Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	RNA polymerase II core promoter sequence-specific DNA binding	TAF1 REST TAF1L	1.60e-04	25	85	3	GO:0000979
GeneOntologyMolecularFunction	H3K27me3 modified histone binding	TAF1 TAF1L	1.78e-04	5	85	2	GO:0061628
GeneOntologyBiologicalProcess	positive regulation of organelle organization	PLXNA3 TPR CAMKK2 RESF1 CARMIL2 RAB3GAP2 KDR DYNC1H1 MFF SPAG5 HTT	2.61e-05	574	86	11	GO:0010638
GeneOntologyBiologicalProcess	olfactory nerve morphogenesis	PLXNA3 DMD	5.14e-05	3	86	2	GO:0021627
GeneOntologyBiologicalProcess	anatomical structure arrangement	PLXNA3 USP9X DMD	8.82e-05	21	86	3	GO:0048532
GeneOntologyBiologicalProcess	regulation of organelle organization	PLXNA3 TPR CAMKK2 EFNB1 RESF1 CARMIL2 PTPRD ARID2 RAB3GAP2 KDR ANKRD23 DYNC1H1 TUBG1 MFF SPAG5 HTT	1.20e-04	1342	86	16	GO:0033043
GeneOntologyBiologicalProcess	neuron projection morphogenesis	BOC PLXNA3 KIF13B EFNB1 PTPRD RAPH1 USP9X LRP2 KDR DMD PARD3 ADAM10	1.20e-04	802	86	12	GO:0048812
GeneOntologyBiologicalProcess	plasma membrane bounded cell projection morphogenesis	BOC PLXNA3 KIF13B EFNB1 PTPRD RAPH1 USP9X LRP2 KDR DMD PARD3 ADAM10	1.46e-04	819	86	12	GO:0120039
GeneOntologyBiologicalProcess	positive regulation of cellular component organization	PLXNA3 TPR CAMKK2 RESF1 CARMIL2 PTPRD FRMPD4 RAB3GAP2 LRP2 KDR DMD PARD3 DYNC1H1 MFF SPAG5 HTT	1.47e-04	1366	86	16	GO:0051130
GeneOntologyBiologicalProcess	cell division	TPR CENPT DIS3L2 HMCN1 USP9X AKNA PARD3 DYNC1H1 SPAG5 CDK4 SON	1.48e-04	697	86	11	GO:0051301
GeneOntologyBiologicalProcess	cell projection morphogenesis	BOC PLXNA3 KIF13B EFNB1 PTPRD RAPH1 USP9X LRP2 KDR DMD PARD3 ADAM10	1.58e-04	826	86	12	GO:0048858
GeneOntologyBiologicalProcess	regulation of organelle assembly	TPR EFNB1 PTPRD RAB3GAP2 DYNC1H1 SPAG5 HTT	1.70e-04	280	86	7	GO:1902115
GeneOntologyCellularComponent	transcription regulator complex	PER2 GTF3C2 FLYWCH1 HOXD10 ARID2 E2F5 TAF1 REST TAF1L CDK4	1.37e-04	596	84	10	GO:0005667
GeneOntologyCellularComponent	pronucleus	RIF1 TAF1 TAF1L	1.91e-04	28	84	3	GO:0045120
Domain	TAF_II_230-bd	TAF1 TAF1L	2.14e-05	2	87	2	IPR009067
Domain	TFIID_sub1_DUF3591	TAF1 TAF1L	2.14e-05	2	87	2	IPR022591
Domain	-	TAF1 TAF1L	2.14e-05	2	87	2	1.10.1100.10
Domain	TBP-binding	TAF1 TAF1L	2.14e-05	2	87	2	PF09247
Domain	DUF3591	TAF1 TAF1L	2.14e-05	2	87	2	PF12157
Domain	TAF1_animal	TAF1 TAF1L	2.14e-05	2	87	2	IPR011177
Domain	Znf_C2H2_matrin	CIZ1 ZNF318	1.37e-03	12	87	2	IPR000690
Domain	ARM-like	AP4E1 RIF1 USP9X ARID2 HTT ARMH4	1.64e-03	270	87	6	IPR011989
Domain	TIL_dom	LRP2 MUC5B	1.88e-03	14	87	2	IPR002919
Domain	Ig_I-set	BOC PTPRD HMCN1 OBSCN KDR	1.95e-03	190	87	5	IPR013098
Domain	ig	BOC PTPRD HMCN1 OBSCN KDR	1.95e-03	190	87	5	PF00047
Domain	Immunoglobulin	BOC PTPRD HMCN1 OBSCN KDR	1.95e-03	190	87	5	IPR013151
Domain	I-set	BOC PTPRD HMCN1 OBSCN KDR	1.95e-03	190	87	5	PF07679
Domain	ZF_MATRIN	CIZ1 ZNF318	3.13e-03	18	87	2	PS50171
Domain	TNFR_c6	TNFRSF9 TNFRSF10B	4.66e-03	22	87	2	PF00020
Domain	IGc2	BOC PTPRD HMCN1 OBSCN KDR	4.84e-03	235	87	5	SM00408
Domain	Ig_sub2	BOC PTPRD HMCN1 OBSCN KDR	4.84e-03	235	87	5	IPR003598
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	TPR GTF3C2 RAPH1 AMOT USP9X ARID2 RAB3GAP2 CIZ1 ZNF318 TAF1 PARD3 DYNC1H1 ZMYM4 HTT	1.12e-10	549	88	14	38280479
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	TPR RESF1 GTF3C2 RAPH1 AMOT RAB3GAP2 LRP2 ZNF318 TAF1 ZMYM4 SPAG5	9.26e-09	418	88	11	34709266
Pubmed	Tagging genes with cassette-exchange sites.	RIF1 ZFAT ENOX1 RESF1 USP9X REST CMSS1 ZMYM4 AQR	1.88e-07	335	88	9	15741177
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	KIF13B RIF1 PDE8A GTF3C2 AMOT GPS1 CIZ1 BCKDHA E2F5 PARD3 HDAC7 CLUH DYNC1H1 TUBG1 SPAG5 CDK4	1.89e-07	1321	88	16	27173435
