Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionprotein domain specific binding

NF2 LYN KIT PRKDC CFTR

4.66e-04875165GO:0019904
GeneOntologyMolecularFunctionABC-type transporter activity

ABCA13 CFTR

6.93e-0449162GO:0140359
GeneOntologyMolecularFunctionATPase-coupled transmembrane transporter activity

ABCA13 CFTR

3.37e-03109162GO:0042626
GeneOntologyBiologicalProcesspositive regulation of mast cell proliferation

LYN KIT

8.45e-066162GO:0070668
GeneOntologyBiologicalProcessmast cell proliferation

LYN KIT

2.02e-059162GO:0070662
GeneOntologyBiologicalProcessregulation of mast cell proliferation

LYN KIT

2.02e-059162GO:0070666
GeneOntologyBiologicalProcessregulation of tyrosine phosphorylation of STAT protein

NF2 LYN KIT

3.64e-0585163GO:0042509
GeneOntologyBiologicalProcesstyrosine phosphorylation of STAT protein

NF2 LYN KIT

4.32e-0590163GO:0007260
GeneOntologyBiologicalProcesstube development

CRISPLD2 KIT COBL ADIPOR2 CFTR STAB2 OTULIN

4.38e-051402167GO:0035295
GeneOntologyBiologicalProcessmast cell activation

LYN KIT CFTR

6.09e-05101163GO:0045576
GeneOntologyBiologicalProcessanatomical structure formation involved in morphogenesis

NF2 COBL ADIPOR2 PRKDC CFTR STAB2 OTULIN

6.28e-051483167GO:0048646
GeneOntologyBiologicalProcessectopic germ cell programmed cell death

KIT PRKDC

1.17e-0421162GO:0035234
GeneOntologyBiologicalProcessregulation of protein phosphorylation

NF2 LYN KIT ADIPOR2 PRKDC DIRAS1

1.35e-041133166GO:0001932
GeneOntologyBiologicalProcessregulation of mast cell activation

LYN CFTR

1.54e-0424162GO:0033003
GeneOntologyBiologicalProcessimmature B cell differentiation

KIT PRKDC

1.67e-0425162GO:0002327
GeneOntologyBiologicalProcesslymphoid progenitor cell differentiation

KIT PRKDC

1.81e-0426162GO:0002320
GeneOntologyBiologicalProcessregulation of phosphorylation

NF2 LYN KIT ADIPOR2 PRKDC DIRAS1

2.08e-041226166GO:0042325
GeneOntologyBiologicalProcessprogrammed cell death involved in cell development

KIT PRKDC

2.76e-0432162GO:0010623
GeneOntologyBiologicalProcesserythrocyte differentiation

LYN KIT PRKDC

3.15e-04176163GO:0030218
GeneOntologyBiologicalProcesspositive regulation of cellular component organization

NF2 LYN KIT ABCA13 COBL VPS13D

3.75e-041366166GO:0051130
GeneOntologyBiologicalProcesserythrocyte homeostasis

LYN KIT PRKDC

3.94e-04190163GO:0034101
GeneOntologyBiologicalProcessregulation of MAP kinase activity

LYN KIT DIRAS1

4.19e-04194163GO:0043405
GeneOntologyBiologicalProcesshematopoietic progenitor cell differentiation

LYN KIT PRKDC

4.38e-04197163GO:0002244
GeneOntologyBiologicalProcesscell surface receptor signaling pathway via JAK-STAT

NF2 LYN KIT

4.45e-04198163GO:0007259
GeneOntologyBiologicalProcessregulation of phosphate metabolic process

NF2 LYN KIT ADIPOR2 PRKDC DIRAS1

4.64e-041421166GO:0019220
GeneOntologyBiologicalProcessregulation of phosphorus metabolic process

NF2 LYN KIT ADIPOR2 PRKDC DIRAS1

4.68e-041423166GO:0051174
GeneOntologyBiologicalProcesslipid transport

LYN ABCA13 VPS13D CFTR

5.15e-04506164GO:0006869
GeneOntologyBiologicalProcesscell surface receptor signaling pathway via STAT

NF2 LYN KIT

5.74e-04216163GO:0097696
GeneOntologyBiologicalProcessregulation of protein modification process

NF2 LYN KIT ADIPOR2 PRKDC DIRAS1

5.95e-041488166GO:0031399
GeneOntologyBiologicalProcessmyeloid cell homeostasis

LYN KIT PRKDC

7.79e-04240163GO:0002262
GeneOntologyBiologicalProcesslipid localization

LYN ABCA13 VPS13D CFTR

7.80e-04565164GO:0010876
GeneOntologyBiologicalProcesscytokine-mediated signaling pathway

LYN KIT ADIPOR2 OTULIN

8.44e-04577164GO:0019221
GeneOntologyBiologicalProcessmulticellular organismal-level homeostasis

LYN KIT ADIPOR2 PRKDC CFTR

8.96e-041043165GO:0048871
GeneOntologyBiologicalProcessregulation of erythrocyte differentiation

LYN PRKDC

9.73e-0460162GO:0045646
GeneOntologyBiologicalProcessregulation of glial cell proliferation

NF2 LYN

1.04e-0362162GO:0060251
GeneOntologyBiologicalProcessFc receptor signaling pathway

LYN KIT

1.04e-0362162GO:0038093
GeneOntologyBiologicalProcessregulation of protein kinase activity

NF2 LYN KIT DIRAS1

1.04e-03611164GO:0045859
GeneOntologyBiologicalProcesspositive regulation of cell development

LYN KIT PRKDC CFTR

1.06e-03614164GO:0010720
GeneOntologyBiologicalProcessimmune response-regulating signaling pathway

LYN KIT PRKDC OTULIN

1.07e-03615164GO:0002764
GeneOntologyBiologicalProcessregulation of cell development

NF2 LYN KIT PRKDC CFTR

1.12e-031095165GO:0060284
GeneOntologyBiologicalProcessregulation of peptidyl-tyrosine phosphorylation

NF2 LYN KIT

1.12e-03272163GO:0050730
GeneOntologyBiologicalProcesspositive regulation of tyrosine phosphorylation of STAT protein

LYN KIT

1.28e-0369162GO:0042531
GeneOntologyBiologicalProcesspositive regulation of cell differentiation

NF2 LYN KIT PRKDC CFTR

1.34e-031141165GO:0045597
GeneOntologyBiologicalProcesspattern recognition receptor signaling pathway

LYN PRKDC OTULIN

1.40e-03294163GO:0002221
GeneOntologyBiologicalProcessregulation of vesicle-mediated transport

NF2 LYN ABCA13 CFTR

1.45e-03667164GO:0060627
GeneOntologyBiologicalProcessmast cell degranulation

LYN KIT

1.47e-0374162GO:0043303
GeneOntologyBiologicalProcessregulation of cell morphogenesis

NF2 KIT PRKDC

1.51e-03302163GO:0022604
GeneOntologyBiologicalProcesssomitogenesis

COBL PRKDC

1.55e-0376162GO:0001756
GeneOntologyBiologicalProcessmast cell mediated immunity

LYN KIT

1.55e-0376162GO:0002448
GeneOntologyBiologicalProcessregulation of kinase activity

NF2 LYN KIT DIRAS1

1.60e-03686164GO:0043549
GeneOntologyBiologicalProcessmast cell activation involved in immune response

LYN KIT

1.64e-0378162GO:0002279
GeneOntologyBiologicalProcesscell morphogenesis

NF2 LYN KIT COBL PRKDC

1.65e-031194165GO:0000902
GeneOntologyBiologicalProcessinnate immune response-activating signaling pathway

