Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	KDEL sequence binding	KDELR2 KDELR1	5.48e-05	3	86	2	GO:0005046
GeneOntologyMolecularFunction	ER retention sequence binding	KDELR2 KDELR1	1.82e-04	5	86	2	GO:0046923
GeneOntologyMolecularFunction	sodium:bicarbonate symporter activity	SLC4A7 SLC4A5	2.72e-04	6	86	2	GO:0008510
GeneOntologyMolecularFunction	guanyl-nucleotide exchange factor activity	DENND5B MYCBP2 DOCK7 WDR41 DENND5A DOCK6	4.88e-04	231	86	6	GO:0005085
Domain	Ecm29/Gcn1	ECPAS GCN1	2.14e-05	2	87	2	IPR026827
Domain	DUF4062	NWD2 TEP1	2.14e-05	2	87	2	PF13271
Domain	DUF4062	NWD2 TEP1	2.14e-05	2	87	2	IPR025139
Domain	ER_ret_rcpt	KDELR2 KDELR1	6.42e-05	3	87	2	IPR000133
Domain	ER_lumen_recept	KDELR2 KDELR1	6.42e-05	3	87	2	PF00810
Domain	ER_LUMEN_RECEPTOR_1	KDELR2 KDELR1	6.42e-05	3	87	2	PS00951
Domain	ER_LUMEN_RECEPTOR_2	KDELR2 KDELR1	6.42e-05	3	87	2	PS00952
Domain	DUF846_euk	TVP23C TVP23B	1.28e-04	4	87	2	IPR008564
Domain	DUF846	TVP23C TVP23B	1.28e-04	4	87	2	PF05832
Domain	DUF3398	DOCK7 DOCK6	3.18e-04	6	87	2	PF11878
Domain	DOCK_C/D_N	DOCK7 DOCK6	3.18e-04	6	87	2	IPR021816
Domain	-	ATP8B4 ATP12A ATP9A	4.39e-04	32	87	3	3.40.1110.10
Domain	-	ATP8B4 ATP12A ATP9A	4.39e-04	32	87	3	2.70.150.10
Domain	ANION_EXCHANGER_2	SLC4A7 SLC4A5	4.44e-04	7	87	2	PS00220
Domain	ANION_EXCHANGER_1	SLC4A7 SLC4A5	4.44e-04	7	87	2	PS00219
Domain	ATPase_P-typ_cyto_domN	ATP8B4 ATP12A ATP9A	5.74e-04	35	87	3	IPR023299
Domain	P_typ_ATPase	ATP8B4 ATP12A ATP9A	6.24e-04	36	87	3	IPR001757
Domain	ATPase_P-typ_P_site	ATP8B4 ATP12A ATP9A	6.24e-04	36	87	3	IPR018303
Domain	ATPASE_E1_E2	ATP8B4 ATP12A ATP9A	6.24e-04	36	87	3	PS00154
Domain	ATPase_P-typ_transduc_dom_A	ATP8B4 ATP12A ATP9A	6.76e-04	37	87	3	IPR008250
Domain	E1-E2_ATPase	ATP8B4 ATP12A ATP9A	6.76e-04	37	87	3	PF00122
Domain	Band3_cytoplasmic_dom	SLC4A7 SLC4A5	7.56e-04	9	87	2	IPR013769
Domain	Band_3_cyto	SLC4A7 SLC4A5	7.56e-04	9	87	2	PF07565
Domain	-	SLC4A7 SLC4A5	7.56e-04	9	87	2	3.40.1100.10
Domain	-	SEMA3D NWD2 WDR12 ELP2 WDR41 CFAP43 TEP1	9.27e-04	333	87	7	2.130.10.10
Domain	HCO3_cotransp	SLC4A7 SLC4A5	9.42e-04	10	87	2	PF00955
Domain	HCO3_transpt_C	SLC4A7 SLC4A5	9.42e-04	10	87	2	IPR011531
Domain	PTrfase/Anion_transptr	SLC4A7 SLC4A5	9.42e-04	10	87	2	IPR016152
Domain	HCO3_transpt_euk	SLC4A7 SLC4A5	9.42e-04	10	87	2	IPR003020
Domain	WD40/YVTN_repeat-like_dom	SEMA3D NWD2 WDR12 ELP2 WDR41 CFAP43 TEP1	9.60e-04	335	87	7	IPR015943
Domain	ARM-type_fold	URB1 PIK3CA RRP12 HEATR5A CTNNB1 ECPAS GCN1	1.03e-03	339	87	7	IPR016024
Domain	MBOAT_fam	HHAT PORCN	1.15e-03	11	87	2	IPR004299
Domain	DOCK_C	DOCK7 DOCK6	1.15e-03	11	87	2	IPR010703
Domain	DHR-1_domain	DOCK7 DOCK6	1.15e-03	11	87	2	IPR027007
Domain	DHR_2	DOCK7 DOCK6	1.15e-03	11	87	2	PS51651
Domain	DHR_1	DOCK7 DOCK6	1.15e-03	11	87	2	PS51650
Domain	DOCK-C2	DOCK7 DOCK6	1.15e-03	11	87	2	PF14429
Domain	DHR-2	DOCK7 DOCK6	1.15e-03	11	87	2	IPR027357
Domain	DHR-2	DOCK7 DOCK6	1.15e-03	11	87	2	PF06920
Domain	MRGPCRFAMILY	MRGPRX1 MRGPRX2	1.15e-03	11	87	2	IPR026234
Domain	MBOAT	HHAT PORCN	1.15e-03	11	87	2	PF03062
Domain	DOCK	DOCK7 DOCK6	1.15e-03	11	87	2	IPR026791
Domain	WD40	NWD2 WDR12 ELP2 WDR41 CFAP43 TEP1	1.58e-03	268	87	6	SM00320
Domain	WD40_repeat	NWD2 WDR12 ELP2 WDR41 CFAP43 TEP1	1.70e-03	272	87	6	IPR001680
Domain	uDENN	DENND5B DENND5A	1.88e-03	14	87	2	SM00800
Domain	P_typ_ATPase_c	ATP8B4 ATP9A	1.88e-03	14	87	2	IPR032630
Domain	P-type_ATPase_N	ATP8B4 ATP9A	1.88e-03	14	87	2	IPR032631
Domain	P-type_ATPase_IV	ATP8B4 ATP9A	1.88e-03	14	87	2	IPR006539
Domain	PhoLip_ATPase_C	ATP8B4 ATP9A	1.88e-03	14	87	2	PF16212
Domain	PhoLip_ATPase_N	ATP8B4 ATP9A	1.88e-03	14	87	2	PF16209
Domain	WD_REPEATS_1	NWD2 WDR12 ELP2 WDR41 CFAP43 TEP1	1.90e-03	278	87	6	PS00678
Domain	WD_REPEATS_2	NWD2 WDR12 ELP2 WDR41 CFAP43 TEP1	1.93e-03	279	87	6	PS50082
Domain	WD_REPEATS_REGION	NWD2 WDR12 ELP2 WDR41 CFAP43 TEP1	1.93e-03	279	87	6	PS50294
Domain	uDENN	DENND5B DENND5A	2.17e-03	15	87	2	PF03456