Pubmed	Genetic mapping in the region of the mouse X-inactivation center.	TAF1 DMD TAF1L	8.69e-07	8	88	3	1974879
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	CAMKK2 FRMPD4 PER2 RAB3GAP2 OTUD4 DYNC1H1 AQR PCDHB16 SON	9.53e-07	407	88	9	12693553
Pubmed	Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation.	RIF1 RESF1 LRP2 ZNF318 DMD	1.06e-06	71	88	5	33541421
Pubmed	Genetic and molecular evidence of an X-chromosome deletion spanning the tabby (Ta) and testicular feminization (Tfm) loci in the mouse.	TAF1 DMD TAF1L	1.85e-06	10	88	3	2055107
Pubmed	Characterization of a murine gene expressed from the inactive X chromosome.	TAF1 DMD TAF1L	2.55e-06	11	88	3	2034278
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	TPR KIF13B FAM184B TNFRSF9 RESF1 FLYWCH1 AMOT OBSCN LRP2 OTUD4 ZNF318 PARD3 SPAG5	3.36e-06	1084	88	13	11544199
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	TPR RIF1 RAPH1 OTUD4 ZNF318 REST PARD3 HDAC7 CLUH ZMYM4 SON	4.17e-06	774	88	11	15302935
Pubmed	Rps4 maps near the inactivation center on the mouse X chromosome.	TAF1 DMD TAF1L	4.40e-06	13	88	3	1740345
Pubmed	Mapping of loci and translocation breakpoints in Xq13: isolation of a conserved locus that maps close to CCG1 in human and mouse.	TAF1 DMD TAF1L	4.40e-06	13	88	3	8012115
Pubmed	XIST and the mapping of the X chromosome inactivation centre.	TAF1 DMD TAF1L	4.40e-06	13	88	3	1772416
Pubmed	The murine interleukin-2 receptor gamma chain gene: organization, chromosomal localization and expression in the adult thymus.	TAF1 DMD TAF1L	4.40e-06	13	88	3	7805729
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	BOC ZFAT AMOT OBSCN TAF1 ANKRD23 PARD3 ZMYM4 SON	4.86e-06	497	88	9	23414517
Pubmed	Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	RESF1 FLYWCH1 ARID2 OBSCN PCDHB16	6.05e-06	101	88	5	10997877
Pubmed	KIF13B-mediated VEGFR2 trafficking is essential for vascular leakage and metastasis in vivo.	KIF13B KDR	6.33e-06	2	88	2	34670814
Pubmed	Disruption of peripheral circadian timekeeping in a mouse model of Huntington's disease and its restoration by temporally scheduled feeding.	PER2 HTT	6.33e-06	2	88	2	20668203
Pubmed	Structural and Functional Alterations of Skeletal Muscle Microvasculature in Dystrophin-Deficient mdx Mice.	KDR DMD	6.33e-06	2	88	2	26193666
Pubmed	KIF13B mediates VEGFR2 recycling to modulate vascular permeability.	KIF13B KDR	6.33e-06	2	88	2	36928770
Pubmed	Diagnostic significance of alternative splice variants of REST and DOPEY1 in the peripheral blood of patients with breast cancer.	REST DOP1A	6.33e-06	2	88	2	25424701
Pubmed	Taf1 knockout is lethal in embryonic male mice and heterozygous females show weight and movement disorders.	TAF1 TAF1L	6.33e-06	2	88	2	38804708
Pubmed	Sustained expression of a neuron-specific isoform of the Taf1 gene in development stages and aging in mice.	TAF1 TAF1L	6.33e-06	2	88	2	22842574
Pubmed	Frameshift Mutations in the Mononucleotide Repeats of TAF1 and TAF1L Genes in Gastric and Colorectal Cancers with Regional Heterogeneity.	TAF1 TAF1L	6.33e-06	2	88	2	27571988
Pubmed	Striatal Cholinergic Dysregulation after Neonatal Decrease in X-Linked Dystonia Parkinsonism-Related TAF1 Isoforms.	TAF1 TAF1L	6.33e-06	2	88	2	34403156
Pubmed	A zinc finger protein that represses transcription of the human MHC class II gene, DPA.	HLA-DPA1 REST	6.33e-06	2	88	2	8568247
Pubmed	Dysregulation of REST-regulated coding and non-coding RNAs in a cellular model of Huntington's disease.	REST HTT	6.33e-06	2	88	2	23145961
Pubmed	Deubiquitylating enzyme USP9x regulates hippo pathway activity by controlling angiomotin protein turnover.	AMOT USP9X	6.33e-06	2	88	2	27462448
Pubmed	KIF13B regulates angiogenesis through Golgi to plasma membrane trafficking of VEGFR2.	KIF13B KDR	6.33e-06	2	88	2	25128562
