Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyCellularComponentendoplasmic reticulum lumen

PCSK7 THBS1 FUCA2 VTN F5 CES2

9.52e-05332476GO:0005788
GeneOntologyCellularComponentplatelet alpha granule lumen

VEGFC THBS1 F5

4.61e-0467473GO:0031093
GeneOntologyCellularComponentextrinsic component of postsynaptic membrane

OLFM2 TENM2

1.11e-0322472GO:0098890
GeneOntologyCellularComponentacrosomal vesicle

SPATA31A1 SPATA31A3 SPATA31A5 SPATA31A7

1.17e-03206474GO:0001669
GeneOntologyCellularComponentplatelet alpha granule

VEGFC THBS1 F5

1.20e-0393473GO:0031091
GeneOntologyCellularComponentsecretory granule

VEGFC THBS1 FUCA2 SPATA31A1 SPATA31A3 F5 SPATA31A5 SPATA31A7

1.74e-031014478GO:0030141
DomainDUF4599

SPATA31A3 SPATA31A5 SPATA31A7

3.23e-0612473PF15371
DomainDUF4599

SPATA31A3 SPATA31A5 SPATA31A7

3.23e-0612473IPR027970
DomainVWFC_1

KCP THBS1 SSPOP

1.01e-0436473PS01208
DomainVWC

KCP THBS1 SSPOP

1.18e-0438473SM00214
DomainVWFC_2

KCP THBS1 SSPOP

1.18e-0438473PS50184
DomainVWF_dom

KCP THBS1 SSPOP

1.60e-0442473IPR001007
DomainSomatomedin_B_dom

VTN SBSPON

2.75e-0410472IPR001212
DomainSMB_1

VTN SBSPON

2.75e-0410472PS00524
DomainSMB_2

VTN SBSPON

2.75e-0410472PS50958
DomainEGF_3

THBS1 MALRD1 SSPOP TENM2 ATRAID

3.01e-04235475PS50026
DomainPNT

ETV6 ETV7

3.36e-0411472PS51433
DomainPointed_dom

ETV6 ETV7

3.36e-0411472IPR003118
DomainSAM_PNT

ETV6 ETV7

3.36e-0411472PF02198
DomainSAM_PNT

ETV6 ETV7

3.36e-0411472SM00251
DomainEGF_1

THBS1 MALRD1 SSPOP TENM2 ATRAID

4.38e-04255475PS00022
DomainUnchr_dom_Cys-rich

KCP SSPOP

4.75e-0413472IPR014853
DomainC8

KCP SSPOP

4.75e-0413472SM00832
DomainEGF_2

THBS1 MALRD1 SSPOP TENM2 ATRAID

5.22e-04265475PS01186
DomainTSP_1

THBS1 SSPOP SBSPON

5.34e-0463473PF00090
DomainTIL_dom

KCP SSPOP

5.53e-0414472IPR002919
DomainTSP1

THBS1 SSPOP SBSPON

5.85e-0465473SM00209
DomainTSP1_rpt

THBS1 SSPOP SBSPON

5.85e-0465473IPR000884
DomainTSP1

THBS1 SSPOP SBSPON

5.85e-0465473PS50092
DomainVWD

KCP SSPOP

7.27e-0416472SM00216
DomainVWF_type-D

KCP SSPOP

7.27e-0416472IPR001846
DomainVWFD

KCP SSPOP

7.27e-0416472PS51233
DomainVWD

KCP SSPOP

7.27e-0416472PF00094
Domain-

PCSK7 SSPOP F5

8.21e-04734732.60.120.260
DomainVWC_out

KCP SSPOP

1.03e-0319472SM00215
DomainFA58C

SSPOP F5

1.26e-0321472SM00231
DomainFA58C_3

SSPOP F5

1.26e-0321472PS50022
DomainFA58C_1

SSPOP F5

1.26e-0321472PS01285
DomainFA58C_2

SSPOP F5

1.26e-0321472PS01286
DomainF5_F8_type_C

SSPOP F5

1.65e-0324472PF00754
DomainFA58C

SSPOP F5

1.65e-0324472IPR000421
DomainGalactose-bd-like

PCSK7 SSPOP F5

1.71e-0394473IPR008979
DomainETS_DOMAIN_1

ETV6 ETV7

2.25e-0328472PS00345
DomainETS_DOMAIN_2

ETV6 ETV7

2.25e-0328472PS00346
DomainETS

ETV6 ETV7

2.25e-0328472SM00413
DomainEts_dom

ETV6 ETV7

2.25e-0328472IPR000418
DomainETS_DOMAIN_3

ETV6 ETV7

2.25e-0328472PS50061
DomainEts

ETV6 ETV7

2.25e-0328472PF00178
DomainVWC

KCP THBS1

2.25e-0328472PF00093
DomainEGF

THBS1 MALRD1 TENM2 ATRAID

2.85e-03235474SM00181
