Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	alcohol dehydrogenase (NADP+) activity	DHRS4L2 AKR1E2 DHRS4 AKR1B10 AKR1B15 AKR1B1	1.05e-08	27	119	6	GO:0008106
GeneOntologyMolecularFunction	retinal dehydrogenase activity	DHRS4L2 DHRS4 AKR1B10 AKR1B15 AKR1B1	1.32e-08	14	119	5	GO:0001758
GeneOntologyMolecularFunction	all-trans-retinol dehydrogenase (NADP+) activity	DHRS4L2 DHRS4 AKR1B10 AKR1B15 AKR1B1	1.98e-08	15	119	5	GO:0052650
GeneOntologyMolecularFunction	aldo-keto reductase (NADPH) activity	DHRS4L2 AKR1E2 DHRS4 AKR1B10 AKR1B15 AKR1B1	3.15e-08	32	119	6	GO:0004033
GeneOntologyMolecularFunction	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	DHRS4L2 DHRS4 AKR1B10 AKR1B15 FAR1 AKR1B1	3.95e-07	48	119	6	GO:0016620
GeneOntologyMolecularFunction	allyl-alcohol dehydrogenase activity	AKR1B10 AKR1B15 AKR1B1	8.22e-07	4	119	3	GO:0047655
GeneOntologyMolecularFunction	oxidoreductase activity, acting on the aldehyde or oxo group of donors	DHRS4L2 DHRS4 AKR1B10 AKR1B15 FAR1 AKR1B1	1.00e-06	56	119	6	GO:0016903
GeneOntologyMolecularFunction	aldose reductase (NADPH) activity	AKR1E2 AKR1B10 AKR1B15 AKR1B1	1.15e-06	14	119	4	GO:0004032
GeneOntologyMolecularFunction	ABC-type polyamine transporter activity	ATP13A2 ATP13A3	3.52e-05	2	119	2	GO:0015417
GeneOntologyMolecularFunction	histone ubiquitin ligase activity	UBR2 HUWE1 RNF20	4.37e-05	12	119	3	GO:0140852
GeneOntologyMolecularFunction	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	DHRS4L2 AKR1E2 DHRS4 AKR1B10 AKR1B15 AKR1B1	1.13e-04	127	119	6	GO:0016616
GeneOntologyMolecularFunction	oxidoreductase activity, acting on CH-OH group of donors	DHRS4L2 AKR1E2 DHRS4 AKR1B10 AKR1B15 AKR1B1	1.79e-04	138	119	6	GO:0016614
GeneOntologyMolecularFunction	indanol dehydrogenase activity	AKR1B10 AKR1B15	2.10e-04	4	119	2	GO:0047718
GeneOntologyMolecularFunction	serotonin-gated monoatomic cation channel activity	HTR3E HTR3C	3.48e-04	5	119	2	GO:0022850
GeneOntologyMolecularFunction	cytoskeleton-nuclear membrane anchor activity	SYNE1 SYNE2	3.48e-04	5	119	2	GO:0140444
GeneOntologyMolecularFunction	geranylgeranyl reductase activity	AKR1B10 AKR1B15	5.20e-04	6	119	2	GO:0045550
GeneOntologyMolecularFunction	serotonin receptor activity	HTR3E HTR3C	5.20e-04	6	119	2	GO:0099589
GeneOntologyMolecularFunction	1-phosphatidylinositol-4-phosphate 3-kinase activity	PIK3CB PIK3CG	7.25e-04	7	119	2	GO:0035005
GeneOntologyMolecularFunction	1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity	PIK3CB PIK3CG	7.25e-04	7	119	2	GO:0046934
GeneOntologyMolecularFunction	ephrin receptor binding	ANKS1B PIK3CG ANKS1A	9.02e-04	32	119	3	GO:0046875
GeneOntologyMolecularFunction	3-keto sterol reductase activity	DHRS4L2 DHRS4	9.63e-04	8	119	2	GO:0000253
GeneOntologyMolecularFunction	carbonyl reductase (NADPH) activity	DHRS4L2 DHRS4	1.23e-03	9	119	2	GO:0004090
GeneOntologyMolecularFunction	NADP+ binding	AKR1B10 AKR1B15	1.23e-03	9	119	2	GO:0070401
GeneOntologyMolecularFunction	polyamine transmembrane transporter activity	ATP13A2 ATP13A3	1.87e-03	11	119	2	GO:0015203
GeneOntologyMolecularFunction	1-phosphatidylinositol-3-kinase activity	PIK3CB PIK3CG	1.87e-03	11	119	2	GO:0016303
GeneOntologyMolecularFunction	voltage-gated chloride channel activity	CLCN3 CLCN4	1.87e-03	11	119	2	GO:0005247
GeneOntologyMolecularFunction	ubiquitin-protein transferase activity	UBR2 RNF40 HUWE1 CCNC RNF214 HACE1 RNF20 TNFAIP1 MED12	2.11e-03	473	119	9	GO:0004842
GeneOntologyMolecularFunction	excitatory extracellular ligand-gated monoatomic ion channel activity	HTR3E HTR3C GRIN2B	2.14e-03	43	119	3	GO:0005231
GeneOntologyBiologicalProcess	chemical synaptic transmission, postsynaptic	UNC13B RELN SYNE1 HTR3E ANKS1B HTR3C GRIN2B RIMS1	1.95e-06	147	117	8	GO:0099565
GeneOntologyBiologicalProcess	hormone metabolic process	RELN BCHE IDE GH2 DHRS4 AKR1B10 AKR1B15 SCPEP1 AKR1B1 ECE2	5.43e-06	286	117	10	GO:0042445
GeneOntologyBiologicalProcess	retinoid metabolic process	DHRS4L2 DHRS4 AKR1B10 AKR1B15 SCPEP1 AKR1B1	1.16e-05	89	117	6	GO:0001523
GeneOntologyBiologicalProcess	diterpenoid metabolic process	DHRS4L2 DHRS4 AKR1B10 AKR1B15 SCPEP1 AKR1B1	1.59e-05	94	117	6	GO:0016101
GeneOntologyBiologicalProcess	positive regulation of inhibitory postsynaptic potential	UNC13B GRIN2B RIMS1	2.07e-05	10	117	3	GO:0097151
GeneOntologyBiologicalProcess	terpenoid metabolic process	DHRS4L2 DHRS4 AKR1B10 AKR1B15 SCPEP1 AKR1B1	2.98e-05	105	117	6	GO:0006721
GeneOntologyBiologicalProcess	positive regulation of synaptic vesicle priming	UNC13B RIMS1	3.19e-05	2	117	2	GO:0010808
GeneOntologyBiologicalProcess	regulation of hormone levels	RELN BCHE IDE RAB44 SIRT3 GH2 DHRS4 AKR1B10 AKR1B15 SCPEP1 ABCC2 AKR1B1 BAIAP3 ECE2	3.35e-05	684	117	14	GO:0010817
GeneOntologyBiologicalProcess	modulation of inhibitory postsynaptic potential	UNC13B GRIN2B RIMS1	3.77e-05	12	117	3	GO:0098828
GeneOntologyBiologicalProcess	secretory granule localization	UNC13B PIK3CG RIMS1 BAIAP3	4.00e-05	34	117	4	GO:0032252
GeneOntologyBiologicalProcess	regulation of postsynaptic membrane potential	UNC13B RELN SYNE1 HTR3E HTR3C GRIN2B RIMS1	7.59e-05	180	117	7	GO:0060078
GeneOntologyBiologicalProcess	dense core granule exocytosis	UNC13B RIMS1 BAIAP3	7.70e-05	15	117	3	GO:1990504
GeneOntologyBiologicalProcess	excitatory postsynaptic potential	RELN SYNE1 HTR3E HTR3C GRIN2B RIMS1	9.86e-05	130	117	6	GO:0060079
GeneOntologyBiologicalProcess	regulation of vesicle-mediated transport	UNC13B SYNE1 ATP13A2 TF ANKRD13A SLC11A1 PIK3CB EEF2K CACNA1G RIMS1 BAIAP3 RAB26 HCK	1.06e-04	667	117	13	GO:0060627
GeneOntologyBiologicalProcess	isoprenoid metabolic process	DHRS4L2 DHRS4 AKR1B10 AKR1B15 SCPEP1 AKR1B1	1.73e-04	144	117	6	GO:0006720
GeneOntologyBiologicalProcess	exocytosis	UNC13B ATP13A2 RAB44 PIK3CG EXOC6B CACNA1G RIMS1 BAIAP3 RAB26 HCK	1.84e-04	434	117	10	GO:0006887
GeneOntologyBiologicalProcess	retinol metabolic process	DHRS4 AKR1B10 AKR1B15 AKR1B1	2.32e-04	53	117	4	GO:0042572
GeneOntologyBiologicalProcess	regulated exocytosis	UNC13B RAB44 PIK3CG CACNA1G RIMS1 BAIAP3 RAB26 HCK	2.58e-04	291	117	8	GO:0045055
GeneOntologyBiologicalProcess	positive regulation of nervous system process	UNC13B GRIN2B TF RIMS1	3.08e-04	57	117	4	GO:0031646
GeneOntologyBiologicalProcess	regulation of dense core granule exocytosis	UNC13B BAIAP3	3.15e-04	5	117	2	GO:1905413
GeneOntologyCellularComponent	late endosome	GRIN2B ATP13A2 TF ANKRD13A SLC11A1 CLCN3 CLCN4 ATP13A3 BAIAP3	1.95e-04	348	121	9	GO:0005770
GeneOntologyCellularComponent	HULC complex	RNF40 RNF20	1.98e-04	4	121	2	GO:0033503
GeneOntologyCellularComponent	serotonin-activated cation-selective channel complex	HTR3E HTR3C	3.29e-04	5	121	2	GO:1904602
GeneOntologyCellularComponent	serotonin receptor complex	HTR3E HTR3C	3.29e-04	5	121	2	GO:0098665
GeneOntologyCellularComponent	CKM complex	CCNC MED12	3.29e-04	5	121	2	GO:1990508
GeneOntologyCellularComponent	late endosome membrane	ATP13A2 SLC11A1 CLCN3 CLCN4 ATP13A3 BAIAP3	6.18e-04	179	121	6	GO:0031902
Domain	ALDOKETO_REDUCTASE_1	AKR1E2 AKR1B10 AKR1B15 AKR1B1	2.78e-07	10	115	4	PS00798
Domain	ALDOKETO_REDUCTASE_2	AKR1E2 AKR1B10 AKR1B15 AKR1B1	2.78e-07	10	115	4	PS00062
Domain	ALDOKETO_REDUCTASE_3	AKR1E2 AKR1B10 AKR1B15 AKR1B1	2.78e-07	10	115	4	PS00063
Domain	Aldo/ket_reductase_CS	AKR1E2 AKR1B10 AKR1B15 AKR1B1	2.78e-07	10	115	4	IPR018170
Domain	Aldo/keto_reductase	AKR1E2 AKR1B10 AKR1B15 AKR1B1	2.78e-07	10	115	4	IPR020471
Domain	-	AKR1E2 AKR1B10 AKR1B15 AKR1B1	2.34e-06	16	115	4	3.20.20.100
Domain	NADP_OxRdtase_dom	AKR1E2 AKR1B10 AKR1B15 AKR1B1	3.05e-06	17	115	4	IPR023210
Domain	Aldo_ket_red	AKR1E2 AKR1B10 AKR1B15 AKR1B1	3.05e-06	17	115	4	PF00248
Domain	Aldo/ket_red/Kv-b	AKR1E2 AKR1B10 AKR1B15 AKR1B1	3.05e-06	17	115	4	IPR001395
Domain	ANKS1	ANKS1B ANKS1A	3.76e-05	2	115	2	IPR033635
