Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	structural constituent of skin epidermis	KRT5 KRT6A KRT6B KRT75 KRT6C	1.74e-06	43	94	5	GO:0030280
GeneOntologyBiologicalProcess	intermediate filament organization	KRT5 KRT6A KRT6B KRT75 KRT6C	2.37e-05	75	94	5	GO:0045109
GeneOntologyBiologicalProcess	keratinization	KRT5 KRT6A KRT6B KRT75 KRT6C	4.86e-05	87	94	5	GO:0031424
GeneOntologyBiologicalProcess	positive regulation of activation of membrane attack complex	CR1 C6	6.15e-05	3	94	2	GO:0001970
GeneOntologyBiologicalProcess	intermediate filament cytoskeleton organization	KRT5 KRT6A KRT6B KRT75 KRT6C	9.01e-05	99	94	5	GO:0045104
GeneOntologyBiologicalProcess	intermediate filament-based process	KRT5 KRT6A KRT6B KRT75 KRT6C	9.45e-05	100	94	5	GO:0045103
GeneOntologyBiologicalProcess	regulation of activation of membrane attack complex	CR1 C6	1.23e-04	4	94	2	GO:0001969
GeneOntologyCellularComponent	keratin filament	KRT5 KRT6A KRT6B KRT75 KRT6C	6.93e-05	97	92	5	GO:0045095
Domain	Keratin_2_head	KRT5 KRT6A KRT6B KRT75 KRT6C	1.03e-07	24	92	5	IPR032444
Domain	Keratin_2_head	KRT5 KRT6A KRT6B KRT75 KRT6C	1.03e-07	24	92	5	PF16208
Domain	Keratin_II	KRT5 KRT6A KRT6B KRT75 KRT6C	1.57e-07	26	92	5	IPR003054
Domain	Intermediate_filament_CS	KRT5 KRT6A KRT6B KRT75 KRT6C	1.46e-05	63	92	5	IPR018039
Domain	Filament	KRT5 KRT6A KRT6B KRT75 KRT6C	2.62e-05	71	92	5	SM01391
Domain	IF	KRT5 KRT6A KRT6B KRT75 KRT6C	2.80e-05	72	92	5	PS00226
Domain	Filament	KRT5 KRT6A KRT6B KRT75 KRT6C	3.00e-05	73	92	5	PF00038
Domain	IF	KRT5 KRT6A KRT6B KRT75 KRT6C	3.64e-05	76	92	5	IPR001664
Domain	RII_binding_1	AKAP3 AKAP13	2.38e-04	5	92	2	PF10522
Domain	RII_binding_1	AKAP3 AKAP13	2.38e-04	5	92	2	IPR018459
Domain	VWC	CCN5 FCGBP MUC5AC	8.61e-04	38	92	3	SM00214
Domain	LDLR_class-A_CS	LRP12 MALRD1 C6	1.00e-03	40	92	3	IPR023415
Domain	VWF_dom	CCN5 FCGBP MUC5AC	1.16e-03	42	92	3	IPR001007
Domain	fn3	EPHB4 DSCAM L1CAM FNDC3A TNXB	1.24e-03	162	92	5	PF00041
Domain	Ldl_recept_a	LRP12 MALRD1 C6	1.41e-03	45	92	3	PF00057
Domain	EGF-like_dom	HGFAC DLL4 FCGBP MALRD1 C6 TNXB	1.45e-03	249	92	6	IPR000742
Domain	TIL	FCGBP MUC5AC	1.53e-03	12	92	2	PF01826
Domain	C8	FCGBP MUC5AC	1.53e-03	12	92	2	PF08742
Domain	LDLRA_1	LRP12 MALRD1 C6	1.70e-03	48	92	3	PS01209
Domain	Unchr_dom_Cys-rich	FCGBP MUC5AC	1.81e-03	13	92	2	IPR014853
Domain	C8	FCGBP MUC5AC	1.81e-03	13	92	2	SM00832
Domain	LDLRA_2	LRP12 MALRD1 C6	1.81e-03	49	92	3	PS50068
Domain	LDrepeatLR_classA_rpt	LRP12 MALRD1 C6	1.81e-03	49	92	3	IPR002172
Domain	LDLa	LRP12 MALRD1 C6	1.81e-03	49	92	3	SM00192
Domain	EGF-like_CS	EPHB4 HGFAC DLL4 MALRD1 C6 TNXB	1.84e-03	261	92	6	IPR013032
Domain	EGF_2	EPHB4 HGFAC DLL4 MALRD1 C6 TNXB	1.99e-03	265	92	6	PS01186
Domain	TIL_dom	FCGBP MUC5AC	2.10e-03	14	92	2	IPR002919
Domain	Sushi	CSMD2 CR1 C6	2.15e-03	52	92	3	PF00084
Domain	FN3	EPHB4 DSCAM L1CAM FNDC3A TNXB	2.22e-03	185	92	5	SM00060
Domain	CCP	CSMD2 CR1 C6	2.39e-03	54	92	3	SM00032
Domain	SUSHI	CSMD2 CR1 C6	2.65e-03	56	92	3	PS50923
Domain	VWD	FCGBP MUC5AC	2.75e-03	16	92	2	SM00216
Domain	VWF_type-D	FCGBP MUC5AC	2.75e-03	16	92	2	IPR001846
Domain	VWFD	FCGBP MUC5AC	2.75e-03	16	92	2	PS51233
Domain	VWD	FCGBP MUC5AC	2.75e-03	16	92	2	PF00094
Domain	Sushi_SCR_CCP_dom	CSMD2 CR1 C6	2.79e-03	57	92	3	IPR000436
Domain	FN3	EPHB4 DSCAM L1CAM FNDC3A TNXB	3.04e-03	199	92	5	PS50853
Domain	EGF	HGFAC DLL4 MALRD1 TNXB	3.49e-03	126	92	4	PF00008
Domain	FN3_dom	EPHB4 DSCAM L1CAM FNDC3A TNXB	3.74e-03	209	92	5	IPR003961
Domain	VWC_out	FCGBP MUC5AC	3.89e-03	19	92	2	SM00215
Domain	Znf_RING	RNF223 KAT6A TRIM65 RNF220 MARCHF5 ZNF598	5.48e-03	326	92	6	IPR001841
Domain	TUDOR	SETDB1 TDRD3	5.68e-03	23	92	2	PS50304
Domain	EGF_3	HGFAC DLL4 MALRD1 C6 TNXB	6.12e-03	235	92	5	PS50026
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	VWA5B2 EPHB4 RNF223 FLNA SZT2 L1CAM KAT6A PER1 CEP192 ZDHHC8 CIC ARHGEF10L TDRD3 AATK RPAP1 TULP4 SCN5A AKAP13 WNK2 AHNAK2	3.03e-11	1105	98	20	35748872
Pubmed	Altered keratinocyte differentiation is an early driver of keratin mutation-based palmoplantar keratoderma.	KRT5 KRT6A KRT6B AXIN2 GCLC TNXB	1.90e-08	60	98	6	31220272
Pubmed	Genetic variants in pachyonychia congenita-associated keratins increase susceptibility to tooth decay.	KRT6A KRT6B KRT6C	2.17e-08	3	98	3	29357356
Pubmed	Cytokeratin 5/6 expression in bladder cancer: association with clinicopathologic parameters and prognosis.	KRT5 KRT6A KRT6B	2.17e-08	3	98	3	29587848
Pubmed	Mice expressing a mutant Krt75 (K6hf) allele develop hair and nail defects resembling pachyonychia congenita.	KRT6A KRT6B KRT75	2.17e-08	3	98	3	17851587
Pubmed	Keratin expression provides novel insight into the morphogenesis and function of the companion layer in hair follicles.	KRT6A KRT6B KRT75	2.17e-08	3	98	3	17170733
Pubmed	Cloning and characterization of multiple human genes and cDNAs encoding highly related type II keratin 6 isoforms.	KRT6A KRT6B KRT6C	2.17e-08	3	98	3	7543104
Pubmed	Hague (Hag). A new mouse hair mutation with an unstable semidominant allele.	KRT5 KRT6A KRT6B KRT75	1.05e-07	16	98	4	12399393
Pubmed	Role for keratins 6 and 17 during wound closure in embryonic mouse skin.	KRT5 KRT6A KRT6B	2.16e-07	5	98	3	12557214
Pubmed	The diagnostic utility of D2-40, calretinin, CK5/6, desmin and MOC-31 in the differentiation of mesothelioma from adenocarcinoma in pleural effusion cytology.	KRT5 KRT6A KRT6B	2.16e-07	5	98	3	23075894
Pubmed	Airway hillocks are injury-resistant reservoirs of unique plastic stem cells.	KRT5 KRT6A KRT6B	2.16e-07	5	98	3	38693267
Pubmed	Pachyonychia Congenita	KRT6A KRT6B KRT6C	2.16e-07	5	98	3	20301457
Pubmed	Three epidermal and one simple epithelial type II keratin genes map to human chromosome 12.	KRT5 KRT6A KRT6B	2.16e-07	5	98	3	1713141
Pubmed	Adenomatous polyposis coli (APC) is required for normal development of skin and thymus.	KRT5 KRT6A KRT6B AXIN2	2.22e-07	19	98	4	17002498
Pubmed	Identification of 14-3-3sigma mutation causing cutaneous abnormality in repeated-epilation mutant mouse.	KRT5 KRT6A KRT6B	4.31e-07	6	98	3	16239341
Pubmed	Keratin 6 is not essential for mammary gland development.	KRT5 KRT6A KRT6B	4.31e-07	6	98	3	16790075
Pubmed	p63(+)Krt5(+) distal airway stem cells are essential for lung regeneration.	KRT5 KRT6A KRT6B	4.31e-07	6	98	3	25383540
Pubmed	Genetic elimination of Suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway.	KRT5 KRT6A KRT6B AXIN2	5.04e-07	23	98	4	16459298
Pubmed	RNF208, an estrogen-inducible E3 ligase, targets soluble Vimentin to suppress metastasis in triple-negative breast cancers.	KRT5 KRT6A KRT6B KRT75 KRT6C	5.97e-07	57	98	5	31862882
