Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	chloride transmembrane transporter activity	TTYH1 ANO5 CLCNKA CLCNKB SLC18A1 SLC4A2	1.72e-07	125	40	6	GO:0015108
GeneOntologyMolecularFunction	monoatomic anion transmembrane transporter activity	TTYH1 ANO5 CLCNKA CLCNKB SLC18A1 SLC4A2	5.25e-07	151	40	6	GO:0008509
GeneOntologyMolecularFunction	inorganic anion transmembrane transporter activity	TTYH1 ANO5 CLCNKA CLCNKB SLC18A1 SLC4A2	1.09e-06	171	40	6	GO:0015103
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	PTCH2 IL10RB NPFFR2 P2RY14 CYSLTR2 GPR171 OR10AG1 HTR1E PTCH1 SSTR2 OR51B2 OR9A2	8.40e-06	1353	40	12	GO:0004888
GeneOntologyMolecularFunction	hedgehog receptor activity	PTCH2 PTCH1	1.17e-05	3	40	2	GO:0008158
GeneOntologyMolecularFunction	smoothened binding	PTCH2 PTCH1	2.34e-05	4	40	2	GO:0005119
GeneOntologyMolecularFunction	hedgehog family protein binding	PTCH2 PTCH1	2.34e-05	4	40	2	GO:0097108
GeneOntologyMolecularFunction	chloride channel activity	TTYH1 ANO5 CLCNKA CLCNKB	2.60e-05	86	40	4	GO:0005254
GeneOntologyMolecularFunction	G protein-coupled receptor activity	NPFFR2 P2RY14 CYSLTR2 GPR171 OR10AG1 HTR1E SSTR2 OR51B2 OR9A2	4.97e-05	884	40	9	GO:0004930
GeneOntologyMolecularFunction	monoatomic anion channel activity	TTYH1 ANO5 CLCNKA CLCNKB	5.29e-05	103	40	4	GO:0005253
GeneOntologyMolecularFunction	G protein-coupled peptide receptor activity	NPFFR2 CYSLTR2 GPR171 SSTR2	1.43e-04	133	40	4	GO:0008528
GeneOntologyMolecularFunction	intramembrane lipid transporter activity	ATP8B3 ANO5 ATP8B4	1.45e-04	51	40	3	GO:0140303
GeneOntologyMolecularFunction	neuropeptide receptor activity	NPFFR2 GPR171 SSTR2	1.63e-04	53	40	3	GO:0008188
GeneOntologyMolecularFunction	peptide receptor activity	NPFFR2 CYSLTR2 GPR171 SSTR2	1.74e-04	140	40	4	GO:0001653
GeneOntologyMolecularFunction	voltage-gated chloride channel activity	CLCNKA CLCNKB	2.13e-04	11	40	2	GO:0005247
GeneOntologyMolecularFunction	G protein-coupled purinergic nucleotide receptor activity	P2RY14 GPR171	3.01e-04	13	40	2	GO:0045028
GeneOntologyMolecularFunction	voltage-gated monoatomic anion channel activity	CLCNKA CLCNKB	5.22e-04	17	40	2	GO:0008308
GeneOntologyMolecularFunction	intracellularly calcium-gated chloride channel activity	TTYH1 ANO5	7.27e-04	20	40	2	GO:0005229
GeneOntologyMolecularFunction	intracellularly calcium-gated channel activity	TTYH1 ANO5	7.27e-04	20	40	2	GO:0141147
GeneOntologyMolecularFunction	nucleotide receptor activity	P2RY14 GPR171	8.81e-04	22	40	2	GO:0016502
GeneOntologyMolecularFunction	purinergic nucleotide receptor activity	P2RY14 GPR171	8.81e-04	22	40	2	GO:0001614
GeneOntologyMolecularFunction	ATPase-coupled intramembrane lipid transporter activity	ATP8B3 ATP8B4	1.43e-03	28	40	2	GO:0140326
GeneOntologyMolecularFunction	neuropeptide binding	GPR171 SSTR2	2.49e-03	37	40	2	GO:0042923
GeneOntologyMolecularFunction	transporter activity	TTYH1 ATP8B3 ANO5 ATP8B4 CLCNKA CLCNKB SLC18A1 SLC4A2	3.55e-03	1289	40	8	GO:0005215
GeneOntologyMolecularFunction	inorganic molecular entity transmembrane transporter activity	TTYH1 ANO5 CLCNKA CLCNKB SLC18A1 SLC4A2	3.74e-03	758	40	6	GO:0015318
GeneOntologyMolecularFunction	gated channel activity	TTYH1 ANO5 CLCNKA CLCNKB	4.37e-03	334	40	4	GO:0022836
GeneOntologyMolecularFunction	ligand-gated monoatomic anion channel activity	TTYH1 ANO5	4.51e-03	50	40	2	GO:0099095
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	TTYH1 ANO5 CLCNKA CLCNKB SLC18A1 SLC4A2	4.66e-03	793	40	6	GO:0015075
GeneOntologyMolecularFunction	lipid transporter activity	ATP8B3 ANO5 ATP8B4	7.05e-03	196	40	3	GO:0005319
GeneOntologyMolecularFunction	phospholipid transporter activity	ATP8B3 ANO5	9.65e-03	74	40	2	GO:0005548
GeneOntologyBiologicalProcess	chloride transmembrane transport	TTYH1 ANO5 CLCNKA CLCNKB SLC4A2	2.44e-06	112	40	5	GO:1902476
GeneOntologyBiologicalProcess	chloride transport	TTYH1 ANO5 CLCNKA CLCNKB SLC4A2	4.70e-06	128	40	5	GO:0006821
GeneOntologyBiologicalProcess	inorganic anion transmembrane transport	TTYH1 ANO5 CLCNKA CLCNKB SLC4A2	5.89e-06	134	40	5	GO:0098661
GeneOntologyBiologicalProcess	monoatomic anion transmembrane transport	TTYH1 ANO5 CLCNKA CLCNKB SLC4A2	1.12e-05	153	40	5	GO:0098656
GeneOntologyBiologicalProcess	inorganic anion transport	TTYH1 ANO5 CLCNKA CLCNKB SLC4A2	2.46e-05	180	40	5	GO:0015698
GeneOntologyBiologicalProcess	monoatomic anion transport	TTYH1 ANO5 CLCNKA CLCNKB SLC4A2	2.66e-05	183	40	5	GO:0006820
GeneOntologyBiologicalProcess	epidermal cell fate specification	PTCH2 PTCH1	5.47e-05	6	40	2	GO:0009957
GeneOntologyBiologicalProcess	neuropeptide signaling pathway	NPFFR2 CYSLTR2 GPR171 SSTR2	9.62e-05	124	40	4	GO:0007218
GeneOntologyBiologicalProcess	transepithelial chloride transport	CLCNKA CLCNKB	1.63e-04	10	40	2	GO:0030321
GeneOntologyBiologicalProcess	phospholipid translocation	ATP8B3 SLC66A2 ATP8B4	1.65e-04	55	40	3	GO:0045332
GeneOntologyBiologicalProcess	lipid translocation	ATP8B3 SLC66A2 ATP8B4	2.14e-04	60	40	3	GO:0034204
GeneOntologyBiologicalProcess	regulation of membrane lipid distribution	ATP8B3 SLC66A2 ATP8B4	2.72e-04	65	40	3	GO:0097035
GeneOntologyBiologicalProcess	G protein-coupled purinergic nucleotide receptor signaling pathway	P2RY14 GPR171	2.82e-04	13	40	2	GO:0035589
GeneOntologyCellularComponent	chloride channel complex	TTYH1 CLCNKA CLCNKB	1.77e-04	57	40	3	GO:0034707
GeneOntologyCellularComponent	trans-Golgi network	ATP8B3 SLC66A2 ATP8B4 GGA2 BIRC6	2.81e-04	306	40	5	GO:0005802
GeneOntologyCellularComponent	phospholipid-translocating ATPase complex	ATP8B3 ATP8B4	3.20e-04	14	40	2	GO:1990531
GeneOntologyCellularComponent	Golgi apparatus subcompartment	ATP8B3 SLC66A2 ATP8B4 GGA2 BIRC6	1.49e-03	443	40	5	GO:0098791
HumanPheno	Odontogenic keratocysts of the jaw	PTCH2 PTCH1	2.42e-05	3	15	2	HP:0010603
HumanPheno	Cardiac fibroma	PTCH2 PTCH1	2.42e-05	3	15	2	HP:0010617
HumanPheno	Ovarian fibroma	PTCH2 PTCH1	2.42e-05	3	15	2	HP:0010618
HumanPheno	Bridged sella turcica	PTCH2 PTCH1	2.42e-05	3	15	2	HP:0005449
HumanPheno	Hypokalemic hypochloremic metabolic alkalosis	CLCNKA CLCNKB	2.42e-05	3	15	2	HP:0004909
HumanPheno	Hypochloremic metabolic alkalosis	CLCNKA CLCNKB	4.84e-05	4	15	2	HP:0005977
HumanPheno	Plantar pits	PTCH2 PTCH1	4.84e-05	4	15	2	HP:0010612
HumanPheno	Abnormal urine chloride concentration	CLCNKA CLCNKB	8.05e-05	5	15	2	HP:0012600
HumanPheno	Hyperchloriduria	CLCNKA CLCNKB	8.05e-05	5	15	2	HP:0002914
HumanPheno	Hyperprostaglandinuria	CLCNKA CLCNKB	1.21e-04	6	15	2	HP:0003527
HumanPheno	Abnormal circulating prostaglandin circulation	CLCNKA CLCNKB	1.21e-04	6	15	2	HP:0011023
HumanPheno	Chronic kidney disease	PKHD1 SRCAP CLCNKA CLCNKB SLC4A2	1.67e-04	194	15	5	HP:0012622