Domain	KASH	SYNE1 SYNE2	2.24e-04	4	115	2	IPR012315
Domain	P5-ATPase	ATP13A2 ATP13A3	2.24e-04	4	115	2	PF12409
Domain	KASH	SYNE1 SYNE2	2.24e-04	4	115	2	PS51049
Domain	KASH	SYNE1 SYNE2	2.24e-04	4	115	2	SM01249
Domain	KASH	SYNE1 SYNE2	2.24e-04	4	115	2	PF10541
Domain	PI3K_ABD	PIK3CB PIK3CG	2.24e-04	4	115	2	PS51544
Domain	PI3K_adapt-bd_dom	PIK3CB PIK3CG	2.24e-04	4	115	2	IPR003113
Domain	-	UNC13B PIK3CB PIK3CG ITSN2 RIMS1 BAIAP3	3.10e-04	148	115	6	2.60.40.150
Domain	Spectrin	SYNE1 DST SYNE2	3.68e-04	23	115	3	PF00435
Domain	ACTININ_2	SYNE1 DST SYNE2	3.68e-04	23	115	3	PS00020
Domain	ACTININ_1	SYNE1 DST SYNE2	3.68e-04	23	115	3	PS00019
Domain	Actinin_actin-bd_CS	SYNE1 DST SYNE2	3.68e-04	23	115	3	IPR001589
Domain	Munc13_dom-2	UNC13B BAIAP3	3.71e-04	5	115	2	IPR014772
Domain	MHD2	UNC13B BAIAP3	3.71e-04	5	115	2	PS51259
Domain	Munc13_subgr_dom-2	UNC13B BAIAP3	3.71e-04	5	115	2	IPR019558
Domain	P-type_TPase_V	ATP13A2 ATP13A3	3.71e-04	5	115	2	IPR006544
Domain	Membr_traf_MHD	UNC13B BAIAP3	3.71e-04	5	115	2	PF10540
Domain	C2_dom	UNC13B PIK3CB PIK3CG ITSN2 RIMS1 BAIAP3	5.35e-04	164	115	6	IPR000008
Domain	Alpha_kinase	ALPK3 EEF2K	5.55e-04	6	115	2	PF02816
Domain	MHCK_EF2_kinase	ALPK3 EEF2K	5.55e-04	6	115	2	IPR004166
Domain	ALPHA_KINASE	ALPK3 EEF2K	5.55e-04	6	115	2	PS51158
Domain	Alpha_kinase	ALPK3 EEF2K	5.55e-04	6	115	2	SM00811
Domain	Spectrin_repeat	SYNE1 DST SYNE2	7.39e-04	29	115	3	IPR002017
Domain	Munc13_1	UNC13B BAIAP3	7.74e-04	7	115	2	IPR014770
Domain	PI3K_Ras-bd_dom	PIK3CB PIK3CG	7.74e-04	7	115	2	IPR000341
Domain	MHD1	UNC13B BAIAP3	7.74e-04	7	115	2	PS51258
Domain	PI3K_rbd	PIK3CB PIK3CG	7.74e-04	7	115	2	SM00144
Domain	DUF1041	UNC13B BAIAP3	7.74e-04	7	115	2	PF06292
Domain	CAPS_dom	UNC13B BAIAP3	7.74e-04	7	115	2	IPR010439
Domain	PI3K_rbd	PIK3CB PIK3CG	7.74e-04	7	115	2	PF00794
Domain	PI3K_RBD	PIK3CB PIK3CG	7.74e-04	7	115	2	PS51546
Domain	SPEC	SYNE1 DST SYNE2	9.90e-04	32	115	3	SM00150
Domain	Spectrin/alpha-actinin	SYNE1 DST SYNE2	9.90e-04	32	115	3	IPR018159
Domain	PI3K_C2	PIK3CB PIK3CG	1.03e-03	8	115	2	SM00142
Domain	PI3K_C2_dom	PIK3CB PIK3CG	1.03e-03	8	115	2	IPR002420
Domain	PI3K_C2	PIK3CB PIK3CG	1.03e-03	8	115	2	PF00792
Domain	PI3K_C2	PIK3CB PIK3CG	1.03e-03	8	115	2	PS51547
Domain	ARM-type_fold	DOCK9 MROH5 HUWE1 WDFY4 RNPEP PIK3CB PIK3CG NCAPD2	1.19e-03	339	115	8	IPR016024
Domain	Cl-channel_core	CLCN3 CLCN4	1.32e-03	9	115	2	IPR014743
Domain	PI3Ka	PIK3CB PIK3CG	1.32e-03	9	115	2	PF00613
Domain	-	CLCN3 CLCN4	1.32e-03	9	115	2	1.10.3080.10
Domain	Voltage_CLC	CLCN3 CLCN4	1.32e-03	9	115	2	PF00654
Domain	Cl-channel_volt-gated	CLCN3 CLCN4	1.32e-03	9	115	2	IPR001807
Domain	PI3Ka	PIK3CB PIK3CG	1.32e-03	9	115	2	SM00145
Domain	-	PIK3CB PIK3CG	1.32e-03	9	115	2	1.25.40.70
Domain	PI_Kinase	PIK3CB PIK3CG	1.64e-03	10	115	2	IPR015433
Domain	PInositide-3_kin_accessory_dom	PIK3CB PIK3CG	1.64e-03	10	115	2	IPR001263
Domain	PIK_HELICAL	PIK3CB PIK3CG	1.64e-03	10	115	2	PS51545
Domain	WWE	HUWE1 DDHD2	2.38e-03	12	115	2	PF02825
Domain	WWE-dom	HUWE1 DDHD2	2.38e-03	12	115	2	IPR004170
Domain	WWE	HUWE1 DDHD2	2.38e-03	12	115	2	PS50918
Domain	PI3/4_kinase_CS	PIK3CB PIK3CG	3.74e-03	15	115	2	IPR018936
Domain	-	ANKS1B ELF3 DDHD2 ANKS1A	4.18e-03	106	115	4	1.10.150.50
Domain	CBS	CLCN3 CLCN4	4.26e-03	16	115	2	SM00116
Domain	-	PIK3CB PIK3CG	4.26e-03	16	115	2	1.10.1070.11
Domain	PI3Kc	PIK3CB PIK3CG	4.26e-03	16	115	2	SM00146
Domain	Methyltransf_11	ALKBH8 ECE2	4.26e-03	16	115	2	IPR013216
Domain	Methyltransf_11	ALKBH8 ECE2	4.26e-03	16	115	2	PF08241
Domain	PI3_PI4_kinase	PIK3CB PIK3CG	5.39e-03	18	115	2	PF00454
Domain	PI3_4_KINASE_1	PIK3CB PIK3CG	5.39e-03	18	115	2	PS00915
Domain	PI3_4_KINASE_2	PIK3CB PIK3CG	5.39e-03	18	115	2	PS00916
Domain	PI3/4_kinase_cat_dom	PIK3CB PIK3CG	5.39e-03	18	115	2	IPR000403
Domain	PI3_4_KINASE_3	PIK3CB PIK3CG	5.39e-03	18	115	2	PS50290
Domain	SAM/pointed	ANKS1B ELF3 DDHD2 ANKS1A	5.93e-03	117	115	4	IPR013761
Domain	ATPase_P-typ_cation-transptr_N	ATP13A2 ATP13A3	6.00e-03	19	115	2	IPR004014
Pubmed	Substrate specificity and catalytic efficiency of aldo-keto reductases with phospholipid aldehydes.	AKR1B10 AKR1B15 AKR1B1	4.11e-08	3	121	3	17381426
Pubmed	Comparisons of genomic structures and chromosomal locations of the mouse aldose reductase and aldose reductase-like genes.	AKR1B10 AKR1B15 AKR1B1	4.09e-07	5	121	3	10092857
Pubmed	An essential role for ClC-4 in transferrin receptor function revealed in studies of fibroblasts derived from Clcn4-null mice.	TF CLCN3 CLCN4	4.09e-07	5	121	3	19339555
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	SYNE1 DOCK9 ERBIN KMT2C DST SYNE2 CACNA1G BAIAP3	1.30e-06	225	121	8	12168954
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	RNGTT MARS1 SYNE1 EPB41L5 GON4L ERBIN MPRIP CCNC KMT2C EEF1B2 DST ITSN2 NCAPD2 BYSL POLR1B FAR1 MED12 MAN1B1	4.40e-06	1497	121	18	31527615
Pubmed	N-Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS-CoV-2 Main Protease.	RELN ACADVL SYNM MARS1 ZKSCAN8 DHRS4 DST RNF20 MRPS9	5.04e-06	360	121	9	33111431
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	IL12RB1 MARS1 SYNE1 ANKS1B GRIN2B ERBIN TF MPRIP EEF1B2 DST RNPEP AKR1B10 ITSN2 MRPS9 RIMS1 AKR1B1 HCK	9.76e-06	1431	121	17	37142655
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	IL12RB1 ACADVL SYNE1 ANKS1B DCC ERBIN EEF1B2 DST CLCN3 CLCN4 SYNE2 ITSN2 NCAPD2 MRPS9 RIMS1 ABCC2 CFAP46	1.08e-05	1442	121	17	35575683
Pubmed	Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database.	IDE TF MTHFR	1.15e-05	13	121	3	17192785
Pubmed	Role of AKR1B10 and AKR1B8 in the pathogenesis of non-alcoholic steatohepatitis (NASH) in mouse.	AKR1B10 AKR1B15	1.20e-05	2	121	2	34954342
Pubmed	5-HT3 receptor influences the washing phenotype and visual organization in obsessive-compulsive disorder supporting 5-HT3 receptor antagonists as novel treatment option.	HTR3E HTR3C	1.20e-05	2	121	2	23928294
Pubmed	Aldose reductase (AC)n gene polymorphism and susceptibility to diabetic retinopathy in Type 2 diabetes in Caucasians.	AKR1B10 AKR1B1	1.20e-05	2	121	2	15745835
Pubmed	Deficiency in mammalian histone H2B ubiquitin ligase Bre1 (Rnf20/Rnf40) leads to replication stress and chromosomal instability.	RNF40 RNF20	1.20e-05	2	121	2	22354749
Pubmed	Aldo-keto reductase family 1 member B8 is secreted via non-classical pathway.	AKR1B10 AKR1B15	1.20e-05	2	121	2	25120755
Pubmed	Murine aldo-keto reductase family 1 subfamily B: identification of AKR1B8 as an ortholog of human AKR1B10.	AKR1B10 AKR1B15	1.20e-05	2	121	2	21087085
Pubmed	Tissue-specific expression of two aldose reductase-like genes in mice: abundant expression of mouse vas deferens protein and fibroblast growth factor-regulated protein in the adrenal gland.	AKR1B10 AKR1B15	1.20e-05	2	121	2	8526877
Pubmed	Nesprins: a novel family of spectrin-repeat-containing proteins that localize to the nuclear membrane in multiple tissues.	SYNE1 SYNE2	1.20e-05	2	121	2	11792814
Pubmed	AKR1B8 deficiency drives severe DSS-induced acute colitis through invasion of luminal bacteria and activation of innate immunity.	AKR1B10 AKR1B15	1.20e-05	2	121	2	36518763
Pubmed	Nesprin-1 and nesprin-2 regulate endothelial cell shape and migration.	SYNE1 SYNE2	1.20e-05	2	121	2	24931616
Pubmed	Preferential association with ClC-3 permits sorting of ClC-4 into endosomal compartments.	CLCN3 CLCN4	1.20e-05	2	121	2	28972156
Pubmed	Alternative transcription initiation and splicing variants of the DHRS4 gene cluster.	DHRS4L2 DHRS4	1.20e-05	2	121	2	18754758
Pubmed	RNF20/RNF40 ameliorates streptozotocin-induced type 1 diabetes by activating vitamin D receptors in vivo.	RNF40 RNF20	1.20e-05	2	121	2	37422774
Pubmed	Munc13-1 is required for presynaptic long-term potentiation.	UNC13B RIMS1	1.20e-05	2	121	2	21849565
Pubmed	Impaired Barrier Function and Immunity in the Colon of Aldo-Keto Reductase 1B8 Deficient Mice.	AKR1B10 AKR1B15	1.20e-05	2	121	2	33644071
