Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	synapse-associated extracellular matrix	LAMA5 NCAN TNR	1.37e-04	13	168	3	GO:0099535
GeneOntologyCellularComponent	extracellular matrix of synaptic cleft	LAMA5 TNR	1.92e-04	3	168	2	GO:0098965
GeneOntologyCellularComponent	tenascin complex	TNR TNXB	3.81e-04	4	168	2	GO:0090733
HumanPheno	Abnormal mitral valve morphology	FLNC DOHH RPS6KA3 DPYSL5 PPP1R13L CBS RYR1 PIK3R2 DCHS1 ADAMTS15 ANKRD11 ELN TNXB	9.14e-06	257	62	13	HP:0001633
Domain	FN3	NPHS1 PAPPA2 FLNC COL7A1 FN1 FNDC1 TNR TNXB CNTN1	3.83e-05	185	164	9	SM00060
Domain	-	A1BG NPHS1 PAPPA2 FLNC COL7A1 FN1 SGCA CADM4 TRIM3 FNDC1 CILP2 SIGIRR NCAN SIGLEC1 TNR TNXB CNTN1	7.67e-05	663	164	17	2.60.40.10
Domain	FN3_dom	NPHS1 PAPPA2 FLNC COL7A1 FN1 FNDC1 TNR TNXB CNTN1	9.82e-05	209	164	9	IPR003961
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	ABCC3 FLNC ANKS6 RAPGEF6 SETD1B KMT2B KIF26A MYO9B SREBF1 LAMA5 MCM5 TXNRD2 MAST2 CNTROB RYR1 ANO8 SLC52A3 ZGPAT DIP2A EHBP1L1 INF2 PLA2G4B GLI1 NBEAL2 MARK4 ANKRD34A ANKRD11 NINL COBL CACNA1H SH3BP5L SNX15 KIFC3 D2HGDH SMG6 RAB11FIP3	7.44e-20	1105	168	36	35748872
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	NES RAPGEF6 CDC42EP4 MAP2 ARHGEF5 DPYSL5 SORBS1 BCAR1 MAST2 ARHGEF17 KIAA1671 DLC1 SAMD11 MARK4 ANKRD11 COBL SH3BP5L KLC3	2.19e-07	861	168	18	36931259
Pubmed	Deletion of mesenchymal glucocorticoid receptor attenuates embryonic lung development and abdominal wall closure.	FN1 SFTPA2 SFTPA1 ELN	5.06e-07	14	168	4	23696835
Pubmed	Protein interactome reveals converging molecular pathways among autism disorders.	FN1 KCTD13 PLEKHA4 LAMA5 APP PPP1R13L CNTROB CBS MOAP1 TRIM3 SAFB2 NINL COBL NOTCH3	6.52e-07	560	168	14	21653829
Pubmed	Cytoplasmic Metadherin (MTDH) provides survival advantage under conditions of stress by acting as RNA-binding protein.	ABCC3 FLNC KMT2B FN1 SYNE1 LAMA5 RYR1 ELN NOTCH3	1.08e-06	214	168	9	22199357
Pubmed	Synaptic NMDA receptor activation stimulates alpha-secretase amyloid precursor protein processing and inhibits amyloid-beta production.	MAP2 BACE1 APP	1.10e-06	5	168	3	19357271
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	BDP1 CPAMD8 MAP2 DPYSL5 PEPD BCAR1 APP SHROOM2 ANO8 KIAA1671 PARP10 INF2 SIGIRR SPIN1 ANKRD11 ZFHX2 COBL CACNA1H SYTL1 NOTCH3 CPNE7 SMG6	3.25e-06	1489	168	22	28611215
Pubmed	Mesenchymal nuclear factor I B regulates cell proliferation and epithelial differentiation during lung maturation.	FN1 SFTPA2 SFTPA1 ELN	3.59e-06	22	168	4	21513708
Pubmed	alpha3beta1 Integrin is required for normal development of the epidermal basement membrane.	COL7A1 FN1 LAMA5	3.82e-06	7	168	3	9151677
Pubmed	Myh10 deficiency leads to defective extracellular matrix remodeling and pulmonary disease.	FN1 SFTPA2 GLI1 SFTPA1 ELN	5.36e-06	52	168	5	30389913
Pubmed	Targeted Disruption of Mouse Dip2B Leads to Abnormal Lung Development and Prenatal Lethality.	FN1 TGFBR3 SFTPA2 SFTPA1 ELN	5.89e-06	53	168	5	33153107
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	BDP1 FN1 MAP2 DPYSL5 SORBS1 GPRIN1 DIP2A TRAFD1 NBEAL2 ANKRD11 COBL GALNT5	6.00e-06	497	168	12	36774506
Pubmed	Mouse AMACO, a kidney and skin basement membrane associated molecule that mediates RGD-dependent cell attachment.	COL7A1 FN1 LAMA5	6.09e-06	8	168	3	19651211
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	NES FLNC FN1 KCTD13 ARHGAP23 MAP2 SYNE1 DPYSL5 SORBS1 MTHFS GRM2 ARHGEF17 SHROOM2 RTN1 TRIM3 DIP2A INF2 FGD4 NCAN TNR CNTN1	6.14e-06	1431	168	21	37142655
Pubmed	ΔNp63α Suppresses TGFB2 Expression and RHOA Activity to Drive Cell Proliferation in Squamous Cell Carcinomas.	NES SETD1B PRSS56 USP35 HSF4 D2HGDH TMEM200C	6.23e-06	142	168	7	30232004
Pubmed	Systematic protein-protein interaction mapping for clinically relevant human GPCRs.	KCTD13 SYNE1 BACE1 APP SLC4A3 RTN1 ANO8 NRXN3 INF2 BAZ2A MDC1 MARK4 CACNA1H CNTN1	8.16e-06	697	168	14	28298427
Pubmed	A postnatal switch of CELF and MBNL proteins reprograms alternative splicing in the developing heart.	FLNC FN1 MAP2 SORBS1 RAB11FIP3	1.09e-05	60	168	5	19075228
Pubmed	Transcriptome analysis of mouse stem cells and early embryos.	PAPPA2 FN1 LAMA5 MAST2 TRPM5 LRCH4 SAFB2 PJA1 MOCS1 CNTN1	1.18e-05	363	168	10	14691545
Pubmed	Cystathionine beta-synthase, a key enzyme for homocysteine metabolism, is preferentially expressed in the radial glia/astrocyte lineage of developing mouse CNS.	NES MAP2 CBS	1.30e-05	10	168	3	16160063
Pubmed	A role for FE65 in controlling GnRH-1 neurogenesis.	NES APP NOTCH3	1.78e-05	11	168	3	21228158
Pubmed	LncRNAs-directed PTEN enzymatic switch governs epithelial-mesenchymal transition.	RAPGEF6 SYNE1 EID2 CNTROB ADAMTS15 ANKRD11 NOTCH3	1.86e-05	168	168	7	30631154
Pubmed	High-resolution photocatalytic mapping of SARS-CoV-2 spike interactions on the cell surface.	ABCC1 ANKS6 ARHGAP23 CADM4 ZNHIT6 KCTD3 NOTCH3 CNTN1 SMG6	2.01e-05	307	168	9	37499664
Pubmed	Alternative Selection of β-Site APP-Cleaving Enzyme 1 (BACE1) Cleavage Sites in Amyloid β-Protein Precursor (APP) Harboring Protective and Pathogenic Mutations within the Aβ Sequence.	BACE1 APP	2.32e-05	2	168	2	27687728
Pubmed	Laminin 5 binds the NC-1 domain of type VII collagen.	COL7A1 LAMA5	2.32e-05	2	168	2	9245798
Pubmed	Beta secretase 1-dependent amyloid precursor protein processing promotes excessive vascular sprouting through NOTCH3 signalling.	APP NOTCH3	2.32e-05	2	168	2	32029735
Pubmed	Type VII collagen specifically binds fibronectin via a unique subdomain within the collagenous triple helix.	COL7A1 FN1	2.32e-05	2	168	2	7963647
Pubmed	DNA damage response mediators MDC1 and 53BP1: constitutive activation and aberrant loss in breast and lung cancer, but not in testicular germ cell tumours.	MDC1 TP53BP1	2.32e-05	2	168	2	17546051
Pubmed	Surfactant protein-A binds group B streptococcus enhancing phagocytosis and clearance from lungs of surfactant protein-A-deficient mice.	SFTPA2 SFTPA1	2.32e-05	2	168	2	9922219
Pubmed	Maternal surfactant protein A influences the immunoprotective properties of milk in a murine model.	SFTPA2 SFTPA1	2.32e-05	2	168	2	24858142
Pubmed	Glycosylation of a CNS-specific extracellular matrix glycoprotein, tenascin-R, is dominated by O-linked sialylated glycans and "brain-type" neutral N-glycans.	SIGLEC1 TNR	2.32e-05	2	168	2	10406848
Pubmed	Sex differences in the acute in vivo effects of different human SP-A variants on the mouse alveolar macrophage proteome.	SFTPA2 SFTPA1	2.32e-05	2	168	2	24954098
Pubmed	Activity-induced convergence of APP and BACE-1 in acidic microdomains via an endocytosis-dependent pathway.	BACE1 APP	2.32e-05	2	168	2	23931995
Pubmed	Surfactant protein A modulates neuroinflammation in adult mice upon pulmonary infection.	SFTPA2 SFTPA1	2.32e-05	2	168	2	38964703
Pubmed	Differential Regulation of Human Surfactant Protein A Genes, SFTPA1 and SFTPA2, and Their Corresponding Variants.	SFTPA2 SFTPA1	2.32e-05	2	168	2	34917085