HumanPheno	Hypochloremia	CLCNKA CLCNKB	1.69e-04	7	15	2	HP:0003113
HumanPheno	Calcification of falx cerebri	PTCH2 PTCH1	1.69e-04	7	15	2	HP:0005462
HumanPheno	Impaired renal concentrating ability	CLCNKA CLCNKB	1.69e-04	7	15	2	HP:0004727
HumanPheno	Nasogastric tube feeding	SRCAP CLCNKA CLCNKB	2.21e-04	42	15	3	HP:0040288
HumanPheno	Hyperactive renin-angiotensin system	CLCNKA CLCNKB	2.24e-04	8	15	2	HP:0000841
HumanPheno	Odontogenic neoplasm	PTCH2 PTCH1	2.24e-04	8	15	2	HP:0100612
HumanPheno	Abnormal circulating unsaturated fatty acid concentration	CLCNKA CLCNKB	2.24e-04	8	15	2	HP:0011022
HumanPheno	Abnormal circulating eicosanoid concentration	CLCNKA CLCNKB	2.24e-04	8	15	2	HP:0030361
HumanPheno	Acute kidney injury	PKHD1 CLCNKA CLCNKB	2.55e-04	44	15	3	HP:0001919
HumanPheno	Tube feeding	SRCAP PTCH1 CLCNKA CLCNKB DEGS1	2.71e-04	215	15	5	HP:0033454
HumanPheno	Impaired renal function	CLCNKA CLCNKB	2.88e-04	9	15	2	HP:0000087
HumanPheno	Hypokalemic metabolic alkalosis	CLCNKA CLCNKB	2.88e-04	9	15	2	HP:0001960
HumanPheno	Minor hand anomalies	PTCH2 PTCH1	2.88e-04	9	15	2	HP:0003098
HumanPheno	Increased urinary potassium	CLCNKA CLCNKB	2.88e-04	9	15	2	HP:0003081
HumanPheno	Palmar pits	PTCH2 PTCH1	2.88e-04	9	15	2	HP:0010610
HumanPheno	Hypernatriuria	CLCNKA CLCNKB	3.59e-04	10	15	2	HP:0012605
HumanPheno	Stage 5 chronic kidney disease	PKHD1 SRCAP CLCNKA CLCNKB	5.13e-04	135	15	4	HP:0003774
HumanPheno	Hypokalemic alkalosis	CLCNKA CLCNKB	5.25e-04	12	15	2	HP:0001949
HumanPheno	Fetal polyuria	CLCNKA CLCNKB	5.25e-04	12	15	2	HP:0001563
HumanPheno	Hyponatremia	PKHD1 CLCNKA CLCNKB	6.39e-04	60	15	3	HP:0002902
HumanPheno	Neoplasm of the heart	PTCH2 PTCH1	8.31e-04	15	15	2	HP:0100544
HumanPheno	Abnormal blood monovalent inorganic cation concentration	PKHD1 CLCNKA CLCNKB SLC4A2	8.45e-04	154	15	4	HP:0010930
HumanPheno	Digenic inheritance	CLCNKA CLCNKB	9.48e-04	16	15	2	HP:0010984
HumanPheno	Abnormal urine output	PKHD1 CLCNKA CLCNKB	9.63e-04	69	15	3	HP:0012590
HumanPheno	Delayed ability to stand	CLCNKA CLCNKB	1.07e-03	17	15	2	HP:0025335
HumanPheno	Bifid ribs	PTCH2 PTCH1	1.07e-03	17	15	2	HP:0000892
HumanPheno	Severe failure to thrive	CLCNKA CLCNKB	1.07e-03	17	15	2	HP:0001525
HumanPheno	Abnormal blood sodium concentration	PKHD1 CLCNKA CLCNKB	1.09e-03	72	15	3	HP:0010931
HumanPheno	Metabolic alkalosis	CLCNKA CLCNKB	1.21e-03	18	15	2	HP:0200114
HumanPheno	Abnormal urine sodium concentration	CLCNKA CLCNKB	1.21e-03	18	15	2	HP:0012603
HumanPheno	Abnormal urine potassium concentration	CLCNKA CLCNKB	1.21e-03	18	15	2	HP:0012598
HumanPheno	Abnormality of renal excretion	PKHD1 CLCNKA CLCNKB	1.23e-03	75	15	3	HP:0011036
HumanPheno	Vertebral wedging	PTCH2 PTCH1	1.34e-03	19	15	2	HP:0008422
HumanPheno	Anterior rib cupping	PTCH2 PTCH1	1.34e-03	19	15	2	HP:0000907
HumanPheno	Increased circulating renin concentration	CLCNKA CLCNKB	1.34e-03	19	15	2	HP:0000848
HumanPheno	Medulloblastoma	PTCH2 PTCH1	1.34e-03	19	15	2	HP:0002885
HumanPheno	Deformed sella turcica	PTCH2 PTCH1	1.49e-03	20	15	2	HP:0002681
HumanPheno	Generalized osteosclerosis	ANO5 SRCAP SLC4A2	1.59e-03	82	15	3	HP:0005711
HumanPheno	Osteosclerosis	ANO5 SRCAP SLC4A2	1.59e-03	82	15	3	HP:0010738
Domain	Cl_channel-K	CLCNKA CLCNKB	4.47e-06	2	40	2	IPR002250
Domain	TM_rcpt_patched	PTCH2 PTCH1	4.47e-06	2	40	2	IPR004766
Domain	GPCR_Rhodpsn_7TM	NPFFR2 P2RY14 CYSLTR2 GPR171 OR10AG1 HTR1E SSTR2 OR51B2 OR9A2	9.40e-06	670	40	9	IPR017452
Domain	7tm_1	NPFFR2 P2RY14 CYSLTR2 GPR171 OR10AG1 HTR1E SSTR2 OR51B2 OR9A2	1.02e-05	677	40	9	PF00001
Domain	G_PROTEIN_RECEP_F1_1	NPFFR2 P2RY14 CYSLTR2 GPR171 OR10AG1 HTR1E SSTR2 OR51B2 OR9A2	1.12e-05	685	40	9	PS00237
Domain	G_PROTEIN_RECEP_F1_2	NPFFR2 P2RY14 CYSLTR2 GPR171 OR10AG1 HTR1E SSTR2 OR51B2 OR9A2	1.20e-05	691	40	9	PS50262
Domain	GPCR_Rhodpsn	NPFFR2 P2RY14 CYSLTR2 GPR171 OR10AG1 HTR1E SSTR2 OR51B2 OR9A2	1.22e-05	692	40	9	IPR000276
Domain	Cl-channel_core	CLCNKA CLCNKB	1.59e-04	9	40	2	IPR014743
Domain	Ptc/Disp	PTCH2 PTCH1	1.59e-04	9	40	2	IPR003392
Domain	Patched	PTCH2 PTCH1	1.59e-04	9	40	2	PF02460
Domain	-	CLCNKA CLCNKB	1.59e-04	9	40	2	1.10.3080.10
Domain	Voltage_CLC	CLCNKA CLCNKB	1.59e-04	9	40	2	PF00654
Domain	Cl-channel_volt-gated	CLCNKA CLCNKB	1.59e-04	9	40	2	IPR001807
Domain	Hydrolase_3	ATP8B3 ATP8B4	1.99e-04	10	40	2	PF08282
Domain	SSD	PTCH2 PTCH1	3.44e-04	13	40	2	PS50156
Domain	SSD	PTCH2 PTCH1	3.44e-04	13	40	2	IPR000731
Domain	P_typ_ATPase_c	ATP8B3 ATP8B4	4.00e-04	14	40	2	IPR032630
Domain	P-type_ATPase_N	ATP8B3 ATP8B4	4.00e-04	14	40	2	IPR032631
Domain	P-type_ATPase_IV	ATP8B3 ATP8B4	4.00e-04	14	40	2	IPR006539
Domain	PhoLip_ATPase_C	ATP8B3 ATP8B4	4.00e-04	14	40	2	PF16212
Domain	PhoLip_ATPase_N	ATP8B3 ATP8B4	4.00e-04	14	40	2	PF16209
Domain	CBS	CLCNKA CLCNKB	5.27e-04	16	40	2	SM00116
Domain	CBS_dom	CLCNKA CLCNKB	8.29e-04	20	40	2	IPR000644
Domain	CBS	CLCNKA CLCNKB	8.29e-04	20	40	2	PF00571
Domain	CBS	CLCNKA CLCNKB	8.29e-04	20	40	2	PS51371
Domain	7TM_GPCR_Srsx	NPFFR2 HTR1E SSTR2	1.76e-03	112	40	3	SM01381
Domain	-	ATP8B3 ATP8B4	2.13e-03	32	40	2	2.70.150.10
Domain	-	ATP8B3 ATP8B4	2.13e-03	32	40	2	3.40.1110.10
Domain	ATPase_P-typ_cyto_domN	ATP8B3 ATP8B4	2.54e-03	35	40	2	IPR023299
Domain	ATPase_P-typ_P_site	ATP8B3 ATP8B4	2.69e-03	36	40	2	IPR018303
Domain	P_typ_ATPase	ATP8B3 ATP8B4	2.69e-03	36	40	2	IPR001757
Domain	ATPASE_E1_E2	ATP8B3 ATP8B4	2.69e-03	36	40	2	PS00154
Domain	ATPase_P-typ_transduc_dom_A	ATP8B3 ATP8B4	2.84e-03	37	40	2	IPR008250
Domain	E1-E2_ATPase	ATP8B3 ATP8B4	2.84e-03	37	40	2	PF00122
Domain	-	ATP8B3 ATP8B4	8.29e-03	64	40	2	3.40.50.1000
Pathway	REACTOME_ION_CHANNEL_TRANSPORT	TTYH1 ATP8B3 ANO5 ATP8B4 CLCNKA CLCNKB	1.98e-06	176	31	6	MM15718
Pathway	REACTOME_ION_CHANNEL_TRANSPORT	TTYH1 ATP8B3 ANO5 ATP8B4 CLCNKA CLCNKB	2.48e-06	183	31	6	M997
Pathway	WP_GPCRS_CLASS_A_RHODOPSINLIKE	NPFFR2 P2RY14 CYSLTR2 GPR171 HTR1E SSTR2	1.86e-05	260	31	6	M39397
Pathway	REACTOME_GPCR_LIGAND_BINDING	PTCH2 NPFFR2 P2RY14 CYSLTR2 HTR1E PTCH1 SSTR2	5.22e-05	463	31	7	M507
Pathway	REACTOME_STIMULI_SENSING_CHANNELS	TTYH1 ANO5 CLCNKA CLCNKB	6.23e-05	99	31	4	MM14910
Pathway	REACTOME_STIMULI_SENSING_CHANNELS	TTYH1 ANO5 CLCNKA CLCNKB	8.13e-05	106	31	4	M27200
Pathway	REACTOME_TRANSPORT_OF_SMALL_MOLECULES	TTYH1 ATP8B3 ANO5 ATP8B4 CLCNKA CLCNKB SLC18A1 SLC4A2	8.34e-05	681	31	8	MM14985
Pathway	REACTOME_GLI_PROTEINS_BIND_PROMOTERS_OF_HH_RESPONSIVE_GENES_TO_PROMOTE_TRANSCRIPTION	PTCH2 PTCH1	9.76e-05	7	31	2	M27501
Pathway	REACTOME_TRANSPORT_OF_SMALL_MOLECULES	TTYH1 ATP8B3 ANO5 ATP8B4 CLCNKA CLCNKB SLC18A1 SLC4A2	1.43e-04	736	31	8	M27287
Pathway	KEGG_MEDICUS_REFERENCE_HEDGEHOG_SIGNALING_PATHWAY_PTCH_CORECEPTOR	PTCH2 PTCH1	1.67e-04	9	31	2	M47893