LYN PRKDC OTULIN

1.66e-03312163GO:0002758
GeneOntologyBiologicalProcessmyeloid leukocyte activation

LYN KIT CFTR

1.78e-03320163GO:0002274
GeneOntologyBiologicalProcesspeptidyl-tyrosine phosphorylation

NF2 LYN KIT

1.90e-03327163GO:0018108
GeneOntologyBiologicalProcesspeptidyl-tyrosine modification

NF2 LYN KIT

1.93e-03329163GO:0018212
GeneOntologyBiologicalProcesspositive regulation of protein phosphorylation

LYN KIT ADIPOR2 DIRAS1

1.96e-03724164GO:0001934
GeneOntologyBiologicalProcesspositive regulation of immune system process

LYN KIT PRKDC CFTR OTULIN

1.96e-031242165GO:0002684
GeneOntologyBiologicalProcessactivation of innate immune response

LYN PRKDC OTULIN

2.00e-03333163GO:0002218
GeneOntologyBiologicalProcessglial cell proliferation

NF2 LYN

2.03e-0387162GO:0014009
GeneOntologyBiologicalProcessB cell activation

LYN KIT PRKDC

2.14e-03341163GO:0042113
GeneOntologyBiologicalProcessnegative regulation of cell development

NF2 LYN CFTR

2.36e-03353163GO:0010721
GeneOntologyBiologicalProcesssomite development

COBL PRKDC

2.37e-0394162GO:0061053
GeneOntologyBiologicalProcessregulation of protein serine/threonine kinase activity

LYN KIT DIRAS1

2.45e-03358163GO:0071900
GeneOntologyBiologicalProcesspositive regulation of phosphorylation

LYN KIT ADIPOR2 DIRAS1

2.57e-03780164GO:0042327
GeneOntologyBiologicalProcessnegative regulation of protein phosphorylation

NF2 LYN PRKDC

2.80e-03375163GO:0001933
GeneOntologyBiologicalProcesssteroid metabolic process

KIT CFTR UGT2B28

2.82e-03376163GO:0008202
GeneOntologyBiologicalProcessregulation of transferase activity

NF2 LYN KIT DIRAS1

2.94e-03810164GO:0051338
HumanPhenoLeukocytosis

LYN KIT CFTR OTULIN

2.97e-0515974HP:0001974
HumanPhenoElevated circulating C-reactive protein concentration

LYN CFTR OTULIN

1.30e-048173HP:0011227
HumanPhenoAbnormal circulating C-reactive protein concentration

LYN CFTR OTULIN

1.44e-048473HP:0032436
MousePhenoabnormal bile duct epithelium morphology

NF2 CFTR

5.58e-064142MP:0013611
MousePhenosmall cecum

KIT CFTR

9.30e-065142MP:0009477
MousePhenoabnormal small intestinal crypt cell physiology

PRKDC CFTR

5.10e-0511142MP:0010156
MousePhenoincreased mast cell number

LYN KIT

6.11e-0512142MP:0000324
MousePhenoperitoneal inflammation

LYN CFTR

6.11e-0512142MP:0003303
MousePhenospleen hyperplasia

LYN KIT CFTR

7.52e-0585143MP:0000693
MousePhenointestinal obstruction

KIT CFTR

8.42e-0514142MP:0003270
MousePhenoabnormal level of surface class II molecules

LYN PRKDC

1.93e-0421142MP:0005042
MousePhenoabnormal digestive system physiology

PNLIPRP2 LYN KIT PRKDC CFTR

2.06e-04599145MP:0001663
MousePhenospleen hypoplasia

LYN KIT PRKDC

2.54e-04128143MP:0000694
MousePhenoabnormal antigen presentation via MHC class II

LYN PRKDC

2.54e-0424142MP:0005041
MousePhenoabnormal complement pathway

LYN PRKDC

2.99e-0426142MP:0002471
MousePhenoabnormal mast cell number

LYN KIT

3.22e-0427142MP:0020203
MousePhenohyperpigmentation

KIT PRKDC

3.47e-0428142MP:0001188
MousePhenosmall Peyer's patches

LYN PRKDC

3.47e-0428142MP:0008135
MousePhenoincreased urine protein level

LYN KIT PRKDC

3.96e-04149143MP:0002962
MousePhenogastrointestinal ulcer

KIT CFTR

4.26e-0431142MP:0003300
MousePhenodecreased litter size

KIT COBL TEKT4 CFTR

4.33e-04380144MP:0001935
MousePhenodecreased epididymis weight

KIT ADIPOR2

4.83e-0433142MP:0004929
MousePhenoabnormal ileum morphology

KIT CFTR

4.83e-0433142MP:0002581
MousePhenodecreased spleen white pulp amount

LYN PRKDC

5.13e-0434142MP:0008479
MousePhenomyeloid hyperplasia

LYN PRKDC

5.13e-0434142MP:0010373
MousePhenoabnormal litter size

KIT COBL TEKT4 CFTR

5.21e-04399144MP:0001933
MousePhenoabnormal Peyer's patch size

LYN PRKDC

5.75e-0436142MP:0008134
MousePhenoabnormal urine protein level

LYN KIT PRKDC

5.83e-04170143MP:0006315
MousePhenoabnormal tumor pathology

NF2 KIT STAB2

6.45e-04176143MP:0010639
MousePhenoabnormal nephron morphology

NF2 LYN KIT PRKDC

6.68e-04426144MP:0003881
MousePhenoabnormal hepatobiliary system physiology

LYN PRKDC CFTR STAB2

7.10e-04433144MP:0002139
MousePhenoimpaired humoral immune response

LYN PRKDC

7.11e-0440142MP:0020154
MousePhenoincreased plasma cell number

LYN PRKDC

7.11e-0440142MP:0008097
MousePhenoabnormal epididymis weight

KIT ADIPOR2

7.84e-0442142MP:0004927
MousePhenoabnormal mast cell morphology

LYN KIT

7.84e-0442142MP:0000359
MousePhenoabnormal granulocyte number

LYN KIT ADIPOR2 PRKDC CFTR

8.09e-04805145MP:0020201
MousePhenoincreased erythroid progenitor cell number

LYN KIT

9.00e-0445142MP:0003135
MousePhenoarrested B cell differentiation

KIT PRKDC

9.40e-0446142MP:0001802
MousePhenoabnormal granulocyte morphology

LYN KIT ADIPOR2 PRKDC CFTR

9.56e-04835145MP:0002441
MousePhenoabnormal gastrointestinal motility

KIT CFTR

1.20e-0352142MP:0011082
MousePhenoabnormal neutrophil cell number

LYN ADIPOR2 PRKDC CFTR

1.21e-03499144MP:0012440
MousePhenoabnormal neutrophil morphology

LYN ADIPOR2 PRKDC CFTR

1.32e-03511144MP:0005065
MousePhenoabnormal large intestine crypts of Lieberkuhn morphology