Domain	UDENN	DENND5B DENND5A	2.47e-03	16	87	2	PS50946
Domain	DDENN	DENND5B DENND5A	2.47e-03	16	87	2	PS50947
Domain	DENN	DENND5B DENND5A	2.47e-03	16	87	2	SM00799
Domain	dDENN	DENND5B DENND5A	2.47e-03	16	87	2	SM00801
Domain	DENN	DENND5B DENND5A	2.47e-03	16	87	2	PF02141
Domain	dDENN_dom	DENND5B DENND5A	2.47e-03	16	87	2	IPR005112
Domain	uDENN_dom	DENND5B DENND5A	2.47e-03	16	87	2	IPR005113
Domain	dDENN	DENND5B DENND5A	2.47e-03	16	87	2	PF03455
Domain	DENN	DENND5B DENND5A	2.47e-03	16	87	2	PS50211
Domain	DENN_dom	DENND5B DENND5A	2.47e-03	16	87	2	IPR001194
Domain	WD40_repeat_dom	NWD2 WDR12 ELP2 WDR41 CFAP43 TEP1	2.64e-03	297	87	6	IPR017986
Domain	RUN	DENND5B DENND5A	3.13e-03	18	87	2	SM00593
Domain	RUN	DENND5B DENND5A	3.48e-03	19	87	2	PS50826
Domain	RUN	DENND5B DENND5A	3.48e-03	19	87	2	PF02759
Domain	Run_dom	DENND5B DENND5A	3.48e-03	19	87	2	IPR004012
Domain	-	RRP12 HEATR5A CTNNB1 ECPAS GCN1	3.80e-03	222	87	5	1.25.10.10
Domain	PLAT	DENND5B DENND5A	4.25e-03	21	87	2	PS50095
Domain	-	DENND5B DENND5A	4.25e-03	21	87	2	2.60.60.20
Domain	PLAT	DENND5B DENND5A	4.25e-03	21	87	2	PF01477
Domain	PLAT/LH2_dom	DENND5B DENND5A	4.25e-03	21	87	2	IPR001024
Domain	HEAT_REPEAT	HEATR5A ECPAS GCN1	4.27e-03	70	87	3	PS50077
Pathway	WP_WNTBETACATENIN_SIGNALING_INHIBITORS_IN_CURRENT_AND_PAST_CLINICAL_TRIALS	PORCN CTNNB1 CREBBP	4.99e-07	5	53	3	M48304
Pathway	BIOCARTA_IL7_PATHWAY	PIK3CA CREBBP IL7R	2.71e-05	16	53	3	M1296
Pathway	BIOCARTA_IL7_PATHWAY	PIK3CA CREBBP IL7R	2.71e-05	16	53	3	MM1420
Pathway	REACTOME_LRR_FLII_INTERACTING_PROTEIN_1_LRRFIP1_ACTIVATES_TYPE_I_IFN_PRODUCTION	CTNNB1 CREBBP	1.38e-04	5	53	2	M27228
Pubmed	Inhibition of CBP/β-catenin and porcupine attenuates Wnt signaling and induces apoptosis in head and neck carcinoma cells.	PORCN CTNNB1 CREBBP	1.68e-08	3	90	3	31089983
Pubmed	Activation of Hedgehog signaling by loss of GNAS causes heterotopic ossification.	HHAT GNAS CTNNB1	5.97e-06	14	90	3	24076664
Pubmed	CTNNB1 mutations in basal cell adenoma of the salivary gland.	PIK3CA CTNNB1	6.62e-06	2	90	2	29224720
Pubmed	Oncogenic β-catenin and PIK3CA instruct network states and cancer phenotypes in intestinal organoids.	PIK3CA CTNNB1	6.62e-06	2	90	2	28442534
Pubmed	Mas-Related G-Protein Coupled Receptors and Cowhage-Induced Itch.	MRGPRX1 MRGPRX2	6.62e-06	2	90	2	28988117
Pubmed	WNT signaling and distant metastasis in colon cancer through transcriptional activity of nuclear β-Catenin depend on active PI3K signaling.	PIK3CA CTNNB1	6.62e-06	2	90	2	24930890
Pubmed	Disruption of β-catenin/CBP signaling inhibits human airway epithelial-mesenchymal transition and repair.	CTNNB1 CREBBP	6.62e-06	2	90	2	26315281
Pubmed	A Golgi-based KDELR-dependent signalling pathway controls extracellular matrix degradation.	KDELR2 KDELR1	6.62e-06	2	90	2	25682866
Pubmed	Wnt/β-catenin signaling is differentially regulated by Gα proteins and contributes to fibrous dysplasia.	GNAS CTNNB1	6.62e-06	2	90	2	22106277
Pubmed	β-catenin/CBP activation of mTORC1 signaling promotes partial epithelial-mesenchymal states in head and neck cancer.	CTNNB1 CREBBP	6.62e-06	2	90	2	37353110
Pubmed	KDEL receptor regulates secretion by lysosome relocation- and autophagy-dependent modulation of lipid-droplet turnover.	KDELR2 KDELR1	6.62e-06	2	90	2	30760704
Pubmed	Kaposi's Sarcoma-Associated Herpesvirus Viral Interferon Regulatory Factor 4 (vIRF4) Perturbs the G1-S Cell Cycle Progression via Deregulation of the cyclin D1 Gene.	CTNNB1 CREBBP	6.62e-06	2	90	2	26491150
Pubmed	Distinct β-catenin and PIK3CA mutation profiles in endometriosis-associated ovarian endometrioid and clear cell carcinomas.	PIK3CA CTNNB1	6.62e-06	2	90	2	26276776
Pubmed	KDELR2 is necessary for chronic obstructive pulmonary disease airway Mucin5AC hypersecretion via an IRE1α/XBP-1s-dependent mechanism.	KDELR2 MUC5AC	6.62e-06	2	90	2	39365189