Pubmed	TAFII250, Egr-1, and D-type cyclin expression in mice and neonatal rat cardiomyocytes treated with doxorubicin.	TAF1 TAF1L	6.33e-06	2	88	2	10070062
Pubmed	Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes.	REST HTT	6.33e-06	2	88	2	12881722
Pubmed	Huntingtin regulates mammary stem cell division and differentiation.	PARD3 TUBG1 HTT	1.24e-05	18	88	3	24749073
Pubmed	Chromatin accessibility complex subunit 1 enhances tumor growth by regulating the oncogenic transcription of YAP in breast and cervical cancer.	TPR AMOT USP9X DYNC1H1	1.36e-05	57	88	4	38223760
Pubmed	The interaction between RE1-silencing transcription factor (REST) and heat shock protein 90 as new therapeutic target against Huntington's disease.	REST HTT	1.90e-05	3	88	2	31361762
Pubmed	Role of ADAM10 and ADAM17 in Regulating CD137 Function.	TNFRSF9 ADAM10	1.90e-05	3	88	2	33800462
Pubmed	Transcriptional activation of REST by Sp1 in Huntington's disease models.	REST HTT	1.90e-05	3	88	2	21179468
Pubmed	Regulated expression of TAF1 in 1-cell mouse embryos.	TAF1 TAF1L	1.90e-05	3	88	2	16822332
Pubmed	TAFII55 binding to TAFII250 inhibits its acetyltransferase activity.	TAF1 TAF1L	1.90e-05	3	88	2	11592977
Pubmed	Functional substitution for TAF(II)250 by a retroposed homolog that is expressed in human spermatogenesis.	TAF1 TAF1L	1.90e-05	3	88	2	12217962
Pubmed	TAF7: a possible transcription initiation check-point regulator.	TAF1 TAF1L	1.90e-05	3	88	2	16407123
Pubmed	Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.	TPR RIF1 GTF3C2 USP9X ARID2 TAF1 DYNC1H1	2.22e-05	332	88	7	32786267
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	RIF1 GTF3C2 FLYWCH1 ARID2 CIZ1 OTUD4 ZNF318 CMSS1 PARD3 TAF1L ZMYM4 MFF AQR SON	2.29e-05	1497	88	14	31527615
Pubmed	DIAPH3 deficiency links microtubules to mitotic errors, defective neurogenesis, and brain dysfunction.	PARD3 TUBG1 SPAG5	2.33e-05	22	88	3	33899739
Pubmed	Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.	FAM184B ZFAT DIS3L2 LTBP2 REST	2.56e-05	136	88	5	25429064
Pubmed	Systematic analysis of human protein complexes identifies chromosome segregation proteins.	TPR PER2 GTF3C2 ARID2 GPS1 CIZ1 TYMP DYNC1H1 ZMYM4 TUBG1 AQR SPAG5	3.42e-05	1155	88	12	20360068
Pubmed	Huntingtin Is Required for Epithelial Polarity through RAB11A-Mediated Apical Trafficking of PAR3-aPKC.	PARD3 HTT	3.79e-05	4	88	2	25942483
Pubmed	Huntingtin facilitates dynein/dynactin-mediated vesicle transport.	DYNC1H1 HTT	3.79e-05	4	88	2	17548833
Pubmed	Nuclear Mitotic Apparatus (NuMA) Interacts with and Regulates Astrin at the Mitotic Spindle.	DYNC1H1 SPAG5	3.79e-05	4	88	2	27462074
Pubmed	Polyglutamine expansion of huntingtin impairs its nuclear export.	TPR HTT	3.79e-05	4	88	2	15654337
Pubmed	VEGF-A stimulates ADAM17-dependent shedding of VEGFR2 and crosstalk between VEGFR2 and ERK signaling.	KDR ADAM10	3.79e-05	4	88	2	18818406
Pubmed	The epidermal polarity protein Par3 is a non-cell autonomous suppressor of malignant melanoma.	PARD3 CDK4	3.79e-05	4	88	2	28096290
Pubmed	Expression of the immunoglobulin superfamily cell adhesion molecules in the developing spinal cord and dorsal root ganglion.	BOC PTPRD HMCN1 OBSCN KDR	5.91e-05	162	88	5	25826454
Pubmed	Human transcription factor protein interaction networks.	RIF1 RESF1 GTF3C2 USP9X ARID2 LRP2 OTUD4 ZNF318 TAF1 SUFU TAF1L DYNC1H1 ZMYM4	6.15e-05	1429	88	13	35140242
Pubmed	Flt-1 haploinsufficiency ameliorates muscular dystrophy phenotype by developmentally increased vasculature in mdx mice.	KDR DMD	6.30e-05	5	88	2	20705734
Pubmed	mGluR5 regulates REST/NRSF signaling through N-cadherin/β-catenin complex in Huntington's disease.	REST HTT	6.30e-05	5	88	2	32859226
