Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	phospholipid-hydroperoxide glutathione peroxidase activity	GPX1 GPX2	2.84e-05	4	44	2	GO:0047066
GeneOntologyMolecularFunction	3-chloroallyl aldehyde dehydrogenase activity	ALDH1A2 ALDH1A3	9.90e-05	7	44	2	GO:0004028
GeneOntologyMolecularFunction	thyroid hormone binding	ALDH1A3 CTSH	9.90e-05	7	44	2	GO:0070324
GeneOntologyMolecularFunction	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	ALDH1A2 ALDH1A3 OGDH	1.61e-04	48	44	3	GO:0016620
GeneOntologyMolecularFunction	oxidoreductase activity	ALDH1A2 ALDH1A3 OGDH KDM6A MICAL2 KDM4B GPX1 GPX2	2.35e-04	766	44	8	GO:0016491
GeneOntologyMolecularFunction	oxidoreductase activity, acting on the aldehyde or oxo group of donors	ALDH1A2 ALDH1A3 OGDH	2.55e-04	56	44	3	GO:0016903
GeneOntologyMolecularFunction	single-stranded DNA endodeoxyribonuclease activity	SETMAR POLQ	3.64e-04	13	44	2	GO:0000014
GeneOntologyMolecularFunction	retinal dehydrogenase activity	ALDH1A2 ALDH1A3	4.25e-04	14	44	2	GO:0001758
GeneOntologyMolecularFunction	aldehyde dehydrogenase (NAD+) activity	ALDH1A2 ALDH1A3	4.89e-04	15	44	2	GO:0004029
GeneOntologyMolecularFunction	aldehyde dehydrogenase [NAD(P)+] activity	ALDH1A2 ALDH1A3	6.32e-04	17	44	2	GO:0004030
GeneOntologyMolecularFunction	intracellularly gated calcium channel activity	RYR1 ITPR1	7.10e-04	18	44	2	GO:0015278
GeneOntologyMolecularFunction	damaged DNA binding	ZNF28 POLQ DDB1	8.40e-04	84	44	3	GO:0003684
GeneOntologyMolecularFunction	nitric-oxide synthase binding	DNM3 DNM2	1.07e-03	22	44	2	GO:0050998
GeneOntologyMolecularFunction	protein serine/threonine kinase binding	DNM3 DNM2	1.27e-03	24	44	2	GO:0120283
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	ZNF480 ZNF28 ZBTB1 KDM6A ZNF277 NOTCH2 ZNF829 CARF PROX1	1.56e-03	1271	44	9	GO:0000987
GeneOntologyMolecularFunction	histone H3 demethylase activity	KDM6A KDM4B	1.73e-03	28	44	2	GO:0141052
GeneOntologyMolecularFunction	glutathione peroxidase activity	GPX1 GPX2	1.73e-03	28	44	2	GO:0004602
GeneOntologyMolecularFunction	histone demethylase activity	KDM6A KDM4B	2.12e-03	31	44	2	GO:0032452
GeneOntologyMolecularFunction	ligand-gated calcium channel activity	RYR1 ITPR1	2.12e-03	31	44	2	GO:0099604
GeneOntologyMolecularFunction	protein demethylase activity	KDM6A KDM4B	2.26e-03	32	44	2	GO:0140457
GeneOntologyMolecularFunction	intracellularly ligand-gated monoatomic ion channel activity	RYR1 ITPR1	2.40e-03	33	44	2	GO:0005217
GeneOntologyMolecularFunction	microfilament motor activity	MYO7A MYO7B	3.17e-03	38	44	2	GO:0000146
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ZNF480 ZNF28 ZBTB1 KDM6A ZNF277 ZNF829 CARF PROX1 ZNF554	3.98e-03	1459	44	9	GO:0000977
GeneOntologyMolecularFunction	demethylase activity	KDM6A KDM4B	4.23e-03	44	44	2	GO:0032451
GeneOntologyMolecularFunction	DNA endonuclease activity	SETMAR POLQ	4.23e-03	44	44	2	GO:0004520
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ZNF480 ZNF28 ZBTB1 KDM6A ZNF277 ZNF829 CARF PROX1	5.28e-03	1244	44	8	GO:0000978
GeneOntologyBiologicalProcess	embryonic organ morphogenesis	IFT140 ALDH1A2 ALDH1A3 MYO7A KDM6A MICAL2 NOTCH2 PROX1	5.60e-07	351	43	8	GO:0048562
GeneOntologyBiologicalProcess	embryonic camera-type eye development	IFT140 ALDH1A2 ALDH1A3 PROX1	2.29e-06	45	43	4	GO:0031076
GeneOntologyBiologicalProcess	morphogenesis of an epithelium	CD151 ALDH1A2 ALDH1A3 CTSH KDM6A MICAL2 NOTCH2 SEMA3E PROX1	4.22e-06	619	43	9	GO:0002009
GeneOntologyBiologicalProcess	epithelium development	IFT140 CD151 ALDH1A2 ALDH1A3 AKAP9 MYO7A CTSH KDM6A MICAL2 NOTCH2 SEMA3E GPX1 PROX1	5.58e-06	1469	43	13	GO:0060429
GeneOntologyBiologicalProcess	protein homooligomerization	ALDH1A2 ALDH1A3 POLQ ZBTB1 RYR1 ITPR1	6.69e-06	224	43	6	GO:0051260
GeneOntologyBiologicalProcess	embryonic organ development	IFT140 ALDH1A2 ALDH1A3 MYO7A KDM6A MICAL2 NOTCH2 PROX1	1.78e-05	561	43	8	GO:0048568
GeneOntologyBiologicalProcess	tissue morphogenesis	CD151 ALDH1A2 ALDH1A3 CTSH KDM6A MICAL2 NOTCH2 SEMA3E PROX1	1.97e-05	750	43	9	GO:0048729
GeneOntologyBiologicalProcess	protein homotetramerization	ALDH1A2 ALDH1A3 RYR1 ITPR1	1.98e-05	77	43	4	GO:0051289
GeneOntologyBiologicalProcess	epithelial tube morphogenesis	ALDH1A2 CTSH KDM6A MICAL2 NOTCH2 SEMA3E PROX1	2.40e-05	421	43	7	GO:0060562
GeneOntologyBiologicalProcess	protein complex oligomerization	ALDH1A2 ALDH1A3 POLQ ZBTB1 RYR1 ITPR1	3.24e-05	296	43	6	GO:0051259
GeneOntologyBiologicalProcess	animal organ morphogenesis	IFT140 ALDH1A2 ALDH1A3 MYO7A CTSH KDM6A MICAL2 RYR1 NOTCH2 ITPR1 PROX1	4.23e-05	1269	43	11	GO:0009887
GeneOntologyBiologicalProcess	heart morphogenesis	ALDH1A2 KDM6A MICAL2 RYR1 NOTCH2 PROX1	5.09e-05	321	43	6	GO:0003007
GeneOntologyBiologicalProcess	protein tetramerization	ALDH1A2 ALDH1A3 RYR1 ITPR1	8.94e-05	113	43	4	GO:0051262
GeneOntologyBiologicalProcess	embryonic morphogenesis	IFT140 ALDH1A2 ALDH1A3 MYO7A KDM6A MICAL2 NOTCH2 PROX1	9.73e-05	713	43	8	GO:0048598
GeneOntologyBiologicalProcess	sensory organ development	IFT140 ALDH1A2 ALDH1A3 MYO7A MYO7B OTOGL NOTCH2 PROX1	1.15e-04	730	43	8	GO:0007423
GeneOntologyBiologicalProcess	response to symbiont	GPX1 GPX2	1.18e-04	8	43	2	GO:0009608
GeneOntologyBiologicalProcess	response to symbiotic bacterium	GPX1 GPX2	1.18e-04	8	43	2	GO:0009609
GeneOntologyBiologicalProcess	epithelial cell proliferation involved in liver morphogenesis	NOTCH2 ITPR1 PROX1	1.20e-04	46	43	3	GO:0072575
GeneOntologyBiologicalProcess	hepatocyte proliferation	NOTCH2 ITPR1 PROX1	1.20e-04	46	43	3	GO:0072574
GeneOntologyBiologicalProcess	circulatory system development	IFT140 ALDH1A2 CTSH KDM6A MICAL2 RYR1 NOTCH2 DNM2 SEMA3E GPX1 PROX1	1.34e-04	1442	43	11	GO:0072359
GeneOntologyBiologicalProcess	gland development	ALDH1A2 ALDH1A3 ZBTB1 NOTCH2 GPX1 ITPR1 PROX1	1.41e-04	558	43	7	GO:0048732
GeneOntologyBiologicalProcess	liver morphogenesis	NOTCH2 ITPR1 PROX1	1.45e-04	49	43	3	GO:0072576
GeneOntologyBiologicalProcess	heart development	IFT140 ALDH1A2 KDM6A MICAL2 RYR1 NOTCH2 DNM2 PROX1	1.47e-04	757	43	8	GO:0007507
GeneOntologyBiologicalProcess	forebrain neuron differentiation	OGDH SEMA3E PROX1	1.84e-04	53	43	3	GO:0021879
GeneOntologyBiologicalProcess	limbic system development	ALDH1A3 OGDH SEMA3E PROX1	2.10e-04	141	43	4	GO:0021761
GeneOntologyBiologicalProcess	synaptic vesicle budding from presynaptic endocytic zone membrane	DNM3 DNM2	2.31e-04	11	43	2	GO:0016185
GeneOntologyBiologicalProcess	determination of left/right symmetry	IFT140 ALDH1A2 MICAL2 NOTCH2	2.94e-04	154	43	4	GO:0007368
GeneOntologyBiologicalProcess	embryonic camera-type eye formation	ALDH1A3 PROX1	3.26e-04	13	43	2	GO:0060900
GeneOntologyBiologicalProcess	forebrain generation of neurons	OGDH SEMA3E PROX1	3.37e-04	65	43	3	GO:0021872
GeneOntologyBiologicalProcess	left/right pattern formation	IFT140 ALDH1A2 MICAL2 NOTCH2	3.56e-04	162	43	4	GO:0060972
GeneOntologyBiologicalProcess	retinoic acid biosynthetic process	ALDH1A2 ALDH1A3	3.80e-04	14	43	2	GO:0002138
GeneOntologyBiologicalProcess	determination of bilateral symmetry	IFT140 ALDH1A2 MICAL2 NOTCH2	3.82e-04	165	43	4	GO:0009855
GeneOntologyBiologicalProcess	specification of symmetry	IFT140 ALDH1A2 MICAL2 NOTCH2	3.82e-04	165	43	4	GO:0009799
GeneOntologyBiologicalProcess	response to purine-containing compound	AKAP9 ADSS2 RYR1 ITPR1	3.91e-04	166	43	4	GO:0014074
GeneOntologyBiologicalProcess	diterpenoid biosynthetic process	ALDH1A2 ALDH1A3	4.38e-04	15	43	2	GO:0016102