Pubmed	Surfactant protein A integrates activation signal strength to differentially modulate T cell proliferation.	SFTPA2 SFTPA1	2.32e-05	2	168	2	22219327
Pubmed	Surfactant protein A is a principal and oxidation-sensitive microbial permeabilizing factor in the alveolar lining fluid.	SFTPA2 SFTPA1	2.32e-05	2	168	2	15890661
Pubmed	Enhanced lung injury and delayed clearance of Pneumocystis carinii in surfactant protein A-deficient mice: attenuation of cytokine responses and reactive oxygen-nitrogen species.	SFTPA2 SFTPA1	2.32e-05	2	168	2	15385504
Pubmed	A TLR4-interacting SPA4 peptide inhibits LPS-induced lung inflammation.	SFTPA2 SFTPA1	2.32e-05	2	168	2	23475791
Pubmed	Surfactant protein A associated with respiratory distress syndrome in Korean preterm infants: evidence of ethnic difference.	SFTPA2 SFTPA1	2.32e-05	2	168	2	23038062
Pubmed	The enhancement of amyloid precursor protein and beta-site amyloid cleavage enzyme 1 interaction: amyloid-beta production with aging.	BACE1 APP	2.32e-05	2	168	2	20127045
Pubmed	APP knockout mice experience acute mortality as the result of ischemia.	BACE1 APP	2.32e-05	2	168	2	22912719
Pubmed	The in vivo dynamic interplay of MDC1 and 53BP1 at DNA damage-induced nuclear foci.	MDC1 TP53BP1	2.32e-05	2	168	2	22677490
Pubmed	Alzheimer disease Abeta production in the absence of S-palmitoylation-dependent targeting of BACE1 to lipid rafts.	BACE1 APP	2.32e-05	2	168	2	19074428
Pubmed	BACE1 Mediates HIV-Associated and Excitotoxic Neuronal Damage Through an APP-Dependent Mechanism.	BACE1 APP	2.32e-05	2	168	2	29632166
Pubmed	Differential effects of innate immune variants of surfactant protein-A1 (SFTPA1) and SP-A2 (SFTPA2) in airway function after Klebsiella pneumoniae infection and sex differences.	SFTPA2 SFTPA1	2.32e-05	2	168	2	29394894
Pubmed	Nestin and Notch3 collaboratively regulate angiogenesis, collagen production, and endothelial-mesenchymal transition in lung endothelial cells.	NES NOTCH3	2.32e-05	2	168	2	37735673
Pubmed	Role of surfactant protein-A (SP-A) in lung injury in response to acute ozone exposure of SP-A deficient mice.	SFTPA2 SFTPA1	2.32e-05	2	168	2	17307210
Pubmed	Surfactant protein A modulates induction of regulatory T cells via TGF-β.	SFTPA2 SFTPA1	2.32e-05	2	168	2	22474025
Pubmed	Surfactant protein A promotes western diet-induced hepatic steatosis and fibrosis in mice.	SFTPA2 SFTPA1	2.32e-05	2	168	2	38553537
Pubmed	The BACE1-Specific DNA Aptamer A1 Rescues Amyloid-β Pathology and Behavioral Deficits in a Mouse Model of Alzheimer's Disease.	BACE1 APP	2.32e-05	2	168	2	31513457
Pubmed	Surfactant protein A reduces TLR4 and inflammatory cytokine mRNA levels in neonatal mouse ileum.	SFTPA2 SFTPA1	2.32e-05	2	168	2	33510368
Pubmed	Amyloid precursor protein mutation E682K at the alternative β-secretase cleavage β'-site increases Aβ generation.	BACE1 APP	2.32e-05	2	168	2	21500352
Pubmed	Genetic complexity of the human innate host defense molecules, surfactant protein A1 (SP-A1) and SP-A2--impact on function.	SFTPA2 SFTPA1	2.32e-05	2	168	2	19392648
Pubmed	Triptolide treatment reduces Alzheimer's disease (AD)-like pathology through inhibition of BACE1 in a transgenic mouse model of AD.	BACE1 APP	2.32e-05	2	168	2	25481013
Pubmed	Surfactant protein A suppresses lipopolysaccharide-induced IL-10 production by murine macrophages.	SFTPA2 SFTPA1	2.32e-05	2	168	2	11342662
Pubmed	Surfactant protein A-deficient mice are susceptible to group B streptococcal infection.	SFTPA2 SFTPA1	2.32e-05	2	168	2	9126996
Pubmed	A mutation in APP protects against Alzheimer's disease and age-related cognitive decline.	BACE1 APP	2.32e-05	2	168	2	22801501
Pubmed	Replication analysis of genetic association of the NCAN-CILP2 region with plasma lipid levels and non-alcoholic fatty liver disease in Asian and Pacific ethnic groups.	CILP2 NCAN	2.32e-05	2	168	2	26758378
Pubmed	Segregation of the membrane cargoes, BACE1 and amyloid precursor protein (APP) throughout the Golgi apparatus.	BACE1 APP	2.32e-05	2	168	2	35076977
Pubmed	Lung development in the mouse embryo.	SFTPA2 SFTPA1	2.32e-05	2	168	2	2050021
Pubmed	Functions of Aβ, sAPPα and sAPPβ : similarities and differences.	BACE1 APP	2.32e-05	2	168	2	22150401
Pubmed	The histidine composition of the amyloid-β domain, but not the E1 copper binding domain, modulates β-secretase processing of amyloid-β protein precursor in Alzheimer's disease.	BACE1 APP	2.32e-05	2	168	2	25171714
Pubmed	Gene expression profiles of APP and BACE1 in Tg SOD1G93A cortical cells.	BACE1 APP	2.32e-05	2	168	2	19214738
Pubmed	Neuronal protein trafficking associated with Alzheimer disease: from APP and BACE1 to glutamate receptors.	BACE1 APP	2.32e-05	2	168	2	19372755
Pubmed	sAβPPα is a Potent Endogenous Inhibitor of BACE1.	BACE1 APP	2.32e-05	2	168	2	26401691
Pubmed	The direct interaction between 53BP1 and MDC1 is required for the recruitment of 53BP1 to sites of damage.	MDC1 TP53BP1	2.32e-05	2	168	2	18986980
Pubmed	Effects of surfactant protein-A on the interaction of Pneumocystis murina with its host at different stages of the infection in mice.	SFTPA2 SFTPA1	2.32e-05	2	168	2	19335775
Pubmed	Altered surfactant protein A gene expression and protein metabolism associated with repeat exposure to inhaled endotoxin.	SFTPA2 SFTPA1	2.32e-05	2	168	2	12922979
Pubmed	Differences in the alveolar macrophage toponome in humanized SP-A1 and SP-A2 transgenic mice.	SFTPA2 SFTPA1	2.32e-05	2	168	2	33141765
Pubmed	Dynamic assembly and sustained retention of 53BP1 at the sites of DNA damage are controlled by Mdc1/NFBD1.	MDC1 TP53BP1	2.32e-05	2	168	2	16009723
Pubmed	NFkappaB-dependent control of BACE1 promoter transactivation by Abeta42.	BACE1 APP	2.32e-05	2	168	2	18263584
Pubmed	Innate immunity of surfactant protein A in experimental otitis media.	SFTPA2 SFTPA1	2.32e-05	2	168	2	31378117
Pubmed	Altered amyloid-beta metabolism and deposition in genomic-based beta-secretase transgenic mice.	BACE1 APP	2.32e-05	2	168	2	15452128
Pubmed	Immunosuppressed surfactant protein A-deficient mice have increased susceptibility to Pneumocystis carinii infection.	SFTPA2 SFTPA1	2.32e-05	2	168	2	11237812
Pubmed	Embryonic expression pattern of amyloid protein precursor suggests a role in differentiation of specific subsets of neurons.	MAP2 APP	2.32e-05	2	168	2	8207383
Pubmed	Surfactant protein A deficiency exacerbates renal interstitial fibrosis following obstructive injury in mice.	SFTPA2 SFTPA1	2.32e-05	2	168	2	27916681
Pubmed	Surfactant protein A inhibits alveolar macrophage cytokine production by CD14-independent pathway.	SFTPA2 SFTPA1	2.32e-05	2	168	2	12959932
Pubmed	Surfactant protein secreted by the maturing mouse fetal lung acts as a hormone that signals the initiation of parturition.	SFTPA2 SFTPA1	2.32e-05	2	168	2	15044702
Pubmed	Structural comparison of recombinant pulmonary surfactant protein SP-A derived from two human coding sequences: implications for the chain composition of natural human SP-A.	SFTPA2 SFTPA1	2.32e-05	2	168	2	1986781