Pubmed	Reduced Mrp2 surface availability as PI3Kγ-mediated hepatocytic dysfunction reflecting a hallmark of cholestasis in sepsis.	PIK3CG ABCC2	1.20e-05	2	121	2	32753644
Pubmed	RIM1alpha forms a protein scaffold for regulating neurotransmitter release at the active zone.	UNC13B RIMS1	1.20e-05	2	121	2	11797009
Pubmed	E3 Ubiquitin Ligases RNF20 and RNF40 Are Required for Double-Stranded Break (DSB) Repair: Evidence for Monoubiquitination of Histone H2B Lysine 120 as a Novel Axis of DSB Signaling and Repair.	RNF40 RNF20	1.20e-05	2	121	2	30692271
Pubmed	Aldo Keto Reductases AKR1B1 and AKR1B10 in Cancer: Molecular Mechanisms and Signaling Networks.	AKR1B10 AKR1B1	1.20e-05	2	121	2	33945128
Pubmed	Evaluation of compound selectivity of aldo-keto reductases using differential scanning fluorimetry.	AKR1B10 AKR1B1	1.20e-05	2	121	2	28003428
Pubmed	Decreased levels of AKR1B1 and AKR1B10 in cancerous endometrium compared to adjacent non-cancerous tissue.	AKR1B10 AKR1B1	1.20e-05	2	121	2	23146748
Pubmed	Neither the butyrylcholinesterase K variant nor transferrin C2 variant confers a risk for Alzheimer's disease in Koreans.	BCHE TF	1.20e-05	2	121	2	11725818
Pubmed	Solute carrier 11a1 (Slc11a1; formerly Nramp1) regulates metabolism and release of iron acquired by phagocytic, but not transferrin-receptor-mediated, iron uptake.	TF SLC11A1	1.20e-05	2	121	2	11903051
Pubmed	Functional expression of novel human and murine AKR1B genes.	AKR1B10 AKR1B15	1.20e-05	2	121	2	21276782
Pubmed	Aldo-keto reductase family 1 B10 affects fatty acid synthesis by regulating the stability of acetyl-CoA carboxylase-alpha in breast cancer cells.	ACACA AKR1B10	1.20e-05	2	121	2	18056116
Pubmed	Compensatory upregulation of aldo-keto reductase 1B10 to protect hepatocytes against oxidative stress during hepatocarcinogenesis.	AKR1B10 AKR1B15	1.20e-05	2	121	2	31911858
Pubmed	Aldo-keto reductases-mediated cytotoxicity of 2-deoxyglucose: A novel anticancer mechanism.	AKR1B10 AKR1B1	1.20e-05	2	121	2	29617059
Pubmed	Uncoupling endosomal CLC chloride/proton exchange causes severe neurodegeneration.	CLCN3 CLCN4	1.20e-05	2	121	2	32118314
Pubmed	Multiple novel nesprin-1 and nesprin-2 variants act as versatile tissue-specific intracellular scaffolds.	SYNE1 SYNE2	1.20e-05	2	121	2	22768332
Pubmed	Identification and characterization of the autophosphorylation sites of phosphoinositide 3-kinase isoforms beta and gamma.	PIK3CB PIK3CG	1.20e-05	2	121	2	12502714
Pubmed	CDNA cloning of a short isoform of human liver NADP (H) -dependent retinol dehydrogenase/reductase and analysis of its characteristics.	DHRS4L2 DHRS4	1.20e-05	2	121	2	15473316
Pubmed	Inhibitor selectivity between aldo-keto reductase superfamily members AKR1B10 and AKR1B1: role of Trp112 (Trp111).	AKR1B10 AKR1B1	1.20e-05	2	121	2	24100137
Pubmed	Opposing roles of the aldo-keto reductases AKR1B1 and AKR1B10 in colorectal cancer.	AKR1B10 AKR1B1	1.20e-05	2	121	2	28929377
Pubmed	Expression of a novel alternatively spliced variant of NADP(H)-dependent retinol dehydrogenase/reductase with deletion of exon 3 in cervical squamous carcinoma.	DHRS4L2 DHRS4	1.20e-05	2	121	2	17230527
Pubmed	Syne-1 and Syne-2 play crucial roles in myonuclear anchorage and motor neuron innervation.	SYNE1 SYNE2	1.20e-05	2	121	2	17267447
Pubmed	1.7 A structure of FR-1, a fibroblast growth factor-induced member of the aldo-keto reductase family, complexed with coenzyme and inhibitor.	AKR1B10 AKR1B15	1.20e-05	2	121	2	7578036
Pubmed	Nesprins: tissue-specific expression of epsilon and other short isoforms.	SYNE1 SYNE2	1.20e-05	2	121	2	24718612
Pubmed	Characterization of the promoter of the gene for a mouse vas deferens protein related to the aldo-keto reductase superfamily: effect of steroid hormones and phorbol esters.	AKR1B10 AKR1B15	1.20e-05	2	121	2	8541228
Pubmed	Targeted ablation of nesprin 1 and nesprin 2 from murine myocardium results in cardiomyopathy, altered nuclear morphology and inhibition of the biomechanical gene response.	SYNE1 SYNE2	1.20e-05	2	121	2	24586179
Pubmed	Evaluation of an aldo-keto reductase gene signature with prognostic significance in colon cancer via activation of epithelial to mesenchymal transition and the p70S6K pathway.	AKR1B10 AKR1B1	1.20e-05	2	121	2	32628753
Pubmed	The p110beta isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110gamma.	PIK3CB PIK3CG	1.20e-05	2	121	2	18544649
Pubmed	Human aldose reductase and human small intestine aldose reductase are efficient retinal reductases: consequences for retinoid metabolism.	AKR1B10 AKR1B1	1.20e-05	2	121	2	12732097
Pubmed	RNF20 and RNF40 regulate vitamin D receptor-dependent signaling in inflammatory bowel disease.	RNF40 RNF20	1.20e-05	2	121	2	34088983
Pubmed	Nesprin-1 and -2 are involved in the pathogenesis of Emery Dreifuss muscular dystrophy and are critical for nuclear envelope integrity.	SYNE1 SYNE2	1.20e-05	2	121	2	17761684
Pubmed	Nesprin-1-alpha2 associates with kinesin at myotube outer nuclear membranes, but is restricted to neuromuscular junction nuclei in adult muscle.	SYNE1 SYNE2	1.20e-05	2	121	2	31578382
Pubmed	The 5-hydroxytryptamine type 3 (5-HT3) receptor reveals a novel determinant of single-channel conductance.	HTR3E HTR3C	1.20e-05	2	121	2	15157181
Pubmed	Identification and characterization of a novel human aldose reductase-like gene.	AKR1B10 AKR1B1	1.20e-05	2	121	2	9565553
Pubmed	Impaired self-renewal and increased colitis and dysplastic lesions in colonic mucosa of AKR1B8-deficient mice.	AKR1B10 AKR1B15	1.20e-05	2	121	2	25538260
Pubmed	Combined inhibition of PI3Kβ and PI3Kγ reduces fat mass by enhancing α-MSH-dependent sympathetic drive.	PIK3CB PIK3CG	1.20e-05	2	121	2	25406378
Pubmed	Deficiency in Bre1 impairs homologous recombination repair and cell cycle checkpoint response to radiation damage in mammalian cells.	RNF40 RNF20	1.20e-05	2	121	2	20738173
Pubmed	Human aldo-keto reductases 1B1 and 1B10: a comparative study on their enzyme activity toward electrophilic carbonyl compounds.	AKR1B10 AKR1B1	1.20e-05	2	121	2	21329684
Pubmed	Massively parallel in vivo CRISPR screening identifies RNF20/40 as epigenetic regulators of cardiomyocyte maturation.	RNF40 RNF20	1.20e-05	2	121	2	34290256
Pubmed	SUN1/2 and Syne/Nesprin-1/2 complexes connect centrosome to the nucleus during neurogenesis and neuronal migration in mice.	RELN SYNE1 SYNE2	1.45e-05	14	121	3	19874786
Pubmed	∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis.	ACADVL MARS1 PPA1 HUWE1 TF MPRIP ANKRD13A EEF1B2 ARL1 NCAPD2 FAR1	1.71e-05	647	121	11	26618866
Pubmed	Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons.	RNF40 KMT2C DST SYNE2 SLC39A6 DDHD2 AMOTL2 ECE2	1.80e-05	322	121	8	26514267
Pubmed	Small molecule inhibition of HIV-1-induced MHC-I down-regulation identifies a temporally regulated switch in Nef action.	PIK3CB PIK3CG HCK	1.81e-05	15	121	3	20702582
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	ACACA MARS1 EPB41L5 PPA1 HUWE1 ERBIN MPRIP EEF1B2 DST ERAL1 RNF20 NCAPD2 BYSL POLR1B FAR1 MED12	1.93e-05	1353	121	16	29467282
Pubmed	Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity.	UBR2 RNF40 HUWE1 HACE1 RNF20	2.12e-05	95	121	5	29643511
Pubmed	Exploration of 16 candidate genes identifies the association of IDE with Alzheimer's disease in Han Chinese.	IDE TF MTHFR	2.23e-05	16	121	3	20880607
Pubmed	CRL7SMU1 E3 ligase complex-driven H2B ubiquitylation functions in sister chromatid cohesion by regulating SMC1 expression.	RNF40 HUWE1 RNF20	3.23e-05	18	121	3	29507117
Pubmed	CpG island evolution in the mammalian DHRS4 gene cluster and its role in the regulation of gene transcription.	DHRS4L2 DHRS4	3.59e-05	3	121	2	27323117
