Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionhyalurononglucosaminidase activity

HYAL4 HYAL2 SPAM1

7.19e-089203GO:0004415
GeneOntologyMolecularFunctionhexosaminidase activity

HYAL4 HYAL2 SPAM1

5.79e-0717203GO:0015929
GeneOntologyMolecularFunctionhydrolase activity, hydrolyzing O-glycosyl compounds

HYAL4 HYAL2 SPAM1

1.43e-04103203GO:0004553
GeneOntologyMolecularFunctionhydrolase activity, acting on glycosyl bonds

HYAL4 HYAL2 SPAM1

3.83e-04144203GO:0016798
GeneOntologyMolecularFunctionABC-type transporter activity

ABCB6 ABCA2

1.09e-0349202GO:0140359
GeneOntologyMolecularFunctionpeptidase regulator activity

SSPOP ABCA2 PRNP

2.04e-03257203GO:0061134
GeneOntologyMolecularFunctionATPase-coupled transmembrane transporter activity

ABCB6 ABCA2

5.26e-03109202GO:0042626
GeneOntologyMolecularFunctionenzyme inhibitor activity

SSPOP HYAL2 PRNP

8.89e-03435203GO:0004857
GeneOntologyMolecularFunctionactive transmembrane transporter activity

ABCB6 ABCA2 SLC34A3

1.14e-02477203GO:0022804
GeneOntologyBiologicalProcesshyaluronan catabolic process

HYAL4 HYAL2 SPAM1

6.30e-0718203GO:0030214
GeneOntologyBiologicalProcessglycosaminoglycan catabolic process

HYAL4 HYAL2 SPAM1

3.80e-0632203GO:0006027
GeneOntologyBiologicalProcessaminoglycan catabolic process

HYAL4 HYAL2 SPAM1

6.44e-0638203GO:0006026
GeneOntologyBiologicalProcesshyaluronan metabolic process

HYAL4 HYAL2 SPAM1

7.53e-0640203GO:0030212
GeneOntologyBiologicalProcessmucopolysaccharide metabolic process

HYAL4 HYAL2 SPAM1

1.19e-04100203GO:1903510
GeneOntologyBiologicalProcessintracellular copper ion homeostasis

ABCB6 PRNP

1.68e-0420202GO:0006878
GeneOntologyBiologicalProcessglycosaminoglycan metabolic process

HYAL4 HYAL2 SPAM1

2.09e-04121203GO:0030203
GeneOntologyBiologicalProcesscopper ion homeostasis

ABCB6 PRNP

2.23e-0423202GO:0055070
GeneOntologyBiologicalProcessaminoglycan metabolic process

HYAL4 HYAL2 SPAM1

2.70e-04132203GO:0006022
GeneOntologyCellularComponentATP-binding cassette (ABC) transporter complex