Pubmed	Functional analysis of novel phosphorylation sites of CREB-binding protein using mass spectrometry and mammalian two-hybrid assays.	CTNNB1 CREBBP	6.62e-06	2	90	2	21751375
Pubmed	Transmembrane protein 64 reciprocally regulates osteoblast and adipocyte differentiation by modulating Wnt/β-catenin signaling.	CTNNB1 TMEM64	6.62e-06	2	90	2	25979161
Pubmed	DRG afferents that mediate physiologic and pathologic mechanosensation from the distal colon.	PIEZO2 MRGPRX1 MRGPRX2	7.45e-06	15	90	3	37541195
Pubmed	Mapping the MOB proteins' proximity network reveals a unique interaction between human MOB3C and the RNase P complex.	PDE3A SLC4A7 DOCK7 WDR12 CTNNB1 RPP14 DOCK6 GCN1	9.55e-06	399	90	8	37536630
Pubmed	C-LTMRs mediate wet dog shakes via the spinoparabrachial pathway.	PIEZO2 MRGPRX1 MRGPRX2	1.58e-05	19	90	3	38915692
Pubmed	CBP-dependent Wnt/β-catenin signaling is crucial in regulation of MDR1 transcription.	CTNNB1 CREBBP	1.98e-05	3	90	2	25968898
Pubmed	Mutual antagonism of Wilms' tumor 1 and β-catenin dictates podocyte health and disease.	CTNNB1 CREBBP	1.98e-05	3	90	2	25071087
Pubmed	Mutations in TP53, CTNNB1 and PIK3CA genes in hepatocellular carcinoma associated with hepatitis B and hepatitis C virus infections.	PIK3CA CTNNB1	1.98e-05	3	90	2	23583669
Pubmed	Differential roles for the coactivators CBP and p300 on TCF/beta-catenin-mediated survivin gene expression.	CTNNB1 CREBBP	1.98e-05	3	90	2	15782138
Pubmed	Cell-type-specific differences in KDEL receptor clustering in mammalian cells.	KDELR2 KDELR1	1.98e-05	3	90	2	32645101
Pubmed	TREM2 and β-catenin regulate bone homeostasis by controlling the rate of osteoclastogenesis.	TREM2 CTNNB1	1.98e-05	3	90	2	22312126
Pubmed	Interactions between β-catenin and transforming growth factor-β signaling pathways mediate epithelial-mesenchymal transition and are dependent on the transcriptional co-activator cAMP-response element-binding protein (CREB)-binding protein (CBP).	CTNNB1 CREBBP	1.98e-05	3	90	2	22241478
Pubmed	Expression and clinical significance of IL7R, NFATc2, and RNF213 in familial and sporadic multiple sclerosis.	RNF213 IL7R	1.98e-05	3	90	2	34584155
Pubmed	Integrated Genomic Characterization of Pancreatic Ductal Adenocarcinoma.	GNAS CTNNB1	1.98e-05	3	90	2	28810144
Pubmed	TREM2 acts as a tumor suppressor in hepatocellular carcinoma by targeting the PI3K/Akt/β-catenin pathway.	TREM2 CTNNB1	1.98e-05	3	90	2	30683932
Pubmed	Small-molecule inhibitors of phosphatidylinositol 3-kinase/Akt signaling inhibit Wnt/beta-catenin pathway cross-talk and suppress medulloblastoma growth.	PIK3CA CTNNB1	1.98e-05	3	90	2	20028853
Pubmed	PIK3CA mutations and amplification in endometrioid endometrial carcinomas: relation to other genetic defects and clinicopathologic status of the tumors.	PIK3CA CTNNB1	1.98e-05	3	90	2	21531001
Pubmed	Phosphorylation of beta-catenin by cyclic AMP-dependent protein kinase.	CTNNB1 CREBBP	1.98e-05	3	90	2	16476742
Pubmed	A molecular specificity code for the three mammalian KDEL receptors.	KDELR2 KDELR1	1.98e-05	3	90	2	18086916
Pubmed	Targeting β-catenin overcomes MEK inhibition resistance in colon cancer with KRAS and PIK3CA mutations.	PIK3CA CTNNB1	1.98e-05	3	90	2	30944457
Pubmed	Convergence of Canonical and Non-Canonical Wnt Signal: Differential Kat3 Coactivator Usage.	CTNNB1 CREBBP	1.98e-05	3	90	2	30836930
Pubmed	Novel mutations target distinct subgroups of medulloblastoma.	PIK3CA CTNNB1	1.98e-05	3	90	2	22722829
Pubmed	Calcium sensing receptor suppresses human pancreatic tumorigenesis through a novel NCX1/Ca(2+)/β-catenin signaling pathway.	SLC8A1 CTNNB1	1.98e-05	3	90	2	27108064
Pubmed	Acetylation of beta-catenin by CREB-binding protein (CBP).	CTNNB1 CREBBP	1.98e-05	3	90	2	11973335
Pubmed	Shp2 deletion in hepatocytes suppresses hepatocarcinogenesis driven by oncogenic β-Catenin, PIK3CA and MET.	PIK3CA CTNNB1	1.98e-05	3	90	2	29505847