Pubmed	Prediction of local recurrence, distant metastases, and death after breast-conserving therapy in early-stage invasive breast cancer using a five-biomarker panel.	KRT5 KRT6A KRT6B	7.53e-07	7	98	3	19720911
Pubmed	New consensus nomenclature for mammalian keratins.	KRT5 KRT6A KRT6B KRT75 KRT6C	9.89e-07	63	98	5	16831889
Pubmed	Type II keratins precede type I keratins during early embryonic development.	KRT5 KRT6A KRT6B	1.80e-06	9	98	3	16180309
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	MAP1A TSC22D2 CIC AATK TULP4 UBQLN3 AKAP13 WNK2 MRTFA	3.70e-06	430	98	9	35044719
Pubmed	Defining BMP functions in the hair follicle by conditional ablation of BMP receptor IA.	KRT5 KRT6A KRT6B	4.69e-06	12	98	3	14610062
Pubmed	Breast carcinoma with brain metastases: clinical analysis and immunoprofile on tissue microarrays.	KRT5 KRT75	7.86e-06	2	98	2	21427063
Pubmed	Expression of MK6a dominant-negative and C-terminal mutant transgenes in mice has distinct phenotypic consequences in the epidermis and hair follicle.	KRT6A KRT6B	7.86e-06	2	98	2	10550543
Pubmed	The mouse keratin 6 isoforms are differentially expressed in the hair follicle, footpad, tongue and activated epidermis.	KRT6A KRT6B	7.86e-06	2	98	2	10550545
Pubmed	The two functional keratin 6 genes of mouse are differentially regulated and evolved independently from their human orthologs.	KRT6A KRT6B	7.86e-06	2	98	2	9790766
Pubmed	CIC-NUTM1 Sarcomas Affecting the Spine.	CIC NUTM1	7.86e-06	2	98	2	34525172
Pubmed	Discovery of a novel murine keratin 6 (K6) isoform explains the absence of hair and nail defects in mice deficient for K6a and K6b.	KRT6A KRT6B	7.86e-06	2	98	2	11489919
Pubmed	Introducing a null mutation in the mouse K6alpha and K6beta genes reveals their essential structural role in the oral mucosa.	KRT6A KRT6B	7.86e-06	2	98	2	10953016
Pubmed	The complete cDNA and deduced amino acid sequence of a type II mouse epidermal keratin of 60,000 Da: analysis of sequence differences between type I and type II keratins.	KRT6A KRT6B	7.86e-06	2	98	2	6207530
Pubmed	A reporter transgene based on a human keratin 6 gene promoter is specifically expressed in the periderm of mouse embryos.	KRT6A KRT6B	7.86e-06	2	98	2	11118885
Pubmed	Cytokeratin 5/6 expression in pT1 bladder cancer predicts intravesical recurrence in patients treated with bacillus Calmette-Guérin instillation.	KRT5 KRT6A	7.86e-06	2	98	2	35527047
Pubmed	CIC-NUTM1 fusion: A case which expands the spectrum of NUT-rearranged epithelioid malignancies.	CIC NUTM1	7.86e-06	2	98	2	29700887
Pubmed	Collapse of the keratin filament network through the expression of mutant keratin 6c observed in a case of focal plantar keratoderma.	KRT6A KRT6C	7.86e-06	2	98	2	23662636
Pubmed	Clinicopathologic Features of CIC-NUTM1 Sarcomas, a New Molecular Variant of the Family of CIC-Fused Sarcomas.	CIC NUTM1	7.86e-06	2	98	2	30407212
Pubmed	Delayed wound healing in keratin 6a knockout mice.	KRT6A KRT6B	7.86e-06	2	98	2	10866680
Pubmed	Cytokeratins mediate epithelial innate defense through their antimicrobial properties.	KRT6A KRT6B	7.86e-06	2	98	2	23006328
Pubmed	Vascular endothelial growth factor-A inhibits EphB4 and stimulates delta-like ligand 4 expression in adult endothelial cells.	EPHB4 DLL4	7.86e-06	2	98	2	23394931
Pubmed	Comprehensive Gene Expression Analyses of Immunohistochemically Defined Subgroups of Muscle-Invasive Urinary Bladder Urothelial Carcinoma.	KRT5 KRT6A	7.86e-06	2	98	2	33435173
Pubmed	The role of cytokeratin 5/6 as an adjunct diagnostic tool in breast core needle biopsies.	KRT5 KRT75	7.86e-06	2	98	2	18499686
Pubmed	A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies.	KRT5 KRT6A KRT6B TRIM65 CTTNBP2NL RPAP1 KRT75	1.65e-05	284	98	7	29459677
Pubmed	ACAA2 is a ligand-dependent coactivator for thyroid hormone receptor β1.	KRT5 KRT6A KRT6B PRDM11 KRT75	1.77e-05	113	98	5	34474245
Pubmed	The Wnt/beta-catenin pathway modulates vascular remodeling and specification by upregulating Dll4/Notch signaling.	EPHB4 DLL4 AXIN2	2.03e-05	19	98	3	20627076
Pubmed	The hippo pathway effector Yap controls patterning and differentiation of airway epithelial progenitors.	KRT5 AXIN2 MUC5AC	2.03e-05	19	98	3	25043473
Pubmed	Basal cytokeratin expression in relation to immunohistochemical and clinical characterization in breast cancer patients with triple negative phenotype.	KRT5 KRT75	2.35e-05	3	98	2	19366057
Pubmed	Making a connection: direct binding between keratin intermediate filaments and desmosomal proteins.	KRT5 KRT6A	2.35e-05	3	98	2	7525601
Pubmed	Overcoming functional redundancy to elicit pachyonychia congenita-like nail lesions in transgenic mice.	KRT6A KRT6B	2.35e-05	3	98	2	15601842
Pubmed	LMO7 mediates cell-specific activation of the Rho-myocardin-related transcription factor-serum response factor pathway and plays an important role in breast cancer cell migration.	LMO7 MRTFA	2.35e-05	3	98	2	21670154
Pubmed	Filamin A interacts with the coactivator MKL1 to promote the activity of the transcription factor SRF and cell migration.	FLNA MRTFA	2.35e-05	3	98	2	26554816
Pubmed	A small deletion hotspot in the type II keratin gene mK6irs1/Krt2-6g on mouse chromosome 15, a candidate for causing the wavy hair of the caracul (Ca) mutation.	KRT6A KRT6B	2.35e-05	3	98	2	14573483
Pubmed	Cytokeratin 5/6, c-Met expressions, and PTEN loss prognostic indicators in triple-negative breast cancer.	KRT5 KRT6A	2.35e-05	3	98	2	24326984
Pubmed	Identification of the cancer/testis antigens AKAP3 and CTp11 by SEREX in hepatocellular carcinoma.	AKAP3 UBQLN3	2.35e-05	3	98	2	22941507
Pubmed	Use of immunohistochemical markers can refine prognosis in triple negative breast cancer.	KRT5 KRT6A	2.35e-05	3	98	2	17650314
Pubmed	A role for keratins in supporting mitochondrial organization and function in skin keratinocytes.	KRT6A KRT6B	2.35e-05	3	98	2	32213122
Pubmed	Cytokeratin 5/6 fingerprinting in HER2-positive tumors identifies a poor prognosis and trastuzumab-resistant basal-HER2 subtype of breast cancer.	KRT5 KRT75	2.35e-05	3	98	2	25742793
Pubmed	Cytokeratin 5/6 and P63 immunophenotype of thyroid lymphoepithelial complexes.	KRT5 KRT75	2.35e-05	3	98	2	27130144
Pubmed	The clinical variability of the MECP2 duplication syndrome: description of two families with duplications excluding L1CAM and FLNA.	FLNA L1CAM	2.35e-05	3	98	2	19018795
Pubmed	Non-Muscle-Invasive Bladder Carcinoma with Respect to Basal Versus Luminal Keratin Expression.	KRT5 KRT6A	2.35e-05	3	98	2	33086575