Pubmed	Surfactant protein A is a required mediator of keratinocyte growth factor after experimental marrow transplantation.	SFTPA2 SFTPA1	2.32e-05	2	168	2	12740217
Pubmed	Surfactant protein-A plays an important role in lung surfactant clearance: evidence using the surfactant protein-A gene-targeted mouse.	SFTPA2 SFTPA1	2.32e-05	2	168	2	18083768
Pubmed	[Microtubule-associated protein 2 and nestin expressions in human embryonic and fetal gastric tissues].	NES MAP2	2.32e-05	2	168	2	22985576
Pubmed	Altered lipid composition in cortical lipid rafts occurs at early stages of sporadic Alzheimer's disease and facilitates APP/BACE1 interactions.	BACE1 APP	2.32e-05	2	168	2	24613671
Pubmed	Distinct effects of recombinant tenascin-R domains in neuronal cell functions and identification of the domain interacting with the neuronal recognition molecule F3/11.	TNR CNTN1	2.32e-05	2	168	2	9081628
Pubmed	The alveolar macrophage toponome of female SP-A knockout mice differs from that of males before and after SP-A1 rescue.	SFTPA2 SFTPA1	2.32e-05	2	168	2	35322074
Pubmed	Biophysical alterations in lipid rafts from human cerebral cortex associate with increased BACE1/AβPP interaction in early stages of Alzheimer's disease.	BACE1 APP	2.32e-05	2	168	2	25147112
Pubmed	Characteristics of surfactant from SP-A-deficient mice.	SFTPA2 SFTPA1	2.32e-05	2	168	2	9700084
Pubmed	Novel role for surfactant protein A in gastrointestinal graft-versus-host disease.	SFTPA2 SFTPA1	2.32e-05	2	168	2	22508928
Pubmed	Relationship between surfactant protein A polymorphisms and allergic rhinitis in a Chinese Han population.	SFTPA2 SFTPA1	2.32e-05	2	168	2	20963503
Pubmed	Genetic and pharmacological evidence of intraneuronal Abeta accumulation in APP transgenic mice.	BACE1 APP	2.32e-05	2	168	2	19683527
Pubmed	Type IV pilus glycosylation mediates resistance of Pseudomonas aeruginosa to opsonic activities of the pulmonary surfactant protein A.	SFTPA2 SFTPA1	2.32e-05	2	168	2	25605768
Pubmed	Role of surfactant protein-A in nitric oxide production and mycoplasma killing in congenic C57BL/6 mice.	SFTPA2 SFTPA1	2.32e-05	2	168	2	12959946
Pubmed	Downregulation of MDC1 and 53BP1 by short hairpin RNA enhances radiosensitivity in laryngeal carcinoma cells.	MDC1 TP53BP1	2.32e-05	2	168	2	25976740
Pubmed	Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE.	BACE1 APP	2.32e-05	2	168	2	10531052
Pubmed	Major Effect of Oxidative Stress on the Male, but Not Female, SP-A1 Type II Cell miRNome.	SFTPA2 SFTPA1	2.32e-05	2	168	2	31354704
Pubmed	Signaling Pathways That Mediate Alveolar Macrophage Activation by Surfactant Protein A and IL-4.	SFTPA2 SFTPA1	2.32e-05	2	168	2	35444643
Pubmed	Mitochondrial γ-secretase participates in the metabolism of mitochondria-associated amyloid precursor protein.	BACE1 APP	2.32e-05	2	168	2	20833873
Pubmed	Lysophosphatidic acid induces increased BACE1 expression and Aβ formation.	BACE1 APP	2.32e-05	2	168	2	23036978
Pubmed	Asynchronous evolutionary origins of Aβ and BACE1.	BACE1 APP	2.32e-05	2	168	2	24361992
Pubmed	Surfactant-associated protein A inhibits LPS-induced cytokine and nitric oxide production in vivo.	SFTPA2 SFTPA1	2.32e-05	2	168	2	10749762
Interaction	TOP3B interactions	ABCC3 FLNC ANKS6 RAPGEF6 SETD1B KMT2B KIF26A MYO9B PLEKHA4 SREBF1 LAMA5 MCM5 TXNRD2 APP MAST2 CNTROB RYR1 ANO8 SLC52A3 ZGPAT DIP2A EHBP1L1 INF2 PLA2G4B GLI1 NBEAL2 MDC1 MARK4 ANKRD34A ANKRD11 SAFB2 NINL COBL CACNA1H SH3BP5L SNX15 KIFC3 D2HGDH TP53BP1 SMG6 RAB11FIP3	2.07e-12	1470	165	41	int:TOP3B
Interaction	NEFL interactions	NES KCTD13 ARHGAP23 MAP2 BCAR1 APP FGD4 CRYBG1 KIFC3 KLC3	8.64e-07	161	165	10	int:NEFL
Interaction	YWHAG interactions	RAPGEF6 FN1 KCTD13 ARHGAP23 MAP2 ARHGEF5 RPS6KA3 DPYSL5 PLEKHA4 MCM5 SORBS1 BCAR1 APP MAST2 ARHGEF17 SHROOM2 KIAA1671 TTBK1 DLC1 SAMD11 MARK4 ANKRD34A ANKRD11 NINL COBL SH3BP5L KLC3	3.33e-06	1248	165	27	int:YWHAG
Interaction	TNR interactions	KCTD13 NCAN SIGLEC1 TNR CNTN1	1.40e-05	38	165	5	int:TNR
Cytoband	Ensembl 112 genes in cytogenetic band chr19p13	CPAMD8 DOHH MYO9B PLK5 ANO8 CILP2 PIK3R2 NCAN SAFB2 NOTCH3 SMIM44	1.85e-04	797	168	11	chr19p13
GeneFamily	Fibronectin type III domain containing	NPHS1 COL7A1 FN1 FNDC1 TNR TNXB CNTN1	6.94e-05	160	114	7	555
GeneFamily	Immunoglobulin like domain containing	A1BG NPHS1 CADM4 CILP2 SIGIRR CNTN1	1.41e-03	193	114	6	594
GeneFamily	Collectins	SFTPA2 SFTPA1	1.72e-03	10	114	2	491
GeneFamily	C2-set domain containing\|Immunoglobulin like domain containing\|Scavenger receptors	NPHS1 CADM4 SIGLEC1	2.04e-03	40	114	3	592
GeneFamily	Paraneoplastic Ma antigens	MOAP1 PNMA3	2.09e-03	11	114	2	671
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	SFTPA2 NCAN SFTPA1	2.19e-03	41	114	3	1298
GeneFamily	ATP binding cassette subfamily C	ABCC3 ABCC1	2.94e-03	13	114	2	807
GeneFamily	Endogenous ligands	FN1 PYY APP NCAN MLN CNTN1	3.92e-03	237	114	6	542
GeneFamily	Ankyrin repeat domain containing	ANKS6 ESPNL PPP1R13L ANKRD34A ANKRD11 NOTCH3	4.33e-03	242	114	6	403
GeneFamily	GATA zinc finger domain containing\|Myb/SANT domain containing	BDP1 ZKSCAN2 ZSCAN20	4.55e-03	53	114	3	532
Coexpression	HEBERT_MATRISOME_TNBC_LUNG_METASTASIS	COL7A1 LAMA5 SFTPA1 ELN TNXB	3.03e-07	23	167	5	M48001
Coexpression	THAKAR_PBMC_INACTIVATED_INFLUENZA_AGE_21_30YO_RESPONDERS_28DY_DN	CDC42EP4 HK3 KCTD13 MYO9B SREBF1 TXNRD2 GRAMD4 PARP10 DIP2A EHBP1L1 KLF13 PLA2G4B PIK3R2 MDC1 LRCH4 ANKRD11 SAFB2 D2HGDH PNMA3	5.49e-06	905	167	19	M40865
Coexpression	NAKAYA_PLASMACYTOID_DENDRITIC_CELL_FLUMIST_AGE_18_50YO_7DY_DN	FLNC COL7A1 CDC42EP4 HK3 FN1 CADM4 PYY MAST2 ARHGEF17 RTN1 EHBP1L1 TRAFD1 NINL ZFHX2 CACNA1H ELN TNXB SLC16A8 NOTCH3	5.85e-06	909	167	19	M41018
Coexpression	LAKE_ADULT_KIDNEY_C5_PROXIMAL_TUBULE_EPITHELIAL_CELLS_STRESS_INFLAM	PAPPA2 KMT2B KIAA1671 PARP10 BAZ2A FGD4 ANKRD11 SAFB2 KIFC3 CNTN1 SMG6 RAB11FIP3	1.60e-05	417	167	12	M39224
Coexpression	YOSHIMURA_MAPK8_TARGETS_UP	OLAH CEBPE KCTD13 MAP2 BCAR1 PPP1R13L CBS SLC4A3 RTN1 TGFBR3 DLC1 PTPRN INF2 FGD4 NCAN DCHS1 SFTPA1 CACNA1H GALNT5 TNR TNXB CNTN1	2.28e-05	1281	167	22	M1884
Coexpression	GSE3982_BASOPHIL_VS_EFF_MEMORY_CD4_TCELL_DN	PAPPA2 DOHH SYNE1 RPS6KA3 TGFBR3 LRCH4 CACNA1H ALOX15B	3.89e-05	196	167	8	M5557
Coexpression	HALLMARK_MITOTIC_SPINDLE	RAPGEF6 CDC42EP4 MYO9B BCAR1 SHROOM2 CNTROB FGD4 MARK4	4.33e-05	199	167	8	M5893
Coexpression	GSE19888_ADENOSINE_A3R_INH_VS_ACT_WITH_INHIBITOR_PRETREATMENT_IN_MAST_CELL_DN	DOHH FN1 BACE1 LAMA5 ARHGEF17 SLC4A3 FNDC1 SFTPA1	4.49e-05	200	167	8	M7323
Coexpression	GSE46606_DAY1_VS_DAY3_CD40L_IL2_IL5_STIMULATED_IRF4MID_BCELL_UP	NPHS1 NES SGCA TP53INP2 TRPM5 ZSCAN20 ST8SIA6 NINL	4.49e-05	200	167	8	M9840
Coexpression	GSE36078_UNTREATED_VS_AD5_INF_MOUSE_LUNG_DC_UP	PYY LAMA5 RYR1 ANO8 ST8SIA6 FGD4 SLC16A8 SPESP1	4.49e-05	200	167	8	M9289
Coexpression	NABA_CORE_MATRISOME	COL7A1 FN1 LAMA5 FNDC1 CILP2 NCAN ELN TNR TNXB	6.20e-05	270	167	9	MM17057