Pubmed	RNF20-RNF40: A ubiquitin-driven link between gene expression and the DNA damage response.	RNF40 RNF20	3.59e-05	3	121	2	21827756
Pubmed	Identification of peroxisomal proteins by using M13 phage protein VI phage display: molecular evidence that mammalian peroxisomes contain a 2,4-dienoyl-CoA reductase.	DHRS4L2 DHRS4	3.59e-05	3	121	2	10333503
Pubmed	PI3K accelerates, but is not required for, neutrophil chemotaxis to fMLP.	PIK3CB PIK3CG	3.59e-05	3	121	2	18187452
Pubmed	GWAS of butyrylcholinesterase activity identifies four novel loci, independent effects within BCHE and secondary associations with metabolic risk factors.	BCHE RNPEP	3.59e-05	3	121	2	21862451
Pubmed	Bioinformatic analysis of the human DHRS4 gene cluster and a proposed mechanism for its transcriptional regulation.	DHRS4L2 DHRS4	3.59e-05	3	121	2	20525226
Pubmed	PI3Kβ plays a critical role in neutrophil activation by immune complexes.	PIK3CB PIK3CG	3.59e-05	3	121	2	21487106
Pubmed	The inner nuclear membrane protein Sun1 mediates the anchorage of Nesprin-2 to the nuclear envelope.	SYNE1 SYNE2	3.59e-05	3	121	2	16079285
Pubmed	Reduction of all-trans-retinal in the mouse liver peroxisome fraction by the short-chain dehydrogenase/reductase RRD: induction by the PPAR alpha ligand clofibrate.	DHRS4L2 DHRS4	3.59e-05	3	121	2	12680773
Pubmed	A delayed-early gene activated by fibroblast growth factor-1 encodes a protein related to aldose reductase.	AKR1B10 AKR1B15	3.59e-05	3	121	2	7510692
Pubmed	Genetic evidence for a predominant role of PI3Kbeta catalytic activity in ITAM- and integrin-mediated signaling in platelets.	PIK3CB PIK3CG	3.59e-05	3	121	2	19515725
Pubmed	Serotonin receptor diversity in the human colon: Expression of serotonin type 3 receptor subunits 5-HT3C, 5-HT3D, and 5-HT3E.	HTR3E HTR3C	3.59e-05	3	121	2	21192076
Pubmed	Cast: a novel protein of the cytomatrix at the active zone of synapses that forms a ternary complex with RIM1 and munc13-1.	UNC13B RIMS1	3.59e-05	3	121	2	12163476
Pubmed	Functional interaction of the active zone proteins Munc13-1 and RIM1 in synaptic vesicle priming.	UNC13B RIMS1	3.59e-05	3	121	2	11343654
Pubmed	Coincident signals from GPCRs and receptor tyrosine kinases are uniquely transduced by PI3Kβ in myeloid cells.	PIK3CB PIK3CG	3.59e-05	3	121	2	27531651
Pubmed	Identification of phosphotyrosine binding domain-containing proteins as novel downstream targets of the EphA8 signaling function.	ANKS1B ANKS1A	3.59e-05	3	121	2	17875921
Pubmed	Cloning, physical mapping and expression analysis of the human 5-HT3 serotonin receptor-like genes HTR3C, HTR3D and HTR3E.	HTR3E HTR3C	3.59e-05	3	121	2	12801637
Pubmed	ANKS1A regulates LDL receptor-related protein 1 (LRP1)-mediated cerebrovascular clearance in brain endothelial cells.	ANKS1B ANKS1A	3.59e-05	3	121	2	38123547
Pubmed	The tumor suppressor CDC73 interacts with the ring finger proteins RNF20 and RNF40 and is required for the maintenance of histone 2B monoubiquitination.	RNF40 RNF20	3.59e-05	3	121	2	22021426
Pubmed	Uncommon somatic mutations in metastatic NUT midline carcinoma.	DCC KMT2C	3.59e-05	3	121	2	28967088
Pubmed	Binding to Rab3A-interacting molecule RIM regulates the presynaptic recruitment of Munc13-1 and ubMunc13-2.	UNC13B RIMS1	3.59e-05	3	121	2	16704978
Pubmed	Phosphoinositide-3-kinase-dependent, MyD88-independent induction of CC-type chemokines characterizes the macrophage response to Toxoplasma gondii strains with high virulence.	PIK3CB PIK3CG	3.59e-05	3	121	2	17908814
Pubmed	Syne-1, a dystrophin- and Klarsicht-related protein associated with synaptic nuclei at the neuromuscular junction.	SYNE1 SYNE2	3.59e-05	3	121	2	10878022
Pubmed	The RING finger domain E3 ubiquitin ligases BRCA1 and the RNF20/RNF40 complex in global loss of the chromatin mark histone H2B monoubiquitination (H2Bub1) in cell line models and primary high-grade serous ovarian cancer.	RNF40 RNF20	3.59e-05	3	121	2	27798111
Pubmed	Histone H2B ubiquitin ligases RNF20 and RNF40 in androgen signaling and prostate cancer cell growth.	RNF40 RNF20	3.59e-05	3	121	2	22155569
Pubmed	Regulation and roles of PI3Kβ, a major actor in platelet signaling and functions.	PIK3CB PIK3CG	3.59e-05	3	121	2	21035500
Pubmed	Alternative splicing in the first alpha-helical region of the Rab-binding domain of Rim regulates Rab3A binding activity: is Rim a Rab3 effector protein during evolution?	UNC13B RIMS1	3.59e-05	3	121	2	15330860
Pubmed	Role and regulation of phosphatidylinositol 3-kinase β in platelet integrin α2β1 signaling.	PIK3CB PIK3CG	3.59e-05	3	121	2	22106345
Pubmed	Ubiquitylation of cyclin C by HACE1 regulates cisplatin-associated sensitivity in gastric cancer.	CCNC HACE1	3.59e-05	3	121	2	35343092
Pubmed	The nesprins are giant actin-binding proteins, orthologous to Drosophila melanogaster muscle protein MSP-300.	SYNE1 SYNE2	3.59e-05	3	121	2	12408964
Pubmed	Human aminopeptidase B (rnpep) on chromosome 1q32.2: complementary DNA, genomic structure and expression.	RNPEP ELF3	3.59e-05	3	121	2	12119107
Cytoband	3q27.1	HTR3E HTR3C ECE2	4.99e-05	27	121	3	3q27.1
Cytoband	Ensembl 112 genes in cytogenetic band chr3q27	HTR3E HTR3C LIPH ECE2	3.81e-04	128	121	4	chr3q27
Cytoband	Ensembl 112 genes in cytogenetic band chr7q33	AKR1B10 AKR1B15 AKR1B1	4.96e-04	58	121	3	chr7q33
GeneFamily	Aldo-keto reductases	AKR1E2 AKR1B10 AKR1B15 AKR1B1	7.86e-07	15	91	4	399
GeneFamily	Spectrin repeat containing nuclear envelope family	SYNE1 SYNE2	1.49e-04	4	91	2	1252
GeneFamily	5-hydroxytryptamine receptors, ionotropic	HTR3E HTR3C	2.48e-04	5	91	2	172
GeneFamily	Parkinson disease associated genes\|ATPase orphan transporters	ATP13A2 ATP13A3	2.48e-04	5	91	2	1213
GeneFamily	Phosphatidylinositol 3-kinase subunits	PIK3CB PIK3CG	6.88e-04	8	91	2	831
GeneFamily	Chloride voltage-gated channels	CLCN3 CLCN4	1.10e-03	10	91	2	302
Coexpression	GSE26030_TH1_VS_TH17_DAY5_POST_POLARIZATION_DN	IL12RB1 ACACA PPA1 CD83 NFS1 RNPEP BYSL EEF2K	3.85e-06	197	121	8	M8561
Coexpression	GSE38697_LIGHT_ZONE_VS_DARK_ZONE_BCELL_UP	ABRA MPRIP DST BYSL CCDC163 DDHD2 FAR1	1.68e-05	174	121	7	M9007
CoexpressionAtlas	DevelopingKidney_e15.5_Proximal Tubules_emap-28005_k-means-cluster#2_top-relative-expression-ranked_500	C5orf22 EPB41L5 HUWE1 CLCN3 ATP13A3	1.61e-05	56	120	5	gudmap_developingKidney_e15.5_Proximal Tubules_500_k2
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.3.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ACADVL APOBR SLC11A1 RNPEP ALPK3 SCPEP1 ADPGK	5.82e-07	178	121	7	0b398656f26c4061b11ccf98908d0e2e1367585a
ToppCell	3'-Child04-06-SmallIntestine-Epithelial-Tuft-related-Tuft\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HTR3E HTR3C GRIN2B KMT2C PIK3CG ELF3 HCK	7.54e-07	185	121	7	686ed7550c6acd18e71e0076936ec5b07389adbd
ToppCell	IPF-Multiplet-Multiplet\|IPF / Disease state, Lineage and Cell class	CFAP251 SYNE1 LIPH SYNE2 ELF3 VWA3B CFAP46	1.07e-06	195	121	7	fce0c29574bb7aab181b9c00feb42681e285d1f2
ToppCell	IPF-Multiplet\|IPF / Disease state, Lineage and Cell class	CFAP251 SYNE1 LIPH SYNE2 ELF3 VWA3B CFAP46	1.07e-06	195	121	7	eacc0449ae6f3ad8002268cd061467684c6fb9a7
ToppCell	5'-Adult-SmallIntestine-Epithelial-Tuft-related-Tuft\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HTR3E HTR3C GRIN2B KMT2C PIK3CG HCK	6.68e-06	168	121	6	8072d0496b7b730c4601009eaa69ec5366d26d73
ToppCell	3'-Child09-12-SmallIntestine-Epithelial-Tuft-related-Tuft\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HTR3E HTR3C GRIN2B PIK3CG ELF3 HCK	6.91e-06	169	121	6	05e12524d68d409fed386ffad233305683b4575b
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	UNC13B ACACA EPB41L5 LIPH SYNE2 ELF3	7.15e-06	170	121	6	a2c738e441ced90eeeb1fcc6ca3269b918aaa298
ToppCell	Leuk-UTI-Myeloid-cDC1\|Leuk-UTI / Disease, Lineage and Cell Type	PPA1 WDFY4 AKR1E2 DST CLCN4 PIK3CB	7.90e-06	173	121	6	226bb8d881f32d65c60f5e4c034c6d465f8e7ba5