DomainEGF-like_dom

THBS1 MALRD1 TENM2 ATRAID

3.51e-03249474IPR000742
DomainEGF-like_CS

THBS1 MALRD1 TENM2 ATRAID

4.15e-03261474IPR013032
DomainLDLR_class-A_CS

MALRD1 SSPOP

4.55e-0340472IPR023415
DomainLdl_recept_a

MALRD1 SSPOP

5.73e-0345472PF00057
Domain-

MALRD1 SSPOP

5.98e-03464724.10.400.10
DomainLDLRA_1

MALRD1 SSPOP

6.49e-0348472PS01209
DomainLDLRA_2

MALRD1 SSPOP

6.76e-0349472PS50068
DomainLDrepeatLR_classA_rpt

MALRD1 SSPOP

6.76e-0349472IPR002172
DomainLDLa

MALRD1 SSPOP

6.76e-0349472SM00192
PathwayREACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS

THBS1 SSPOP SBSPON

6.81e-0539293M27417
PathwayREACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS

THBS1 SSPOP SBSPON

6.81e-0539293MM15165
Pubmed

The testis-specific VAD1.3/AEP1 interacts with β-actin and syntaxin 1 and directs peri-nuclear/Golgi expression with bipartite nucleus localization (BNL) sequence.

SPATA31A1 SPATA31A3 SPATA31A5 SPATA31A7

4.78e-11648420850414
Pubmed

Targeted disruption of the spermatid-specific gene Spata31 causes male infertility.

SPATA31A1 SPATA31A3 SPATA31A5 SPATA31A7

4.78e-11648425930072
Pubmed

Majority of cerebrospinal fluid-contacting neurons in the spinal cord of C57Bl/6N mice is present in ectopic position unlike in other studied experimental mice strains and mammalian species.

SPATA31A1 SPATA31A3 HERPUD2 SPATA31A5 SPATA31A7

1.68e-102448532212159
Pubmed

Tel-2 is a novel transcriptional repressor related to the Ets factor Tel/ETV-6.

ETV6 ETV7

1.87e-06248211108721
Pubmed

Thrombospondin 1, fibronectin, and vitronectin are differentially dependent upon RAS, ERK1/2, and p38 for induction of vascular smooth muscle cell chemotaxis.

THBS1 VTN

1.87e-06248221193465
Pubmed

Repeating structures of the major staphylococcal autolysin are essential for the interaction with human thrombospondin 1 and vitronectin.

THBS1 VTN

1.87e-06248224371140
Pubmed

Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury.

APOL4 THBS1 VTN SSPOP

1.91e-066448422261194
Pubmed

The human L(3)MBT polycomb group protein is a transcriptional repressor and interacts physically and functionally with TEL (ETV6).

ETV6 ETV7

5.59e-06348212588862
Pubmed

Association of thrombogenic genes polymorphisms with hepatocellular carcinoma in HCV Egyptian patients.

THBS1 F5

5.59e-06348226768578
Pubmed

Silencing METTL3 Stabilizes Atherosclerotic Plaques by Regulating the Phenotypic Transformation of Vascular Smooth Muscle Cells via the miR-375-3p/PDK1 Axis.

METTL3 PDPK1

1.12e-05448235704246
Pubmed

Thrombospondin-1 promotes liver fibrosis by enhancing TGF-β action in hepatic stellate cells.

THBS1 PDPK1

1.12e-05448238091840
Pubmed

Osteoprotegerin (OPG) is localized to the Weibel-Palade bodies of human vascular endothelial cells and is physically associated with von Willebrand factor.

THBS1 VTN

1.86e-05548215799029
Pubmed

Polymorphisms in hypoxia inducible factor 1 and the initial clinical presentation of coronary disease.