Coexpression	GINESTIER_BREAST_CANCER_ZNF217_AMPLIFIED_DN	KCTD13 MYO9B CNTROB GRAMD4 SLC52A3 KAT8 LRCH4 SAFB2 SH3BP5L HSF4	6.59e-05	338	167	10	M17094
Coexpression	NABA_CORE_MATRISOME	COL7A1 FN1 LAMA5 FNDC1 CILP2 NCAN ELN TNR TNXB	7.14e-05	275	167	9	M5884
CoexpressionAtlas	FacebaseRNAseq_e10.5_Neural Epithelium Overlying Central Eminence_top-relative-expression-ranked_500_k-means-cluster#3	NES MAP2 DPYSL5 RTN1 NRXN3 NCAN ZFHX2 GDF11	3.97e-06	118	165	8	Facebase_RNAseq_e10.5_Neural Epithelium Overlying Central Eminence_500_K3
ToppCell	COPD-Stromal-SMC\|COPD / Disease state, Lineage and Cell class	NES FLNC SGCA SORBS1 HRC LMOD1 CACNA1H ELN MOCS1 NOTCH3	1.69e-09	179	168	10	5c705627bd13a5b2c7b0062fb3d94e4eb1589327
ToppCell	COPD-Stromal-SMC\|World / Disease state, Lineage and Cell class	NES FLNC SGCA SORBS1 HRC LMOD1 CACNA1H ELN MOCS1 NOTCH3	1.69e-09	179	168	10	b2709537ec1b46457ab85261f4cdd354e60a8b29
ToppCell	nucseq-Endothelial-Endothelial_Vascular-Endothelial_capillary-CAP2\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	NES SYNE1 SORBS1 APP SHROOM2 RTN1 KIAA1671 TGFBR3 KCTD3 TNR	2.85e-09	189	168	10	b6b4da51bc7f2c13a2f940540fdc61027d084835
ToppCell	3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts-Myofibroblasts_L.2.3.2.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PAPPA2 FN1 SGCA TGFBR3 FNDC1 SAMD11 GLI1 LMOD1 ELN TNXB	4.25e-09	197	168	10	16758f181ef07c60aee63072e1da9572c5c85414
ToppCell	Bronchial-10x5prime-Stromal-Myofibroblastic-Muscle_smooth_pulmonary\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	FLNC SGCA SORBS1 ARHGEF17 HRC LMOD1 CACNA1H ELN MOCS1 NOTCH3	4.46e-09	198	168	10	705118a5db366b43ffd3389c60e4cb392ad3f2e6
ToppCell	Tracheal-10x5prime-Stromal-Myofibroblastic-Muscle_smooth_airway_ASM\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	FLNC FN1 SGCA SORBS1 FNDC1 NRXN3 LMOD1 CACNA1H NOTCH3 CNTN1	4.46e-09	198	168	10	1e1ea54f0c234f3b6d29064c4881d8a0c0949a75
ToppCell	Adult\|World / Lineage, Cell type, age group and donor	ABCC3 HK3 MYO9B NRXN3 SFTPA2 FGD4 SFTPA1 KIFC3 ALOX15B	4.48e-08	189	168	9	5cd285bfad973125d46d704fec18b21266a63379
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FN1 SORBS1 ARHGEF17 FNDC1 DLC1 SAMD11 LMOD1 ELN NOTCH3	4.68e-08	190	168	9	70c86dd454afb21d4a85db56c5f369d4b342bc97
ToppCell	COVID-19-Heart-EC_+_Pericyte\|Heart / Disease (COVID-19 only), tissue and cell type	CPAMD8 MAP2 LAMA5 ARHGEF17 DLC1 ST8SIA6 CACNA1H MOCS1 NOTCH3	4.68e-08	190	168	9	a21653bfb7bafbc273f94fa7c13bfb48cf8fd562
ToppCell	Fetal_29-31_weeks-Mesenchymal-vascular_smooth_muscle_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	SGCA SORBS1 ARHGEF17 CREB5 LMOD1 CACNA1H ELN MOCS1 NOTCH3	4.68e-08	190	168	9	d6b3a92119b210974a32af3fe9875d60eb02761e
ToppCell	IPF-Stromal-Pericyte\|World / Disease state, Lineage and Cell class	NES SGCA ARHGEF17 DLC1 HRC LMOD1 CACNA1H MOCS1 NOTCH3	5.60e-08	194	168	9	1a41da29d5adaf766a84eff0003b959e4523f7f1
ToppCell	Parenchymal-10x3prime_v2-Stromal-Myofibroblastic\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	FN1 SGCA SORBS1 CREB5 HRC LMOD1 CACNA1H ELN NOTCH3	6.97e-08	199	168	9	9a08c25bb4851ad4ac9db8916422280f71378c2c
ToppCell	LPS_anti-TNF-Mesenchymal_myocytic-Myofibroblastic\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	FN1 SGCA SYNE1 TGFBR3 FNDC1 GLI1 LMOD1 ELN TNXB	6.97e-08	199	168	9	e9820d5fb4e8b46973c4c50ac5db8fb4a1bf603b
ToppCell	Tracheal-10x3prime_v2-Stromal-Myofibroblastic\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	FLNC FN1 SGCA SORBS1 RTN1 HRC LMOD1 CACNA1H NOTCH3	6.97e-08	199	168	9	534dcfe8b65ad92bb8d749d1c7036ad4807e09cd
ToppCell	Parenchymal-10x3prime_v2-Stromal-Myofibroblastic-Muscle_smooth_pulmonary\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	FN1 SGCA SORBS1 CREB5 HRC LMOD1 CACNA1H ELN NOTCH3	6.97e-08	199	168	9	2ed10c5e15c9d5ed0a8bea580842348d5698a07b
ToppCell	cellseq-Mesenchymal-Myocytic-Myocytic_2-SCMF\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	PAPPA2 FN1 SGCA TGFBR3 SAMD11 GLI1 LMOD1 ELN TNXB	7.27e-08	200	168	9	b441b3771fb7d9ee7b7a104afc35e466aace2da2
ToppCell	facs-Heart-RA-18m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MAP2 CNTROB ANO8 FCSK SLC35F3 ZFHX2 LMOD1 NOTCH3	2.93e-07	171	168	8	b54d9d6b03c9c6f28a71cf2ed2bfa9a335bba949
ToppCell	facs-Heart-RA-18m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MAP2 CNTROB ANO8 FCSK SLC35F3 ZFHX2 LMOD1 NOTCH3	2.93e-07	171	168	8	9d825a2e799421af4f2cf4f4dc8e239b5d00476d
ToppCell	390C-Fibroblasts-Fibroblast-B_(Myofibroblast)\|390C / Donor, Lineage, Cell class and subclass (all cells)	ABCC3 FN1 PLEKHA4 BACE1 SLC4A3 CGREF1 ELN GALNT5	3.65e-07	176	168	8	852d3da0907fe87c0ef23d75a63ce07619cf0c54
ToppCell	390C-Fibroblasts-Fibroblast-B_(Myofibroblast)-\|390C / Donor, Lineage, Cell class and subclass (all cells)	ABCC3 FN1 PLEKHA4 BACE1 SLC4A3 CGREF1 ELN GALNT5	3.65e-07	176	168	8	d2df1e435996c51213e88270af9f928e9e09a6f5
ToppCell	Control-Stromal-SMC\|Control / Disease state, Lineage and Cell class	NES SGCA SORBS1 ARHGEF17 LMOD1 CACNA1H ELN NOTCH3	4.15e-07	179	168	8	1378051bc62009eec2dbecf3d5d89baedbeb84eb
ToppCell	Bronchial_Biopsy-Mesenchymal-Smooth_muscle\|Bronchial_Biopsy / Tissue, Lineage and Cell class of Lung Cells from 10X	NES FN1 KIF26A SGCA HRC LMOD1 CACNA1H PNMA3	4.33e-07	180	168	8	7085a851807e6a833965e1366946db0bbc5174e2
ToppCell	Children_(3_yrs)-Mesenchymal-pericyte_cell-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	NES ARHGEF17 SHROOM2 HRC LMOD1 CACNA1H MOCS1 NOTCH3	4.51e-07	181	168	8	451b87ac95154bb80018b8dd245b4a6389d81411
ToppCell	RA-07._Pericyte\|World / Chamber and Cluster_Paper	FN1 MAP2 ARHGEF17 DLC1 LMOD1 CACNA1H MOCS1 NOTCH3	4.71e-07	182	168	8	2075efeae633550fb2eb026d0dfd741c8252482e
ToppCell	Pericytes-HP_01\|World / lung cells shred on cell class, cell subclass, sample id	NES SGCA HRC LMOD1 CACNA1H ELN MOCS1 NOTCH3	5.78e-07	187	168	8	35f25780d113f60bf4c13749013c09612ee4ff41
ToppCell	droplet-Fat-SCAT-30m-Endothelial-Cd36+\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NES KIF26A SYNE1 LAMA5 SORBS1 KIAA1671 DLC1 NOTCH3	6.02e-07	188	168	8	e901a9bdf00b8e91806f445af66647373bf62661
ToppCell	IPF-Stromal-SMC\|World / Disease state, Lineage and Cell class	SGCA SORBS1 HRC LMOD1 CACNA1H ELN MOCS1 NOTCH3	6.02e-07	188	168	8	b66264e8f8d536ed2beec31e6746c687718f239b
ToppCell	facs-Trachea-18m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SGCA SORBS1 CILP2 TRPM5 FGF20 HRC LMOD1 NOTCH3	6.02e-07	188	168	8	340f0e3e65c7a00d82d26621ff37107458bebc41
ToppCell	normal_Lung-Fibroblasts-Smooth_muscle_cells\|normal_Lung / Location, Cell class and cell subclass	NES SGCA FNDC1 HRC LMOD1 CACNA1H ELN NOTCH3	6.02e-07	188	168	8	fd70fb89570f014d1299c60fe017dc09f24e57c6
ToppCell	facs-Trachea-18m-Mesenchymal-myofibroblast\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SGCA SORBS1 CILP2 TRPM5 FGF20 HRC LMOD1 NOTCH3	6.02e-07	188	168	8	9d384c0934f1461bc37b1f83e0877d7bee2116ee
