Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ABC-type sterol transporter activity	ABCG4 ABCG1	2.33e-06	2	31	2	GO:0034041
GeneOntologyMolecularFunction	transcription corepressor activity	RCOR3 SSX8P MTA1 MTA3 RCOR2	2.53e-05	229	31	5	GO:0003714
GeneOntologyMolecularFunction	ATPase-coupled lipid transmembrane transporter activity	ABCG4 ABCG1	8.34e-05	9	31	2	GO:0034040
GeneOntologyBiologicalProcess	cellular response to high density lipoprotein particle stimulus	ABCG4 ABCG1	1.40e-05	4	32	2	GO:0071403
GeneOntologyCellularComponent	histone deacetylase complex	RCOR3 MTA1 MTA3 RCOR2	9.52e-06	85	33	4	GO:0000118
GeneOntologyCellularComponent	NuRD complex	MTA1 MTA3	3.24e-04	17	33	2	GO:0016581
GeneOntologyCellularComponent	CHD-type complex	MTA1 MTA3	3.24e-04	17	33	2	GO:0090545
Domain	ELM2	RCOR3 MTA1 MTA3 RCOR2	4.39e-09	13	31	4	SM01189
Domain	ELM2	RCOR3 MTA1 MTA3 RCOR2	4.39e-09	13	31	4	PF01448
Domain	ELM2	RCOR3 MTA1 MTA3 RCOR2	4.39e-09	13	31	4	PS51156
Domain	ELM2_dom	RCOR3 MTA1 MTA3 RCOR2	4.39e-09	13	31	4	IPR000949
Domain	SANT_dom	RCOR3 MTA1 MTA3 RCOR2	9.05e-08	26	31	4	IPR017884
Domain	SANT	RCOR3 MTA1 MTA3 RCOR2	1.24e-07	28	31	4	PS51293
Domain	Myb_DNA-binding	RCOR3 MTA1 MTA3 RCOR2	3.14e-07	35	31	4	PF00249
Domain	MYB_LIKE	RCOR3 MTA1 MTA3 RCOR2	4.41e-07	38	31	4	PS50090
Domain	SANT	RCOR3 MTA1 MTA3 RCOR2	1.36e-06	50	31	4	SM00717
Domain	SANT/Myb	RCOR3 MTA1 MTA3 RCOR2	1.59e-06	52	31	4	IPR001005
Domain	ABCG1	ABCG4 ABCG1	2.67e-06	2	31	2	IPR020064
Domain	ABC_2_trans	ABCG4 ABCG1	2.66e-05	5	31	2	IPR013525
Domain	ABC2_membrane	ABCG4 ABCG1	2.66e-05	5	31	2	PF01061
Domain	BAH	MTA1 MTA3	1.45e-04	11	31	2	SM00439
Domain	BAH	MTA1 MTA3	1.45e-04	11	31	2	PF01426
Domain	BAH_dom	MTA1 MTA3	1.45e-04	11	31	2	IPR001025
Domain	BAH	MTA1 MTA3	1.45e-04	11	31	2	PS51038
Domain	ZnF_GATA	MTA1 MTA3	1.74e-04	12	31	2	SM00401
Domain	Znf_GATA	MTA1 MTA3	2.76e-04	15	31	2	IPR000679
Domain	GATA	MTA1 MTA3	2.76e-04	15	31	2	PF00320
Domain	GATA_ZN_FINGER_1	MTA1 MTA3	3.15e-04	16	31	2	PS00344
Domain	GATA_ZN_FINGER_2	MTA1 MTA3	3.15e-04	16	31	2	PS50114
Domain	Homeodomain-like	RCOR3 MTA1 MTA3 RCOR2	2.11e-03	332	31	4	IPR009057
Domain	ABC_transporter_CS	ABCG4 ABCG1	2.20e-03	42	31	2	IPR017871
Domain	ABC_TRANSPORTER_2	ABCG4 ABCG1	2.87e-03	48	31	2	PS50893
Domain	ABC_tran	ABCG4 ABCG1	2.87e-03	48	31	2	PF00005
Domain	HEAT	UTP20 NCAPD3	2.87e-03	48	31	2	PF02985
Domain	ABC_TRANSPORTER_1	ABCG4 ABCG1	2.99e-03	49	31	2	PS00211
Domain	ABC_transporter-like	ABCG4 ABCG1	3.11e-03	50	31	2	IPR003439
Domain	HEAT	UTP20 NCAPD3	4.16e-03	58	31	2	IPR000357
Domain	EGF_extracell	TENM4 ITGB3	4.44e-03	60	31	2	IPR013111
Domain	EGF_2	TENM4 ITGB3	4.44e-03	60	31	2	PF07974