PRKDC CFTR

1.34e-0355142MP:0004842
MousePhenodecreased circulating HDL cholesterol level

LYN KIT ADIPOR2

1.40e-03230143MP:0000186
MousePhenoincreased B-1 B cell number

LYN PRKDC

1.54e-0359142MP:0004977
MousePhenoabnormal plasma cell number

LYN PRKDC

1.54e-0359142MP:0008096
MousePhenoincreased dendritic cell number

LYN PRKDC

1.59e-0360142MP:0008126
MousePhenoabnormal bile duct morphology

NF2 CFTR

1.81e-0364142MP:0002928
MousePhenoabnormal response to transplant

KIT PRKDC

1.81e-0364142MP:0005671
MousePhenodecreased granulocyte number

KIT PRKDC CFTR

1.86e-03254143MP:0000334
MousePhenodistended abdomen

KIT CFTR

1.87e-0365142MP:0001270
MousePhenoglomerulosclerosis

LYN PRKDC

2.04e-0368142MP:0005264
MousePhenoabnormal renal glomerulus morphology

LYN KIT PRKDC

2.08e-03264143MP:0005325
MousePhenosmall epididymis

KIT ADIPOR2

2.16e-0370142MP:0004930
MousePhenoincreased B cell number

LYN KIT PRKDC

2.24e-03271143MP:0005014
MousePhenoabnormal antigen presentation

LYN PRKDC

2.29e-0372142MP:0001835
MousePhenodecreased circulating triglyceride level

LYN CRISPLD2 ADIPOR2

2.33e-03275143MP:0002644
MousePhenoincreased granulocyte number

LYN KIT ADIPOR2 PRKDC

2.34e-03597144MP:0000322
MousePhenoabnormal large intestine morphology

KIT PRKDC CFTR

2.36e-03276143MP:0000489
MousePhenoabnormal sexual maturation

KIT CFTR

2.41e-0374142MP:0001937
MousePhenoabnormal proerythroblast morphology

LYN KIT

2.41e-0374142MP:0002416
MousePhenoabnormal plasma cell morphology

LYN PRKDC

2.48e-0375142MP:0002439
MousePhenoabnormal intestinal epithelium physiology

PRKDC CFTR

2.54e-0376142MP:0014201
MousePhenoabnormal B cell differentiation

LYN KIT PRKDC

2.64e-03287143MP:0002144
MousePhenoabnormal renal corpuscle morphology

LYN KIT PRKDC

2.79e-03293143MP:0002827
MousePhenodecreased B-1 B cell number

LYN PRKDC

2.88e-0381142MP:0004978
MousePhenoabnormal class switch recombination

LYN PRKDC

2.88e-0381142MP:0004816
MousePhenoabnormal hematopoietic precursor cell morphology

LYN KIT PRKDC

2.96e-03299143MP:0013707
DomainABC_TRANSPORTER_2

ABCA13 CFTR

8.58e-0448172PS50893
DomainABC_tran

ABCA13 CFTR

8.58e-0448172PF00005
DomainABC_TRANSPORTER_1

ABCA13 CFTR

8.94e-0449172PS00211
DomainABC_transporter-like

ABCA13 CFTR

9.31e-0450172IPR003439
DomainTyrKc

LYN KIT

2.85e-0388172SM00219
DomainTyr_kinase_cat_dom

LYN KIT

2.85e-0388172IPR020635
DomainPROTEIN_KINASE_TYR

LYN KIT

3.45e-0397172PS00109
DomainTyr_kinase_AS

LYN KIT

3.45e-0397172IPR008266
DomainPkinase_Tyr

LYN KIT

6.02e-03129172PF07714
DomainSer-Thr/Tyr_kinase_cat_dom

LYN KIT

6.85e-03138172IPR001245
DomainAAA+_ATPase

ABCA13 CFTR

7.44e-03144172IPR003593
DomainAAA

ABCA13 CFTR

7.44e-03144172SM00382
DomainKinase-like_dom

LYN KIT PRKDC

1.22e-02542173IPR011009
PathwayREACTOME_REGULATION_OF_KIT_SIGNALING

LYN KIT

5.15e-0513122MM14565
PathwayREACTOME_REGULATION_OF_KIT_SIGNALING

LYN KIT

7.92e-0516122M537
PathwayREACTOME_SIGNALING_BY_KIT_IN_DISEASE

LYN KIT

1.25e-0420122M39002
PathwayREACTOME_SIGNALING_BY_SCF_KIT

LYN KIT

4.35e-0437122MM14564
PathwayREACTOME_SIGNALING_BY_SCF_KIT

LYN KIT

5.88e-0443122M508
PathwayKEGG_ABC_TRANSPORTERS

ABCA13 CFTR

6.16e-0444122M11911
PathwayPID_KIT_PATHWAY

LYN KIT

8.60e-0452122M231
Pubmed

The Src and c-Kit kinase inhibitor dasatinib enhances p53-mediated targeting of human acute myeloid leukemia stem cells by chemotherapeutic agents.

LYN KIT PRKDC

5.42e-09817323896410
Pubmed

A KIT juxtamembrane PY567 -directed pathway provides nonredundant signals for erythroid progenitor cell development and stress erythropoiesis.

LYN KIT

2.25e-07217219100679
Pubmed

Lyn associates with the juxtamembrane region of c-Kit and is activated by stem cell factor in hematopoietic cell lines and normal progenitor cells.

LYN KIT

2.25e-0721729341198
Pubmed

Regulation of DNA-dependent protein kinase by the Lyn tyrosine kinase.

LYN PRKDC

2.25e-0721729748231
Pubmed

Mast cells decrease efficacy of anti-angiogenic therapy by secreting matrix-degrading granzyme B.

KIT PRKDC

6.74e-07317228814715
Pubmed

Kit regulates HSC engraftment across the human-mouse species barrier.

KIT PRKDC

6.74e-07317225017720
Pubmed

A simultaneous knockout knockin genome editing strategy in HSPCs potently inhibits CCR5- and CXCR4-tropic HIV-1 infection.

KIT PRKDC

6.74e-07317238579682
Pubmed

Basophils and the T helper 2 environment can promote the development of lupus nephritis.

LYN KIT

6.74e-07317220512127
Pubmed

Nonirradiated NOD,B6.SCID Il2rγ-/- Kit(W41/W41) (NBSGW) mice support multilineage engraftment of human hematopoietic cells.

KIT PRKDC

6.74e-07317225601207
Pubmed

Phosphorylated T567 ezrin is associated with merlin expression in KIT-mutant gastrointestinal stromal tumors.

NF2 KIT

6.74e-07317221971708
Pubmed

Small-Molecule PAPD5 Inhibitors Restore Telomerase Activity in Patient Stem Cells.

KIT PRKDC

6.74e-07317232320679
Pubmed

Human KIT+ myeloid cells facilitate visceral metastasis by melanoma.

KIT PRKDC

6.74e-07317233857287
Pubmed

Thrombopoietin-increased DNA-PK-dependent DNA repair limits hematopoietic stem and progenitor cell mutagenesis in response to DNA damage.

KIT PRKDC

6.74e-07317223246483
Pubmed

A mast cell-ILC2-Th9 pathway promotes lung inflammation in cystic fibrosis.

KIT CFTR

6.74e-07317228090087
Pubmed

Coexpression of CD71 and CD117 Identifies an Early Unipotent Neutrophil Progenitor Population in Human Bone Marrow.

KIT PRKDC

1.35e-06417232814027
Pubmed

Human T cell generation is restored in CD3δ severe combined immunodeficiency through adenine base editing.

KIT PRKDC

1.35e-06417236944331
Pubmed

Btk plays a crucial role in the amplification of Fc epsilonRI-mediated mast cell activation by kit.

LYN KIT

1.35e-06417216176929
Pubmed

Kcnn4 is a modifier gene of intestinal cystic fibrosis preventing lethality in the Cftr-F508del mouse.

KIT CFTR

1.35e-06417229915289
Pubmed

IL-9 and Mast Cells Are Key Players of Candida albicans Commensalism and Pathogenesis in the Gut.