ToppCell	droplet-Fat-SCAT-30m-Endothelial-endothelial_cell\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NES KIF26A SYNE1 LAMA5 SORBS1 KIAA1671 DLC1 NOTCH3	6.02e-07	188	168	8	5cf060bb8adaefa9964187195d67993c1248ef47
ToppCell	facs-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l39\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SGCA LAMA5 SORBS1 HRC LMOD1 CACNA1H GDF11 NOTCH3	6.02e-07	188	168	8	a5e7a363fbd5ae4d9312cf6f9941413d6a5c0b4d
ToppCell	facs-Trachea-nan-3m-Mesenchymal-smooth_muscle_cell_of_trachea\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MAP2 SGCA CADM4 SORBS1 FGF20 HRC LMOD1 NOTCH3	6.02e-07	188	168	8	794fc1d9a726945c42f7eac221eed938309b47a9
ToppCell	droplet-Fat-SCAT-30m-Endothelial\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NES KIF26A SYNE1 LAMA5 SORBS1 KIAA1671 DLC1 NOTCH3	6.02e-07	188	168	8	449f9602df3c83b2110eb479a00d428d1b55b423
ToppCell	IPF-Stromal-SMC\|IPF / Disease state, Lineage and Cell class	SGCA SORBS1 HRC LMOD1 CACNA1H ELN MOCS1 NOTCH3	6.02e-07	188	168	8	e98b24c0de41285f01f7ac194ff0a1b59fd5c333
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MAP2 SORBS1 ARHGEF17 NRXN3 DLC1 LMOD1 ELN NOTCH3	6.26e-07	189	168	8	7fbe855bfdb47d35e040b04a80fe4b729a3764e8
ToppCell	LPS_only-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_3\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	NES SGCA DPYSL5 FNDC1 HRC LMOD1 ELN NOTCH3	6.26e-07	189	168	8	975e7aa3b862a8b07c2ab8426a14f5cc54998aca
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MAP2 SORBS1 ARHGEF17 NRXN3 DLC1 LMOD1 ELN NOTCH3	6.26e-07	189	168	8	06b35abecd29f902cf251fcc1f6ad33db7ab08a2
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SORBS1 ARHGEF17 EHBP1L1 DLC1 LMOD1 CACNA1H ELN NOTCH3	6.26e-07	189	168	8	127ad2ba3e794df8cce2eee3e4171bccb5aad51b
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SORBS1 ARHGEF17 EHBP1L1 DLC1 LMOD1 CACNA1H ELN NOTCH3	6.26e-07	189	168	8	2cfb4d12f75678d1619f4743838a0e954bd57761
ToppCell	droplet-Kidney-nan-21m-Epithelial-Stroma____kidney_mesangial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	A1BG NES SGCA ARHGEF17 ANKRD34A HRC LMOD1 NOTCH3	6.52e-07	190	168	8	e04f47705851563515b6a66a2634cf7a574f7bda
ToppCell	droplet-Limb_Muscle-Pre-Sort-18m-Mesenchymal-smooth_muscle_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAMA5 SORBS1 ARHGEF17 SLC4A3 TP53INP2 LMOD1 CACNA1H NOTCH3	6.78e-07	191	168	8	8e8beb8e8a3b33cac83d3f7ce915a71e3654fdab
ToppCell	droplet-Trachea-3m-Epithelial-airway_epithelial-neuroendocrine_cell-neuroendocrine\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SGCA CADM4 SORBS1 HRC LMOD1 CACNA1H TMEM200C NOTCH3	6.78e-07	191	168	8	72f1ddc09080dbfea8d51294cbf7f9d4925f9cc0
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	FN1 SORBS1 NRXN3 DLC1 LMOD1 CACNA1H ELN NOTCH3	6.78e-07	191	168	8	04c4d454b57e29a8d1dcdeb4678ce71bdc29b77b
ToppCell	droplet-Trachea-3m-Epithelial-airway_epithelial-neuroendocrine_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SGCA CADM4 SORBS1 HRC LMOD1 CACNA1H TMEM200C NOTCH3	6.78e-07	191	168	8	6e7f589efc997f32175e0789c5ea7ca46e1389b8
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PAPPA2 ABCC3 COL7A1 APP CREB5 NRXN3 FGD4 COBL	6.78e-07	191	168	8	9032aa974aa1b7b1095b8d1b58dcb087358a5001
ToppCell	droplet-Trachea-nan-3m-Epithelial-neuroendocrine_cell\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SGCA CADM4 SORBS1 HRC LMOD1 CACNA1H TMEM200C NOTCH3	6.78e-07	191	168	8	3ce403e0beedb544edeb3ae6eb30267040d00c21
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PAPPA2 ABCC3 COL7A1 APP CREB5 NRXN3 FGD4 COBL	6.78e-07	191	168	8	5717809a1476c20f65bce722c5a57cff92ee0d7a
ToppCell	Transplant_Alveoli_and_parenchyma-Mesenchymal-Smooth_muscle\|Transplant_Alveoli_and_parenchyma / Tissue, Lineage and Cell class of Lung Cells from 10X	MAP2 SGCA SORBS1 HRC LMOD1 CACNA1H MOCS1 NOTCH3	7.34e-07	193	168	8	9104b572d9c3c99080e4b7455993fbb944bf117d
ToppCell	3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FN1 SGCA TGFBR3 FNDC1 SAMD11 LMOD1 ELN TNXB	7.63e-07	194	168	8	8fae8061b350336299aa81f378e07deadbd55123
ToppCell	3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FN1 SGCA TGFBR3 FNDC1 SAMD11 LMOD1 ELN TNXB	7.63e-07	194	168	8	4d7d24390fdb379f943ddcc70a63f23955e10163
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FN1 MAP2 SORBS1 FNDC1 DLC1 LMOD1 ELN NOTCH3	7.63e-07	194	168	8	ebb038f94f49f5c655578d1b018676e10c6b7e3c
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MAP2 SGCA ARHGEF17 DLC1 HRC LMOD1 ELN NOTCH3	7.93e-07	195	168	8	e10b21e4dba4483efc4c82d6e395524246ca14a8
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(nasal)-Club_(nasal)_L.0.2.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ARHGAP23 ARHGEF5 CADM4 SREBF1 PPP1R13L CLCA2 SYTL1 NOTCH3	7.93e-07	195	168	8	24d226f89dd337c22728688e4b40ca082a0e1fe1
ToppCell	Bronchial-NucSeq-Stromal-Fibroblastic-Fibro_myofibroblast\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SLC4A3 TGFBR3 PARP10 SAMD11 LMOD1 USP35 ELN TNXB	7.93e-07	195	168	8	f5e91ce20a7ce528dc4c1a968c7bf096bf45c528
ToppCell	356C-Fibroblasts-Fibroblast-K_(Pericytes)\|356C / Donor, Lineage, Cell class and subclass (all cells)	FLNC FN1 SGCA SORBS1 LMOD1 CACNA1H ELN NOTCH3	8.24e-07	196	168	8	a5cc4f76e1a3825aaccba9a686d7da6f7e4300ff
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FN1 MAP2 SORBS1 ARHGEF17 DLC1 LMOD1 ELN NOTCH3	8.24e-07	196	168	8	b8759e6231e0254797d6c30930407b79440c57bb
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FN1 SORBS1 FNDC1 DLC1 LMOD1 ELN TNXB NOTCH3	8.24e-07	196	168	8	fa445f4240c521cf04eb2e2f79a5c55fda31209a
ToppCell	PND01-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PAPPA2 NES CREB5 TGFBR3 FNDC1 NRXN3 ELN CPNE7	8.24e-07	196	168	8	9d7b631f24a19a7dc7a28f28525d4019fc8fcf8a
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FN1 SORBS1 FNDC1 DLC1 LMOD1 ELN TNXB NOTCH3	8.24e-07	196	168	8	802f61e78a9a1030a86c4a980c398a73cd4d1574
ToppCell	356C-Fibroblasts-Fibroblast-K_(Pericytes)-\|356C / Donor, Lineage, Cell class and subclass (all cells)	FLNC FN1 SGCA SORBS1 LMOD1 CACNA1H ELN NOTCH3	8.24e-07	196	168	8	476812fc1422aca8010d771eff11fa6081f15a2d
ToppCell	3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-tracheobronchial_smooth_muscle_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FLNC SGCA SORBS1 HRC LMOD1 CACNA1H MOCS1 NOTCH3	8.24e-07	196	168	8	208ddedd29e1b9ca89cbb9b527c2e193a44cada2
ToppCell	IPF-Stromal-Pericyte\|IPF / Disease state, Lineage and Cell class	SGCA ARHGEF17 DLC1 HRC LMOD1 CACNA1H MOCS1 NOTCH3	8.24e-07	196	168	8	8b6ff47ce5291d223f5e639fc45cd9267f418256
ToppCell	10x_3'_v2v3-Non-neoplastic-Vascular-Mural_cell-Pericyte-C\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	COL7A1 FN1 SGCA DLC1 ST8SIA6 HRC LMOD1 NOTCH3	8.24e-07	196	168	8	12d9028f90c057c6e5cff00301793fa550e86c5a
ToppCell	PND01-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PAPPA2 NES CREB5 TGFBR3 FNDC1 NRXN3 ELN CPNE7	8.56e-07	197	168	8	7d97c2d51a543c02d679e9257b22d0581e73a11d