ABCB6 ABCA2

1.44e-056212GO:0043190
DomainHyaluronidase

HYAL4 HYAL2 SPAM1

1.22e-085213IPR018155
DomainGlyco_hydro_56

HYAL4 HYAL2 SPAM1

1.22e-085213PF01630
DomainHyaluronidase_PH20

HYAL4 SPAM1

1.20e-062212IPR001439
Domain-

HYAL4 HYAL2 SPAM1

1.37e-05422133.20.20.70
DomainAldolase_TIM

HYAL4 HYAL2 SPAM1

1.58e-0544213IPR013785
DomainGlycoside_hydrolase_SF

HYAL4 HYAL2 SPAM1

2.77e-0553213IPR017853
DomainEMI

EMILIN2 SSPOP

1.62e-0417212PS51041
DomainABC_transporter_CS

ABCB6 ABCA2

1.01e-0342212IPR017871
DomainABC_TRANSPORTER_2

ABCB6 ABCA2

1.32e-0348212PS50893
DomainABC_tran

ABCB6 ABCA2

1.32e-0348212PF00005
DomainABC_TRANSPORTER_1

ABCB6 ABCA2

1.37e-0349212PS00211
DomainABC_transporter-like

ABCB6 ABCA2

1.43e-0350212IPR003439
DomainTSP_1

SSPOP ISM1

2.26e-0363212PF00090
DomainTSP1_rpt

SSPOP ISM1

2.40e-0365212IPR000884
DomainTSP1

SSPOP ISM1

2.40e-0365212PS50092
DomainTSP1

SSPOP ISM1

2.40e-0365212SM00209
DomainEGF_1

HYAL4 SSPOP HYAL2

2.79e-03255213PS00022
DomainEGF_2

HYAL4 SSPOP HYAL2

3.11e-03265213PS01186
DomainAAA+_ATPase

ABCB6 ABCA2

1.13e-02144212IPR003593
DomainAAA

ABCB6 ABCA2

1.13e-02144212SM00382
PathwayKEGG_MEDICUS_REFERENCE_DERMATAN_SULFATE_DEGRADATION

HYAL4 HYAL2 SPAM1

8.13e-088173M47607
PathwayKEGG_GLYCOSAMINOGLYCAN_DEGRADATION

HYAL4 HYAL2 SPAM1

1.91e-0621173M3624
PathwayWP_GLYCOSAMINOGLYCAN_DEGRADATION

HYAL4 HYAL2

1.84e-0417172M39832
Pubmed

Human hyaluronidases: electrophoretic multiple forms in somatic tissues and body fluids. Evidence for conserved hyaluronidase potential N-glycosylation sites in different mammalian species.

HYAL4 HYAL2

1.15e-06322210989127
Pubmed

Sperm dysfunction in the Rb(6.16)- and Rb(6.15)-bearing mice revisited: involvement of Hyalp1 and Hyal5.

HYAL4 SPAM1

1.15e-06322216078272
Pubmed

Identification of a hyaluronidase, Hyal5, involved in penetration of mouse sperm through cumulus mass.

HYAL4 SPAM1

1.15e-06322216330764
Pubmed

Expression analysis of six paralogous human hyaluronidase genes clustered on chromosomes 3p21 and 7q31.

HYAL4 SPAM1

2.29e-06422210493834
Cytoband7q31.3

HYAL4 SPAM1

2.29e-05152227q31.3
Cytoband9q34

ABCA2 SLC34A3

3.09e-04542229q34
Cytoband20p13

TMEM239 PRNP

1.10e-0310222220p13
CytobandEnsembl 112 genes in cytogenetic band chr20p13

TMEM239 PRNP

1.59e-03123222chr20p13
CytobandEnsembl 112 genes in cytogenetic band chr7q31

HYAL4 SPAM1

2.05e-03140222chr7q31
CytobandEnsembl 112 genes in cytogenetic band chr9q34

ABCA2 SLC34A3

1.05e-02325222chr9q34
GeneFamilyADAM metallopeptidase domain containing|CD molecules

ART1 PRNP

2.71e-02394122471
CoexpressionNABA_MATRISOME

HYAL4 EMILIN2 SSPOP MUC21 HYAL2 SPAM1 ISM1

8.82e-061008217MM17056
CoexpressionNABA_MATRISOME

HYAL4 EMILIN2 SSPOP MUC21 HYAL2 SPAM1 ISM1

9.91e-061026217M5889
ToppCellStriatum-Macroglia-OLIGODENDROCYTE-O2|Striatum / BrainAtlas - Mouse McCarroll V32

EMILIN2 ABCB6 SLC34A3

6.70e-0675223a34bb5997d056727abce1095f762f94b7818c105
ToppCellStriatum-Macroglia-OLIGODENDROCYTE-O2-Trf-Oligodendrocyte.Trf.Klk6_(Klk6)|Striatum / BrainAtlas - Mouse McCarroll V32

EMILIN2 ABCB6 SLC34A3

6.70e-0675223dfc7007f3ecf2b340dbbca519db013c72b3cbbf4
ToppCellStriatum-Macroglia-OLIGODENDROCYTE-O2-Trf-Oligodendrocyte.Trf.Klk6_(Klk6)-|Striatum / BrainAtlas - Mouse McCarroll V32

EMILIN2 ABCB6 SLC34A3

6.70e-06752230e25dcbb4194c2f96c9591020f5bddd41542c2b5
ToppCellStriatum-Macroglia-OLIGODENDROCYTE-O2-Trf|Striatum / BrainAtlas - Mouse McCarroll V32

EMILIN2 ABCB6 SLC34A3

6.70e-06752239501cfd3c5ec820f363e9a52181de34bac725036
ToppCellGlobus_pallidus-Macroglia-OLIGODENDROCYTE-O1|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

EMILIN2 SSPOP SLC34A3

2.61e-05118223d0dd5c882cd9e0a5eb0cb08e47877292126bd4ae
ToppCellGlobus_pallidus-Macroglia-OLIGODENDROCYTE-O1-Trf|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