Pubmed	miR-149 contributes to resistance of 5-FU in gastric cancer via targeting TREM2 and regulating β-catenin pathway.	TREM2 CTNNB1	1.98e-05	3	90	2	32977944
Pubmed	The dynamic organisation of the secretory pathway.	KDELR2 KDELR1	1.98e-05	3	90	2	9118249
Pubmed	Genotype-specific cortisol production associated with Cushing's syndrome adenoma with PRKACA mutations.	GNAS CTNNB1	1.98e-05	3	90	2	34520814
Pubmed	Discovery of Aberrant Alteration of Genome in Colorectal Cancer by Exome Sequencing.	PIK3CA CTNNB1	1.98e-05	3	90	2	31445671
Pubmed	Membrane bound O-acyltransferases and their inhibitors.	HHAT PORCN	1.98e-05	3	90	2	25849925
Pubmed	Sam68 Allows Selective Targeting of Human Cancer Stem Cells.	CTNNB1 CREBBP	1.98e-05	3	90	2	28648376
Pubmed	Regulation of Human Airway Epithelial Tissue Stem Cell Differentiation by β-Catenin, P300, and CBP.	CTNNB1 CREBBP	1.98e-05	3	90	2	30171668
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	KDELR2 NLGN3 MYCBP2 RALGAPB TVP23C PORCN RNF213 DENND5A GNAS ECPAS TEP1 DOCK6 CREBBP SLC4A5	2.81e-05	1489	90	14	28611215
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	URB1 NRSN2 EXD2 SLC43A1 B3GNT2 RRP12 TVP23C CTNNB1 ATP9A ECPAS GCN1	3.22e-05	942	90	11	31073040
Pubmed	Erasure of Tet-Oxidized 5-Methylcytosine by a SRAP Nuclease.	FBXO33 GNAS	3.96e-05	4	90	2	29020633
Pubmed	CXCR2 Inhibition in Human Pluripotent Stem Cells Induces Predominant Differentiation to Mesoderm and Endoderm Through Repression of mTOR, β-Catenin, and hTERT Activities.	CTNNB1 CXCR2	3.96e-05	4	90	2	27188501
Pubmed	Activation of MrgprA3 and MrgprC11 on Bladder-Innervating Afferents Induces Peripheral and Central Hypersensitivity to Bladder Distension.	MRGPRX1 MRGPRX2	3.96e-05	4	90	2	33727332
Pubmed	Keratinocyte-derived defensins activate neutrophil-specific receptors Mrgpra2a/b to prevent skin dysbiosis and bacterial infection.	MRGPRX1 MRGPRX2	3.96e-05	4	90	2	35882236
Pubmed	Molecular Signature of Pruriceptive MrgprA3+ Neurons.	MRGPRX1 MRGPRX2	3.96e-05	4	90	2	32234460
Pubmed	Thymine DNA glycosylase is a positive regulator of Wnt signaling in colorectal cancer.	CTNNB1 CREBBP	3.96e-05	4	90	2	24532795
Pubmed	AT-rich interactive domain 2, p110α, p53, and β-catenin protein expression in hepatocellular carcinoma and clinicopathologic implications.	PIK3CA CTNNB1	3.96e-05	4	90	2	25701229
Pubmed	Low maternal care enhances the skin barrier resistance of offspring in mice.	MRGPRX1 MRGPRX2	3.96e-05	4	90	2	31295326
Pubmed	Molecular expression of SLC4-derived Na+-dependent anion transporters in selected human tissues.	SLC4A7 SLC4A5	3.96e-05	4	90	2	17715183
Pubmed	Deletion of Porcn in mice leads to multiple developmental defects and models human focal dermal hypoplasia (Goltz syndrome).	PORCN CTNNB1	3.96e-05	4	90	2	22412863
Pubmed	CBP-mediated Wnt3a/β-catenin signaling promotes cervical oncogenesis initiated by Piwil2.	CTNNB1 CREBBP	3.96e-05	4	90	2	33190089
Pubmed	Wnt/beta-catenin/CBP signaling maintains long-term murine embryonic stem cell pluripotency.	CTNNB1 CREBBP	3.96e-05	4	90	2	17372190
Pubmed	MrgprA3 shows sensitization to chloroquine in an acetone-ether-water mice model.	MRGPRX1 MRGPRX2	3.96e-05	4	90	2	29064954
Pubmed	Role of the N-terminal activation domain of the coiled-coil coactivator in mediating transcriptional activation by beta-catenin.	CTNNB1 CREBBP	3.96e-05	4	90	2	16931570
Pubmed	Knockout of Rnf213 Ameliorates Cerebral Ischemic-reperfusion Injury by Inhibiting Neuronal Apoptosis Through the Akt/GSK-3β/β-catenin/Bcl-2 Pathway.	RNF213 CTNNB1	3.96e-05	4	90	2	37778692
Pubmed	Cell-type-specific function of BCL9 involves a transcriptional activation domain that synergizes with beta-catenin.	CTNNB1 CREBBP	3.96e-05	4	90	2	18347063
Pubmed	A mechanically activated ion channel is functionally expressed in the MrgprB4 positive sensory neurons, which detect stroking of hairy skin in mice.	MRGPRX1 MRGPRX2	3.96e-05	4	90	2	28545921