Pubmed	N-terminal cleavage and release of the ectodomain of Flt1 is mediated via ADAM10 and ADAM 17 and regulated by VEGFR2 and the Flt1 intracellular domain.	KDR ADAM10	6.30e-05	5	88	2	25387128
Pubmed	Acetylation at lysine 346 controls the transforming activity of the HTLV-1 Tax oncoprotein in the Rat-1 fibroblast model.	HDAC7 CDK4	6.30e-05	5	88	2	23880157
Pubmed	CSN5/JAB1 interacts with the centromeric components CENP-T and CENP-W and regulates their proteasome-mediated degradation.	CENPT GPS1	6.30e-05	5	88	2	23926101
Pubmed	The carboxyl terminus of B class ephrins constitutes a PDZ domain binding motif.	EFNB1 PARD3	6.30e-05	5	88	2	9920925
Pubmed	A two-kinesin mechanism controls neurogenesis in the developing brain.	KIF13B TUBG1	6.30e-05	5	88	2	38040957
Pubmed	Formation of the collateral circulation is regulated by vascular endothelial growth factor-A and a disintegrin and metalloprotease family members 10 and 17.	KDR ADAM10	6.30e-05	5	88	2	22965144
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	KIF13B RESF1 CARMIL2 RAPH1 AMOT RAB3GAP2 PARD3 HDAC7 AQR DOP1A	6.49e-05	861	88	10	36931259
Pubmed	Essential roles for the splicing regulator nSR100/SRRM4 during nervous system development.	TAF1 REST TAF1L	6.68e-05	31	88	3	25838543
Pubmed	A proteome-scale map of the SARS-CoV-2-human contactome.	AMOT USP9X PCDHB1 MFF SPAG5	8.07e-05	173	88	5	36217029
Pubmed	Large-scale mapping of human protein-protein interactions by mass spectrometry.	FAM120B USP9X RAB3GAP2 GPS1 OTUD4 BCKDHA PARD3 HDAC7 DYNC1H1 NACA4P CDK4 SON	9.40e-05	1284	88	12	17353931
Pubmed	Pathogenic huntingtin inhibits fast axonal transport by activating JNK3 and phosphorylating kinesin.	DYNC1H1 HTT	9.43e-05	6	88	2	19525941
Pubmed	Huntingtin regulates RE1-silencing transcription factor/neuron-restrictive silencer factor (REST/NRSF) nuclear trafficking indirectly through a complex with REST/NRSF-interacting LIM domain protein (RILP) and dynactin p150 Glued.	REST HTT	9.43e-05	6	88	2	18922795
Pubmed	Transforming growth factor-beta regulates basal transcriptional regulatory machinery to control cell proliferation and differentiation in cranial neural crest-derived osteoprogenitor cells.	TAF1 TAF1L	9.43e-05	6	88	2	19959467
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	RESF1 ARID2 CIZ1 LRP2 BCKDHA ZNF318 TAF1 TNFRSF10B PARD3 TUBG1 SON	1.18e-04	1116	88	11	31753913
Pubmed	Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family.	AMOT USP9X GPS1 BCKDHA DMD CMSS1 SUFU CLUH MFF CDK4	1.23e-04	931	88	10	27432908
Pubmed	Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.	TPR ZFAT DIS3L2 USP9X ARID2 RAB3GAP2 REST CRAMP1 ZMYM4 HTT GABPB1 CDK4	1.28e-04	1327	88	12	32694731
Pubmed	Nudel functions in membrane traffic mainly through association with Lis1 and cytoplasmic dynein.	DYNC1H1 TUBG1	1.32e-04	7	88	2	14970193
Pubmed	Roles of ephrinB ligands and EphB receptors in cardiovascular development: demarcation of arterial/venous domains, vascular morphogenesis, and sprouting angiogenesis.	EFNB1 KDR	1.32e-04	7	88	2	9990854
Pubmed	Spatial regulation of VEGF receptor endocytosis in angiogenesis.	KDR PARD3	1.32e-04	7	88	2	23354168
Pubmed	Noncanonical regulation of alkylation damage resistance by the OTUD4 deubiquitinase.	RIF1 USP9X OTUD4	1.34e-04	39	88	3	25944111
Pubmed	Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	AMOT OTUD4 DOP1A SON	1.45e-04	104	88	4	10470851
Pubmed	K48- and K63-linked ubiquitin chain interactome reveals branch- and length-specific ubiquitin interactors.	RIF1 FAM120B RAB3GAP2 OTUD4 CMSS1 PARD3 HDAC7 MFF	1.50e-04	604	88	8	38803224
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	TPR RIF1 CENPT ARID2 CIZ1 ZNF318 TAF1 TAF1L ZMYM4 SON	1.50e-04	954	88	10	36373674