GeneOntologyBiologicalProcess	synaptic vesicle budding	DNM3 DNM2	4.38e-04	15	43	2	GO:0070142
GeneOntologyBiologicalProcess	eye development	IFT140 ALDH1A2 ALDH1A3 MYO7A NOTCH2 PROX1	4.52e-04	480	43	6	GO:0001654
GeneOntologyBiologicalProcess	visual system development	IFT140 ALDH1A2 ALDH1A3 MYO7A NOTCH2 PROX1	4.67e-04	483	43	6	GO:0150063
GeneOntologyBiologicalProcess	heart looping	ALDH1A2 MICAL2 NOTCH2	4.74e-04	73	43	3	GO:0001947
GeneOntologyBiologicalProcess	sensory system development	IFT140 ALDH1A2 ALDH1A3 MYO7A NOTCH2 PROX1	5.10e-04	491	43	6	GO:0048880
GeneOntologyBiologicalProcess	determination of heart left/right asymmetry	ALDH1A2 MICAL2 NOTCH2	5.98e-04	79	43	3	GO:0061371
GeneOntologyBiologicalProcess	embryonic heart tube morphogenesis	ALDH1A2 MICAL2 NOTCH2	6.20e-04	80	43	3	GO:0003143
GeneOntologyBiologicalProcess	nose development	ALDH1A3 PROX1	6.36e-04	18	43	2	GO:0043584
GeneOntologyBiologicalProcess	regulation of Golgi organization	AKAP9 DNM2	6.36e-04	18	43	2	GO:1903358
GeneOntologyBiologicalProcess	positive regulation of apoptotic process	USP7 ALDH1A2 ALDH1A3 CTSH NOTCH2 DNM2 ITPR1	6.50e-04	718	43	7	GO:0043065
GeneOntologyBiologicalProcess	sensory perception of sound	MYO7A MYO7B OTOGL GPX1	7.59e-04	198	43	4	GO:0007605
GeneOntologyBiologicalProcess	positive regulation of programmed cell death	USP7 ALDH1A2 ALDH1A3 CTSH NOTCH2 DNM2 ITPR1	7.71e-04	739	43	7	GO:0043068
GeneOntologyBiologicalProcess	chromatin remodeling	USP7 SETMAR ZBTB1 DDB1 KDM6A KDM4B GPX1	7.83e-04	741	43	7	GO:0006338
GeneOntologyBiologicalProcess	neural tube development	IFT140 ALDH1A2 KDM6A PROX1	8.17e-04	202	43	4	GO:0021915
GeneOntologyBiologicalProcess	liver development	ALDH1A2 NOTCH2 ITPR1 PROX1	8.17e-04	202	43	4	GO:0001889
GeneOntologyBiologicalProcess	eye morphogenesis	ALDH1A3 MYO7A NOTCH2 PROX1	8.48e-04	204	43	4	GO:0048592
GeneOntologyBiologicalProcess	hepaticobiliary system development	ALDH1A2 NOTCH2 ITPR1 PROX1	8.63e-04	205	43	4	GO:0061008
GeneOntologyBiologicalProcess	terpenoid biosynthetic process	ALDH1A2 ALDH1A3	8.69e-04	21	43	2	GO:0016114
GeneOntologyBiologicalProcess	retinal metabolic process	ALDH1A2 ALDH1A3	8.69e-04	21	43	2	GO:0042574
GeneOntologyBiologicalProcess	diencephalon development	ALDH1A2 OGDH SEMA3E	8.74e-04	90	43	3	GO:0021536
GeneOntologyBiologicalProcess	striatum development	ALDH1A3 OGDH	9.55e-04	22	43	2	GO:0021756
GeneOntologyBiologicalProcess	response to vitamin	ALDH1A2 KDM6A GPX1	1.19e-03	100	43	3	GO:0033273
GeneOntologyBiologicalProcess	response to organic cyclic compound	ALDH1A2 AKAP9 ADSS2 KDM6A RYR1 DNM2 GPX1 ITPR1	1.28e-03	1048	43	8	GO:0014070
GeneOntologyBiologicalProcess	inflammatory response to antigenic stimulus	NOTCH2 GPX1 GPX2	1.29e-03	103	43	3	GO:0002437
GeneOntologyBiologicalProcess	embryonic heart tube development	ALDH1A2 MICAL2 NOTCH2	1.29e-03	103	43	3	GO:0035050
GeneOntologyBiologicalProcess	translesion synthesis	POLQ ZBTB1	1.34e-03	26	43	2	GO:0019985
GeneOntologyBiologicalProcess	sensory perception of mechanical stimulus	MYO7A MYO7B OTOGL GPX1	1.50e-03	238	43	4	GO:0050954
GeneOntologyBiologicalProcess	regulation of organelle organization	USP7 IFT140 SETMAR AKAP9 VPS13C DDHD1 DNM2 GPX1 PROX1	1.53e-03	1342	43	9	GO:0033043
GeneOntologyBiologicalProcess	subpallium development	ALDH1A3 OGDH	1.55e-03	28	43	2	GO:0021544
GeneOntologyBiologicalProcess	forebrain neuron development	OGDH SEMA3E	1.78e-03	30	43	2	GO:0021884
GeneOntologyBiologicalProcess	camera-type eye development	IFT140 ALDH1A2 ALDH1A3 NOTCH2 PROX1	1.85e-03	426	43	5	GO:0043010
GeneOntologyBiologicalProcess	inner ear development	ALDH1A3 MYO7A OTOGL PROX1	1.87e-03	253	43	4	GO:0048839
GeneOntologyBiologicalProcess	tube morphogenesis	ALDH1A2 CTSH KDM6A MICAL2 NOTCH2 SEMA3E GPX1 PROX1	2.01e-03	1125	43	8	GO:0035239
GeneOntologyBiologicalProcess	embryonic camera-type eye morphogenesis	ALDH1A3 PROX1	2.02e-03	32	43	2	GO:0048596
GeneOntologyBiologicalProcess	maintenance of location in cell	AKAP9 VPS13C RYR1 ITPR1	2.04e-03	259	43	4	GO:0051651
GeneOntologyBiologicalProcess	tube development	IFT140 ALDH1A2 CTSH KDM6A MICAL2 NOTCH2 SEMA3E GPX1 PROX1	2.07e-03	1402	43	9	GO:0035295
Domain	Dynamin_central	DNM3 DNM2	7.72e-05	6	43	2	IPR000375
Domain	RIH_assoc	RYR1 ITPR1	7.72e-05	6	43	2	PF08454
Domain	RIH_assoc-dom	RYR1 ITPR1	7.72e-05	6	43	2	IPR013662
Domain	GED	DNM3 DNM2	7.72e-05	6	43	2	SM00302
Domain	RIH_dom	RYR1 ITPR1	7.72e-05	6	43	2	IPR000699
Domain	Ins145_P3_rcpt	RYR1 ITPR1	7.72e-05	6	43	2	IPR014821
Domain	Ryanodine_recept-rel	RYR1 ITPR1	7.72e-05	6	43	2	IPR015925
Domain	GED	DNM3 DNM2	7.72e-05	6	43	2	PS51388
Domain	-	RYR1 ITPR1	7.72e-05	6	43	2	1.25.10.30
Domain	Dynamin_M	DNM3 DNM2	7.72e-05	6	43	2	PF01031
Domain	Dynamin_GTPase_CS	DNM3 DNM2	7.72e-05	6	43	2	IPR019762
Domain	GED_dom	DNM3 DNM2	7.72e-05	6	43	2	IPR020850
Domain	GED	DNM3 DNM2	7.72e-05	6	43	2	PF02212
Domain	RYDR_ITPR	RYR1 ITPR1	7.72e-05	6	43	2	PF01365
Domain	GED	DNM3 DNM2	7.72e-05	6	43	2	IPR003130
Domain	Ins145_P3_rec	RYR1 ITPR1	7.72e-05	6	43	2	PF08709
Domain	G_DYNAMIN_1	DNM3 DNM2	1.08e-04	7	43	2	PS00410
Domain	GPX_AS	GPX1 GPX2	1.08e-04	7	43	2	IPR029759
Domain	DYNc	DNM3 DNM2	1.08e-04	7	43	2	SM00053
Domain	GLUTATHIONE_PEROXID_2	GPX1 GPX2	1.44e-04	8	43	2	PS00763
Domain	GLUTATHIONE_PEROXID_1	GPX1 GPX2	1.44e-04	8	43	2	PS00460
Domain	Glutathione_peroxidase	GPX1 GPX2	1.44e-04	8	43	2	IPR000889
Domain	GLUTATHIONE_PEROXID_3	GPX1 GPX2	1.44e-04	8	43	2	PS51355
Domain	GPX_CS	GPX1 GPX2	1.44e-04	8	43	2	IPR029760
Domain	GSHPx	GPX1 GPX2	1.44e-04	8	43	2	PF00255
Domain	MYTH4	MYO7A MYO7B	1.84e-04	9	43	2	PS51016
Domain	MyTH4_dom	MYO7A MYO7B	1.84e-04	9	43	2	IPR000857
Domain	MyTH4	MYO7A MYO7B	1.84e-04	9	43	2	PF00784
Domain	MyTH4	MYO7A MYO7B	1.84e-04	9	43	2	SM00139
Domain	MIR	RYR1 ITPR1	2.30e-04	10	43	2	PS50919
Domain	MIR	RYR1 ITPR1	2.30e-04	10	43	2	PF02815
Domain	MIR	RYR1 ITPR1	2.30e-04	10	43	2	SM00472
Domain	MIR_motif	RYR1 ITPR1	2.30e-04	10	43	2	IPR016093
Domain	G_DYNAMIN_dom	DNM3 DNM2	4.63e-04	14	43	2	IPR030381
Domain	G_DYNAMIN_2	DNM3 DNM2	4.63e-04	14	43	2	PS51718
Domain	Dynamin_GTPase	DNM3 DNM2	5.33e-04	15	43	2	IPR001401
Domain	Dynamin_N	DNM3 DNM2	5.33e-04	15	43	2	PF00350
Domain	Dynamin_SF	DNM3 DNM2	5.33e-04	15	43	2	IPR022812
Domain	Ald_DH_CS_GLU	ALDH1A2 ALDH1A3	6.09e-04	16	43	2	IPR029510
Domain	Ald_DH_CS_CYS	ALDH1A2 ALDH1A3	6.89e-04	17	43	2	IPR016160
Domain	ALDEHYDE_DEHYDR_GLU	ALDH1A2 ALDH1A3	7.74e-04	18	43	2	PS00687
Domain	ALDEHYDE_DEHYDR_CYS	ALDH1A2 ALDH1A3	7.74e-04	18	43	2	PS00070
Domain	Ald_DH_C	ALDH1A2 ALDH1A3	8.64e-04	19	43	2	IPR016163
Domain	Ald_DH_N	ALDH1A2 ALDH1A3	8.64e-04	19	43	2	IPR016162
Domain	Ald_DH/histidinol_DH	ALDH1A2 ALDH1A3	8.64e-04	19	43	2	IPR016161
Domain	-	ALDH1A2 ALDH1A3	8.64e-04	19	43	2	3.40.605.10
Domain	Aldedh	ALDH1A2 ALDH1A3	8.64e-04	19	43	2	PF00171
Domain	Aldehyde_DH_dom	ALDH1A2 ALDH1A3	8.64e-04	19	43	2	IPR015590
Domain	-	ALDH1A2 ALDH1A3	8.64e-04	19	43	2	3.40.309.10
Domain	JmjC	KDM6A KDM4B	1.38e-03	24	43	2	PF02373
Domain	JMJC	KDM6A KDM4B	2.46e-03	32	43	2	PS51184
Domain	JmjC_dom	KDM6A KDM4B	2.46e-03	32	43	2	IPR003347
Domain	JmjC	KDM6A KDM4B	2.61e-03	33	43	2	SM00558
Domain	P-loop_NTPase	DNM3 N4BP2L2 ADSS2 POLQ MYO7A MYO7B DNM2	2.99e-03	848	43	7	IPR027417
Domain	Myosin_head_motor_dom	MYO7A MYO7B	3.45e-03	38	43	2	IPR001609
Domain	MYOSIN_MOTOR	MYO7A MYO7B	3.45e-03	38	43	2	PS51456