Pubmed	Combination of Dll4/Notch and Ephrin-B2/EphB4 targeted therapy is highly effective in disrupting tumor angiogenesis.	EPHB4 DLL4	2.35e-05	3	98	2	21092311
Pubmed	Loss of keratin 6 (K6) proteins reveals a function for intermediate filaments during wound repair.	KRT6A KRT6B	2.35e-05	3	98	2	14568992
Pubmed	Identification of a cloned sequence activated during multi-stage carcinogenesis in mouse skin.	KRT6A KRT6B	2.35e-05	3	98	2	1713533
Pubmed	KAT6A, a novel regulator of β-catenin, promotes tumorigenicity and chemoresistance in ovarian cancer by acetylating COP1.	B3GLCT KAT6A TRIM65	2.39e-05	20	98	3	33995658
Pubmed	KCTD1/KCTD15 complexes control ectodermal and neural crest cell functions, and their impairment causes aplasia cutis.	KRT5 KRT6A KRT6B	2.39e-05	20	98	3	38113115
Pubmed	AP-2 factors act in concert with Notch to orchestrate terminal differentiation in skin epidermis.	KRT5 KRT6A KRT6B	2.78e-05	21	98	3	18824566
Pubmed	Transcriptomic analysis of the upper lip and primary palate development in mice.	KRT5 KRT6A KRT6B	4.21e-05	24	98	3	36685938
Pubmed	Hemodynamic force is required for vascular smooth muscle cell recruitment to blood vessels during mouse embryonic development.	EPHB4 DLL4 MRTFA	4.21e-05	24	98	3	30796970
Pubmed	Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.	FLNA CSMD2 TULP4 DROSHA AGER C6 WNK2	4.21e-05	329	98	7	17474147
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	KRT5 MAP1A TACC2 CEP192 CIC SETDB1 TDRD3 LMO7 DROSHA	4.40e-05	588	98	9	38580884
Pubmed	Epithelial Wntless regulates postnatal alveologenesis.	AXIN2 AGER	4.70e-05	4	98	2	34931663
Pubmed	Mouse models in preclinical studies for pachyonychia congenita.	KRT6A KRT6B	4.70e-05	4	98	2	16250208
Pubmed	Phosphorylation of human keratin 8 in vivo at conserved head domain serine 23 and at epidermal growth factor-stimulated tail domain serine 431.	KRT6A KRT6C	4.70e-05	4	98	2	9054461
Pubmed	Cytokeratin 5/6 and cytokeratin 8/18 expression in triple negative breast cancers: clinicopathologic significance in South-Asian population.	KRT5 KRT6A	4.70e-05	4	98	2	29884220
Pubmed	Keratin 6 regulates collective keratinocyte migration by altering cell-cell and cell-matrix adhesion.	KRT6A KRT6B	4.70e-05	4	98	2	30389720
Pubmed	A review of the clinical phenotype of 254 patients with genetically confirmed pachyonychia congenita.	KRT6A KRT6B	4.70e-05	4	98	2	22264670
Pubmed	Nuclear control of lung cancer cells migration, invasion and bioenergetics by eukaryotic translation initiation factor 3F.	FLNA KRT6A KRT6B KRT6C	6.18e-05	75	98	4	31527668
Pubmed	A human MAP kinase interactome.	FLNA KRT5 MAP1A CIC SETDB1 AKAP13 MAPK7 WNK2	7.20e-05	486	98	8	20936779
Pubmed	Stage- and subunit-specific functions of polycomb repressive complex 2 in bladder urothelial formation and regeneration.	KRT5 KRT6A KRT6B	7.52e-05	29	98	3	28049658
Pubmed	Hippo signaling promotes lung epithelial lineage commitment by curbing Fgf10 and β-catenin signaling.	KRT5 AXIN2 AGER	7.52e-05	29	98	3	30651296
Pubmed	Hair follicle stem cells regulate retinoid metabolism to maintain the self-renewal niche for melanocyte stem cells.	KRT6A KRT6B	7.82e-05	5	98	2	31898934
Pubmed	Analysis of clinical characteristics and differential diagnosis of the lung biopsy specimens in 99 adenocarcinoma cases and 111 squamous cell carcinoma cases: utility of an immunohistochemical panel containing CK5/6, CK34βE12, p63, CK7 and TTF-1.	KRT5 KRT75	7.82e-05	5	98	2	25063315
Pubmed	Complement modulation in the retinal pigment epithelium rescues photoreceptor degeneration in a mouse model of Stargardt disease.	ABCA4 CR1	7.82e-05	5	98	2	28348233
Pubmed	Multi-apical polarity of alveolar stem cells and their dynamics during lung development and regeneration.	AXIN2 AGER	7.82e-05	5	98	2	36185377
Pubmed	Remotely Produced and Axon-Derived Netrin-1 Instructs GABAergic Neuron Migration and Dopaminergic Substantia Nigra Development.	DSCAM L1CAM PLXNA2	8.33e-05	30	98	3	32562661
Pubmed	Ets1 blocks terminal differentiation of keratinocytes and induces expression of matrix metalloproteases and innate immune mediators.	KRT5 KRT6A KRT6B	9.21e-05	31	98	3	20930145
Pubmed	Dosage-sensitive requirement for mouse Dll4 in artery development.	EPHB4 DLL4	1.17e-04	6	98	2	15466159
Pubmed	Cutting edge: thymic crosstalk regulates delta-like 4 expression on cortical epithelial cells.	KRT5 DLL4	1.17e-04	6	98	2	19050235
Pubmed	Identification of hemopexin as an anti-inflammatory factor that inhibits synergy of hemoglobin with HMGB1 in sterile and infectious inflammation.	TICAM1 AGER	1.17e-04	6	98	2	22772444
Pubmed	Identification of multipotent mammary stem cells by protein C receptor expression.	KRT5 AXIN2	1.17e-04	6	98	2	25327250
Pubmed	Identification of functional variants for cleft lip with or without cleft palate in or near PAX7, FGFR2, and NOG by targeted sequencing of GWAS loci.	KRT6A KRT6B	1.17e-04	6	98	2	25704602
Pubmed	Epithelial heparan sulfate regulates Sonic Hedgehog signaling in lung development.	KRT5 AXIN2 MUC5AC	1.45e-04	36	98	3	28859094
Pubmed	Comparative gene expression analysis of genital tubercle development reveals a putative appendicular Wnt7 network for the epidermal differentiation.	KRT5 KRT6A KRT6B	1.57e-04	37	98	3	20510229
Pubmed	Semaphorin-6A controls guidance of corticospinal tract axons at multiple choice points.	L1CAM PLXNA2	1.64e-04	7	98	2	19063725
Pubmed	Angiopoietin receptor Tie2 is required for vein specification and maintenance via regulating COUP-TFII.	EPHB4 DLL4	1.64e-04	7	98	2	28005008
Pubmed	Artery and vein size is balanced by Notch and ephrin B2/EphB4 during angiogenesis.	EPHB4 DLL4	1.64e-04	7	98	2	18952909
Pubmed	Deciphering TGF-β3 function in medial edge epithelium specification and fusion during mouse secondary palate development.	KRT6A KRT6B	1.64e-04	7	98	2	25104574
Pubmed	Frizzled6 deficiency disrupts the differentiation process of nail development.	KRT6A KRT6B	1.64e-04	7	98	2	23439395
Pubmed	Faciogenital Dysplasia 5 supports cancer stem cell traits in basal-like breast cancer by enhancing EGFR stability.	FLNA KRT5 KRT6A KRT6B LMO7	2.13e-04	191	98	5	33762435
Pubmed	Identification of trichoplein, a novel keratin filament-binding protein.	KRT5 KRT6A	2.18e-04	8	98	2	15731013
Interaction	PHTF1 interactions	KRT5 KRT6A KRT6B KRT75 KRT6C	3.07e-08	20	95	5	int:PHTF1
Interaction	KRT25 interactions	KRT5 KRT6A KRT6B KRT75 KRT6C	6.07e-07	35	95	5	int:KRT25
Interaction	TOP3B interactions	VWA5B2 EPHB4 RNF223 FLNA SZT2 L1CAM KAT6A PER1 CEP192 ZDHHC8 CIC ARHGEF10L AXIN2 TDRD3 AATK RPAP1 TULP4 SCN5A AKAP13 ZNF598 WNK2 AHNAK2	9.65e-07	1470	95	22	int:TOP3B