Pubmed	Substance P activates Mas-related G protein-coupled receptors to induce itch.	MRGPRX1 MRGPRX2	3.96e-05	4	90	2	28219706
Pubmed	cAMP-responding element-binding protein and c-Ets1 interact in the regulation of ATP-dependent MUC5AC gene expression.	MUC5AC CREBBP	3.96e-05	4	90	2	18676374
Pubmed	Cloning and functional expression of a novel Gi protein-coupled receptor for adenine from mouse brain.	MRGPRX1 MRGPRX2	3.96e-05	4	90	2	17975009
Pubmed	Characterization of new G protein-coupled adenine receptors in mouse and hamster.	MRGPRX1 MRGPRX2	3.96e-05	4	90	2	23608776
Pubmed	Voltage-gated potassium channels involved in regulation of physiological function in MrgprA3-specific itch neurons.	MRGPRX1 MRGPRX2	3.96e-05	4	90	2	26874069
Pubmed	CBP/catenin antagonist safely eliminates drug-resistant leukemia-initiating cells.	CTNNB1 CREBBP	3.96e-05	4	90	2	26657156
Pubmed	Distinct Spatiotemporally Dynamic Wnt-Secreting Niches Regulate Proximal Airway Regeneration and Aging.	PORCN CTNNB1	3.96e-05	4	90	2	32721381
Pubmed	FGFR2 point mutations in 466 endometrioid endometrial tumors: relationship with MSI, KRAS, PIK3CA, CTNNB1 mutations and clinicopathological features.	PIK3CA CTNNB1	3.96e-05	4	90	2	22383975
Pubmed	Molecular genetic visualization of a rare subset of unmyelinated sensory neurons that may detect gentle touch.	MRGPRX1 MRGPRX2	6.59e-05	5	90	2	17618277
Pubmed	A Regulatory Network Involving β-Catenin, e-Cadherin, PI3k/Akt, and Slug Balances Self-Renewal and Differentiation of Human Pluripotent Stem Cells In Response to Wnt Signaling.	PIK3CA CTNNB1	6.59e-05	5	90	2	25538040
Pubmed	Mutational analysis of TP53, PTEN, PIK3CA and CTNNB1/beta-catenin genes in human herpesvirus 8-associated primary effusion lymphoma.	PIK3CA CTNNB1	6.59e-05	5	90	2	19608668
Pubmed	Hippocampal short- and long-term plasticity are not modulated by astrocyte Ca2+ signaling.	MRGPRX1 MRGPRX2	6.59e-05	5	90	2	20203048
Pubmed	Inhibition of viral pathogenesis and promotion of the septic shock response to bacterial infection by IRF-3 are regulated by the acetylation and phosphorylation of its coactivators.	CTNNB1 CREBBP	6.59e-05	5	90	2	23532979
Pubmed	MrgprB4 in trigeminal neurons expressing TRPA1 modulates unpleasant sensations.	MRGPRX1 MRGPRX2	6.59e-05	5	90	2	34116733
Pubmed	Astrocytes modulate neural network activity by Ca²+-dependent uptake of extracellular K+.	MRGPRX1 MRGPRX2	6.59e-05	5	90	2	22472648
Pubmed	Cross-sensitization of histamine-independent itch in mouse primary sensory neurons.	MRGPRX1 MRGPRX2	6.59e-05	5	90	2	23000623
Pubmed	Prognostic significance and molecular associations of 18q loss of heterozygosity: a cohort study of microsatellite stable colorectal cancers.	PIK3CA CTNNB1	6.59e-05	5	90	2	19704056
Pubmed	Sensory neuron-specific GPCR Mrgprs are itch receptors mediating chloroquine-induced pruritus.	MRGPRX1 MRGPRX2	6.59e-05	5	90	2	20004959
Pubmed	Interaction and functional cooperation between the LIM protein FHL2, CBP/p300, and beta-catenin.	CTNNB1 CREBBP	6.59e-05	5	90	2	15572674
Pubmed	Obesity promotes PhIP-induced small intestinal carcinogenesis in hCYP1A-db/db mice: involvement of mutations and DNA hypermethylation of Apc.	DOCK7 CTNNB1	6.59e-05	5	90	2	27207656
Pubmed	Proteinase-activated receptor-2 induces cyclooxygenase-2 expression through beta-catenin and cyclic AMP-response element-binding protein.	CTNNB1 CREBBP	6.59e-05	5	90	2	17962194
Pubmed	Regional Differences in Itch Transmission.	MRGPRX1 MRGPRX2	6.59e-05	5	90	2	38735364
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	NWD2 DENND5A GCN1 CYFIP2	7.92e-05	87	90	4	12465718
Pubmed	Visualizing the Itch-Sensing Skin Arbors.	MRGPRX1 MRGPRX2	9.87e-05	6	90	2	33091423
Pubmed	Thymine DNA glycosylase promotes transactivation of β-catenin/TCFs by cooperating with CBP.	CTNNB1 CREBBP	9.87e-05	6	90	2	24748645
Pubmed	Genetic identification of C fibres that detect massage-like stroking of hairy skin in vivo.	MRGPRX1 MRGPRX2	9.87e-05	6	90	2	23364746