Domain	Myosin_head	MYO7A MYO7B	3.45e-03	38	43	2	PF00063
Domain	MYSc	MYO7A MYO7B	3.45e-03	38	43	2	SM00242
Pathway	REACTOME_SYNTHESIS_OF_15_EICOSATETRAENOIC_ACID_DERIVATIVES	GPX1 GPX2	8.93e-05	6	35	2	M27141
Pathway	REACTOME_SYNTHESIS_OF_15_EICOSATETRAENOIC_ACID_DERIVATIVES	GPX1 GPX2	8.93e-05	6	35	2	MM14862
Pathway	REACTOME_SYNTHESIS_OF_12_EICOSATETRAENOIC_ACID_DERIVATIVES	GPX1 GPX2	1.25e-04	7	35	2	M27139
Pathway	REACTOME_SYNTHESIS_OF_12_EICOSATETRAENOIC_ACID_DERIVATIVES	GPX1 GPX2	1.25e-04	7	35	2	MM14860
Pathway	WP_15Q25_COPY_NUMBER_VARIATION	DNM3 RYR1 ITPR1	1.98e-04	46	35	3	M48105
Pathway	REACTOME_SYNTHESIS_OF_5_EICOSATETRAENOIC_ACIDS	GPX1 GPX2	2.13e-04	9	35	2	M27136
Pathway	KEGG_MEDICUS_REFERENCE_GLUTATHIONE_BIOSYNTHESIS	GPX1 GPX2	3.25e-04	11	35	2	M47926
Pathway	WP_CELLTYPE_DEPENDENT_SELECTIVITY_OF_CCK2R_SIGNALING	RYR1 ITPR1	4.59e-04	13	35	2	M39589
Pathway	REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING	DNM3 DNM2	5.35e-04	14	35	2	M10122
Pathway	WP_NEPHROGENESIS	ALDH1A2 NOTCH2	8.94e-04	18	35	2	M40045
Pathway	KEGG_MEDICUS_VARIANT_SCRAPIE_CONFORMATION_PRPSC_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY	RYR1 ITPR1	9.97e-04	19	35	2	M47760
Pathway	WP_GLUTATHIONE_METABOLISM	GPX1 GPX2	9.97e-04	19	35	2	M39388
Pubmed	Overlapping Activities of Two Neuronal Splicing Factors Switch the GABA Effect from Excitatory to Inhibitory by Regulating REST.	DNM3 MYO7A OGDH VPS13C ITPR1	6.04e-07	128	44	5	30995482
Pubmed	Analysis of candidate colitis genes in the Gdac1 locus of mice deficient in glutathione peroxidase-1 and -2.	GPX1 GPX2	1.56e-06	2	44	2	22970191
Pubmed	Bacteria-induced intestinal cancer in mice with disrupted Gpx1 and Gpx2 genes.	GPX1 GPX2	1.56e-06	2	44	2	14871826
Pubmed	Low glutathione peroxidase activity in Gpx1 knockout mice protects jejunum crypts from gamma-irradiation damage.	GPX1 GPX2	1.56e-06	2	44	2	10915653
Pubmed	Mutation accumulation in the intestine and colon of mice deficient in two intracellular glutathione peroxidases.	GPX1 GPX2	1.56e-06	2	44	2	17047045
Pubmed	Hair cycle-specific immunolocalization of retinoic acid synthesizing enzymes Aldh1a2 and Aldh1a3 indicate complex regulation.	ALDH1A2 ALDH1A3	1.56e-06	2	44	2	15245423
Pubmed	Microflora trigger colitis in mice deficient in selenium-dependent glutathione peroxidase and induce Gpx2 gene expression.	GPX1 GPX2	1.56e-06	2	44	2	12751789
Pubmed	Long-term potentiation and long-term depression in hippocampal CA1 neurons of mice lacking the IP(3) type 1 receptor.	RYR1 ITPR1	1.56e-06	2	44	2	12654335
Pubmed	Epithelium-specific glutathione peroxidase, Gpx2, is involved in the prevention of intestinal inflammation in selenium-deficient mice.	GPX1 GPX2	1.56e-06	2	44	2	15795427
Pubmed	Colitis locus on chromosome 2 impacting the severity of early-onset disease in mice deficient in GPX1 and GPX2.	GPX1 GPX2	1.56e-06	2	44	2	20872835
Pubmed	Retinoids control anterior and dorsal properties in the developing forebrain.	ALDH1A2 ALDH1A3	1.56e-06	2	44	2	17184764
Pubmed	Expression, characterization, and tissue distribution of a new cellular selenium-dependent glutathione peroxidase, GSHPx-GI.	GPX1 GPX2	1.56e-06	2	44	2	8428933
Pubmed	Distinct and overlapping functions of glutathione peroxidases 1 and 2 in limiting NF-κB-driven inflammation through redox-active mechanisms.	GPX1 GPX2	1.56e-06	2	44	2	31765890
Pubmed	Loss of GPx2 increases apoptosis, mitosis, and GPx1 expression in the intestine of mice.	GPX1 GPX2	1.56e-06	2	44	2	20828612
Pubmed	Raldh3 expression in diabetic islets reciprocally regulates secretion of insulin and glucagon from pancreatic islets.	ALDH1A2 ALDH1A3	1.56e-06	2	44	2	20833146
Pubmed	Differential expression of gastrointestinal glutathione peroxidase (GI-GPx) gene during mouse organogenesis.	GPX1 GPX2	1.56e-06	2	44	2	21323725
Pubmed	Expression and reconstitution of the bioluminescent Ca(2+) reporter aequorin in human embryonic stem cells, and exploration of the presence of functional IP3 and ryanodine receptors during the early stages of their differentiation into cardiomyocytes.	RYR1 ITPR1	1.56e-06	2	44	2	27430888
Pubmed	Inactivation of glutathione peroxidase activity contributes to UV-induced squamous cell carcinoma formation.	GPX1 GPX2	1.56e-06	2	44	2	17510403
Pubmed	The Gdac1 locus modifies spontaneous and Salmonella-induced colitis in mice deficient in either Gpx2 or Gpx1 gene.	GPX1 GPX2	1.56e-06	2	44	2	24090658
Pubmed	Mice with combined disruption of Gpx1 and Gpx2 genes have colitis.	GPX1 GPX2	1.56e-06	2	44	2	11518697
Pubmed	Atherogenic diets exacerbate colitis in mice deficient in glutathione peroxidase.	GPX1 GPX2	1.56e-06	2	44	2	20848490
Pubmed	Rbpj regulates development of prosensory cells in the mammalian inner ear.	MYO7A NOTCH2 PROX1	3.75e-06	24	44	3	21420948
Pubmed	A Y2H-seq approach defines the human protein methyltransferase interactome.	ZNF480 SETMAR AKAP9 ADSS2 ZNF829 KDM4B	4.46e-06	342	44	6	23455924
Pubmed	RALDH3, a retinaldehyde dehydrogenase that generates retinoic acid, is expressed in the ventral retina, otic vesicle and olfactory pit during mouse development.	ALDH1A2 ALDH1A3	4.69e-06	3	44	2	11025231
Pubmed	Dynamin and endocytosis.	DNM3 DNM2	4.69e-06	3	44	2	12383797
Pubmed	The DNA repair component Metnase regulates Chk1 stability.	SETMAR DDB1	4.69e-06	3	44	2	25024738
Pubmed	Consequences of lineage-specific gene loss on functional evolution of surviving paralogs: ALDH1A and retinoic acid signaling in vertebrate genomes.	ALDH1A2 ALDH1A3	4.69e-06	3	44	2	19478994
Pubmed	Retinaldehyde dehydrogenase 2 (RALDH2)- independent patterns of retinoic acid synthesis in the mouse embryo.	ALDH1A2 ALDH1A3	4.69e-06	3	44	2	12454286
Pubmed	Cisplatin-resistant cells in malignant pleural mesothelioma cell lines show ALDH(high)CD44(+) phenotype and sphere-forming capacity.	ALDH1A2 ALDH1A3	4.69e-06	3	44	2	24884875
Pubmed	Structural and kinetic features of aldehyde dehydrogenase 1A (ALDH1A) subfamily members, cancer stem cell markers active in retinoic acid biosynthesis.	ALDH1A2 ALDH1A3	4.69e-06	3	44	2	31923393
Pubmed	Retinoic acid signaling mediates peripheral cone photoreceptor survival in a mouse model of retina degeneration.	ALDH1A2 ALDH1A3	4.69e-06	3	44	2	35315776
Pubmed	Disruption of the coxsackievirus and adenovirus receptor-homodimeric interaction triggers lipid microdomain- and dynamin-dependent endocytosis and lysosomal targeting.	DNM3 DNM2	4.69e-06	3	44	2	24273169
Pubmed	Expression of extracellular glutathione peroxidase in human and mouse gastrointestinal tract.	GPX1 GPX2	4.69e-06	3	44	2	9843785
Pubmed	Side-by-side comparison of recombinant human glutathione peroxidases identifies overlapping substrate specificities for soluble hydroperoxides.	GPX1 GPX2	4.69e-06	3	44	2	36608588
Pubmed	Dynamin: characteristics, mechanism of action and function.	DNM3 DNM2	4.69e-06	3	44	2	12511974
Pubmed	Developmental expression of the dynamin family of mechanoenzymes in the mouse epididymis.	DNM3 DNM2	4.69e-06	3	44	2	28395327
Pubmed	Mining distinct aldehyde dehydrogenase 1 (ALDH1) isoenzymes in gastric cancer.	ALDH1A2 ALDH1A3	4.69e-06	3	44	2	27015121
Pubmed	Differential expression of retinoic acid-synthesizing (RALDH) enzymes during fetal development and organ differentiation in the mouse.	ALDH1A2 ALDH1A3	4.69e-06	3	44	2	11744377
Pubmed	Nox1 causes ileocolitis in mice deficient in glutathione peroxidase-1 and -2.	GPX1 GPX2	4.69e-06	3	44	2	24374371