VEGFC THBS1

2.79e-05648218035072
Pubmed

Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

ROBO4 THBS1 VTN CPN2 F5

2.80e-0525748516335952
Pubmed

Sox9 in mouse urogenital sinus epithelium mediates elongation of prostatic buds and expression of genes involved in epithelial cell migration.

THBS1 SBSPON

2.21e-041648231669249
Pubmed

Proteomics characterization of extracellular space components in the human aorta.

THBS1 VTN SBSPON

3.74e-0410148320551380
Pubmed

Fulfilling the promise of personalized medicine? Systematic review and field synopsis of pharmacogenetic studies.

ETV6 F5 CES2

4.55e-0410848319956635
Pubmed

Signal peptide prediction based on analysis of experimentally verified cleavage sites.

VEGFC LRRC55 IL22RA2 ATRAID

4.86e-0426448415340161
Pubmed

Phosphoproteomic analysis of the human pituitary.

VTN PDPK1

6.40e-042748216807684
Pubmed

Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis.

THBS1 F5

1.02e-033448212878157
Pubmed

Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins.

THBS1 VTN SBSPON

1.09e-0314648327068509
Pubmed

Fog2 is critical for cardiac function and maintenance of coronary vasculature in the adult mouse heart.

VEGFC THBS1

1.14e-033648219411759
Pubmed

Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach.

THBS1 F5

1.27e-033848216263699
CytobandEnsembl 112 genes in cytogenetic band chr9q12

SPATA31A5 SPATA31A7

2.99e-058482chr9q12
Cytoband9p13.1

SPATA31A1 SPATA31A3

2.91e-04244829p13.1
GeneFamilyETS transcription factor family

ETV6 ETV7

6.79e-0428252534
CoexpressionNABA_ECM_GLYCOPROTEINS

KCP THBS1 VTN SSPOP SBSPON

2.33e-05191475MM17059
CoexpressionNABA_ECM_GLYCOPROTEINS

KCP THBS1 VTN SSPOP SBSPON

2.64e-05196475M3008
ToppCellMesenchymal_cells-Stromal_fibro.|Mesenchymal_cells / Lineage and Cell class

THBS1 VTN IL22RA2 TENM2 SBSPON

1.48e-06181485f8d914fdc06aaa75a4dc9158daf574ca28fa5432
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)-myeloid-myeloid_dendritic-liver_dendritic_cell|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

ETV6 VTN IL22RA2 CPN2

2.40e-05156484411c170a7dd65269ae442b8069caf5231bddb116
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SERINC5 F5 TENM2 SBSPON

3.36e-0517048460bbd738c12e64e483485586c30057304884f5a6
ToppCellMild-CD4+_T_Exhausted|Mild / Disease group and Cell class

SERINC5 OLFM2 F5 ESYT1

3.76e-051754846df099f37875f2cd63502b732a2e07ebfec50e47
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SERINC5 F5 TENM2 SBSPON

3.94e-051774844d2cdb57b427a42085c5f9affa0967b15e84dec3
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SERINC5 F5 TENM2 SBSPON

4.02e-05178484edc7143dc9959d36057cb9471681a23afcbc8cce
ToppCellCOVID-19-kidney-Podocyte|kidney / Disease (COVID-19 only), tissue and cell type

SERINC5 F5 TENM2 SBSPON

4.48e-05183484fb5e2a31b560126e1c04a386c24c365901c60ad7
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SERINC5 F5 TENM2 SBSPON

4.67e-05185484b848b63aff4d9dbb9e66a85876d4c7c6dacd0579
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SERINC5 F5 TENM2 SBSPON

4.67e-051854849197f074e769d54031ec41abfc65fcc0c6552c7e
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SERINC5 F5 TENM2 SBSPON

4.67e-05185484ce7d62394b09c26ca65b8cdb280afec5e25bbb62
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Degenerative_Podocyte|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SERINC5 F5 TENM2 SBSPON

4.98e-051884849db778c1d9e622a68337212296e3a1ed8f771fa5
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SERINC5 F5 TENM2 SBSPON

4.98e-05188484047c4e0b03fc8334e38c48977e41d26dbe229d47
ToppCell5'-Adult-Distal_Rectal-Endothelial-blood_vessel_EC-Mature_venous_EC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

