Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
MousePheno	increased fear-related response	SLC9A5 SHANK3 TRPC5	1.48e-05	19	36	3	MP:0003459
MousePheno	decreased cardiac muscle relaxation	HRC PKN1	6.42e-05	5	36	2	MP:0020419
Domain	VWFA	INTS6L VWA1 HMCN2	1.15e-03	82	47	3	PS50234
Domain	VWA	INTS6L VWA1 HMCN2	1.23e-03	84	47	3	SM00327
Domain	PAS	NPAS3 PDE8B	1.79e-03	25	47	2	PF00989
Domain	PAS_fold	NPAS3 PDE8B	1.79e-03	25	47	2	IPR013767
Domain	VWF_A	INTS6L VWA1 HMCN2	1.98e-03	99	47	3	IPR002035
Domain	Ank_2	AGAP11 ANKRD50 SHANK3 TRPC5	2.07e-03	215	47	4	PF12796
Domain	-	SHANK3 PPFIA4 GABPA	2.40e-03	106	47	3	1.10.150.50
Domain	PAS	NPAS3 PDE8B	2.93e-03	32	47	2	SM00091
Domain	SAM/pointed	SHANK3 PPFIA4 GABPA	3.18e-03	117	47	3	IPR013761
Domain	Cadherin	FREM3 PCDHGA10 PCDHGA2	3.26e-03	118	47	3	IPR002126
Domain	PAS	NPAS3 PDE8B	3.30e-03	34	47	2	IPR000014
Domain	PAS	NPAS3 PDE8B	3.30e-03	34	47	2	PS50112
Domain	-	AGAP11 ANKRD50 SHANK3 TRPC5	3.46e-03	248	47	4	1.25.40.20
Domain	ANK	AGAP11 ANKRD50 SHANK3 TRPC5	3.61e-03	251	47	4	SM00248
Domain	ANK_REPEAT	AGAP11 ANKRD50 SHANK3 TRPC5	3.71e-03	253	47	4	PS50088
Domain	Ankyrin_rpt-contain_dom	AGAP11 ANKRD50 SHANK3 TRPC5	3.77e-03	254	47	4	IPR020683
Domain	ANK_REP_REGION	AGAP11 ANKRD50 SHANK3 TRPC5	3.77e-03	254	47	4	PS50297
Domain	Cadherin_tail	PCDHGA10 PCDHGA2	3.90e-03	37	47	2	PF15974
Domain	Cadherin_CBD	PCDHGA10 PCDHGA2	3.90e-03	37	47	2	IPR031904
Domain	Ankyrin_rpt	AGAP11 ANKRD50 SHANK3 TRPC5	4.21e-03	262	47	4	IPR002110
Domain	Cadherin_C	PCDHGA10 PCDHGA2	5.01e-03	42	47	2	IPR032455
Domain	Cadherin_C_2	PCDHGA10 PCDHGA2	5.01e-03	42	47	2	PF16492
Domain	TPR_2	TTC8 TTC5	7.03e-03	50	47	2	PF07719
Domain	TPR_2	TTC8 TTC5	7.03e-03	50	47	2	IPR013105
Pubmed	Novel testis- and embryo-specific isoforms of the phosphofructokinase-1 muscle type gene.	SENP1 PFKM	1.87e-06	2	48	2	15020257
Pubmed	Gatad2b, associated with the neurodevelopmental syndrome GAND, plays a critical role in neurodevelopment and cortical patterning.	NEFM SATB2	6.67e-05	9	48	2	38238293
Pubmed	Subtle Roles of Down Syndrome Cell Adhesion Molecules in Embryonic Forebrain Development and Neuronal Migration.	NEFM SATB2	8.33e-05	10	48	2	33585465
Pubmed	Behavioral phenotypes of genetic mouse models of autism.	NLGN1 SHANK3	1.02e-04	11	48	2	26403076
Pubmed	Igf1R/InsR function is required for axon extension and corpus callosum formation.	NEFM SATB2	1.02e-04	11	48	2	31318893
Pubmed	Nephrocystin proteins NPHP5 and Cep290 regulate BBSome integrity, ciliary trafficking and cargo delivery.	TTC8 MARCHF7	1.02e-04	11	48	2	25552655
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	GEMIN5 CCDC50 MARCHF7 TYW1 SLC39A10 ANKRD50 MAP4K3 ZBTB24	1.08e-04	1084	48	8	11544199
Pubmed	Gli3 controls subplate formation and growth of cortical axons.	NEFM SATB2	1.22e-04	12	48	2	22903314