KIT CFTR

1.35e-06417229742432
Pubmed

Mobilization-based chemotherapy-free engraftment of gene-edited human hematopoietic stem cells.

KIT PRKDC

1.35e-06417235617958
Pubmed

BRD9 regulates normal human hematopoietic stem cell function and lineage differentiation.

KIT PRKDC

1.35e-06417238816579
Pubmed

Activation of the receptor tyrosine kinase RET improves long-term hematopoietic stem cell outgrowth and potency.

KIT PRKDC

1.35e-06417232589703
Pubmed

Phosphatidylinositol 3-kinase and Src family kinases are required for phosphorylation and membrane recruitment of Dok-1 in c-Kit signaling.

LYN KIT

2.25e-06517211825908
Pubmed

Lyn kinase controls basophil GATA-3 transcription factor expression and induction of Th2 cell differentiation.

LYN KIT

2.25e-06517219362019
Pubmed

Stimulation of nAchRα7 Receptor Inhibits TNF Synthesis and Secretion in Response to LPS Treatment of Mast Cells by Targeting ERK1/2 and TACE Activation.

LYN KIT

2.25e-06517228822039
Pubmed

Kit signaling through PI 3-kinase and Src kinase pathways: an essential role for Rac1 and JNK activation in mast cell proliferation.

LYN KIT

3.37e-0661729799234
Pubmed

Steel factor stimulates the tyrosine phosphorylation of the proto-oncogene product, p95vav, in human hemopoietic cells.

LYN KIT

3.37e-0661721381360
Pubmed

Genetically determined murine models of immunodeficiency.

KIT PRKDC

6.29e-0681723297105
Pubmed

Gab2 is involved in differential phosphoinositide 3-kinase signaling by two splice forms of c-Kit.

LYN KIT

8.08e-06917218697750
Pubmed

Isolation and chromosomal location of Nsk1, a novel murine putative receptor tyrosine kinase.

LYN KIT

1.01e-05101728535092
Pubmed

Molecular cloning of the mouse APS as a member of the Lnk family adaptor proteins.

LYN KIT

1.48e-051217210872802
Pubmed

Massively parallel sequencing of the mouse exome to accurately identify rare, induced mutations: an immediate source for thousands of new mouse models.

LYN PRKDC

1.75e-051317222724066
Pubmed

Stem cell factor induces phosphatidylinositol 3'-kinase-dependent Lyn/Tec/Dok-1 complex formation in hematopoietic cells.

LYN KIT

2.69e-051617211071635
Pubmed

Comparative analysis of 1196 orthologous mouse and human full-length mRNA and protein sequences.

NF2 CFTR

6.70e-05251728889551
Pubmed

GATA4-dependent organ-specific endothelial differentiation controls liver development and embryonic hematopoiesis.

KIT STAB2

8.44e-052817228218627
Pubmed

Murine txk: a protein tyrosine kinase gene regulated by T cell activation.

LYN KIT

1.11e-04321727542761
Pubmed

Interactomes of Glycogen Synthase Kinase-3 Isoforms.

COBL VPS13D OTULIN

1.37e-0420917336779422
Pubmed

The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.

NF2 LYN COBL CFTR

1.42e-0456917430639242
Pubmed

Genome-wide data reveal novel genes for methotrexate response in a large cohort of juvenile idiopathic arthritis cases.

CFTR STAB2

1.65e-043917224709693
Pubmed

Activated Braf induces esophageal dilation and gastric epithelial hyperplasia in mice.

KIT COBL

2.20e-044517228973166
Pubmed

A Hypoxia-Induced SCFFBXL1 E3 Ligase Ubiquitinates and Degrades the MEN1 Tumor Suppressor to Promote Colorectal Cancer Tumorigenesis.

NF2 PRKDC

3.29e-045517234237211
Pubmed

Genetic mutations associated with cigarette smoking in pancreatic cancer.

NF2 KIT

4.32e-046317219351817
InteractionLPCAT1 interactions

NF2 ADIPOR2 CFTR OTULIN

2.75e-06129164int:LPCAT1
CytobandEnsembl 112 genes in cytogenetic band chr7p12

ABCA13 COBL

2.49e-0463172chr7p12
ToppCellSmart-seq2-lymph_node_(Smart-seq2)-myeloid-myeloid_granulocytic|lymph_node_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

CRISPLD2 KIT UGT2B28

2.48e-0515217332634195048858ae84605c61e43c542d90f7cab5
ToppCellSmart-seq2-lymph_node_(Smart-seq2)-myeloid-myeloid_granulocytic-mast_cell|lymph_node_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

CRISPLD2 KIT UGT2B28

2.48e-051521730eb185b2404f015efff1bd140e0c502d714720fb
ToppCelldroplet-Spleen-nan-18m-Myeloid-granulocyte|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CRISPLD2 ABCA13 CFTR

3.06e-05163173bc37c5d9f48b16096d5313657563f3ec84028c8c
ToppCellNS-control-d_0-4-Epithelial-Ionocyte|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

KIT CFTR STAB2

3.23e-051661736d9fb239f69ba519844f593c00d515e1aac4ff50
ToppCellNS-critical-d_16-33-Epithelial-Ionocyte|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

KIT CFTR STAB2

3.35e-051681736a233045638cb83dab64789b996b7598c325001e
ToppCellBronchial_Biopsy-Epithelial-Ionocytes|Bronchial_Biopsy / Tissue, Lineage and Cell class of Lung Cells from 10X

KIT CFTR STAB2

3.71e-051741737e7b13de916cd4fa0fa6fb06e6b4942877afa9fb
ToppCellBronchial_Biopsy-Epithelial-Ionocytes|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X

KIT CFTR STAB2

3.78e-0517517313b8f7dc38c90b74d4a20a84a8705d8e2ec244f6
ToppCell3'_v3-blood-Mast-Mast_cells|blood / Manually curated celltypes from each tissue

CRISPLD2 KIT DIRAS1

3.84e-05176173b9da3deaf62622d47eb30b6be7548253eee95597
ToppCell3'-Airway_Nasal-Epithelial-Neuro-endocrine/ionocytic-ionocyte-Ionocyte|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KIT CFTR STAB2

3.91e-051771736d89042bda8e244babb68929e84b25edcb545a77
ToppCell3'-Airway_Nasal-Epithelial-Neuro-endocrine/ionocytic-ionocyte-Ionocyte-Ionocyte_L.0.7.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KIT CFTR STAB2

3.91e-05177173daaccf1249dcf816df4caca695a944f53078291a
ToppCell3'-Airway_Nasal-Epithelial-Neuro-endocrine/ionocytic|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KIT CFTR STAB2

3.91e-05177173c5a16f984c836dbf7d0faf061677844167ab612a
ToppCell3'-Airway_Nasal-Epithelial-Neuro-endocrine/ionocytic-ionocyte|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KIT CFTR STAB2

3.91e-05177173338bdda26796bf4e16072878c070212d1006cf57
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

KIT ADIPOR2 CFTR

4.04e-05179173e6ae070b4c52ba08167c7d64ea4cfbac0454c1bf
ToppCellE16.5-samps-Endothelial-Immature_fetal_endothelial-Proliferative_Endothelial|E16.5-samps / Age Group, Lineage, Cell class and subclass

LYN KIT STAB2

4.04e-05179173d24513a404c9b1d37dd47aa1cdb5713b64b88f89
ToppCellNS-moderate-d_16-33-Epithelial-Ionocyte|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

KIT CFTR STAB2

4.11e-051801738af8b4af2dc72223ac71fc027e0d4280c5dd81f8
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