Pathway	KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	NPFFR2 P2RY14 CYSLTR2 HTR1E SSTR2	2.90e-04	272	31	5	M13380
Pathway	KEGG_MEDICUS_REFERENCE_HEDGEHOG_SIGNALING_PATHWAY	PTCH2 PTCH1	4.19e-04	14	31	2	M47414
Pathway	WP_HEDGEHOG_SIGNALING_WP47	PTCH2 PTCH1	5.51e-04	16	31	2	M39675
Pathway	REACTOME_SIGNALING_BY_GPCR	PTCH2 NPFFR2 P2RY14 CYSLTR2 HTR1E PTCH1 SSTR2	6.79e-04	702	31	7	M746
Pathway	REACTOME_CLASS_A_1_RHODOPSIN_LIKE_RECEPTORS	NPFFR2 P2RY14 CYSLTR2 HTR1E SSTR2	7.02e-04	330	31	5	M18334
Pathway	PID_HEDGEHOG_2PATHWAY	PTCH2 PTCH1	1.05e-03	22	31	2	M211
Pathway	WP_HEDGEHOG_SIGNALING_PATHWAY	PTCH2 PTCH1	1.05e-03	22	31	2	MM15924
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_PTCH1_TO_HEDGEHOG_SIGNALING_PATHWAY	PTCH2 PTCH1	1.83e-03	29	31	2	M47372
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_SMO_TO_HEDGEHOG_SIGNALING_PATHWAY	PTCH2 PTCH1	1.83e-03	29	31	2	M47377
Pathway	WP_GPCRS_NONODORANT	NPFFR2 P2RY14 CYSLTR2 SSTR2	2.61e-03	266	31	4	MM15843
Pathway	WP_HEDGEHOG_SIGNALING_WP4249	PTCH2 PTCH1	4.00e-03	43	31	2	M39706
Pubmed	Cloning, tissue distribution, and intrarenal localization of ClC chloride channels in human kidney.	CLCNKA CLCNKB	1.29e-06	2	40	2	8544406
Pubmed	Inherited rare and common variants in PTCH1 and PTCH2 contributing to the predisposition to reproductive cancers.	PTCH2 PTCH1	1.29e-06	2	40	2	34990798
Pubmed	The ClC-K2 Chloride Channel Is Critical for Salt Handling in the Distal Nephron.	CLCNKA CLCNKB	1.29e-06	2	40	2	27335120
Pubmed	Assignment of the genes encoding the human chloride channels, CLCNKA and CLCNKB, to 1p36 and of CLCN3 to 4q32-q33 by in situ hybridization.	CLCNKA CLCNKB	1.29e-06	2	40	2	8812470
Pubmed	A regulatory calcium-binding site at the subunit interface of CLC-K kidney chloride channels.	CLCNKA CLCNKB	1.29e-06	2	40	2	20805576
Pubmed	Associations between CLCNKA_B tag SNPs with essential hypertension and interactions between genetic and environmental factors in an island population in China.	CLCNKA CLCNKB	1.29e-06	2	40	2	25919862
Pubmed	Targeting kidney CLC-K channels: pharmacological profile in a human cell line versus Xenopus oocytes.	CLCNKA CLCNKB	1.29e-06	2	40	2	24863058
Pubmed	Overt nephrogenic diabetes insipidus in mice lacking the CLC-K1 chloride channel.	CLCNKA CLCNKB	1.29e-06	2	40	2	9916798
Pubmed	Kidney kinetics and chloride ion pumps.	CLCNKA CLCNKB	1.29e-06	2	40	2	9916791
Pubmed	[Studies on keratocystic odontogenic tumors].	PTCH2 PTCH1	1.29e-06	2	40	2	19221557
Pubmed	Ptch2 loss drives myeloproliferation and myeloproliferative neoplasm progression.	PTCH2 PTCH1	1.29e-06	2	40	2	26834157
Pubmed	The protein-specific activities of the transmembrane modules of Ptch1 and Ptch2 are determined by their adjacent protein domains.	PTCH2 PTCH1	1.29e-06	2	40	2	30166346
Pubmed	Salt wasting and deafness resulting from mutations in two chloride channels.	CLCNKA CLCNKB	1.29e-06	2	40	2	15044642
Pubmed	Congenital embryonal rhabdomyosarcoma caused by heterozygous concomitant PTCH1 and PTCH2 germline mutations.	PTCH2 PTCH1	1.29e-06	2	40	2	29230040
Pubmed	Expanding Genotype-Phenotype Correlation of CLCNKA and CLCNKB Variants Linked to Hearing Loss.	CLCNKA CLCNKB	1.29e-06	2	40	2	38069401
Pubmed	Two highly homologous members of the ClC chloride channel family in both rat and human kidney.	CLCNKA CLCNKB	1.29e-06	2	40	2	8041726
Pubmed	A cytoplasmic domain mutation in ClC-Kb affects long-distance communication across the membrane.	CLCNKA CLCNKB	1.29e-06	2	40	2	18648499
Pubmed	Cl(-) channels in basolateral TAL membranes XV. Molecular heterogeneity between cortical and medullary channels.	CLCNKA CLCNKB	1.29e-06	2	40	2	11014860
Pubmed	Human CLC-K Channels Require Palmitoylation of Their Accessory Subunit Barttin to Be Functional.	CLCNKA CLCNKB	3.87e-06	3	40	2	26013830
Pubmed	Ptch2 mediates the Shh response in Ptch1-/- cells.	PTCH2 PTCH1	3.87e-06	3	40	2	25085974
Pubmed	Barttin increases surface expression and changes current properties of ClC-K channels.	CLCNKA CLCNKB	3.87e-06	3	40	2	12111250
Pubmed	Barttin is a Cl- channel beta-subunit crucial for renal Cl- reabsorption and inner ear K+ secretion.	CLCNKA CLCNKB	3.87e-06	3	40	2	11734858
Pubmed	Common genetic variants and haplotypes in renal CLCNKA gene are associated to salt-sensitive hypertension.	CLCNKA CLCNKB	3.87e-06	3	40	2	17510212
Pubmed	Barttin modulates trafficking and function of ClC-K channels.	CLCNKA CLCNKB	3.87e-06	3	40	2	16849430
Pubmed	Functionally Distinctive Ptch Receptors Establish Multimodal Hedgehog Signaling in the Tooth Epithelial Stem Cell Niche.	PTCH2 PTCH1	3.87e-06	3	40	2	31145830
Pubmed	Mechanisms of Disease: the kidney-specific chloride channels ClCKA and ClCKB, the Barttin subunit, and their clinical relevance.	CLCNKA CLCNKB	3.87e-06	3	40	2	18094726
Pubmed	Transcriptional regulation of the CLC-K1 promoter by myc-associated zinc finger protein and kidney-enriched Krüppel-like factor, a novel zinc finger repressor.	CLCNKA CLCNKB	3.87e-06	3	40	2	10982849
Pubmed	Mechanism of inhibition of the tumor suppressor Patched by Sonic Hedgehog.	PTCH2 PTCH1	3.87e-06	3	40	2	27647915
Pubmed	Ptch2, a second mouse Patched gene is co-expressed with Sonic hedgehog.	PTCH2 PTCH1	3.87e-06	3	40	2	9462734
Pubmed	Haplotype diversity in four genes (CLCNKA, CLCNKB, BSND, NEDD4L) involved in renal salt reabsorption.	CLCNKA CLCNKB	7.73e-06	4	40	2	17652939
Pubmed	[Exploring parent-of-origin effects for non-syndromic cleft lip with or without cleft palate on PTCH1, PTCH2, SHH, SMO genes in Chinese case-parent trios].	PTCH2 PTCH1	7.73e-06	4	40	2	33047712
Pubmed	FIC1, a P-type ATPase linked to cholestatic liver disease, has homologues (ATP8B2 and ATP8B3) expressed throughout the body.	ATP8B3 ATP8B4	7.73e-06	4	40	2	12880872
Pubmed	Fibroblast growth factor 10 is required for proper development of the mouse whiskers.	PTCH2 PTCH1	7.73e-06	4	40	2	12615071
Pubmed	Functions of sorting nexin 17 domains and recognition motif for P-selectin trafficking.	PTCH1 SNX17	7.73e-06	4	40	2	15769472
Pubmed	Overlapping and non-overlapping Ptch2 expression with Shh during mouse embryogenesis.	PTCH2 PTCH1	7.73e-06	4	40	2	9858693
Pubmed	Patched1 and Patched2 inhibit Smoothened non-cell autonomously.	PTCH2 PTCH1	1.29e-05	5	40	2	27552050
Pubmed	Suppression of hair follicle development inhibits induction of sonic hedgehog, patched, and patched-2 in hair germs in mice.	PTCH2 PTCH1	1.29e-05	5	40	2	11758785
Pubmed	Expression of Sonic Hedgehog and pathway components in the embryonic mouse head: anatomical relationships between regulators of positive and negative feedback.	PTCH2 PTCH1	1.29e-05	5	40	2	34353359