Pubmed	Type 1 inositol (1,4,5)-trisphosphate receptor activates ryanodine receptor 1 to mediate calcium spark signaling in adult mammalian skeletal muscle.	RYR1 ITPR1	4.69e-06	3	44	2	23223241
Pubmed	Dynamin at the actin-membrane interface.	DNM3 DNM2	4.69e-06	3	44	2	12517701
Pubmed	The Expression of Dynamin 1, 2, and 3 in Human Hepatocellular Carcinoma and Patient Prognosis.	DNM3 DNM2	4.69e-06	3	44	2	32573516
Pubmed	Identification of active retinaldehyde dehydrogenase isoforms in the postnatal human eye.	ALDH1A2 ALDH1A3	4.69e-06	3	44	2	25793304
Pubmed	Concerted action of aldehyde dehydrogenases influences depot-specific fat formation.	ALDH1A2 ALDH1A3	4.69e-06	3	44	2	21436255
Pubmed	Intracellular calcium release channel expression during embryogenesis.	RYR1 ITPR1	4.69e-06	3	44	2	9986730
Pubmed	Dynamin triple knockout cells reveal off target effects of commonly used dynamin inhibitors.	DNM3 DNM2	4.69e-06	3	44	2	24046449
Pubmed	Overlapping role of dynamin isoforms in synaptic vesicle endocytosis.	DNM3 DNM2	9.37e-06	4	44	2	21689597
Pubmed	Dynamic expression of the retinoic acid-synthesizing enzyme retinol dehydrogenase 10 (rdh10) in the developing mouse brain and sensory organs.	ALDH1A2 ALDH1A3	9.37e-06	4	44	2	18399539
Pubmed	Trans-infection but not infection from within endosomal compartments after cell-to-cell HIV-1 transfer to CD4+ T cells.	DNM3 DNM2	9.37e-06	4	44	2	22846998
Pubmed	Astrocytes as a regulated source of retinoic acid for the brain.	ALDH1A2 ALDH1A3	9.37e-06	4	44	2	22930583
Pubmed	Sex-specific timing of meiotic initiation is regulated by Cyp26b1 independent of retinoic acid signalling.	ALDH1A2 ALDH1A3	9.37e-06	4	44	2	21224842
Pubmed	Characterization of cardiac-resident progenitor cells expressing high aldehyde dehydrogenase activity.	ALDH1A2 ALDH1A3	9.37e-06	4	44	2	23484127
Pubmed	Ryanodine receptor calcium release channels: lessons from structure-function studies.	RYR1 ITPR1	9.37e-06	4	44	2	23413940
Pubmed	Expression of Prox1 during mouse cochlear development.	MYO7A PROX1	9.37e-06	4	44	2	16538679
Pubmed	Mutations in OTOGL, encoding the inner ear protein otogelin-like, cause moderate sensorineural hearing loss.	MYO7A OTOGL	9.37e-06	4	44	2	23122586
Pubmed	Two functionally redundant sources of retinoic acid secure spermatogonia differentiation in the seminiferous epithelium.	ALDH1A2 ALDH1A3	9.37e-06	4	44	2	30487180
Pubmed	Partial cloning and differential expression of ryanodine receptor/calcium-release channel genes in human tissues including the hippocampus and cerebellum.	RYR1 ITPR1	9.37e-06	4	44	2	9607712
Pubmed	Sex-specific perinatal expression of glutathione peroxidases during mouse lung development.	GPX1 GPX2	9.37e-06	4	44	2	22326323
Pubmed	Hypoxia differently modulates gene expression of inositol 1,4,5-trisphosphate receptors in mouse kidney and HEK 293 cell line.	RYR1 ITPR1	9.37e-06	4	44	2	19120137
Pubmed	Retinoic acid induces Sertoli cell paracrine signals for spermatogonia differentiation but cell autonomously drives spermatocyte meiosis.	ALDH1A2 ALDH1A3	9.37e-06	4	44	2	23012458
Pubmed	Simultaneous genotyping of 11 non-synonymous SNPs in the 4 glutathione peroxidase genes using the multiplex single base extension method.	GPX1 GPX2	9.37e-06	4	44	2	19161995
Pubmed	Non-cell-autonomous retinoid signaling is crucial for renal development.	ALDH1A2 ALDH1A3	9.37e-06	4	44	2	20040494
Pubmed	Centronuclear myopathies: genotype-phenotype correlation and frequency of defined genetic forms in an Italian cohort.	RYR1 DNM2	9.37e-06	4	44	2	25957634
Pubmed	The Key Transcription Factor Expression in the Developing Vestibular and Auditory Sensory Organs: A Comprehensive Comparison of Spatial and Temporal Patterns.	MYO7A PROX1	9.37e-06	4	44	2	30410537
Pubmed	Novel retinoic acid generating activities in the neural tube and heart identified by conditional rescue of Raldh2 null mutant mice.	ALDH1A2 ALDH1A3	1.56e-05	5	44	2	11959834
Pubmed	Expression patterns of Rbm24 in lens, nasal epithelium, and inner ear during mouse embryonic development.	MYO7A PROX1	1.56e-05	5	44	2	30133047
Pubmed	Growth factor-dependent phosphorylation of the actin-binding protein cortactin is mediated by the cytoplasmic tyrosine kinase FER.	DNM3 DNM2	1.56e-05	5	44	2	9722593
Pubmed	Retinoic acid signaling is directly activated in cardiomyocytes and protects mouse hearts from apoptosis after myocardial infarction.	ALDH1A2 ALDH1A3	1.56e-05	5	44	2	34623260
Pubmed	Intracellular calcium-release channels: regulators of cell life and death.	RYR1 ITPR1	1.56e-05	5	44	2	9124414
Pubmed	Retinoic acid generated by Raldh2 in mesoderm is required for mouse dorsal endodermal pancreas development.	ALDH1A2 PROX1	1.56e-05	5	44	2	15739227
Pubmed	Roles of I(f) and intracellular Ca2+ release in spontaneous activity of ventricular cardiomyocytes during murine embryonic development.	RYR1 ITPR1	2.34e-05	6	44	2	23463619
Pubmed	TAK1 expression in the cochlea: a specific marker for adult supporting cells.	MYO7A PROX1	2.34e-05	6	44	2	21472480
Pubmed	Molecular components required for resting and stimulated endocytosis of botulinum neurotoxins by glutamatergic and peptidergic neurons.	DNM3 DNM2	2.34e-05	6	44	2	23640057
Pubmed	Semaphorin3E-PlexinD1 signaling in coronary artery and lymphatic vessel development with clinical implications in myocardial recovery.	SEMA3E PROX1	2.34e-05	6	44	2	33870127
Pubmed	Targeted disruption of Aldh1a1 (Raldh1) provides evidence for a complex mechanism of retinoic acid synthesis in the developing retina.	ALDH1A2 ALDH1A3	2.34e-05	6	44	2	12808103
Pubmed	Retinoic acid regulates olfactory progenitor cell fate and differentiation.	ALDH1A2 ALDH1A3	2.34e-05	6	44	2	23829703
Pubmed	Dynamin 1- and 3-Mediated Endocytosis Is Essential for the Development of a Large Central Synapse In Vivo.	DNM3 DNM2	2.34e-05	6	44	2	27251629
Pubmed	A clathrin-dynamin-dependent endocytic pathway for the uptake of HIV-1 by direct T cell-T cell transmission.	DNM3 DNM2	2.34e-05	6	44	2	18602423
Pubmed	A calcium-induced calcium release mechanism supports luteinizing hormone-induced testosterone secretion in mouse Leydig cells.	RYR1 ITPR1	2.34e-05	6	44	2	20519450
Pubmed	Variation in the selenoenzyme genes and risk of advanced distal colorectal adenoma.	GPX1 GPX2	2.34e-05	6	44	2	18483336
Pubmed	Essential Roles of Intracellular Calcium Release Channels in Muscle, Brain, Metabolism, and Aging.	RYR1 ITPR1	2.34e-05	6	44	2	25966694
Pubmed	Dynamic expression of retinoic acid-synthesizing and -metabolizing enzymes in the developing mouse inner ear.	ALDH1A2 ALDH1A3	2.34e-05	6	44	2	16615129
Pubmed	A retinoic acid synthesizing enzyme in ventral retina and telencephalon of the embryonic mouse.	ALDH1A2 ALDH1A3	2.34e-05	6	44	2	10906479
Pubmed	IP3Rs are sufficient for dendritic cell Ca2+ signaling in the absence of RyR1.	RYR1 ITPR1	2.34e-05	6	44	2	16844763
Pubmed	DLG1 influences distal ureter maturation via a non-epithelial cell autonomous mechanism involving reduced retinoic acid signaling, Ret expression, and apoptosis.	ALDH1A2 ALDH1A3	2.34e-05	6	44	2	24699546
Pubmed	Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors.	DNM3 ITPR1	2.34e-05	6	44	2	9808459
Pubmed	Amphiphysin (BIN1) negatively regulates dynamin 2 for normal muscle maturation.	RYR1 DNM2	3.27e-05	7	44	2	29130937