KIT ADIPOR2 CFTR

4.18e-0518117330729f0364f719c044712a51453e22dc2c1a232b
ToppCellNS-critical-d_07-13-Epithelial-Ionocyte|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

KIT CFTR STAB2

4.32e-05183173ba43bca2b45be1008eebd3f033cecb061fb3a966
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABCA13 CFTR STAB2

4.39e-05184173ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABCA13 CFTR STAB2

4.39e-051841732cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABCA13 CFTR STAB2

4.39e-051841732b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellcritical-Epithelial-Ionocyte|critical / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

KIT CFTR STAB2

4.39e-0518417358d36577eff814d46d72f031f3533d71549e3d6e
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Degenerative_Cortical_Intercalated_Cell_Type_A|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

KIT ADIPOR2 CFTR

4.46e-051851739438097e94219c1db922b8507e3a29106d32a923
ToppCellmoderate-Epithelial-Ionocyte|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

KIT CFTR STAB2

4.60e-051871733e3fe2d5712a0ac477cddefe56705d4b8d8f7eac
ToppCellmoderate-Epithelial-Ionocyte|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

KIT CFTR STAB2

4.75e-051891736011b747e27d61d222380a7bffdd921a68e9b657
ToppCelldroplet-Lung-nan-18m-Epithelial|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COBL TEKT4 CFTR

4.83e-05190173b057bea6e55cef872290893b6e439bbcdcee2f2e
ToppCelldroplet-Lung-immune-endo-depleted-3m-Epithelial|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COBL TEKT4 CFTR

4.83e-05190173edc0a0eb17abbecb0f06d302be3d4f8c1dd4f333
ToppCellCOPD-Myeloid-Mast|Myeloid / Disease state, Lineage and Cell class

KIT COBL CFTR

4.83e-05190173379dbac19110b76079a7a53209569e060a852acb
ToppCellfacs-Mammary_Gland-Mammary_Gland-18m-Epithelial-luminal_epithelial_cell_of_mammary_gland|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LYN KIT COBL

5.06e-051931731526f51b589a7dc7a28f35f0e788dc38d338d2bc
ToppCellTracheal-10x5prime-Epithelial-Epi_airway_neuro-secretory|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

KIT CFTR STAB2

5.29e-05196173a4cc02ea41479d24044bd2ca6441f85d683c0ca9
ToppCellTracheal-NucSeq-Epithelial-Epi_airway_secretory|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

LYN ABCA13 CFTR

5.29e-05196173b07db4a53ab9be9aad6fae5e45f9547db829d096
ToppCellTracheal-10x5prime-Epithelial-Epi_airway_neuro-secretory-Ionocyte_n_Brush|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

KIT CFTR STAB2

5.29e-0519617350aaca81b593ff71790bb75403b2e4c3ab03a6d2
ToppCellTracheal-NucSeq-Epithelial-Epi_airway_secretory-Secretory_Goblet|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

LYN ABCA13 CFTR

5.29e-05196173c366f980cc04abfe1c0c14746c11810c812a42c0
ToppCellBronchus_Control_(B.)-Epithelial-TX-AT1|Bronchus_Control_(B.) / Sample group, Lineage and Cell type

KIT CFTR STAB2

5.37e-05197173f7ef62d78336812573148f8bfce401877ec4e29c
ToppCellPosterior_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Cplx3-Inhibitory_Neuron.Gad1Gad2.Cplx3-Egln3_(Cortical_subplate_interneuron)|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

ABCA13 STAB2

1.83e-045317252a1f2a041e3ba2b11ed753f2f57b78e68b5cc0c
ToppCellPosterior_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Cplx3-Inhibitory_Neuron.Gad1Gad2.Cplx3-Egln3_(Cortical_subplate_interneuron)-|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

ABCA13 STAB2

1.83e-04531725fa009c9f30c77de6cece40a47da46241f1de54c
ToppCell368C-Lymphocytic-NK_cells-NK_cell_E|NK_cells / Donor, Lineage, Cell class and subclass (all cells)

KIT ADIPOR2

5.05e-0488172142d2e00ef19c0ad011a21945bf1111271056eae
ToppCellParenchymal-10x5prime-Epithelial-Epi_submucosal-gland|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

ABCA13 CFTR

7.58e-0410817275d635fc5bb004418db2e1328c24d96b718f10b1
ToppCellParenchymal-10x5prime-Epithelial-Epi_submucosal-gland-SMG_Duct|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

ABCA13 CFTR

7.58e-041081729c7f3e25facfb54ef0be45044999bc36438bbea0
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Outer_Medullary_Collecting_Duct_Intercalated_Cell_Type_A|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

KIT CFTR

9.97e-041241721fec6663cea40017438ead397b3bf8b3cdb67e58
ToppCellEntopeduncular-Macroglia-ASTROCYTE|Entopeduncular / BrainAtlas - Mouse McCarroll V32

TEKT4 STAB2

1.08e-03129172c37bdd6c0b2944fbfa064922954ea0e263160e2a
ToppCellEntopeduncular-Macroglia-ASTROCYTE-Gja1|Entopeduncular / BrainAtlas - Mouse McCarroll V32

TEKT4 STAB2

1.08e-031291728648ae59f7aca0f5b4983bdb4a65b03b2ca761e1
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Col15a1_Pde1a|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

CRISPLD2 KIT

1.10e-0313017256b9c3325e011f1dbaf9efc71bd6e1af4f96fda6
ToppCellLPS-IL1RA+antiTNF-Hematopoietic_Mast-Mast_cells-Mast-cells|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

KIT DIRAS1

1.15e-0313317281189e8516a431d5890a0909f9fc7c82ec3442bc
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Col15a1_Pde1a|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

CRISPLD2 KIT

1.16e-03134172d63fff23040eada31bc35ba1e05b7c6a663e0037
ToppCell(09)_Ionocytes|World / shred by cell type and Timepoint

KIT CFTR

1.18e-03135172237b9b646513ca6e4b754c0da95d24015b3661f7
ToppCell10x_3'_v3-blood_(10x_3'_v3)-hematologic-hematopoietic_progenitor-common_myeloid_progenitor|blood_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

KIT DIRAS1

1.21e-031371726d90da42dcc06aa895f920218055068f3c76d57d
ToppCellTCGA-Kidney-Primary_Tumor-Renal_Cell_Carcinoma-Kidney_Chromophobe-9|TCGA-Kidney / Sample_Type by Project: Shred V9

KIT CFTR

1.25e-03139172a93b861906d7f01ff715084f99152ec83529f8b3
ToppCellTCGA-Kidney-Primary_Tumor-Renal_Cell_Carcinoma-Kidney_Chromophobe|TCGA-Kidney / Sample_Type by Project: Shred V9

KIT CFTR

1.27e-03140172bc5bed94c33129391ca35791febb55cc4cdff989
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Connecting_Tubule_Intercalated_Cell_Type_A|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

KIT CFTR

1.36e-031451729964d6d3769be2f35d86268fe044cecd1d5a1616
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Crispld2_Htr2c|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

CRISPLD2 KIT

1.38e-0314617247368f981180ca6a8c81a50f7f9430f12456f609
ToppCellP15-Epithelial-epithelial_progenitor_cell-epithelial_progenitor_cell|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

COBL CFTR

1.40e-03147172aba44c7057096483c4293a7ebcf8ccc8baed0231
ToppCell356C-Myeloid-Mast_cell|356C / Donor, Lineage, Cell class and subclass (all cells)