Pubmed	Af9/Mllt3 interferes with Tbr1 expression through epigenetic modification of histone H3K79 during development of the cerebral cortex.	NEFM SATB2	1.22e-04	12	48	2	20348416
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	NFE2L3 NEFM CCDC50 TRIM43 PFKM PCDHGA10 PPFIA4 PCDHGA2 GABPA	1.37e-04	1442	48	9	35575683
Pubmed	Differential impacts of Cntnap2 heterozygosity and Cntnap2 null homozygosity on axon and myelinated fiber development in mouse.	NEFM SATB2	1.44e-04	13	48	2	36793543
Pubmed	Translational animal models of autism and neurodevelopmental disorders.	NLGN1 SHANK3	1.68e-04	14	48	2	23226954
Pubmed	Ablation of CNTN2+ Pyramidal Neurons During Development Results in Defects in Neocortical Size and Axonal Tract Formation.	NEFM SATB2	1.68e-04	14	48	2	31749685
Pubmed	Mllt11 Regulates Migration and Neurite Outgrowth of Cortical Projection Neurons during Development.	NEFM SATB2	2.21e-04	16	48	2	35379703
Pubmed	Dynamic expression of the mouse orthologue of the human amyotropic lateral sclerosis associated gene C9orf72 during central nervous system development and neuronal differentiation.	NEFM SATB2	2.50e-04	17	48	2	27476503
Pubmed	MEF2C regulates cortical inhibitory and excitatory synapses and behaviors relevant to neurodevelopmental disorders.	NLGN1 SHANK3	2.50e-04	17	48	2	27779093
Pubmed	Loss of transforming growth factor-beta 2 leads to impairment of central synapse function.	NEFM NLGN1	2.81e-04	18	48	2	18854036
Pubmed	Neural Stem Cells Direct Axon Guidance via Their Radial Fiber Scaffold.	NEFM SATB2	2.81e-04	18	48	2	32707082
Pubmed	Fgfr2 is required for the development of the medial prefrontal cortex and its connections with limbic circuits.	NEFM SATB2	3.14e-04	19	48	2	20410112
Pubmed	mSYD1A, a mammalian synapse-defective-1 protein, regulates synaptogenic signaling and vesicle docking.	NLGN1 PPFIA4	3.49e-04	20	48	2	23791195
Pubmed	Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	SLC39A10 ANKRD50 TMCC3	3.96e-04	103	48	3	10574462
Pubmed	Pyramidal neurons form active, transient, multilayered circuits perturbed by autism-associated mutations at the inception of neocortex.	NFE2L3 SATB2	4.63e-04	23	48	2	37071993
Pubmed	Distinct dynein complexes defined by DYNLRB1 and DYNLRB2 regulate mitotic and male meiotic spindle bipolarity.	MLH1 CENPE	4.63e-04	23	48	2	36973253
Pubmed	Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.	TTC8 PFKM ANKRD50 CEP72 ZBTB24 ZUP1	5.29e-04	742	48	6	26871637
Pubmed	Disruption of the ATXN1-CIC complex causes a spectrum of neurobehavioral phenotypes in mice and humans.	SATB2 SHANK3	5.48e-04	25	48	2	28288114
Pubmed	Ccm3, a gene associated with cerebral cavernous malformations, is required for neuronal migration.	NEFM SATB2	5.48e-04	25	48	2	24595293
Pubmed	Genome-wide association identifies multiple ulcerative colitis susceptibility loci.	SATB2 CEP72	5.93e-04	26	48	2	20228799