Pubmed	Hedgehog and patched gene expression in adult ocular tissues.	PTCH2 PTCH1	1.29e-05	5	40	2	9237688
Pubmed	Multipotent CD15+ cancer stem cells in patched-1-deficient mouse medulloblastoma.	PTCH2 PTCH1	1.93e-05	6	40	2	19487286
Pubmed	Mutations in a novel gene with transmembrane domains underlie Usher syndrome type 3.	P2RY14 GPR171	1.93e-05	6	40	2	11524702
Pubmed	A mouse DRG genetic toolkit reveals morphological and physiological diversity of somatosensory neuron subtypes.	CYSLTR2 SSTR2	1.93e-05	6	40	2	38442711
Pubmed	Impairment in renal medulla development underlies salt wasting in Clc-k2 channel deficiency.	CLCNKA CLCNKB	2.70e-05	7	40	2	34499620
Pubmed	Intrarenal and cellular localization of CLC-K2 protein in the mouse kidney.	CLCNKA CLCNKB	2.70e-05	7	40	2	11423561
Pubmed	Characterization of two patched receptors for the vertebrate hedgehog protein family.	PTCH2 PTCH1	2.70e-05	7	40	2	9811851
Pubmed	CDC50 proteins are critical components of the human class-1 P4-ATPase transport machinery.	ATP8B3 ATP8B4	2.70e-05	7	40	2	20961850
Pubmed	Patched Receptors Sense, Interpret, and Establish an Epidermal Hedgehog Signaling Gradient.	PTCH2 PTCH1	3.60e-05	8	40	2	27498049
Pubmed	Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog.	PTCH2 PTCH1	3.60e-05	8	40	2	10027293
Pubmed	A distinct Smoothened mutation causes severe cerebellar developmental defects and medulloblastoma in a novel transgenic mouse model.	PTCH2 PTCH1	3.60e-05	8	40	2	22869526
Pubmed	Defects in mouse mammary gland development caused by conditional haploinsufficiency of Patched-1.	PTCH2 PTCH1	3.60e-05	8	40	2	10529434
Pubmed	Changing expression of chloride channels during preimplantation mouse development.	CLCNKA CLCNKB	4.62e-05	9	40	2	23115349
Pubmed	A sonic hedgehog signaling domain in the arterial adventitia supports resident Sca1+ smooth muscle progenitor cells.	PTCH2 PTCH1	4.62e-05	9	40	2	18591670
Pubmed	Autonomous and non-autonomous Shh signalling mediate the in vivo growth and guidance of mouse retinal ganglion cell axons.	PTCH2 PTCH1	4.62e-05	9	40	2	18832395
Pubmed	The sonic hedgehog-patched-gli pathway in human development and disease.	PTCH2 PTCH1	4.62e-05	9	40	2	11001584
Pubmed	Patched2 modulates tumorigenesis in patched1 heterozygous mice.	PTCH2 PTCH1	4.62e-05	9	40	2	16849540
Pubmed	A spontaneous mouse mutation, mesenchymal dysplasia (mes), is caused by a deletion of the most C-terminal cytoplasmic domain of patched (ptc).	PTCH2 PTCH1	4.62e-05	9	40	2	11784021
Pubmed	The Shh signalling pathway in early tooth development.	PTCH2 PTCH1	5.77e-05	10	40	2	10512189
Pubmed	In situ hybridization methods for mouse whole mounts and tissue sections with and without additional β-galactosidase staining.	PTCH2 PTCH1	5.77e-05	10	40	2	24318810
Pubmed	Indian hedgehog activates hematopoiesis and vasculogenesis and can respecify prospective neurectodermal cell fate in the mouse embryo.	PTCH2 PTCH1	5.77e-05	10	40	2	11311154
Pubmed	Cholesterol Modification of Smoothened Is Required for Hedgehog Signaling.	PTCH2 PTCH1	5.77e-05	10	40	2	28344083
Pubmed	Runx2 (Cbfa1) inhibits Shh signaling in the lower but not upper molars of mouse embryos and prevents the budding of putative successional teeth.	PTCH2 PTCH1	7.05e-05	11	40	2	15668330
Pubmed	Evidence that preaxial polydactyly in the Doublefoot mutant is due to ectopic Indian Hedgehog signaling.	PTCH2 PTCH1	7.05e-05	11	40	2	9671585
Pubmed	Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation.	PTCH2 PTCH1	7.05e-05	11	40	2	10465785
Pubmed	Genomic characterization of Gli-activator targets in sonic hedgehog-mediated neural patterning.	PTCH2 PTCH1	7.05e-05	11	40	2	17442700
Pubmed	Genetically engineered mouse models of brain cancer and the promise of preclinical testing.	PTCH2 PTCH1	8.45e-05	12	40	2	19076778
Pubmed	Paracrine Hedgehog signaling in stomach and intestine: new roles for hedgehog in gastrointestinal patterning.	PTCH2 PTCH1	8.45e-05	12	40	2	19445942
Pubmed	Cholesterol modification of sonic hedgehog is required for long-range signaling activity and effective modulation of signaling by Ptc1.	PTCH2 PTCH1	8.45e-05	12	40	2	11389830
Pubmed	Attenuated sensing of SHH by Ptch1 underlies evolution of bovine limbs.	PTCH2 PTCH1	8.45e-05	12	40	2	24990743
Pubmed	Hedgehog signaling regulates differentiation from double-negative to double-positive thymocyte.	PTCH2 PTCH1	8.45e-05	12	40	2	10981962
Pubmed	Vsx2/Chx10 ensures the correct timing and magnitude of Hedgehog signaling in the mouse retina.	PTCH2 PTCH1	8.45e-05	12	40	2	18417110
Pubmed	Lhx2 is a progenitor-intrinsic modulator of Sonic Hedgehog signaling during early retinal neurogenesis.	PTCH2 PTCH1	8.45e-05	12	40	2	36459481
Pubmed	A role for Saccharomyces cerevisiae Centrin (Cdc31) in mitochondrial function and biogenesis.	MRPL32 RBCK1	8.45e-05	12	40	2	30251372
Pubmed	Ptch2 shares overlapping functions with Ptch1 in Smo regulation and limb development.	PTCH2 PTCH1	9.98e-05	13	40	2	25448692
Pubmed	Expression patterns of Hedgehog signalling pathway members during mouse palate development.	PTCH2 PTCH1	9.98e-05	13	40	2	16168717
Pubmed	Ptch2/Gas1 and Ptch1/Boc differentially regulate Hedgehog signalling in murine primordial germ cell migration.	PTCH2 PTCH1	9.98e-05	13	40	2	32332736
Pubmed	Differential expression of putative transbilayer amphipath transporters.	ATP8B3 ATP8B4	9.98e-05	13	40	2	11015572
Pubmed	Control of glial precursor cell development in the mouse optic nerve by sonic hedgehog from retinal ganglion cells.	PTCH2 PTCH1	9.98e-05	13	40	2	18625210
Pubmed	Gli2 influences proliferation in the developing lung through regulation of cyclin expression.	PTCH2 PTCH1	9.98e-05	13	40	2	19574535
Pubmed	Critical roles for collagenase-3 (Mmp13) in development of growth plate cartilage and in endochondral ossification.	PTCH2 PTCH1	9.98e-05	13	40	2	15563592
Pubmed	Mice with a targeted mutation of patched2 are viable but develop alopecia and epidermal hyperplasia.	PTCH2 PTCH1	1.16e-04	14	40	2	16914743
Pubmed	Sonic hedgehog regulates branching morphogenesis in the mammalian lung.	PTCH2 PTCH1	1.16e-04	14	40	2	9768363
Pubmed	A predictive model of bifunctional transcription factor signaling during embryonic tissue patterning.	PTCH2 PTCH1	1.34e-04	15	40	2	25458012
Pubmed	Sonic hedgehog signaling is essential for hair development.	PTCH2 PTCH1	1.34e-04	15	40	2	9768360
Pubmed	Essential role for ligand-dependent feedback antagonism of vertebrate hedgehog signaling by PTCH1, PTCH2 and HHIP1 during neural patterning.	PTCH2 PTCH1	1.34e-04	15	40	2	23900540