KIT COBL

1.42e-031481721668d8a9e680da335362744f36b05446c499347e
ToppCell356C-Myeloid-Mast_cell-|356C / Donor, Lineage, Cell class and subclass (all cells)

KIT COBL

1.42e-0314817218511ba10765eda937c5a710626361f7e6b9b321
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

KIT CFTR

1.43e-03149172cc911b454fe4e4b489885b9920baa7eb01a027ba
ToppCellfacs-Liver-Liver_non-hepato/SCs_st-18m-Myeloid-neutrophil|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CRISPLD2 ABCA13

1.45e-031501726e806a028c0519489151c181d9907e05289e27e0
ToppCell368C-Myeloid-Mast_cell|368C / Donor, Lineage, Cell class and subclass (all cells)

KIT COBL

1.49e-03152172faf30245a1690aaa27c7be0832797c340e4af4d7
ToppCell368C-Myeloid-Mast_cell-|368C / Donor, Lineage, Cell class and subclass (all cells)

KIT COBL

1.49e-03152172519c9ed05fdaf420e42147ffae1dc05a7f86fdd4
ToppCellTCGA-Thymus-Primary_Tumor-Thymoma-Type_C-8|TCGA-Thymus / Sample_Type by Project: Shred V9

KIT UGT2B28

1.55e-0315517200eef9f93a753a1fe1ab5fd8dae026e7be556cde
ToppCelldroplet-Kidney-KIDNEY-30m-Myeloid-nan|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PNLIPRP2 LYN

1.57e-031561726e60e860603a7e8194f437a574ff8e887f6083b8
ToppCellfacs-Spleen-nan-24m-Myeloid|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CRISPLD2 ABCA13

1.57e-03156172034d4359359a44c205c6931f38a375271ac2752b
ToppCellCOVID-19-Mast_cells|COVID-19 / group, cell type (main and fine annotations)

KIT COBL

1.57e-03156172159504d43421ee83b9ab484816333ae549c9c2fd
ToppCellfacs-Spleen-nan-24m-Myeloid-nan|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CRISPLD2 ABCA13

1.57e-031561722a4dac4100c0339aad4905b8eaca6e8fe806718b
ToppCellfacs-Spleen-nan-24m-Myeloid-granulocyte|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CRISPLD2 ABCA13

1.57e-0315617221267718d3a3dc19988663b6846aed8bb3eae836
ToppCelldroplet-Limb_Muscle-MUSCLE-30m-Myeloid-macrophage|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LYN ABCA13

1.57e-03156172c841faa1695ff577b0774f531adf1343d05dce9e
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Crispld2_Kcne4|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

CRISPLD2 KIT

1.57e-03156172896e2d958be0a5c62fb6eebad2dfb7e1ce69f3ad
ToppCellCOVID-19-Mast_cells-Mast_cells|COVID-19 / group, cell type (main and fine annotations)

KIT COBL

1.57e-03156172bc10b94673184ef384c6665b16a1209a8975a4f1
ToppCelldroplet-Limb_Muscle-MUSCLE-30m-Myeloid|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LYN ABCA13

1.57e-0315617221baf8c6e62bb7fd1530c2c100f73c0cecee092e
ToppCellfacs-Trachea-24m-Hematologic-myeloid-granulocyte-granulocyte_l26|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

KIT COBL

1.57e-03156172da5cfa8fa9595613f04ce9511f8b42bad34d995a
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

KIT CFTR

1.59e-03157172c17c5c01fcb65c453690c265ec4f300ecdfefd34
ToppCellfacs-Heart-LV-24m-Lymphocytic-T_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PNLIPRP2 CFTR

1.61e-0315817212a82230c01de552f12977634c304626e1cd6903
ToppCellLPS_only-Myeloid-Monocytes,_Macrophages-T-cells|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

KIT DIRAS1

1.61e-0315817291d8c93af328c3bbebe1d8f019b94849ebc548c0
ToppCellfacs-Heart-LV-24m-Lymphocytic-T_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PNLIPRP2 CFTR

1.61e-03158172bd432ecd2524656804e7c2775250e27db7906b70
ToppCellIPF-Epithelial-Ionocyte|Epithelial / Disease state, Lineage and Cell class

KIT CFTR

1.61e-0315817267adf625a959444762d32268b3b7441f6f8b3b8c
ToppCell10x_3'_v3-thymus_(10x_3'_v3)-myeloid-myeloid_granulocytic-mast_cell|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

KIT COBL

1.63e-03159172ecd1daa33549541aee3bf4e139ab6732efc8e74c
ToppCellFrontal_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

KIT CFTR

1.63e-031591727f29f9dcf25ffa1822b137c571e9ac16defc6292
ToppCell10x_3'_v3-thymus_(10x_3'_v3)-myeloid-myeloid_granulocytic|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

KIT COBL

1.63e-031591727b6370c9567da7d40541c6e243efa704ed7e90ae
ToppCellcellseq2-Epithelial-Epithelial_Neuro-Secretory-Ionocyte|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

KIT CFTR

1.65e-031601729049707a4487f2337a17976ceb5fbd8815ab9e1d
ToppCellPND10-Immune-Immune_Myeloid-Granulocytic-Mast|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

KIT COBL

1.65e-031601726393e3d5c5c8176c93aecd89b313bd054a00d474
ToppCellcellseq2-Epithelial-Epithelial_Neuro-Secretory-Ionocyte-Ionocyte|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

KIT CFTR

1.65e-03160172f2cfec54cf48a655f473b830be7d141c54b521ff
ToppCellPND10-Immune-Immune_Myeloid-Granulocytic-Mast-Mast_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

KIT COBL

1.65e-031601722065938e944eb99478fd8132c2c03adeaee6d447
ToppCellNS-critical-LOC-Myeloid-Basophil|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

KIT DIRAS1

1.65e-031601728a4746463ca1976f7d6de803496c851249ced797
ToppCellIPF-Epithelial-Ionocyte|IPF / Disease state, Lineage and Cell class

KIT CFTR

1.65e-03160172d65d19f4fae60836bfd4303a1bb7de34e9d83e35
ToppCellcellseq2-Epithelial-Epithelial_Neuro-Secretory|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

KIT CFTR

1.65e-031601720eb50b3c494e1b65d40104b3b5411b57bb72b959
ToppCellIPF-Epithelial-Ionocyte|World / Disease state, Lineage and Cell class

KIT CFTR

1.67e-03161172f1cd5c938cdc08ad8995371b72493850a6cf277a
ToppCellMild-MAIT|Mild / Disease group and Cell class

LYN KIT

1.67e-031611720c1a04485708d5302600cdc2d7dac1cb76b4033a
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Crispld2_Kcne4|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

CRISPLD2 KIT

1.67e-03161172be77e99faf653480c166305df3a4e93db76f0dcb
ToppCell3'-Distal_airway-Epithelial-Neuro-endocrine/ionocytic-ionocyte-Ionocyte|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KIT CFTR

1.69e-031621729522af31f6b2f3cb81b6b84bd08353eea504d1d6
ToppCell3'-Distal_airway-Epithelial-Neuro-endocrine/ionocytic-ionocyte|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KIT CFTR

1.69e-031621729a18286e361e1dd18e6f943ce27db58b199fb6e4
ToppCell3'-Distal_airway-Epithelial-Neuro-endocrine/ionocytic|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KIT CFTR

1.69e-0316217240265af9b36fd144a8577b8dacccd4fc0888a593
ToppCellMild_COVID-19-Myeloid-MoAM2|Mild_COVID-19 / Disease group,lineage and cell class （2021.01.30）