Pubmed	Identification of a bilirubin receptor that may mediate a component of cholestatic itch.	MRGPRX1 MRGPRX2	9.87e-05	6	90	2	30657454
Pubmed	Bach1 Represses Wnt/β-Catenin Signaling and Angiogenesis.	CTNNB1 CREBBP	9.87e-05	6	90	2	26123998
Pubmed	PI3Kα-regulated gelsolin activity is a critical determinant of cardiac cytoskeletal remodeling and heart disease.	PIK3CA CTNNB1	9.87e-05	6	90	2	30568254
Pubmed	A subpopulation of nociceptors specifically linked to itch.	MRGPRX1 MRGPRX2	9.87e-05	6	90	2	23263443
Pubmed	ICAT inhibits beta-catenin binding to Tcf/Lef-family transcription factors and the general coactivator p300 using independent structural modules.	CTNNB1 CREBBP	9.87e-05	6	90	2	12408825
Pubmed	Enhanced excitability of MRGPRA3- and MRGPRD-positive nociceptors in a model of inflammatory itch and pain.	MRGPRX1 MRGPRX2	9.87e-05	6	90	2	24549959
Pubmed	The beta-catenin axis integrates multiple signals downstream from RET/papillary thyroid carcinoma leading to cell proliferation.	CTNNB1 CREBBP	1.38e-04	7	90	2	19223551
Pubmed	A ZNRF3-dependent Wnt/β-catenin signaling gradient is required for adrenal homeostasis.	PORCN CTNNB1	1.38e-04	7	90	2	30692207
Pubmed	Crooked tail (Cd) model of human folate-responsive neural tube defects is mutated in Wnt coreceptor lipoprotein receptor-related protein 6.	MESD CTNNB1	1.38e-04	7	90	2	16126904
Interaction	VIPR1 interactions	KDELR2 KDELR1 TVP23C GNAS ATP12A ECPAS GCN1 CYFIP2	2.25e-06	205	84	8	int:VIPR1
Interaction	IL13RA2 interactions	PIK3CA B3GNT2 TVP23C ATP12A ECPAS GCN1	2.23e-05	136	84	6	int:IL13RA2
Interaction	OPALIN interactions	KDELR2 SLC4A7 KDELR1 RNF213 TMEM39B ECPAS GCN1	2.69e-05	209	84	7	int:OPALIN
Interaction	FPR1 interactions	URB1 TMEM161B RNF213 ATP12A ECPAS GCN1	3.46e-05	147	84	6	int:FPR1
Interaction	ISM2 interactions	DPY19L3 DOCK7 DOCK6	3.76e-05	16	84	3	int:ISM2
GeneFamily	WD repeat domain containing	WDR12 ELP2 WDR41 CFAP43 TEP1	6.97e-04	262	49	5	362
GeneFamily	ATPase phospholipid transporting	ATP8B4 ATP9A	7.39e-04	15	49	2	1210
GeneFamily	G protein-coupled receptors, Class A orphans	GPR25 MRGPRX1 MRGPRX2	1.23e-03	78	49	3	262
GeneFamily	Guanylate cyclase receptors\|DENN/MADD domain containing	DENND5B DENND5A	2.07e-03	25	49	2	504
GeneFamily	Solute carriers	SLC8A1 SLC4A7 SLC2A6 SLC43A1 SLC4A5	4.20e-03	395	49	5	752
GeneFamily	CD molecules\|I-set domain containing\|Immunoglobulin like domain containing\|Interleukin receptors\|TIR domain containing	IL7R CXCR2	5.78e-03	42	49	2	602
ToppCell	Secretory\|World / shred by cell class for bronchial biopsy	KDELR2 GNAS TMEM125 ATP12A TMC5 MUC5AC	2.82e-06	195	90	6	52f8281fe0df67cec3faa780a23ed6343ed5a6ba
ToppCell	TCGA-Cervix-Primary_Tumor-Endocervical_Adenocarcinoma-Mucinous_Adenocarcinoma\|TCGA-Cervix / Sample_Type by Project: Shred V9	PECR CFAP43 TMEM125 TMC5 MUC5AC	2.53e-05	171	90	5	1af575809b3334bfaa019ff26c56e6cb03c82ee8
ToppCell	5'-Adult-Appendix-Hematopoietic-T_cells-NK_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ATP8B4 RNF213 SLC4A5 CYFIP2 CXCR2	2.60e-05	172	90	5	f3c16a62eba1ed190318beee131c71c5150b266a
ToppCell	droplet-Lung-LUNG-30m-Lymphocytic-Ly6g5b+_T\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DPY19L3 PRELID2 LRRN4 TMEM64 IL7R	3.24e-05	180	90	5	5c649e2b3f5a53c0040b69df6e289fb3427ef2db
ToppCell	droplet-Lung-30m-Hematologic-lymphocytic-immature_innate_lymphoid_cell\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DPY19L3 PRELID2 LRRN4 TMEM64 IL7R	3.59e-05	184	90	5	3d8008f8d2e39c0d7a3cabc45620027491da03cf
ToppCell	droplet-Lung-30m-Hematologic-lymphocytic-immature_innate_lymphoid_cell-Ly6g5b+_T\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DPY19L3 PRELID2 LRRN4 TMEM64 IL7R	3.59e-05	184	90	5	eeed75984ff111c0d1750df2f978163a42f20207
ToppCell	CV-Moderate-7\|Moderate / Virus stimulation, Condition and Cluster	URB1 ATP8B4 MYCBP2 TMEM161B RNF213	3.69e-05	185	90	5	a6c9203ce6c2892a4a369c9bcfb85720f01cbb3f