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	RIF1 CENPT GTF3C2 FLYWCH1 ARID2 CIZ1 TAF1 ZMYM4	1.57e-04	608	88	8	36089195
Pubmed	Oct4 links multiple epigenetic pathways to the pluripotency network.	TPR RIF1 TAF1 TAF1L DYNC1H1	1.71e-04	203	88	5	22083510
Pubmed	Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons.	AP4E1 PTPRD RAB3GAP2 DMD DYNC1H1 MFF	1.72e-04	322	88	6	26514267
Pubmed	Novel obscurins mediate cardiomyocyte adhesion and size via the PI3K/AKT/mTOR signaling pathway.	OBSCN DMD	1.75e-04	8	88	2	28826662
Pubmed	ATAD3A oligomerization causes neurodegeneration by coupling mitochondrial fragmentation and bioenergetics defects.	MFF HTT	1.75e-04	8	88	2	30914652
Pubmed	High-density molecular map of the central span of the mouse X chromosome.	TAF1 TAF1L	1.75e-04	8	88	2	1675191
Pubmed	Conservation of position and exclusive expression of mouse Xist from the inactive X chromosome.	TAF1 TAF1L	1.75e-04	8	88	2	2034279
Pubmed	Physical mapping of 2000 kb of the mouse X chromosome in the vicinity of the Xist locus.	TAF1 TAF1L	1.75e-04	8	88	2	8468051
Pubmed	Deletion of Prl7d1 causes placental defects at mid-pregnancy in mice.	TAF1 TAF1L	1.75e-04	8	88	2	31012985
Pubmed	A protein interaction landscape of breast cancer.	TPR USP9X ARID2 GPS1 MUC5B CLUH SPAG5 CDK4	2.09e-04	634	88	8	34591612
Pubmed	The intracellular localisation of TAF7L, a paralogue of transcription factor TFIID subunit TAF7, is developmentally regulated during male germ-cell differentiation.	TAF1 TAF1L	2.25e-04	9	88	2	12665565
Pubmed	GLI activation by atypical protein kinase C ι/λ regulates the growth of basal cell carcinomas.	PARD3 TUBG1	2.25e-04	9	88	2	23446420
Pubmed	HIV-1 tat binds TAFII250 and represses TAFII250-dependent transcription of major histocompatibility class I genes.	TAF1 TAF1L	2.25e-04	9	88	2	9751712
Pubmed	Molecular characterization of ENU mouse mutagenesis and archives.	NCS1 HTT	2.25e-04	9	88	2	16139793
Pubmed	Cloning and characterization of a new human Xq13 gene, encoding a putative helicase.	TAF1 TAF1L	2.25e-04	9	88	2	7874112
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	TPR RIF1 USP9X ZNF318 CLUH DYNC1H1 AQR SON	2.54e-04	653	88	8	22586326
Pubmed	Distinct class of putative "non-conserved" promoters in humans: comparative studies of alternative promoters of human and mouse genes.	RESF1 LYSMD3 DYNC1H1	2.65e-04	49	88	3	17567985
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	TPR RIF1 EFNB1 AMOT USP9X CIZ1 ZNF318 DYNC1H1 AQR SON	2.65e-04	1024	88	10	24711643
Pubmed	Genome-wide association study of co-occurring anxiety in major depression.	PTPRD DMD	2.81e-04	10	88	2	24047446
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	TPR RIF1 GTF3C2 USP9X GPS1 OTUD4 SON	2.94e-04	503	88	7	16964243
Pubmed	Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing.	TPR RIF1 RAPH1 ZNF318 DYNC1H1 AQR SON	3.04e-04	506	88	7	30890647
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	BOC PTPRD HMCN1 OBSCN KDR	1.65e-04	161	58	5	593
GeneFamily	Endogenous ligands\|Minor histocompatibility antigens	RESF1 TYMP SON	5.85e-04	51	58	3	870
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPRD FRMPD4 HMCN1 OBSCN LRP2 MUC5B DMD	8.19e-08	184	88	7	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPRD FRMPD4 HMCN1 OBSCN LRP2 MUC5B DMD	8.19e-08	184	88	7	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPRD FRMPD4 HMCN1 OBSCN LRP2 MUC5B DMD	8.19e-08	184	88	7	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	Control-Neu_4\|World / 5 Neutrophil clusters in COVID-19 patients	GIMAP8 CIZ1 ZNF318 LYSMD3 AQR HTT	1.77e-06	184	88	6	ce7f044956613118ee2e9fb6af2455c3166cb414