LYN CRISPLD2

1.69e-03162172e5fc80ab19d513af6a7e677a5e67bfebca2e963b
ToppCell3'-Distal_airway-Epithelial-Neuro-endocrine/ionocytic-ionocyte-Ionocyte-Ionocyte_L.0.7.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KIT CFTR

1.69e-031621723395e4dffdb9304d157c325e1fc0f12b433c7bd3
ToppCellE18.5-samps-Endothelial-Mature_fetal_endothelial-endothelial_cells_B|E18.5-samps / Age Group, Lineage, Cell class and subclass

KIT STAB2

1.71e-03163172d6f9b7280c44d120df5a72dfc2ebb26ffbb5752b
ToppCellnormal_Pleural_Fluid-Myeloid_cells-Undetermined|Myeloid_cells / Location, Cell class and cell subclass

KIT COBL

1.71e-03163172be774c0ba38fa89a9c0076524cf05d593c6c6826
ToppCellTCGA-Thymus-Primary_Tumor-Thymoma-Type_C|TCGA-Thymus / Sample_Type by Project: Shred V9

KIT UGT2B28

1.71e-031631722dac87d15051151ccf193760ddd8b82534c3f922
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Degenerative_Cortical_Intercalated_Cell_Type_A|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

KIT TEKT4

1.73e-0316417283141be8dfed85511ea6afda7c76ff4b6b5ef021
ToppCell356C-Myeloid-Mast_cell|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

KIT COBL

1.73e-03164172b3192c443f4848e6a8afdb89c155f9ec42a154b0
ToppCellNS-moderate-d_16-33-Myeloid-Mast_cell|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

KIT DIRAS1

1.73e-0316417235c673380f75cb4bfe080089bc723c4373bcc7a5
ToppCellMild-MAIT|World / Disease group and Cell class

LYN KIT

1.73e-0316417221dc02997dfae73cf70ce291661928526605dba1
ToppCell356C-Myeloid-Mast_cell-|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

KIT COBL

1.73e-03164172f7288ec4daf494dae770ea6c58bead27660ccae1
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Connecting_Tubule_Intercalated_Cell_Type_A|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

KIT CFTR

1.75e-031651729bd332e5ede759a00a47728ea5558c215efdd77a
ComputationalNeighborhood of SPINK1

PNLIPRP2 CFTR

3.95e-0427122GNF2_SPINK1
DrugMegestrol acetate [595-33-5]; Up 200; 10.4uM; MCF7; HT_HG-U133A

NF2 KIT VPS13D CFTR

1.16e-051961746468_UP
DrugEsculetin [305-01-1]; Up 200; 22.4uM; MCF7; HT_HG-U133A

NF2 COBL VPS13D STAB2

1.18e-051971747459_UP
DrugTrapidil [15421-84-8]; Up 200; 19.4uM; MCF7; HT_HG-U133A

NF2 CRISPLD2 COBL VPS13D

1.21e-051981747475_UP
Drug(S)-(-)-Atenolol [93379-54-5]; Up 200; 15uM; MCF7; HT_HG-U133A

NF2 KIT VPS13D STAB2

1.23e-051991746444_UP
Drugquinazoline

KIT PRKDC CFTR

1.92e-0571173CID000009210
Drugheptamolybdate

NF2 KIT CFTR

7.49e-05112173CID005288823
DrugAdenosine-5'-Diphosphate

KIT CFTR

3.26e-0436172DB03431
DrugTriflupromazine hydrochloride [1098-60-8]; Up 200; 10.2uM; MCF7; HT_HG-U133A

NF2 CRISPLD2 COBL

3.46e-041881737466_UP
DrugTerfenadine [50679-08-8]; Down 200; 8.4uM; MCF7; HT_HG-U133A

NF2 VPS13D STAB2

3.62e-041911732227_DN
DrugEstriol [50-27-1]; Down 200; 13.8uM; MCF7; HT_HG-U133A

NF2 LYN COBL

3.62e-041911737220_DN
DrugDicumarol [66-76-2]; Up 200; 11.8uM; HL60; HT_HG-U133A

NF2 CFTR STAB2

3.68e-041921732561_UP
DrugCefazolin sodium salt [27164-46-1]; Up 200; 8.4uM; PC3; HT_HG-U133A

NF2 CFTR STAB2

3.74e-041931737385_UP
DrugIohexol [66108-95-0]; Up 200; 4.8uM; PC3; HT_HG-U133A

NF2 KIT COBL

3.79e-041941734643_UP
DrugFluorometholone [426-13-1]; Up 200; 10.6uM; MCF7; HT_HG-U133A

NF2 LYN VPS13D

3.85e-041951736247_UP
DrugLY 294002; Down 200; 10uM; PC3; HT_HG-U133A

NF2 LYN COBL

3.85e-041951731239_DN
DrugBacitracin [1405-87-4]; Up 200; 2.8uM; MCF7; HT_HG-U133A

NF2 CRISPLD2 STAB2

3.85e-041951737448_UP
DrugFurazolidone [67-45-8]; Down 200; 17.8uM; MCF7; HT_HG-U133A

NF2 LYN VPS13D

3.85e-041951733358_DN
DrugCrotamiton [483-63-6]; Down 200; 19.6uM; HL60; HT_HG-U133A

NF2 VPS13D STAB2

3.85e-041951733050_DN
DrugBambuterol hydrochloride [81732-46-9]; Up 200; 10uM; MCF7; HT_HG-U133A

NF2 KIT CFTR

3.85e-041951733199_UP
DrugImipramine hydrochloride [113-52-0]; Down 200; 12.6uM; MCF7; HT_HG-U133A

NF2 LYN VPS13D

3.91e-041961731685_DN
DrugLactobionic acid [96-82-2]; Down 200; 11.2uM; PC3; HT_HG-U133A

LYN CRISPLD2 VPS13D

3.91e-041961736605_DN
DrugAminohippuric acid [61-78-9]; Up 200; 20.6uM; MCF7; HT_HG-U133A

NF2 KIT VPS13D

3.91e-041961736453_UP
DrugCinchonine [118-10-5]; Up 200; 13.6uM; HL60; HT_HG-U133A

NF2 KIT STAB2

3.91e-041961732133_UP
DrugClorsulon [60200-06-8]; Up 200; 10.6uM; MCF7; HT_HG-U133A

NF2 KIT VPS13D

3.91e-041961732884_UP
DrugSulfacetamide sodic hydrate [6209-17-2]; Down 200; 15.8uM; MCF7; HT_HG-U133A

NF2 LYN VPS13D

3.91e-041961731695_DN
DrugTremorine dihydrochloride [300-68-5]; Up 200; 15uM; MCF7; HT_HG-U133A

NF2 LYN VPS13D

3.91e-041961736273_UP
DrugQuipazine dimaleate salt [4774-24-7]; Up 200; 9uM; PC3; HT_HG-U133A

KIT COBL STAB2

3.97e-041971735887_UP
DrugDydrogesterone [152-62-5]; Up 200; 12.8uM; HL60; HT_HG-U133A

CRISPLD2 VPS13D STAB2

3.97e-041971732156_UP
DrugChlorphensin carbamate [886-74-8]; Up 200; 16.2uM; MCF7; HT_HG-U133A

COBL VPS13D CFTR

3.97e-041971737472_UP
DrugAscorbic acid [50-81-7]; Up 200; 22.4uM; PC3; HT_HG-U133A

NF2 VPS13D STAB2

3.97e-041971736306_UP
DrugClopamide [636-54-4]; Down 200; 11.6uM; MCF7; HT_HG-U133A