ToppCell	Bronchial-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_pulmonary\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	FLNC FN1 SORBS1 CREB5 LMOD1 CACNA1H ELN NOTCH3	8.56e-07	197	168	8	bf0520a94ebb1d2f94de9f526d17e0b0e8fe7052
ToppCell	Bronchial_Biopsy-Mesenchymal-Smooth_muscle\|Mesenchymal / Tissue, Lineage and Cell class of Lung Cells from 10X	KIF26A SGCA TRIM3 KIAA1671 HRC LMOD1 CACNA1H NOTCH3	8.56e-07	197	168	8	98f0184a09563a544f0c2d4df22c9db2fbc95019
ToppCell	PND01-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF-SCMF_mature\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PAPPA2 NES CREB5 TGFBR3 FNDC1 NRXN3 ELN CPNE7	8.56e-07	197	168	8	671d6b5effbac2dd71d18f48d23c523738db1828
ToppCell	distal-mesenchymal-Vascular_Smooth_Muscle-2\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	COL7A1 SGCA HRC LMOD1 CACNA1H ELN MOCS1 NOTCH3	8.56e-07	197	168	8	da653dc7d216e202f390e5ab0245f243e3ed213b
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-Pericytes-Contractile_pericyte_(PLN+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MAP2 SGCA SORBS1 ARHGEF17 HRC LMOD1 CACNA1H NOTCH3	8.56e-07	197	168	8	d16bb765afdc02406ffd7ce6a75bae72b66db66c
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-Pericytes\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MAP2 SGCA SORBS1 ARHGEF17 HRC LMOD1 CACNA1H NOTCH3	8.56e-07	197	168	8	68c23c23b6924892f4c238cf2f5abc7927e04fbc
ToppCell	Parenchymal-NucSeq-Stromal-Myofibroblastic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	FLNC FN1 SORBS1 EHBP1L1 LMOD1 CACNA1H ELN NOTCH3	8.89e-07	198	168	8	bd42c03e384e64f61b02618cf1a5440033bb04b2
ToppCell	5'-Adult-Distal_Rectal\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ABCC3 FN1 SREBF1 APP TGFBR3 NBEAL2 ELN TNXB	8.89e-07	198	168	8	db26c20321f9ab102d6484f22ddb2bde684067b1
ToppCell	390C-Fibroblasts-Fibroblast-K_(Pericytes)\|390C / Donor, Lineage, Cell class and subclass (all cells)	NES FLNC FN1 SGCA PLEKHA4 SORBS1 LMOD1 NOTCH3	8.89e-07	198	168	8	c82a151f9f1477d4a401457173b8d72af776c137
ToppCell	390C-Fibroblasts-Fibroblast-K_(Pericytes)-\|390C / Donor, Lineage, Cell class and subclass (all cells)	NES FLNC FN1 SGCA PLEKHA4 SORBS1 LMOD1 NOTCH3	8.89e-07	198	168	8	dc63b56bb6291e527b172d603569376286262845
ToppCell	LPS_anti-TNF-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	PPP1R13L NRXN3 PLA2G4B NBEAL2 COBL KIFC3 GALNT5 KLC3	9.24e-07	199	168	8	d43c605a4ff221cf78d91678c15d2ad20f831c7f
ToppCell	Tracheal-10x3prime_v2-Stromal-Myofibroblastic-Muscle_smooth_pulmonary\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	FN1 SGCA SORBS1 RTN1 HRC LMOD1 CACNA1H NOTCH3	9.24e-07	199	168	8	056a28c36cd58dc695a5ae6f29b62135d6aad819
ToppCell	Tracheal-10x5prime-Stromal-Myofibroblastic-Muscle_smooth_pulmonary\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	NES FN1 MAP2 SGCA SORBS1 LMOD1 CACNA1H NOTCH3	9.24e-07	199	168	8	8ff0fdcbe9661b013913731ec8b53d84836ca865
ToppCell	Parenchymal-10x5prime-Stromal-Myofibroblastic\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	SGCA ARHGEF17 HRC LMOD1 CACNA1H ELN MOCS1 NOTCH3	9.24e-07	199	168	8	20f760d92c351a1dac4cc0a424c443ea03a179fe
ToppCell	Bronchial-10x5prime-Stromal-Myofibroblastic\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	SGCA SORBS1 ARHGEF17 HRC LMOD1 CACNA1H MOCS1 NOTCH3	9.24e-07	199	168	8	ad75e5e26c37a97331164d7f77235ebd9a933a44
ToppCell	Parenchymal-10x5prime-Stromal-Myofibroblastic-Muscle_smooth_pulmonary\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	SGCA ARHGEF17 HRC LMOD1 CACNA1H ELN MOCS1 NOTCH3	9.24e-07	199	168	8	7c272a1aa7f3e931ad5d20809719d85b3bce4cb0
ToppCell	distal-2-mesenchymal-Airway_Smooth_Muscle\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	FLNC SGCA HRC LMOD1 CACNA1H ELN MOCS1 NOTCH3	9.24e-07	199	168	8	af226a6c50747dad9ca696463e715913b3ac17c0
ToppCell	Parenchymal-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_pulmonary\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	FLNC FN1 SORBS1 EHBP1L1 LMOD1 CACNA1H ELN NOTCH3	9.24e-07	199	168	8	b1753474152b82a0b811b9878c890a359e14919a
ToppCell	Bronchial-10x5prime-Stromal-Pericyte-Muscle_pericyte_pulmonary\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	NES SGCA ARHGEF17 HRC LMOD1 CACNA1H MOCS1 NOTCH3	9.59e-07	200	168	8	12326cc6f0af24bacba9493dc79e7c7347db2f41
ToppCell	Control_saline-Mesenchymal_myocytic-Myofibroblastic\|Control_saline / Treatment groups by lineage, cell group, cell type	SGCA SYNE1 TGFBR3 FNDC1 GLI1 LMOD1 ELN TNXB	9.59e-07	200	168	8	9d5b3c2dcfa55d50acc2ce2c319d51aa525d4cd1
ToppCell	LPS_anti-TNF-Mesenchymal_myocytic-Myofibroblastic-Myofibroblast\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	FN1 SGCA SYNE1 TGFBR3 FNDC1 GLI1 LMOD1 ELN	9.59e-07	200	168	8	c596a53c0b63c9deaac7d99fcbdd94ecfa96b86c
ToppCell	Bronchial-10x5prime-Stromal-Pericyte\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	NES SGCA ARHGEF17 HRC LMOD1 CACNA1H MOCS1 NOTCH3	9.59e-07	200	168	8	362706445edb33b313684efe50b1f44f5f816e67
ToppCell	Parenchymal-10x5prime-Stromal-Pericyte-Muscle_pericyte_pulmonary\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	NES SGCA ARHGEF17 HRC LMOD1 CACNA1H MOCS1 NOTCH3	9.59e-07	200	168	8	f9bc22ff17bb1c751e6b05bca3f403836f33459a
ToppCell	Parenchymal-10x5prime-Stromal-Pericyte\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	NES SGCA ARHGEF17 HRC LMOD1 CACNA1H MOCS1 NOTCH3	9.59e-07	200	168	8	0a7640db28c708003d5da2d19eb651f6fedfd710
ToppCell	LPS_only-Mesenchymal_myocytic\|LPS_only / Treatment groups by lineage, cell group, cell type	SGCA SYNE1 PLEKHA4 ARHGEF17 TGFBR3 FNDC1 LMOD1 NOTCH3	9.59e-07	200	168	8	8bc9923f82bfb836e2f524204c92050edeae8ca5
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	A1BG ESPNL ZKSCAN2 SORBS1 LMOD1 SNX15 CNTN1	2.80e-06	162	168	7	68c40d12689cc1b6c797e6e48173f0110f8144e4
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-kidney_interstitial_fibroblast_5\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	A1BG ESPNL ZKSCAN2 SORBS1 LMOD1 SNX15 CNTN1	2.80e-06	162	168	7	735fa3f77b31a4189e431d05c326403c18cbbffb
ToppCell	3'-GW_trimst-1-SmallIntestine-Epithelial-neuro-epithelial-L_cells_(PYY+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ERICH3 RPS6KA3 PYY TRPM5 PTPRN MLN TNR	3.56e-06	168	168	7	0f736d58cb0ff042fa3ce58e36bde37b6976f8fc
ToppCell	PND03-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC-VSMC_prolif\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MCM5 CLCA2 HRC LMOD1 ELN NOTCH3 PNMA3	4.32e-06	173	168	7	5c55e1e27e9e3e77600d378cc87b51cc73907527
ToppCell	E16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC-VSMC_prolif\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FN1 CLCA2 ADAMTS15 HRC LMOD1 ELN NOTCH3	4.49e-06	174	168	7	778e0317c0c63fa4efd74114feb760975b819d92