Domain	HEAT_REPEAT	UTP20 NCAPD3	6.00e-03	70	31	2	PS50077
Domain	IQ	MYH3 SCN9A	6.17e-03	71	31	2	PF00612
Domain	IQ	MYH3 SCN9A	7.96e-03	81	31	2	SM00015
Domain	IQ_motif_EF-hand-BS	MYH3 SCN9A	9.75e-03	90	31	2	IPR000048
Domain	IQ	MYH3 SCN9A	1.04e-02	93	31	2	PS50096
Pathway	REACTOME_REGULATION_OF_PTEN_GENE_TRANSCRIPTION	BMI1 MTA1 MTA3	9.70e-05	61	21	3	M27811
Pathway	REACTOME_ABC_TRANSPORTERS_IN_LIPID_HOMEOSTASIS	ABCG4 ABCG1	2.84e-04	17	21	2	MM14552
Pathway	BIOCARTA_MTA3_PATHWAY	MTA1 MTA3	3.19e-04	18	21	2	M225
Pathway	REACTOME_ABC_TRANSPORTERS_IN_LIPID_HOMEOSTASIS	ABCG4 ABCG1	3.19e-04	18	21	2	M524
Pathway	BIOCARTA_MTA3_PATHWAY	MTA1 MTA3	3.95e-04	20	21	2	MM1383
Pathway	WP_EFFECT_OF_OMEGA3_PUFA_ON_HUNTINGTONS_DISEASE_PATHWAYS	ABCG4 ABCG1 GABRA4	6.98e-04	119	21	3	M48309
Pathway	REACTOME_REGULATION_OF_PTEN_GENE_TRANSCRIPTION	MTA1 MTA3	7.25e-04	27	21	2	MM15537
Pathway	REACTOME_TRANSCRIPTIONAL_REGULATION_OF_BROWN_AND_BEIGE_ADIPOCYTE_DIFFERENTIATION	MTA1 MTA3	9.58e-04	31	21	2	M48258
Pathway	REACTOME_INTRACELLULAR_SIGNALING_BY_SECOND_MESSENGERS	BMI1 MTA1 MTA3 ITPR2	1.06e-03	313	21	4	M27867
Pathway	REACTOME_PTEN_REGULATION	BMI1 MTA1 MTA3	1.10e-03	139	21	3	M27646
Pubmed	Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes.	RCOR3 MTA1 MTA3 RCOR2	9.73e-08	45	33	4	21258344
Pubmed	ZMYM3 regulates BRCA1 localization at damaged chromatin to promote DNA repair.	BMI1 RCOR3 MTA1 MTA3 RCOR2	3.00e-07	150	33	5	28242625
Pubmed	Functional expression and characterization of the human ABCG1 and ABCG4 proteins: indications for heterodimerization.	ABCG4 ABCG1	8.73e-07	2	33	2	15240127
Pubmed	Function and regulation of MTA1 and MTA3 in malignancies of the female reproductive system.	MTA1 MTA3	8.73e-07	2	33	2	25319202
Pubmed	Functional Cooperativity between ABCG4 and ABCG1 Isoforms.	ABCG4 ABCG1	8.73e-07	2	33	2	27228027
Pubmed	The metastasis-associated genes MTA1 and MTA3 are abundantly expressed in human placenta and chorionic carcinoma cells.	MTA1 MTA3	8.73e-07	2	33	2	19363681
Pubmed	LXR-induced redistribution of ABCG1 to plasma membrane in macrophages enhances cholesterol mass efflux to HDL.	ABCG4 ABCG1	8.73e-07	2	33	2	16556852
Pubmed	ATP-binding cassette transporters G1 and G4 mediate cholesterol and desmosterol efflux to HDL and regulate sterol accumulation in the brain.	ABCG4 ABCG1	8.73e-07	2	33	2	18039927
Pubmed	Identification and characterization of metastasis-associated gene/protein 1 (MTA1).	MTA1 MTA3	2.62e-06	3	33	2	25315816
Pubmed	ABCG1 and ABCG4 Suppress γ-Secretase Activity and Amyloid β Production.	ABCG4 ABCG1	2.62e-06	3	33	2	27196068
Pubmed	Structure, expression and functions of MTA genes.	MTA1 MTA3	2.62e-06	3	33	2	26869315