ToppCell	Substantia_nigra-Neuronal-Inhibitory\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	NRSN2 NWD2 MYCBP2 PIK3CA PLCXD2	3.78e-05	186	90	5	9d3efe2a4feea2bc205a7e45b9b9f9ed9b3609ce
ToppCell	CV-Moderate-7\|CV / Virus stimulation, Condition and Cluster	URB1 ATP8B4 MYCBP2 TMEM161B RNF213	3.78e-05	186	90	5	8571956890fc9894d766ba294a28e376b4aba428
ToppCell	Adult-Endothelial-endothelial_cell_of_lymph_vessel-D175\|Adult / Lineage, Cell type, age group and donor	SEMA3D PIEZO2 CCM2L LRRC3B DOCK6	3.88e-05	187	90	5	1e52d3d9d664c813d859b5b75e4c07b218818f95
ToppCell	Substantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	NRSN2 NWD2 MYCBP2 LRRC3B PLCXD2	3.98e-05	188	90	5	b73e8a40393c3f656e2fcfe395a761b1f985c254
ToppCell	CD8+_Memory_T_cell-CV-7\|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster	URB1 ATP8B4 MYCBP2 TMEM161B RNF213	4.29e-05	191	90	5	9454f642c3621370fa23640b631301346b300950
ToppCell	10x_3'_v2v3-Non-neoplastic-Lymphoid-CD4/CD8-CD8_cytotoxic-C\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	MESD MYCBP2 PLCXD2 RNF213 POLL	4.74e-05	195	90	5	83c125223e7ca0f08a31414b3a16347912564765
ToppCell	Bronchial_Biopsy-Epithelial-Club\|Bronchial_Biopsy / Tissue, Lineage and Cell class of Lung Cells from 10X	KDELR2 TMEM125 ATP12A TMC5 MUC5AC	4.85e-05	196	90	5	057d150bdf0cad959fd03ec2d1560a96ba03fae9
ToppCell	Bronchial_Biopsy-Epithelial-Club\|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X	KDELR2 TMEM125 ATP12A TMC5 MUC5AC	4.97e-05	197	90	5	3f5dfa892a1f631b96eeb6f4cfc284aee51d1ce6
ToppCell	Transverse-(5)_Dendritic_cell-(53)_Lymphoid_DC\|Transverse / shred on region, Cell_type, and subtype	NLGN3 PIEZO2 SNX18 TREM2 DENND5A	4.97e-05	197	90	5	15b87fd3906d7388c271d30d0c64b1bcc490801c
ToppCell	Transverse-Dendritic_cell-Lymphoid_DC\|Transverse / Region, Cell class and subclass	NLGN3 PIEZO2 SNX18 TREM2 DENND5A	4.97e-05	197	90	5	a58af0ea82f76f2a7abac1f62629ff20d552fc63
ToppCell	Tracheal-10x5prime-Endothelial-Endothelia_lymphatic\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	SEMA3D PIEZO2 LRRC3B MOV10L1 DOCK6	5.09e-05	198	90	5	05429f18e1d74880c1835568c86177f661b3477a
ToppCell	Tracheal-10x5prime-Endothelial-Endothelia_lymphatic-Endothelia_Lymphatic\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	SEMA3D PIEZO2 LRRC3B MOV10L1 DOCK6	5.09e-05	198	90	5	306e28d31fd587409a12dcccc6b2abd7dc9c2e0a
Disease	Ovarian neoplasm	PIK3CA CTNNB1	1.59e-04	7	82	2	cv:C0919267
Disease	HEPATOCELLULAR CARCINOMA	PIK3CA CTNNB1	2.71e-04	9	82	2	114550
Disease	Adult Hepatocellular Carcinoma	PIK3CA CTNNB1	2.71e-04	9	82	2	C0279607
Disease	Hepatocellular carcinoma	PIK3CA CTNNB1	2.71e-04	9	82	2	cv:C2239176
Disease	Adrenal Gland Neoplasms	GNAS CTNNB1	4.13e-04	11	82	2	C0001624
Disease	Adrenal Cancer	GNAS CTNNB1	4.13e-04	11	82	2	C0750887
Disease	level of Phosphatidylinositol (18:1_18:1) in blood serum	DOCK7 DOCK6	5.83e-04	13	82	2	OBA_2045159
Disease	Schizophrenia	ANKK1 PRODH2 SEMA3D PIK3CA HHAT B3GNT2 GNAS CTNNB1 CNTF	7.69e-04	883	82	9	C0036341
Disease	anemia (implicated_via_orthology)	SLC4A7 SLC4A5	7.82e-04	15	82	2	DOID:2355 (implicated_via_orthology)
Disease	autism spectrum disorder (implicated_via_orthology)	NLGN3 ELP2 CTNNB1 CREBBP	8.67e-04	152	82	4	DOID:0060041 (implicated_via_orthology)
Disease	stomach cancer (is_implicated_in)	PIK3CA TEP1 IL7R	1.07e-03	72	82	3	DOID:10534 (is_implicated_in)
Disease	level of Phosphatidylinositol (18:0_18:1) in blood serum	DOCK7 DOCK6	1.13e-03	18	82	2	OBA_2045155
Disease	level of Phosphatidylinositol (18:0_18:2) in blood serum	DOCK7 DOCK6	1.55e-03	21	82	2	OBA_2045156
Disease	Osteogenesis imperfecta	KDELR2 MESD	1.55e-03	21	82	2	cv:C0029434
Disease	level of Phosphatidylinositol (18:0_20:4) in blood serum	DOCK7 DOCK6	1.86e-03	23	82	2	OBA_2045158
Disease	Neoplasm of the genitourinary tract	PIK3CA CTNNB1	2.02e-03	24	82	2	cv:C0042065