VEGFC HIPK3 ROBO4 THBS1

5.40e-05192484eafead22bba48ac5ee568faa8946c444445c1034
ToppCellMesenchymal_cells-Stromal_fibro.|World / Lineage and Cell class

THBS1 VTN TENM2 SBSPON

5.73e-0519548469723b06c2a5c2aaf4d10874b11bca7f06822bdc
Diseaselevel of carboxypeptidase N subunit 2 in blood serum

VTN CPN2

2.17e-055442OBA_2041122
Diseasetorsin-1A-interacting protein 1 measurement

VTN F5

3.25e-056442EFO_0802137
Diseasesolute carrier family 22 member 16 measurement

MALRD1 F5

3.25e-056442EFO_0802079
Diseaseperipheral vascular disease

HIPK3 F5

4.54e-057442EFO_0003875
Diseasetriglyceride measurement, high density lipoprotein cholesterol measurement

PCSK7 TDRD15 VTN MALRD1 NEIL2

5.38e-05274445EFO_0004530, EFO_0004612
DiseaseE3 ubiquitin-protein ligase RNF13 measurement

VTN F5

6.05e-058442EFO_0801556
Diseasetyrosine-protein kinase JAK2 measurement

VTN CPN2

6.05e-058442EFO_0020825
Diseasefactor VII activating protease measurement

TSPYL5 MALRD1 ST8SIA3

7.69e-0555443EFO_0009368
Diseasephospholipid measurement, high density lipoprotein cholesterol measurement

PCSK7 TDRD15 VTN NEIL2 CES2

1.13e-04321445EFO_0004612, EFO_0004639
Disease3-hydroxyanthranilate 3,4-dioxygenase measurement

VTN CPN2

1.19e-0411442EFO_0021862
Diseaseinterleukin-22 receptor subunit alpha-2 measurement

VTN IL22RA2

1.19e-0411442EFO_0020500
DiseaseT-cell surface glycoprotein CD3 epsilon chain measurement

VTN F5

1.68e-0413442EFO_0802114
Diseasethrombosis (is_implicated_in)

VTN F5

2.25e-0415442DOID:0060903 (is_implicated_in)
Diseasecholesteryl esters:total lipids ratio, high density lipoprotein cholesterol measurement

PCSK7 TDRD15 VTN CES2

4.70e-04243444EFO_0004612, EFO_0020944
DiseaseLiver Cirrhosis

THBS1 VTN F5

4.93e-04103443C0023890
DiseaseFibrosis, Liver

THBS1 VTN F5

5.22e-04105443C0239946
Diseaseaggressive behavior

HIPK3 HERPUD2

6.38e-0425442EFO_0003015
DiseaseAlzheimer disease

USP50 SERINC5 TENM2 UNC5CL TNRC6A

7.53e-04485445MONDO_0004975
DiseasePolyarthritis, Juvenile, Rheumatoid Factor Positive

ETV6 THBS1 HERPUD2

9.91e-04131443C4704862
DiseasePolyarthritis, Juvenile, Rheumatoid Factor Negative

ETV6 THBS1 HERPUD2

9.91e-04131443C4552091
DiseaseJuvenile arthritis

ETV6 THBS1 HERPUD2

9.91e-04131443C3495559
DiseaseJuvenile psoriatic arthritis

ETV6 THBS1 HERPUD2

9.91e-04131443C3714758
DiseaseJuvenile-Onset Still Disease

ETV6 THBS1 HERPUD2

1.08e-03135443C0087031
Diseasefree cholesterol measurement, high density lipoprotein cholesterol measurement

PCSK7 TDRD15 VTN CES2

1.24e-03315444EFO_0004612, EFO_0008591
Diseaselipid measurement, high density lipoprotein cholesterol measurement

PCSK7 TDRD15 VTN CES2

1.47e-03330444EFO_0004529, EFO_0004612
Diseasevenous thromboembolism, factor VII measurement

XXYLT1 F5

1.48e-0338442EFO_0004286, EFO_0004619
Diseaselow density lipoprotein cholesterol measurement, phospholipids:total lipids ratio

PCSK7 TDRD15 CES2

1.55e-03153443EFO_0004611, EFO_0020946
Diseaselow density lipoprotein cholesterol measurement, cholesteryl esters:total lipids ratio