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex-lymphatic_endothelial_cell_of_renal_cortex_prolif\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	RELN TIGD1 GRIN2B ZFP69 PKHD1L1 RIMS1	8.71e-06	176	121	6	8eb91dcf55d4e3e28a72d447181bf6d2ad891fc6
ToppCell	LPS-antiTNF\|World / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	RNGTT CD83 DCC DHRS4 RIMS1 AKR1B1	9.29e-06	178	121	6	289d1425c4e57fabcca994b27f9af1c0ce5d5bec
ToppCell	COVID-19-Epithelial_cells-Airway_club\|COVID-19 / group, cell type (main and fine annotations)	UNC13B ACACA DOCK9 LIPH ELF3 RIMS1	1.16e-05	185	121	6	cfe6fd73d817e173fe803bc1683c291d9bcb8608
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CD83 WDFY4 RAB44 SLC11A1 ADAMTS14 HCK	1.31e-05	189	121	6	7ccea2df93bb4b37417bbc8f6c85a61ece95211a
ToppCell	5'-Adult-LargeIntestine-Epithelial-Tuft-related-Tuft\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HTR3E HTR3C GRIN2B PIK3CG ELF3 HCK	1.39e-05	191	121	6	54f07e4de61735051498846afb44b1798bed8144
ToppCell	Adult-Epithelial\|Adult / Lineage, Cell type, age group and donor	UNC13B ACACA DOCK9 EPB41L5 LIPH ELF3	1.43e-05	192	121	6	efb962a5fd3b9bdfd8cf8d13c435e29c8271713e
ToppCell	nucseq-Epithelial\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	UNC13B ACACA SYNE1 EPB41L5 LIPH ELF3	1.56e-05	195	121	6	9406866f99555198a9be311fbd65751b70f35446
ToppCell	5'-Adult-LargeIntestine-Epithelial-Tuft-related\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HTR3E APOBR ELF3 EEF2K ADAMTS14 HCK	1.70e-05	198	121	6	a631be84e29c277216d89ec6265bd43e87c1dc86
ToppCell	5'-Adult-LargeIntestine-Endothelial-lymphatic_endothelial-LEC6_(ADAMTS4+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RELN SYNM SYNE1 DOCK9 PKHD1L1 ANKS1A	1.70e-05	198	121	6	99d6a64f3410dae3019161feef20a8f06081a24b
ToppCell	Tracheal-NucSeq-Immune_Myeloid-Dendritic_cell-DC_activated\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CD83 ZFP69 APOBR WDFY4 HCK CFAP46	1.75e-05	199	121	6	6dc446a5d183b01bdf227e45bd88d0b3d8b1c56a
ToppCell	mild-HLA-DR+_CD83+_Monocyte\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	CD83 APOBR SLC11A1 SCPEP1 FAR1 HCK	1.80e-05	200	121	6	934c2efc780318c66d667ca75be0de350361d351
ToppCell	LPS_IL1RA_TNF-Endothelial-Endothelial-Artery\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	DOCK9 DST AKR1B10 SYNE2 ATP13A3 AKR1B1	1.80e-05	200	121	6	77ae679c35d3b9e2b620f34129f3a8d47e922c65
ToppCell	Control_saline-Endothelial-Endothelial-Artery\|Control_saline / Treatment groups by lineage, cell group, cell type	DST AKR1B10 SYNE2 ITSN2 ATP13A3 AKR1B1	1.80e-05	200	121	6	65b71f1e8da5c3750fcd0a2e66d9ef3125a3f78a
ToppCell	COVID-19-COVID-19_Mild-Lymphocyte-T/NK-CD4+_T_activated\|COVID-19_Mild / Disease, condition lineage and cell class	IL24 DOCK9 GSDMB MPRIP DST SYNE2	1.80e-05	200	121	6	d9e8a0d047d4403fb7265fde7448e23a7780785c
ToppCell	Sepsis-Leuk-UTI-Myeloid-cDC1\|Leuk-UTI / Disease, condition lineage and cell class	PPA1 WDFY4 AKR1E2 DST CLCN4 PIK3CB	1.80e-05	200	121	6	186852d54eced4c036876cc891773605068b56b5
ToppCell	LPS_only-Endothelial-Endothelial-Artery\|LPS_only / Treatment groups by lineage, cell group, cell type	DOCK9 DST AKR1B10 SYNE2 ATP13A3 AKR1B1	1.80e-05	200	121	6	b17eb1587ca86c3d40515128a00a8d8fd787fccf
ToppCell	LPS_anti-TNF-Endothelial-Endothelial-Artery\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	DOCK9 DST AKR1B10 SYNE2 ATP13A3 AKR1B1	1.80e-05	200	121	6	b1ff8d61b567f85006d6d20093f9c803b6d34674
ToppCell	(51)_cDC1\|World / shred on Cell_type and subtype	APOBR WDFY4 DST CLCN4 LIPH HCK	2.01e-05	204	121	6	a8cf4180c406674b7541917d1fc6127686ba5f8a
ToppCell	PND10-Immune-Immune_Myeloid-Granulocytic-Neutrophil-Neutrophil_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	APOBR RAB44 SLC11A1 HCK ADPGK	4.78e-05	145	121	5	ab0e254a8d01021619853a6c175f620ccef217d8
ToppCell	Tracheal-NucSeq-Immune_Myeloid-Macrophage_other-Macro_interstitial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	IL12RB1 APOBR WDFY4 SLC11A1 HCK	4.78e-05	145	121	5	778655fffd73df101e656154a41b478a1b695116
ToppCell	PND10-Immune-Immune_Myeloid-Granulocytic-Neutrophil\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	APOBR RAB44 SLC11A1 HCK ADPGK	4.78e-05	145	121	5	2beb4ea3838796c580076ab7769de877a3a0552c
ToppCell	LPS_only-Myeloid-Dendritic_cells\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CD83 ATP13A2 WDFY4 PIK3CG MAP2K6	5.26e-05	148	121	5	cb9365663f9cba35d47b5dd9079f42e88b70d915
ToppCell	356C-Lymphocytic-NK_cells-NK_cell_D2\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	SYNM TF EEF1B2 PIK3CB AMOTL2	6.36e-05	154	121	5	8dc8f02534c3ebda30bf9e702e36d0c53d89e5a5
ToppCell	5'-Adult-Appendix-Epithelial-Tuft-related-Tuft\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HTR3E HTR3C GRIN2B PIK3CG HCK	6.76e-05	156	121	5	58b9520fce6e259b36c3d59e82b712f5e7729e3e
ToppCell	10x5'-bone_marrow-Lymphocytic_T_CD4-T_CD4/CD8\|bone_marrow / Manually curated celltypes from each tissue	DOCK9 GSDMB HELB KMT2C SYNE2	6.76e-05	156	121	5	1545169694f686d28648a68b552c2ae606599d66
ToppCell	droplet-Marrow-nan-18m-Lymphocytic-NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SYNE1 CD83 SLC11A1 ADAMTS14 ADPGK	7.84e-05	161	121	5	3f3a2148c8d65e6a06f8d8116a3aa58dda17d618
ToppCell	facs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ANKS1B GRIN2B PKHD1L1 PTPRQ ABCC2	8.08e-05	162	121	5	bf886e22ff2a20353499004b53f25fb9e6574896
ToppCell	Multiple_Sclerosis-Lymphocyte-T_NK-Treg\|Multiple_Sclerosis / Disease, Lineage and Cell Type	ABRA ANKS1B MPRIP RNF214 SYNE2	8.08e-05	162	121	5	975d52e3cc101e7592425128e1099d30847a8a42
ToppCell	343B-Myeloid-Macrophage-SPP1+_Macrophage_3\|343B / Donor, Lineage, Cell class and subclass (all cells)	CD83 SLC11A1 PIK3CB CACNA1G HCK	8.08e-05	162	121	5	0acb8f7b51bf422d4f4f8e99bd10360163ae4eb7
ToppCell	5'-GW_trimst-2-LargeIntestine-Epithelial-Tuft-related-Tuft\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HTR3C LIPH PIK3CG ELF3 RAB26	8.08e-05	162	121	5	80619a93c57fe16daf91dc571874ef9ac888953d
ToppCell	Bronchial_Biopsy-Endothelial-Lymphatic\|Endothelial / Tissue, Lineage and Cell class of Lung Cells from 10X	RELN BCHE GRIN2B PKHD1L1 BAIAP3	8.31e-05	163	121	5	961c3a1303108afd680365466045f3460a30a7b0
ToppCell	343B-Myeloid-Macrophage-SPP1+_Macrophage\|343B / Donor, Lineage, Cell class and subclass (all cells)	RTL5 CD83 SLC11A1 RNPEP HCK	8.56e-05	164	121	5	057ca87847373eff7fe97dd9f4358509e66ca4c3
ToppCell	Endothelial-B-Donor_01\|World / lung cells shred on cell class, cell subclass, sample id	RELN SYNM ZNF208 GRIN2B PKHD1L1	8.81e-05	165	121	5	b6893882472aeb0d18e26f47eaec9d53688afcde
ToppCell	facs-Kidney-nan-3m-Myeloid-macrophage\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD83 APOBR SLC11A1 PIK3CG HCK	9.32e-05	167	121	5	991a93e1075d562b7391f0689b2f62c1351d48d1
ToppCell	facs-Kidney-nan-3m-Myeloid\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD83 APOBR SLC11A1 PIK3CG HCK	9.32e-05	167	121	5	f22d1471c785b30d096ec5cdc68974e850ed7de0
ToppCell	facs-Kidney-nan-3m-Myeloid-macrophage\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD83 APOBR SLC11A1 PIK3CG HCK	9.32e-05	167	121	5	934905aeaafbc215ec8f6a7903498b0e258b9220
ToppCell	Control\|World / group, cell type (main and fine annotations)	UNC13B SYNE1 ANKS1B EPB41L5 ELF3	9.59e-05	168	121	5	a3511faf2cd2c2b9c8363c8b99da3f3609c43ed6
ToppCell	metastatic_Lymph_Node-Myeloid_cells-Microglia/Mac\|Myeloid_cells / Location, Cell class and cell subclass	UNC13B CFAP251 ZKSCAN8 ALKBH8 CLCN4	9.86e-05	169	121	5	dba8f5599aa21feef5b7fdfed2e3ab54748d80f7
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Monocytic-Monocyte-derived_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CD83 APOBR WDFY4 SLC11A1 HCK	1.07e-04	172	121	5	72fbfa890995e47048b47199c170cc7dcd7661f8