Pubmed	ABCA1 and ABCG1 or ABCG4 act sequentially to remove cellular cholesterol and generate cholesterol-rich HDL.	ABCG4 ABCG1	2.62e-06	3	33	2	16902247
Pubmed	ABCA1, ABCG1, and ABCG4 are distributed to distinct membrane meso-domains and disturb detergent-resistant domains on the plasma membrane.	ABCG4 ABCG1	2.62e-06	3	33	2	25302608
Pubmed	ABCG1 and ABCG4 are coexpressed in neurons and astrocytes of the CNS and regulate cholesterol homeostasis through SREBP-2.	ABCG4 ABCG1	2.62e-06	3	33	2	17916878
Pubmed	The Adaptor Protein Alix is Involved in the Interaction Between the Ubiquitin Ligase NEDD4-1 and its Targets, ABCG1 and ABCG4.	ABCG4 ABCG1	5.23e-06	4	33	2	31159502
Pubmed	ATP-binding cassette transporters G1 and G4 mediate cellular cholesterol efflux to high-density lipoproteins.	ABCG4 ABCG1	5.23e-06	4	33	2	15210959
Pubmed	Breast cancer risk associated with genotypic polymorphism of the genes involved in the estrogen-receptor-signaling pathway: a multigenic study on cancer susceptibility.	MTA1 MTA3	8.72e-06	5	33	2	16502042
Pubmed	The Nucleosome Remodelling and Deacetylation complex suppresses transcriptional noise during lineage commitment.	MTA1 MTA3	8.72e-06	5	33	2	31036553
Pubmed	Cholesterol efflux in megakaryocyte progenitors suppresses platelet production and thrombocytosis.	ABCG4 ABCG1	8.72e-06	5	33	2	23584088
Pubmed	Expression and functional characterization of ABCG1 splice variant ABCG1(666).	ABCG4 ABCG1	8.72e-06	5	33	2	16870176
Pubmed	Differential expression and subcellular distribution of the mouse metastasis-associated proteins Mta1 and Mta3.	MTA1 MTA3	8.72e-06	5	33	2	11483358
Pubmed	Antagonistic actions of Rcor proteins regulate LSD1 activity and cellular differentiation.	RCOR3 RCOR2	1.31e-05	6	33	2	24843136
Pubmed	A two-stage genome-wide association study of sporadic amyotrophic lateral sclerosis.	DPP6 ITPR2	1.31e-05	6	33	2	19193627
Pubmed	Corepressor Rcor1 is essential for murine erythropoiesis.	RCOR3 RCOR2	1.31e-05	6	33	2	24652990
Pubmed	The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6→ Tbr2→ Tbr1.	BMI1 MTA1 MTA3 RCOR2	1.48e-05	157	33	4	30186101
Pubmed	Epigenetic regulation of hematopoietic differentiation by Gfi-1 and Gfi-1b is mediated by the cofactors CoREST and LSD1.	RCOR3 RCOR2	2.44e-05	8	33	2	17707228
Pubmed	The zinc finger and C-terminal domains of MTA proteins are required for FOG-2-mediated transcriptional repression via the NuRD complex.	MTA1 MTA3	2.44e-05	8	33	2	18067919
Pubmed	RBB, a novel transcription repressor, represses the transcription of HDM2 oncogene.	MTA1 MTA3	3.13e-05	9	33	2	22926524