PCSK7 TDRD15 CES2

1.55e-03153443EFO_0004611, EFO_0020944
DiseaseC-reactive protein measurement

LRRC55 KCP ETV6 TDRD15 ST8SIA3 SSPOP NAGLU

1.91e-031206447EFO_0004458
Diseasediabetic retinopathy (biomarker_via_orthology)

THBS1 VTN

2.07e-0345442DOID:8947 (biomarker_via_orthology)
DiseaseTourette syndrome

TSPYL5 TENM2

2.54e-0350442EFO_0004895

Protein segments in the cluster

PeptideGeneStartEntry
DWFPLQGGQGQVHLR

ESYT1

431

Q9BSJ8
NLFNLALHGNPWQCD

CPN2

386

P22792
VQQNHPGWTVAGQFQ

APOL4

16

Q9BPW4
VWLLQGWLFQHQPQF

NAGLU

346

P54802
HQPQFWGPAQIRAVL

NAGLU

356

P54802
QAAYRNLGQNLWGPH

RCC2

126

Q9P258
NFIQHLLPQPWAGTG

OLFM2

256

O95897
VDPNGLARLWGNHKN

ETV6

371

P41212
EPQLWAGDNQGLLHV

FBXW9

356

Q5XUX1
HNPWLRRVHPQAFQG

LRRC55

146

Q6ZSA7
WLQGKFQGRPQHTQV

NEIL2

271

Q969S2
QHGFGLLNAWRLVNA

PCSK7

461

Q16549
RWVQQNIAHFGGNPD

CES2

206

O00748
FQSRNFHNILQWQPG

IL22RA2

36

Q969J5
FHNILQWQPGRALTG

IL22RA2

41

Q969J5
GNLLWYGHQDSPQVR

HAUS5

61

O94927
ALHIFWNFPGIFGNQ

IPO5

151

O00410
SIFHRIVQNGWIQGG

PPIL6

196

Q8IXY8
QAHVQAPQIGAWRNR

HIPK3

101

Q9H422
QPNWITLGNQLDGIH

METTL3

541

Q86U44
FGNQGNRWIRKHLNI

MALRD1

976

Q5VYJ5
GHGQPLNWISLEQNG

FUCA2

426

Q9BTY2
VDPNGLARLWGNHKN

ETV7

256

Q9Y603
FPQPRKQNWFLGHLG

CYP4F8

51

P98187
QAGWFPFRQEGGHQQ

HERPUD2

316

Q9BSE4
RILWGNNHFFRLNLP

KIF13B

531

Q9NQT8
PLAGAVGQLWSQHQR

SSPOP

176

A2VEC9
RNGQWHRGILQQLLP

TDRD15

301

B5MCY1
ENGNKQHQLGVWPLL

F5

1851

P12259
HAQPGLQVLWDGQSQ

KCP

1316

Q6ZWJ8
RLLLEKQAGGNPWHQ

PDPK1

436

O15530
CNNEQWGLRHPQILH

SPATA31A7

1296

Q8IWB4
EHRGQLKVQLAWPGN

ST8SIA3

266

O43173
GLNWQLQPADGHTFN

TENM2

401

Q9NT68
PAENHNGIIRGYQVW

ROBO4

371

Q8WZ75
QHVNCPGGINAWNTI

ATRAID

126

Q6UW56
CNNEQWGLRHPQILH

SPATA31A3

1296

Q5VYP0
LRNALWHTGNTPGQV

THBS1

1076

P07996
RKGGWQHNREQANLN

VEGFC

86

P49767
GNQTLHWQAIGNPRC

SBSPON

226

Q8IVN8
CNNEQWGLRHPQILH

SPATA31A1

1296

Q5TZJ5
CNNEQWGLRHPQILH

SPATA31A5

1296

Q5VU36
WVQNRQPHSGLLQSG

SERINC5

251

Q86VE9
ALQWALTNEQPHGGR

UNC5CL

276

Q8IV45
NQPHFQGVTGLWNLG

USP50

36

Q70EL3
LNQTGVQWAHRPDLG

PIGG

671

Q5H8A4
QPQFISRDWHGVPGQ

VTN

331

P04004
NHGAWPVLENNGLAL

TNRC6A

366

Q8NDV7
WQFRHENPQTRVGGP

XXYLT1

266

Q8NBI6
RNHLIQNIPGFWGQA

TSPYL5

241

Q86VY4