Interaction	KRT84 interactions	KRT5 KRT6A KRT6B KRT75 KRT6C	3.39e-06	49	95	5	int:KRT84
Interaction	KRT12 interactions	KRT5 KRT6A KRT6B KRT75	4.58e-06	24	95	4	int:KRT12
Interaction	KRT28 interactions	KRT5 KRT6A KRT6B KRT6C	1.16e-05	30	95	4	int:KRT28
Interaction	KRT20 interactions	KRT5 KRT6A KRT6B KRT75 KRT6C	1.19e-05	63	95	5	int:KRT20
Interaction	KRT26 interactions	KRT6A KRT6B KRT75 KRT6C	2.17e-05	35	95	4	int:KRT26
Interaction	DCTN1 interactions	KRT5 KRT6A KRT6B MAP1A DCTN5 ZNF512B TDRD3 AATK KRT75 KRT6C ZNF598	2.22e-05	497	95	11	int:DCTN1
Interaction	KRT36 interactions	KRT5 KRT6A KRT6B KRT75 KRT6C	2.61e-05	74	95	5	int:KRT36
Interaction	RNF208 interactions	KRT5 KRT6A KRT6B KRT75 KRT6C	2.78e-05	75	95	5	int:RNF208
Interaction	KRT7 interactions	KRT5 KRT6A KRT6B KRT75 KRT6C	3.81e-05	80	95	5	int:KRT7
Interaction	EIF3F interactions	FLNA KRT6A KRT6B KAT6A FNDC3A CIC KRT6C ZNF598	7.92e-05	296	95	8	int:EIF3F
Interaction	KRT24 interactions	KRT5 KRT6B KRT75 KRT6C	1.22e-04	54	95	4	int:KRT24
Interaction	EFNA1 interactions	EPHB4 KRT5 KRT6A KRT6B KRT6C	1.27e-04	103	95	5	int:EFNA1
Cytoband	12q13.13	KRT5 KRT6A KRT6B KRT6C	1.35e-05	67	98	4	12q13.13
Cytoband	Ensembl 112 genes in cytogenetic band chr15q15	MAP1A DLL4 RPAP1 STRCP1	2.89e-04	147	98	4	chr15q15
Cytoband	Ensembl 112 genes in cytogenetic band chr7q36	BLACE ATG9B SLC4A2 RNF32-DT	3.89e-04	159	98	4	chr7q36
Cytoband	15q15.3	MAP1A STRCP1	1.31e-03	25	98	2	15q15.3
Cytoband	Ensembl 112 genes in cytogenetic band chr12q13	KRT5 KRT6A KRT6B KRT75 KRT6C	2.18e-03	423	98	5	chr12q13
GeneFamily	Keratins, type II	KRT5 KRT6A KRT6B KRT75 KRT6C	3.06e-08	27	62	5	609
GeneFamily	Fibronectin type III domain containing	EPHB4 DSCAM L1CAM FNDC3A TNXB	2.20e-04	160	62	5	555
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	CSMD2 CR1 C6	9.85e-04	57	62	3	1179
GeneFamily	Beta 3-glycosyltransferases	B3GLCT B3GNT6	3.04e-03	24	62	2	426
Coexpression	JI_CARCINOGENESIS_BY_KRAS_AND_STK11_UP	KRT5 KRT6A KRT6B	1.37e-05	13	97	3	MM743
Coexpression	GU_PDEF_TARGETS_DN	KRT6A KRT6B KRT75 KRT6C	1.45e-05	40	97	4	M10480
ToppCell	AT1\|World / shred by cell class for parenchyma	KRT5 KRT6A KRT6B MS4A15 AATK LMO7 AGER	2.65e-07	196	98	7	2bc487f8a109a6961ebff111dec79c2227ea60ac
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Astrocytoma\|TCGA-Brain / Sample_Type by Project: Shred V9	SZT2 BSDC1 TMEM119 ARHGEF10L ZSWIM9 AKAP13	1.59e-06	162	98	6	810881210e015c788814e4fe8d7a24c929cf2621
ToppCell	nucseq-Epithelial-Epithelial_Glandular\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	KRT6B B3GNT6 FCGBP MUC5AC WNK2 AHNAK2	2.83e-06	179	98	6	859cd8ee414ad6207c046ada2e655e49322dd01c
ToppCell	nucseq-Epithelial-Epithelial_Glandular-Goblet\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	KRT6B B3GNT6 FCGBP MUC5AC WNK2 AHNAK2	2.93e-06	180	98	6	3dc80bc636bf0e6ffc9762853132a9fe59fd1f66
ToppCell	nucseq-Epithelial-Epithelial_Glandular-Goblet-Goblet\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	KRT6B B3GNT6 FCGBP MUC5AC WNK2 AHNAK2	2.93e-06	180	98	6	668a2d8e1d5a390309d5eb62c836f5903144bea9
ToppCell	renal_cortex_nuclei-Adult_normal_reference\|renal_cortex_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group	PER1 FNDC3A TACC2 LMO7 AKAP13 PLXNA2	3.88e-06	189	98	6	a48df46274d51e84ffb40264646de7346104efb9
ToppCell	Parenchymal-10x3prime_v2-Epithelial-Epi_airway_secretory-Secretory_Club\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	KRT5 MS4A15 FCGBP LMO7 MUC5AC WNK2	4.64e-06	195	98	6	b9e8f405f6d837bb39b615836d3e2df349737c0e
ToppCell	Parenchymal-10x3prime_v2-Epithelial-Epi_airway_secretory\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	KRT5 MS4A15 FCGBP LMO7 MUC5AC WNK2	5.21e-06	199	98	6	a8bfc0b93ad9968cf52a25be86995ffe436bd636
ToppCell	Biopsy_Other_PF-Epithelial-AT1\|Biopsy_Other_PF / Sample group, Lineage and Cell type	TACC2 MS4A15 AATK GUCA2A LMO7 AGER	5.36e-06	200	98	6	b746dcc94814bcbca63c71e6451a9c5f084bcfaf
ToppCell	E18.5-samps-Epithelial-Alveolar_epithelial-Uncommitted_AE_Progenitor\|E18.5-samps / Age Group, Lineage, Cell class and subclass	PARG TACC2 NUTM1 LMO7 AGER	7.80e-06	123	98	5	5f002f5180fe47fe57ab888b5f0319df99ab2c59
ToppCell	facs-Marrow-T-cells-24m-Myeloid-monocyte_+_promonocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNA KRT6A KRT6B ARHGEF10L SMPDL3B	2.17e-05	152	98	5	d279592c501fca9cb474ad916fea32282e6969cb
ToppCell	facs-Marrow-T-cells-24m-Myeloid-promonocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNA KRT6A KRT6B ARHGEF10L SMPDL3B	2.17e-05	152	98	5	3b59143b2b4ee24eb6378f87ff568124193256e9
ToppCell	TCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Mucinous_Colon_Adenocarcinoma-5\|TCGA-Colorectal / Sample_Type by Project: Shred V9	MIA3 ABCA4 B3GNT6 FCGBP MUC5AC	2.54e-05	157	98	5	5fb41af247465aa29aa7b8edd26e3d3794766f80
ToppCell	368C-Endothelial_cells-Endothelial-F_(Lymphatics)\|368C / Donor, Lineage, Cell class and subclass (all cells)	EPHB4 ABCA4 DLL4 GUCA2A WNK2	3.51e-05	168	98	5	a74c8a9e3299183fba31ce3053ef325b5dbcd104
ToppCell	368C-Endothelial_cells-Endothelial-F_(Lymphatics)-\|368C / Donor, Lineage, Cell class and subclass (all cells)	EPHB4 ABCA4 DLL4 GUCA2A WNK2	3.51e-05	168	98	5	dae37b316ce80dfe4236c4ed7f0d4e7c340fa7b6
ToppCell	control-Myeloid-pDC\|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	KRT5 MAP1A SZT2 AKAP3 PRMT7	3.51e-05	168	98	5	affc39c7568b7df4b36af6f5b0e3702a18b6268c
ToppCell	TCGA-Bladder-Primary_Tumor-Urothelial_Carcinoma-Non-Papillary_Muscle_Invasive_Urothelial_Carcinoma-6\|TCGA-Bladder / Sample_Type by Project: Shred V9	KRT5 KRT6A KRT6B KRT6C AHNAK2	3.82e-05	171	98	5	0e78389f8f3d54570a6deb3dd307b865b46307e9
ToppCell	TCGA-Head_and_Esophagus\|World / Sample_Type by Project: Shred V9	KRT5 KRT6A KRT6B KRT75 KRT6C	3.93e-05	172	98	5	eb18aa179db1818f408c38e442ecfed8582d7dbc
ToppCell	wk_15-18-Epithelial-Distal_epithelial-type_I_pneumocyte\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	RNF223 AATK GUCA2A LMO7 AGER	4.15e-05	174	98	5	2cd6638b361ca05ab83d09ce657194aed97873b7
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	HGFAC KRT5 KRT6A GCLC ZNF598	4.15e-05	174	98	5	207aa0118633cbe9a65839bbb1bb3ba9f8118ad2
ToppCell	wk_15-18-Epithelial-Proximal_epithelial-SMG_basal_1\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	KRT6A KRT6B FCGBP KRT6C WNK2	4.15e-05	174	98	5	aceca0a22bb1e380835e792681cfc9b752fb5496
ToppCell	368C-Epithelial_cells-Epithelial-B_(AT2)-\|368C / Donor, Lineage, Cell class and subclass (all cells)	KRT6A TACC2 SMPDL3B LMO7 AGER	4.50e-05	177	98	5	ac8f774596068e66c0a9ea8a318be0ce5f5df834