Pubmed	GATA4 and GATA6 regulate pancreatic endoderm identity through inhibition of hedgehog signaling.	PTCH2 PTCH1	1.53e-04	16	40	2	26932670
Pubmed	Epidermal hyperplasia and expansion of the interfollicular stem cell compartment in mutant mice with a C-terminal truncation of Patched1.	PTCH2 PTCH1	1.53e-04	16	40	2	17631878
Pubmed	Kif7 regulates Gli2 through Sufu-dependent and -independent functions during skin development and tumorigenesis.	PTCH2 PTCH1	1.53e-04	16	40	2	23034632
Pubmed	Sonic hedgehog-dependent activation of Gli2 is essential for embryonic hair follicle development.	PTCH2 PTCH1	1.53e-04	16	40	2	12533516
Pubmed	Ciliary and extraciliary Gpr161 pools repress hedgehog signaling in a tissue-specific manner.	PTCH2 PTCH1	1.53e-04	16	40	2	34346313
Pubmed	Activated Hedgehog-GLI Signaling Causes Congenital Ureteropelvic Junction Obstruction.	PTCH2 PTCH1	1.53e-04	16	40	2	29109083
Pubmed	Aberrant and constitutive expression of FOXL2 impairs ovarian development and functions in mice.	PTCH2 PTCH1	1.73e-04	17	40	2	32945847
Pubmed	Manifestation of the limb prepattern: limb development in the absence of sonic hedgehog function.	PTCH2 PTCH1	1.95e-04	18	40	2	11476582
Pubmed	Ciliary Hedgehog signaling patterns the digestive system to generate mechanical forces driving elongation.	ANO5 PTCH1	1.95e-04	18	40	2	34893605
Pubmed	Sonic hedgehog signaling regulates a novel epithelial progenitor domain of the hindbrain choroid plexus.	PTCH2 PTCH1	1.95e-04	18	40	2	19570847
Pubmed	Cancer Stem Cells Regulate Cancer-Associated Fibroblasts via Activation of Hedgehog Signaling in Mammary Gland Tumors.	PTCH2 PTCH1	2.18e-04	19	40	2	28202523
Pubmed	Coordination of canonical and noncanonical Hedgehog signalling pathways mediated by WDR11 during primordial germ cell development.	PTCH2 PTCH1	2.18e-04	19	40	2	37516749
Pubmed	SRG3, a core component of mouse SWI/SNF complex, is essential for extra-embryonic vascular development.	PTCH2 PTCH1	2.18e-04	19	40	2	18206867
Pubmed	Patched 1 and patched 2 redundancy has a key role in regulating epidermal differentiation.	PTCH2 PTCH1	2.18e-04	19	40	2	24492243
Pubmed	Essential roles of G9a in cell proliferation and differentiation during tooth development.	PTCH2 PTCH1	2.42e-04	20	40	2	28527696
Pubmed	Pinin modulates expression of an intestinal homeobox gene, Cdx2, and plays an essential role for small intestinal morphogenesis.	PTCH2 PTCH1	2.42e-04	20	40	2	20637749
Cytoband	1p36	CLCNKA CLCNKB	7.81e-04	47	40	2	1p36
GeneFamily	Chloride voltage-gated channels	CLCNKA CLCNKB	1.03e-04	10	28	2	302
GeneFamily	ATPase phospholipid transporting	ATP8B3 ATP8B4	2.40e-04	15	28	2	1210
CoexpressionAtlas	B cells, proB.CLP.BM, CD19- IgM- CD43+ CD24intermediate CD45R- AA4.1+ CD, Bone marrow, avg-2	P2RY14 GPR171 ATP8B4 SSTR2 SLC18A1 TET1	7.04e-05	399	38	6	GSM538345_500
CoexpressionAtlas	B cells, proB.CLP.BM, CD19- IgM- CD43+ CD24- AA4.1+ CD45R- CD117+ IL7R+, Bone marrow, avg-1	P2RY14 GPR171 ATP8B4 SSTR2 SLC18A1 TET1	7.64e-05	405	38	6	GSM538343_500
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Mesenchymal-fibroblastic-Stromal_2_(NPY+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PTCH2 ATP8B3 P2RY14 PTCH1	1.47e-05	166	40	4	3b67064a5149e72f895344d938c64b8ff65247f5
ToppCell	facs-Marrow-T-cells-24m-Myeloid-granulocyte_monocyte_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTCH2 TTYH1 DPT ATP8B4	1.58e-05	169	40	4	1558606be0a8bcd4fd0ce609701a1411e4ca2f9f
ToppCell	facs-Marrow-T-cells-24m-Myeloid-granulocyte_monocyte_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTCH2 TTYH1 DPT ATP8B4	1.58e-05	169	40	4	1b2354de1ce4080118d9f01e7c5fd6079e705125
ToppCell	3'-Distal_airway-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.3.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ANO5 CYSLTR2 GGA2 TMEM236	1.85e-05	176	40	4	76fdf211bce101e83a27d822cb399487bd107027
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Immune-Myeloid\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	P2RY14 CYSLTR2 ATP8B4 SLC18A1	2.16e-05	183	40	4	a97f052950429245c3231464271e1ba539863bba
ToppCell	Children_(3_yrs)-Immune-interstitial_macrophage_(C1Q_positive)-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	P2RY14 CYSLTR2 ATP8B4 TMEM236	2.50e-05	190	40	4	2d54fca50593fbd11fe13fc2bfaf937a05db776d
ToppCell	Parenchymal-10x5prime-Epithelial-Epi_airway_neuro-secretory\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	HTR1E CLCNKA CLCNKB SLC18A1	2.71e-05	194	40	4	d024cd75a97f048257e49cee9190fb2e79202ee2
ToppCell	Skin-Tubules\|Skin / Skin and Kidney Cells in Lupus Nephritis Patients.	PKHD1 HTR1E CLCNKA CLCNKB	2.82e-05	196	40	4	12e21cc310a261407b46e034108e8c93ea16e045
ToppCell	Parenchymal-10x5prime-Stromal-Peri/Epineurial_-NAF_endoneurial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	PTCH2 NPFFR2 P2RY14 PTCH1	3.05e-05	200	40	4	8a4c210a3130f7baedf15ecbc0f4903b97da0352
ToppCell	LPS-IL1RA-Lymphocytic_NKT-T_cells-iNKT-MAIT\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	GPR171 ATP8B4 SLC18A1	2.35e-04	134	40	3	92981dc68c1b3cdc53f9cf83386c47f0c6c98ae7
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_submucosal-gland-SMG_Serous\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	PTCH2 TTYH1 TECTA	2.85e-04	143	40	3	92ddc3e3f6ba78dd9daeb272c12503ec2650a874
ToppCell	facs-Lung-Endomucin-24m-Endothelial-Capillary_Type_1_Cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PKHD1 DOCK3 TECTA	2.97e-04	145	40	3	96712c68ab759d7ade0d912581a1a7c25dc6def8
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Mesenchymal-fibroblastic-Stromal_2_(CH25H+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	P2RY14 PTCH1 CLCNKB	3.03e-04	146	40	3	669001b772b6d6109a09727619ed5829122b48db
ToppCell	PND10-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-NK-NK_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CYSLTR2 GPR171 ATP8B4	3.15e-04	148	40	3	3aa47398cb805c6c6e16b375cc3e9c7f04bb91f4
ToppCell	PND03-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-NK-NK_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CYSLTR2 GPR171 ATP8B4	3.28e-04	150	40	3	c18d3f66b384ec9ee0b8fb6a369b9a524b5dcaeb
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	DPT CLCNKA CLCNKB	3.47e-04	153	40	3	0307f10e772021ae68a42690634df458672a6df9
ToppCell	E18.5-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CYSLTR2 GPR171 ATP8B4	3.61e-04	155	40	3	d8e9f355ce933f6383c3d1e35ff55235a95c7fcd
ToppCell	facs-Heart-RA-24m-Lymphocytic-T_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NPFFR2 CYSLTR2 GPR171	3.61e-04	155	40	3	cc3fc379ea78742a216317054f336331f7c7a157