Pubmed	Dynamic expression of Lgr5, a Wnt target gene, in the developing and mature mouse cochlea.	MYO7A PROX1	3.27e-05	7	44	2	21472479
Pubmed	Tails of unconventional myosins.	MYO7A MYO7B	3.27e-05	7	44	2	11212352
Pubmed	USP7 and TDP-43: Pleiotropic Regulation of Cryptochrome Protein Stability Paces the Oscillation of the Mammalian Circadian Clock.	USP7 DDB1	3.27e-05	7	44	2	27123980
Pubmed	Proteomic profiling of the human cytomegalovirus UL35 gene products reveals a role for UL35 in the DNA repair response.	USP7 DDB1	3.27e-05	7	44	2	22072767
Pubmed	Positive association between ALDH1A2 and schizophrenia in the Chinese population.	ALDH1A2 ALDH1A3	3.27e-05	7	44	2	19703508
Pubmed	Retinoic acid signaling is dispensable for somatic development and function in the mammalian ovary.	ALDH1A2 ALDH1A3	3.27e-05	7	44	2	28274610
Pubmed	Noncoding Microdeletion in Mouse Hgf Disrupts Neural Crest Migration into the Stria Vascularis, Reduces the Endocochlear Potential, and Suggests the Neuropathology for Human Nonsyndromic Deafness DFNB39.	ALDH1A2 MYO7A	3.27e-05	7	44	2	32152201
Pubmed	Canal cristae growth and fiber extension to the outer hair cells of the mouse ear require Prox1 activity.	MYO7A PROX1	3.27e-05	7	44	2	20186345
Pubmed	HIV-1 viral proteins gp120 and Tat induce oxidative stress in brain endothelial cells.	GPX1 GPX2	3.27e-05	7	44	2	15910762
Pubmed	Developmental expression of the calcium release channels during early neurogenesis of the mouse cerebral cortex.	RYR1 ITPR1	3.27e-05	7	44	2	11860456
Pubmed	Retinaldehyde dehydrogenase enzymes regulate colon enteric nervous system structure and function.	ALDH1A2 ALDH1A3	3.27e-05	7	44	2	23806210
Pubmed	Retinoid metabolism and ALDH1A2 (RALDH2) expression are altered in the transgenic adenocarcinoma mouse prostate model.	ALDH1A2 ALDH1A3	3.27e-05	7	44	2	19549509
Pubmed	Human immunodeficiency virus type 1 Tat protein impairs selenoglutathione peroxidase expression and activity by a mechanism independent of cellular selenium uptake: consequences on cellular resistance to UV-A radiation.	GPX1 GPX2	3.27e-05	7	44	2	11368344
Interaction	MYO7B interactions	USP7 MYO7B	1.40e-05	3	44	2	int:MYO7B
Interaction	ZNF252P-AS1 interactions	N4BP2L2 AKAP9 VPS13C	2.74e-05	27	44	3	int:ZNF252P-AS1
Interaction	NFE2 interactions	USP7 ZNF277 KDM4B CARF	3.36e-05	84	44	4	int:NFE2
Interaction	ZBBX interactions	USP7 DNM3 DNM2	4.18e-05	31	44	3	int:ZBBX
Cytoband	3p26.1	SETMAR ITPR1	5.89e-05	12	44	2	3p26.1
Cytoband	Ensembl 112 genes in cytogenetic band chr3p26	SETMAR ITPR1	1.03e-03	49	44	2	chr3p26
Cytoband	19q13.41	ZNF480 ZNF28	2.57e-03	78	44	2	19q13.41
GeneFamily	A-kinase anchoring proteins\|Myosins, class VII\|Deafness associated genes\|FERM domain containing	MYO7A MYO7B	3.23e-06	2	33	2	1102
GeneFamily	Aldehyde dehydrogenases	ALDH1A2 ALDH1A3	5.42e-04	19	33	2	398
GeneFamily	PHD finger proteins\|Lysine demethylases	KDM6A KDM4B	8.70e-04	24	33	2	485
GeneFamily	Selenoproteins	GPX1 GPX2	9.44e-04	25	33	2	890
GeneFamily	Zinc fingers MYND-type\|A-kinase anchoring proteins	AKAP9 MYO7A	1.27e-03	29	33	2	396
GeneFamily	Ankyrin repeat domain containing\|FERM domain containing	MYO7A MYO7B	3.75e-03	50	33	2	1293
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	AKAP9 RYR1 ITPR1	4.32e-03	181	33	3	694
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF480 ZNF28 ZBTB1 ZNF829 ZNF554	9.19e-03	718	33	5	28
Coexpression	GSE29618_PRE_VS_DAY7_POST_LAIV_FLU_VACCINE_MDC_DN	ZNF480 SETMAR ATP8B4 MYO7A NOTCH2	1.90e-05	196	44	5	M5008
Coexpression	GSE36888_STAT5_AB_KNOCKIN_VS_WT_TCELL_IL2_TREATED_2H_DN	CTSH ZNF277 MICAL2 TRIM3 GPX1	2.00e-05	198	44	5	M8750
Coexpression	GSE32164_RESTING_DIFFERENTIATED_VS_CMYC_INHIBITED_MACROPHAGE_UP	MYO7A CTSH DDHD1 RYR1 GPX1	2.10e-05	200	44	5	M8532
Coexpression	GRYDER_PAX3FOXO1_ENHANCERS_IN_TADS	DNM3 N4BP2L2 SETMAR ATP8B4 ALDH1A3 DDB1 NOTCH2 ITPR1 PROX1	3.77e-05	1009	44	9	M157
ToppCell	Smart-seq2-lymph_node_(Smart-seq2)-lymphocytic-B_lymphocytic-B_cell\|lymph_node_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	MYO7B VPS13C NOTCH2 KDM4B ITPR1	1.34e-06	194	44	5	ff661419b697aef51a53fdeac8d37d870d65f491
ToppCell	10x5'-blood-Lymphocytic_T_CD4-T_CD4/CD8\|blood / Manually curated celltypes from each tissue	N4BP2L2 KDM6A DDHD1 ITPR1	1.97e-05	162	44	4	b4535bcb3f469bc139e73f1122f4070013e5a1de
ToppCell	facs-Marrow-Granulocytes-24m-Lymphocytic-naive_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CTSH RYR1 PROX1 GPX2	2.01e-05	163	44	4	8509b87748ec460992ae6cedbb155e1c6f6e2e48
ToppCell	facs-Marrow-Granulocytes-24m-Lymphocytic-naive_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CTSH RYR1 PROX1 GPX2	2.01e-05	163	44	4	e04de78a52cc886623689a913f7852200a77605b
ToppCell	droplet-Thymus-nan-18m-Myeloid-Macrophage\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FHAD1 ALDH1A2 PROX1 GPX2	2.32e-05	169	44	4	4ac21e8199de4b6917eacadc56fffc6d886ee643
ToppCell	368C-Myeloid-Macrophage-FABP4+_Macrophage_2\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	DNM3 ALDH1A2 SEMA3E PROX1	2.43e-05	171	44	4	e59afa0a773dca3b9c208d17510ea55703b42598
ToppCell	facs-Thymus-Thymus_Flowthrough-18m-Myeloid\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DNM3 CTSH RYR1 NOTCH2	2.60e-05	174	44	4	01eff218e71a04201189a0313aaf91437fffed95
ToppCell	facs-Thymus-Thymus_Flowthrough-18m-Myeloid-macrophage\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DNM3 CTSH RYR1 NOTCH2	2.60e-05	174	44	4	f0f6d135e1fb4c15022be103b00d8d5456515a18
ToppCell	facs-Thymus-Thymus_Flowthrough-18m-Myeloid-macrophage\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DNM3 CTSH RYR1 NOTCH2	2.60e-05	174	44	4	2f4bc0275cbcaa830d04a4c76e042456908d2277
ToppCell	droplet-Limb_Muscle-nan-21m-Macroglial-nan\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ALDH1A2 EFHB CARF SEMA3E	3.10e-05	182	44	4	a512863304fad80acaab60a8c6107eb7c9cbac99
ToppCell	CV-Moderate-7\|Moderate / Virus stimulation, Condition and Cluster	ATP8B4 POLQ VPS13C DDHD1	3.30e-05	185	44	4	a6c9203ce6c2892a4a369c9bcfb85720f01cbb3f
ToppCell	5'-Adult-Distal_Rectal-Epithelial-Tuft-related\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NOTCH2 DNM2 PROX1 GPX2	3.37e-05	186	44	4	4046b701aa29712d9f7c774f8955215122c3c003
ToppCell	CV-Moderate-7\|CV / Virus stimulation, Condition and Cluster	ATP8B4 POLQ VPS13C DDHD1	3.37e-05	186	44	4	8571956890fc9894d766ba294a28e376b4aba428
ToppCell	5'-Adult-Distal_Rectal-Epithelial-Tuft-related-BEST4+_epithelial\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NOTCH2 DNM2 PROX1 GPX2	3.37e-05	186	44	4	bd5837033c1ffcbe5dd30195cc4846a2ba351bcd
ToppCell	Fetal_29-31_weeks-Immune-interstitial_macrophage_(C1Q_positive)-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	NPL ATP8B4 MYO7A RYR1	3.44e-05	187	44	4	39b99f46b723f7f3c44880d7fe8642cbad558b8a
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8\|GI_small-bowel / Manually curated celltypes from each tissue	KDM6A VPS13C DDHD1 ITPR1	3.52e-05	188	44	4	ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCell	PND10-Epithelial\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FHAD1 ALDH1A2 CTSH SEMA3E	3.59e-05	189	44	4	89349e226a5512833a94b1bf68056a6985fe4afd
ToppCell	PND28-Epithelial\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FHAD1 ALDH1A2 CTSH GPX2	3.67e-05	190	44	4	89e5ddd830f70429d5b2fbaf8d0790b033450aa7