ToppCell	E16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_prolif\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PAPPA2 FLNC PLEKHA4 FNDC1 TRPM5 SYTL1 CNTN1	4.49e-06	174	168	7	4da79da7a09ee1e345102c5331675ebcdbe56171
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FN1 ARHGAP23 MYO9B SYNE1 ARHGEF17 NOTCH3 SPESP1	4.66e-06	175	168	7	12f5fd83c7710fc0c77406f765d9cbd133433b8b
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SGCA ESPNL SORBS1 ARHGEF17 NRXN3 LMOD1 ELN	4.66e-06	175	168	7	d52794426f2703a80e91ae0a8ff2d8e0ce4aa4a8
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SGCA ESPNL SORBS1 ARHGEF17 NRXN3 LMOD1 ELN	4.66e-06	175	168	7	454f03e6109d65f5db08dbb41ecc19ffb6bbc4e0
ToppCell	Entopeduncular-Endothelial-MURAL-M1(Rgs5Acta2)-M1_3\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	PAPPA2 SGCA GLI1 HRC LMOD1 NOTCH3	4.74e-06	114	168	6	108cc5b04cc7c59310eb55dc2c44ae2b8e0b05e4
Computational	Heparin binding.	FN1 APP TGFBR3 NCAN	1.17e-04	28	99	4	MODULE_385
Drug	radicicol; Down 200; 0.1uM; PC3; HG-U133A	ABCC3 KMT2B SREBF1 MCM5 EHBP1L1 TRAFD1 PTPRN BAZ2A GDF11 NOTCH3	2.11e-06	199	166	10	484_DN
Drug	0179445-0000 [211246-22-9]; Down 200; 10uM; PC3; HT_HG-U133A	ABCC3 SORBS1 APP SLC4A3 NRXN3 KAT8 MARK4 COBL CBX8	1.07e-05	189	166	9	3733_DN
Drug	5230742; Up 200; 17uM; MCF7; HT_HG-U133A_EA	LAMA5 TRAFD1 DLC1 SIGIRR SAFB2 CACNA1H MOCS1 CPNE7 SMG6	1.11e-05	190	166	9	970_UP
Drug	colchicine; Up 200; 1uM; SKMEL5; HG-U133A	SETD1B BAZ2A SIGIRR PIK3R2 MARK4 NINL SNX15 CNTN1 CPNE7	1.11e-05	190	166	9	630_UP
Drug	Xylazine [7361-61-7]; Down 200; 18.2uM; PC3; HT_HG-U133A	SYNE1 CREB5 TRAFD1 DLC1 MARK4 KIFC3 MOCS1 NOTCH3 CPNE7	1.49e-05	197	166	9	4066_DN
Drug	Natamycin [7681-93-8]; Down 200; 6uM; MCF7; HT_HG-U133A	ABCC3 NES CDC42EP4 KMT2B TRAFD1 INF2 NBEAL2 MIPEP SNX15	1.68e-05	200	166	9	7167_DN
Drug	Austricine [10180-88-8]; Down 200; 14.2uM; HL60; HT_HG-U133A	PAPPA2 COL7A1 DOHH CDC42EP4 MAST2 NBEAL2 ZFHX2 ELN CNTN1	1.68e-05	200	166	9	2157_DN
Disease	Colorectal Carcinoma	ABCC3 ABCC1 FLNC COL7A1 CPAMD8 HK3 FN1 MAP2 SYNE1 KCNH4 ZNHIT6 DLC1 DCHS1 ADAMTS15 CNTN1	8.23e-06	702	162	15	C0009402
Disease	neutrophil count	PAPPA2 NES CPAMD8 CEBPE ARHGAP23 PEPD MAST2 CBS CREB5 ZGPAT DIP2A TRAFD1 PRPF4 NBEAL2 MARK4 MIPEP ANKRD34A ANKRD11 TNR TNXB SMG6	2.40e-05	1382	162	21	EFO_0004833
Disease	pulse pressure measurement	PAPPA2 FN1 PEPD PYY LAMA5 BCAR1 MAST2 CREB5 KCNH4 TGFBR3 FCSK DIP2A FNDC1 CILP2 TTBK1 DLC1 ADAMTS15 ANKRD11 ELN NOTCH3 SMG6	2.66e-05	1392	162	21	EFO_0005763
Disease	glucose-dependent insulinotropic peptide measurement, glucose tolerance test	PAPPA2 ARHGEF17 ST8SIA6	5.66e-05	14	162	3	EFO_0004307, EFO_0008464
Disease	Malignant neoplasm of breast	ABCC1 COL7A1 HK3 FN1 SYNE1 RPS6KA3 SORBS1 BCAR1 SHROOM2 CLCA2 GLI1 ANKRD34A GALNT5 PCDH8 NOTCH3 TP53BP1	2.95e-04	1074	162	16	C0006142
Disease	level of leukocyte immunoglobulin-like receptor subfamily B member 4 in blood serum	SFTPA2 SFTPA1	2.96e-04	5	162	2	OBA_2042200
Disease	level of prosaposin in blood serum	SFTPA2 SFTPA1	2.96e-04	5	162	2	OBA_2044552
Disease	congenital diaphragmatic hernia (biomarker_via_orthology)	SFTPA2 SFTPA1 ELN	3.02e-04	24	162	3	DOID:3827 (biomarker_via_orthology)
Disease	serum alanine aminotransferase measurement	RAPGEF6 PEPD LAMA5 TP53INP2 CREB5 FCSK ZGPAT CILP2 TRAFD1 KLF13 PIK3R2 NCAN MARK4 USP35	3.29e-04	869	162	14	EFO_0004735
Disease	Schizophrenia	A1BG RAPGEF6 MYO9B ACSM1 SREBF1 BACE1 GRM2 CBS NRXN3 PLA2G4B KAT8 NCAN PCDH8 TNXB	3.85e-04	883	162	14	C0036341
Disease	sexual dimorphism measurement	PAPPA2 COL7A1 RAPGEF6 KMT2B KCTD13 MYO9B BACE1 TP53INP2 CREB5 ZGPAT PARP10 EHBP1L1 NRXN3 ANKRD11 SMIM44 TP53BP1	4.07e-04	1106	162	16	EFO_0021796
Disease	Abnormality of vision	FCSK KAT8	4.43e-04	6	162	2	C4025846
Disease	newborn respiratory distress syndrome (biomarker_via_orthology)	SFTPA2 SFTPA1	4.43e-04	6	162	2	DOID:12716 (biomarker_via_orthology)
Disease	ANEURYSM, INTRACRANIAL BERRY, 1 (disorder)	TGFBR3 ELN	4.43e-04	6	162	2	C1862932
Disease	Hyalinosis, Segmental Glomerular	NPHS1 FN1 INF2	4.81e-04	28	162	3	C0086432
Disease	tonsillectomy risk measurement	RAPGEF6 PARP10 TRAFD1 KLF13 FGF20 MDC1 TNXB	6.08e-04	260	162	7	EFO_0007924
Disease	arachidonate 15-lipoxygenase B measurement	CNTROB ALOX15B	6.18e-04	7	162	2	EFO_0801391
Disease	newborn respiratory distress syndrome (is_implicated_in)	SFTPA2 SFTPA1	6.18e-04	7	162	2	DOID:12716 (is_implicated_in)
Disease	laurylcarnitine measurement	ABCC1 PCDH8	6.18e-04	7	162	2	EFO_0021041
Disease	Alzheimer's disease 1 (implicated_via_orthology)	APP KLC3	6.18e-04	7	162	2	DOID:0080348 (implicated_via_orthology)
Disease	leukocyte immunoglobulin-like receptor subfamily B member 4 measurement	SFTPA2 SFTPA1	8.21e-04	8	162	2	EFO_0801768
Disease	Colorectal Neoplasms	ABCC3 ABCC1 FLNC COL7A1 CPAMD8 SYNE1 DLC1	8.82e-04	277	162	7	C0009404
Disease	Focal glomerulosclerosis	NPHS1 FN1 INF2	1.02e-03	36	162	3	C0017668
Disease	Hyperhomocysteinemia	NPHS1 CBS	1.59e-03	11	162	2	C0598608
Disease	complement C1q tumor necrosis factor-related protein 1 measurement	SFTPA2 SFTPA1	1.91e-03	12	162	2	EFO_0801493
Disease	granulins measurement	SFTPA2 SFTPA1	1.91e-03	12	162	2	EFO_0008141
Disease	Familial idiopathic steroid-resistant nephrotic syndrome	NPHS1 INF2	2.25e-03	13	162	2	cv:C4273714
Disease	Diverticular Bleeding	SLC35F3 ELN	2.25e-03	13	162	2	C4505353
Disease	Diverticular Diseases	SLC35F3 ELN	2.25e-03	13	162	2	C4317009
Disease	iron deficiency anemia (biomarker_via_orthology)	FN1 APP	2.25e-03	13	162	2	DOID:11758 (biomarker_via_orthology)
Disease	platelet crit	KIF26A MYO9B LAMA5 ZGPAT TRAFD1 NCAN MARK4 DCHS1 PJA1 CBX8 NOTCH3 SMIM44 SMG6	2.37e-03	952	162	13	EFO_0007985
Disease	Hamman-Rich syndrome	SFTPA2 SFTPA1	2.61e-03	14	162	2	C0085786
Disease	Impaired cognition	APP NOTCH3	2.61e-03	14	162	2	C0338656
Disease	bacterial pneumonia (biomarker_via_orthology)	SFTPA2 SFTPA1	2.61e-03	14	162	2	DOID:874 (biomarker_via_orthology)
Disease	FEV/FEC ratio	MAP2 ZKSCAN2 ARHGEF17 TGFBR3 DLC1 SFTPA2 ANKRD11 LMOD1 SFTPA1 ELN PJA1 TNXB D2HGDH SMIM44 SMG6	3.24e-03	1228	162	15	EFO_0004713
Disease	Hepatomegaly	A1BG ABCC3 PEPD	3.28e-03	54	162	3	C0019209
Disease	Peripheral Nervous System Diseases	ABCC1 GLI1 CACNA1H	3.28e-03	54	162	3	C4721453
Disease	Glioblastoma Multiforme	FN1 RPS6KA3 NOTCH3 TP53BP1	3.32e-03	111	162	4	C1621958
Disease	Cardiovascular Abnormalities	ANKS6 KAT8	3.42e-03	16	162	2	C0243050
Disease	immature platelet fraction	MYO9B SORBS1 BAZ2A MARK4	3.66e-03	114	162	4	EFO_0009187
Disease	physical activity measurement, body mass index	ERICH3 MAST2 NRXN3 LMOD1	3.66e-03	114	162	4	EFO_0004340, EFO_0008002
Disease	Dementia	APP NOTCH3	3.86e-03	17	162	2	C0497327
Disease	muscular dystrophy (is_implicated_in)	SGCA SYNE1	3.86e-03	17	162	2	DOID:9884 (is_implicated_in)
Disease	urate measurement	COL7A1 DPYSL5 ZKSCAN2 VARS2 APP TP53INP2 GRAMD4 ZNHIT6 GLI1 SPIN1 NINL SMIM44	4.00e-03	895	162	12	EFO_0004531
Disease	urate measurement, spine bone mineral density	PAPPA2 PRR35 MARK4	4.02e-03	58	162	3	EFO_0004531, EFO_0007701