ToppCell	368C-Epithelial_cells-Epithelial-B_(AT2)\|368C / Donor, Lineage, Cell class and subclass (all cells)	KRT6A TACC2 SMPDL3B LMO7 AGER	4.50e-05	177	98	5	d9c4a93b0e04a13bf39992dd1c1ec8df2c5f89fe
ToppCell	3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.2.3\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	AATK SMPDL3B GUCA2A LMO7 AGER	4.62e-05	178	98	5	f3b5eeca6081d65d48824b5d13e3b8eb5fdeb2dd
ToppCell	3'-Pediatric_IBD-SmallIntestine-Epithelial-Tuft-related-BEST4+_epithelial\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	AXIN2 BMP3 MALRD1 GUCA2A WNK2	4.87e-05	180	98	5	7c7c4d64ff99d0710a7d19d8bc29fc9217394db1
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-DN4_thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DSCAM TSC22D2 CTTNBP2NL RPAP1 GCLC	4.87e-05	180	98	5	be10fe5bf7c3a671c42704ce7dd8226ab6896794
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-DN4_thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DSCAM TSC22D2 CTTNBP2NL RPAP1 GCLC	4.87e-05	180	98	5	3b747a517ce75ef2ff09011c037dad7b01ed3e03
ToppCell	ASK454-Epithelial\|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq	TACC2 MS4A15 LMO7 AGER C6	5.13e-05	182	98	5	ab15316cff989b61ff397a866d7ca8b49c13e981
ToppCell	droplet-Large_Intestine-COLON:P+D-30m-Epithelial-large_intestine_goblet_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HGFAC MIA3 DLL4 B3GNT6 FCGBP	5.27e-05	183	98	5	ee9c88be88221b7ad4ea9f890b17d6156fb3432e
ToppCell	droplet-Large_Intestine-COLON:P+D-30m-Epithelial-Goblet_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HGFAC MIA3 DLL4 B3GNT6 FCGBP	5.27e-05	183	98	5	c52b84034503d931f7b87312d2ff86daff14152d
ToppCell	TCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Squamous_Cell_Carcinoma-3\|TCGA-Lung / Sample_Type by Project: Shred V9	KRT5 KRT6A KRT6B LRP12 WNK2	5.41e-05	184	98	5	ea4ccebe2d54279fcc517e4f0bfa652b91a808bb
ToppCell	343B-Epithelial_cells-Epithelial-I_(AT1)\|343B / Donor, Lineage, Cell class and subclass (all cells)	DSCAM MS4A15 AATK LMO7 AGER	5.41e-05	184	98	5	cb15d6bae52c5ec251c2235859dc7e65f630ae23
ToppCell	343B-Epithelial_cells-Epithelial-I_(AT1)-\|343B / Donor, Lineage, Cell class and subclass (all cells)	DSCAM MS4A15 AATK LMO7 AGER	5.41e-05	184	98	5	bde4eaabd3e9bdaed23867d23a919b9d84b52d4b
ToppCell	343B-Fibroblasts-Fibroblast-E-\|343B / Donor, Lineage, Cell class and subclass (all cells)	CEP192 AXIN2 CCN5 TNXB AHNAK2	5.69e-05	186	98	5	1bac7825c2fe3e6cdff65026b09b9ccaa40fa27f
ToppCell	343B-Fibroblasts-Fibroblast-E\|343B / Donor, Lineage, Cell class and subclass (all cells)	CEP192 AXIN2 CCN5 TNXB AHNAK2	5.69e-05	186	98	5	59db239f1864a5d4f1570c93219dbd7ac5b6db35
ToppCell	5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(nasal)-Club_(nasal)_L.0.2.3.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	KRT5 KRT6A KRT6B KRT6C AHNAK2	5.84e-05	187	98	5	a6a112689d1c9049f57935ad9d2f4955538427de
ToppCell	kidney_cells-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MAP1A TMEM119 CCN5 TNXB AHNAK2	5.99e-05	188	98	5	c32d023a69b6da79687ff8fa7485e7499db57046
ToppCell	wk_08-11-Epithelial-Proximal_epithelial-Proximal_secretory_2\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	KRT6A KRT6B FCGBP KRT6C WNK2	5.99e-05	188	98	5	07705bed928683470a52c8ccfa40ffb9a0971318
ToppCell	kidney_cells-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MAP1A TMEM119 CCN5 TNXB AHNAK2	5.99e-05	188	98	5	1cd5a4d744bd3777246958ea5eb94388a5cbad81
ToppCell	facs-MAT-Fat-18m-Endothelial\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPHB4 DLL4 GUCA2A LMO7 PLXNA2	6.30e-05	190	98	5	34e56c5e7ea6a8f227dbaefe73cbb8818d18b523
ToppCell	facs-MAT-Fat-18m-Endothelial-nan\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPHB4 DLL4 GUCA2A LMO7 PLXNA2	6.30e-05	190	98	5	14cdb660ad3aabcf49572173e7628d8b99dcbe6f
ToppCell	TCGA-Skin-Primary_Tumor-Melanoma-Skin_Cutaneous_Melanoma\|TCGA-Skin / Sample_Type by Project: Shred V9	KRT5 KRT6A KRT6B KRT75 KRT6C	6.30e-05	190	98	5	3188c7bd225cbcf46a21e2fb784336cdd9665995
ToppCell	TCGA-Skin-Primary_Tumor\|TCGA-Skin / Sample_Type by Project: Shred V9	KRT5 KRT6A KRT6B KRT75 KRT6C	6.30e-05	190	98	5	e2b26a03c6ab24d9b0f4150c47597be37767d86e
ToppCell	facs-Tongue-nan-3m-Epithelial-suprabasal\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KRT6A KRT6B ARHGEF10L NEU2 AKAP13	6.30e-05	190	98	5	719a5cecc3e8001ca9c38165258b5ff9c800713a
ToppCell	TCGA-Skin-Primary_Tumor-Melanoma\|TCGA-Skin / Sample_Type by Project: Shred V9	KRT5 KRT6A KRT6B KRT75 KRT6C	6.30e-05	190	98	5	01fb45add4661bc86cd0a34fac35177907152dbb
ToppCell	facs-MAT-Fat-18m-Endothelial-endothelial_cell\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPHB4 DLL4 GUCA2A LMO7 PLXNA2	6.30e-05	190	98	5	9aaa48f3aad813c87a45efdbb67d255c94f6e6a4
ToppCell	RV-06._Ventricular_Cardiomyocyte_II\|RV / Chamber and Cluster_Paper	TACC2 LMO7 SCN5A AKAP13 WNK2	6.30e-05	190	98	5	fe8e78922c8ae928ef9a80bffd67868d5a87a091
ToppCell	(7)_Epithelial-G_(Club-Clara_cells)\|World / Lung cell shreds - cell class (v4) and cell subclass (v4)	MS4A15 FCGBP LMO7 MUC5AC WNK2	6.30e-05	190	98	5	593fd1451038b155826a48de4caa38f44406d0b9
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	TACC2 MALRD1 SMPDL3B LMO7 AKAP13	6.61e-05	192	98	5	29f49f00770c991b5f27e4cb701dd2d2d6cb7178
ToppCell	facs-Lung-EPCAM-18m\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNA PARP3 TMEM119 CCN5 BMP3	6.78e-05	193	98	5	b9ac74357435f2f24aaede62b2a1d31b5d96a12c
ToppCell	Parenchymal-10x5prime-Epithelial-Epi_alveolar-Dividing_AT2\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	TACC2 AXIN2 SMPDL3B LMO7 AGER	6.78e-05	193	98	5	44839a606ae2f8e37421bda46d588189e1c943d2
ToppCell	NS-critical-d_07-13-Epithelial-Squamous\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	RNF223 KRT6A ATG9B TICAM1 LMO7	6.95e-05	194	98	5	53a34843d529ef395deb27086f71f7049a087bab
ToppCell	NS-critical-d_0-4-Epithelial-Squamous\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	RNF223 KRT5 KRT6A KRT6B LMO7	6.95e-05	194	98	5	614d0c25b56957c70f397abb169fd2a860eb1c06
ToppCell	RA-03._Atrial_Cardiomyocyte\|RA / Chamber and Cluster_Paper	B3GLCT TACC2 LMO7 SCN5A WNK2	6.95e-05	194	98	5	c3535f7cc0076653c72db582047cff053c322397
ToppCell	COVID-19-Heart-CM_2\|Heart / Disease (COVID-19 only), tissue and cell type	TACC2 LMO7 SCN5A AKAP13 WNK2	7.12e-05	195	98	5	75fc81bddb246dca3b437fb60827b1d4fe416405
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	B3GNT6 FCGBP LMO7 MUC5AC WNK2	7.29e-05	196	98	5	c18874f37b90e6afacc562b2082b67ea8a7cb4a4