Pubmed	Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.	NEFM NLGN1 AGAP11 SHANK3	6.14e-04	281	48	4	28706196
Pubmed	Regulation of archicortical arealization by the transcription factor Zbtb20.	NEFM SATB2	6.89e-04	28	48	2	22689450
Pubmed	Gli3 controls corpus callosum formation by positioning midline guideposts during telencephalic patterning.	NEFM SATB2	7.92e-04	30	48	2	23042737
Pubmed	Neurotransmitter release regulated by a MALS-liprin-alpha presynaptic complex.	NLGN1 PPFIA4	7.92e-04	30	48	2	16186258
Pubmed	Expansion of the piriform cortex contributes to corticothalamic pathfinding defects in Gli3 conditional mutants.	NEFM SATB2	8.45e-04	31	48	2	24014668
Pubmed	Corticothalamic Projection Neuron Development beyond Subtype Specification: Fog2 and Intersectional Controls Regulate Intraclass Neuronal Diversity.	NFE2L3 SATB2	8.45e-04	31	48	2	27321927
Pubmed	Essential roles for the splicing regulator nSR100/SRRM4 during nervous system development.	NEFM SATB2	8.45e-04	31	48	2	25838543
Pubmed	The autophagy-inducing kinases, ULK1 and ULK2, regulate axon guidance in the developing mouse forebrain via a noncanonical pathway.	NEFM SATB2	8.45e-04	31	48	2	29099309
Pubmed	Recurrent rearrangements in synaptic and neurodevelopmental genes and shared biologic pathways in schizophrenia, autism, and mental retardation.	NLGN1 SHANK3	8.45e-04	31	48	2	19736351
Pubmed	Transcription factors Bcl11a and Bcl11b are required for the production and differentiation of cortical projection neurons.	NFE2L3 SATB2	1.02e-03	34	48	2	34963132
Pubmed	Rewiring of RSK-PDZ Interactome by Linear Motif Phosphorylation.	SHANK3 PDZRN4	1.02e-03	34	48	2	30726710
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	CCDC50 FAM184A SENP1 PFKM CENPE MAP4K3	1.09e-03	853	48	6	28718761
Interaction	KIF7 interactions	NEFM FAM184A SLC39A10 CEP72 SHANK3 ZUP1	1.25e-06	146	48	6	int:KIF7
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	PFKM CENPE TRPC5 HSPB6	6.70e-04	181	40	4	694
GeneFamily	Ankyrin repeat domain containing	ANKRD13D AGAP11 ANKRD50 SHANK3	1.96e-03	242	40	4	403
ToppCell	Sigmoid-(1)_T_cell-(14)_Tcm\|Sigmoid / shred on region, Cell_type, and subtype	NLRC5 FAM184A MAP4K3 PDE8B PCDHGA2	2.36e-06	199	48	5	ec454fa22fb7f50a947bdf4c4bb6f0ba13f62b4c
ToppCell	Sigmoid-T_cell-Tcm\|Sigmoid / Region, Cell class and subclass	NLRC5 FAM184A MAP4K3 PDE8B PCDHGA2	2.36e-06	199	48	5	f7c729eaa3c8fd5a05cb6f79cac9b8f199c8092b
ToppCell	Sigmoid-T_cell-Tcm\|T_cell / Region, Cell class and subclass	NLRC5 FAM184A MAP4K3 PDE8B PCDHGA2	2.36e-06	199	48	5	acdf95f4d58df47690f4ae254245bc618f9ac07e
ToppCell	kidney_cells-Adult_normal_reference-Mesenchymal--glomerular_mesenchymal_cell-Renin-positive_Juxtaglomerular_Granular_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	HRC AGAP11 PPFIA4 HSPB6	2.79e-05	162	48	4	c7114e24cb5525abb9780ca3d35dbcc4eabd4b64