ToppCell	Children_(3_yrs)-Immune-interstitial_macrophage_(C1Q_positive)\|Children_(3_yrs) / Lineage, Cell type, age group and donor	NPL ATP8B4 MYO7A RYR1	3.67e-05	190	44	4	f573fef3762a30c38cf8fa7f45df0ffbb49dc873
ToppCell	droplet-Pancreas-Endocrine-21m-Epithelial-pancreatic_D_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ALDH1A3 CTSH SEMA3E ITPR1	3.67e-05	190	44	4	e792e42fc49472eaf974eb0905819eb51a1da8e5
ToppCell	Fetal_29-31_weeks-Immune-interstitial_macrophage_(C1Q_positive)-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	NPL FHAD1 ATP8B4 RYR1	3.74e-05	191	44	4	24d75b7e1d6fb9d24aa7844f584ee888a449841f
ToppCell	CD8+_Memory_T_cell-CV-7\|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster	ATP8B4 POLQ VPS13C DDHD1	3.74e-05	191	44	4	9454f642c3621370fa23640b631301346b300950
ToppCell	PND03-Epithelial\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FHAD1 ALDH1A2 CTSH SEMA3E	3.82e-05	192	44	4	d8c23693f690d4d568585537bbfedda05d505b3d
ToppCell	droplet-Pancreas-Endocrine-21m-Epithelial-pancreatic_D_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ALDH1A3 CTSH SEMA3E ITPR1	3.82e-05	192	44	4	550a6574a93acadb43c449094565c73ca51a0c5c
ToppCell	Epithelial\|World / shred on cell class and cell subclass (v4)	ALDH1A2 AKAP9 CTSH SEMA3E	3.82e-05	192	44	4	13a3553d9a7c78535679d23d454c63fd08f7d218
ToppCell	PCW_05-06-Hematologic_Myeloid-Hem_Myeloid_macrophage-im_immature_macrophage1_(2)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	NPL ATP8B4 MYO7A RYR1	3.90e-05	193	44	4	2684fa361baaa9dc7a18a39ed11c0759e78e4418
ToppCell	Adult-Immune-interstitial_macrophage_(C1Q_positive)\|Adult / Lineage, Cell type, age group and donor	NPL ATP8B4 MYO7A RYR1	3.90e-05	193	44	4	31c0978ba78c9516d498aec0798902e57555e557
ToppCell	Immune-interstitial_macrophage_(C1Q_positive)\|World / Lineage, Cell type, age group and donor	NPL ATP8B4 MYO7A RYR1	3.90e-05	193	44	4	64d598162a256ac6c9f8280c8a9133661dfbb10f
ToppCell	367C-Myeloid-Macrophage-M2-like_Macrophage_(MARCO_negative)\|367C / Donor, Lineage, Cell class and subclass (all cells)	NPL ATP8B4 MYO7A GPX1	3.98e-05	194	44	4	e3688f4252aae5f849f025d7f453ff4c0c14590b
ToppCell	normal_Lung-Myeloid_cells-mo-Mac\|normal_Lung / Location, Cell class and cell subclass	NPL ATP8B4 MYO7A GPX1	4.14e-05	196	44	4	4d3a3264b3d781139899448cde3b7a4f214ca14d
ToppCell	PCW_10-12-Hematologic_Myeloid-Hem_Myeloid_monocytic-im_myeloid_progenitor1_(6)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	NPL ATP8B4 MYO7A RYR1	4.14e-05	196	44	4	ce3709adbde7559b40c964888935914f66003247
ToppCell	Bronchial-NucSeq-Immune_Myeloid-Macrophage_other-Macro_AW_CX3CR1\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ATP8B4 POLQ MYO7A RYR1	4.22e-05	197	44	4	0a404b4494a2246d5a92299235056f0fda4d2b48
ToppCell	Bronchial-NucSeq-Immune_Myeloid-Macrophage_other-Macrophage_intravascular\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	NPL ATP8B4 MYO7A RYR1	4.30e-05	198	44	4	c7dbf24caae5c4ef285845d13055de9e07281bb3
ToppCell	10x5'-lymph-node_spleen-Lymphocytic_B\|lymph-node_spleen / Manually curated celltypes from each tissue	CTSH MYO7B NOTCH2 KDM4B	4.30e-05	198	44	4	1780fa1725a321041094e8c4430673c0a4f3d407
ToppCell	Tracheal-10x5prime-Endothelial-Endothelia_vascular-VE_alveolar_capillary_Car4_aerocyte\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	DNM3 ALDH1A2 MYO7A SEMA3E	4.30e-05	198	44	4	c77421898cc84ae2e8cc335087198dd05f13bfa5
ToppCell	(06)_OLFM4+\|World / shred by cell type by condition	ALDH1A3 AKAP9 NOTCH2 GPX2	4.39e-05	199	44	4	c773b9180dbfec9c19d4098dd43332e6f6050372
ToppCell	kidney_cells-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	N4BP2L2 CD151 AKAP9 VPS13C	4.39e-05	199	44	4	174f6013af6eafa577f84205a62927f2b367fda3
ToppCell	wk_20-22-Hematologic-Myeloid-SPP1+_Mac\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	NPL ATP8B4 MYO7A RYR1	4.39e-05	199	44	4	7c19f1b1f4369edd035ca9cdcf4e653771fc4648
ToppCell	wk_15-18-Hematologic-Myeloid-SPP1+_Mac\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	NPL ATP8B4 MYO7A RYR1	4.39e-05	199	44	4	c7fc2ac1601346aac71e7620a8a440fde8d92dbd
ToppCell	Tracheal-NucSeq-Immune_Myeloid-Macrophage_other-Macrophage_intravascular\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	NPL ATP8B4 MYO7A RYR1	4.39e-05	199	44	4	9545ac59c8d75f5747dff86cb511a149dc103b31
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW23-Mesenchymal\|GW23 / Sample Type, Dataset, Time_group, and Cell type.	NPL ATP8B4 CTSH RYR1	4.48e-05	200	44	4	0eccf41edefc3b8b5d0316f57d5ba572949aec2b
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW23-Mesenchymal-BMP_responsible_cell\|GW23 / Sample Type, Dataset, Time_group, and Cell type.	NPL ATP8B4 CTSH RYR1	4.48e-05	200	44	4	01d707c4f8ee0daac635b7260937b1baebc6fc23
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW16-Mesenchymal-BMP_responsible_cell\|GW16 / Sample Type, Dataset, Time_group, and Cell type.	NPL ATP8B4 CTSH RYR1	4.48e-05	200	44	4	26251ed8c7fa7e87973d6f59bd398c88ad025395
ToppCell	Parenchymal-10x3prime_v2-Immune_Myeloid-Macrophage_other-Macrophage_intravascular\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	NPL ATP8B4 MYO7A CTSH	4.48e-05	200	44	4	4b4df0fe47498310d94448b8a289e58e4f5b5aa8
ToppCell	390C-Lymphocytic-NK_cells-NK_cell_A2\|390C / Donor, Lineage, Cell class and subclass (all cells)	ZNF28 KDM4B CARF	1.80e-04	111	44	3	dfbdeadad321392d359e6fb7112b28b043a4b874
ToppCell	356C-Fibroblasts-Fibroblast-E\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	FHAD1 ZNF480 IFT140	3.27e-04	136	44	3	edfd453c9a650d69d05a5a3ab15f7df56349fa86
ToppCell	356C-Fibroblasts-Fibroblast-E-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	FHAD1 ZNF480 IFT140	3.27e-04	136	44	3	03e4e2353c23ceffde35b2d0aadd15299e3db09f
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L2/3_IT-L2/3_IT_VISp_Rrad\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	NPL ALDH1A3 RYR1	3.41e-04	138	44	3	b3a040c5d0e1cc94d9b19155bca8700edba2d243
ToppCell	droplet-Fat-Scat-21m-Myeloid-monocyte\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ALDH1A2 RYR1 GPX1	4.35e-04	150	44	3	b6e5e04aaf1c5265ac07581868d3159f9292a84c
ToppCell	TCGA-Uterus-Primary_Tumor-Uterine_Carcinoma-Uterine_Carcinosarcoma\|TCGA-Uterus / Sample_Type by Project: Shred V9	ZNF28 AKAP9 CTSH	4.44e-04	151	44	3	2810bfa01bd3016aeba29735eb4a9284792e8aac
ToppCell	droplet-Fat-Scat-21m-Myeloid-nan\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CTSH RYR1 GPX1	4.44e-04	151	44	3	79827a76c675dcb82f59c0a45d0f962b02d5bfd6
ToppCell	343B-Myeloid-Dendritic-cDC1\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	DNM3 IPP ZNF829	4.70e-04	154	44	3	71d33b5dbfab5820e3daddb01806a69116ba8008
ToppCell	E16.5-samps-Epithelial-Alveolar_epithelial_precursor-Noncycling_AT1_Precursor\|E16.5-samps / Age Group, Lineage, Cell class and subclass	ALDH1A2 MICAL2 SEMA3E	4.70e-04	154	44	3	8a643d91896af9b630a715fb284c1523d01ad1a3
ToppCell	PND07-Immune-Immune_Myeloid-DC-cDC2-cDC2_prolif\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ALDH1A2 POLQ RYR1	4.79e-04	155	44	3	b5d5c38b269e9318970fcce564df1c8ed7a7ccc6
ToppCell	droplet-Fat-Scat-21m-Myeloid-myeloid_cell\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CTSH RYR1 GPX1	5.06e-04	158	44	3	718eafcf8a171bb69b402dc9d69564c3521a62a9
ToppCell	Control-Hematopoietic_Meg-Ery-Platelets-Platelets\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	NPL IPP SETMAR	5.06e-04	158	44	3	f2c39b2eff8f2728a9d482d88e0d04984306a3fd