ToppCell	BAL-Mild-Epithelial-Epithelial-Basal/Club-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	AXIN2 FCGBP LMO7 MUC5AC WNK2	7.29e-05	196	98	5	a4d05d85fbafa869df19bba3881020ea433d81fb
ToppCell	BAL-Mild-Epithelial-Epithelial-Basal/Club-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	AXIN2 FCGBP LMO7 MUC5AC WNK2	7.29e-05	196	98	5	91a3c3091064f1f5a3bdc1dd5883fc24dce8ff05
ToppCell	BAL-Mild-Epithelial-Epithelial-Basal/Club\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	AXIN2 FCGBP LMO7 MUC5AC WNK2	7.29e-05	196	98	5	e819088a74d29e958371aa851ac9c74ec55367b7
ToppCell	BAL-Mild-Epithelial-Epithelial-Basal/Club\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	AXIN2 FCGBP LMO7 MUC5AC WNK2	7.29e-05	196	98	5	e675d661b6494ac3a85ba7ee5bdeaa98b8bbe957
ToppCell	5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	KRT5 KRT6A KRT6B KRT6C AHNAK2	7.47e-05	197	98	5	fb272c9c60ee3d980e528044dc567b4925a23da6
ToppCell	NS-control-d_0-4-Epithelial-Squamous\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	RNF223 KRT6A KRT6B TICAM1 LMO7	7.47e-05	197	98	5	ab965a0ba87efd3329d24a1ec123985f46fc17c0
ToppCell	critical-Epithelial-Squamous\|critical / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	RNF223 KRT6A ATG9B TICAM1 LMO7	7.47e-05	197	98	5	eccc80d6ab79c46b10108de1cff3abeacfc105cd
ToppCell	5'-Airway_Nasal-Epithelial-Airway_epithelium\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	KRT5 KRT6A KRT6B KRT6C AHNAK2	7.47e-05	197	98	5	61c0d78b29dc4ad8a84172cbfcdab03f31351d0e
ToppCell	5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	KRT5 KRT6A KRT6B KRT6C AHNAK2	7.47e-05	197	98	5	dcabea5c50c133c9a4e294e447462d0393174ea7
ToppCell	5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	KRT6A LMO7 GCLC MUC5AC AHNAK2	7.47e-05	197	98	5	5c4cee914baf7cb43e9cb99cc9e3ae823856dc15
ToppCell	Bronchial-10x5prime-Epithelial-Epi_submucosal-gland\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	KRT6B B3GNT6 FCGBP MUC5AC WNK2	7.47e-05	197	98	5	e2c820c4e4a6cd01ceb020473286e3f5d4e3718e
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.2.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	KRT5 KRT6A KRT6B KRT6C AHNAK2	7.47e-05	197	98	5	2430f31d9312338e0ca23bfc6bdb0365340860fd
ToppCell	Bronchus_Control_(B.)\|World / Sample group, Lineage and Cell type	KRT5 KRT6A KRT6B FCGBP MUC5AC	7.47e-05	197	98	5	b6dff2ee108813e18657e2d8cf850e2423f8c8e9
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-CD4/CD8-Reg_T-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	KRT5 KRT6A KRT6B ABCA4 KRT6C	7.47e-05	197	98	5	9ee927d005eb17843e2516c8006eb192c6ad2af8
ToppCell	distal-Epithelial-Basal-1\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	KRT5 KRT6A KRT6B KRT6C GCLC	7.47e-05	197	98	5	75b4292ce2ad7f9c8b6a4781e1cb71f5b18b74e3
ToppCell	Mild_COVID-19-Epithelial-Basal/Club\|Mild_COVID-19 / Disease group,lineage and cell class （2021.01.30）	AXIN2 FCGBP LMO7 MUC5AC WNK2	7.47e-05	197	98	5	4cc5b778e1e2c6c149160fa147c172977c0fa8eb
ToppCell	Biopsy_IPF-Epithelial-AT1\|Biopsy_IPF / Sample group, Lineage and Cell type	MS4A15 AATK GUCA2A LMO7 AGER	7.65e-05	198	98	5	75bdecbe111fededf6082b11de18b84ca308ef6d
ToppCell	cellseq-Epithelial-Epithelial_Airway-Basal/Suprabasal-Suprabasal\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	KRT5 KRT6A GCLC WNK2 AHNAK2	7.65e-05	198	98	5	6e047de63ef59dcb47e4fc06b173b2a02fdcf4c9
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	KRT5 KRT6A KRT6B GCLC AHNAK2	7.65e-05	198	98	5	89ec1e760a193441092571475cc66a3b425f232e
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-CD4/CD8-Reg_T\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	KRT5 KRT6A KRT6B ABCA4 KRT6C	7.65e-05	198	98	5	3371276410dba693c238b383d990b89371b14d8d
ToppCell	Bronchial-10x5prime-Epithelial-Epi_alveolar-AT1\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	MS4A15 AATK SMPDL3B LMO7 AGER	7.65e-05	198	98	5	54228dd9a50616d2022712d162a419ed0327cabd
ToppCell	5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.2.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	KRT5 KRT6A KRT6B KRT6C AHNAK2	7.65e-05	198	98	5	e06d41a7254a09e037ec404be2d8c352d5cbd7f4
ToppCell	3'-GW_trimst-1-SmallIntestine-Epithelial-goblet-Goblet_cell\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	VWA5B2 ABCA4 FCGBP GUCA2A MUC5AC	7.65e-05	198	98	5	f95f38cc747fb3549a791288bf8d0518c049ac96
ToppCell	control-Epithelial-Squamous\|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	RNF223 KRT6A KRT6B TICAM1 LMO7	7.65e-05	198	98	5	6ba669ac1ed275ae309054941b1457e315766faa
ToppCell	saliva-Severe-critical_progression_d12-22_no-steroids-Epithelial-Epithelial,_Airway-squamous_epithelial_cell-Epi-Squamous\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	RNF223 KRT6A ATG9B FCGBP LMO7	7.65e-05	198	98	5	72d91bd0c727ecadc41e023a16c9326158db1b7b
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-Plasma_B\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	KRT5 KRT6A KRT6B SMPDL3B KRT6C	7.65e-05	198	98	5	96236fa22545f6f4ff3aa8dc002963db8a3468ce
ToppCell	saliva-Severe-critical_progression_d12-22_no-steroids-Epithelial-Epithelial,_Airway-squamous_epithelial_cell\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	RNF223 KRT6A ATG9B FCGBP LMO7	7.65e-05	198	98	5	441608034c787e55691558a480dcd07e37419138
ToppCell	3'-GW_trimst-1-SmallIntestine-Epithelial-goblet\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	VWA5B2 ABCA4 FCGBP GUCA2A MUC5AC	7.65e-05	198	98	5	9c5d7852f03468394e726c444cac92a043fc6d0e
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-Plasma_B-Plasma_B-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	KRT5 KRT6A KRT6B SMPDL3B KRT6C	7.65e-05	198	98	5	9e0fdd63069d17430cdc25bf4ffc762afd5e1728
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-Plasma_B-Plasma_B\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	KRT5 KRT6A KRT6B SMPDL3B KRT6C	7.65e-05	198	98	5	7eb521af938c2609a85d27e2aa7d4317ad6e1e44
ToppCell	medial-2-Epithelial-Mucous\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	KRT6B BMP3 FCGBP MUC5AC WNK2	7.83e-05	199	98	5	4737250b7ffa7cc19eb6b057d35d78f13b1afe66
ToppCell	control-Epithelial-Squamous\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	RNF223 KRT6A KRT6B TICAM1 LMO7	7.83e-05	199	98	5	e13dca7a055cdca53dd6c26c04b2a46d58b419b6
ToppCell	medial-2-Epithelial-Alveolar_Epithelial_Type_1\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	TACC2 MS4A15 AATK LMO7 AGER	7.83e-05	199	98	5	456460c761e26ed4b1d88d9bee4d2a7c9bd9d416