Pubmed	Dysfunction of the Reciprocal Feedback Loop between GATA3- and ZEB2-Nucleated Repression Programs Contributes to Breast Cancer Metastasis.	MTA1 MTA3	3.13e-05	9	33	2	26028330
Pubmed	PWWP2B Fine-Tunes Adipose Thermogenesis by Stabilizing HDACs in a NuRD Subcomplex.	MTA1 MTA3	3.91e-05	10	33	2	34180153
Pubmed	NuRD suppresses pluripotency gene expression to promote transcriptional heterogeneity and lineage commitment.	MTA1 MTA3	5.73e-05	12	33	2	22560079
Pubmed	Metastasis tumor antigen 2 (MTA2) is involved in proper imprinted expression of H19 and Peg3 during mouse preimplantation development.	MTA1 MTA3	5.73e-05	12	33	2	20720167
Pubmed	LSD1 is a subunit of the NuRD complex and targets the metastasis programs in breast cancer.	MTA1 MTA3	6.77e-05	13	33	2	19703393
Pubmed	Optimising experimental design for high-throughput phenotyping in mice: a case study.	MTA1 MTA3	6.77e-05	13	33	2	20799038
Pubmed	The metastasis-associated proteins 1 and 2 form distinct protein complexes with histone deacetylase activity.	MTA1 MTA3	6.77e-05	13	33	2	12920132
Pubmed	MBD2/NuRD and MBD3/NuRD, two distinct complexes with different biochemical and functional properties.	MTA1 MTA3	7.89e-05	14	33	2	16428440
Pubmed	NuRD-ZNF827 recruitment to telomeres creates a molecular scaffold for homologous recombination.	MTA1 MTA3	7.89e-05	14	33	2	25150861
Pubmed	An expanded Oct4 interaction network: implications for stem cell biology, development, and disease.	MTA1 MTA3 RCOR2	8.93e-05	91	33	3	20362542
Pubmed	NuRD mediates activating and repressive functions of GATA-1 and FOG-1 during blood development.	MTA1 MTA3	9.10e-05	15	33	2	19927129
Pubmed	The chromatin remodeling factor CHD5 is a transcriptional repressor of WEE1.	MTA1 MTA3	9.10e-05	15	33	2	25247294
Pubmed	A High-Density Map for Navigating the Human Polycomb Complexome.	BMI1 RCOR3 MTA1 MTA3 OGA	9.78e-05	495	33	5	27705803
Pubmed	Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham Study.	NCAPD3 TENM4	1.04e-04	16	33	2	17903297
Pubmed	Mi-2/NuRD is required in renal progenitor cells during embryonic kidney development.	MTA1 MTA3	1.32e-04	18	33	2	23201013
Pubmed	Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation.	MTA1 MTA3	1.32e-04	18	33	2	10444591
Pubmed	The dermatomyositis-specific autoantigen Mi2 is a component of a complex containing histone deacetylase and nucleosome remodeling activities.	MTA1 MTA3	1.32e-04	18	33	2	9790534
Pubmed	Direct binding of CoREST1 to SUMO-2/3 contributes to gene-specific repression by the LSD1/CoREST1/HDAC complex.	RCOR3 MTA1 RCOR2	1.40e-04	106	33	3	19394292
Pubmed	SOCS2 Binds to and Regulates EphA2 through Multiple Mechanisms.	NCAPD3 RCOR3 OGA	1.57e-04	110	33	3	28883622