ToppCell	droplet-Fat-Scat-21m-Myeloid\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CTSH RYR1 GPX1	5.06e-04	158	44	3	c8df636412a08c570f235c34d4cff46924a9b11d
ToppCell	Control-Hematopoietic_Meg-Ery-Platelets\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	NPL IPP SETMAR	5.06e-04	158	44	3	fa9797a23254070c569fabe8a314b3e8b3ae9ebd
ToppCell	facs-Marrow-Granulocytes-24m-Lymphocytic\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CTSH PROX1 GPX2	5.16e-04	159	44	3	f0611a7bf15e2f7dfe828dd247650a30b3d6d44d
ToppCell	Severe-B_naive-1\|Severe / disease group and sub_cluster of B and Plasma cells(res = 0.5)	NOTCH2 GPX1 ITPR1	5.16e-04	159	44	3	2881b054bbeb479221ee3c38bbd9b0815b123579
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYO7A RYR1 ITPR1	5.16e-04	159	44	3	00a157d033627d0e65c3fbd38d652c4cf56b47f6
ToppCell	PND07-Epithelial-Epithelial_Airway-Neurosecretory-Secretory\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ALDH1A2 MICAL2 GPX2	5.25e-04	160	44	3	028b5261a1da832d52f66fb620db83e5fbbd874a
ToppCell	PND07-Epithelial-Epithelial_Airway-Neurosecretory-Secretory-Secretory_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ALDH1A2 MICAL2 GPX2	5.25e-04	160	44	3	1f4ee446436726c3d373f56d87dd80b6a12e8b9e
ToppCell	PND03-Epithelial-Epithelial_Airway-Neurosecretory-Secretory\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ALDH1A2 MICAL2 GPX2	5.35e-04	161	44	3	41a89a3d99a9bd6039a3d881d1d9dcd18bc07f25
ToppCell	PND03-Epithelial-Epithelial_Airway-Neurosecretory-Secretory-Secretory_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ALDH1A2 MICAL2 GPX2	5.35e-04	161	44	3	c4970501c038ed36de447da70eabff020ad78713
ToppCell	droplet-Marrow-nan-21m-Hematologic-erythroid_progenitor\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DNM3 TRIM3 RYR1	5.45e-04	162	44	3	d0ffebf5adee8a3ac9b81a4b793184f54010489a
ToppCell	5'-Adult-Appendix-Hematopoietic-T_cells-ILC3\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ATP8B4 EFHB MYO7A	5.54e-04	163	44	3	00e791358a7eb6c3e95f87afe22153845012e4a1
ToppCell	PND10-Epithelial-Epithelial_Airway-Neurosecretory-Secretory-Secretory_prolif\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ALDH1A2 MICAL2 GPX2	5.64e-04	164	44	3	6ea188e17895961cd112152fb111d08641cc5e45
ToppCell	368C-Myeloid-Macrophage-FABP4+_Macrophage_2\|Macrophage / Donor, Lineage, Cell class and subclass (all cells)	DNM3 SEMA3E PROX1	5.74e-04	165	44	3	3d2acdae0dd2b79a15f74158e8e566ce22b4218e
ToppCell	Adult-Immune-interstitial_macrophage_(C1Q_positive)-D122\|Adult / Lineage, Cell type, age group and donor	NPL ATP8B4 MYO7A	5.85e-04	166	44	3	be284e2e596390f05305c7bcfc316f87b963fc0b
ToppCell	facs-Aorta-Heart-3m-Endothelial-endocardial_endothelial_cells\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CTSH OTOGL PROX1	5.95e-04	167	44	3	a4a795751644b22af616335379e64ae95175180c
ToppCell	Smart-seq2-tissue-resident_(Smart-seq2)-myeloid-myeloid_dendritic\|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	ATP8B4 CTSH GPX1	5.95e-04	167	44	3	ecdbfde870a2a44c44b9dd65a8737afc6fbf816c
ToppCell	PND10-Epithelial-Epithelial_Airway-Neurosecretory-Secretory-Secretory_G2M\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ALDH1A2 MICAL2 GPX2	5.95e-04	167	44	3	a90f905ef38437752e2b0b71bd0322a184de1861
ToppCell	frontal_cortex-Non-neuronal-leptomeningeal_cell-VLMC-VLMC_Osr1_Mc5r\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	ALDH1A2 CTSH NOTCH2	6.05e-04	168	44	3	9930bd63b60c03f0152838a79eef77da1c2dd8e5
ToppCell	facs-Lung-EPCAM-3m-Epithelial-club_cell_of_bronchiole\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ALDH1A2 ADSS2 GPX2	6.26e-04	170	44	3	82ccba6ec53f6ca0d19949a1277434c565af2983
ToppCell	droplet-Thymus-nan-21m-Myeloid-professional_antigen_presenting_cell\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DNM3 CTSH RYR1	6.26e-04	170	44	3	29deb285d5a82c0abcc108012ca42f4b4b4d9e19
ToppCell	facs-Brain_Non-Myeloid-Cerebellum_-18m-Mesenchymal-ependymal_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FHAD1 EFHB MYO7A	6.26e-04	170	44	3	b535baeb4dbd644051cf992babb61add9eaae4e3
ToppCell	facs-Brain_Non-Myeloid-Cerebellum_-18m-Mesenchymal-Ependyma\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FHAD1 EFHB MYO7A	6.26e-04	170	44	3	2477c9f29dbe27f172df699003971e828d6ab8c9
ToppCell	facs-Lung-EPCAM-3m-Epithelial-Club_Cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ALDH1A2 ADSS2 GPX2	6.26e-04	170	44	3	ab19ea729ed8c8361c870e79893d1a95a1e487fa
ToppCell	droplet-Thymus-nan-21m-Myeloid\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DNM3 CTSH RYR1	6.26e-04	170	44	3	dc35d66a9a9fe6cdd7f4ec0fe7efa49d02f2b5b2
ToppCell	frontal_cortex-Non-neuronal-leptomeningeal_cell\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	ALDH1A2 CTSH NOTCH2	6.37e-04	171	44	3	2e43fb129ee9bdc3b31febc43c10f959bf0f4a7d
ToppCell	droplet-Lung-nan-18m-Epithelial-Club_Cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FHAD1 ALDH1A2 GPX2	6.37e-04	171	44	3	3b02dc5609f5bcd055b532bb4631d2a7183804e9
ToppCell	E16.5-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Deuterosomal-Deuterosomal_prolif\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FHAD1 ALDH1A2 MICAL2	6.37e-04	171	44	3	4f2a83d8091f1fd29542d2e5add57fd482e921b5
ToppCell	droplet-Thymus-nan-21m-Myeloid-B_cell\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DNM3 CTSH RYR1	6.37e-04	171	44	3	8bed33f61f7d12a1ac4fba33f730d839f5ee7bef
ToppCell	droplet-Lung-nan-18m-Epithelial-club_cell_of_bronchiole\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FHAD1 ALDH1A2 GPX2	6.37e-04	171	44	3	88309bfb1cf427783c853dfd6709cd5edc9074b9
ToppCell	frontal_cortex-Non-neuronal-leptomeningeal_cell-VLMC\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	ALDH1A2 CTSH NOTCH2	6.37e-04	171	44	3	e219a1aa59a96e4bc3e2eacf985679174a51de41
ToppCell	droplet-Marrow-BM-1m-Lymphocytic-immature_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IFT140 NOTCH2 GPX1	6.48e-04	172	44	3	4790323a072cfe76127d704665a42c09601d84be
ToppCell	droplet-Spleen-nan-21m\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DNM3 CTSH RYR1	6.48e-04	172	44	3	3dc02709c2a6be2155576e5c34e1b0b3ae19b061
ToppCell	facs-Trachea-18m-Hematologic-myeloid-tracheal_macrophage-macrophage_of_tracheal_l15\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ATP8B4 CTSH RYR1	6.48e-04	172	44	3	eaba10a4d4eaab42ad2e2da65ebb20b50edaf815
ToppCell	E16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_prolif\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	IFT140 CD151 TRIM3	6.48e-04	172	44	3	8a6a2b4c6654bc976e60a02d0e7303a9071ed55f
ToppCell	E18.5-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ATP8B4 MYO7A GPX1	6.59e-04	173	44	3	279efbab7810fa60ab12ea5d09a84800df4adef0
ToppCell	COPD-Lymphoid-ILC_A\|Lymphoid / Disease state, Lineage and Cell class	ATP8B4 MICAL2 DNM2	6.59e-04	173	44	3	4a0043b29f8ede5a74bdb38cbf2c70e12b25e130
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	NPL ATP8B4 OTOGL	6.59e-04	173	44	3	8888434641ea554a9b62c436e87920378eef29cd
ToppCell	Smart-seq2-lymph_node_(Smart-seq2)-myeloid-myeloid_macrophage-macrophage\|lymph_node_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	NPL GPX1 PROX1	6.70e-04	174	44	3	2479e4804253f55647d2192e40566d713419c51b
ToppCell	(03)_Secretory-(0)_uninjured\|(03)_Secretory / shred by cell type and Timepoint	CTSH TRIM3 NOTCH2	6.70e-04	174	44	3	ebdddb5091afcc49ab533c890f260f709880c5f9