NF2 CRISPLD2 VPS13D

3.97e-041971735402_DN
DrugRauwolscine hydrochloride [6211-32-1]; Down 200; 10.2uM; PC3; HT_HG-U133A

NF2 COBL VPS13D

3.97e-041971735800_DN
DrugTrifluoperazine dihydrochloride [440-17-5]; Down 200; 8.4uM; HL60; HT_HG-U133A

NF2 CRISPLD2 VPS13D

3.97e-041971732389_DN
DrugDinoprost trometamol [38362-01-5]; Down 200; 8.4uM; MCF7; HT_HG-U133A

LYN VPS13D STAB2

3.97e-041971733308_DN
DrugNeomycin sulfate [1405-10-3]; Up 200; 4.2uM; MCF7; HT_HG-U133A

NF2 VPS13D CFTR

3.97e-041971732229_UP
DrugVigabatrin [60643-86-9]; Up 200; 31uM; PC3; HT_HG-U133A

NF2 LYN VPS13D

3.97e-041971736314_UP
DrugSuramin sodium salt; Up 200; 10uM; PC3; HT_HG-U133A

NF2 COBL VPS13D

3.97e-041971737529_UP
Drugprostaglandin E2; Up 200; 10uM; MCF7; HT_HG-U133A

NF2 LYN VPS13D

4.03e-041981736552_UP
Drug16, 16-dimethylprostaglandin E2 methyl acetate solution; Up 200; 10uM; MCF7; HT_HG-U133A

NF2 LYN VPS13D

4.03e-041981736597_UP
Drug5155877; Down 200; 10uM; PC3; HT_HG-U133A

NF2 COBL VPS13D

4.03e-041981736544_DN
DrugAltretamine [654-05-6]; Up 200; 19uM; MCF7; HT_HG-U133A

NF2 KIT VPS13D

4.03e-041981736467_UP
DrugFluorocurarine chloride [22273-09-2]; Down 200; 11.6uM; MCF7; HT_HG-U133A

LYN VPS13D STAB2

4.03e-041981736083_DN
DrugCyclizine hydrochloride [303-25-3]; Down 200; 13.2uM; HL60; HG-U133A

NF2 LYN VPS13D

4.03e-041981731731_DN
DrugMeclozine dihydrochloride [1104-22-9]; Up 200; 8.6uM; HL60; HT_HG-U133A

NF2 VPS13D STAB2

4.03e-041981732424_UP
DrugPirenperone [ 75444-65-4]; Down 200; 10.2uM; HL60; HT_HG-U133A

NF2 CRISPLD2 VPS13D

4.03e-041981732455_DN
DrugIsoxicam [34552-84-6]; Up 200; 12uM; PC3; HT_HG-U133A

NF2 LYN VPS13D

4.03e-041981737268_UP
DrugHydralazine hydrochloride [304-20-1]; Down 200; 20.4uM; PC3; HT_HG-U133A

NF2 CRISPLD2 VPS13D

4.03e-041981734282_DN
Drugestradiol, USP; Up 200; 0.01uM; PC3; HT_HG-U133A

NF2 COBL VPS13D

4.03e-041981731241_UP
DrugIopamidol [60166-93-0]; Down 200; 5.2uM; PC3; HT_HG-U133A

NF2 COBL VPS13D

4.09e-041991735832_DN
DrugICI 182,780; Down 200; 1uM; PC3; HT_HG-U133A

NF2 CRISPLD2 VPS13D

4.09e-041991731205_DN
DrugIopanoic acid [96-83-3]; Up 200; 7uM; MCF7; HT_HG-U133A

NF2 KIT VPS13D

4.09e-041991735448_UP
DrugMeptazinol hydrochloride [59263-76-2]; Up 200; 14.8uM; MCF7; HT_HG-U133A

NF2 KIT VPS13D

4.09e-041991734774_UP
DrugNorethynodrel [68-23-5]; Down 200; 13.4uM; MCF7; HT_HG-U133A

LYN COBL VPS13D

4.09e-041991737471_DN
DrugCoralyne chloride hydrate [38989-38-7]; Up 200; 9.6uM; PC3; HT_HG-U133A

NF2 CRISPLD2 VPS13D

4.09e-041991736317_UP
DrugAmpicillin trihydrate [7177-48-2]; Up 200; 10uM; PC3; HT_HG-U133A

NF2 VPS13D STAB2

4.09e-041991736307_UP
DrugFluticasone propionate [80474-14-2]; Up 200; 8uM; MCF7; HT_HG-U133A

NF2 COBL VPS13D

4.09e-041991737348_UP
DrugCefuroxime sodium salt [56238-63-2]; Down 200; 9uM; PC3; HT_HG-U133A

NF2 COBL VPS13D

4.09e-041991735787_DN
DrugNadide [53-84-9]; Down 200; 6uM; PC3; HT_HG-U133A

NF2 LYN VPS13D

4.15e-042001735873_DN
Drugcolchicine; Up 200; 0.1uM; MCF7; HG-U133A

NF2 LYN VPS13D

4.15e-04200173644_UP
Drugphosphoramide mustard

PRKDC CFTR

4.65e-0443172ctd:C030090
Drugaxitinib

KIT PRKDC

5.10e-0445172CID006450551
DrugAC1L9IGI

LYN PRKDC

5.10e-0445172CID000445720
Drug2D7

LYN KIT

6.04e-0449172CID005327103
DrugU nu

NF2 PRKDC

6.55e-0451172CID000023943
DiseaseLung diseases

CRISPLD2 KIT PRKDC

1.18e-0578173C0024115
Diseasegastrointestinal stromal tumor (is_implicated_in)

NF2 KIT

1.71e-0511172DOID:9253 (is_implicated_in)
Diseasemultiple sclerosis symptom measurement

CRISPLD2 STAB2

3.19e-0446172EFO_0803536
Diseasegranulocyte count

LYN KIT NBPF7P

3.92e-04254173EFO_0007987
Diseasecarcinoma (implicated_via_orthology)

LYN KIT

6.17e-0464172DOID:305 (implicated_via_orthology)
DiseaseAdenocarcinoma of large intestine

KIT PRKDC

1.38e-0396172C1319315

Protein segments in the cluster

PeptideGeneStartEntry
SVKAYCWEEAMEKMI

CFTR

271

P13569
CFEENMDWKMISDNY

ABCA13

676

Q86UQ4
HAMEKMEEFVCKVWE

ADIPOR2

86

Q86V24
PAEMYDIMKTCWDAD

KIT

896

P10721
NMEYMTWDDELEKSA

CRISPLD2

76

Q9H0B8
AEMEFNCEMKWKGKD

NF2

31

P35240
MDIMDYCKKEWRGNT

OTULIN

86

Q96BN8
EWKCAFMETSAKMNY

DIRAS1

141

O95057
MKYKDKWATDQEDCS

COBL

426

O75128
ELYDIMKMCWKEKAE

LYN

471

P07948
EDSWPSDMCKKMFEV

PNLIPRP2

101

P54317
DTKYCWKDEKDERMS

NBPF7P

376

P0C2Y1
KETCEMDWSDKMEAY

TEKT4

196

Q8WW24
MDWSDKMEAYNIDET

TEKT4

201

Q8WW24
KSEMWDVFCYRMKDV

STAB2

2281

Q8WWQ8
SDEMMKSYVAWDREK

PRKDC

876

P78527
MCDMKKWDQFYSEVL

UGT2B28

226

Q9BY64
KESWMADYCKDDKDI

VPS13D

2816

Q5THJ4