EMILIN2 SSPOP SLC34A3

2.61e-051182234283699cb3ca7a112faa07727dfdc0b0a67fb779
ToppCellGlobus_pallidus-Macroglia-OLIGODENDROCYTE-O2-Trf|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

EMILIN2 SSPOP SLC34A3

2.88e-0512222340f983623c990203df4ba997e296231489d51012
ToppCellFrontal_cortex-Macroglia-OLIGODENDROCYTE|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

EMILIN2 SSPOP SLC34A3

2.88e-05122223ecd0e54dd829201290212ea2ff7c8e7eec19c0e9
ToppCellGlobus_pallidus-Macroglia-OLIGODENDROCYTE-O2|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

EMILIN2 SSPOP SLC34A3

2.88e-05122223d4152c45dfbb979ddf8380b4896db753a79cad9e
ToppCellFrontal_cortex-Macroglia-OLIGODENDROCYTE-O2|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

EMILIN2 SSPOP SLC34A3

2.88e-051222232880f25d10a7765e55a2aa20c7a6ef74cea19c4d
ToppCellFrontal_cortex-Macroglia-OLIGODENDROCYTE-O2-Tnr|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

EMILIN2 SSPOP SLC34A3

2.88e-05122223cffd7730bda90828efc0def452cabb44cf93ab48
ToppCellPosterior_cortex-Macroglia-OLIGODENDROCYTE|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

EMILIN2 SSPOP SLC34A3

3.03e-051242239f169fa17be1842a6bd83778ff30465a740edd5f
ToppCellGlobus_pallidus-Macroglia-OLIGODENDROCYTE|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

EMILIN2 SSPOP SLC34A3

3.41e-0512922398a5f24de72d2ae6a57787226b2e523ddd13b2c5
ToppCellHippocampus-Macroglia-OLIGODENDROCYTE-O2-Trf|Hippocampus / BrainAtlas - Mouse McCarroll V32

EMILIN2 SSPOP SLC34A3

3.65e-05132223dc6edfa821a1cdc645668b0af5ba5ff80dee10bd
ToppCellHippocampus-Macroglia-OLIGODENDROCYTE-O2|Hippocampus / BrainAtlas - Mouse McCarroll V32

EMILIN2 SSPOP SLC34A3

3.65e-0513222360ced08bda5efc95a6f116cd0c6d1a779d99ed38
ToppCellHippocampus-Macroglia-OLIGODENDROCYTE|Hippocampus / BrainAtlas - Mouse McCarroll V32

EMILIN2 SSPOP SLC34A3

4.08e-051372235e97480f014f1d9267e8126f1d0e58acd22f36aa
ToppCellkidney_cells-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

PRNP SLC34A3 DNMT3A

4.83e-0514522347a3bb973a508d3097213a2d86ad1ce697af9bae
ToppCellEpithelial-Epithelial-C_(AT2)|Epithelial / shred on cell class and cell subclass (v4)

KCNC3 DMTF1 PRNP

8.15e-05173223f57cbf5bd2a9e5db47b4919e9cd5e50781c1a990
ToppCellEpithelial-C_(AT2)|World / shred on cell class and cell subclass (v4)

KCNC3 DMTF1 PRNP

1.01e-04186223b7b1763fc52b4485d843a4a6727055e6c95ebad3
ToppCellfacs-Lung-nan-3m-Mesenchymal-Myofibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ART1 PRNP ISM1

1.08e-04190223834218fcc59df5e7e52de154272f3d55d81d0dac
ToppCellfacs-Lung-nan-3m-Mesenchymal-pulmonary_interstitial_fibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ART1 PRNP ISM1