ToppCell	facs-Heart-RA-24m-Lymphocytic-T_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NPFFR2 CYSLTR2 GPR171	3.61e-04	155	40	3	1900a76754e2a9c7117e531c5907b7942f72c4a6
ToppCell	COVID-19-Myeloid-Dendritic_cells\|COVID-19 / group, cell type (main and fine annotations)	CYSLTR2 ATP8B4 HTR1E	3.68e-04	156	40	3	a07a9096799e4ba663841c70035b4b32c1fda4f9
ToppCell	TCGA-Endometrium-Primary_Tumor-Endometrial_Adenocarcinoma-Serous_adenocarcinoma-5\|TCGA-Endometrium / Sample_Type by Project: Shred V9	DOCK3 TECTA CLCNKB	3.75e-04	157	40	3	59450e9f580555091b159fbbe0a0756e51bcd9ad
ToppCell	E18.5-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-NK\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CYSLTR2 GPR171 ATP8B4	3.82e-04	158	40	3	5d926be5a0ebe8257cd552afa7844171f9ff01c0
ToppCell	COPD-Myeloid-DC_Langerhans\|World / Disease state, Lineage and Cell class	P2RY14 ATP8B4 CLCNKB	3.96e-04	160	40	3	1b73a14ad6546d9f2812c19081278a79260abeae
ToppCell	E16.5-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-NK-NK_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PTCH2 GPR171 ATP8B4	3.96e-04	160	40	3	b2d8940ea8c068273b7da1589d3d6ae5110d8209
ToppCell	E16.5-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PTCH2 GPR171 ATP8B4	3.96e-04	160	40	3	9caab1bb63c7e66c44783852ee75b16bb40fa594
ToppCell	E16.5-Immune-Immune_Lymphocytic_T/NK\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PTCH2 GPR171 ATP8B4	3.96e-04	160	40	3	229841be7b984a00a301cd5d88c11226a90d8a88
ToppCell	E16.5-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-NK\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PTCH2 GPR171 ATP8B4	3.96e-04	160	40	3	99c9ae2041445539fada842e1af01368669bfca0
ToppCell	facs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PKHD1 DOCK3 TECTA	4.11e-04	162	40	3	bf886e22ff2a20353499004b53f25fb9e6574896
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L6_IT-L6_IT_ALM_Oprk1\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	IL10RB SSTR2 CLCNKA	4.11e-04	162	40	3	2d28306c6125b31f11ea6d911a167b93a74907c5
ToppCell	saliva-Severe-critical_progression_d28-40-Myeloid-Granulocytic-Neutrophil-Neu_c5-GSTP1(high)OASL(low)\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	P2RY14 GPR171 RBCK1	4.18e-04	163	40	3	d005115aa1e1458b51de7eb719794617a4168608
ToppCell	Children_(3_yrs)-Epithelial-lung_neuroendocrine_cell_(PNEC)-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	DOCK3 ANO5 SLC18A1	4.25e-04	164	40	3	be49af6335f2505065cde2cb9800e4a5516811b1
ToppCell	PCW_07-8.5-Epithelial-Epithelial_ciliated\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	PKHD1 DOCK3 CLCNKB	4.33e-04	165	40	3	82530f96aaefe28a13bad0474bbad043f127a86c
ToppCell	PCW_07-8.5-Epithelial-Epithelial_ciliated-epi_ciliated_(14)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	PKHD1 DOCK3 CLCNKB	4.33e-04	165	40	3	0c714e852f912b5749de4cb0895406673979b2e6
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Mesenchymal-fibroblastic-Stromal_2_(CH25H+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PTCH2 P2RY14 PTCH1	4.41e-04	166	40	3	d1c61270c7b39bb365020eeafe298a8f88aa887e
ToppCell	Adult-Immune-interstitial_macrophage_(C1Q_positive)-D122\|Adult / Lineage, Cell type, age group and donor	P2RY14 ATP8B4 TMEM236	4.41e-04	166	40	3	be284e2e596390f05305c7bcfc316f87b963fc0b
ToppCell	BAL-Severe-Myeloid-cDC-cDC-cDC_2\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	P2RY14 BTN2A2 ATP8B4	4.41e-04	166	40	3	d373f1092e85eeb317a7406032b259f11e6adbe0
ToppCell	droplet-Liver-LIVER-NPC-1m-Myeloid-plasmacytoid_dendritic_cells\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	P2RY14 GPR171 TET1	4.56e-04	168	40	3	e8878ec68b21c8d5694d7209b816d2f869673164
ToppCell	droplet-Liver-LIVER-NPC-1m-Myeloid-plasmacytoid_dendritic_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	P2RY14 GPR171 TET1	4.56e-04	168	40	3	a007758c219d3d5db2b5529f29af63be0d408304
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5-Exc_L5-6_RORB_LINC00320\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NPFFR2 CYSLTR2 SSTR2	4.56e-04	168	40	3	3db0453296914011b733b82234b3e8e45ebc86b6
ToppCell	PCW_05-06-Immune_Lymphocytic-Immune_Lymphocytic_NK/ILC\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	NPFFR2 GPR171 ATP8B4	4.64e-04	169	40	3	45ac692a0c9064ce6b6a31c2cd21c85ccf594670
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Monocytic\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	P2RY14 CYSLTR2 ATP8B4	4.64e-04	169	40	3	b2fdf9f842dc7c181bc951a8a6932c916ed835ef
ToppCell	facs-Skin-Skin_Anagen-18m-Lymphocytic-T_cell\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	P2RY14 CYSLTR2 ATP8B4	4.64e-04	169	40	3	630d921aa8fb5681d06a4e09b833855c374be484
ToppCell	facs-Skin-Skin_Anagen-18m-Lymphocytic-nan\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	P2RY14 CYSLTR2 ATP8B4	4.64e-04	169	40	3	468284d4a3a0557aed04eadb1aba2317babc6904
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Monocytic-Monocyte-derived_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	P2RY14 CYSLTR2 ATP8B4	4.64e-04	169	40	3	2322f03a115c662f808ebfc892192b7d38d48181
ToppCell	5'-Adult-Appendix-Hematopoietic-T_cells-TRGV2_gdT\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DOCK3 GPR171 ATP8B4	4.64e-04	169	40	3	8caf7996796a2e2716e3855de855c903d6126bf2
ToppCell	facs-Skin-Skin_Anagen-18m-Lymphocytic\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	P2RY14 CYSLTR2 ATP8B4	4.64e-04	169	40	3	6f765e142d127545e622fe24b5287cd6e9706ccc
ToppCell	PCW_05-06-Immune_Lymphocytic-Immune_Lymphocytic_NK/ILC-im_natural_killer_[NK]_(1)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	NPFFR2 GPR171 ATP8B4	4.64e-04	169	40	3	3514a74980c7bd4bb76dbd06693f492e8dce21e0
ToppCell	COVID-19-Heart-CM_+_Macrophage\|COVID-19 / Disease (COVID-19 only), tissue and cell type	DOCK3 ANO5 ATP8B4	4.72e-04	170	40	3	3f15242a1d3e4e9871d9170b2ef05842fb609c29
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	P2RY14 PTCH1 CLCNKB	4.72e-04	170	40	3	a7184dc41f90caa753860ed0f65a18133f84bc5f
ToppCell	Nasal_Brush-Epithelial-Ionocytes\|Nasal_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X	ATP8B4 CLCNKA CLCNKB	4.89e-04	172	40	3	dd3a23dc78dc6939f41126f8d7bd23a2e4713647
ToppCell	metastatic_Brain-Myeloid_cells-CD207+CD1a+_LCs\|Myeloid_cells / Location, Cell class and cell subclass	DPT P2RY14 TET1	4.89e-04	172	40	3	38d17e769fe8eac8b57b820490d4ddd969243ee7
ToppCell	Nasal_Brush-Epithelial-Ionocytes\|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X	ATP8B4 CLCNKA CLCNKB	4.89e-04	172	40	3	04fabb40fa9357d8902f3b04adc15231626cd9f8
ToppCell	droplet-Lung-nan-3m-Lymphocytic-B_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPR171 GGA2 SMIM14	4.97e-04	173	40	3	25d72fa7a84baf5660ead6da67327590f5c91860