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Monocytic\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CD83 APOBR WDFY4 SLC11A1 HCK	1.07e-04	172	121	5	2ca6f0d1181aabe0d0e3e8f2e193f08dbda42dea
ToppCell	Bronchial_Biopsy-Endothelial-Lymphatic\|Bronchial_Biopsy / Tissue, Lineage and Cell class of Lung Cells from 10X	IL12RB1 RELN BCHE GRIN2B PKHD1L1	1.07e-04	172	121	5	c41f5a66781bbf63afce7ca5d118cc6d8e0fe0bc
ToppCell	5'-Adult-LargeIntestine-Endothelial-lymphatic_endothelial-LEC3_(ADGRG3+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RELN SYNM DOCK9 PKHD1L1 ANKS1A	1.10e-04	173	121	5	7dc988fc0ba29990567bf1bcdeb3faeeee507eb1
ToppCell	facs-Trachea-nan-3m-Myeloid-macrophage\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD83 WDFY4 SLC11A1 PIK3CG HCK	1.10e-04	173	121	5	4e9b6c71030ae0d63d54e7255e4a10b25970fcc4
ToppCell	facs-Trachea-3m-Hematologic-myeloid-tracheal_macrophage\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CD83 WDFY4 SLC11A1 PIK3CG HCK	1.13e-04	174	121	5	d67fc8e30cc67fff8f7fdeaccb409d12ca0992c1
ToppCell	normal_Lymph_Node-Myeloid_cells-pDCs\|Myeloid_cells / Location, Cell class and cell subclass	CFAP251 GSDMB DST CLCN3 HACE1	1.13e-04	174	121	5	2274648b80dd74f3c948a779bba3391095964c34
ToppCell	facs-Trachea-3m-Hematologic-myeloid\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CD83 WDFY4 SLC11A1 PIK3CG HCK	1.16e-04	175	121	5	22fd7d9b4d403cc8061316855f78bad0eb705ce9
ToppCell	normal_Lymph_Node-Myeloid_cells-pDCs\|normal_Lymph_Node / Location, Cell class and cell subclass	CFAP251 GSDMB DST CLCN3 HACE1	1.19e-04	176	121	5	476794ef75ce5ab732d78cfeb4944e2f841e3e92
ToppCell	Caecum-Dendritic_cell-cDC1\|Dendritic_cell / Region, Cell class and subclass	NFS1 WDFY4 CLCN4 LIPH MAP2K6	1.19e-04	176	121	5	07cde50e1c18fcc2c5028efe1a087db4ef4d4783
ToppCell	metastatic_Brain-Myeloid_cells-CD141+_DCs\|metastatic_Brain / Location, Cell class and cell subclass	CD83 APOBR WDFY4 SERPINI2 HCK	1.19e-04	176	121	5	b9ba7026dee2272c0b483dc0cfa39f74b75f1634
ToppCell	COVID-19-Heart-Lymph_EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	RELN SYNM DOCK9 GRIN2B PKHD1L1	1.22e-04	177	121	5	326fde0734ef0d7272693966d346ca479b9d8147
ToppCell	metastatic_Brain-Myeloid_cells-Activated_DCs\|metastatic_Brain / Location, Cell class and cell subclass	CD83 WDFY4 RPUSD4 PIK3CG HCK	1.22e-04	177	121	5	739496fcc4156f4d5e3de9cd21cf3856037f0678
ToppCell	3'-Adult-LargeIntestine-Epithelial-Tuft-related-Tuft\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HTR3E HTR3C GRIN2B PIK3CG HCK	1.29e-04	179	121	5	906555ce2ca264a0215b120c7ff7c9b411de6a34
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d14-21-Myeloid-Dendritic-conventional_dendritic_cell-DC_c2-CD1C\|Severe-critical_convalescent_d14-21 / Compartment, severity and other cell annotations on 10x 3' data (130k)	CD83 WDFY4 DST BAIAP3 HCK	1.32e-04	180	121	5	2bc3fd2e4c249bf236340c5f0483747faa5c04ec
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d14-21-Myeloid-Dendritic-conventional_dendritic_cell\|Severe-critical_convalescent_d14-21 / Compartment, severity and other cell annotations on 10x 3' data (130k)	CD83 WDFY4 DST BAIAP3 HCK	1.36e-04	181	121	5	1b4eb044825ede6361928442524b1988c8ef58b3
ToppCell	3'-Pediatric_IBD-SmallIntestine-Hematopoietic-Myeloid-cDC1\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PPA1 APOBR WDFY4 PIK3CB HCK	1.36e-04	181	121	5	84ca8c9c036478a6d3a2071919d09065455d417c
ToppCell	PCW_05-06-Hematologic_ErythroMegGranulo-Hem_Granulocytic-im_mast/basophil_(18)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	APOBR WDFY4 RAB44 PIK3CG HCK	1.36e-04	181	121	5	f737f2b1f35747b81fdd8996e289bde5c290af61
ToppCell	facs-Marrow-Granulocytes-3m-Myeloid-granulocytopoietic_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SYNE1 PIK3CB SYNE2 NCAPD2 ADPGK	1.36e-04	181	121	5	566249e04dd491e6287ad2101b7b1ab11031ed8b
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d14-21-Myeloid-Dendritic\|Severe-critical_convalescent_d14-21 / Compartment, severity and other cell annotations on 10x 3' data (130k)	CD83 WDFY4 DST BAIAP3 HCK	1.36e-04	181	121	5	8d7ebbedc373d55e29da02ac2728b4f4118038f2
ToppCell	facs-Marrow-Granulocytes-3m-Myeloid-granulocytopoietic_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SYNE1 PIK3CB SYNE2 NCAPD2 ADPGK	1.36e-04	181	121	5	db9528dc7cb0230e4c36cb27da69102c588c7ee9
ToppCell	Adult-Epithelial-ciliated_cell-D122\|Adult / Lineage, Cell type, age group and donor	CFAP251 SERPINI2 VWA3B BAIAP3 CFAP46	1.39e-04	182	121	5	7ded554a4b441e6496db673ba206c0d76ccad7d9
ToppCell	PBMC-Mild-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	IL24 DOCK9 ERBIN MPRIP SYNE2	1.39e-04	182	121	5	1aea96ee211f7b9caef7fd385233f51be6021a73
ToppCell	5'-Adult-Appendix-Endothelial-lymphatic_endothelial-LEC6_(ADAMTS4+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RELN GOLGA8T SYNE1 DOCK9 PKHD1L1	1.39e-04	182	121	5	fd786c88826ad3d5cc5c3d80f8e392d6be1b5267
ToppCell	PBMC-Mild-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	IL24 DOCK9 ERBIN MPRIP SYNE2	1.39e-04	182	121	5	b427e43ee523a3ea9eca3207f3d82042f10f022a
ToppCell	PBMC-Mild-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	IL24 DOCK9 ERBIN MPRIP SYNE2	1.39e-04	182	121	5	c0f63cfc67d61c0877b7acb2946dfb35aae8a8f5
ToppCell	PBMC-Mild-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	IL24 DOCK9 ERBIN MPRIP SYNE2	1.39e-04	182	121	5	4cb182ef39be2044a6ad7266f332d4177591e550
ToppCell	PCW_05-06-Hematologic_ErythroMegGranulo-Hem_Granulocytic-im_neutrophils_(9)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	APOBR WDFY4 RAB44 PIK3CG HCK	1.43e-04	183	121	5	aed12b743334f3813db0c70d4fe7df90e0673f54
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN GRIN2B DCC PKHD1L1 PTPRQ	1.47e-04	184	121	5	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	tumor_Lung-Myeloid_cells-CD141+_DCs\|tumor_Lung / Location, Cell class and cell subclass	PPA1 APOBR WDFY4 MAP2K6 HCK	1.47e-04	184	121	5	f5cad8eb358898ae536cd7a7b37d3ce19528b801
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN GRIN2B DCC PKHD1L1 PTPRQ	1.47e-04	184	121	5	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN GRIN2B DCC PKHD1L1 PTPRQ	1.47e-04	184	121	5	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	5'-Adult-Appendix-Endothelial-lymphatic_endothelial\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RELN GOLGA8T SYNE1 DOCK9 PKHD1L1	1.47e-04	184	121	5	453295362888c9a59d0e73c7a5b15914c50ff591
ToppCell	wk_20-22-Epithelial-PNS-intermediate_Schwann\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	RELN RTL5 GRIN2B ALKBH8 ZNF566	1.47e-04	184	121	5	4e3ba64692868563a579902aa9c6f88cab5bce26
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)\|Adult / Lineage, Cell type, age group and donor	UNC13B ACACA EPB41L5 LIPH ELF3	1.51e-04	185	121	5	673f0c688ae6984bc8027df2da335787924f4137
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)\|Children_(3_yrs) / Lineage, Cell type, age group and donor	UNC13B ACACA EPB41L5 LIPH ELF3	1.51e-04	185	121	5	98b8ee42b89d97e4c9db01740e0c193503c68f2c
ToppCell	COVID-19-Neuronal_cells-Neuronal_cells\|COVID-19 / group, cell type (main and fine annotations)	RELN SYNM DOCK9 GRIN2B PKHD1L1	1.51e-04	185	121	5	4a095829992b39856a73bdfac03ee68b9aa0d3b8
ToppCell	COPD-Lymphoid-B\|COPD / Disease state, Lineage and Cell class	IL24 CD83 WDFY4 ANKRD13A ITSN2	1.51e-04	185	121	5	925e79c35c381dd44ec5fb921dca09ce43140135
ToppCell	Adult-Epithelial-ciliated_cell-D175\|Adult / Lineage, Cell type, age group and donor	CFAP251 SERPINI2 VWA3B BAIAP3 CFAP46	1.51e-04	185	121	5	30f4980dee6cd5959655f8d74049f3bfb5312611
