA7 USP24	2.31e-04	199	27	3	19a97e27a4758e794ce7246d295e112b47931a48
ToppCell	Neuronal-Inhibitory-iA-iA_3(VIP)-VIP_3-PCDH20-L1-2\|Neuronal / cells hierarchy compared to all cells using T-Statistic	NPAS3 ADRA1D GRIN2D	2.34e-04	200	27	3	1d67c5d2c617749b521e70879950dea2c9d076d6
ToppCell	Neuronal-Inhibitory-iA-iA_1(SST_PAX6)\|Neuronal / cells hierarchy compared to all cells using T-Statistic	NPAS3 ADRA1D GRIN2D	2.34e-04	200	27	3	d0167f96314be78b6d867bbcc6e4396071d931b8
ToppCell	Neuronal-Inhibitory-iA-iA_1(SST_PAX6)-SST-CHRNA4-L1\|Neuronal / cells hierarchy compared to all cells using T-Statistic	NPAS3 CBLC GRIN2D	2.34e-04	200	27	3	e2ced6eb1de9a526c34c7558b9c637854916e624
ToppCell	Neuronal-Inhibitory-iA-iA_1(SST_PAX6)-SST-CHRNA4\|Neuronal / cells hierarchy compared to all cells using T-Statistic	NPAS3 CBLC GRIN2D	2.34e-04	200	27	3	9bc924755e5a4c464408e6103b86bf1b4e8c58b5
ToppCell	Neuronal-Inhibitory-iA-iA_3(VIP)-VIP_3-PCDH20\|Neuronal / cells hierarchy compared to all cells using T-Statistic	NPAS3 ADRA1D GRIN2D	2.34e-04	200	27	3	26c7f2b0afe9e50f2a5c43918ad8e91d7553b72c
Disease	level of Sterol ester (27:1/20:3) in blood serum	NRXN1 USP24	1.17e-04	19	25	2	OBA_2045199
Disease	level of Sterol ester (27:1/16:0) in blood serum	CBLC USP24	2.21e-04	26	25	2	OBA_2045191
Disease	squamous cell lung carcinoma, family history of lung cancer	NPAS3 PURB	2.36e-03	85	25	2	EFO_0000708, EFO_0006953
Disease	descending aortic diameter	ARHGEF40 GDF7	2.52e-03	88	25	2	EFO_0021788
Disease	sleep duration, low density lipoprotein cholesterol measurement	CBLC USP24	2.69e-03	91	25	2	EFO_0004611, EFO_0005271
Disease	executive function measurement	DOC2A NPAS3 ADRA1D	3.83e-03	376	25	3	EFO_0009332
Disease	lean body mass	DOC2A NPAS3 ARHGEF40	3.92e-03	379	25	3	EFO_0004995
Disease	free cholesterol measurement, low density lipoprotein cholesterol measurement	CBLC USP24	5.99e-03	137	25	2	EFO_0004611, EFO_0008591
Disease	hemorrhoid	GDF7 HOXD11	6.86e-03	147	25	2	EFO_0009552
Disease	resting heart rate	ARHGEF40 WIPF1	7.04e-03	149	25	2	EFO_0004351
Disease	transient cerebral ischemia (biomarker_via_orthology)	NRXN1 HNRNPA2B1	7.79e-03	157	25	2	DOID:224 (biomarker_via_orthology)
Disease	Leukemia, Myelocytic, Acute	CBLC POU4F1	9.38e-03	173	25	2	C0023467
Disease	response to xenobiotic stimulus	ADRA1D NRXN1	1.03e-02	182	25	2	GO_0009410

Protein segments in the cluster

Peptide	Gene	Start	Entry
RGGGGGGQGAEGPPG	ARHGEF40	356	Q8TER5
GGGGPGGPGGSGDFL	CBLC	66	Q9ULV8
GGASVPPGGLGGGGG	BHLHE22	191	Q8NFJ8
PGVFGGPGSFGGPGG	KRT76	131	Q01546
GPGSFGGPGGFGPGG	KRT76	136	Q01546
GGPGGFGPGGFPGGI	KRT76	141	Q01546
GGAHDGPGGGGGPGG	POU4F1	141	Q01851
PGGGGGGPGGGLLGG	POU4F1	171	Q01851
ELGSPGGGGGGGGGG	NRXN1	11	P58400
FGGPGGVGGLGGPGG	KRT2	126	P35908
GVGGLGGPGGFGPGG	KRT2	131	P35908
GGPGGFGPGGYPGGI	KRT2	136	P35908
GSPGGFGPGGFPGGI	KRT3	156	P12035
GGGGAGPPVVGGGGG	OSBP	21	P22059
GGGGGGKARPPGGGA	FZD8	211	Q9H461
FPRGPGPEGGGGGGG	DOC2A	36	Q14183
GGPGGGGGGAGGYAP	HOXD11	91	P31277
NRGGGGFGAGPGPGG	PURB	151	Q96QR8
AGGPGGGAGGPGGGL	PURB	201	Q96QR8
PAGGGGGAGGAGGGP	KHSRP	16	Q92945
GAGDRGGGGPGGGGP	KHSRP	36	Q92945
GGGGGGGGGAPPDDL	TAL1	266	P17542
PVRSPGGGGGGGGGG	GDF7	36	Q7Z4P5
GAGGAGGAGGGPGPG	SHISA7	146	A6NL88
FPSPQGGGGGGGGGG	NPAS3	691	Q8IXF0
PAVGGVPGGAGGGGG	ADRA1D	41	P25100
GGGGGGGGGSVAPKP	ZNF384	176	Q8TF68
GGGGPGTGPGLGEAG	MSRB2	26	Q9Y3D2
GYGGGPGGGNFGGSP	HNRNPA2B1	246	P22626
PGGGNFGGSPGYGGG	HNRNPA2B1	251	P22626
PPLGEGGGGGGEGGG	SOGA3	161	Q5TF21
GGIGGGGGPPTGAGR	ZBTB4	576	Q9P1Z0
GGGGGSFGGGGPPGL	WIPF1	86	O43516
PGGGPRGDGGGDGGG	USP24	66	Q9UPU5
GGGAGGPPGGAGGAG	KCNC3	251	Q14003
GGAGGPGGGLGGARP	GRIN2D	36	O15399