Disease	inflammatory biomarker measurement	SLC8A1 PIEZO2	2.37e-03	26	82	2	EFO_0004872
Disease	Colorectal cancer	PIK3CA CTNNB1	2.56e-03	27	82	2	cv:C0346629
Disease	COLORECTAL CANCER	PIK3CA CTNNB1	2.56e-03	27	82	2	114500
Disease	Neoplasm of the large intestine	PIK3CA CTNNB1	2.56e-03	27	82	2	cv:C0009404
Disease	Adenocarcinoma of lung (disorder)	SLC4A7 PIK3CA CTNNB1 CREBBP	2.64e-03	206	82	4	C0152013
Disease	upper respiratory tract disorder	FBXO33 IL7R	2.75e-03	28	82	2	MONDO_0004867
Disease	anterior thigh muscle fat infiltration measurement	PDE3A HHAT	2.75e-03	28	82	2	EFO_0020936

Protein segments in the cluster

Peptide	Gene	Start	Entry
LWLITIAKCGILCIR	CFAP43	651	Q8NDM7
LEKVLSTHSLCWKLR	ANKK1	106	Q8NFD2
LLLALRWGLTIATCL	GPR25	281	O00155
CKNSLTELLLRWALA	ANKRD18B	991	A2A2Z9
LRRSKWSTLCMLVEL	CREBBP	1681	Q92793
SLTQKCIWLVILLTT	ATP8B4	1061	Q8TF62
CTSRRLWKILSLTIG	DPY19L3	36	Q6ZPD9
LSLSARCLLLTWRDN	CCM2L	111	Q9NUG4
KSAWLSLCLQERRLV	POLL	111	Q9UGP5
TSTRLCKELASWVRR	PRODH2	241	Q9UF12
ICKALSIELLDTGLW	NWD2	1206	Q9ULI1
RKLVLLCFLLATLWE	PCDHGA2	11	Q9Y5H1
LLWTTSRVLKVLSVC	CTNNB1	336	P35222
IWKASRFRIIITTCS	MOV10L1	851	Q9BXT6
RTWASLSKIITLCNR	ATP12A	431	P54707
WARKAVVLLCASDLL	MESD	6	Q14696
RKSLCSPTFLWSLLT	SLC43A1	296	O75387
LLAWRCTKLSLLAIH	FBXO33	451	Q7Z6M2
AACIWLLSLVRKLST	ECPAS	961	Q5VYK3
KSLLLRCSNWDAETL	EXD2	221	Q9NVH0
SCLAAATWLVLRLRL	PDE3A	196	Q14432
LTKSLALEWACSGIR	PECR	181	Q9BY49
LVKFICLSIWGLSLL	CXCR2	161	P25025
LLASSILCALIVFWK	CT83	6	Q5H943
ATACWSVLKAKRRLL	MIGA2	471	Q7L4E1
FSVALLVILACVLWK	IL7R	251	P16871
SAALLALTWTCLLVR	GCN1	111	Q92616
LWLTRSLSMCLLLQS	LRRC3B	6	Q96PB8
RKLALLWALALALAC	MUC5AC	6	P98088
SFLWKVSVITLVSCL	ATP9A	1011	O75110
CWKISLSSGTLLLLL	NRSN2	61	Q9GZP1
LISVLQAIRKTICDW	CYFIP2	506	Q96F07
LCVLASWLTAFVLTK	SLC2A6	436	Q9UGQ3
SLWVINSALRIKILC	PIK3CA	326	P42336
ISFSWLSVLCVLKDT	PANX3	341	Q96QZ0
RSQLLTWLCSLLLLS	HHAT	131	Q5VTY9
TWLCSLLLLSTLRLQ	HHAT	136	Q5VTY9
SCRWLQKVARSLALA	PORCN	186	Q9H237
SLCLTLWFLSLALRA	NLGN3	21	Q9NZ94
LSLWLKLCKDVLAAS	HEATR5A	1161	Q86XA9
RTLLACVLWVLKNTE	DOCK6	1251	Q96HP0
SAESSRSLLICLLWV	DOCK7	1321	Q96N67
RSLLICLLWVLKNAD	DOCK7	1326	Q96N67
STTKCLNIWALILGI	nan	101	C9JQL5
LGCLLKVLLWVASAL	FITM1	21	A5D6W6
LCSRSIWLARKIRSD	CNTF	16	P26441
SWLLIFFILKSISCL	HYAL4	21	Q2M3T9
RRAATALLWLSCSIA	GNAS	26	O95467
ALLWLSCSIALLRAL	GNAS	31	O95467
TLIASLCDLLERIWS	DENND5B	776	Q6ZUT9
TLIASLCDLLERIWS	DENND5A	791	Q6IQ26
CLIRIWKLYIKSTSL	ELP2	231	Q6IA86
IILLLLKIWKSRSCA	KDELR1	16	P24390
IVILLLKIWKTRSCA	KDELR2	16	P33947
SCDLSWLLTDAKRTV	LRRN4	316	Q8WUT4
KTVSAVCSLAWHIRL	RSBN1L	676	Q6PCB5
HTFLICLASWVSRKI	TAS2R38	126	P59533
TCLVLLWVIKVSAAA	SLC4A7	1091	Q9Y6M7
ISLVWCLLVLSFAIK	TMEM161B	136	Q8NDZ6
ILTWEECVAALLTLK	OVCH2	201	Q7RTZ1
ATTRLWLALASLCVL	MYCBP2	4221	O75592
VVCVLLWALSLLRSI	MRGPRX1	141	Q96LB2
SAVVCVLLWALSLLL	MRGPRX2	146	Q96LB1
TLLESCVKWLIVSFS	URB1	1381	O60287
STSVLRWVLSCLATL	RRP12	206	Q5JTH9
RWVLSCLATLLRKQD	RRP12	211	Q5JTH9
LINKWTTFLKARLIC	SEMA3D	296	O95025
SLKEVLFLRWVSTSC	B3GNT2	221	Q9NY97
ACKTLRSLNLDWIAL	NLRP9	911	Q7RTR0
LLASCVSVWKTAAVL	RNF213	5186	Q63HN8
LFWKCLPSRTLTLET	TIGD2	181	Q4W5G0
VVCKRLLTAWVAARI	TMEM64	211	Q6YI46
LRERSSKIQCAWLLV	RNFT1	196	Q5M7Z0
RAIKRACTWSALALS	TEX13D	61	A0A0J9YY54
KWLEISCSLRKFSTL	UBTFL6	66	P0CB48
VTIILLLSCDFWAVK	TVP23C	66	Q96ET8
ALKECSLQSLWLLSR	TEP1	1996	Q99973
ACSVESLTLRTLWEK	PLCXD2	191	Q0VAA5
WSVLCRLKGATLTAV	SNX18	551	Q96RF0
AKLRRLASSVCTVWT	PIEZO2	976	Q9H5I5
LSLRSLTAVTCTVWL	PIGH	36	Q14442
ILRKSLSTLVILCWK	PRELID2	66	Q8N945
LSTLVILCWKKVSIL	PRELID2	71	Q8N945
LCLAVLWILKSTVAA	SLC4A5	1026	Q9BY07
RAIKRACTWSALALS	TEX13C	61	A0A0J9YWL9
QWSKVICALTSRLLR	RALGAPB	236	Q86X10
CIFLIKILAASALWA	TREM2	181	Q9NZC2
TGVLCTLAITIWRLK	TMC5	846	Q6UXY8
VTIILLLSCDFWAVK	TVP23B	66	Q9NYZ1
SLCRVLAVTWSLTKL	ZNF295-AS1	66	Q8N0V1
VAWVKKDSLSCLLLS	WDR12	146	Q9GZL7
RICSSGLVKLWSSLT	RPP14	76	O95059
WRLATGTVLCLLALL	TMEM125	66	Q96AQ2
VKCLTVLQRLDVWLS	WDR41	136	Q9HAD4
KRWSCELFLLVSIST	TMEM39B	316	Q9GZU3
RTAKLLTSCLFVLLW	SLC8A1	941	P32418