Pubmed	The functional interactome landscape of the human histone deacetylase family.	RCOR3 MTA1 MTA3 RCOR2	1.58e-04	289	33	4	23752268
Pubmed	FOXK2 Elicits Massive Transcription Repression and Suppresses the Hypoxic Response and Breast Cancer Carcinogenesis.	MTA1 MTA3	1.64e-04	20	33	2	27773593
Pubmed	Differential expression and function of ABCG1 and ABCG4 during development and aging.	ABCG4 ABCG1	1.99e-04	22	33	2	19633360
Pubmed	Oncogenic RAS directs silencing of tumor suppressor genes through ordered recruitment of transcriptional repressors.	BMI1 RCOR2	3.49e-04	29	33	2	24105743
Pubmed	A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal.	MTA1 MTA3 RCOR2	3.61e-04	146	33	3	23892456
Pubmed	PHD finger protein 1 (PHF1) is a novel reader for histone H4R3 symmetric dimethylation and coordinates with PRMT5-WDR77/CRL4B complex to promote tumorigenesis.	MTA1 MTA3	3.99e-04	31	33	2	29846670
Pubmed	Systematic identification of factors for provirus silencing in embryonic stem cells.	MTA1 MTA3 RCOR2	4.13e-04	153	33	3	26365490
Pubmed	HOXA5 Participates in Brown Adipose Tissue and Epaxial Skeletal Muscle Patterning and in Brown Adipocyte Differentiation.	MYH3 ELOVL6	4.25e-04	32	33	2	33732701
Pubmed	A high-resolution radiation hybrid map of the proximal portion of mouse chromosome 5.	DPP6 GABRA4	4.53e-04	33	33	2	10843805
Pubmed	The E3 ubiquitin ligases, HUWE1 and NEDD4-1, are involved in the post-translational regulation of the ABCG1 and ABCG4 lipid transporters.	ABCG4 ABCG1	4.53e-04	33	33	2	26296893
Pubmed	Gfi1b regulates the level of Wnt/β-catenin signaling in hematopoietic stem cells and megakaryocytes.	RCOR3 RCOR2	4.81e-04	34	33	2	30894540
Pubmed	Direct recruitment of polycomb repressive complex 1 to chromatin by core binding transcription factors.	BMI1 MTA1	5.09e-04	35	33	2	22325351
Pubmed	The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis.	BMI1 NCAPD3 MTA1 MTA3	5.22e-04	396	33	4	26687479
Pubmed	An Oct4-centered protein interaction network in embryonic stem cells.	MTA1 MTA3 RCOR2	5.34e-04	167	33	3	20362541
Pubmed	Effects of glucokinase haploinsufficiency on the pancreatic β-cell mass and function of long-term high-fat, high-sucrose diet-fed mice.	DPP6 GABRA4	5.69e-04	37	33	2	39305123
Pubmed	Cross-linking mass spectrometry reveals the structural topology of peripheral NuRD subunits relative to the core complex.	MTA1 MTA3	6.01e-04	38	33	2	33283408
Pubmed	Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells.	RCOR3 MTA3 RCOR2	6.32e-04	177	33	3	26206133
Cytoband	7p22.1	RSPH10B2 RSPH10B	5.31e-04	47	33	2	7p22.1
Cytoband	Ensembl 112 genes in cytogenetic band chr7p22	RSPH10B2 RSPH10B	4.21e-03	134	33	2	chr7p22