Disease	venous thromboembolism	PAPPA2 ABCC1 DPYSL5 PEPD DLC1 MIPEP SMG6 RAB11FIP3	4.03e-03	460	162	8	EFO_0004286
Disease	diastolic blood pressure, systolic blood pressure	CNTROB TP53INP2 CREB5 KIAA1671 DLC1 CLCA2 ADAMTS15 MLN ELN CPNE7	4.04e-03	670	162	10	EFO_0006335, EFO_0006336
Disease	Feeding difficulties	FCSK KAT8	4.33e-03	18	162	2	C0232466
Disease	X-11470 measurement	VARS2 TNXB	4.82e-03	19	162	2	EFO_0021241
Disease	chronic obstructive pulmonary disease (is_implicated_in)	ABCC1 SFTPA1 ELN	5.07e-03	63	162	3	DOID:3083 (is_implicated_in)
Disease	angina pectoris	BCAR1 EHBP1L1 MDC1 SMG6	5.07e-03	125	162	4	EFO_0003913
Disease	Familial Idiopathic Pulmonary Fibrosis	SFTPA2 SFTPA1	5.33e-03	20	162	2	C4721952
Disease	basophil count	ABCC1 CEBPE CREB5 RYR1 CILP2 PIK3R2 MARK4 TNXB	5.38e-03	483	162	8	EFO_0005090

Protein segments in the cluster

Peptide	Gene	Start	Entry
RDGSVPLPESTRELG	KCTD13	101	Q8WZ19
EDRIDEPDGLGPRRS	SMG6	306	Q86US8
TEKREIPPGIERGAE	ERICH3	826	Q5RHP9
GAPLGLRLPRETDEE	BACE1	36	P56817
DGSIVIPPSEVEGRD	SLC4A3	606	P48751
EETGRREISPEENGP	BDP1	1146	A6H8Y1
AELEEVGPSRRVGEE	BDP1	1761	A6H8Y1
VEAETVPEERARGDP	ANKRD11	2221	Q6UB99
RAVAVKEEPRGPEGS	CEBPE	116	Q15744
GELRPEVVEDEVPRS	SH3BP5L	16	Q7L8J4
EVEPVDARPAADRGL	APP	636	P05067
RERVLPPEVADGGVV	BCAR1	391	P56945
VAGPGREPLELEVAV	BCAR1	446	P56945
EEEEESIAAVPGRRG	BAZ2A	1056	Q9UIF9
SGTIRQGEELPPEEL	ARHGEF5	201	Q12774
EAPGTGKETAPERRE	GRM2	701	Q14416
RDSEELRDPAGPGTL	GRAMD4	46	Q6IC98
EARRESLDPVQEPGG	CGREF1	196	Q99674
PPAEERDVGRLREAL	DOHH	151	Q9BU89
AGGSEPEREVVVPIR	ADAMTS15	16	Q8TE58
PTEGRPGIERLTAEF	ANKRD34A	261	Q69YU3
EREPPAILFRRAGGE	ANO8	671	Q9HCE9
DGEDRPVRSRSEGPD	PYY	81	P10082
GYPEGVERIDEPGLR	PEPD	381	P12955
EPVGSQEDGPRLRAV	RAB11FIP3	196	O75154
SGEDEVLLGARPRPR	ABCC3	281	O15438
GEPTEPEIEARPRLA	SLC16A8	486	O95907
PGLPGRRSAERALEE	LRCH4	26	O75427
GRDAVLRCEGPIPDV	A1BG	416	P04217
PGLREEDTDTPGLRR	ARHGEF17	26	Q96PE2
LVEQRAEPEEPGATR	ARHGEF17	866	Q96PE2
PTGGRRRRVVDEDPD	CREB5	361	Q02930
IPQPGEGDVREEALS	MTHFS	111	P49914
DKEGERLEGVAAPPR	NPHS1	581	O60500
GTPVPELVVTGELDR	DCHS1	201	Q96JQ0
DIDGLVPTRDERGQP	ESPNL	431	Q6ZVH7
GPVEGRDTAELPART	PTPRN	391	Q16849
AERVGPERGPLERET	MDC1	821	Q14676
ESPSPRLGRGLELAE	KIAA1671	401	Q9BY89
VADEVTRPRPSGEEV	MCM5	106	P33992
PARGEPEVTVEIGET	KAT8	46	Q9H7Z6
GPDDTPEEILARIGS	RPS6KA3	621	P51812
RVFSGRESPEPGEEE	MOAP1	166	Q96BY2
LDVVDPDGSVPVGLR	LMOD1	36	P29536
GTRIPLEVPVDEDVG	PCDH8	151	O95206
ELDVRAQDRGPGPRA	PCDH8	321	O95206
IGPVLPLEERGAETE	FGD4	161	Q96M96
EEEAGRRAPEGPRSL	PPM1N	31	Q8N819
VLGPTGVAEPVEVRD	FLNC	1481	Q14315
EPRARRELAPEVIGS	NOTCH3	1566	Q9UM47
PRESRPAEVPAEGLV	EHBP1L1	1226	Q8N3D4
DLAGPEGSRRPEVEA	PLK5	161	Q496M5
PAPEVEELARRLGEA	NES	171	P48681
EPLRSPEVGDEEALR	NES	676	P48681
PDLSPRIVDGIEDSG	KCNH4	821	Q9UQ05
GAAAVLRGEEEPRPS	KIF26A	1391	Q9ULI4
TVEPKREREGGPIRE	GLI1	411	P08151
GPIREESRLTVPEGA	GLI1	421	P08151
AGLGPERLSPEELVR	KLC3	11	Q6P597
ATPGAPRIEQLDGVD	KMT2B	2051	Q9UMN6
VRGVLDLDRPGEPAG	KMT2B	2331	Q9UMN6
PGVRRTPEEAAAGEV	PLA2G4B	711	P0C869
PGATLPDVGLELEVR	LAMA5	3536	O15230
GDPVLRGVAAPVERA	PDF	71	Q9HBH1
EPGVRPCEVGLVVDT	HK3	231	P52790
EEEARRPRGEDGKPV	INF2	946	Q27J81
GGEPLIRPDVVDIVA	MOCS1	126	Q9NZB8
TPRDPGQEGELERAA	PRR35	316	P0CG20
RALREAAGPVGPALE	PIK3R2	196	O00459
LTENPAGLRGAVEEP	PAPPA2	111	Q9BXP8
VTREDFLVGRPPELG	FCSK	276	Q8N0W3
RIPVARILGDPEEES	CBX8	336	Q9HC52
RPRPGVTEATITGLE	FN1	2041	P02751
LIPVDRAIEDTRPAG	GALNT5	471	Q7Z7M9
KEEREPAIALAPRGG	FNDC1	1221	Q4ZHG4
EPEGEAEDRVTAGPR	CPAMD8	1801	Q8IZJ3
DDGVLRSPRGEPALR	CPNE7	561	Q9UBL6
PPGGLRIEDIRATSV	CNTN1	606	Q12860
GEDLAVGAPPRGEVI	COBL	941	O75128
VGSRLPPGAERIALE	FASTKD1	766	Q53R41
LELRPRGEAAEGPAA	GDF11	16	O95390
GVRLSPEPGREGVRD	ZNHIT6	21	Q9NWK9
GILEERSPAFRGPDR	CDC42EP4	316	Q9H3Q1
RIIGVDPEGSILAEP	CBS	276	P35520
PERAEAVGETLTLPG	CADM4	266	Q8NFZ8
ETVTLEDGRIGERPE	DPY19L4	451	Q7Z388
RRLLEPGAAEPAERG	ANKS6	26	Q68DC2
PGIPAREELARETGL	DUX3	146	Q96PT4
DVPQAEVGRGRREPA	EID2	21	Q8N6I1
REIPDRGPLGLESGD	HSF4	356	Q9ULV5
RVADEPERIGGPEVT	MARK4	626	Q96L34
GRQRLEERTGPAGPE	MAST2	41	Q6P0Q8
AATPTLPRVEERRDG	KLF13	41	Q9Y2Y9
REEGPAAVIVARTDP	COL7A1	671	Q02388
SGEEAARAIPRELPV	CRYBG1	151	Q9Y4K1
EALTVAIRRPPDLGG	DIP2A	671	Q14689
ARGSEGRVEPKAEPV	GPRIN1	741	Q7Z2K8
LLGTPGPEDEARAER	B3GNT6	156	Q6ZMB0
IALERPDIDPGSTER	CACNA1H	1311	O95180
GVRRSLSPELREGDP	ELN	616	P15502
PGRESRVEEPLENDI	OLAH	61	Q9NV23
EEAIRISEDPARDGP	RYR1	2381	P21817
ISEDPARDGPGIRRD	RYR1	2386	P21817
EGESVTVLRRDGPEE	PPP1R13L	781	Q8WUF5
TGEETVRLGFPVDPR	KCTD3	171	Q9Y597
PLIPGAGSERREEDS	CNTROB	121	Q8N137
ERIVPGGVVTDPEAL	D2HGDH	71	Q8N465
TGPEGIEISRPEELE	DPYSL5	211	Q9BPU6
DGPEAEAVREARVPL	PRSS56	236	P0CW18
EAEAGVAVEVRGLPP	PARP10	6	Q53GL7
EPDSIERRPVKDGGG	ABCC1	626	P33527
LPEDIRTRGVEDIPG	ALOX15B	456	O15296
GERPPLLGERRSAAE	FGF20	31	Q9NP95
AEERAPSRRGLAEPG	RTN1	506	Q16799
IDEAPQERLRETEGP	SYTL1	141	Q8IYJ3
LTGRPGAELTLERDP	VARS2	566	Q5ST30
GDVDLTRLPEGPVDS	RAPGEF6	216	Q8TEU7
RPREENDLGPAGTVD	SLC52A3	266	Q9NQ40
GREGEEKRNEVAIPP	TRAFD1	136	O14545
REDVIPSGIPQAEDR	SYNE1	3556	Q8NF91
RREPEEPEGAVAARA	TMEM200C	436	A6NKL6
PEVSRGEEGRISESP	PLEKHA4	181	Q9H4M7
GEPITLFGEGPAERR	PRPF4	116	O43172
RVRPVTKEDGEGPEA	KIFC3	451	Q9BVG8
TEPGIRRVPGASEVI	NRXN3	541	Q9HDB5
SSLEPRRPEEAGAEV	NBEAL2	41	Q6ZNJ1
GPDRESLEGLEVAPR	PNMA3	341	Q9UL41
EGEILSAEGPPVREL	NCAN	376	O14594
GRVPEGRALDSEVDP	SIGIRR	336	Q6IA17
PADAPGRARILVEES	ST8SIA6	26	P61647
PREELPSAVRAEEGQ	SHROOM2	946	Q13796
RAPERELGTGEQPLS	SAMD11	626	Q96NU1
RRPARPLELDSGGEE	SETD1B	1021	Q9UPS6
EAIPPGPRGRDEVTE	SETD1B	1616	Q9UPS6
ENLVRSVPSGEPGRE	SPESP1	41	Q6UW49
EAPPGEELEPRTRVG	RNF217	126	Q8TC41
ARAGGRIAVPRNPEE	SFTPA2	156	Q8IWL1
RREERAEVGAPLSPD	HRC	551	P23327
PGARELPLLGTERDA	NINL	936	Q9Y2I6
EPSEIPERRDSGVGA	DLC1	976	Q96QB1
LTKVEGEERPRDSPG	SLC35F3	21	Q8IY50
ARAGGRIAVPRNPEE	SFTPA1	156	Q8IWL2
TSALDRGGRVPLPIE	SGCA	176	Q16586
GGAVAELEPRPTRRE	SREBF1	1071	P36956
ESAVVGSPDPIRGEV	ACSM1	496	Q08AH1
TAEDPGARERGPDLL	ANHX	206	E9PGG2
GPVEARVTFVDPRDL	CILP2	601	Q8IUL8
RSPAEAEARGPEGLL	CLEC2L	31	P0C7M8
PETGDPVTLRLLDDG	CLCA2	646	Q9UQC9
PLPEEGEERRRLGAE	TTBK1	576	Q5TCY1
RATDGPGEAVALPRL	ZSCAN20	416	P17040
EPEAGGTRAPEERSR	ZFHX2	1556	Q9C0A1
EELVEAPRAQGDRGP	TRPM5	701	Q9NZQ8
ERRGLFGVPELSAPE	MIPEP	61	Q99797
RSGEEGPVDPAEPIR	MLN	56	P12872
PDGDLSEGELTPARR	TP53INP2	131	Q8IXH6
PAEREPGEVVDSLVG	SPIN1	201	Q9Y657
RALEPPAEDRGDEVV	ARHGAP23	476	Q9P227
RPREGPEAELGSSRV	USP35	926	Q9P2H5
APEDLRRVSEPDLTG	SORBS1	251	Q9BX66
PVEGSLREVSVPGLD	TNXB	1821	P22105
PAERRGLEELEVPVD	SNX15	161	Q9NRS6
VAPPEDLRVAGISDR	TNR	326	Q92752
PRELRPSLTGEDLEG	SMIM44	81	A0A286YF18
VVKREPAEQPGDGER	SAFB2	291	Q14151
RVVAEPGLDVPEGAA	SIGLEC1	1446	Q9BZZ2
TRETAVPGPLGIEDI	TP53BP1	1411	Q12888
SILPPRRGVSGDRDE	MAP2	1546	P11137
VVGETEAPGVRPDPR	nan	311	Q3C1V9
AIGDVVEGRPELTPI	TXNRD2	356	Q9NNW7
RVGELPEVTELVSGP	LINC01356	21	Q8N9X3
EEVPSPSRQERGGIE	ZKSCAN2	596	Q63HK3
PAEETLELGRLVSPG	TP53TG3	66	Q9ULZ0
SEEEGAGPVERPPVR	PJA1	126	Q8NG27
EGDGILPPLRTEATE	ZGPAT	261	Q8N5A5
PGLREPEEVQGSVDI	TGFBR3	436	Q03167
ELRAEITGPDGTRLP	TRIM3	361	O75382
LDDTRPGDGRRVTPL	INSYN2B	236	A6NMK8
TGREEGLEVGPPEVL	MYO9B	421	Q13459