ToppCell	droplet-Lung-nan-3m-Lymphocytic-B_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPR171 GGA2 SMIM14	4.97e-04	173	40	3	886ac1b98f709ad7131df778b83712bf8ed313de
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PKHD1 CLCNKA CLCNKB	4.97e-04	173	40	3	0c74bdb40e635d906fd180412c23bf7fed61621e
ToppCell	droplet-Lung-30m-Hematologic-myeloid-plasmacytoid_dendritic_cell\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	P2RY14 GPR171 TET1	4.97e-04	173	40	3	4f0c065e876197ad8cae7856669f09e37ecafa3f
ToppCell	droplet-Lung-30m-Hematologic-myeloid-plasmacytoid_dendritic_cell-plasmacytoid_dendritic\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	P2RY14 GPR171 TET1	4.97e-04	173	40	3	9bbea566964281f47bf75d665b7d69ba8326e207
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TTYH1 DPT PTCH1	5.06e-04	174	40	3	9c916af5eebd932f67dc9117e1d26ff194a2ff2c
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TTYH1 DPT PTCH1	5.06e-04	174	40	3	bc71521f44a5fe013af42b06b5d1bd2446ecf3b5
ToppCell	PBMC-Convalescent-Lymphocyte-B-B_cell-B_intermediate-B_intermediate-10\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	BTN2A2 SLC66A2 SMIM14	5.06e-04	174	40	3	59ccc5a82507463e0a316ba6286cb25ec1a4091b
ToppCell	facs-Skin-Telogen-3m-Lymphocytic\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	P2RY14 GPR171 ATP8B4	5.23e-04	176	40	3	7b3f3d9b33770edf294cee0eccaf8a46f9331461
ToppCell	facs-Skin-Telogen-3m-Lymphocytic-T_cell\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	P2RY14 GPR171 ATP8B4	5.23e-04	176	40	3	9c0fb2c6ae84febdf7c3d4e648985f597dcffe7a
ToppCell	facs-Skin-Telogen-3m-Lymphocytic-nan\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	P2RY14 GPR171 ATP8B4	5.23e-04	176	40	3	3d372c1d527fcc118d1e5809f2524fc387682472
ToppCell	10x5'-lymph-node_spleen-Lymphocytic_B-GC_B_(II)\|lymph-node_spleen / Manually curated celltypes from each tissue	GGA2 SSTR2 SMIM14	5.23e-04	176	40	3	5788dd5b23ebb52f19d3b5bdbcfe25dee349cf77
ToppCell	facs-Lung-EPCAM-18m-Myeloid-Myeloid_Dendritic_Type_2\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	P2RY14 GPR171 ATP8B4	5.31e-04	177	40	3	3cb96d7d56c9ff90f1f8a6caaf49e580e2524c7d
ToppCell	10x3'2.3-week_17-19-Lymphocytic_T-T_NK-NK_T_cell\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	P2RY14 GPR171 PTCH1	5.40e-04	178	40	3	a34bb693b72684cbd97ac9efff77d2d14e41be75
ToppCell	droplet-Tongue-nan-24m-Myeloid-basal_cell\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CYSLTR2 GPR171 ATP8B4	5.40e-04	178	40	3	9423e209de94d26e96117581c95dc069850225d3
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	P2RY14 ATP8B4 SLC18A1	5.40e-04	178	40	3	24e8c62060455159235985f456af0c5023a7f3f5
ToppCell	facs-Lung-ENDOMUCIN-18m-Lymphocytic-B_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPR171 GGA2 SMIM14	5.40e-04	178	40	3	ba5a477257877f4a15a91c1762ffcc6f2e9f7357
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Macrophage_Dendritic\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	P2RY14 ATP8B4 SLC18A1	5.40e-04	178	40	3	4f1cc954d4d9b5b2b75a4cf995ba81e2ada27084
ToppCell	facs-Lung-ENDOMUCIN-18m-Lymphocytic-B_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPR171 GGA2 SMIM14	5.40e-04	178	40	3	5634c1fbc817758092af4feafff94d107412d89b
ToppCell	facs-Lung-18m-Hematologic-myeloid-myeloid_dendritic_cell-dendritic_type_2\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	P2RY14 GPR171 ATP8B4	5.49e-04	179	40	3	b7a2429d07d7146b32b3552a5f2a2542105a71e0
ToppCell	PCW_13-14-Hematologic_Myeloid-Hem_Myeloid_dendritic-im_conventional_dendritic_(19)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	P2RY14 GPR171 ATP8B4	5.49e-04	179	40	3	9fc44637c9a7551fd47b8533e45a9c199e164a95
ToppCell	droplet-Lung-LUNG-1m-Lymphocytic-B_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPR171 GGA2 SMIM14	5.58e-04	180	40	3	e5bbd0e204da4f98254e3484b383ec1c277b4209
ToppCell	droplet-Lung-LUNG-1m-Lymphocytic-B_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPR171 GGA2 SMIM14	5.58e-04	180	40	3	b51b10781082bc0305ba6a81e978729b329f7771
ToppCell	droplet-Lung-LUNG-30m-Lymphocytic-B_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPR171 GGA2 SMIM14	5.67e-04	181	40	3	46de8c18e4ec8dc9d07f7c8cc7b5f48b9c613aae
ToppCell	droplet-Lung-30m-Hematologic-lymphocytic-B_cell\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	GPR171 GGA2 SMIM14	5.67e-04	181	40	3	477c572c5c1efceee49732cc9e8b1dad68a7e6e5
ToppCell	COVID-19-Epithelial-Ionocytes\|Epithelial / Condition, Lineage and Cell class	DOCK3 CLCNKA CLCNKB	5.67e-04	181	40	3	4a8d4f2709c1b25f908867f1b2fae1d2d0abf1d4
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_D_(IT_RORB_THEMIS_LINC00507)_6-Exc_L6_THEMIS_LINC00343\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NPFFR2 HTR1E SSTR2	5.67e-04	181	40	3	9de2f2cc5f02e0ca599c9e0d2cb1e1e4b5aac112
ToppCell	droplet-Lung-30m-Hematologic-lymphocytic-B_cell-B_cell\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	GPR171 GGA2 SMIM14	5.67e-04	181	40	3	909280b44085d8e96fcd3cbcba6bff94badd41e8
ToppCell	droplet-Lung-LUNG-30m-Lymphocytic-B_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPR171 GGA2 SMIM14	5.67e-04	181	40	3	ce0e39114bf3bcbcce0fd4c0d70bedadd0853e1d
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NPFFR2 HTR1E SSTR2	5.76e-04	182	40	3	205d9ad1ea4b7adee8054496cdde46c9c401a19a
ToppCell	cellseq-Mesenchymal-Chondrocytic-Mesenchymal_Airway/Vascular\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	TTYH1 DPT SSTR2	5.76e-04	182	40	3	bb7de0c93d8f59f13c990e425139b9348ca8027e
ToppCell	Smart-seq2-spleen_(Smart-seq2)-lymphocytic-T_lymphocytic-type_I_NK_T_cell\|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	CYSLTR2 GPR171 PTCH1	5.76e-04	182	40	3	9d727ab84da8de33f1021b492c90d8b4c2a8ea23
ToppCell	cellseq-Mesenchymal-Chondrocytic-Mesenchymal_Airway/Vascular-Chondrocyte\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	TTYH1 DPT SSTR2	5.76e-04	182	40	3	507f095af4dff60f2c2b64d750477154084c3595
ToppCell	cellseq-Mesenchymal-Chondrocytic\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	TTYH1 DPT SSTR2	5.76e-04	182	40	3	88bd17c07bd8443a0ede4e9dc7bc9d1230b42211
ToppCell	remission-B_naive\|World / disease stage, cell group and cell class	P2RY14 GGA2 SMIM14	5.76e-04	182	40	3	cc1dfd2de35aee1a26f7efd78e108b60a3556ec5
ToppCell	facs-BAT-Fat-18m-Lymphocytic-B_cell\|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPR171 GGA2 SMIM14	5.95e-04	184	40	3	fd72663bf990266da2fba70d4f2260f8d48067ee
ToppCell	wk_15-18-Epithelial-Proximal_epithelial-intermediate_neuroendocrine\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	HTR1E SSTR2 SLC18A1	5.95e-04	184	40	3	9e5f98f9113e5e38bdadba6d9d2c346177fb35fe