GeneFamily	GATA zinc finger domain containing\|Myb/SANT domain containing	RCOR3 MTA1 MTA3 RCOR2	4.63e-07	53	22	4	532
GeneFamily	Blood group antigens\|CD molecules\|ATP binding cassette subfamily G	ABCG4 ABCG1	1.41e-05	5	22	2	811
GeneFamily	PHD finger proteins\|NuRD complex	MTA1 MTA3	9.26e-05	12	22	2	1305
GeneFamily	GATA zinc finger domain containing\|Myb/SANT domain containing	MTA1 MTA3	1.47e-04	15	22	2	82
ToppCell	RA-11._Adipocyte\|RA / Chamber and Cluster_Paper	TENM4 ELOVL6 OGA F3 ITPR2	2.10e-07	180	33	5	d48a3d27357f7d184132a6805950f93080146b59
ToppCell	RA-11._Adipocyte\|World / Chamber and Cluster_Paper	TENM4 ELOVL6 OGA F3 ITPR2	2.61e-07	188	33	5	4dac9d636e5cad4cda540b93d4bfed6b5732c880
ToppCell	LA-11._Adipocyte\|World / Chamber and Cluster_Paper	TENM4 ELOVL6 OGA F3	9.88e-06	183	33	4	b177be283e1553fb1f69a346f1ba79ad00297fa2
Disease	glycine measurement	ENPP6 TENM4 SLC44A5	4.00e-04	137	31	3	EFO_0009767
Disease	Mental deterioration	TENM4 GABRA4	4.26e-04	29	31	2	HP_0001268
Disease	attention deficit hyperactivity disorder	DPP6 TENM4 ELOVL6 MTA3	4.96e-04	354	31	4	EFO_0003888
Disease	amyotrophic lateral sclerosis (is_implicated_in)	DPP6 ITPR2	5.20e-04	32	31	2	DOID:332 (is_implicated_in)
Disease	diabetic retinopathy (is_marker_for)	F3 ITGB3	1.48e-03	54	31	2	DOID:8947 (is_marker_for)
Disease	Alzheimer's disease (implicated_via_orthology)	RCOR3 RCOR2	1.64e-03	57	31	2	DOID:10652 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
TVEEKYPYMVEWYTK	NT5C3A	141	Q9H0P0
WYSLKAYYLAKTMAD	ABCG4	461	Q9H172
YWYSLKAYYLAKTMA	ABCG1	491	P45844
YGSYLYKLRTKWMLQ	DPPA5	71	A6NC42
KYYYSWKKTRSRTSV	RCOR2	171	Q8IZ40
ASLVKYYYSWKKTRS	RCOR3	121	Q9P2K3
YYYSWKKTRSRTSLM	RCOR3	126	Q9P2K3
TSWKITLFMKYSSYR	ITPR2	216	Q14571
TLYSMSYMNKCWEIY	RSPH10B	546	P0C881
TLYSMSYMNKCWEIY	RSPH10B2	546	B2RC85
KDYYTLMDIAYIYTW	BMI1	201	P35226
VYWVVYLSKDTMEKS	GABRA4	536	P48169
WYYITFETVKKFYTI	HFM1	786	A2PYH4
QYIWSYYSVAELKKM	KCTD18	196	Q6PI47
ITVLLYSWYSYKDMV	ELOVL6	146	Q9H5J4
SFYEYLIKSWLMSGK	MAN1C1	391	Q9NR34
YYLMDLSYSMKDDLW	ITGB3	141	P05106
MQLLYTKDKSYWEDY	SLC44A5	131	Q8NCS7
YYITMVKWATSTKVA	DPP6	381	P42658
TLTKAKRKVYMYYWP	ENPP6	126	Q6UWR7
KSLTSIIEYYYMWKT	MTA3	301	Q9BTC8
IIEYYYMWKTTDRYV	MTA3	306	Q9BTC8
SLSYLYKYLWRLMVK	UTP20	151	O75691
ILYDMYSYVWDIKSI	OGA	636	O60502
YSYVWDIKSIMSMVK	OGA	641	O60502
MLLKWIAYGYKTYFT	SCN9A	1241	Q15858
LKDRYTSWMIYTYSG	MYH3	106	P11055
TSIIEYYYMWKTTDR	MTA1	321	Q13330
YYYMWKTTDRYVQQK	MTA1	326	Q13330
YFGSYLKSTKLWIIM	STK25	81	O00506
SYYIFWYKQLPSKEM	TRDV1	51	A0A1B0GX56
AMFIAWLYKYSRSSK	NCAPD3	391	P42695
IYPESYYWTTAQTMK	SLFN12L	536	Q6IEE8
EWEKMKYSEKISYVY	SSX8P	36	Q7RTT4
GKTWSYTYLEKSMVL	TENM4	1921	Q6N022
KDLIYTLYYWKSSSS	F3	181	P13726
KVKYYNVEYMKTTWF	MYOM3	1241	Q5VTT5