ToppCell	kidney_cells-Adult_normal_reference-Mesenchymal--glomerular_mesenchymal_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	HRC AGAP11 PPFIA4 HSPB6	2.79e-05	162	48	4	f1851a173d3bcca2981d934161ec85d1cc0af5a2
ToppCell	kidney_cells-Adult_normal_reference-Mesenchymal-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	HRC AGAP11 PPFIA4 HSPB6	2.79e-05	162	48	4	5d902bb31e691aea9749617cc88303c2448f24b8
ToppCell	TCGA-Thryoid-Primary_Tumor-Thyroid_Papillary_Carcinoma-Classical-8\|TCGA-Thryoid / Sample_Type by Project: Shred V9	NPAS3 TRPC5 ARHGAP19 PDZRN4	3.21e-05	168	48	4	00646601548b0fee42ae16bfa5e93603bc7c5129
ToppCell	368C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_3\|368C / Donor, Lineage, Cell class and subclass (all cells)	INTS6L MAP4K3 ZBTB24 TMCC3	4.11e-05	179	48	4	10c7d371937d9d93c12c8d3465430ef9e0c2ec81
ToppCell	droplet-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l30\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	NPAS3 NLGN1 VWA1 PFKM	4.87e-05	187	48	4	8e8b147258982b359447add5027318f5b6d51963
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	NPAS3 NFE2L3 PPFIA4 ARHGAP19	4.87e-05	187	48	4	24c2a3962da364e46e98abeab5f8234376fa26bb
ToppCell	droplet-Heart-nan-18m-Mesenchymal-cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HRC PFKM HSPB6 PDZRN4	5.40e-05	192	48	4	0bf99e029a06151092db1e8a0dcb45f4e688e771
ToppCell	droplet-Heart-nan-18m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HRC PFKM HSPB6 PDZRN4	5.40e-05	192	48	4	d766221acfce30cbf2c60b3ae40f6744968b952c
ToppCell	5'-GW_trimst-2-SmallIntestine-Mesenchymal-myocytic-SMC_(PART1/CAPN3+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	VWA1 HMCN2 HSPB6 PDZRN4	5.62e-05	194	48	4	d2bafd31bb8333f66b6c714944bceb2f1aa11740
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_2_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	NLGN1 HMCN2 HSPB6 PDZRN4	5.73e-05	195	48	4	ff0aa455e9844a6d7ae57ff59fb6cea825cf1fc2
ToppCell	Fibroblasts-CD34+_Fibroblasts\|Fibroblasts / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	FAM184A NLGN1 HSPB6 PDZRN4	5.73e-05	195	48	4	c6b5249ac8714b1b701cde31d00ab53f28355c36
ToppCell	Kidney-Mesangial\|Kidney / Skin and Kidney Cells in Lupus Nephritis Patients.	HRC AGAP11 SLC9A5 HSPB6	5.85e-05	196	48	4	2b2cbe7f96213b7ff50442593f31820d17a2ae94
ToppCell	Parenchymal-10x3prime_v2-Stromal-Myofibroblastic-Muscle_perivascular_immune_recruiting\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	HRC SENP1 GABPA HSPB6	6.33e-05	200	48	4	a372ef3f9e6ff6e3c3376d6e10182977c5067788
ToppCell	Control_saline-Mesenchymal_myocytic-Pericyte-Pericyte_2\|Control_saline / Treatment groups by lineage, cell group, cell type	NFE2L3 ANKRD50 MAP4K3 PDE8B	6.33e-05	200	48	4	bc8949eb34482aca166c4602ff6ab876cb4c2c3c