ToppCell	droplet-Spleen-nan-24m-Lymphocytic-B_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPR171 GGA2 SMIM14	5.95e-04	184	40	3	a740ceffa62175578e6cff62da1f8dfaf40098e5
ToppCell	BAL-Control-Myeloid-cDC-cDC-cDC_2\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	P2RY14 ATP8B4 SLC18A1	5.95e-04	184	40	3	0a26bcc6610f756939e32a4d6dfeebcbf3a1db86
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_D_(IT_RORB_THEMIS_LINC00507)_6\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NPFFR2 HTR1E SSTR2	5.95e-04	184	40	3	ca35a3d2b536c8b2bf5c4d635605e5a3ae94a428
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_D_(IT_RORB_THEMIS_LINC00507)_6-Exc_L6_THEMIS_EGR3\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NPFFR2 HTR1E SSTR2	5.95e-04	184	40	3	219bd3b8daa0a713fb6a8a5e1bb35cdb85bb7727
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Epithelial-Bergmann_glial_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTCH2 TTYH1 SSTR2	5.95e-04	184	40	3	f6148e9591e8845cc62668e49fd52755257cdc7e
ToppCell	droplet-Lung-nan-18m-Lymphocytic-B_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPR171 GGA2 SMIM14	6.04e-04	185	40	3	d4076294571557c223f5b68244e9c53e1d8f0343
ToppCell	IIF-Lymphocyte-B-B_naive\|IIF / Disease, Lineage and Cell Type	P2RY14 GGA2 SMIM14	6.04e-04	185	40	3	dec48908addfc71f32f5ce0ce73f2926e476f60b
ToppCell	saliva-Severe-critical_progression_d28-40-Myeloid-Macrophage-macrophage,_alveolar-Macro_c2-CCL3L1\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	PKHD1 P2RY14 BTN2A2	6.04e-04	185	40	3	f30fb9d75cdb757b206312992aaf7485bc900f96
ToppCell	BAL-Control-Myeloid-cDC-cDC-cDC_2\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	P2RY14 ATP8B4 SLC18A1	6.04e-04	185	40	3	fec16a5e527fdef32d25957451b6e8ee9796cafd
ToppCell	BLOOD--(2)_Naive_B_cells\| / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	P2RY14 GGA2 SMIM14	6.14e-04	186	40	3	2e55a3892459152fc4a3a7834ccbf5d71b65d29a
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Immune-Myeloid-Monocytic-Monocyte-derived_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	P2RY14 GPR171 ATP8B4	6.14e-04	186	40	3	e152bdd837366e3e0b8bcfdb4d53f0685f2e803a
Disease	Bartter disease type 3 (implicated_via_orthology)	CLCNKA CLCNKB	1.61e-06	2	38	2	DOID:0110144 (implicated_via_orthology)
Disease	Bartter disease type 4b (is_implicated_in)	CLCNKA CLCNKB	1.61e-06	2	38	2	DOID:0110146 (is_implicated_in)
Disease	Bartter disease type 4B	CLCNKA CLCNKB	1.61e-06	2	38	2	cv:C4310805
Disease	BARTTER SYNDROME, TYPE 4B, NEONATAL, WITH SENSORINEURAL DEAFNESS	CLCNKA CLCNKB	1.61e-06	2	38	2	613090
Disease	Bartter disease (implicated_via_orthology)	CLCNKA CLCNKB	1.61e-06	2	38	2	DOID:445 (implicated_via_orthology)
Disease	BARTTER SYNDROME, TYPE 4B	CLCNKA CLCNKB	1.61e-06	2	38	2	C2751312
Disease	BARTTER SYNDROME, TYPE 4B, NEONATAL, WITH SENSORINEURAL DEAFNESS	CLCNKA CLCNKB	1.61e-06	2	38	2	C4310805
Disease	BASAL CELL CARCINOMA, SUSCEPTIBILITY TO, 1	PTCH2 PTCH1	9.67e-06	4	38	2	605462
Disease	Basal cell carcinoma, susceptibility to, 1	PTCH2 PTCH1	9.67e-06	4	38	2	cv:C2751544
Disease	Oculo-dento-digital syndrome	PTCH2 PTCH1	9.67e-06	4	38	2	C0812437
Disease	Basal Cell Nevus Syndrome	PTCH2 PTCH1	1.61e-05	5	38	2	C0004779
Disease	Choledochal Cyst, Type I	PKHD1 SLC4A2	1.61e-05	5	38	2	C0009439
Disease	Choledochal Cyst	PKHD1 SLC4A2	1.61e-05	5	38	2	C0008340
Disease	Choledochal Cyst, Type II	PKHD1 SLC4A2	1.61e-05	5	38	2	C1257796
Disease	Choledochal Cyst, Type III	PKHD1 SLC4A2	1.61e-05	5	38	2	C1257797
Disease	Choledochal Cyst, Type IV	PKHD1 SLC4A2	1.61e-05	5	38	2	C1257798
Disease	Choledochal Cyst, Type V	PKHD1 SLC4A2	1.61e-05	5	38	2	C1257799
Disease	Bartter syndrome	CLCNKA CLCNKB	2.41e-05	6	38	2	cv:C0004775
Disease	neurodegenerative disease (implicated_via_orthology)	PTCH2 GGA2 PTCH1 DEGS1	3.63e-05	145	38	4	DOID:1289 (implicated_via_orthology)
Disease	Autosomal Recessive Polycystic Kidney Disease	PKHD1 SLC4A2	5.78e-05	9	38	2	C0085548
Disease	nephrogenic diabetes insipidus (implicated_via_orthology)	CLCNKA CLCNKB	7.22e-05	10	38	2	DOID:12387 (implicated_via_orthology)
Disease	autosomal recessive polycystic kidney disease (biomarker_via_orthology)	PKHD1 SLC4A2	8.82e-05	11	38	2	DOID:0110861 (biomarker_via_orthology)
Disease	basal cell carcinoma (is_implicated_in)	PTCH2 PTCH1	1.06e-04	12	38	2	DOID:2513 (is_implicated_in)
Disease	stroke outcome severity measurement	CYSLTR2 TECTA PTCH1	4.29e-04	114	38	3	EFO_0009603
Disease	Pigmented Basal Cell Carcinoma	PTCH2 PTCH1	5.98e-04	28	38	2	C1368275
Disease	Carcinoma, Basal Cell	PTCH2 PTCH1	6.41e-04	29	38	2	C4721806
Disease	sensorineural hearing loss (is_implicated_in)	TECTA CLCNKA	8.31e-04	33	38	2	DOID:10003 (is_implicated_in)
Disease	aspartate aminotransferase measurement	ANO5 SLC66A2 PTCH1 BIRC6 SLC18A1 TMEM236	9.71e-04	904	38	6	EFO_0004736
Disease	Parkinson's disease (implicated_via_orthology)	PTCH2 PTCH1 SSTR2	1.09e-03	157	38	3	DOID:14330 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
WLVIVMTVMSLLVLV	TTYH1	241	Q9H313
MTVMSLLVLVLSWGS	TTYH1	246	Q9H313
VWMMVASLLPAILVF	SLC4A2	991	P04920
VTLWMSLVVTSMVAV	ANO5	466	Q75V66
GVLDIPMISWVVMLV	BIRC6	2161	Q9NR09
PMISWVVMLVSRLLD	BIRC6	2166	Q9NR09
LMILTVWTISIFISM	HTR1E	141	P28566
WSFLILLSVTIPMSM	ATP8B3	431	O60423
TWFTTIVPLVLVITM	ATP8B4	76	Q8TF62
MDLSLLWVLLPLVTM	DPT	1	Q07507
IMIIWVLAITIMSPS	NPFFR2	266	Q9Y5X5
LIPPMDLLEMIVTWI	INTS15	196	Q96N11
TIIIPRMLMDIWTQK	OR10AG1	66	Q8NH19
MHTVTIWLTVRPDMT	RBCK1	66	Q9BYM8
VTLTTMPTVMGILWV	OR51B2	71	Q9Y5P1
TVVWLMVLLIMVPNM	GPR171	136	O14626
TTVWPTMITPMLLTL	MT-ATP8	6	P03928
VLLLTMMSTAPQPVW	GGA2	516	Q9UJY4
DWMVMRLLTSNIIVT	DOCK3	996	Q8IZD9
PNLIWIIIMMVLTQL	DEGS1	41	O15121
ETVPSWMVAVILMAS	IL10RB	216	Q08334
AVILTASPWMVSMTV	BTN2A2	256	Q8WVV5
ASPWMVSMTVILAVF	BTN2A2	261	Q8WVV5
MKVTGITILFWPLSM	LRRC19	1	Q9H756
LVTTIIVPMMLWGLL	OR9A2	71	Q8NGT5
LMLTTWLLPLTIMAS	MT-ND4	66	P03905
MALAMLVLVVSPWSA	MRPL32	1	Q9BYC8
ITMALSWMTIVVPLL	TMEM185A	211	Q8NFB2
PWTAGLIVLVLAMMT	PTCH2	986	Q9Y6C5
WTAGIIVMVLALMTV	PTCH1	1051	Q13635
ISVTMILVAWMVIAL	SMIM14	51	Q96QK8
MTAWLISLMSIEVLL	PKHD1	1	P08F94
LIIVPTSVMLNWEME	SRCAP	671	Q6ZRS2
LSVIVWMLMLLLAVP	P2RY14	141	Q15391
WMLMLLLAVPNIILT	P2RY14	146	Q15391
MITMAVWGVSLLVIL	SSTR2	161	P30874
PTAVMVVLIMVWDGI	TET1	1511	Q8NFU7
LVMKFWMLILATTIP	CLCNKA	406	P51800
LVMKFWMLILATTIP	CLCNKB	406	P51801
IIWILIMASSIMLLD	CYSLTR2	161	Q9NS75
SSMELQVWTLLLIMI	TECTA	2126	O75443
WVTITSPQAIMMSIC	SNX17	361	Q15036
SIISMMKQRTEPWTV	ZNF766	56	Q5HY98
PLLWQSAIMILTMLL	SLC66A2	76	Q8N2U9
WRPVLMMCVVLTTLP	TMEM236	86	Q5W0B7
VAILEPTLPIWMMQT	SLC18A1	316	P54219