1.08e-04190223c7bd087f36321cec61b98657433b4d19d135791f
DrugAC1L98W1

HYAL4 HYAL2 SPAM1

2.70e-094213CID000440207
DrugFolin Marenzi reagent

HYAL4 HYAL2 PRNP SPAM1

1.89e-0832214CID000452313
Drugxanthan

HYAL4 HYAL2 SPAM1 FDXR

3.09e-0836214CID000007107
DrugGH 9

HYAL4 HYAL2 SPAM1

1.11e-0711213CID005488162
Drugthiocarbohydrazide

HYAL4 HYAL2 SPAM1

2.45e-0714213CID002724189
Drugetidocaine

HYAL4 HYAL2 SPAM1

5.47e-0718213CID000037497
Drugpyron

HYAL4 HYAL2 SPAM1

6.49e-0719213CID000041463
Drug2-aminoacridone

HYAL4 HYAL2 SPAM1

8.90e-0721213CID000121965
Drugsodium thiosulfate

HYAL4 HYAL2 SPAM1

1.35e-0624213CID000061475
Drugiduronic acid

HYAL4 HYAL2 SPAM1 ISM1

1.68e-0696214CID000018845
DrugTannins

HYAL4 HYAL2 SPAM1

4.73e-0636213CID000250395
Drugbupivacaine

HYAL4 HYAL2 SPAM1 ISM1

4.82e-06125214CID000002474
DrugS-ropivacaine

HYAL4 HYAL2 SPAM1

6.54e-0640213CID000071273
Drugcetylpyridinium chloride

HYAL4 HYAL2 SPAM1

8.74e-0644213CID000002683
Drugtrigalacturonate

HYAL4 HYAL2 SPAM1

1.29e-0550213CID000439239
Drugmepivacaine

HYAL4 HYAL2 SPAM1

1.37e-0551213CID000004062
DrugAC1L3D72

HYAL4 SPAM1

1.70e-057212CID000113417
DrugSurfynol

HYAL4 SPAM1

2.91e-059212CID000061018
DrugVincamine [1617-90-9]; Up 200; 11.2uM; PC3; HT_HG-U133A

ART1 ABCA2 DNMT3A KIAA0319L

3.02e-051992143784_UP
DrugAC1L8TZY

HYAL4 HYAL2 SPAM1

4.55e-0576213CID000408095
Drugruthenium

HYAL4 HYAL2 SPAM1

8.59e-0594213CID000023950
DrugNSC-17454

SPAM1 FDXR

1.68e-0421212CID003259967
DrugNSC3364

ABCA2 PRNP SPAM1

1.69e-04118213CID000025439
Drug6-Bromomannitol

ART1 PRNP

1.85e-0422212CID000027283
DiseaseKeloid

HYAL2 SPAM1

5.90e-0517202EFO_0004212
Diseasetreatment-resistant hypertension

TAF1A DNMT3A

2.46e-03109202EFO_1002006
Diseaseanthropometric measurement

DMTF1 DNMT3A

5.72e-03168202EFO_0004302

Protein segments in the cluster

PeptideGeneStartEntry
RGFSWWPGRIVSWWM

DNMT3A

301

Q9Y6K1
MASRCWRWWGWSAWP

FDXR

1

P22570
WRWWGWSAWPRTRLP

FDXR

6

P22570
WWWLGSRRWHPQSVE

PRNP

56

F7VJQ1
VSWNSPQWWWARADL

ABCB6

166

Q9NP58
WSSVRSPQWLRSKWW

DMTF1

371

Q9Y222
WLPVRLRSWAWLPVW

SLC34A3

541

Q8N130
VIDWEDWRPVWVRNW

HYAL2

131

Q12891
RWSPNWFWRRPVSSI

MUC21

541

Q5SSG8
WNWASWRQSPPRAAL

KIAA0319L

156

Q8IZA0
WGWVDCWEVPRAWDS

C19orf85

196

A0A1B0GUS0
WEYWRPQWARNWNSK

HYAL4

146

Q2M3T9
WLGSGRTEAWEWSWP

ABCA2

936

Q9BZC7
RTEAWEWSWPWARTP

ABCA2

941

Q9BZC7
DWEEWRPTWARNWKP

SPAM1

146

P38567
MWQPRRPWPRVPWRW

EMILIN2

1

Q9BXX0
WRWWQRLLPWRLLQA

DNAJC30

6

Q96LL9
WSVPSPDWRAWWQRS

ISM1

151

B1AKI9
PGGWSRWSPWSWCDR

SSPOP

4006

A2VEC9
AWVQEEWNSRKNWWP

TAF1A

366

Q15573
LPTPESAARDRWQWW

TLCD2

26

A6NGC4
PWSAWVTRHGWVRWW

TMEM239

66

Q8WW34
WVRWWVSHMPPSWIQ

TMEM239

76

Q8WW34
PSWIQWWSTSNWRQP

TMEM239

86

Q8WW34
GTWWRRWQPRVWALF

KCNC3

266

Q14003
WQERQARWPEWSLSP

ART1

86

P52961