ToppCell	Parenchymal-10x5prime-Epithelial-Epi_alveolar-AT1\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	TACC2 MS4A15 AATK LMO7 AGER	7.83e-05	199	98	5	aca81a879ef9c196bd1885eff4c63ffe6c9682b7
ToppCell	Tracheal-10x5prime-Epithelial-Epi_submucosal-gland-SMG_Duct\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	RNF223 KRT6B FCGBP LMO7 WNK2	7.83e-05	199	98	5	ef1a0c278c23614fd6a3218a9733abe6ecd6f686
ToppCell	Tracheal-10x5prime-Epithelial-Epi_submucosal-gland-SMG_Mucous\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	TACC2 B3GNT6 FCGBP LMO7 MUC5AC	7.83e-05	199	98	5	f37114cf849837fdb8ed9a767de773e8681b7df3
ToppCell	Biopsy_Other_PF-Epithelial-MUC5B+\|Biopsy_Other_PF / Sample group, Lineage and Cell type	KRT6B FCGBP LMO7 MUC5AC WNK2	7.83e-05	199	98	5	afd0df242a93f176438309668a9487be1250d9ca
ToppCell	medial-Epithelial-Alveolar_Epithelial_Type_1-2\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	TACC2 MS4A15 AATK LMO7 AGER	7.83e-05	199	98	5	5263338242f95c04690d0795749ccc20b0d19f7a
ToppCell	Bronchial-10x5prime-Epithelial-Epi_airway_secretory-Secretory_Goblet\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	RNF223 KRT6B B3GNT6 MUC5AC WNK2	7.83e-05	199	98	5	ec1e110671e7725f752163c7241dbbf638dec2b2
ToppCell	medial-Epithelial-Mucous\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	KRT6B BMP3 FCGBP MUC5AC WNK2	7.83e-05	199	98	5	4385963ab25b5378e7964b984028c25b27e5794e
ToppCell	saliva-Mild-Moderate_progression_d12-25-Epithelial-Epithelial,_Airway\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	RNF223 ATG9B TICAM1 LMO7 MARCHF5	7.83e-05	199	98	5	245b37df56dfbbdbac88f0e2fc3dfa0ed1abd588
ToppCell	Tracheal-10x5prime-Epithelial-Epi_airway_secretory\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	RNF223 B3GNT6 BMP3 LMO7 MUC5AC	7.83e-05	199	98	5	7223f853335492ca617dbec3e4b6872a8a463a45
ToppCell	medial-Epithelial-Alveolar_Epithelial_Type_1\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	TACC2 MS4A15 AATK LMO7 AGER	7.83e-05	199	98	5	c11365653c69a5dfb37946231f8af05149a61a71
ToppCell	Tracheal-10x5prime-Epithelial-Epi_airway_secretory-Secretory_Goblet\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	RNF223 B3GNT6 BMP3 LMO7 MUC5AC	7.83e-05	199	98	5	e03bdc7cb825e287f41b834ec6061d23c1c03b04
Computational	Genes in the cancer module 68.	KRT5 KRT6A KRT6B	3.55e-04	26	58	3	MODULE_68
Computational	Keratin.	KRT5 KRT6A KRT6B	3.55e-04	26	58	3	MODULE_298
Computational	Intermediate filaments and MT.	KRT5 KRT6A KRT6B TACC2	4.81e-04	68	58	4	MODULE_438
Drug	SC-791	KRT6A KRT6B KRT75 KRT6C	4.42e-09	6	96	4	CID010291510
Drug	Olux	KRT6A KRT6B KRT75 KRT6C GCLC	1.77e-08	20	96	5	CID000032797
Drug	clobestasol propionate	KRT6A KRT6B KRT75 KRT6C	6.77e-07	17	96	4	CID000002791
Drug	dithranol	KRT6A KRT6B KRT75 KRT6C	8.68e-07	18	96	4	CID000002202
Drug	MK-6	KRT6A KRT6B KRT75 KRT6C	2.96e-06	24	96	4	CID005283547
Drug	Bhg-(2-1)fuc	KRT6A KRT6B KRT75 KRT6C	3.51e-06	25	96	4	CID005287784
Drug	betamethasone valerate	KRT6A KRT6B KRT75 KRT6C	5.62e-06	28	96	4	CID000016533
Drug	2-Formyl-Protoporphryn Ix	KRT6A KRT6B KRT75 KRT6C	8.56e-06	31	96	4	CID011963946
Drug	AGN 193109	KRT6A KRT6B KRT75 KRT6C	8.56e-06	31	96	4	CID000177238
Drug	PD153035	EPHB4 KRT6A KRT6B KRT75 KRT6C MAPK7	1.65e-05	127	96	6	CID000004705
Drug	chrysarobin	KRT6A KRT6B KRT75 KRT6C	1.76e-05	37	96	4	CID000068111
Drug	Muramic acid, N-acetyl [10597-89-4]; Up 200; 13.6uM; MCF7; HT_HG-U133A	PARP3 L1CAM KAT6A PER1 CIC SLC4A2 MAPK7	1.78e-05	193	96	7	3262_UP
Drug	sulfur mustard	KRT5 KRT6A KRT6B PARP3 KRT75 KRT6C	1.88e-05	130	96	6	CID000010461
Drug	Oxamniquine [21738-42-1]; Up 200; 14.4uM; MCF7; HT_HG-U133A	MAP1A PER1 AATK MAPK7 MUC5AC MRTFA AHNAK2	1.90e-05	195	96	7	4124_UP
Drug	Phenformin hydrochloride [834-28-6]; Down 200; 16.6uM; MCF7; HT_HG-U133A	EPHB4 LRP12 FNDC3A TSC22D2 TDRD3 AKAP13 MRTFA	1.96e-05	196	96	7	2312_DN
Drug	4-hydroxytestosterone	KRT5 KRT6A KRT6B KRT75 KRT6C	1.99e-05	78	96	5	CID000160615
Drug	Midecamycin [35457-80-8]; Down 200; 5uM; PC3; HG-U133A	DCTN5 TICAM1 FNDC3A TACC2 TSC22D2 RNF220 GCLC	2.10e-05	198	96	7	1943_DN
Drug	CaLam	KRT6A KRT6B KRT75 KRT6C	2.18e-05	39	96	4	CID004126474
Drug	AC1L9LMC	FLNA KRT6A KRT6B KRT75 KRT6C	2.69e-05	83	96	5	CID000448113
Drug	PD 128907	DRD5 GUCA2A MUC5AC	3.19e-05	15	96	3	CID000005117
Drug	benzalkonium	KRT5 KRT6A KRT6B KRT75 KRT6C GCLC	3.90e-05	148	96	6	CID000007681
Drug	sodium dodecyl sulfate	KRT6A KRT6B KRT75 KRT6C OPLAH	4.19e-05	91	96	5	CID000008778
Drug	mant-GTP	KRT6A KRT6B KRT75 KRT6C	5.89e-05	50	96	4	CID000128647
Drug	CD-III	KRT6A KRT6B KRT75 KRT6C	7.42e-05	53	96	4	CID000066693
Drug	N1-acetylspermidine	KRT6A KRT6B KRT6C	7.86e-05	20	96	3	CID000000496
Drug	DIMIT	KRT5 KRT6A KRT6B KRT6C	9.21e-05	56	96	4	CID000006624
Drug	cignolin	KRT6A KRT6B KRT75 KRT6C	9.21e-05	56	96	4	CID000010187
Drug	Withaferin A [5119-48-2]; Down 200; 1uM; PC3; HT_HG-U133A	MAP1A PARP3 PER1 KRT75 MAPK7 PRMT7	1.12e-04	179	96	6	4554_DN
Drug	phorbol 12-myristate	KRT5 KRT6A KRT6B NEU2 KRT75 KRT6C MAPK7	1.20e-04	261	96	7	CID000107854
Drug	AC1L9MJT	KRT5 KRT6A KRT6B KRT75 KRT6C TAF4	1.64e-04	192	96	6	CID000448959
Drug	teleocidin B	KRT5 KRT6A KRT6B KRT75 KRT6C	1.75e-04	123	96	5	CID000072425
Drug	Apramycin [37321-09-8]; Down 200; 7.4uM; PC3; HT_HG-U133A	L1CAM PER1 ZNF512B LMO7 MAPK7 MRTFA	1.79e-04	195	96	6	6614_DN
Drug	chlorpromazine hydrochloride; Up 200; 1uM; MCF7; HT_HG-U133A	LRP12 MAP1A KRT75 C6 MUC5AC PLXNA2	1.84e-04	196	96	6	5577_UP
Drug	Mefenamic acid [61-68-7]; Down 200; 16.6uM; PC3; HT_HG-U133A	EPHB4 KRT6B MAP1A PARP3 SETDB1 SMPDL3B	1.84e-04	196	96	6	1821_DN
Drug	Deptropine citrate [2169-75-7]; Up 200; 7.6uM; HL60; HT_HG-U133A	EPHB4 DSCAM TICAM1 CIC TDRD3 C6	1.84e-04	196	96	6	3144_UP
Drug	PHA-00745360 [351320-33-7]; Up 200; 10uM; MCF7; HT_HG-U133A	KRT6B LRP12 L1CAM TDRD3 C6 MAPK7	1.84e-04	196	96	6	3907_UP
Drug	Oxybenzone [131-57-7]; Down 200; 17.6uM; PC3; HT_HG-U133A	EPHB4 KAT6A ZNF512B LMO7 MAPK7 PRMT7	1.84e-04	196	96	6	6309_DN
Drug	Orphenadrine hydrochloride [341-69-5]; Down 200; 13uM; MCF7; HT_HG-U133A	KRT6B SZT2 KAT6A TDRD3 AKAP13 MRTFA	1.84e-04	196	96	6	4359_DN
Drug	Molindone hydrochloride [15622-65-8]; Up 200; 12.8uM; MCF7; HT_HG-U133A	LRP12 MAP1A DSCAM AKAP13 MAPK7 PLXNA2	1.84e-04	196	96	6	7337_UP
Drug	Clofilium tosylate [92953-10-1]; Up 200; 7.8uM; MCF7; HT_HG-U133A	KAT6A CIC SMPDL3B RPAP1 MUC5AC MRTFA	1.89e-04	197	96	6	6830_UP
Drug	Homosalate [118-56-9]; Down 200; 15.2uM; MCF7; HT_HG-U133A	MIA3 PARP3 KAT6A PER1 FNDC3A RPAP1	1.89e-04	197	96	6	4355_DN
Drug	PNU-0293363 [326823-19-2]; Up 200; 10uM; PC3; HT_HG-U133A	TICAM1 PER1 SLC4A2 SETDB1 KRT75 MUC5AC	1.89e-04	197	96	6	6563_UP