ToppCell	COVID-19-Neuronal_cells\|COVID-19 / group, cell type (main and fine annotations)	RELN SYNM DOCK9 GRIN2B PKHD1L1	1.51e-04	185	121	5	36ce23893915f5c380cca39b2c33a516edf31c3a
ToppCell	PCW_05-06-Hematologic_Myeloid-Hem_Myeloid_monocytic-im_myeloid_progenitor3_(13)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	IL12RB1 APOBR WDFY4 PIK3CG HCK	1.54e-04	186	121	5	6575ec6a626cdea169ffd185d47828dfaa29475d
ToppCell	21-Trachea-Epithelial-Goblet-like_secretory\|Trachea / Age, Tissue, Lineage and Cell class	UNC13B TF LIPH ELF3 RIMS1	1.54e-04	186	121	5	f8cddad28896f0edf10a8645fa49a011b22b120d
ToppCell	Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)\|World / Lineage, Cell type, age group and donor	UNC13B ACACA EPB41L5 LIPH ELF3	1.58e-04	187	121	5	81cc8435b2704a9a8287b3f54acaae0f11dd4ac7
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ANKS1B EPB41L5 DST PTPRQ ADAMTS14	1.58e-04	187	121	5	24c2a3962da364e46e98abeab5f8234376fa26bb
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	UNC13B EPB41L5 LIPH PTPRQ ELF3	1.62e-04	188	121	5	eea652bab161f19148a883e7e3fe2523b36b3cea
ToppCell	Children_(3_yrs)-Immune-alveolar_macrophage_(MARCO_positive)-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	WDFY4 AKR1E2 SERPINI2 SLC11A1 HCK	1.62e-04	188	121	5	d7a9fb5b021e127b8d927658a55a71098d513b5c
ToppCell	facs-Marrow-KLS-3m-Hematologic-hematopoietic_stem_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SIRT3 MPRIP ANKRD13A EEF2K ANKS1A	1.66e-04	189	121	5	533685a921a65d84107d8d33c43b4fffde019143
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-DC-cDC2-C\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	IL24 GOLGA8T PPA1 CD83 HCK	1.66e-04	189	121	5	cfa45fa6b13fcd3f54c29c823885f5b938812474
ToppCell	Control-Myeloid-Macrophage_Alveolar\|Control / Disease state, Lineage and Cell class	DST SLC11A1 ALPK3 AKR1B1 ANKS1A	1.66e-04	189	121	5	937e876122bc4b94372a4104e9c1a9068c232018
ToppCell	facs-Marrow-KLS-3m-Hematologic\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SIRT3 MPRIP ANKRD13A EEF2K ANKS1A	1.66e-04	189	121	5	dca56ab02bf0505f9a352ff907edaef30906d854
ToppCell	remission-B_memory\|remission / disease stage, cell group and cell class	UNC13B WDFY4 PKHD1L1 ANKRD13A BAIAP3	1.66e-04	189	121	5	a7b434a5d2cc7c3952cb8f16d11219b691c6c2b6
ToppCell	PCW_05-06-Hematologic_ErythroMegGranulo-Hem_Granulocytic\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	APOBR WDFY4 RAB44 PIK3CG HCK	1.70e-04	190	121	5	8e254fc77dd1d2d2a4ce0700af3c37829ca089bf
ToppCell	facs-Marrow-KLS-3m\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SIRT3 MPRIP ANKRD13A EEF2K ANKS1A	1.70e-04	190	121	5	a513c1e7df62c28128c932a68b252ee8f0255172
ToppCell	human_hepatoblastoma-Inflammatory_Monocytes\|World / Sample and Cell Type and Tumor Cluster (all cells)	CD83 WDFY4 SLC11A1 FAR1 HCK	1.75e-04	191	121	5	3b59bfc6c106ae8a3fbcd4a74bd128c485724921
Drug	2,3-hexanedione	DHRS4 AKR1B10 AKR1B1	1.42e-06	5	120	3	ctd:C043231
Drug	ibotenic acid	SYNM BCHE GRIN2B CLCN3 CLCN4 RNPEP ANKS1A	3.85e-06	122	120	7	CID000001233
Drug	aldophosphamide	SYNE1 DCC AKR1B10 ABCC2	7.19e-06	24	120	4	CID000107744
Drug	alcophosphamide	DCC AKR1B10 AKR1B1	7.84e-06	8	120	3	CID000098612
Drug	K-II	BCHE IDE PPA1 ATP13A2 RNPEP AKR1B1	1.19e-05	96	120	6	CID000129400
Drug	Glyceraldehyde	AKR1B10 AKR1B15 AKR1B1	1.67e-05	10	120	3	ctd:D005985
Drug	4-oxoretinaldehyde	AKR1B10 AKR1B1	2.75e-05	2	120	2	ctd:C099660
Drug	propioin	AKR1B10 AKR1B1	2.75e-05	2	120	2	ctd:C523189
Drug	dehydroretinal	AKR1B10 AKR1B1	2.75e-05	2	120	2	ctd:C017184
Drug	Pentanones	AKR1B10 AKR1B1	2.75e-05	2	120	2	ctd:D010422
Drug	4-hydroxyretinal	AKR1B10 AKR1B1	2.75e-05	2	120	2	ctd:C057180
Drug	antiarol	SYNE1 AKR1B1	2.75e-05	2	120	2	CID000069505
Disease	Autistic Disorder	RELN HTR3C GRIN2B WDFY4 TF MTHFR PIK3CG RIMS1	9.39e-06	261	116	8	C0004352
Disease	Profound Mental Retardation	GON4L GRIN2B DCC EEF1B2 CACNA1G MAN1B1	1.90e-05	139	116	6	C0020796
Disease	Mental Retardation, Psychosocial	GON4L GRIN2B DCC EEF1B2 CACNA1G MAN1B1	1.90e-05	139	116	6	C0025363
Disease	Mental deficiency	GON4L GRIN2B DCC EEF1B2 CACNA1G MAN1B1	1.90e-05	139	116	6	C0917816
Disease	Dent disease (implicated_via_orthology)	CLCN3 CLCN4	4.58e-05	3	116	2	DOID:0050699 (implicated_via_orthology)
Disease	Acute Confusional Senile Dementia	RELN BCHE IDE TF MTHFR	4.59e-05	99	116	5	C0546126
Disease	Alzheimer's Disease, Focal Onset	RELN BCHE IDE TF MTHFR	4.59e-05	99	116	5	C0750900
Disease	Alzheimer Disease, Early Onset	RELN BCHE IDE TF MTHFR	4.59e-05	99	116	5	C0750901
Disease	Presenile dementia	RELN BCHE IDE TF MTHFR	4.59e-05	99	116	5	C0011265
Disease	Alzheimer Disease, Late Onset	RELN BCHE IDE TF MTHFR	4.59e-05	99	116	5	C0494463
Disease	Familial Alzheimer Disease (FAD)	RELN BCHE IDE TF MTHFR	4.81e-05	100	116	5	C0276496
Disease	Alzheimer's Disease	RELN BCHE IDE TF MTHFR	5.05e-05	101	116	5	C0002395
Disease	Breast Carcinoma	IL24 SYNE1 BCHE EEF1B2 ALKBH8 PIK3CB MTHFR ITSN2 SLC39A6 MED12	5.42e-05	538	116	10	C0678222
Disease	Intellectual Disability	SYNE1 GON4L GRIN2B DCC KMT2C EEF1B2 ALKBH8 CACNA1G MAN1B1	7.07e-05	447	116	9	C3714756
Disease	Alzheimer's disease (is_marker_for)	RELN ACADVL BCHE IDE GRIN2B SIRT3 EEF2K	7.29e-05	257	116	7	DOID:10652 (is_marker_for)
Disease	aldose reductase measurement	AKR1B10 AKR1B1	9.15e-05	4	116	2	EFO_0801364
Disease	juvenile-onset Parkinson's disease (implicated_via_orthology)	ATP13A2 ATP13A3	9.15e-05	4	116	2	DOID:0060893 (implicated_via_orthology)
Disease	Autosomal dominant Emery-Dreifuss muscular dystrophy	SYNE1 SYNE2	9.15e-05	4	116	2	cv:CN293514
Disease	triglyceride change measurement, intermediate density lipoprotein measurement	ARL1 AKR1B10	9.15e-05	4	116	2	EFO_0007681, EFO_0008595
Disease	Kufor-Rakeb syndrome (implicated_via_orthology)	ATP13A2 ATP13A3	9.15e-05	4	116	2	DOID:0060556 (implicated_via_orthology)
Disease	Autosomal Recessive Emery-Dreifuss Muscular Dystrophy	SYNE1 SYNE2	1.52e-04	5	116	2	C1450051
Disease	Autosomal Dominant Emery-Dreifuss Muscular Dystrophy (disorder)	SYNE1 SYNE2	1.52e-04	5	116	2	C0410190
Disease	Emery-Dreifuss muscular dystrophy	SYNE1 SYNE2	2.27e-04	6	116	2	cv:C0410189
Disease	Muscular Dystrophy, Emery-Dreifuss	SYNE1 SYNE2	2.27e-04	6	116	2	C0410189
Disease	butyrylcholinesterase measurement	BCHE RNPEP	2.27e-04	6	116	2	EFO_0004571
Disease	Mammary Carcinoma, Human	IL24 SYNE1 BCHE EEF1B2 ALKBH8 MTHFR ITSN2 SLC39A6 MED12	2.36e-04	525	116	9	C4704874
Disease	Mammary Neoplasms, Human	IL24 SYNE1 BCHE EEF1B2 ALKBH8 MTHFR ITSN2 SLC39A6 MED12	2.36e-04	525	116	9	C1257931
Disease	Mammary Neoplasms	IL24 SYNE1 BCHE EEF1B2 ALKBH8 MTHFR ITSN2 SLC39A6 MED12	2.43e-04	527	116	9	C1458155
Disease	Malignant neoplasm of breast	IL24 SYNE1 GSDMB BCHE PPA1 EEF1B2 ALKBH8 PIK3CB MTHFR SYNE2 ITSN2 SLC39A6 MED12	3.15e-04	1074	116	13	C0006142
Disease	osteopetrosis (implicated_via_orthology)	CLCN3 CLCN4	3.18e-04	7	116	2	DOID:13533 (implicated_via_orthology)
Disease	X-Linked Emery-Dreifuss Muscular Dystrophy	SYNE1 SYNE2	3.18e-04	7	116	2	C0751337
Disease	Drug toxicity	BCHE TF MTHFR ABCC2	3.43e-04	84	116	4	C0013221
Disease	Adverse reaction to drug	BCHE TF MTHFR ABCC2	3.43e-04	84	116	4	C0041755
Disease	type 1 diabetes mellitus (is_implicated_in)	BCHE TF SLC11A1 MTHFR	3.59e-04	85	116	4	DOID:9744 (is_implicated_in)
Disease	metabolite measurement	CFAP251 ACADVL DHRS4L2 DCC WDFY4 RNPEP AKR1B10 SYNE2 ABCC2	3.78e-04	560	116	9	EFO_0004725
Disease	symmetrical dimethylarginine measurement	AKR1B10 AKR1B15	5.42e-04	9	116	2	EFO_0006523
Disease	white matter growth measurement	AKR1B10 AKR1B1	5.42e-04	9	116	2	EFO_0009335
Disease	hereditary spastic paraplegia (implicated_via_orthology)	ATP13A2 ATP13A3 DDHD2	6.51e-04	43	116	3	DOID:2476 (implicated_via_orthology)
Disease	hyperhomocysteinemia (implicated_via_orthology)	BCHE GRIN2B	8.23e-04	11	116	2	DOID:9279 (implicated_via_orthology)