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Gen_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	EFNB1 RESF1 HMCN1 KDR HDAC7 SON	2.86e-06	200	88	6	dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCell	facs-Pancreas-Endocrine-18m-Epithelial-pancreatic_PP_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAM184B ZNF394 OBSCN TUBG1 NCS1	1.75e-05	162	88	5	ca1014e32996f777bff021830ce9a7cf4acf58d5
ToppCell	3'-Child04-06-SmallIntestine-Mesenchymal-fibroblastic-mLTo\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	BOC ENOX1 LTBP2 C1orf167 NCS1	2.21e-05	170	88	5	7653f1205d4e62abe7e31b1d76f9bbd665e45667
ToppCell	CV-Severe-7\|Severe / Virus stimulation, Condition and Cluster	KIF13B ARID2 E2F5 ADAM10 HTT	2.68e-05	177	88	5	82fdd6185b368f54f03de389427cbe3071d21a99
ToppCell	droplet-Liver-hepatocytes-3m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SNCAIP EFNB1 HMCN1 KDR ZMYM4	2.68e-05	177	88	5	8ef41ee5d63737b810ad7371b0437625e7e1badf
ToppCell	3'-GW_trimst-2-SmallIntestine-Endothelial-lymphatic_endothelial-LEC2_(MADCAM1+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TNFRSF9 HMCN1 KDR LTBP2 C1orf167	3.06e-05	182	88	5	f231e86524b628e6e11ac33d5c34be99d454a92a
ToppCell	droplet-Pancreas-Endocrine-21m-Epithelial-pancreatic_A_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAM184B PTPRD DMD TYMP NCS1	3.31e-05	185	88	5	4e40d3103ebf4a7066b7ce300b6ef700ba0e2863
ToppCell	droplet-Pancreas-Endocrine-21m-Epithelial-pancreatic_A_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAM184B PTPRD DMD TYMP NCS1	3.40e-05	186	88	5	16092819e9148dfe64f07c737652b6e533e699f7
ToppCell	TCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-1\|TCGA-Pancreas / Sample_Type by Project: Shred V9	TPR RESF1 HMCN1 ARID2 TAF1	3.40e-05	186	88	5	03db813598b67b1e08f759758a1c2023396921fa
ToppCell	Control-Fibroblasts-Other_FB\|Control / group, cell type (main and fine annotations)	BOC ENOX1 HMCN1 LTBP2 DMD	3.48e-05	187	88	5	bd3739c4a52aa1ba5deffd778e113a9800f7e158
ToppCell	TCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6\|TCGA-Prostate / Sample_Type by Project: Shred V9	USP9X DYNC1H1 ZMYM4 AQR SON	4.05e-05	193	88	5	abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCell	COVID-19-Fibroblasts-Other_FB\|COVID-19 / group, cell type (main and fine annotations)	BOC HMCN1 LTBP2 DMD PARD3	4.05e-05	193	88	5	e6b75be08e33c1de079fb5c02f0b4468128b369c
ToppCell	TCGA-Blood_and_Bone_Marrow-Primary_Tumor-Diffuse_large_B-cell_lymphoma-DLBCL-1\|TCGA-Blood_and_Bone_Marrow / Sample_Type by Project: Shred V9	BOC TNFRSF9 KDR LTBP2 DMD	4.15e-05	194	88	5	eaeeb84576270cc3fc59002ba33bff9639bb0b02
ToppCell	facs-Skin-Telogen-3m-Epithelial-outer_bulge\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BOC ENOX1 HMCN1 LTBP2 DMD	4.36e-05	196	88	5	c936014125b2ed5f796221b74acb77b8f8359875
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-1_mon-Proliferating-Cycling_Progenitors\|1_mon / Sample Type, Dataset, Time_group, and Cell type.	BOC USP9X E2F5 DMD PARD3	4.68e-05	199	88	5	358c4b3037f59378db8916a2fbe9ed4830cf1449
ToppCell	LPS_anti-TNF-Endothelial-Endothelial-Activated_Alv_Cap\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	CAMKK2 EFNB1 RESF1 KDR ADAM10	4.79e-05	200	88	5	bcd1cc96197929d6011903803b6f4ccdcf52b4ce
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Activated_Alv_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	EFNB1 RESF1 KDR ADAM10 DYNC1H1	4.79e-05	200	88	5	79e51afb57ca38aacebd0298e5e727b55c0cfff9
Disease	Colorectal Carcinoma	BOC TNFRSF9 PTPRD OBSCN LRP2 KDR DMD TYMP ZMYM4 MFF GABPB1	6.20e-06	702	86	11	C0009402
Disease	Malignant neoplasm of breast	BOC RIF1 PTPRD PER2 RAPH1 CYP3A4 OBSCN KDR ZNF318 DMD ADAM10 HDAC7 DOP1A	1.36e-05	1074	86	13	C0006142
Disease	vital capacity	FAM184B ZFAT MTMR11 DIS3L2 PTPRD HMCN1 LRP2 OTUD4 KDR LTBP2 CMSS1 PARD3 GABPB1	5.82e-05	1236	86	13	EFO_0004312