Disease	childhood trauma measurement, alcohol consumption measurement	MARCHF7 PCDHGA10 PCDHGA2	1.88e-04	71	46	3	EFO_0007878, EFO_0007979
Disease	mental development measurement	PCDHGA10 PCDHGA2	6.97e-04	25	46	2	EFO_0008230
Disease	autism spectrum disorder (implicated_via_orthology)	NLGN1 SHANK3 TRPC5	1.73e-03	152	46	3	DOID:0060041 (implicated_via_orthology)
Disease	ciliopathy (implicated_via_orthology)	TTC8 MAP4K3	1.79e-03	40	46	2	DOID:0060340 (implicated_via_orthology)
Disease	major depressive episode	SATB2 FREM3	2.46e-03	47	46	2	EFO_0007634
Disease	motion sickness	NLGN1 PDZRN4	2.56e-03	48	46	2	EFO_0006928
Disease	cholesteryl esters to total lipids in small VLDL percentage	NFE2L3 NLRC5	2.67e-03	49	46	2	EFO_0022256
Disease	cholesterol to total lipids in small VLDL percentage	NFE2L3 NLRC5	2.89e-03	51	46	2	EFO_0022242
Disease	response to reverse transcriptase inhibitor, HIV-1 infection, peripheral neuropathy	NFE2L3 NEFM	3.23e-03	54	46	2	EFO_0000180, EFO_0003100, GO_0061479
Disease	Nonorganic psychosis	NPAS3 ZSCAN31	5.22e-03	69	46	2	C0349204

Protein segments in the cluster

Peptide	Gene	Start	Entry
VTLEIHHHITERDAD	AGAP11	6	Q8TF27
ELEAALHSHQHDIEQ	ANKRD13D	21	Q6ZTN6
DHTLAHSLQEQEIEH	CCDC50	26	Q8IVM0
EIVEHLLDHGAEVNH	ANKRD50	691	Q9ULJ7
EVTAELHHTHKELDD	CEP72	501	Q9P209
EISEAKHDHHLVEDL	C22orf42	156	Q6IC83
DLQEELRHREHHISE	FAM184A	871	Q8NB25
HHISELDKEVQHLHE	FAM184A	881	Q8NB25
SVRLHELEAHVEHCD	PDZRN4	91	Q6ZMN7
LERSLDREEEAVHHL	PCDHGA2	196	Q9Y5H1
LVHTDATIIHDGHEE	INTS6L	666	Q5JSJ4
EELHQRGHVAHLEDD	MAP4K3	401	Q8IVH8
HVEVHARHEERPDEH	HSPB6	96	O14558
PDAHHAESEAHLVEE	GABPA	126	Q06546
KVHLLSTDHEEEGEH	HMCN2	216	Q8NDA2
EEQHHHKGRLSEEIE	PPFIA4	471	O75335
EHSLDREEEAIHHLV	PCDHGA10	201	Q9Y5H3
EIDLDTSDHAHLEHI	PFKM	756	P08237
DHCHEAIEITSDDHV	PDE8B	276	O95263
REKHEAVDHSSQHEE	NFE2L3	196	Q9Y4A8
DHECESIHPHEVVLR	NLGN1	781	Q8N2Q7
LHHATLHFRSNEEEE	NLRC5	1201	Q86WI3
VADILAHEIHVLEKH	PON2	236	Q15165
EDFDIHELHRAHANE	MARCHF7	616	Q9H992
HEDLGHDHVSHLDIL	SLC39A10	101	Q9ULF5
HIHLKEHQETIDELR	CENPE	1241	Q02224
QHLHVEDVDTHQDEL	FREM3	1091	P0C091
HHPIEEAAEEHREKL	TRIM43	126	Q96BQ3
LEDQLHDLTDLHQHE	TMCC3	336	Q9ULS5
RELRETEHLLHDENE	MTRF1L	76	Q9UGC7
ERDVIYEEESRHHHS	SATB2	551	Q9UPW6
QEREHSVHDSVELHL	SENP1	376	Q9P0U3
ELHEHTFDHILAAVE	SLC9A5	471	Q14940
HAEDVEGIRHSHLDL	NPAS3	371	Q8IXF0
EELRHHFRVEHAVAE	PKN1	216	Q16512
HHHHHRVPREEDEEV	HRC	416	P23327
KHEVHFLHEESILER	MLH1	311	P40692
AEKHLHFVDVDDLHI	VWA1	186	Q6PCB0
HHENDVKTIHLEDVV	TTC8	201	Q8TAM2
HEHGHSEVLLEDVEH	ZSCAN31	131	Q96LW9
HLGEHRDRFEDHEIE	SHANK3	1681	Q9BYB0
EVIHRLRGHDDEIHS	GEMIN5	186	Q8TEQ6
LRQLRTDTEDEHSHH	TTC5	146	Q8N0Z6
HQEETQHHTEEALRE	ARHGAP19	361	Q14CB8
EHLHAHQEQTEELHL	ZBTB24	646	O43167
HILQEHVDLHLEENS	ZUP1	206	Q96AP4
EIILNHRDDHSEELD	TRPC5	266	Q9UL62
REEGSHEQDELHHRD	TYW1	271	Q9NV66
VQLDSDHLEEDIHRL	NEFM	171	P07197