Drug	2-propylpentanoic acid; Down 200; 50uM; PC3; HT_HG-U133A	EPHB4 PER1 ZNF512B SMPDL3B AKAP13 MRTFA	1.89e-04	197	96	6	1222_DN
Drug	Diloxanide furoate [3736-81-0]; Down 200; 12.2uM; MCF7; HT_HG-U133A	TICAM1 PER1 FNDC3A CR1 RPAP1 AHNAK2	1.89e-04	197	96	6	3399_DN
Drug	Dipyrone [5907-38-0]; Down 200; 12uM; PC3; HT_HG-U133A	LRP12 PARP3 KAT6A ARHGEF10L SMPDL3B MRTFA	1.94e-04	198	96	6	3754_DN
Drug	Metaproterenol sulfate, orciprenaline sulfate [5874-97-5]; Up 200; 7.6uM; MCF7; HT_HG-U133A	KRT6B LRP12 SZT2 PER1 MAPK7 AHNAK2	1.94e-04	198	96	6	2845_UP
Drug	Zidovudine, AZT [30516-87-1]; Up 200; 15uM; HL60; HG-U133A	EPHB4 LRP12 CR1 SLC4A2 TULP4 C6	1.94e-04	198	96	6	1595_UP
Drug	Dizocilpine maleate [77086-22-7]; Down 200; 11.8uM; PC3; HT_HG-U133A	EPHB4 KRT6B TSC22D2 ARHGEF10L TDRD3 SMPDL3B	1.94e-04	198	96	6	2069_DN
Drug	alpha-estradiol; Down 200; 0.01uM; MCF7; HT_HG-U133A	LRP12 PER1 BSDC1 TSC22D2 TDRD3 AKAP13	2.00e-04	199	96	6	5207_DN
Drug	Thyroxine (L) [51-48-9]; Up 200; 5.2uM; MCF7; HT_HG-U133A	MIA3 SZT2 PARP3 PER1 TDRD3 MAPK7	2.00e-04	199	96	6	3249_UP
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; HL60; HT_HG-U133A	KAT6A CR1 SETDB1 TDRD3 MAPK7 MRTFA	2.00e-04	199	96	6	2566_DN
Drug	Xylazine [7361-61-7]; Down 200; 18.2uM; HL60; HT_HG-U133A	EPHB4 SZT2 KAT6A BSDC1 TDRD3 AKAP13	2.00e-04	199	96	6	2132_DN
Drug	Vitexin [3681-93-4]; Down 200; 9.2uM; MCF7; HT_HG-U133A	KRT6B LRP12 SZT2 PER1 MAPK7 MRTFA	2.05e-04	200	96	6	4413_DN
Drug	Divonex	KRT6A KRT6B KRT75 KRT6C	2.08e-04	69	96	4	CID000002522
Disease	Pachyonychia congenita syndrome	KRT6A KRT6B	6.13e-05	4	95	2	cv:C0265334
Disease	Pachyonychia Congenita, Jadassohn Lewandowsky Type	KRT6A KRT6B	6.13e-05	4	95	2	C1706595
Disease	pachyonychia congenita (is_implicated_in)	KRT6A KRT6B	6.13e-05	4	95	2	DOID:0050449 (is_implicated_in)
Disease	Pachyonychia Congenita, Type 2 (disorder)	KRT6A KRT6B	6.13e-05	4	95	2	C1721007
Disease	Pachyonychia Congenita	KRT6A KRT6B	1.02e-04	5	95	2	C0265334
Disease	intraocular pressure measurement	LRP12 ABCA4 C10orf55 TMEM119 TSC22D2 LMO7 AKAP13 TNXB	2.43e-04	509	95	8	EFO_0004695
Disease	hemangiopericytoma (is_marker_for)	EPHB4 DLL4	3.64e-04	9	95	2	DOID:264 (is_marker_for)
Disease	Abnormality of refraction	ABCA4 DSCAM TMEM119 TSC22D2 AXIN2 BMP3 AKAP13 C6	1.50e-03	673	95	8	HP_0000539
Disease	transient cerebral ischemia (biomarker_via_orthology)	DLL4 AXIN2 AGER WNK2	1.69e-03	157	95	4	DOID:224 (biomarker_via_orthology)
Disease	cognitive function measurement	DSCAM SZT2 DLL4 PER1 CEP192 TSC22D2 ZBTB45 TULP4 TNXB RNF32-DT WNK2 MRTFA	2.18e-03	1434	95	12	EFO_0008354
Disease	Attention Deficit Disorder	DRD5 CIC	2.27e-03	22	95	2	C0041671
Disease	Minimal Brain Dysfunction	DRD5 CIC	2.27e-03	22	95	2	C1321905
Disease	Attention deficit hyperactivity disorder	DRD5 CIC	2.70e-03	24	95	2	C1263846
Disease	initial pursuit acceleration	ARHGEF10L LMO7 RNF32-DT	2.82e-03	87	95	3	EFO_0008434
Disease	response to venlafaxine	B3GLCT CSMD2	2.93e-03	25	95	2	EFO_0006328

Protein segments in the cluster

Peptide	Gene	Start	Entry
PVENGGCPVGIETPV	CTTNBP2NL	386	Q9P2B4
CTPEPESLGPGTPGF	SLC4A2	16	P04920
VGVVPGIPEPCCVPE	BMP3	426	P12645
ESPPVCLTVGPGPVR	ARHGEF10L	961	Q9HCE6
GPPLTPVPEFCTNDV	B3GLCT	231	Q6Y288
DTPPPVTSPRGDGIC	BLACE	66	A4D250
PTLTTCADPGVPQFG	CSMD2	3126	Q7Z408
CFQSPTPGESPGIVS	ABCA4	81	P78363
ISTFPEGEPGPQSPC	BSDC1	246	Q9NW68
PETDGQFLPCAPEPT	AKAP13	311	Q12802
PGPCTFGTVSTPVLG	DLL4	71	Q9NR61
VPGEEGETPPCQPGV	AXIN2	26	Q9Y2T1
GPGCFPAVAVVVPVP	RNF32-DT	111	Q8NI28
PGGTVTLTCEVPAQP	AGER	251	Q15109
PEGPPAGFPCVSETT	DRD5	326	P21918
AQEGPPLAVPEFPVC	NOBOX	26	O60393
QVVVPQGQPVPCPEF	PARP3	491	Q9Y6F1
FQPSLQPVASEPGCP	MAPK7	401	Q13164
GFPVCPPGGIQEVTV	KRT6C	126	P48668
GLIPPVEDFPVCSPN	LRP12	556	Q9Y561
GTTGGPCPVTDETPP	MAP1A	2486	P78559
VPVVFPGPVSQEGCC	MAD2L1BP	56	Q15013
GSCVVDAVPAPGPSP	EPHB4	221	P54760
GFPVCPPGGIQEVTV	KRT6A	126	P02538
PFQVCPSAGSQPVPD	SMPDL3B	41	Q92485
GFPVCPPGGIQEVTV	KRT5	131	P13647
EGPGPPAPVTFQQIC	PER1	536	O15534
CVSPPSSNGLGPVPV	PLXNA2	1006	O75051
GFPVCPPGGIQEVTV	KRT6B	126	P04259
VQFRVPPSSPACVPG	PARG	46	Q86W56
GCPGFTLPEVKPNPV	GCLC	151	P48506
EIVGTAGPPCPGAPV	POU5F2	276	Q8N7G0
GTTVPPISFTPGPCS	LMO7	651	Q8WWI1
SIFPGIGCPVPRIPA	MARCHF5	181	Q9NX47
GESVVLPCNPPPSAE	L1CAM	151	P32004
PVPEPPRNCSTGFGI	MUC5AC	251	P98088
VLGPPEPPFSHVCQV	PDF	56	Q9HBH1
GEPVVPILCSNPNFP	GUCA2A	61	Q02747
FVQPICLPEPGSTFP	HGFAC	516	Q04756
TPCGGLEGPAPPFVT	NUTM1	121	Q86Y26
EPPPQGCQGSVISFP	NEU2	266	Q9Y3R4
VGVTGPPDPQVRCPS	KAT6A	496	Q92794
PPDPQVRCPSVIEFG	KAT6A	501	Q92794
FTPECVTGGPVPVQP	MALRD1	1886	Q5VYJ5
VTGGPVPVQPSPCEA	MALRD1	1891	Q5VYJ5
EVGPRPQIPATCEPG	LINC00472	46	Q9H8W2
DSGCPQPVPPENGFI	C6	641	P13671
CEQIFCPSPPVIPNG	CR1	416	P17927
CEQIFCPSPPVIPNG	CR1	866	P17927
VPPVDVESCPGAPSV	PRMT7	211	Q9NVM4
PSPCTPEQQESFGGP	FCGBP	4651	Q9Y6R7
PSSPFQVPVTEGCDP	FLNA	1341	P21333
GAGPFSEVVACVTPP	FNDC3A	836	Q9Y2H6
FSGLVSSLPPGVPCP	CCN5	181	O76076
FSPPTAGPPCSVLQG	ATG9B	66	Q674R7
PETVVPPFTVFSGCP	DCTN5	136	Q9BTE1
FVVIPPNNASGLCPP	MS4A15	11	Q8N5U1
PFPVPSVGTNCGIEP	CEP192	1346	Q8TEP8
CQPPSLPEEGSPGAV	C19orf54	271	Q5BKX5
PSELVPGPPCVANAS	B3GNT6	61	Q6ZMB0
SVGRCSVPEGPFPGQ	PCDHB3	721	Q9Y5E6
GTLVPCPAAGIPPVT	DSCAM	41	O60469
PAAPGTVIQTPPFVG	TAF4	231	O00268
EIFGPCSPGQLGPSP	SZT2	2586	Q5T011
SVVPEPAGCTPELPG	DROSHA	321	Q9NRR4
SPGVFPVTVQPPHCV	TMEM248	191	Q9NWD8
GGPPPFVPFGQKCVS	TDRD3	86	Q9H7E2
PCQPTGVPPATVGGV	TSC22D2	451	O75157
GVPPATVGGVVQPCL	TSC22D2	456	O75157
PVSGGECSPPLTVEP	MIA3	1671	Q5JRA6
CAPDGAPPGVVPVLS	AATK	506	Q6ZMQ8
KPPFPADVGVFGCPT	NDUFV1	226	P49821
FPCIFGPGENQPLSP	OPLAH	406	O14841
CPNHGPPVFVSDTPV	PRDM11	121	Q9NQV5
QGTPGDPEPVCVPIA	SCN5A	1036	Q14524
PVPGACFTRVQPTPL	SELENOO	76	Q9BVL4
PCQQPRPFGVPVSVD	RNF220	41	Q5VTB9
PCAVAPGPPSVVVKQ	MRTFA	611	Q969V6
PSIPVGGCNPPSSEE	SETDB1	961	Q15047
GQPPEGCAAPTVIVS	AKAP3	746	O75969
VPVSQPCGEGIAPTP	AHNAK2	5141	Q8IVF2
PPACAAPGGPVITAF	CIC	1081	Q96RK0
GSPGGLFLPCQPVPT	C10orf55	106	Q5SWW7
PLPTTPGREPGFVCV	RNF223	146	E7ERA6
PCGPTSSQNPELVIP	ZNF837	91	Q96EG3
PVTGASGVPENSPPC	TULP4	671	Q9NRJ4
SGVPENSPPCTVNIP	TULP4	676	Q9NRJ4
VVCVPVPVQVGAGPS	ZNF653	276	Q96CK0
GAVPEGCPTETPVQP	ZBTB45	296	Q96K62
VGPPQPGCPAFIIVK	ZSWIM9	91	Q86XI8
ASLVPEPVPGGCQEP	TICAM1	236	Q8IUC6
GCPPGTEPPVLASEV	TNXB	86	P22105
VSTQPPPEEPGCGSE	TACC2	1981	O95359
VGPPEGAVTCETPTP	RPAP1	176	Q9BWH6
FSVTGPAAPGCVGVP	ZNF598	416	Q86UK7
VPGQAPLCFDPGSPA	ZNF512B	51	Q96KM6
PGALQVCSSEPAEPP	VWA5B2	951	Q8N398
FPTGPKVPFCGPGEQ	ZDHHC8	361	Q9ULC8
GPAVCIPGQQPIPTT	STRCP1	1116	A6NGW2
VCSPPVSEGPVLPQS	WNK2	651	Q9Y3S1
VEAPGPLAPVPSTVC	TRIM65	306	Q6PJ69
QEAQGPVGPPESPCA	TMEM119	261	Q4V9L6
ECPAASVPTQGPSPG	UBQLN3	101	Q9H347
PSFPVCPPGGIQEVT	KRT75	111	O95678