Disease	tauro-beta-muricholate measurement	ZNF394 CYP3A4	8.35e-05	5	86	2	EFO_0800213
Disease	glyco-beta-muricholate measurement	ZNF394 CYP3A4	8.35e-05	5	86	2	EFO_0800569
Disease	Mental Retardation, X-Linked 1	FRMPD4 USP9X DMD	1.12e-04	32	86	3	C2931498
Disease	androstenediol (3beta,17beta) monosulfate (1) measurement	ZNF394 CYP3A4	1.25e-04	6	86	2	EFO_0800294
Disease	prostatic hypertrophy (biomarker_via_orthology)	KDR CDK4	1.75e-04	7	86	2	DOID:11132 (biomarker_via_orthology)
Disease	Parkinson disease, disease progression measurement	SNCAIP PTPRD PARD3	2.02e-04	39	86	3	EFO_0008336, MONDO_0005180
Disease	high grade glioma (is_marker_for)	CAMKK2 KDR CDK4	2.53e-04	42	86	3	DOID:3070 (is_marker_for)
Disease	androstenediol (3beta,17beta) disulfate (1) measurement	ZNF394 CYP3A4	2.98e-04	9	86	2	EFO_0800278
Disease	Gastrointestinal Stromal Sarcoma	BOC DMD SUFU	3.53e-04	47	86	3	C3179349
Disease	5alpha-androstan-3beta,17alpha-diol disulfate measurement	ZNF394 CYP3A4	3.72e-04	10	86	2	EFO_0800289
Disease	Gastrointestinal Stromal Tumors	BOC DMD SUFU	4.24e-04	50	86	3	C0238198
Disease	DNA repair protein RAD51 homolog 4 measurement	ZNF394 CYP3A4	4.54e-04	11	86	2	EFO_0801531
Disease	androstenediol (3beta,17beta) monosulfate (2) measurement	ZNF394 CYP3A4	4.54e-04	11	86	2	EFO_0800295
Disease	Squamous cell carcinoma of the head and neck	HOXD10 TNFRSF10B CDK4	4.76e-04	52	86	3	C1168401
Disease	autoimmune thyroiditis (is_implicated_in)	ZFAT LRP2	5.44e-04	12	86	2	DOID:7188 (is_implicated_in)
Disease	5alpha-androstan-3beta,17beta-diol monosulfate (2) measurement	ZNF394 CYP3A4	5.44e-04	12	86	2	EFO_0800291
Disease	androstenediol (3alpha, 17alpha) monosulfate (3) measurement	ZNF394 CYP3A4	6.41e-04	13	86	2	EFO_0800293
Disease	5alpha-pregnan-3beta,20beta-diol monosulfate (1) measurement	ZNF394 CYP3A4	6.41e-04	13	86	2	EFO_0800284
Disease	X-21470 measurement	ZNF394 CYP3A4	7.47e-04	14	86	2	EFO_0800817
Disease	Malformations of Cortical Development	DYNC1H1 TUBG1	7.47e-04	14	86	2	C1955869
Disease	nephroblastoma (is_implicated_in)	DIS3L2 REST	7.47e-04	14	86	2	DOID:2154 (is_implicated_in)
Disease	Cortical Dysplasia	DYNC1H1 TUBG1	7.47e-04	14	86	2	C0431380
Disease	5alpha-androstan-3alpha,17alpha-diol monosulfate measurement	ZNF394 CYP3A4	7.47e-04	14	86	2	EFO_0800283
Disease	16a-hydroxy DHEA 3-sulfate measurement	ZNF394 CYP3A4	8.60e-04	15	86	2	EFO_0800301
Disease	X-21410 measurement	ZNF394 CYP3A4	9.81e-04	16	86	2	EFO_0800813
Disease	andro steroid monosulfate C19H28O6S (1) measurement	ZNF394 CYP3A4	9.81e-04	16	86	2	EFO_0800305
Disease	dehydroepiandrosterone sulphate measurement	ZNF394 PTPRD CYP3A4	1.04e-03	68	86	3	EFO_0007001
Disease	susceptibility to mononucleosis measurement	PTPRD DMD HDAC7	1.09e-03	69	86	3	EFO_0008403
Disease	5alpha-androstan-3alpha,17beta-diol monosulfate (1) measurement	ZNF394 CYP3A4	1.25e-03	18	86	2	EFO_0800288
Disease	metabolonic lactone sulfate measurement	ZNF394 CYP3A4	1.39e-03	19	86	2	EFO_0800659
Disease	etiocholanolone glucuronide measurement	ZNF394 CYP3A4	1.39e-03	19	86	2	EFO_0800362
Disease	urinary bladder cancer (is_implicated_in)	KDR MUC5B CDK4	1.44e-03	76	86	3	DOID:11054 (is_implicated_in)
Disease	anthropometric measurement	DIS3L2 PER2 LTBP2 SUFU	1.50e-03	168	86	4	EFO_0004302
Disease	X-24947 measurement	ZNF394 CYP3A4	1.87e-03	22	86	2	EFO_0800910
Disease	5alpha-androstan-3beta,17beta-diol disulfate measurement	ZNF394 CYP3A4	1.87e-03	22	86	2	EFO_0021115
Disease	severe acute respiratory syndrome, COVID-19	PTPRD FRMPD4 USP9X LTBP2 DMD PARD3	1.98e-03	447	86	6	EFO_0000694, MONDO_0100096
Disease	Intellectual Disability	AP4E1 FRMPD4 LRP2 TAF1 DYNC1H1 HTT	1.98e-03	447	86	6	C3714756