Disease	Parkinson Disease, Secondary Vascular	BCHE ATP13A2	9.86e-04	12	116	2	C0751414
Disease	Atherosclerotic Parkinsonism	BCHE ATP13A2	9.86e-04	12	116	2	C0751415
Disease	Emery-Dreifuss muscular dystrophy (implicated_via_orthology)	SYNE1 SYNE2	9.86e-04	12	116	2	DOID:11726 (implicated_via_orthology)
Disease	Secondary Parkinson Disease	BCHE ATP13A2	9.86e-04	12	116	2	C0030569
Disease	Gastrointestinal Diseases	MTHFR ABCC2	9.86e-04	12	116	2	C0017178
Disease	Functional Gastrointestinal Disorders	MTHFR ABCC2	9.86e-04	12	116	2	C0559031
Disease	Cholera Infantum	MTHFR ABCC2	9.86e-04	12	116	2	C1565321
Disease	Mental Retardation, X-Linked Nonsyndromic	HUWE1 CLCN4	1.16e-03	13	116	2	C3501611
Disease	glycochenodeoxycholate glucuronide (1) measurement	CACNA1G ABCC2	1.16e-03	13	116	2	EFO_0800474
Disease	neuronal ceroid lipofuscinosis (implicated_via_orthology)	ATP13A2 ATP13A3	1.35e-03	14	116	2	DOID:14503 (implicated_via_orthology)
Disease	anemia (is_implicated_in)	TF MTHFR	1.35e-03	14	116	2	DOID:2355 (is_implicated_in)
Disease	Alopecia, Male Pattern	MTHFR ABCC2	1.56e-03	15	116	2	C4083212
Disease	Androgenetic Alopecia	MTHFR ABCC2	1.56e-03	15	116	2	C0162311
Disease	Female pattern alopecia (disorder)	MTHFR ABCC2	1.56e-03	15	116	2	C0263477
Disease	Endometrial Neoplasms	MTHFR AKR1B10 AKR1B1	1.56e-03	58	116	3	C0014170
Disease	Seizures	BCHE ALKBH8 MTHFR HACE1 ABCC2	1.74e-03	218	116	5	C0036572
Disease	Colorectal Carcinoma	UNC13B ACACA SYNE1 HTR3C DCC KMT2C MTHFR AKR1B10 ABCC2	1.85e-03	702	116	9	C0009402
Disease	non-alcoholic fatty liver disease (biomarker_via_orthology)	ACACA ACADVL IDE	2.17e-03	65	116	3	DOID:0080208 (biomarker_via_orthology)
Disease	squamous cell carcinoma (is_implicated_in)	KMT2C MTHFR	2.25e-03	18	116	2	DOID:1749 (is_implicated_in)
Disease	non-alcoholic fatty liver disease (is_implicated_in)	MTHFR ABCC2	2.25e-03	18	116	2	DOID:0080208 (is_implicated_in)
Disease	inflammatory bowel disease (is_implicated_in)	SLC11A1 MTHFR	2.51e-03	19	116	2	DOID:0050589 (is_implicated_in)
Disease	event free survival time, urinary bladder cancer	GRIN2B DCC	2.51e-03	19	116	2	EFO_0000482, MONDO_0001187
Disease	Pseudopelade	MTHFR ABCC2	2.51e-03	19	116	2	C0086873
Disease	Alopecia	MTHFR ABCC2	2.51e-03	19	116	2	C0002170
Disease	congenital heart disease (implicated_via_orthology)	RNF40 KMT2C RNF20	2.57e-03	69	116	3	DOID:1682 (implicated_via_orthology)
Disease	temporal lobe epilepsy (is_marker_for)	RELN GRIN2B	2.78e-03	20	116	2	DOID:3328 (is_marker_for)
Disease	Manic Disorder	RELN MTHFR RIMS1	2.79e-03	71	116	3	C0024713
Disease	Bipolar Disorder	RELN SYNE1 DOCK9 BCHE GRIN2B MTHFR RIMS1	2.84e-03	477	116	7	C0005586
Disease	Endometrial Carcinoma	MTHFR AKR1B10 AKR1B1	2.90e-03	72	116	3	C0476089
Disease	chronic myeloid leukemia (is_implicated_in)	MTHFR ABCC2	3.06e-03	21	116	2	DOID:8552 (is_implicated_in)
Disease	cholangiocarcinoma (is_implicated_in)	MTHFR ABCC2	3.36e-03	22	116	2	DOID:4947 (is_implicated_in)
Disease	Nasopharyngeal carcinoma	SYNE1 CLCN3	3.36e-03	22	116	2	C2931822
Disease	carnitine measurement	CD83 RPUSD4 PIK3CG	3.38e-03	76	116	3	EFO_0010469
Disease	peak expiratory flow	DOCK9 BCHE ATP13A2 RPUSD4 DST DYNC2LI1 ANKS1A	3.60e-03	498	116	7	EFO_0009718
Disease	Manic	RELN MTHFR RIMS1	3.63e-03	78	116	3	C0338831
Disease	Depression, Bipolar	RELN MTHFR RIMS1	3.77e-03	79	116	3	C0005587

Protein segments in the cluster

Peptide	Gene	Start	Entry
EEQILALEADMTKWE	AMOTL2	556	Q9Y2J4
EVLEQLSGLKEFWMD	ERBIN	201	Q96RT1
KVLEMETTVEDLQWD	RNF40	271	O75150
DVGMVSDILFWILKE	ADPGK	351	Q9BRR6
KVLEMTGNIDEAEWE	BCHE	556	P06276
LWAAEELDMKAIEAV	RNPEP	511	Q9H4A4
VLESMIDDLQWDIDK	RNF20	266	Q5VTR2
MEVLTDKEGWILIDR	TNFAIP1	61	Q13829
LLDMEKEVWEITDAS	HTR3E	191	A5X5Y0
EEAWVLTEELSPKMT	BAIAP3	641	O94812
SEEEKMLLESVDWTE	ALKBH8	146	Q96BT7
DLKMFEAIGWILEEA	ATP13A3	561	Q9H7F0
LTLMDILDTDGDKWL	GSDMB	56	Q8TAX9
LVTDLAGVDWKMTDV	ALPK3	1771	Q96L96
IKQLEDLPMSIEEWA	CFAP46	1411	Q8IYW2
MQEKGVISDILDWKT	ACACA	2196	Q13085
AWEAMEELVDEGLVK	AKR1B10	141	O60218
LLGMDKEVWEITDTS	HTR3C	191	Q8WXA8
LSWIIELLEKDGMAF	ELF3	136	P78545
LDEAMEWLVETLKSR	ARL1	166	P40616
SEWDEIEKIMSSIGE	ANKS1A	666	Q92625
GVIDLAVDWMTDLKE	CLCN4	86	P51793
IMDVTEEVWDKTLDI	DHRS4	126	Q9BTZ2
GEVKTGELEWLMSLL	CALML6	51	Q8TD86
PAVLWEESEIMQKEL	CCDC163	66	A0A0D9SF12
VLLEEMDTYEWALKS	ADAMTS14	841	Q8WXS8
TWAAMEELVDEGLVK	AKR1B1	141	P15121
ILSATMEGKLVVWDI	CFAP251	461	Q8TBY9
LDVDGVKVKLQMWDT	RAB26	106	Q9ULW5
LGSKEESEMIFDWVD	RAB44	76	Q7Z6P3
TEGEMALIFVNWKEL	ITSN2	1246	Q9NZM3
WFAELSVDMEKILEI	CCNC	216	P24863
LAMELSAKELEEWEL	ANKRD13A	556	Q8IZ07
TVSWVKLLEGGEERM	CD83	46	Q01151
TSMDLLKKIWEVELI	ANKS1B	911	Q7Z6G8
LDKNIPIDDWIMETI	DCC	986	P43146
LMDVTEEVWDKTLDI	DHRS4L2	126	Q6PKH6
ELLKMWGEELTSEES	MTHFR	416	P42898
RAETKEIVSGWLEML	MPRIP	131	Q6WCQ1
KLIDSLEWMDDGLVN	FAR1	176	Q8WVX9
TLKWEKEEALGEMAT	KMT2C	1636	Q8NEZ4
APEEKIWEELSMLEV	MAGEA2	216	P43356
IWEELSMLEVFEGRE	MAGEA2	221	P43356
TEWKLEQSMREETLL	GOLGA8T	206	H3BQL2
EMVQDGIDLKSIKWT	NFS1	441	Q9Y697
LVEKMDWSIEAAVAT	RNGTT	141	O60942
EISEDTLMFWKGIAD	GMEB1	251	Q9Y692
IADEGTWTLEDRKMV	NUDCD2	71	Q8WVJ2
GESEDMSAKERLLLW	DST	146	Q03001
LESLLSWMVDTEELV	DST	5401	Q03001
LLWALTTEGDLKVEM	NCR3LG1	16	Q68D85
MPSETLWEIAKAEVE	DYNC2LI1	1	Q8TCX1
FEEALGQLVWMDEKT	ECE2	516	P0DPD6
RDELEWKLSESGAIM	PDCL3	191	Q9H2J4
WKLSESGAIMTDLEE	PDCL3	196	Q9H2J4
LLEDPWKSMESADLV	ERAL1	186	O75616
WKSMESADLVVVLVD	ERAL1	191	O75616
SLDEWLVLIATELMK	HACE1	366	Q8IYU2
LEETYMLAVTLDEWK	DDHD2	136	O94830
EWAMLLLEIIISGTV	MED12	1556	Q93074
VLWLTIELAIVGSDM	SLC11A1	136	P49279
LTLEDVWEVDEEMKT	ABCC2	221	Q92887
VWMDDLVKGLLSVED	LIPH	86	Q8WWY8
DELWEMALSKTIAAL	EXOC6B	371	Q9Y2D4
LSLDELWDMLGECLK	HUWE1	3851	Q7Z6Z7
DTMWILGLRKEFEEA	MAN1B1	296	Q9UKM7
FDSEEIKPDLWMSLE	RELN	2896	P78509
LLEGIVKDMEVWESS	NUP42	116	O15504
DIVITKLMEDVQIDW	PTPRQ	2161	Q9UMZ3
ILLEELDLSSMVIGW	RIMS1	1641	Q86UR5
KMVESTGWVLEEEPA	ATP13A2	576	Q9NQ11
PIQTEEMELAIFEKW	EPB41L5	191	Q9HCM4
IKSDVWSFGILLMEI	HCK	436	P08631
EVEMEEWITILNKIL	DOCK9	266	Q9BZ29
GSLEWELKLMDELAG	CACNA1G	1941	O43497
KETLFGELSIENWIM	C5orf22	71	Q49AR2
LTKALGEVDILLTWM	IL24	186	Q13007
SEALMLVWDASETEK	GON4L	2026	Q3T8J9
ALVVEMSWDKGERTE	IL12RB1	616	P42701
LGILAMIDEGETDWK	PPA1	141	Q15181
MIDEGETDWKVIAIN	PPA1	146	Q15181
LRLLMTEVAWTKDEL	IDE	686	P14735
TGEWLDDEVLIKMAS	EEF2K	121	O00418
SILLDVKPWDDETDM	EEF1B2	141	P24534
EDEEWPTLEKAATMT	BYSL	101	Q13895
WIIGSGSKEMLKEIE	HELB	231	Q8NG08
VKSDIWSLGITMIEL	MAP2K6	236	P52564
MVIGASDVLEETWEK	MROH5	151	Q6ZUA9
RLDKETTGVMVLAWD	RPUSD4	151	Q96CM3
KELLWSTEMADLDEL	RTL5	286	Q5HYW3
SVIGLMDIKPVDWEE	SPATA5L1	451	Q9BVQ7
SLGIKELQDWMTDAI	SYNE1	3286	Q8NF91
WLVGQEFELEKMESI	SYNE2	1916	Q8WXH0
EGTRESILVWLTEMD	SYNE2	6251	Q8WXH0
LEDEKATLTLAMADW	SYNM	276	O15061
DLIVDTMGQEAWVRK	SCPEP1	371	Q9HB40
ESLVELLGWTEEMRD	SIRT3	371	Q9NTG7
SEEKILSLVGLSWMD	PIK3CB	156	P42338
ELKDAGVATLAWMVI	SLC39A6	586	Q13433
LVSELTKGWRVMEQE	ABRA	166	Q8N0Z2
MLQEIDILEDWTAIK	BRMS1	216	Q9HCU9
EMVEETTWQGLKELG	ACADVL	126	P49748
AWEAMEELVDEGLVK	AKR1B15	141	C9JRZ8
TWEAMEDLVITGLVK	AKR1E2	151	Q96JD6
MVEAGGLLEKWTLLE	APOBR	871	Q0VD83
EEEWEAMLPELKSTL	NCAPD2	476	Q15021
IDIAADWMTDLKEGI	CLCN3	146	P51790
MESIWETESLDLCLL	PIK3CG	851	P48736
KDLEEGIQTLMWRLE	GH2	141	P01242
IMEETERAWKAEILS	RNF214	341	Q8ND24
VARSMGGKEDLIWEL	TF	271	P02787
GSRWLIKEELEEMLV	MRPS9	196	P82933
DMEKVLVVWIEDQTS	TIGD1	81	Q96MW7
IEEVTPLWEETMLKA	WDFY4	2156	Q6ZS81
ILKWLSEMQEEEVEI	SERPINI2	271	O75830
WSTLEAETLMKDDEI	UNC13B	96	O14795
KVLSLMDAVDWQEGE	PKHD1L1	3181	Q86WI1
MGITLDKWVELISED	TMEM225	26	Q6GV28
DLIIFLEEGKESWNM	ZNF208	51	O43345
EIESTQWEIMEKLTR	ZNF566	96	Q969W8
LSDKEMSILLAEEWL	VWA3B	806	Q502W6
MSILLAEEWLDDKSS	VWA3B	811	Q502W6
VLLDGVMVGWVDKDL	POLR1B	556	Q9H9Y6
LTWEKESELPADLEM	UBR2	206	Q8IWV8
LEFWEGDMVLSVAKL	USP40	576	Q9NVE5
EEIAMAVTAWEKGLE	MARS1	231	P56192
KIEDMAVSLIREEWL	ZKSCAN8	221	Q15776
LWEDVTKMFEGEALL	ZFP69	31	Q49AA0
GWELEEVLLLDMSLD	GRIN2B	196	Q13224