ToppCell	droplet-Lung-18m-Epithelial-airway_epithelial-club_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FHAD1 ALDH1A2 GPX2	6.70e-04	174	44	3	46838b4bb9b4d8ce5e1c608a700e7f393bc52658
ToppCell	droplet-Lung-18m-Epithelial-airway_epithelial-club_cell-club_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FHAD1 ALDH1A2 GPX2	6.70e-04	174	44	3	103594eeb600eb5bc9cbf09a65b286b3a3a18cdc
ToppCell	Smart-seq2-lymph_node_(Smart-seq2)-myeloid-myeloid_macrophage\|lymph_node_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	NPL GPX1 PROX1	6.70e-04	174	44	3	7f1e26b58b66f4ac4c3bc315354bd620ad782eaa
ToppCell	normal_Lung-T/NK_cells-Exhausted_Tfh\|T/NK_cells / Location, Cell class and cell subclass	MYO7A CTSH MICAL2	6.70e-04	174	44	3	e324320b52c904496e26fcecfa179b3431729ec0
ToppCell	5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(nasal)-Club_(nasal)_L.0.2.1.2\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	OTOGL RYR1 GPX2	6.81e-04	175	44	3	9142ed8ca2f1c0c518deb21988221406f62fe38c
Computational	Oxidoreductases.	ALDH1A2 ALDH1A3	5.43e-04	14	27	2	MODULE_464
Computational	Genes in the cancer module 194.	ALDH1A2 ALDH1A3	6.25e-04	15	27	2	MODULE_194
Computational	ROS (glutathione, ox stress).	GPX1 GPX2	7.13e-04	16	27	2	MODULE_530
Drug	Solanine alpha [20562-02-1]; Down 200; 4.6uM; MCF7; HT_HG-U133A	IPP ZNF480 AKAP9 KDM6A NOTCH2	3.62e-05	195	44	5	2808_DN
Drug	Nizatidine [76963-41-2]; Down 200; 12uM; HL60; HT_HG-U133A	ZNF480 IFT140 MYO7A ZBTB1 PROX1	3.62e-05	195	44	5	3047_DN
Drug	linoleic acid hydroperoxide	GPX1 GPX2	3.64e-05	5	44	2	ctd:C008285
Drug	Telenzepine dihydrochloride [147416-96-4]; Down 200; 9uM; HL60; HT_HG-U133A	AKAP9 KDM6A ZNF277 KDM4B DNM2	3.71e-05	196	44	5	2388_DN
Drug	Liothyronine [6893-02-3]; Down 200; 6.2uM; MCF7; HT_HG-U133A	ZBTB1 KDM6A ZNF277 TRIM3 DNM2	3.71e-05	196	44	5	3324_DN
Drug	Propoxycaine hydrochloride [550-83-4]; Up 200; 12uM; PC3; HT_HG-U133A	IFT140 ZBTB1 ZNF277 TRIM3 KDM4B	3.71e-05	196	44	5	7155_UP
Drug	Eucatropine hydrochloride [536-93-6]; Up 200; 12.2uM; MCF7; HT_HG-U133A	USP7 AKAP9 ZNF277 MICAL2 CARF	3.71e-05	196	44	5	3416_UP
Drug	Lisinopril [83915-83-7]; Down 200; 9uM; MCF7; HT_HG-U133A	NPL ZNF480 AKAP9 MICAL2 NOTCH2	3.71e-05	196	44	5	5504_DN
Drug	0316684-0000 [391209-55-5]; Up 200; 10uM; MCF7; HT_HG-U133A	AKAP9 MICAL2 TRIM3 NOTCH2 KDM4B	3.81e-05	197	44	5	7093_UP
Drug	chlorpromazine hydrochloride; Up 200; 1uM; MCF7; HT_HG-U133A	NPL USP7 IFT140 MICAL2 KDM4B	3.81e-05	197	44	5	6936_UP
Drug	Minocycline hydrochloride [13614-98-7]; Up 200; 8uM; MCF7; HT_HG-U133A	USP7 IPP KDM6A TRIM3 RYR1	4.09e-05	200	44	5	7436_UP
Drug	AC1Q7BER	RYR1 ITPR1	5.45e-05	6	44	2	CID000005702
Drug	Br2BAPTA	RYR1 ITPR1	7.62e-05	7	44	2	CID003081001
Drug	[[(2R,3S,4R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4R,5R)-3,4,5-trihydroxyoxolan-2-yl]methyl hydrogen phosphate	RYR1 ITPR1	7.62e-05	7	44	2	CID009547999
Drug	2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine	N4BP2L2 AKAP9 KDM6A ZNF277 KDM4B CARF ITPR1	7.79e-05	546	44	7	ctd:C532162
Disease	Charcot-Marie-Tooth disease dominant intermediate B (implicated_via_orthology)	DNM3 DNM2	2.17e-05	5	44	2	DOID:0110197 (implicated_via_orthology)
Disease	centronuclear myopathy 1 (implicated_via_orthology)	DNM3 DNM2	2.17e-05	5	44	2	DOID:0111223 (implicated_via_orthology)
Disease	microcytic anemia (implicated_via_orthology)	DNM3 DNM2	2.17e-05	5	44	2	DOID:11252 (implicated_via_orthology)
Disease	level of Phosphatidylcholine (16:0_22:6) in blood serum	ALDH1A2 ZNF277	4.54e-05	7	44	2	OBA_2045080
Disease	Bladder Neoplasm	USP7 KDM6A NOTCH2 GPX1	5.69e-05	140	44	4	C0005695
Disease	Malignant neoplasm of urinary bladder	USP7 KDM6A NOTCH2 GPX1	5.85e-05	141	44	4	C0005684
Disease	IGF-1 measurement	IFT140 OGDH VPS13C KDM4B DNM2 PROX1	8.22e-05	488	44	6	EFO_0004627
Disease	collagen disease (implicated_via_orthology)	DNM3 DNM2	1.42e-04	12	44	2	DOID:854 (implicated_via_orthology)
Disease	Autosomal Dominant Myotubular Myopathy	RYR1 DNM2	1.68e-04	13	44	2	C3661489
Disease	Centronuclear myopathy	RYR1 DNM2	1.68e-04	13	44	2	C0175709
Disease	X-linked centronuclear myopathy	RYR1 DNM2	1.68e-04	13	44	2	C0410203
Disease	developmental and epileptic encephalopathy (implicated_via_orthology)	DNM3 DNM2	1.68e-04	13	44	2	DOID:0112202 (implicated_via_orthology)
Disease	Congenital Structural Myopathy	RYR1 DNM2	1.68e-04	13	44	2	C0752282
Disease	Myopathy, Centronuclear, 1	RYR1 DNM2	1.68e-04	13	44	2	C4551952
Disease	stomach cancer (is_implicated_in)	KDM6A KDM4B GPX1	1.72e-04	72	44	3	DOID:10534 (is_implicated_in)
Disease	Myopathy, Centronuclear, Autosomal Dominant	RYR1 DNM2	1.96e-04	14	44	2	C1834558
Disease	Tubular Aggregate Myopathy	RYR1 DNM2	1.96e-04	14	44	2	C0410207
Disease	Autosomal Recessive Centronuclear Myopathy	RYR1 DNM2	2.25e-04	15	44	2	C3645536
Disease	Neoplasm of uncertain or unknown behavior of bladder	KDM6A NOTCH2	2.25e-04	15	44	2	C0496930
Disease	N-acetylmethionine measurement	MICAL2 ITPR1	2.25e-04	15	44	2	EFO_0021427
Disease	Benign neoplasm of bladder	KDM6A NOTCH2	2.25e-04	15	44	2	C0154017
Disease	Carcinoma in situ of bladder	KDM6A NOTCH2	2.25e-04	15	44	2	C0154091
Disease	obesity (implicated_via_orthology)	ALDH1A2 NOTCH2 ITPR1 PROX1	2.96e-04	215	44	4	DOID:9970 (implicated_via_orthology)
Disease	sphingosine 1-phosphate measurement	KDM6A ITPR1	3.27e-04	18	44	2	EFO_0800185
Disease	Carcinoma of bladder	KDM6A NOTCH2	3.27e-04	18	44	2	C0699885
Disease	Congenital Fiber Type Disproportion	RYR1 DNM2	3.27e-04	18	44	2	C0546264
Disease	brain cancer (implicated_via_orthology)	NOTCH2 PROX1	6.90e-04	26	44	2	DOID:1319 (implicated_via_orthology)
Disease	colorectal cancer (is_implicated_in)	KDM6A KDM4B GPX1	7.88e-04	121	44	3	DOID:9256 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
QAHAVCQQEQHYFNE	AKAP9	1476	Q99996
EQAHQGVFFNQGQCC	ALDH1A2	306	O94788
FPCNQFGHQENAKNE	GPX1	76	P07203
VQFDNCNFENGHIQV	FBXO10	201	Q9UK96
DLAVECAHQGVFFNQ	ALDH1A3	296	P47895
FGQNRNFSNGHVVCE	ATP8B4	721	Q8TF62
RNGQHFCDVQLQVGQ	IPP	31	Q9Y573
QAGFDGVHCENNINE	NOTCH2	976	Q04721
LAHEFLQNFCAGNQQ	ITPR1	1246	Q14643
HQENNNFCSVNINIG	KDM6A	1146	O15550
EQFHLVDQNGQAIQY	CARF	76	Q8N187
INTNHEDFIGFANAQ	DNM3	486	Q9UQ16
NQEHVSCQQAFEHFA	KDM4B	541	O94953
INTNHEDFIGFANAQ	DNM2	486	P50570
QFGDFHNTAQCIIDQ	OGDH	746	Q02218
FNSRNGTFVNECHIQ	FHAD1	56	B1AJZ9
TSSFNCNFQNGNQEH	POLQ	966	O75417
CNFQNGNQEHQTCSI	POLQ	971	O75417
EQQLVDCAQDFNNHG	CTSH	166	P09668
CQFAQQHEQRKEAGN	EFHB	221	Q8N7U6
EHLNCFRGQQMQENF	DDHD1	311	Q8NEL9
VDQLQQEFHCCGSNN	CD151	146	P48509
FPCNQFGHQENCQNE	GPX2	66	P18283
FGHQENCQNEEILNS	GPX2	71	P18283
FLQLLCEGHNNDFQN	RYR1	3886	P21817
HCFQGNVQKAAQIAN	IFT140	991	Q96RY7
QTFFCGNVAHQQLIQ	DDB1	456	Q16531
CQQQTEGYQHVNVTD	MICAL2	526	O94851
NINQQNIGYAAHCDV	OTOGL	666	Q3ZCN5
DFGQCVDQNRQQQFA	NPL	181	Q9BXD5
NFHTANQRLQCFGDV	PROX1	401	Q92786
GKRFHNQQDAENAFQ	SETMAR	636	Q53H47
VFDFHQAADGIQEQQ	ADSS2	136	P30520
NNDINQESGVAFHND	VPS13C	1951	Q709C8
CGKTFNQNSQFIQHQ	ZNF829	161	Q3KNS6
VCFQIFPNNEQLEQH	ZBTB1	666	Q9Y2K1
RVINGCNQVENFINH	ZNF480	146	Q8WV37
QQQQERNDTNFHGVC	ZNF277	161	Q9NRM2
NECGKVFNQQAHLAQ	ZNF28	666	P17035
QDVRHGNAAQQCFGQ	SEMA3E	561	O15041
QVQIVAEDQFCGHQG	USP7	566	Q93009
NNQCIQVFSNEGQFK	TRIM3	506	O75382
NECGNAIRQNSHFIQ	ZNF554	276	Q86TJ5
HNGTDRFVNQQFQEE	N4BP2L2	381	Q92802
QLCINFANEHLQQFF	MYO7A	451	Q13402
NNSFEQLCINFANEH	MYO7B	446	Q6PIF6
QLCINFANEHLQQFF	MYO7B	451	Q6PIF6