Disease	Prostatic Neoplasms	CAMKK2 CYP3A4 ARID2 CIZ1 LRP2 PARD3 TAF1L	2.16e-03	616	86	7	C0033578
Disease	Malignant neoplasm of prostate	CAMKK2 CYP3A4 ARID2 CIZ1 LRP2 PARD3 TAF1L	2.16e-03	616	86	7	C0376358
Disease	glioblastoma (is_implicated_in)	KDR CDK4	2.22e-03	24	86	2	DOID:3068 (is_implicated_in)
Disease	mean reticulocyte volume	ZFAT RESF1 RAPH1 OTUD4 ZNF318 REST TYMP HDAC7	2.31e-03	799	86	8	EFO_0010701
Disease	epiandrosterone sulfate measurement	ZNF394 CYP3A4	2.41e-03	25	86	2	EFO_0021120

Protein segments in the cluster

Peptide	Gene	Start	Entry
TPIQILGQEPDAEMV	AMOT	1066	Q4VCS5
QTPVMLPQDSGQRVE	C1orf167	61	Q5SNV9
EPVSPDTMENIQGNI	CFAP61	306	Q8NHU2
PQSQAQVEPVGLEMF	ANKRD23	101	Q86SG2
QMTGVEEVTQIPQEE	ADAM10	186	O14672
EVQAMALQETPPQVT	CARMIL2	71	Q6F5E8
TPTVEEQMDTVTGPN	ARMH4	536	Q86TY3
SPMEPQGTLDITQQD	ARID2	1391	Q68CP9
DTEVMQQETVPVPVP	CMSS1	31	Q9BQ75
AQEPIQMPETTETVL	HLA-DPA1	211	P20036
MVTGENINSVEPAQP	DOP1A	826	Q5JWR5
LPPAMVEEGEEVQNQ	AQR	1386	O60306
PVQTVLEGDNMETPV	DMD	3396	P11532
EPEDMEQEPAQQVIT	DIS3L2	821	Q8IYB7
ESGALPVPQESIMEN	AP4E1	726	Q9UPM8
PVPQESIMENVDQAI	AP4E1	731	Q9UPM8
AMLVVPQAETQGPVE	MUC5B	16	Q9HC84
AEISEQPTMATVVPQ	RAPH1	1136	Q70E73
QTEASVNGQMPQPEI	OTUD4	771	Q01804
EVVDVNDNPPEVMVS	PCDHB1	336	Q9Y5F3
AMDPQDLQNTEVPIA	RAB3GAP2	1341	Q9H2M9
PAPDEPVQMEVVQEG	REST	646	Q13127
PVQMEVVQEGPAQKE	REST	651	Q13127
ELPPPMETAQTEVAQ	REST	686	Q13127
VESAPMQVVQKEPVQ	REST	716	Q13127
PSQQREMENGIVPTK	LYSMD3	266	Q7Z3D4
MVGNTVELPEEENTP	NCS1	131	P62166
FQEGVPNASVIMQVP	MFF	66	Q9GZY8
NIAPQKEEPEMGSVQ	MTMR11	11	A4FU01
EEQGGVVQPALEMPE	FLYWCH1	86	Q4VC44
EPGQGPEMQEVLLEV	FAM184B	186	Q9ULE4
MPDGQQVLTVPATDI	GABPB1	301	Q06547
DPQLAPNVVVTEAVM	DSG4	926	Q86SJ6
DGQQPVLAITDPDMI	CYP3A4	76	P08684
PQPSQVPLQEDVDMS	PER2	21	O15055
QEPDSMAGVIVEQGQ	PLXNA3	146	P51805
QTDEEKQQGLPVVMP	PDE8A	751	O60658
QGAVEPMQIDVDPQE	GPS1	11	Q13098
LSTQEDVMVPVSGNP	LRP2	726	P98164
YVPPNIMGEEQNVSV	HMCN1	2101	Q96RW7
PPSMQVTIEDVQAQT	OBSCN	6356	Q5VST9
QVVDVNDNPPQVTMS	PCDHB16	336	Q9NRJ7
VTQPLVMEQEESPPE	HTT	2476	P42858
NVQVFEPPEVTMELS	BOC	316	Q9BWV1
TQLEVPIPEMGQNGQ	E2F5	196	Q15329
PVQSVVPEMEESGAQ	CDK4	256	P11802
PGDQIVMINDEPVSA	FRMPD4	116	Q14CM0
IVLEDTQPFSQPMVG	CENPT	236	Q96BT3
QEEQSMTPPGKVVTV	CRAMP1	761	Q96RY5
IMKVGQDPNAVTPEQ	EFNB1	161	P98172
GQEVVVVDTPSFNQM	GIMAP8	486	Q8ND71
MNEPVSGQEPTKVSQ	HOXD10	201	P28358
LPQQGRQLDMTEEEP	AKNA	111	Q7Z591
VNIQDTMIGELPPQT	BPIFB6	276	Q8NFQ5
PMPEQGIAEIQEEQV	LTBP2	816	Q14767
VFELVNQGPVMEVPT	CAMKK2	266	Q96RR4
QGEVPEPQDMKVAEV	DYNC1H1	496	Q14204
DTPMPELQVGPQEQE	HDAC7	51	Q8WUI4
GVENITQLPQELPQM	ENOX1	6	Q8TC92
DPTNVGPEVKQQVTM	FAM120B	556	Q96EK7
MQIEEAGQTTPVEPN	PRR14L	516	Q5THK1
VMDRQGQIINPSEDP	BCKDHA	81	P12694
QLSPTVNMPQDDTVI	PARD3	746	Q8TEW0
DGMITVQLPEVPANE	PTPRD	1121	P23468
EEAQPEMGPDVLVQT	KIF13B	1506	Q9NQT8
PGVEGVNPMTQINQV	USP9X	1176	Q93008
NLVEMESQEAPGPAV	SPAG5	311	Q96R06
ENTPPVVISADQMVN	RIF1	1386	Q5UIP0
QITPVMPENAERQTP	RESF1	456	Q9HCM1
VIREEPQQNMSQPEV	TAF1L	566	Q8IZX4
GVIKEEPQQNMSQPE	TAF1	546	P21675
VTFEEPVVQMEQPSL	SNCAIP	816	Q9Y6H5
PVVQMEQPSLELNGE	SNCAIP	821	Q9Y6H5
PEPVGTQVSMEEIQN	CIZ1	506	Q9ULV3
GIEPFSLQVSPQEMV	CLUH	56	O75153
ANNETGIVMPVPEIS	SCLY	196	Q96I15
EAMQPVEEQAVEQPA	ZFAT	1226	Q9P243
IPMQQILEEAEPQGQ	ZNF394	206	Q53GI3
VFPNQDEMSDVVVQP	TUBG1	171	P23258
QEAMQSEGPVEHVPV	TPR	1726	P12270
EDPQMQPVQTPFGVV	SUFU	181	Q9UMX1
QPFMRPVQTTQEEDG	TNFRSF9	226	Q07011
VSILQPTQVPEQEME	TNFRSF10B	276	O14763
PTQVPEQEMEVQEPA	TNFRSF10B	281	O14763
EQEMEVQEPAEPTGV	TNFRSF10B	286	O14763
PVGNMTVVDSPGQEV	GTF3C2	16	Q8WUA4
PEITLQPDMQPTEQE	KDR	551	P35968
MEEPTAVEGQVQLPS	TMEM169	1	Q96HH4
VINEETTPPVMEQPV	WDR87	1201	Q6ZQQ6
QVPMNSEVIVDPIQG	ZNF772	11	Q68DY9
EDNMVPQGMPEQETT	ZNF318	2251	Q5VUA4
PQGMPEQETTVGAIQ	ZNF318	2256	Q5VUA4
IPGFNVIQSPEQMQV	TYMP	161	P19971
QPVTTTELEQPVGMT	SON	506	P18583
EVPVGVEMAENTDNP	ZMYM4	1451	Q5VZL5
MPGEATETVPAIEQQ	NACA4P	1	Q9BZK3